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Kazuwa Nakao

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Iwanishi Masanori; Ebihara Ken; Kusakabe Toru; Chen Wen; Ito Jun; Masuzaki Hiroaki; Hosoda Kiminori; Nakao Kazuwa
Clinical characteristics and efficacy of pioglitazone in a Japanese diabetic patient with an unusual type of familial partial lipodystrophy.
Sawada Naoki; Itoh Hiroshi; Miyashita Kazutoshi; Tsujimoto Hirokazu; Sone Masakatsu; Yamahara Kenichi; Arany Zoltan P; Hofmann Franz; Nakao Kazuwa
Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels.
Nakao Kazuwa; Yasoda Akihiro; Ebihara Ken; Hosoda Kiminori; Mukoyama Masashi
Translational research of novel hormones: lessons from animal models and rare human diseases for common human diseases.

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All Publications

2009: Iwanishi Masanori; Ebihara Ken; Kusakabe Toru; Chen Wen; Ito Jun; Masuzaki Hiroaki; Hosoda Kiminori; Nakao Kazuwa
Clinical characteristics and efficacy of pioglitazone in a Japanese diabetic patient with an unusual type of familial partial lipodystrophy.
Metabolism: clinical and experimental 2009;58(12):1681-7.
2009: Sawada Naoki; Itoh Hiroshi; Miyashita Kazutoshi; Tsujimoto Hirokazu; Sone Masakatsu; Yamahara Kenichi; Arany Zoltan P; Hofmann Franz; Nakao Kazuwa
Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels.
Molecular and cellular biology 2009;29(22):6018-32.
2009: Nakao Kazuwa; Yasoda Akihiro; Ebihara Ken; Hosoda Kiminori; Mukoyama Masashi
Translational research of novel hormones: lessons from animal models and rare human diseases for common human diseases.
Journal of molecular medicine (Berlin, Germany) 2009;87(10):1029-39.
2009: Nakagawa Yasuaki; Kuwahara Koichiro; Takemura Genzo; Akao Masaharu; Kato Masashi; Arai Yuji; Takano Makoto; Harada Masaki; Murakami Masao; Nakanishi Michio; Usami Satoru; Yasuno Shinji; Kinoshita Hideyuki; Fujiwara Masataka; Ueshima Kenji; Nakao Kazuwa
p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.
Circulation research 2009;105(8):746-54.
2009: Nakao Kazuwa
Strategy for translational research and breakthroughs for common human diseases using excellent animal models and rare human diseases.
Endocrine journal 2009;56(5):637-8.
2009: Tokudome Takeshi; Kishimoto Ichiro; Yamahara Kenichi; Osaki Tsukasa; Minamino Naoto; Horio Takeshi; Sawai Kazutomo; Kawano Yuhei; Miyazato Mikiya; Sata Masataka; Kohno Masakazu; Nakao Kazuwa; Kangawa Kenji
Impaired recovery of blood flow after hind-limb ischemia in mice lacking guanylyl cyclase-A, a receptor for atrial and brain natriuretic peptides.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(10):1516-21.
2009: Kinoshita Hideyuki; Kuwahara Koichiro; Takano Makoto; Arai Yuji; Kuwabara Yoshihiro; Yasuno Shinji; Nakagawa Yasuaki; Nakanishi Michio; Harada Masaki; Fujiwara Masataka; Murakami Masao; Ueshima Kenji; Nakao Kazuwa
T-type Ca2+ channel blockade prevents sudden death in mice with heart failure.
Circulation 2009;120(9):743-52.
2009: Iwakura Hiroshi; Ariyasu Hiroyuki; Li Yushu; Kanamoto Naotetsu; Bando Mika; Yamada Go; Hosoda Hiroshi; Hosoda Kiminori; Shimatsu Akira; Nakao Kazuwa; Kangawa Kenji; Akamizu Takashi
A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance.
American journal of physiology. Endocrinology and metabolism 2009;297(3):E802-11.
2009: Miyamoto Yoshihiro; Morisaki Hiroko; Yamanaka Itaru; Kokubo Yoshihiro; Masuzaki Hiroaki; Okayama Akira; Tomoike Hitonobu; Nakao Kazuwa; Okamura Tomonori; Yoshimasa Yasunao; Morisaki Takayuki
Association study of 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort.
Diabetes research and clinical practice 2009;85(2):132-8.
2009: Kasahara Masato; Mori Kiyoshi; Satoh Noriko; Kuwabara Takashige; Yokoi Hideki; Shimatsu Akira; Sugawara Akira; Mukoyama Masashi; Nakao Kazuwa
Reduction in urinary excretion of neutrophil gelatinase-associated lipocalin by angiotensin receptor blockers in hypertensive patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(8):2608-9; author reply 2609-10.
2009: Yasuno Shinji; Ueshima Kenji; Oba Koji; Fujimoto Akira; Ogihara Toshio; Saruta Takao; Nakao Kazuwa
Clinical significance of left ventricular hypertrophy and changes in left ventricular mass in high-risk hypertensive patients: a subanalysis of the Candesartan Antihypertensive Survival Evaluation in Japan trial.
Journal of hypertension 2009;27(8):1705-12.
2009: Li Yuhao; Saito Yoshihiko; Kuwahara Koichiro; Rong Xianglu; Kishimoto Ichiro; Harada Masaki; Adachi Yuichiro; Nakanishi Michio; Kinoshita Hideyuki; Horiuchi Masatsugu; Murray Michael; Nakao Kazuwa
Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart.
Endocrinology 2009;150(8):3759-65.
2009: Mori Kiyoshi; Mukoyama Masashi; Nakao Kazuwa
[Novel biological involvement of siderophore-binding proteins-from hematopoiesis to cell differentiation, tissue injury, carcinogenesis and infection]
[Rinsho ketsueki] The Japanese journal of clinical hematology 2009;50(7):519-26.
2009: Yasoda Akihiro; Nakao Kazuwa
[Hormones and osteoporosis update. Effects of natriuretic peptides on endochondral bone growth]
Clinical calcium 2009;19(7):1003-8.
2009: Taura Daisuke; Sone Masakatsu; Homma Koichiro; Oyamada Naofumi; Takahashi Kazutoshi; Tamura Naohisa; Yamanaka Shinya; Nakao Kazuwa
Induction and isolation of vascular cells from human induced pluripotent stem cells--brief report.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(7):1100-3.
2009: Masuzaki Hiroaki; Tanaka Tomohiro; Ebihara Ken; Hosoda Kiminori; Nakao Kazuwa
Hypothalamic melanocortin signaling and leptin resistance--perspective of therapeutic application for obesity-diabetes syndrome.
Peptides 2009;30(7):1383-6.
2009: Yasoda Akihiro; Kitamura Hidetomo; Fujii Toshihito; Kondo Eri; Murao Naoaki; Miura Masako; Kanamoto Naotetsu; Komatsu Yasato; Arai Hiroshi; Nakao Kazuwa
Systemic administration of C-type natriuretic peptide as a novel therapeutic strategy for skeletal dysplasias.
Endocrinology 2009;150(7):3138-44.
2009: Mori Kiyoshi; Mukoyama Masashi; Kuwabara Takashige; Kasahara Masato; Yokoi Hideki; Nakao Kazuwa
[Clinical implication of a novel biomarker Ngal in CKD]
Nippon rinsho. Japanese journal of clinical medicine 2009;67(6):1233-41.
2009: Sonoyama Takuhiro; Tamura Naohisa; Miyashita Kazutoshi; Park Kwijun; Oyamada Naofumi; Taura Daisuke; Inuzuka Megumi; Fukunaga Yasutomo; Sone Masakatsu; Nakao Kazuwa
Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide.
FEBS letters 2009;583(12):2067-70.
2009: Saruta Takao; Hayashi Koichi; Ogihara Toshio; Nakao Kazuwa; Fukui Tsuguya; Fukiyama Kohshiro;
Effects of candesartan and amlodipine on cardiovascular events in hypertensive patients with chronic kidney disease: subanalysis of the CASE-J Study.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(6):505-12.
2009: Yasuno Shinji; Usami Satoru; Kuwahara Koichiro; Nakanishi Michio; Arai Yuji; Kinoshita Hideyuki; Nakagawa Yasuaki; Fujiwara Masataka; Murakami Masao; Ueshima Kenji; Harada Masaki; Nakao Kazuwa
Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death.
American journal of physiology. Heart and circulatory physiology 2009;296(6):H1804-10.
2009: Ueshima Kenji; Yasuno Shinji; Oba Koji; Fujimoto Akira; Ogihara Toshio; Saruta Takao; Nakao Kazuwa
Effects of cardiac complications on cardiovascular events in Japanese high-risk hypertensive patients: subanalysis of the CASE-J trial.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(6):1080-5.
2009: Ogihara Toshio; Saruta Takao; Rakugi Hiromi; Fujimoto Akira; Ueshima Kenji; Yasuno Shinji; Oba Koji; Takeda Kazuo; Higaki Jitsuo; Nakao Kazuwa;
Relationship between the achieved blood pressure and the incidence of cardiovascular events in Japanese hypertensive patients with complications: a sub-analysis of the CASE-J trial.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(4):248-54.
2009: Hotta Kikuko; Nakamura Takahiro; Takasaki Junichi; Takahashi Hiroshi; Takahashi Atsushi; Nakata Yoshio; Kamohara Seika; Kotani Kazuaki; Komatsu Ryoya; Itoh Naoto; Mineo Ikuo; Wada Jun; Masuzaki Hiroaki; Yoneda Masato; Nakajima Atsushi; Funahashi Tohru; Miyazaki Shigeru; Tokunaga Katsuto; Hamaguchi Kazuyuki; Tanaka Kiyoji; Yamada Kentaro; Hanafusa Toshiaki; Oikawa Shinichi; Yoshimatsu Hironobu; Nakao Kazuwa; Sakata Toshiie; Matsuzawa Yuji; Kamatani Naoyuki; Nakamura Yusuke
Screening of 336 single-nucleotide polymorphisms in 85 obesity-related genes revealed McKusick-Kaufman syndrome gene variants are associated with metabolic syndrome.
Journal of human genetics 2009;54(4):230-5.
2009: Kusakabe T; Tanioka H; Ebihara K; Hirata M; Miyamoto L; Miyanaga F; Hige H; Aotani D; Fujisawa T; Masuzaki H; Hosoda K; Nakao K
Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet.
Diabetologia 2009;52(4):675-83.
2009: Taura Daisuke; Noguchi Michio; Sone Masakatsu; Hosoda Kiminori; Mori Eisaku; Okada Yohei; Takahashi Kazutoshi; Homma Koichiro; Oyamada Naofumi; Inuzuka Megumi; Sonoyama Takuhiro; Ebihara Ken; Tamura Naohisa; Itoh Hiroshi; Suemori Hirofumi; Nakatsuji Norio; Okano Hideyuki; Yamanaka Shinya; Nakao Kazuwa
Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells.
FEBS letters 2009;583(6):1029-33.
2009: Hirata Masakazu; Oba Kouji; Ueshima Kenji; Nakao Kazuwa
[Obesity in CASE-J Study]
Nippon rinsho. Japanese journal of clinical medicine 2009;67(2):404-7.
2009: Masuzaki Hiroaki; Tanaka Tomohiro; Ebihara Ken; Hosoda Kiminori; Nakao Kazuwa
[Energy homeostasis regulated by an adipocyte-derived hormone--mechanism of leptin resistance and role of hypothalamic melanocortin signaling]
Nippon rinsho. Japanese journal of clinical medicine 2009;67(2):287-96.
2009: Hosoda Kiminori; Ida Midori; Hirata Masakazu; Nakao Kazuwa
[Concept and classification of obesity]
Nippon rinsho. Japanese journal of clinical medicine 2009;67(2):229-35.
2009: Nakao Kazuwa
Adiposcience and adipotoxicity.
Nature clinical practice. Endocrinology & metabolism 2009;5(2):63.
2009: Kuwabara Takashige; Mori Kiyoshi; Mukoyama Masashi; Kasahara Masato; Yokoi Hideki; Saito Yoko; Yoshioka Tetsuro; Ogawa Yoshihisa; Imamaki Hirotaka; Kusakabe Toru; Ebihara Ken; Omata Mitsugu; Satoh Noriko; Sugawara Akira; Barasch Jonathan; Nakao Kazuwa
Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons.
Kidney international 2009;75(3):285-94.
2009: Ma Xiao; Iwanaka Nobumasa; Masuda Shinya; Karaike Kouhei; Egawa Tatsuro; Hamada Taku; Toyoda Taro; Miyamoto Licht; Nakao Kazuwa; Hayashi Tatsuya
Morus alba leaf extract stimulates 5'-AMP-activated protein kinase in isolated rat skeletal muscle.
Journal of ethnopharmacology 2009;122(1):54-9.
2009: Sone Masakatsu; Shibata Hirotaka; Homma Keiko; Tamura Naohisa; Akahira Jun-Ichi; Hamada Satoshi; Yahata Mitsuhiko; Fukui Nobuyuki; Itoh Hiroshi; Sasano Hironobu; Nakao Kazuwa
Close examination of steroidogenesis disorders in a DOC- and progesterone-producing adrenocortical carcinoma.
Endocrine 2009;35(1):25-33.
2009: Yamada Nobuko; Katsuura Goro; Tatsuno Ichiro; Kawahara Shigenori; Ebihara Ken; Saito Yasushi; Nakao Kazuwa
Orexins increase mRNA expressions of neurotrophin-3 in rat primary cortical neuron cultures.
Neuroscience letters 2009;450(2):132-5.
2009: Ueshima Kenji; Oba Koji; Yasuno Shinji; Fujimoto Akira; Sato Tosiya; Fukiyama Koshiro; Azuma Junichi; Ogihara Toshio; Saruta Takao; Nakao Kazuwa;
Long-term effects of candesartan and amlodipine on cardiovascular mortality and morbidity in Japanese high-risk hypertensive patients: rationale, design, and characteristics of candesartan antihypertensive survival evaluation in Japan extension (CASE-J Ex).
Contemporary clinical trials 2009;30(1):97-101.
2009: Majima Takafumi; Shimatsu Akira; Komatsu Yasato; Satoh Noriko; Fukao Atsushi; Ninomiya Kiyoshi; Matsumura Tadashi; Nakao Kazuwa
Effects of risedronate or alfacalcidol on bone mineral density, bone turnover, back pain, and fractures in Japanese men with primary osteoporosis: results of a two-year strict observational study.
