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Experts in Histocompatibility Antigens Class I
Large transmembrane, polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin. In humans, three structural genes on chromosome 6 code for the HLA-A; HLA-B and HLA-C antigens. In mice, three genes named K, D, and L on chromosome 17 code for the H-2 antigens. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during graft rejection and restrict cell-mediated lysis of virus-infected cells. They are primarily associated with rheumatologic diseases and certain malignant disorders.
- Carosella, Edgardo
- Ploegh, Hidde
- Rouas-Freiss, Nathalie
- Dausset, Jean
- Watkins, David
- yewdell, jon
- Ferrone, Soldano
- Inoko, Hidetoshi
- Parham, Peter
- Garrido, Federico
- Spies, Thomas
- Moretta, Lorenzo
- Moretta, Alessandro
- Neefjes, Jacques
- Moreau, Philippe
- Cresswell, Peter
- Le Bouteiller, Philippe
- Lanier, Lewis
- Rammensee, Hans-Georg
- Weiss, Elisabeth
- Barton, James
- Kärre, Klas
- Hansen, Ted
- Bennink, Jack
- Letvin, Norman
- Storb, Rainer
- Beutler, Ernest
- Claas, Frans
- Melief, Cornelis
- Ruiz-Cabello, Francisco