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1995:
Cigudosa J C; Pedrosa Guerra A; Otero Gómez A; Carrasco Juan J L; Pérez Gómez J A; Ferrer Roca O F; García Miranda J L
Translocation (5;19)(q13;q13) in a multinodular thyroid goiter.
Cancer genetics and cytogenetics 1995;
82(
1):.
We describe the cytogenetics of a multinodular thyroid goiter where 90% of the analyzed cells showed a diploid karyotype with a balanced translocation between chromosomes 5 and 19: 46,XX,t(5;19)(q13;q13). This translocation has been previously described in cases of thyroid adenoma. Our case is the first report of this anomaly in nodular hyperplasia. We discuss its putative role in the neoplastic transformation of thyroid lesions.
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