Journal of bone and mineral metabolism 2009;27(2):168-74.
2008: Fukui Nobuyuki; Mukoyama Masashi; Saito Yoko; Mori Kiyoshi; Kasahara Masato; Yokoi Hideki; Ogawa Yoshihisa; Kuwabara Takashige; Sugawara Akira; Nakao Kazuwa
[Systemic AA amyloidosis caused by familial Mediterranean fever and response to colchicine]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2008;97(12):3046-8.
2008: Iwakura Hiroshi; Ariyasu Hiroyuki; Kanamoto Naotetsu; Hosoda Kiminori; Nakao Kazuwa; Kangawa Kenji; Akamizu Takashi
Establishment of a novel neuroblastoma mouse model.
International journal of oncology 2008;33(6):1195-9.
2008: Tsuji Takehito; Kondo Eri; Yasoda Akihiro; Inamoto Masataka; Kiyosu Chiyo; Nakao Kazuwa; Kunieda Tetsuo
Hypomorphic mutation in mouse Nppc gene causes retarded bone growth due to impaired endochondral ossification.
Biochemical and biophysical research communications 2008;376(1):186-90.
2008: Kishimoto I; Tokudome T; Horio T; Soeki T; Chusho H; Nakao K; Kangawa K
C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurones.
Journal of neuroendocrinology 2008;20(11):1213-23.
2008: Ogihara Toshio; Fujimoto Akira; Nakao Kazuwa; Saruta Takao;
ARB candesartan and CCB amlodipine in hypertensive patients: the CASE-J trial.
Expert review of cardiovascular therapy 2008;6(9):1195-201.
2008: Hotta Yuhei; Sasaki Sayaka; Konishi Morichika; Kinoshita Hideyuki; Kuwahara Koichiro; Nakao Kazuwa; Itoh Nobuyuki
Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(10):2947-54.
2008: Yamada Nobuko; Katsuura Goro; Tatsuno Ichiro; Asaki Toshiyuki; Kawahara Shigenori; Ebihara Ken; Saito Yasushi; Nakao Kazuwa
Orexin decreases mRNA expressions of NMDA and AMPA receptor subunits in rat primary neuron cultures.
Peptides 2008;29(9):1582-7.
2008: Ogihara Toshio; Nakao Kazuwa; Fukui Tsuguya; Fukiyama Kohshiro; Fujimoto Akira; Ueshima Kenji; Oba Koji; Shimamoto Kazuaki; Matsuoka Hiroaki; Saruta Takao;
The optimal target blood pressure for antihypertensive treatment in Japanese elderly patients with high-risk hypertension: a subanalysis of the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(8):1595-601.
2008: Yamamuro Megumi; Yoshimura Michihiro; Nakayama Masafumi; Abe Koji; Sumida Hitoshi; Sugiyama Seigo; Saito Yoshihiko; Nakao Kazuwa; Yasue Hirofumi; Ogawa Hisao
Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(8):1346-50.
2008: Arai Hiroshi; Kobayashi Nozomi; Nakatsuru Yuko; Masuzaki Hiroaki; Nambu Takuo; Takaya Kazuhiko; Yamanaka Yusuke; Kondo Eri; Yamada Go; Fujii Toshihito; Miura Masako; Komatsu Yasato; Kanamoto Naotetsu; Ariyasu Hiroyuki; Moriyama Kenji; Yasoda Akihiro; Nakao Kazuwa
A case of cortisol producing adrenal adenoma without phenotype of Cushing's syndrome due to impaired 11beta-hydroxysteroid dehydrogenase 1 activity.
Endocrine journal 2008;55(4):709-15.
2008: Oyamada Naofumi; Sone Masakatsu; Miyashita Kazutoshi; Park Kwijun; Taura Daisuke; Inuzuka Megumi; Sonoyama Takuhiro; Tsujimoto Hirokazu; Fukunaga Yasutomo; Tamura Naohisa; Itoh Hiroshi; Nakao Kazuwa
The role of mineralocorticoid receptor expression in brain remodeling after cerebral ischemia.
Endocrinology 2008;149(8):3764-77.
2008: Nagae T; Mori K; Mukoyama M; Kasahara M; Yokoi H; Suganami T; Sawai K; Yoshioka T; Koshikawa M; Saito Y; Ogawa Y; Kuwabara T; Tanaka I; Sugawara A; Kuwahara T; Nakao K
Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis.
Kidney international 2008;74(1):70-80.
2008: Ariyasu Hiroyuki; Iwakura Hiroshi; Yamada Go; Nakao Kazuwa; Kangawa Kenji; Akamizu Takashi
Efficacy of ghrelin as a therapeutic approach for age-related physiological changes.
Endocrinology 2008;149(7):3722-8.
2008: Zhang Qingfen; Saito Yoshihiko; Naya Noriyuki; Imagawa Keiichi; Somekawa Satoshi; Kawata Hiroyuki; Takeda Yukiji; Uemura Shiro; Kishimoto Ichiro; Nakao Kazuwa
The specific mineralocorticoid receptor blocker eplerenone attenuates left ventricular remodeling in mice lacking the gene encoding guanylyl cyclase-A.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(6):1251-6.
2008: Yura Shigeo; Itoh Hiroaki; Sagawa Norimasa; Yamamoto Hiroshi; Masuzaki Hiroaki; Nakao Kazuwa; Kawamura Makoto; Mogami Haruta; Ogawa Yoshihiro; Fujii Shingo
Neonatal exposure to leptin augments diet-induced obesity in leptin-deficient Ob/Ob mice.
Obesity (Silver Spring, Md.) 2008;16(6):1289-95.
2008: Tokudome Takeshi; Kishimoto Ichiro; Horio Takeshi; Arai Yuji; Schwenke Daryl O; Hino Jun; Okano Ichiro; Kawano Yuhei; Kohno Masakazu; Miyazato Mikiya; Nakao Kazuwa; Kangawa Kenji
Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart.
Circulation 2008;117(18):2329-39.
2008: Ikeda Keiichi; Tojo Katsuyoshi; Udagawa Takashi; Otsubo Chikara; Ishikawa Masahiro; Tokudome Goro; Hosoya Tatsuo; Tajima Naoko; Nakao Kazuwa; Kawamura Masahiro
Cellular physiology of rat cardiac myocytes in cardiac fibrosis: in vitro simulation using the cardiac myocyte/cardiac non-myocyte co-culture system.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(4):693-706.
2008: Majima Takafumi; Komatsu Yasato; Shimatsu Akira; Satoh Noriko; Fukao Atsushi; Ninomiya Kiyoshi; Matsumura Tadashi; Nakao Kazuwa
Efficacy of combined treatment with raloxifene and alfacalcidol on bone density and biochemical markers of bone turnover in postmenopausal osteoporosis.
Endocrine journal 2008;55(1):127-34.
2008: Majima Takafumi; Shimatsu Akira; Komatsu Yasato; Satoh Noriko; Fukao Atsushi; Ninomiya Kiyoshi; Matsumura Tadashi; Nakao Kazuwa
Increased bone turnover in patients with hypercholesterolemia.
Endocrine journal 2008;55(1):143-51.
2008: Majima Takafumi; Shimatsu Akira; Komatsu Yasato; Satoh Noriko; Fukao Atsushi; Ninomiya Kiyoshi; Matsumura Tadashi; Nakao Kazuwa
Association between baseline values of bone turnover markers and bone mineral density and their response to raloxifene treatment in Japanese postmenopausal women with osteoporosis.
Endocrine journal 2008;55(1):41-8.
2008: Ogihara Toshio; Nakao Kazuwa; Fukui Tsuguya; Fukiyama Kohshiro; Ueshima Kenji; Oba Koji; Sato Tosiya; Saruta Takao;
Effects of candesartan compared with amlodipine in hypertensive patients with high cardiovascular risks: candesartan antihypertensive survival evaluation in Japan trial.
Hypertension 2008;51(2):393-8.
2008: Yokoi H; Mukoyama M; Mori K; Kasahara M; Suganami T; Sawai K; Yoshioka T; Saito Y; Ogawa Y; Kuwabara T; Sugawara A; Nakao K
Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice.
Kidney international 2008;73(4):446-55.
2008: Kato Norihiro; Miyata Toshiyuki; Tabara Yasuharu; Katsuya Tomohiro; Yanai Kazuyuki; Hanada Hironori; Kamide Kei; Nakura Jun; Kohara Katsuhiko; Takeuchi Fumihiko; Mano Hiroyuki; Yasunami Michio; Kimura Akinori; Kita Yoshikuni; Ueshima Hirotsugu; Nakayama Tomohiro; Soma Masayoshi; Hata Akira; Fujioka Akihiro; Kawano Yuhei; Nakao Kazuwa; Sekine Akihiro; Yoshida Teruhiko; Nakamura Yusuke; Saruta Takao; Ogihara Toshio; Sugano Sumio; Miki Tetsuro; Tomoike Hitonobu
High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project.
Human molecular genetics 2008;17(4):617-27.
2008: Park Kwijun; Itoh Hiroshi; Yamahara Kenichi; Sone Masakatsu; Miyashita Kazutoshi; Oyamada Naofumi; Sawada Naoya; Taura Daisuke; Inuzuka Megumi; Sonoyama Takuhiro; Tsujimoto Hirokazu; Fukunaga Yasutomo; Tamura Naohisa; Nakao Kazuwa
Therapeutic potential of atrial natriuretic peptide administration on peripheral arterial diseases.
Endocrinology 2008;149(2):483-91.
2008: Usami Satoru; Kishimoto Ichiro; Saito Yoshihiko; Harada Masaki; Kuwahara Koichiro; Nakagawa Yasuaki; Nakanishi Michio; Yasuno Shinji; Kangawa Kenji; Nakao Kazuwa
Association of CT dinucleotide repeat polymorphism in the 5'-flanking region of the guanylyl cyclase (GC)-A gene with essential hypertension in the Japanese.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(1):89-96.
2008: Oyamada Naofumi; Itoh Hiroshi; Sone Masakatsu; Yamahara Kenichi; Miyashita Kazutoshi; Park Kwijun; Taura Daisuke; Inuzuka Megumi; Sonoyama Takuhiro; Tsujimoto Hirokazu; Fukunaga Yasutomo; Tamura Naohisa; Nakao Kazuwa
Transplantation of vascular cells derived from human embryonic stem cells contributes to vascular regeneration after stroke in mice.
Journal of translational medicine 2008;6():54.
2008: Hotta Kikuko; Nakamura Michihiro; Nakata Yoshio; Matsuo Tomoaki; Kamohara Seika; Kotani Kazuaki; Komatsu Ryoya; Itoh Naoto; Mineo Ikuo; Wada Jun; Masuzaki Hiroaki; Yoneda Masato; Nakajima Atsushi; Miyazaki Shigeru; Tokunaga Katsuto; Kawamoto Manabu; Funahashi Tohru; Hamaguchi Kazuyuki; Yamada Kentaro; Hanafusa Toshiaki; Oikawa Shinichi; Yoshimatsu Hironobu; Nakao Kazuwa; Sakata Toshiie; Matsuzawa Yuji; Tanaka Kiyoji; Kamatani Naoyuki; Nakamura Yusuke
INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.
Journal of human genetics 2008;53(9):857-62.
2008: Majima Takafumi; Shimatsu Akira; Komatsu Yasato; Satoh Noriko; Fukao Atsushi; Ninomiya Kiyoshi; Matsumura Tadashi; Nakao Kazuwa
Efficacy of risedronate in Japanese male patients with primary osteoporosis.
Internal medicine (Tokyo, Japan) 2008;47(8):717-23.
2008: Hotta Kikuko; Nakata Yoshio; Matsuo Tomoaki; Kamohara Seika; Kotani Kazuaki; Komatsu Ryoya; Itoh Naoto; Mineo Ikuo; Wada Jun; Masuzaki Hiroaki; Yoneda Masato; Nakajima Atsushi; Miyazaki Shigeru; Tokunaga Katsuto; Kawamoto Manabu; Funahashi Tohru; Hamaguchi Kazuyuki; Yamada Kentaro; Hanafusa Toshiaki; Oikawa Shinichi; Yoshimatsu Hironobu; Nakao Kazuwa; Sakata Toshiie; Matsuzawa Yuji; Tanaka Kiyoji; Kamatani Naoyuki; Nakamura Yusuke
Variations in the FTO gene are associated with severe obesity in the Japanese.
Journal of human genetics 2008;53(6):546-53.
2008: Majima Takafumi; Shimatsu Akira; Satoh Noriko; Komatsu Yasato; Fukao Atsushi; Ninomiya Kiyoshi; Matsumura Tadashi; Nakao Kazuwa
Three-month changes in bone turnover markers and bone mineral density response to raloxifene in Japanese postmenopausal women with osteoporosis.
Journal of bone and mineral metabolism 2008;26(2):178-84.
2008: Yamahara Kenichi; Sone Masakatsu; Itoh Hiroshi; Yamashita Jun K; Yurugi-Kobayashi Takami; Homma Koichiro; Chao Ting-Hsing; Miyashita Kazutoshi; Park Kwijun; Oyamada Naofumi; Sawada Naoya; Taura Daisuke; Fukunaga Yasutomo; Tamura Naohisa; Nakao Kazuwa
Augmentation of neovascularization [corrected] in hindlimb ischemia by combined transplantation of human embryonic stem cells-derived endothelial and mural cells.
PloS one 2008;3(2):e1666.
2007: Tanaka Satsuki; Hayashi Tatsuya; Toyoda Taro; Hamada Taku; Shimizu Yohei; Hirata Masakazu; Ebihara Ken; Masuzaki Hiroaki; Hosoda Kiminori; Fushiki Tohru; Nakao Kazuwa
High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle.
Metabolism: clinical and experimental 2007;56(12):1719-28.
2007: Arai N; Masuzaki H; Tanaka T; Ishii T; Yasue S; Kobayashi N; Tomita T; Noguchi M; Kusakabe T; Fujikura J; Ebihara K; Hirata M; Hosoda K; Hayashi T; Sawai H; Minokoshi Y; Nakao K
Ceramide and adenosine 5'-monophosphate-activated protein kinase are two novel regulators of 11beta-hydroxysteroid dehydrogenase type 1 expression and activity in cultured preadipocytes.
