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1995:
Yazaki T; Takamiya Y; Costello P C; Mineta T; Menon A G; Rabkin S D; Martuza R L
Inhibition of angiogenesis and growth of human non-malignant and malignant meningiomas by TNP-470.
Journal of neuro-oncology 1995;
23(
1):.
Meningiomas are relatively common (22%) vascular brain tumors. 3-11% of meningiomas are malignant, and defy currently available therapy. Inhibition of neovascularization is one potential strategy for treating these hypervascular tumors. Inhibition of tumor-induced angiogenesis by TNP-470 (previously termed AGM-1470), a synthetic analogue of fumagillin, was tested on the growth of human non-malignant and malignant meningiomas in nude mice. TNP-470 significantly inhibited tumor neovascularization and tumor growth of both non-malignant and malignant meningiomas. TNP-470 is now in human trial and should be tested for efficacy in treating malignant or recurrent aggressive meningiomas.
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