Preview
Sign-in for full Details 
Sign-in free and Explore the Exciting World of BiomedExperts:
- Over 1.500.000 Profiles
- More than 1.800 Organizations worldwide
- State of the Art Network Visualizations
- Manage your own Profile
- Locate Experts in your Country/Region
- Locate Experts in your 1. and 2. Level Network
- Connect to Experts Worldwide
find experts for
Sign-in to see more
1998:
Nichterlein T; Bornitz F; Kretschmar M; Hof H
Successful treatment of murine listeriosis and salmonellosis with levofloxacin.
Journal of chemotherapy (Florence, Italy) 1998;
10(
4):.
Levofloxacin (L-ofloxacin) is a fluoroquinolone derivative. It is the active substance contained in ofloxacin with a broad spectrum of antibacterial activity against both Gram-negative and Gram-positive bacteria. In this work we examined the activity of levofloxacin against the facultative intracellular bacteria Listeria monocytogenes and Salmonella typhimurium in vitro, in tissue culture and in animal models of infection. The minimum inhibitory concentrations (MICs) MIC90 for Salmonella enterica and L. monocytogenes were 0.078 mg/l and 4 mg/l, respectively. Levofloxacin was bactericidal against L. monocytogenes and S. typhimurium because 8 x MIC killed 90% of the initial inoculum of L. monocytogenes EGD and S. typhimurium LT2 within 4 hours and 3 hours, respectively. Levofloxacin was more effective than ampicillin against L. monocytogenes EGD infecting tissue culture cells. Also in tissue culture cells infected with S. typhimurium LT2, levofloxacin was slightly more effective than ciprofloxacin. In animal models of infection, levofloxacin was as potent as the reference substances. In conclusion, levofloxacin is a candidate for the treatment of infections caused by facultative intracellular Gram-positive and Gram-negative bacteria.
Post to CiteULike 
Sign in free and see...
Visualized networks:
See your personal network in
sophisticated graphical views
GeoTargeted Searches:
Locate experts around the world
and connect with global collaborators
Research Profiles:
See the visualized research activity
of experts around the globe
Sign-in to see more