Endocrinology 2007;148(11):5268-77.
2007: Sone Masakatsu; Itoh Hiroshi; Yamahara Kenichi; Yamashita Jun K; Yurugi-Kobayashi Takami; Nonoguchi Akane; Suzuki Yutaka; Chao Ting-Hsing; Sawada Naoki; Fukunaga Yasutomo; Miyashita Kazutoshi; Park Kwijun; Oyamada Naofumi; Sawada Naoya; Taura Daisuke; Tamura Naohisa; Kondo Yasushi; Nito Shinji; Suemori Hirofumi; Nakatsuji Norio; Nishikawa Shin-ichi; Nakao Kazuwa
Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(10):2127-34.
2007: Fujikura Junji; Hosoda Kiminori; Kawaguchi Yoshiya; Noguchi Michio; Iwakura Hiroshi; Odori Shinji; Mori Eisaku; Tomita Tsutomu; Hirata Masakazu; Ebihara Ken; Masuzaki Hiroaki; Fukuda Akihisa; Furuyama Kenichiro; Tanigaki Kenji; Yabe Daisuke; Nakao Kazuwa
Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(10):2779-91.
2007: Sawai Kazutomo; Mukoyama Masashi; Mori Kiyoshi; Kasahara Masato; Koshikawa Masao; Yokoi Hideki; Yoshioka Tetsuro; Ogawa Yoshihisa; Sugawara Akira; Nishiyama Hiroyuki; Yamada Shigehito; Kuwahara Takashi; Saleem Moin A; Shiota Kohei; Ogawa Osamu; Miyazato Mikiya; Kangawa Kenji; Nakao Kazuwa
Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney.
American journal of physiology. Renal physiology 2007;293(4):F1363-72.
2007: Noguchi Michio; Hosoda Kiminori; Fujikura Junji; Fujimoto Muneya; Iwakura Hiroshi; Tomita Tsutomu; Ishii Takako; Arai Naoki; Hirata Masakazu; Ebihara Ken; Masuzaki Hiroaki; Itoh Hiroshi; Narumiya Shuh; Nakao Kazuwa
Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis.
The Journal of biological chemistry 2007;282(40):29574-83.
2007: Iwakura Hiroshi; Akamizu Takashi; Ariyasu Hiroyuki; Irako Taiga; Hosoda Kiminori; Nakao Kazuwa; Kangawa Kenji
Effects of ghrelin administration on decreased growth hormone status in obese animals.
American journal of physiology. Endocrinology and metabolism 2007;293(3):E819-25.
2007: Nakanishi Michio; Harada Masaki; Kishimoto Ichiro; Kuwahara Koichiro; Kawakami Rika; Nakagawa Yasuaki; Yasuno Shinji; Usami Satoru; Kinoshita Hideyuki; Adachi Yuichiro; Fukamizu Akiyoshi; Saito Yoshihiko; Nakao Kazuwa
Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(8):1310-6.
2007: Hataya Yuji; Akamizu Takashi; Kanamoto Naotetsu; Moriyama Kenji; Shimatsu Akira; Nakao Kazuwa
A case of subclinical hypothyroidism developing marked pleural effusions and peripheral edema with elevated vascular endothelial growth factor.
Endocrine journal 2007;54(4):577-84.
2007: Nishijima Tsunenori; Nakayama Masafumi; Yoshimura Michihiro; Abe Koji; Yamamuro Megumi; Suzuki Satoru; Shono Makoto; Sugiyama Seigo; Saito Yoshihiko; Miyamoto Yoshihiro; Nakao Kazuwa; Yasue Hirofumi; Ogawa Hisao
The endothelial nitric oxide synthase gene -786T/C polymorphism is a predictive factor for reattacks of coronary spasm.
Pharmacogenetics and genomics 2007;17(8):581-7.
2007: Nakanishi Michio; Harada Masaki; Tadamura Eiji; Kotani Hirokazu; Kawakami Rika; Kuwahara Koichiro; Nakagawa Yasuaki; Usami Satoru; Kinoshita Hideyuki; Fujiwara Masataka; Hosoda Kiminori; Ueshima Kenji; Nakao Kazuwa
Images in cardiovascular medicine. Mitochondrial cardiomyopathy evaluated with cardiac magnetic resonance.
Circulation 2007;116(2):e25-6.
2007: Shono Makoto; Yoshimura Michihiro; Nakayama Masafumi; Yamamuro Megumi; Abe Koji; Suzuki Satoru; Mizuno Yuji; Sugiyama Seigo; Saito Yoshihiko; Nakao Kazuwa; Yasue Hirofumi; Ogawa Hisao
Predominant effect of A-type natriuretic peptide on reduction of oxidative stress during the treatment of patients with heart failure.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(7):1040-6.
2007: Ito Tetsuhide; Tanaka Masao; Sasano Hironobu; Osamura Yoshiyuki R; Sasaki Iwao; Kimura Wataru; Takano Koji; Obara Takao; Ishibashi Miyuki; Nakao Kazuwa; Doi Ryuichiro; Shimatsu Akira; Nishida Toshirou; Komoto Izumi; Hirata Yukio; Imamura Masayuki; Kawabe Ken; Nakamura Kazuhiko;
Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors.
Journal of gastroenterology 2007;42(6):497-500.
2007: Harada Masaki; Nakao Kazuwa
[Therapeutic application of atrial natriuretic peptide for congestive heart failure]
Nippon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 5():115-9.
2007: Tanaka Tomohiro; Masuzaki Hiroaki; Yasue Shintaro; Ebihara Ken; Shiuchi Tetsuya; Ishii Takako; Arai Naoki; Hirata Masakazu; Yamamoto Hiroshi; Hayashi Tatsuya; Hosoda Kiminori; Minokoshi Yasuhiko; Nakao Kazuwa
Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet.
Cell metabolism 2007;5(5):395-402.
2007: Mori K; Nakao K
Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage.
Kidney international 2007;71(10):967-70.
2007: Nakano Shigeru; Inada Yoichi; Masuzaki Hiroaki; Tanaka Tomohiro; Yasue Shintaro; Ishii Takako; Arai Naoki; Ebihara Ken; Hosoda Kiminori; Maruyama Kazuyasu; Yamazaki Yoshinobu; Shibata Nobuo; Nakao Kazuwa
Bezafibrate regulates the expression and enzyme activity of 11beta-hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes.
American journal of physiology. Endocrinology and metabolism 2007;292(4):E1213-22.
2007: Yatsu Keisuke; Mizuki Nobuhisa; Hirawa Nobuhito; Oka Akira; Itoh Norihiko; Yamane Takahiro; Ogawa Momoko; Shiwa Tadashi; Tabara Yasuharu; Ohno Shigeaki; Soma Masayoshi; Hata Akira; Nakao Kazuwa; Ueshima Hirotsugu; Ogihara Toshio; Tomoike Hitonobu; Miki Tetsuro; Kimura Akinori; Mano Shuhei; Kulski Jerzy K; Umemura Satoshi; Inoko Hidetoshi
High-resolution mapping for essential hypertension using microsatellite markers.
Hypertension 2007;49(3):446-52.
2007: Moriyama Kenji; Tagami Tetsuya; Usui Takeshi; Naruse Mitsuhide; Nambu Takuo; Hataya Yuji; Kanamoto Naotetsu; Li Yu-Shu; Yasoda Akihiro; Arai Hiroshi; Nakao Kazuwa
Antithyroid drugs inhibit thyroid hormone receptor-mediated transcription.
The Journal of clinical endocrinology and metabolism 2007;92(3):1066-72.
2007: Miyamoto Licht; Toyoda Taro; Hayashi Tatsuya; Yonemitsu Shin; Nakano Masako; Tanaka Satsuki; Ebihara Ken; Masuzaki Hiroaki; Hosoda Kiminori; Ogawa Yoshihiro; Inoue Gen; Fushiki Tohru; Nakao Kazuwa
Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;102(3):1007-13.
2007: Ishii Takako; Masuzaki Hiroaki; Tanaka Tomohiro; Arai Naoki; Yasue Shintaro; Kobayashi Nozomi; Tomita Tsutomu; Noguchi Michio; Fujikura Junji; Ebihara Ken; Hosoda Kiminori; Nakao Kazuwa
Augmentation of 11beta-hydroxysteroid dehydrogenase type 1 in LPS-activated J774.1 macrophages--role of 11beta-HSD1 in pro-inflammatory properties in macrophages.
FEBS letters 2007;581(3):349-54.
2007: Majima Takafumi; Komatsu Yasato; Fukao Atsushi; Ninomiya Kiyoshi; Matsumura Tadashi; Nakao Kazuwa
Short-term effects of atorvastatin on bone turnover in male patients with hypercholesterolemia.
Endocrine journal 2007;54(1):145-51.
2007: Kuratomi Shinobu; Kuratomi Akiko; Kuwahara Koichiro; Ishii Takahiro M; Nakao Kazuwa; Saito Yoshihiko; Takano Makoto
NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes.
Biochemical and biophysical research communications 2007;353(1):67-73.
2007: Fujikura Junji; Hosoda Kiminori; Noguchi Michio; Ebihara Ken; Masuzaki Hiroaki; Hirata Masakazu; Fujimoto Koji; Doi Ryuichiro; Iwanishi Masanori; Nakao Kazuwa
A case of secretin-responsive insulinoma with low serum C-peptide levels.
Endocrine journal 2007;54(1):113-21.
2007: Ebihara Ken; Kusakabe Toru; Hirata Masakazu; Masuzaki Hiroaki; Miyanaga Fumiko; Kobayashi Nozomi; Tanaka Tomohiro; Chusho Hideki; Miyazawa Takashi; Hayashi Tatsuya; Hosoda Kiminori; Ogawa Yoshihiro; DePaoli Alex M; Fukushima Masanori; Nakao Kazuwa
Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy.
The Journal of clinical endocrinology and metabolism 2007;92(2):532-41.
2007: Shimasaki Yukio; Saito Yoshihiko; Yoshimura Michihiro; Kamitani Shigeki; Miyamoto Yoshihiro; Masuda Izuru; Nakayama Masafumi; Mizuno Yuji; Ogawa Hisao; Yasue Hirofumi; Nakao Kazuwa
The effects of long-term smoking on endothelial nitric oxide synthase mRNA expression in human platelets as detected with real-time quantitative RT-PCR.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2007;13(1):43-51.
2007: Majima Takafumi; Shimatsu Akira; Komatsu Yasato; Satoh Noriko; Fukao Atsushi; Ninomiya Kiyoshi; Matsumura Tadashi; Nakao Kazuwa
Short-term effects of pitavastatin on biochemical markers of bone turnover in patients with hypercholesterolemia.
Internal medicine (Tokyo, Japan) 2007;46(24):1967-73.
2007: Majima Takafumi; Komatsu Yasato; Shimatsu Akira; Satoh Noriko; Fukao Atsushi; Ninomiya Kiyoshi; Matsumura Tadashi; Nakao Kazuwa
Clinical significance of 1-year treatment with raloxifene on bone and lipid metabolism in Japanese postmenopausal women with osteoporosis.
Endocrine journal 2007;54(6):855-62.
2006: Ariyasu Hiroyuki; Nakao Kazuwa
[Anorexia of aging]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():760-4.
2006: Kusakabe Toru; Ebihara Ken; Nakao Kazuwa
[Efficacy of leptin-replacement therapy in patients with lipoatrophic diabetes]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():737-41.
2006: Masuzaki Hiroaki; Ishii Takako; Nakao Kazuwa
[Intracellular glucocorticoid reactivating enzyme, 11beta-HSD1 as a promising drug target against metabolic syndrome]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():690-6.
2006: Kobayashi Nozomi; Masuzaki Hiroaki; Tanaka Tomohiro; Nakao Kazuwa
[The urinary index of intracellular glucocorticoid reactivation--a novel marker of metabolic syndrome and type 2 diabetes]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():544-50.
2006: Ebihara Ken; Nakao Kazuwa
[Lipotoxicity and metabolic syndrome]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():305-10.
2006: Masuzaki Hiroaki; Yasue Shintaro; Nakao Kazuwa
[Adiposteroid: pathophysiologic role of intracellular glucocorticoid reamplification in adipocytes]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():192-7.
2006: Tanaka Tomohiro; Masuzaki Hiroaki; Nakao Kazuwa
[Adipocyte dysfunction and insulin resistance]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():149-57.
2006: Ebihara Ken; Nakao Kazuwa
[Leptin and feeding regulation]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():103-9.
2006: Miyawaki Takashi; Hirata Masakazu; Nakao Kazuwa; Moriyama Kenji
[Prevalence of metabolic syndrome in Japan by MONKS (metabolic syndrome and abdominal obesity at NTT West Kyoto Study)]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():84-8.
2006: Masuzaki Hiroaki; Tanaka Tomohiro; Nakao Kazuwa
[Metabolic syndrome: convergence of metabolic diseases based on obesity and dysfunction of adipose tissue]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():17-22.
2006: Nakao Kazuwa
[Significance and future problem of metabolic syndrome as a modern illness]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():1-6.
2006: Nakagawa Yasuaki; Kuwahara Koichiro; Harada Masaki; Takahashi Nobuki; Yasuno Shinji; Adachi Yuichiro; Kawakami Rika; Nakanishi Michio; Tanimoto Keiji; Usami Satoru; Kinoshita Hideyuki; Saito Yoshihiko; Nakao Kazuwa
Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes.
Journal of molecular and cellular cardiology 2006;41(6):1010-22.
2006: Makino Hisashi; Miyamoto Yoshihiro; Sawai Kazutomo; Mori Kiyoshi; Mukoyama Masashi; Nakao Kazuwa; Yoshimasa Yasunao; Suga Shin-ichi
Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone.
Diabetes 2006;55(10):2747-56.
2006: Makino H; Mukoyama M; Mori K; Suganami T; Kasahara M; Yahata K; Nagae T; Yokoi H; Sawai K; Ogawa Y; Suga S; Yoshimasa Y; Sugawara A; Tanaka I; Nakao K
Transgenic overexpression of brain natriuretic peptide prevents the progression of diabetic nephropathy in mice.
Diabetologia 2006;49(10):2514-24.
2006: Tanaka Tomohiro; Masuzaki Hiroaki; Ebihara Ken; Nakao Kazuwa
[Clinical and biological consequences of leptin receptor mutation]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 3():241-8.
