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Experts in Buthionine Sulfoximine
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
- Biaglow, John
- Cederbaum, Arthur
- Friedman, Henry
- Mitchell, James
- Jones, Dean
- Bigner, Darell
- Chatterjee, Anupam
- Colvin, Michael
- O'Dwyer, Peter
- Spitz, Douglas
- Estrela, José
- Hamilton, Thomas
- Kang, James
- Ozols, Robert
- Russo, Angelo
- Akaike, Akinori
- Anderson, Mary
- Batist, Gerald
- Chang, Yu-Chao
- Clark, John
- Freeman, Michael
- Ghibelli, Lina
- Meredith, Michael
- Reynolds, Patrick
- Anderson, Clarke
- Castagné, Vincent
- Elion, GB
- Haddad, John
- Harris, Craig
- Heales, Simon
