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Experts in Dactinomycin
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
- Newlands, Edward
- D'Angio, Giulio
- Bosl, George
- Green, Daniel
- Rustin, Gordon
- Breslow, Norman
- Jürgens, Heribert
- Baltimore, David
- Chen, Fu-Ming
- Gelehrter, Thomas
- Holden, Lydia
- O'Malley, Bert
- Bagshawe, Kenneth
- Grier, Holcombe
- Cotter, Thomas
- Donaldson, Sarah
- Dunst, Jürgen
- Lurain, John
- Pastan, Ira
- Bacci, Gaetano
- Begent, Richard
- Billiar, Timothy
- Crist, William
- Ferrari, Stefano
- Finklestein, Jerry
- Gehan, Edmund
- Herr, Harry
- Maurer, Harold
- Nick, Harry
- Patel, Dinshaw