2006: Ebihara Ken; Nakao Kazuwa
[Congenital leptin deficiency]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 3():235-40.
2006: Kusakabe Toru; Ebihara Ken; Nakao Kazuwa
[Lipoatrophic diabetes]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 3():110-3.
2006: Fujikura Junji; Hosoda Kiminori; Iwakura Hiroshi; Noguchi Michio; Nakao Kazuwa
[Diabetes secondary to endocrinopathies]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 3():73-7.
2006: Sawai Kazutomo; Mukoyama Masashi; Mori Kiyoshi; Yokoi Hideki; Koshikawa Masao; Yoshioka Tetsuro; Takeda Ryuji; Sugawara Akira; Kuwahara Takashi; Saleem Moin A; Ogawa Osamu; Nakao Kazuwa
Redistribution of connexin43 expression in glomerular podocytes predicts poor renal prognosis in patients with type 2 diabetes and overt nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006;21(9):2472-7.
2006: Yurugi-Kobayashi Takami; Itoh Hiroshi; Schroeder Timm; Nakano Akiko; Narazaki Genta; Kita Fumiyo; Yanagi Kentoku; Hiraoka-Kanie Mina; Inoue Emi; Ara Toshiaki; Nagasawa Takashi; Just Ursula; Nakao Kazuwa; Nishikawa Shin-ichi; Yamashita Jun K
Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(9):1977-84.
2006: Ebihara Ken; Nakao Kazuwa
[Leptin gene and leptin receptor gene]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():391-5.
2006: Tamura Naohisa; Nakao Kazuwa
[Significance of natriuretic peptides and their receptors]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():117-21.
2006: Majima Takafumi; Komatsu Yasato; Doi Kentaro; Shigemoto Michika; Takagi Chieko; Fukao Atsushi; Corners Jerry; Nakao Kazuwa
Safety and efficacy of low-dose pioglitazone (7.5 mg/day) vs. standard-dose pioglitazone (15 mg/day) in Japanese women with type 2 diabetes mellitus.
Endocrine journal 2006;53(3):325-30.
2006: Tamura Naohisa; Nakao Kazuwa
[Myelolipoma]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 1():747-9.
2006: Tamura Naohisa; Nakao Kazuwa
[Familial pheochromocytoma]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 1():730-4.
2006: Arai Hiroshi; Nakao Kazuwa
[Pheochromocytoma]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 1():724-9.
2006: Mukoyama Masashi; Nakao Kazuwa
[Selective hypoaldosteronism]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 1():655-60.
2006: Miyashita Kazutoshi; Itoh Hiroshi; Nakao Kazuwa
[Idiopathic hyperaldosteronism (IHA)]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 1():624-7.
2006: Miyashita Kazutoshi; Itoh Hiroshi; Nakao Kazuwa
[ACTH-independent macronodular adrenal hyperplasia]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 1():614-7.
2006: Tamura Naohisa; Nakao Kazuwa
[Corticosteroid withdrawal syndrome]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 1():562-5.
2006: Mukoyama Masashi; Nakao Kazuwa
[Syndrome of inappropriate secretion of antidiuretic hormone]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 1():200-5.
2006: Kanamoto Naotetsu; Arai Hiroshi; Nakao Kazuwa
[TSH-secreting pituitary adenoma]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 1():125-8.
2006: Ariyasu Hiroyuki; Nakao Kazuwa
[Pituitary apoplexy]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 1():49-51.
2006: Mukouyama Masashi; Mori Kiyoshi; Kasahara Masato; Nakao Kazuwa
[Vasoactive substances and water-electrolyte metabolism]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2006;95(5):899-907.
2006: Nishimura Takafumi; Nishida Naoshi; Komeda Toshiki; Fukuda Yoshihiro; Ikai Iwao; Yamaoka Yoshio; Nakao Kazuwa
Genome-wide semiquantitative microsatellite analysis of human hepatocellular carcinoma: discrete mapping of smallest region of overlap of recurrent chromosomal gains and losses.
Cancer genetics and cytogenetics 2006;167(1):57-65.
2006: Nakayama Masafumi; Yoshimura Michihiro; Sakamoto Tomohiro; Abe Koji; Yamamuro Megumi; Shono Makoto; Suzuki Satoru; Nishijima Tsunenori; Miyamoto Yoshihiro; Saito Yoshihiko; Nakao Kazuwa; Yasue Hirofumi; Ogawa Hisao
A -786T>C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite/nitrate levels from the heart due to an intracoronary injection of acetylcholine.
Pharmacogenetics and genomics 2006;16(5):339-45.
2006: Tomita T; Masuzaki H; Iwakura H; Fujikura J; Noguchi M; Tanaka T; Ebihara K; Kawamura J; Komoto I; Kawaguchi Y; Fujimoto K; Doi R; Shimada Y; Hosoda K; Imamura M; Nakao K
Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.
Diabetologia 2006;49(5):962-8.
2006: Ito Hiroshi; Miyashita Kazutoshi; Nakao Kazuwa
[Primary aldosteronism]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2006;95(4):634-41.
2006: Miyashita Kazutoshi; Itoh Hiroshi; Arai Hiroshi; Suganami Takayasu; Sawada Naoki; Fukunaga Yasutomo; Sone Masakatsu; Yamahara Kenichi; Yurugi-Kobayashi Takami; Park Kwijun; Oyamada Naofumi; Sawada Naoya; Taura Daisuke; Tsujimoto Hirokazu; Chao Ting-Hsing; Tamura Naohisa; Mukoyama Masashi; Nakao Kazuwa
The neuroprotective and vasculo-neuro-regenerative roles of adrenomedullin in ischemic brain and its therapeutic potential.
Endocrinology 2006;147(4):1642-53.
2006: Nakano Masako; Hamada Taku; Hayashi Tatsuya; Yonemitsu Shin; Miyamoto Licht; Toyoda Taro; Tanaka Satsuki; Masuzaki Hiroaki; Ebihara Ken; Ogawa Yoshihiro; Hosoda Kiminori; Inoue Gen; Yoshimasa Yasunao; Otaka Akira; Fushiki Toru; Nakao Kazuwa
alpha2 Isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle.
Metabolism: clinical and experimental 2006;55(3):300-8.
2006: Yamamuro Megumi; Yoshimura Michihiro; Nakayama Masafumi; Abe Koji; Shono Makoto; Suzuki Satoru; Sakamoto Tomohiro; Saito Yoshihiko; Nakao Kazuwa; Yasue Hirofumi; Ogawa Hisao
Direct effects of aldosterone on cardiomyocytes in the presence of normal and elevated extracellular sodium.
Endocrinology 2006;147(3):1314-21.
2006: Toyoda Taro; Tanaka Satsuki; Ebihara Ken; Masuzaki Hiroaki; Hosoda Kiminori; Sato Kenji; Fushiki Tohru; Nakao Kazuwa; Hayashi Tatsuya
Low-intensity contraction activates the alpha1-isoform of 5'-AMP-activated protein kinase in rat skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2006;290(3):E583-90.
2006: Moriyama Kenji; Kanamoto Naotetsu; Hataya Yuji; Nanbu Takuo; Hosoda Kiminori; Arai Hiroshi; Nakao Kazuwa
A case of type 2 diabetes mellitus developing hypothyroidism discovered as a result of a discrepancy between glycated hemoglobin and glycated albumin values.
Diabetes research and clinical practice 2006;71(3):227-32.
2006: Mukoyama Masashi; Nakao Kazuwa; Kasahara Masato
[Molecular biology in regulation of kidney functions: Natriuretic peptide system]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 2():192-8.
2006: Tadamura Eiji; Yamamuro Masaki; Kubo Shigeto; Kanao Shotaro; Harada Masaki; Nakao Kazuwa; Komeda Masashi; Togashi Kaori
Images in cardiovascular medicine. Hibernating myocardium identified by cardiovascular magnetic resonance and positron emission tomography.
Circulation 2006;113(7):e158-9.
2006: Fujikura Junji; Hosoda Kiminori; Iwakura Hiroshi; Tomita Tsutomu; Noguchi Michio; Masuzaki Hiroaki; Tanigaki Kenji; Yabe Daisuke; Honjo Tasuku; Nakao Kazuwa
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas.
Cell metabolism 2006;3(1):59-65.
2006: Natsui Koshi; Tanaka Kiyoshi; Suda Michio; Yasoda Akihiro; Sakuma Yoko; Ozasa Ami; Ozaki Shoichi; Nakao Kazuwa
High-dose glucocorticoid treatment induces rapid loss of trabecular bone mineral density and lean body mass.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2006;17(1):105-8.
2006: Majima T; Komatsu Y; Doi K; Takagi C; Shigemoto M; Fukao A; Morimoto T; Corners J; Nakao K
Negative correlation between bone mineral density and TSH receptor antibodies in male patients with untreated Graves' disease.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2006;17(7):1103-10.
2006: Majima Takafumi; Komatsu Yasato; Doi Kentaro; Takagi Chieko; Shigemoto Michika; Fukao Atsushi; Morimoto Takeshi; Corners Jerry; Nakao Kazuwa
Clinical significance of risedronate for osteoporosis in the initial treatment of male patients with Graves' disease.
Journal of bone and mineral metabolism 2006;24(2):105-13.
2005: Miyamoto Yoshihiro; Yoshimasa Yasunao; Nakao Kazuwa
[Genetic testing and gene-based testing of life-style related disease]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():275-9.
2005: Tomita Tsutomu; Masuzaki Hiroaki; Noguchi Michio; Iwakura Hiroshi; Fujikura Junji; Tanaka Tomohiro; Ebihara Ken; Kawamura Junichiro; Komoto Izumi; Kawaguchi Yoshiya; Fujimoto Koji; Doi Ryuichiro; Shimada Yutaka; Hosoda Kiminori; Imamura Masayuki; Nakao Kazuwa
GPR40 gene expression in human pancreas and insulinoma.
Biochemical and biophysical research communications 2005;338(4):1788-90.
2005: Nambu Takuo; Arai Hiroshi; Komatsu Yasato; Yasoda Akihiro; Moriyama Kenji; Kanamoto Naotetsu; Itoh Hiroshi; Nakao Kazuwa
Expression of the adrenomedullin gene in adipose tissue.
Regulatory peptides 2005;132(1-3):17-22.
2005: Ikeda Keiichi; Tojo Katsuyoshi; Otsubo Chikara; Udagawa Takashi; Hosoya Tatsuo; Tajima Naoko; Nakao Kazuwa; Kawamura Masahiro
Effects of urocortin II on neonatal rat cardiac myocytes and non-myocytes.
Peptides 2005;26(12):2473-81.
2005: Kuwahara Koichiro; Takano Makoto; Nakao Kazuwa
Pathophysiological significance of T-type Ca2+ channels: transcriptional regulation of T-type Ca2+ channel--regulation of CACNA1H by neuron-restrictive silencer factor.
Journal of pharmacological sciences 2005;99(3):211-3.
2005: Tanaka Tomohiro; Masuzaki Hiroaki; Ebihara Ken; Ogawa Yoshihiro; Yasue Shintaro; Yukioka Hideo; Chusho Hideki; Miyanaga Fumiko; Miyazawa Takashi; Fujimoto Muneya; Kusakabe Toru; Kobayashi Nozomi; Hayashi Tatsuya; Hosoda Kiminori; Nakao Kazuwa
Transgenic expression of mutant peroxisome proliferator-activated receptor gamma in liver precipitates fasting-induced steatosis but protects against high-fat diet-induced steatosis in mice.
Metabolism: clinical and experimental 2005;54(11):1490-8.
2005: Tanimoto Keiji; Saito Yoshihiko; Hamanaka Ichiro; Kuwahara Koichiro; Harada Masaki; Takahashi Nobuki; Kawakami Rika; Nakagawa Yasuaki; Nakanishi Michio; Adachi Yuichiro; Shirakami Gotaro; Fukuda Kazuhiko; Yoshimura Akihiko; Nakao Kazuwa
SOCS1/JAB likely mediates the protective effect of cardiotrophin-1 against lipopolysaccharide-induced left ventricular dysfunction in vivo.
Circulation journal : official journal of the Japanese Circulation Society 2005;69(11):1412-7.
2005: Fujikura Junji; Fujimoto Muneya; Yasue Shintaro; Noguchi Michio; Masuzaki Hiroaki; Hosoda Kiminori; Tachibana Takao; Sugihara Hajime; Nakao Kazuwa
Insulin-induced lipohypertrophy: report of a case with histopathology.
Endocrine journal 2005;52(5):623-8.
2005: Majima Takafumi; Komatsu Yasato; Doi Kentaro; Shigemoto Michika; Takagi Chieko; Fukao Atsushi; Kojima Masatsugu; Tamaki Hisanobu; Ito Juichi; Nakao Kazuwa
Anaplastic thyroid carcinoma associated with Graves' disease.
Endocrine journal 2005;52(5):551-7.
2005: Hamada Koichi; Sasaki Takehiko; Koni Pandelakis A; Natsui Miyuki; Kishimoto Hiroyuki; Sasaki Junko; Yajima Nobuyuki; Horie Yasuo; Hasegawa Go; Naito Makoto; Miyazaki Jun-Ichi; Suda Toshio; Itoh Hiroshi; Nakao Kazuwa; Mak Tak Wah; Nakano Toru; Suzuki Akira
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.
Genes & development 2005;19(17):2054-65.
2005: Nishimura Takafumi; Nishida Naoshi; Komeda Toshiki; Fukuda Yoshihiro; Nakao Kazuwa
Genotype stability and clonal evolution of hepatocellular carcinoma assessed by autopsy-based genome-wide microsatellite analysis.
Cancer genetics and cytogenetics 2005;161(2):164-9.
2005: Koshikawa Masao; Mukoyama Masashi; Mori Kiyoshi; Suganami Takayoshi; Sawai Kazutomo; Yoshioka Tetsuro; Nagae Tetsuya; Yokoi Hideki; Kawachi Hiroshi; Shimizu Fujio; Sugawara Akira; Nakao Kazuwa
Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome.
Journal of the American Society of Nephrology : JASN 2005;16(9):2690-701.
2005: Fujimoto Muneya; Masuzaki Hiroaki; Yamamoto Yuji; Norisada Nobuyoshi; Imori Makoto; Yoshimoto Masako; Tomita Tsutomu; Tanaka Tomohiro; Okazawa Kayoko; Fujikura Junji; Chusho Hideki; Ebihara Ken; Hayashi Tatsuya; Hosoda Kiminori; Inoue Gen; Nakao Kazuwa
CCAAT/enhancer binding protein alpha maintains the ability of insulin-stimulated GLUT4 translocation in 3T3-C2 fibroblastic cells.
Biochimica et biophysica acta 2005;1745(1):38-47.
2005: Tanaka Tomohiro; Hidaka Shuji; Masuzaki Hiroaki; Yasue Shintaro; Minokoshi Yasuhiko; Ebihara Ken; Chusho Hideki; Ogawa Yoshihiro; Toyoda Taro; Sato Kenji; Miyanaga Fumiko; Fujimoto Muneya; Tomita Tsutomu; Kusakabe Toru; Kobayashi Nozomi; Tanioka Hideki; Hayashi Tatsuya; Hosoda Kiminori; Yoshimatsu Hironobu; Sakata Toshiie; Nakao Kazuwa
Skeletal muscle AMP-activated protein kinase phosphorylation parallels metabolic phenotype in leptin transgenic mice under dietary modification.
Diabetes 2005;54(8):2365-74.
2005: Nakanishi Michio; Saito Yoshihiko; Kishimoto Ichiro; Harada Masaki; Kuwahara Koichiro; Takahashi Nobuki; Kawakami Rika; Nakagawa Yasuaki; Tanimoto Keiji; Yasuno Shinji; Usami Satoru; Li Yuhao; Adachi Yuichiro; Fukamizu Akiyoshi; Garbers David L; Nakao Kazuwa
Role of natriuretic peptide receptor guanylyl cyclase-A in myocardial infarction evaluated using genetically engineered mice.
Hypertension 2005;46(2):441-7.
2005: Majima T; Komatsu Y; Yamada T; Koike Y; Shigemoto M; Takagi C; Hatanaka I; Nakao K
Decreased bone mineral density at the distal radius, but not at the lumbar spine or the femoral neck, in Japanese type 2 diabetic patients.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2005;16(8):907-13.
2005: Hoshino Mikio; Nakamura Shoko; Mori Kiyoshi; Kawauchi Takeshi; Terao Mami; Nishimura Yoshiaki V; Fukuda Akihisa; Fuse Toshimitsu; Matsuo Naoki; Sone Masaki; Watanabe Masahiko; Bito Haruhiko; Terashima Toshio; Wright Christopher V E; Kawaguchi Yoshiya; Nakao Kazuwa; Nabeshima Yo-Ichi
Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum.
Neuron 2005;47(2):201-13.
2005: Yura Shigeo; Itoh Hiroaki; Sagawa Norimasa; Yamamoto Hiroshi; Masuzaki Hiroaki; Nakao Kazuwa; Kawamura Makoto; Takemura Maki; Kakui Kazuyo; Ogawa Yoshihiro; Fujii Shingo
Role of premature leptin surge in obesity resulting from intrauterine undernutrition.
Cell metabolism 2005;1(6):371-8.
2005: Majima Takafumi; Doi Kentaro; Komatsu Yasato; Itoh Hiroshi; Fukao Atsushi; Shigemoto Michika; Takagi Chieko; Corners Jerry; Mizuta Naomi; Kato Ryohei; Nakao Kazuwa
Papillary thyroid carcinoma without metastases manifesting as an autonomously functioning thyroid nodule.
Endocrine journal 2005;52(3):309-16.
2005: Tokudome Takeshi; Horio Takeshi; Kishimoto Ichiro; Soeki Takeshi; Mori Kenji; Kawano Yuhei; Kohno Masakazu; Garbers David L; Nakao Kazuwa; Kangawa Kenji
Calcineurin-nuclear factor of activated T cells pathway-dependent cardiac remodeling in mice deficient in guanylyl cyclase A, a receptor for atrial and brain natriuretic peptides.
Circulation 2005;111(23):3095-104.
2005: Ozasa Ami; Komatsu Yasato; Yasoda Akihiro; Miura Masako; Sakuma Yoko; Nakatsuru Yuko; Arai Hiroshi; Itoh Nobuyuki; Nakao Kazuwa
Complementary antagonistic actions between C-type natriuretic peptide and the MAPK pathway through FGFR-3 in ATDC5 cells.
Bone 2005;36(6):1056-64.
2005: Abe Koji; Nakayama Masafumi; Yoshimura Michihiro; Nakamura Shota; Ito Teruhiko; Yamamuro Megumi; Sakamoto Tomohiro; Miyamoto Yoshihiro; Yoshimasa Yasunao; Saito Yoshihiko; Nakao Kazuwa; Yasue Hirofumi; Ogawa Hisao
Increase in the transcriptional activity of the endothelial nitric oxide synthase gene with fluvastatin: a relation with the -786T>C polymorphism.
Pharmacogenetics and genomics 2005;15(5):329-36.
2005: Tanaka Tomohiro; Masuzaki Hiroaki; Nakao Kazuwa
[Role of PPARs in the pathophysiology of nonalcoholoic fatty liver disease]
Nippon rinsho. Japanese journal of clinical medicine 2005;63(4):700-6.
2005: Okazawa Kayoko; Yoshimasa Yasunao; Miyamoto Yoshihiro; Takahashi-Yasuno Akiko; Miyawaki Takashi; Masuzaki Hiroaki; Hayashi Tatsuya; Hosoda Kiminori; Inoue Gen; Nakao Kazuwa
The haplotypes of the IRS-2 gene affect insulin sensitivity in Japanese patients with type 2 diabetes.
Diabetes research and clinical practice 2005;68(1):39-48.
2005: Iwakura Hiroshi; Hosoda Kiminori; Son Choel; Fujikura Junji; Tomita Tsutomu; Noguchi Michio; Ariyasu Hiroyuki; Takaya Kazuhiko; Masuzaki Hiroaki; Ogawa Yoshihiro; Hayashi Tatsuya; Inoue Gen; Akamizu Takashi; Hosoda Hiroshi; Kojima Masayasu; Itoh Hiroshi; Toyokuni Shinya; Kangawa Kenji; Nakao Kazuwa
Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice.
The Journal of biological chemistry 2005;280(15):15247-56.
2005: Saito Takatoshi; Itoh Hiroshi; Yamashita Jun; Doi Kentaro; Chun Tae-Hwa; Tanaka Tokuji; Inoue Mayumi; Masatsugu Ken; Fukunaga Yasutomo; Sawada Naoki; Sakaguchi Satsuki; Arai Hiroshi; Tojo Katsuyoshi; Tajima Naoko; Hosoya Tatsuo; Nakao Kazuwa
Angiotensin II suppresses growth arrest specific homeobox (Gax) expression via redox-sensitive mitogen-activated protein kinase (MAPK).
Regulatory peptides 2005;127(1-3):159-67.
2005: Ikeda Keiichi; Tojo Katsuyoshi; Otsubo Chikara; Udagawa Takashi; Kumazawa Kensuke; Ishikawa Masahiro; Tokudome Goro; Hosoya Tatsuo; Tajima Naoko; Claycomb William C; Nakao Kazuwa; Kawamura Masahiro
5-hydroxytryptamine synthesis in HL-1 cells and neonatal rat cardiocytes.
Biochemical and biophysical research communications 2005;328(2):522-5.
2005: Masuzaki Hiroaki; Nakao Kazuwa
[Obesity and the metabolic syndrome]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 2():264-8.
2005: Mizuno Yuji; Yasue Hirofumi; Yoshimura Michihiro; Harada Eisaku; Fujii Hiromi; Nakamura Shota; Yamamoto Nobuyasu; Ogawa Hisao; Nakao Kazuwa
Adrenocorticotropic hormone is produced in the ventricle of patients with essential hypertension.
Journal of hypertension 2005;23(2):411-6.
2005: Furuto-Kato Sumiko; Matsukura Shigeru; Ogata Makoto; Azuma Nobuyuki; Manabe Toshiaki; Shigeno Chohei; Asato Ryo; Tanaka Kiyoshi; Komatsu Yasato; Nakao Kazuwa
Primary hyperparathyroidism presumably caused by chronic parathyroiditis manifesting from hypocalcemia to severe hypercalcemia.
Internal medicine (Tokyo, Japan) 2005;44(1):60-4.
2005: Tanaka Tokuji; Fukunaga Yasutomo; Itoh Hiroshi; Doi Kentaro; Yamashita Jun; Chun Tae-Hwa; Inoue Mayumi; Masatsugu Ken; Saito Takatoshi; Sawada Naoki; Sakaguchi Satsuki; Arai Hiroshi; Nakao Kazuwa
Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration.
European journal of pharmacology 2005;508(1-3):255-65.
2005: Takahashi Nobuki; Saito Yoshihiko; Kuwahara Koichiro; Harada Masaki; Tanimoto Keiji; Nakagawa Yasuaki; Kawakami Rika; Nakanishi Michio; Yasuno Shinji; Usami Satoru; Yoshimura Akihiko; Nakao Kazuwa
Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes.
Journal of molecular and cellular cardiology 2005;38(1):185-92.
2005: Suganami Takayoshi; Mukoyama Masashi; Mori Kiyoshi; Yokoi Hideki; Koshikawa Masao; Sawai Kazutomo; Hidaka Shuji; Ebihara Ken; Tanaka Tomohiro; Sugawara Akira; Kawachi Hiroshi; Vinson Charles; Ogawa Yoshihiro; Nakao Kazuwa
Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):127-9.
2005: Nishimura Takafumi; Nishida Naoshi; Itoh Teruaki; Komeda Toshiki; Fukuda Yoshihiro; Ikai Iwao; Yamaoka Yoshio; Nakao Kazuwa
Discrete breakpoint mapping and shortest region of overlap of chromosome arm 1q gain and 1p loss in human hepatocellular carcinoma detected by semiquantitative microsatellite analysis.
Genes, chromosomes & cancer 2005;42(1):34-43.
2005: Ariyasu Hiroyuki; Takaya Kazuhiko; Iwakura Hiroshi; Hosoda Hiroshi; Akamizu Takashi; Arai Yuji; Kangawa Kenji; Nakao Kazuwa
Transgenic mice overexpressing des-acyl ghrelin show small phenotype.
Endocrinology 2005;146(1):355-64.
2004: Norisada Nobuyoshi; Masuzaki Hiroaki; Fujimoto Muneya; Inoue Gen; Hosoda Kiminori; Hayashi Tatsuya; Watanabe Mayumi; Muraoka Shizuko; Yoneda Fumio; Nakao Kazuwa
Antidiabetic and adipogenic properties in a newly synthesized thiazolidine derivative, FPFS-410.
Metabolism: clinical and experimental 2004;53(12):1532-7.
2004: Kawakami Rika; Saito Yoshihiko; Kishimoto Ichiro; Harada Masaki; Kuwahara Koichiro; Takahashi Nobuki; Nakagawa Yasuaki; Nakanishi Michio; Tanimoto Keiji; Usami Satoru; Yasuno Shinji; Kinoshita Hideyuki; Chusho Hideki; Tamura Naohisa; Ogawa Yoshihiro; Nakao Kazuwa
Overexpression of brain natriuretic peptide facilitates neutrophil infiltration and cardiac matrix metalloproteinase-9 expression after acute myocardial infarction.
Circulation 2004;110(21):3306-12.
2004: Fujimoto Muneya; Masuzaki Hiroaki; Tanaka Tomohiro; Yasue Shintaro; Tomita Tsutomu; Okazawa Kayoko; Fujikura Junji; Chusho Hideki; Ebihara Ken; Hayashi Tatsuya; Hosoda Kiminori; Nakao Kazuwa
An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3-L1 adipocytes.
FEBS letters 2004;576(3):492-7.
2004: Takaya Kazuhiko; Nakao Kazuwa; Kangawa Kenji
[Roles of ghrelin in growth and aging]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():414-6.
2004: Ariyasu Hiroyuki; Nakao Kazuwa; Kangawa Kenji
[Role of ghrelin in anorexia nervosa]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():410-3.
2004: Komatsu Yasato; Nakao Kazuwa
[Ghrelin and bone metabolism]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():384-7.
2004: Takaya Kazuhiko; Nakao Kazuwa; Kangawa Kenji
[Effects of ghrelin in aged subjects]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():377-9.
2004: Takaya Kazuhiko; Nakao Kazuwa; Kangawa Kenji
[Neuroendocrine effects of ghrelin]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():369-72.
2004: Iwakura Hiroshi; Hosoda Kiminori; Ariyasu Hiroyuki; Takaya Kazuhiko; Nakao Kazuwa
[Genetically engineered mouse models in the ghrelin gene]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():344-6.
2004: Kanamoto Naotetsu; Moriyama Kenji; Nakao Kazuwa; Akamizu Takashi; Tagami Tetsuya
[Mechanism of ghrelin gene expression]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():340-3.
2004: Miyashita Kazutoshi; Itoh Hiroshi; Nakao Kazuwa
[Clinical application of adrenomedullin to therapeutic angiogenesis]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():307-13.
2004: Mukoyama Masashi; Nagae Tetsuya; Yokoi Hideki; Nakao Kazuwa
[Renal actions and renoprotective role of adrenomedullin]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():237-41.
2004: Tamura Naohisa; Harada Masaki; Yamahara Kenichi; Yokoi Hideki; Yasoda Akihiro; Nakao Kazuwa
[Translational research on the natriuretic peptide system]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():157-63.
2004: Park Kwijun; Itoh Hiroshi; Nakao Kazuwa
[Current status and future prospects of C-type natriuretic peptide]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():151-6.
2004: Yamahara Kenichi; Itoh Hiroshi; Nakao Kazuwa
[Natriuretic peptides and atherosclerosis]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():117-20.
2004: Mukoyama Masashi; Suganami Takayoshi; Nakao Kazuwa
[Diuretic and renoprotective effects of natriuretic peptides]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():69-75.
2004: Yasoda Akihiro; Komatsu Yasato; Nakao Kazuwa; Ogawa Yoshihiro
[Growth promoting effect of natriuretic peptides on bones formed through endochondral ossification]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():60-4.
2004: Miyashita Kazutoshi; Itoh Hiroshi; Nakao Kazuwa
[Significant roles of natriuretic peptides in vascular physiology]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():51-5.
2004: Harada Masaki; Nakao Kazuwa
[Measurement of natriuretic peptides]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():47-50.
2004: Tamura Naohisa; Nakao Kazuwa
[Analysis of physiological roles of natriuretic peptides using transgenic animals]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():31-7.
2004: Kuwahara Koichiro; Nakao Kazuwa
[Regulation of natriuretic peptide gene expression]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():28-30.
2004: Nakao Kazuwa; Tamura Naohisa
[Discovery and significance of natriuretic peptides]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():5-9.
2004: Nakamura Shota; Yoshimura Michihiro; Nakayama Masafumi; Ito Teruhiko; Mizuno Yuji; Harada Eisaku; Sakamoto Tomohiro; Saito Yoshihiko; Nakao Kazuwa; Yasue Hirofumi; Ogawa Hisao
Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart.
Circulation 2004;110(13):1787-93.
2004: Suzuki Satoru; Yoshimura Michihiro; Nakayama Masafumi; Mizuno Yuji; Harada Eisaku; Ito Teruhiko; Nakamura Shota; Abe Koji; Yamamuro Megumi; Sakamoto Tomohiro; Saito Yoshihiko; Nakao Kazuwa; Yasue Hirofumi; Ogawa Hisao
Plasma level of B-type natriuretic peptide as a prognostic marker after acute myocardial infarction: a long-term follow-up analysis.
Circulation 2004;110(11):1387-91.
2004: Suganami Eri; Takagi Hitoshi; Ohashi Hirokazu; Suzuma Kiyoshi; Suzuma Izumi; Oh Hideyasu; Watanabe Daisuke; Ojima Tomonari; Suganami Takayoshi; Fujio Yasushi; Nakao Kazuwa; Ogawa Yoshihiro; Yoshimura Nagahisa
Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells.
Diabetes 2004;53(9):2443-8.
2004: Kanamoto Naotetsu; Akamizu Takashi; Tagami Tetsuya; Hataya Yuji; Moriyama Kenji; Takaya Kazuhiko; Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji; Nakao Kazuwa
Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene.
Endocrinology 2004;145(9):4144-53.
2004: Ebihara Ken; Masuzaki Hiroaki; Nakao Kazuwa
Long-term leptin-replacement therapy for lipoatrophic diabetes.
The New England journal of medicine 2004;351(6):615-6.
2004: Toyoda Taro; Hayashi Tatsuya; Miyamoto Licht; Yonemitsu Shin; Nakano Masako; Tanaka Satsuki; Ebihara Ken; Masuzaki Hiroaki; Hosoda Kiminori; Inoue Gen; Otaka Akira; Sato Kenji; Fushiki Tohru; Nakao Kazuwa
Possible involvement of the alpha1 isoform of 5'AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2004;287(1):E166-73.
2004: Masuzaki Hiroaki; Tanaka Tomohiro; Nakao Kazuwa
[Novel transgenic mouse model of the metabolic syndrome]
Nippon rinsho. Japanese journal of clinical medicine 2004;62(6):1059-65.
2004: Yokoi Hideki; Mukoyama Masashi; Nagae Tetsuya; Mori Kiyoshi; Suganami Takayoshi; Sawai Kazutomo; Yoshioka Tetsuro; Koshikawa Masao; Nishida Takashi; Takigawa Masaharu; Sugawara Akira; Nakao Kazuwa
Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis.
Journal of the American Society of Nephrology : JASN 2004;15(6):1430-40.
2004: Takahashi-Yasuno Akiko; Masuzaki Hiroaki; Miyawaki Takashi; Matsuoka Naoki; Ogawa Yoshihiro; Hayashi Tatsuya; Hosoda Kiminori; Yoshimasa Yasunao; Inoue Gen; Nakao Kazuwa
Association of Ob-R gene polymorphism and insulin resistance in Japanese men.
Metabolism: clinical and experimental 2004;53(5):650-4.
2004: Ebihara Ken; Kusakabe Toru; Masuzaki Hiroaki; Kobayashi Nozomi; Tanaka Tomohiro; Chusho Hideki; Miyanaga Fumiko; Miyazawa Takashi; Hayashi Tatsuya; Hosoda Kiminori; Ogawa Yoshihiro; Nakao Kazuwa
Gene and phenotype analysis of congenital generalized lipodystrophy in Japanese: a novel homozygous nonsense mutation in seipin gene.
The Journal of clinical endocrinology and metabolism 2004;89(5):2360-4.
2004: Li Yu-Shu; Kanamoto Naotetsu; Hataya Yuji; Moriyama Kenji; Hiratani Hitomi; Nakao Kazuwa; Akamizu Takashi
Transgenic mice producing major histocompatibility complex class II molecules on thyroid cells do not develop apparent autoimmune thyroid diseases.
Endocrinology 2004;145(5):2524-30.
2004: Nuamah Mercy A; Yura Shigeo; Sagawa Norimasa; Itoh Hiroaki; Mise Hiroko; Korita Daizo; Kakui Kazuyo; Takemura Maki; Ogawa Yoshihiro; Nakao Kazuwa; Fujii Shingo
Significant increase in maternal plasma leptin concentration in induced delivery: a possible contribution of pro-inflammatory cytokines to placental leptin secretion.
Endocrine journal 2004;51(2):177-87.
2004: Ogawa Yoshihiro; Nakao Kazuwa
[Involvement of leptin in the pathogenesis of hypertension and hypertensive target-organ damage]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 3():216-21.
2004: Takahashi Jun A; Shimatsu Akira; Nakao Kazuwa; Hashimoto Nobuo
Early postoperative indicators of late outcome in acromegalic patients.
Clinical endocrinology 2004;60(3):366-74.
2004: Hamada Taku; Hayashi Tatsuya; Kimura Tetsuya; Nakao Kazuwa; Moritani Toshio
Electrical stimulation of human lower extremities enhances energy consumption, carbohydrate oxidation, and whole body glucose uptake.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(3):911-6.
2004: Komatsu Yasato; Nakao Kazuwa
[Stimulation of bone formation by statins]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 2():783-8.
2004: Yasoda Akihiro; Komatsu Yasato; Nakao Kazuwa; Ogawa Yoshihiro
[C-type natriuretic peptide(CNP)--a novel stimulator of bone growth formed through endochondral ossification]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 2():77-81.
2004: Kakui Kazuyo; Itoh Hiroaki; Sagawa Norimasa; Yura Shigeo; Korita Daizo; Takemura Maki; Miyamaoto Yoshihiro; Saito Yoshihiko; Nakao Kazuwa; Fujii Shingo
Augmented endothelial nitric oxide synthase (eNOS) protein expression in human pregnant myometrium: possible involvement of eNOS promoter activation by estrogen via both estrogen receptor (ER)alpha and ERbeta.
Molecular human reproduction 2004;10(2):115-22.
2004: Li Yuhao; Kishimoto Ichiro; Saito Yoshihiko; Harada Masaki; Kuwahara Koichiro; Izumi Takehiko; Hamanaka Ichiro; Takahashi Nobuki; Kawakami Rika; Tanimoto Keiji; Nakagawa Yasuaki; Nakanishi Michio; Adachi Yuichiro; Garbers David L; Fukamizu Akiyoshi; Nakao Kazuwa
Androgen contributes to gender-related cardiac hypertrophy and fibrosis in mice lacking the gene encoding guanylyl cyclase-A.
Endocrinology 2004;145(2):951-8.
2004: Yasoda Akihiro; Komatsu Yasato; Chusho Hideki; Miyazawa Takashi; Ozasa Ami; Miura Masako; Kurihara Tatsuya; Rogi Tomohiro; Tanaka Shoji; Suda Michio; Tamura Naohisa; Ogawa Yoshihiro; Nakao Kazuwa
Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.
Nature medicine 2004;10(1):80-6.
2004: Son C; Hosoda K; Ishihara K; Bevilacqua L; Masuzaki H; Fushiki T; Harper M E; Nakao K
Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle.
Diabetologia 2004;47(1):47-54.
2004: Ito Teruaki; Nishida Naoshi; Fukuda Yoshihiro; Nishimura Takafumi; Komeda Toshiki; Nakao Kazuwa
Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomas.
Journal of gastroenterology 2004;39(4):355-61.
2003: Komatsu Yasato; Yasoda Akihiro; Chusho Hideki; Nakao Kazuwa
[The possible novel treatment of achondroplasia, C-type natriuretic peptide (CNP)]
Clinical calcium 2003;13(12):1578-81.
2003: Suganami Takayoshi; Mori Kiyoshi; Tanaka Issei; Mukoyama Masashi; Sugawara Akira; Makino Hisashi; Muro Seiji; Yahata Kensei; Ohuchida Shuichi; Maruyama Takayuki; Narumiya Shuh; Nakao Kazuwa
Role of prostaglandin E receptor EP1 subtype in the development of renal injury in genetically hypertensive rats.
Hypertension 2003;42(6):1183-90.
2003: Kuwahara Koichiro; Saito Yoshihiko; Takano Makoto; Arai Yuji; Yasuno Shinji; Nakagawa Yasuaki; Takahashi Nobuki; Adachi Yuichiro; Takemura Genzo; Horie Minoru; Miyamoto Yoshihiro; Morisaki Takayuki; Kuratomi Shinobu; Noma Akinori; Fujiwara Hisayoshi; Yoshimasa Yasunao; Kinoshita Hideyuki; Kawakami Rika; Kishimoto Ichiro; Nakanishi Michio; Usami Satoru; Saito Yoshitomo; Harada Masaki; Nakao Kazuwa
NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function.
The EMBO journal 2003;22(23):6310-21.
2003: Takahashi-Yasuno Akiko; Masuzaki Hiroaki; Miyawaki Takashi; Ogawa Yoshihiro; Matsuoka Naoki; Hayashi Tatsuya; Hosoda Kiminori; Inoue Gen; Yoshimasa Yasunao; Nakao Kazuwa
Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men.
Diabetes research and clinical practice 2003;62(3):169-75.
2003: Hataya Yuji; Akamizu Takashi; Hosoda Hiroshi; Kanamoto Naotetsu; Moriyama Kenji; Kangawa Kenji; Takaya Kazuhiko; Nakao Kazuwa
Alterations of plasma ghrelin levels in rats with lipopolysaccharide-induced wasting syndrome and effects of ghrelin treatment on the syndrome.
Endocrinology 2003;144(12):5365-71.
2003: Moriyama K; Okuda J; Saijo M; Hattori Y; Kanamoto N; Hataya Y; Matsuda F; Mori T; Nakao K; Akamizu T
Recombinant monoclonal thyrotropin-stimulation blocking antibody (TSBAb) established from peripheral lymphocytes of a hypothyroid patient with primary myxedema.
Journal of endocrinological investigation 2003;26(11):1076-80.
2003: Nakayama Masafumi; Yoshimura Michihiro; Sakamoto Tomohiro; Shimasaki Yukio; Nakamura Shota; Ito Teruhiko; Abe Koji; Yamamuro Megumi; Miyamoto Yoshihiro; Saito Yoshihiko; Nakao Kazuwa; Yasue Hirofumi; Ogawa Hisao
Synergistic interaction of T-786-->C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasm.
Pharmacogenetics 2003;13(11):683-8.
2003: Iho Sumiko; Tanaka Yukie; Takauji Rumiko; Kobayashi Chino; Muramatsu Ikunobu; Iwasaki Hiromichi; Nakamura Kishiko; Sasaki Yutaka; Nakao Kazuwa; Takahashi Takayuki
Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB.
Journal of leukocyte biology 2003;74(5):942-51.
2003: Takahashi Nobuki; Saito Yoshihiko; Kuwahara Koichiro; Harada Masaki; Kishimoto Ichiro; Ogawa Yoshihiro; Kawakami Rika; Nakagawa Yasuaki; Nakanishi Michio; Nakao Kazuwa
Angiotensin II-induced ventricular hypertrophy and extracellular signal-regulated kinase activation are suppressed in mice overexpressing brain natriuretic peptide in circulation.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26(10):847-53.
2003: Nishizawa Koji; Nakamura Elhiro; Kobayashi Takashi; Kamoto Toshiyuki; Terai Akito; Terachi Toshiro; Ogawa Osamu; Itoh Hiroshi; Nakao Kazuwa
Successful treatment of primary aldosteronism due to computed tomography-negative microadenoma.
International journal of urology : official journal of the Japanese Urological Association 2003;10(10):544-6.
2003: Yahata Kensei; Mori Kiyoshi; Mukoyama Masashi; Sugawara Akira; Suganami Takayoshi; Makino Hisashi; Nagae Tetsuya; Fujinaga Yuriko; Nabeshima Yo-ichi; Nakao Kazuwa
Regulation of stanniocalcin 1 and 2 expression in the kidney by klotho gene.
Biochemical and biophysical research communications 2003;310(1):128-34.
2003: Miyanaga F; Ogawa Y; Ebihara K; Hidaka S; Tanaka T; Hayashi S; Masuzaki H; Nakao K
Leptin as an adjunct of insulin therapy in insulin-deficient diabetes.
Diabetologia 2003;46(10):1329-37.
2003: Komatsu Yasato; Nakajima Ran; Yasoda Akihiro; Nakatsuru Yuko; Arai Hiroshi; Nakao Kazuwa; Shigeno Chohei
[In Process Citation]
Clinical calcium 2003;13(9):1188-92.
2003: Satoh Noriko; Ogawa Yoshihiro; Usui Takeshi; Tagami Tetsuya; Kono Shigeo; Uesugi Hiroko; Sugiyama Hiroyuki; Sugawara Akira; Yamada Kazunori; Shimatsu Akira; Kuzuya Hideshi; Nakao Kazuwa
Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect.
Diabetes care 2003;26(9):2493-9.
2003: Kim-Saijo Misa; Akamizu Takashi; Ikuta Koichi; Iida Yasuhiko; Ohmori Katsuyuki; Matsubara Kazumi; Matsuda Yoichi; Suzuki Misao; Matsuda Fumihiko; Nakao Kazuwa
Generation of a transgenic animal model of hyperthyroid Graves' disease.
European journal of immunology 2003;33(9):2531-8.
2003: Nuamah Mercy A; Sagawa Norimasa; Yura Shigeo; Mise Hiroko; Itoh Hiroaki; Ogawa Yoshihiro; Nakao Kazuwa; Fujii Shingo
Free-to-total leptin ratio in maternal plasma is constant throughout human pregnancy.
Endocrine journal 2003;50(4):421-8.
2003: Nishida N; Nishimura T; Ito T; Komeda T; Fukuda Y; Nakao K
Chromosomal instability and human hepatocarcinogenesis.
Histology and histopathology 2003;18(3):897-909.
2003: Miyashita Kazutoshi; Itoh Hiroshi; Sawada Naoki; Fukunaga Yasutomo; Sone Masakatsu; Yamahara Kenichi; Yurugi-Kobayashi Takami; Park Kwijun; Nakao Kazuwa
Adrenomedullin provokes endothelial Akt activation and promotes vascular regeneration both in vitro and in vivo.
FEBS letters 2003;544(1-3):86-92.
2003: Chun Tae-Hwa; Itoh Hiroshi; Subramanian Lalitha; Iñiguez-Lluhí Jorge A; Nakao Kazuwa
Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy.
Circulation research 2003;92(11):1201-8.
2003: Hamada Taku; Sasaki Hideki; Hayashi Tatsuya; Moritani Toshio; Nakao Kazuwa
Enhancement of whole body glucose uptake during and after human skeletal muscle low-frequency electrical stimulation.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;94(6):2107-12.
2003: Adachi Yuichiro; Saito Yoshihiko; Kishimoto Ichiro; Harada Masaki; Kuwahara Koichiro; Takahashi Nobuki; Kawakami Rika; Nakanishi Michio; Nakagawa Yasuaki; Tanimoto Keiji; Saitoh Yoshitomo; Yasuno Shinji; Usami Satoru; Iwai Masaru; Horiuchi Masatsugu; Nakao Kazuwa
Angiotensin II type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice.
Circulation 2003;107(19):2406-8.
2003: Sawai Kazutomo; Mori Kiyoshi; Mukoyama Masashi; Sugawara Akira; Suganami Takayoshi; Koshikawa Masao; Yahata Kensei; Makino Hisashi; Nagae Tetsuya; Fujinaga Yuriko; Yokoi Hideki; Yoshioka Tetsuro; Yoshimoto Akihiro; Tanaka Issei; Nakao Kazuwa
Angiogenic protein Cyr61 is expressed by podocytes in anti-Thy-1 glomerulonephritis.
Journal of the American Society of Nephrology : JASN 2003;14(5):1154-63.
2003: Chin Kazuo; Nakamura Takaya; Takahashi Kenichi; Sumi Kensuke; Ogawa Yoshihiro; Masuzaki Hiroaki; Muro Shigeo; Hattori Noboru; Matsumoto Hisako; Niimi Akio; Chiba Tsutomu; Nakao Kazuwa; Mishima Michiaki; Ohi Motoharu; Nakamura Takashi
Effects of obstructive sleep apnea syndrome on serum aminotransferase levels in obese patients.
The American journal of medicine 2003;114(5):370-6.
2003: Sone Masakatsu; Itoh Hiroshi; Yamashita Jun; Yurugi-Kobayashi Takami; Suzuki Yutaka; Kondo Yasushi; Nonoguchi Akane; Sawada Naoki; Yamahara Kenichi; Miyashita Kazutoshi; Park Kwijun; Shibuya Masabumi; Nito Shinji; Nishikawa Shin-Ichi; Nakao Kazuwa
Different differentiation kinetics of vascular progenitor cells in primate and mouse embryonic stem cells.
Circulation 2003;107(16):2085-8.
2003: Matsuoka Yoko; Furuyashiki Tomoyuki; Bito Haruhiko; Ushikubi Fumitaka; Tanaka Yasuhiro; Kobayashi Takuya; Muro Seiji; Satoh Noriko; Kayahara Tetsuro; Higashi Mikito; Mizoguchi Akira; Shichi Hitoshi; Fukuda Yoshihiro; Nakao Kazuwa; Narumiya Shuh
Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4132-7.
2003: Kook Hyun; Itoh Hiroshi; Choi Bong Seok; Sawada Naoki; Doi Kentaro; Hwang Tae Ju; Kim Kyung Keun; Arai Hiroshi; Baik Yung Hong; Nakao Kazuwa
Physiological concentration of atrial natriuretic peptide induces endothelial regeneration in vitro.
American journal of physiology. Heart and circulatory physiology 2003;284(4):H1388-97.
2003: Yurugi-Kobayashi Takami; Itoh Hiroshi; Yamashita Jun; Yamahara Kenichi; Hirai Hideyo; Kobayashi Takuya; Ogawa Minetaro; Nishikawa Satomi; Nishikawa Shin-Ichi; Nakao Kazuwa
Effective contribution of transplanted vascular progenitor cells derived from embryonic stem cells to adult neovascularization in proper differentiation stage.
Blood 2003;101(7):2675-8.
2003: Makino Hisashi; Mukoyama Masashi; Sugawara Akira; Mori Kiyoshi; Suganami Takayoshi; Yahata Kensei; Fujinaga Yuriko; Yokoi Hideki; Tanaka Issei; Nakao Kazuwa
Roles of connective tissue growth factor and prostanoids in early streptozotocin-induced diabetic rat kidney: the effect of aspirin treatment.
Clinical and experimental nephrology 2003;7(1):33-40.
2003: Yamahara Kenichi; Itoh Hiroshi; Chun Tae-Hwa; Ogawa Yoshihiro; Yamashita Jun; Sawada Naoki; Fukunaga Yasutomo; Sone Masakatsu; Yurugi-Kobayashi Takami; Miyashita Kazutoshi; Tsujimoto Hirokazu; Kook Hyun; Feil Robert; Garbers David L; Hofmann Franz; Nakao Kazuwa
Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3404-9.
2003: Masatsugu Ken; Itoh Hiroshi; Chun Tae-Haw; Saito Takatoshi; Yamashita Jun; Doi Kentaro; Inoue Mayumi; Sawada Naoki; Fukunaga Yasutomo; Sakaguchi Satsuki; Sone Masakatsu; Yamahara Kenichi; Yurugi Takami; Nakao Kazuwa
Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress.
Regulatory peptides 2003;111(1-3):13-9.
2003: Miyashita Kazutoshi; Itoh Hiroshi; Sawada Naoki; Fukunaga Yasutomo; Sone Masakatsu; Yamahara Kenichi; Yurugi Takami; Nakao Kazuwa
Adrenomedullin promotes proliferation and migration of cultured endothelial cells.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26 Suppl():S93-8.
2003: Ito Teruhiko; Yoshimura Michihiro; Nakamura Shota; Nakayama Masafumi; Shimasaki Yukio; Harada Eisaku; Mizuno Yuji; Yamamuro Megumi; Harada Masaki; Saito Yoshihiko; Nakao Kazuwa; Kurihara Hiroki; Yasue Hirofumi; Ogawa Hisao
Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes.
Circulation 2003;107(6):807-10.
2003: Kaihara Shinji; Bessho Kazuhisa; Okubo Yasunori; Sonobe Junya; Komatsu Yasato; Miura Masako; Miyatake Shin-Ichi; Nakao Kazuwa; Iizuka Tadahiko
Over expression of bone morphogenetic protein-3b (BMP-3b) using an adenoviral vector promote the osteoblastic differentiation in C2C12 cells and augment the bone formation induced by bone morphogenetic protein-2 (BMP-2) in rats.
Life sciences 2003;72(15):1683-93.
2003: Tanaka Masao; Ozaki Shoichi; Kawabata Daisuke; Kishimura Masaaki; Osakada Fumio; Okubo Mitsuo; Murakami Masao; Nakao Kazuwa; Mimori Tsuneyo
Potential preventive effects of follistatin-related protein/TSC-36 on joint destruction and antagonistic modulation of its autoantibodies in rheumatoid arthritis.
International immunology 2003;15(1):71-7.
2002: Nishimura Takafumi; Nishida Naoshi; Itoh Teruaki; Kuno Masato; Minata Mutsuko; Komeda Toshiki; Fukuda Yoshihiro; Ikai Iwao; Yamaoka Yoshio; Nakao Kazuwa
Comprehensive allelotyping of well-differentiated human hepatocellular carcinoma with semiquantitative determination of chromosomal gain or loss.
Genes, chromosomes & cancer 2002;35(4):329-39.
2002: Fujisawa Takeshi; Komatsu Yasato; Yasoda Akihiro; Miura Masako; Ozasa Ami; Kosugi Shinji; Okamoto Hroomi; Konda Yoshitaka; Kawasaki Kimio; Chiba Tsutomu; Nakao Kazuwa
[In Process Citation]
Clinical calcium 2002;12(11):1576-9.
2002: Moriyama Kenji; Tagami Tetsuya; Akamizu Takashi; Usui Takeshi; Saijo Misa; Kanamoto Naotetsu; Hataya Yuji; Shimatsu Akira; Kuzuya Hideshi; Nakao Kazuwa
Thyroid hormone action is disrupted by bisphenol A as an antagonist.
The Journal of clinical endocrinology and metabolism 2002;87(11):5185-90.
2002: Iwakura Hiroshi; Hosoda Kiminori; Doi Ryuichiro; Komoto Izumi; Nishimura Haruo; Son Choel; Fujikura Junji; Tomita Tsutomu; Takaya Kazuhiko; Ogawa Yoshihiro; Hayashi Tatsuya; Inoue Gen; Akamizu Takashi; Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji; Imamura Masayuki; Nakao Kazuwa
Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I.
The Journal of clinical endocrinology and metabolism 2002;87(11):4885-8.
2002: Yoshimoto Akihiro; Mori Kiyoshi; Sugawara Akira; Mukoyama Masashi; Yahata Kensei; Suganami Takayoshi; Takaya Kazuhiko; Hosoda Hiroshi; Kojima Masayasu; Kangawa Kenji; Nakao Kazuwa
Plasma ghrelin and desacyl ghrelin concentrations in renal failure.
Journal of the American Society of Nephrology : JASN 2002;13(11):2748-52.
2002: Sagawa Norimasa; Yura Shigeo; Itoh Hiroaki; Kakui Kazuyo; Takemura Maki; Nuamah Mercy A; Ogawa Yoshihiro; Masuzaki Hiroaki; Nakao Kazuwa; Fujii Shingo
Possible role of placental leptin in pregnancy: a review.
Endocrine 2002;19(1):65-71.
2002: Kishimoto Ichiro; Saito Yoshihiko; Li Yuhao; Nakao Kazuwa
[Cross-talk between the natriuretic peptide system and the angiotensin system]
Nippon rinsho. Japanese journal of clinical medicine 2002;60(10):1923-8.
2002: Li Yuhao; Kishimoto Ichiro; Saito Yoshihiko; Harada Masaki; Kuwahara Koichiro; Izumi Takehiko; Takahashi Nobuki; Kawakami Rika; Tanimoto Keiji; Nakagawa Yasuaki; Nakanishi Michio; Adachi Yuichiro; Garbers David L; Fukamizu Akiyoshi; Nakao Kazuwa
Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart.
Circulation 2002;106(13):1722-8.
2002: Miyazawa Takashi; Ogawa Yoshihiro; Chusho Hideki; Yasoda Akihiro; Tamura Naohisa; Komatsu Yasato; Pfeifer Alexander; Hofmann Franz; Nakao Kazuwa
Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification.
Endocrinology 2002;143(9):3604-10.
2002: Ariyasu Hiroyuki; Takaya Kazuhiko; Hosoda Hiroshi; Iwakura Hiroshi; Ebihara Ken; Mori Kiyoshi; Ogawa Yoshihiro; Hosoda Kiminori; Akamizu Takashi; Kojima Masayasu; Kangawa Kenji; Nakao Kazuwa
Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin.
Endocrinology 2002;143(9):3341-50.
2002: Ikeda Keiichi; Tojo Katsuyoshi; Oki Yutaka; Nakao Kazuwa
Urocortin has cell-proliferative effects on cardiac non-myocytes.
Life sciences 2002;71(16):1929-38.
2002: Ebihara Ken; Ogawa Yoshihiro; Nakao Kazuwa
[Insulin resistant transgenic mice]
Nippon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 8():79-84.
2002: Hosoda Kiminori; Son Choel; Fujikura Junji; Iwakura Hiroshi; Tomita Tsutomu; Nakao Kazuwa
[Transgenic mouse model of type 2 diabetes mellitus with insulin secretion insufficient]
Nippon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 8():75-8.
2002: Hosoda Kiminori; Son Choel; Fujikura Junji; Iwakura Hiroshi; Tomita Tsutomu; Nakao Kazuwa
[Transgenic mouse model of type 1 diabetes mellitus]
Nippon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 8():70-4.
2002: Yoshimura Michihiro; Nakamura Shota; Ito Teruhiko; Nakayama Masafumi; Harada Eisaku; Mizuno Yuji; Sakamoto Tomohiro; Yamamuro Megumi; Saito Yoshihiko; Nakao Kazuwa; Yasue Hirofumi; Ogawa Hisao
Expression of aldosterone synthase gene in failing human heart: quantitative analysis using modified real-time polymerase chain reaction.
The Journal of clinical endocrinology and metabolism 2002;87(8):3936-40.
2002: Inoue Gen; Koh Makoto; Nakao Kazuwa
[High fat diet and lipotoxicity]
Nippon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():626-31.
2002: Ogawa Yoshihiro; Nakao Kazuwa
[Leptin and leptin receptor]
Nippon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():571-6.
2002: Makino Hisashi; Tanaka Issei; Mukoyama Masashi; Sugawara Akira; Mori Kiyoshi; Muro Seiji; Suganami Takayoshi; Yahata Kensei; Ishibashi Rieko; Ohuchida Shuichi; Maruyama Takayuki; Narumiya Shuh; Nakao Kazuwa
Prevention of diabetic nephropathy in rats by prostaglandin E receptor EP1-selective antagonist.
Journal of the American Society of Nephrology : JASN 2002;13(7):1757-65.
2002: Miyawaki T; Masuzaki H; Ogawa Y; Hosoda K; Nishimura H; Azuma N; Sugawara A; Masuda I; Murata M; Matsuo T; Hayashi T; Inoue G; Yoshimasa Y; Nakao K
Clinical implications of leptin and its potential humoral regulators in long-term low-calorie diet therapy for obese humans.
European journal of clinical nutrition 2002;56(7):593-600.
2002: Yoshimura Michihiro; Mizuno Yuji; Nakayama Masafumi; Sakamoto Tomohiro; Sugiyama Seigo; Kawano Hiroaki; Soejima Hirofumi; Hirai Nobutaka; Saito Yoshihiko; Nakao Kazuwa; Yasue Hirofumi; Ogawa Hisao
B-type natriuretic peptide as a marker of the effects of enalapril in patients with heart failure.
The American journal of medicine 2002;112(9):716-20.
2002: Sawada Naoki; Itoh Hiroshi; Nakao Kazuwa
[Stroke prevention by statins]
Nippon rinsho. Japanese journal of clinical medicine 2002;60(5):993-1001.
2002: Mizuno Yuji; Yasue Hirofumi; Yoshimura Michihiro; Fujii Hiromi; Yamamoto Nobuyasu; Nakayama Masafumi; Harada Eisaku; Sakamoto Tomohiro; Nakamura Shota; Ito Teruhiko; Shimasaki Yukio; Ogawa Hisao; Saito Yoshihiko; Nakao Kazuwa
Effects of perindopril on aldosterone production in the failing human heart.
The American journal of cardiology 2002;89(10):1197-200.
2002: Yokoi Hideki; Mukoyama Masashi; Sugawara Akira; Mori Kiyoshi; Nagae Tetsuya; Makino Hisashi; Suganami Takayoshi; Yahata Kensei; Fujinaga Yuriko; Tanaka Issei; Nakao Kazuwa
Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis.
American journal of physiology. Renal physiology 2002;282(5):F933-42.
2002: Masuzaki Hiroaki; Ogawa Yoshihiro; Aizawa-Abe Megumi; Nakao Kazuwa
Transgenic approach toward leptin biology: the clinical implications of leptin for the treatment of obesity-associated diabetes and obesity-related hypertension.
Endocrine journal 2002;49(2):109-19.
2002: Fujita Y; Murakami M; Ogawa Y; Masuzaki H; Tanaka M; Ozaki S; Nakao K; Mimori T
Leptin inhibits stress-induced apoptosis of T lymphocytes.
Clinical and experimental immunology 2002;128(1):21-6.
2002: Sagawa N; Yura S; Itoh H; Mise H; Kakui K; Korita D; Takemura M; Nuamah M A; Ogawa Y; Masuzaki H; Nakao K; Fujii S
Role of leptin in pregnancy--a review.
Placenta 2002;23 Suppl A():S80-6.
2002: Ohno N; Itoh H; Ikeda T; Ueyama K; Yamahara K; Doi K; Yamashita J; Inoue M; Masatsugu K; Sawada N; Fukunaga Y; Sakaguchi S; Sone M; Yurugi T; Kook H; Komeda M; Nakao K
Accelerated reendothelialization with suppressed thrombogenic property and neointimal hyperplasia of rabbit jugular vein grafts by adenovirus-mediated gene transfer of C-type natriuretic peptide.
Circulation 2002;105(14):1623-6.
2002: Fujikura Junji; Yamato Eiji; Yonemura Shigenobu; Hosoda Kiminori; Masui Shinji; Nakao Kazuwa; Miyazaki Ji Jun-ichi; Niwa Hitoshi
Differentiation of embryonic stem cells is induced by GATA factors.
Genes & development 2002;16(7):784-9.
2002: Yamahara Kenichi; Itoh Hiroshi; Yamamoto Akira; Sasano Hironobu; Masatsugu Ken; Sawada Naoki; Fukunaga Yasutomo; Sakaguchi Satsuki; Sone Masakatsu; Yurugi Takami; Nakao Kazuwa
New diagnostic procedure for primary aldosteronism: adrenal venous sampling under adrenocorticotropic hormone and angiotensin II receptor blocker--application to a case of bilateral multiple adrenal microadenomas.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(2):145-52.
2002: Miura Masako; Tanaka Kiyoshi; Komatsu Yasato; Suda Michio; Yasoda Akihiro; Sakuma Yoko; Ozasa Ami; Nakao Kazuwa
Thyroid hormones promote chondrocyte differentiation in mouse ATDC5 cells and stimulate endochondral ossification in fetal mouse tibias through iodothyronine deiodinases in the growth plate.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(3):443-54.
2002: Miura Masako; Tanaka Kiyoshi; Komatsu Yasato; Suda Michio; Yasoda Akihiro; Sakuma Yoko; Ozasa Ami; Nakao Kazuwa
A novel interaction between thyroid hormones and 1,25(OH)(2)D(3) in osteoclast formation.
Biochemical and biophysical research communications 2002;291(4):987-94.
2002: Shintani Mitsuyo; Ogawa Yoshihiro; Nakao Kazuwa
[Obesity induced by abnormality in leptin receptor and melanocortin-4 receptor]
Nippon rinsho. Japanese journal of clinical medicine 2002;60(2):404-9.
2002: Ogawa Emiko; Saito Yoshihiko; Kuwahara Koichiro; Harada Masaki; Miyamoto Yoshihiro; Hamanaka Ichiro; Kajiyama Noboru; Takahashi Nobuki; Izumi Takehiko; Kawakami Rika; Kishimoto Ichiro; Naruse Yoshihisa; Mori Nozomu; Nakao Kazuwa
Fibronectin signaling stimulates BNP gene transcription by inhibiting neuron-restrictive silencer element-dependent repression.
Cardiovascular research 2002;53(2):451-9.
2002: Kobayashi Hiromasa; Shimodahira Makiko; Iwakura Toshio; Ishihara Takashi; Kurahachi Hiroyuki; Hino Megumu; Ikekubo Katsuji; Ogawa Yoshihiro; Nakao Kazuwa
[In Process Citation]
Clinical calcium 2002;12(1):124-7.
2002: Goto Masahisa; Mukoyama Masashi; Sugawara Akira; Suganami Takayoshi; Kasahara Masato; Yahata Kensei; Makino Hisashi; Suga Shinichi; Tanaka Issei; Nakao Kazuwa
Expression and role of angiotensin II type 2 receptor in the kidney and mesangial cells of spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(1):125-33.
2002: Akamizu T; Ozaki S; Hiratani H; Uesugi H; Sobajima J; Hataya Y; Kanamoto N; Saijo M; Hattori Y; Moriyama K; Ohmori K; Nakao K
Drug-induced neutropenia associated with anti-neutrophil cytoplasmic antibodies (ANCA): possible involvement of complement in granulocyte cytotoxicity.
Clinical and experimental immunology 2002;127(1):92-8.
2002: Ogawa Yoshihiro; Masuzaki Hiroaki; Ebihara Ken; Shintani Mitsuyo; Aizawa-Abe Megumi; Miyanaga Fumiko; Nakao Kazuwa
Pathophysiogical role of leptin in lifestyle-related diseases. Studies with transgenic skinny mice overexpressing leptin.
Journal of diabetes and its complications 2002;16(1):119-22.
2002: Kobayashi Hiromasa; Hino Megumu; Shimodahira Makiko; Iwakura Toshio; Ishihara Takashi; Ikekubo Katsuji; Ogawa Yoshihiro; Nakao Kazuwa; Kurahachi Hiroyuki
Missense mutation of TRPS1 in a family of tricho-rhino-phalangeal syndrome type III.
American journal of medical genetics 2002;107(1):26-9.
2002: Kobayashi Hiromasa; Ogawa Yoshihiro; Shintani Mitsuyo; Ebihara Ken; Shimodahira Makiko; Iwakura Toshio; Hino Megumu; Ishihara Takashi; Ikekubo Katsuji; Kurahachi Hiroyuki; Nakao Kazuwa
A Novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity.
Diabetes 2002;51(1):243-6.
2002: Komatsu Yasato; Chusho Hideki; Tamura Naohisa; Yasoda Akihiro; Miyazawa Takashi; Suda Michio; Miura Masako; Ogawa Yoshihiro; Nakao Kazuwa
Significance of C-type natriuretic peptide (CNP) in endochondral ossification: analysis of CNP knockout mice.
Journal of bone and mineral metabolism 2002;20(6):331-6.
2002: Suda Michio; Tanaka Kiyoshi; Yasoda Akihiro; Komatsu Yasato; Chusho Hideki; Miura Masako; Tamura Naohisa; Ogawa Yoshihiro; Nakao Kazuwa
C-type natriuretic peptide/guanylate cyclase B system in ATDC5 cells, a chondrogenic cell line.
Journal of bone and mineral metabolism 2002;20(3):136-41.
2002: Nishida Naoshi; Fukuda Yoshihiro; Komeda Toshiki; Ito Teruaki; Nishimura Takafumi; Minata Mutsuko; Kuno Masato; Katsuma Hirokazu; Ikai Iwao; Yamaoka Yoshio; Nakao Kazuwa
Prognostic impact of multiple allelic losses on metastatic recurrence in hepatocellular carcinoma after curative resection.
Oncology 2002;62(2):141-8.
2001: Sawada N; Itoh H; Nakao K
[Novel actions of HMG-CoA reductase inhibitors(statins)--vascular and cerebral protection through inhibition of small GTPase Rho]
Nippon rinsho. Japanese journal of clinical medicine 2001;59(12):2470-5.
2001: Suganami T; Mukoyama M; Sugawara A; Mori K; Nagae T; Kasahara M; Yahata K; Makino H; Fujinaga Y; Ogawa Y; Tanaka I; Nakao K
Overexpression of brain natriuretic peptide in mice ameliorates immune-mediated renal injury.
Journal of the American Society of Nephrology : JASN 2001;12(12):2652-63.
2001: Mukoyama M; Sugawara A; Nagae T; Mori K; Murabe H; Itoh H; Tanaka I; Nakao K
Role of adrenomedullin and its receptor system in renal pathophysiology.
Peptides 2001;22(11):1925-31.
2001: Hidaka S; Ogawa Y; Nakao K
[Potential molecular targets for anti-obesity drugs--after the discovery of leptin]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2001;118(5):309-14.
2001: Kanamoto N; Akamizu T; Hosoda H; Hataya Y; Ariyasu H; Takaya K; Hosoda K; Saijo M; Moriyama K; Shimatsu A; Kojima M; Kangawa K; Nakao K
Substantial production of ghrelin by a human medullary thyroid carcinoma cell line.
The Journal of clinical endocrinology and metabolism 2001;86(10):4984-90.
2001: Ariyasu H; Takaya K; Tagami T; Ogawa Y; Hosoda K; Akamizu T; Suda M; Koh T; Natsui K; Toyooka S; Shirakami G; Usui T; Shimatsu A; Doi K; Hosoda H; Kojima M; Kangawa K; Nakao K
Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans.
The Journal of clinical endocrinology and metabolism 2001;86(10):4753-8.
2001: Yokoi H; Sugawara A; Mukoyama M; Mori K; Makino H; Suganami T; Nagae T; Yahata K; Fujinaga Y; Tanaka I; Nakao K
Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;38(4 Suppl 1):S134-8.
2001: Shintani M; Nishimura H; Yonemitsu S; Ogawa Y; Hayashi T; Hosoda K; Inoue G; Nakao K
Troglitazone not only increases GLUT4 but also induces its translocation in rat adipocytes.
Diabetes 2001;50(10):2296-300.
2001: Son C; Hosoda K; Matsuda J; Fujikura J; Yonemitsu S; Iwakura H; Masuzaki H; Ogawa Y; Hayashi T; Itoh H; Nishimura H; Inoue G; Yoshimasa Y; Yamori Y; Nakao K
Up-regulation of uncoupling protein 3 gene expression by fatty acids and agonists for PPARs in L6 myotubes.
Endocrinology 2001;142(10):4189-94.
2001: Tsuzuki T; Egashira A; Igarashi H; Iwakuma T; Nakatsuru Y; Tominaga Y; Kawate H; Nakao K; Nakamura K; Ide F; Kura S; Nakabeppu Y; Katsuki M; Ishikawa T; Sekiguchi M
Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11456-61.
2001: Hataya Y; Akamizu T; Takaya K; Kanamoto N; Ariyasu H; Saijo M; Moriyama K; Shimatsu A; Kojima M; Kangawa K; Nakao K
A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans.
The Journal of clinical endocrinology and metabolism 2001;86(9):4552.
2001: Saito T; Itoh H; Chun T H; Fukunaga Y; Yamashita J; Doi K; Tanaka T; Inoue M; Masatsugu K; Sawada N; Sakaguchi S; Arai H; Mukoyama M; Tojo K; Hosoya T; Nakao K
Coordinate regulation of endothelin and adrenomedullin secretion by oxidative stress in endothelial cells.
American journal of physiology. Heart and circulatory physiology 2001;281(3):H1364-71.
2001: Hattori Y; Akamizu T; Saijo M; Kanamoto N; Moriyama K; Ito N; Nakao K
Characterization of the secretable ectodomain of thyrotropin receptor produced by the recombinant baculovirus system.
Molecular and cellular endocrinology 2001;182(2):165-74.
2001: Fukunaga Y; Itoh H; Doi K; Tanaka T; Yamashita J; Chun T H; Inoue M; Masatsugu K; Sawada N; Saito T; Hosoda K; Kook H; Ueda M; Nakao K
Thiazolidinediones, peroxisome proliferator-activated receptor gamma agonists, regulate endothelial cell growth and secretion of vasoactive peptides.
Atherosclerosis 2001;158(1):113-9.
2001: Izumi T; Saito Y; Kishimoto I; Harada M; Kuwahara K; Hamanaka I; Takahashi N; Kawakami R; Li Y; Takemura G; Fujiwara H; Garbers D L; Mochizuki S; Nakao K
Blockade of the natriuretic peptide receptor guanylyl cyclase-A inhibits NF-kappaB activation and alleviates myocardial ischemia/reperfusion injury.
The Journal of clinical investigation 2001;108(2):203-13.
2001: Harada E; Yoshimura M; Yasue H; Nakagawa O; Nakagawa M; Harada M; Mizuno Y; Nakayama M; Shimasaki Y; Ito T; Nakamura S; Kuwahara K; Saito Y; Nakao K; Ogawa H
Aldosterone induces angiotensin-converting-enzyme gene expression in cultured neonatal rat cardiocytes.
Circulation 2001;104(2):137-9.
2001: Inoue G; Sakurai T; Tanaka K; Akamizu T; Masuzaki H; Hosoda K; Hayashi T; Yoshimasa Y; Nakao K
Simultaneous onset of type 1 diabetes mellitus and painless thyroiditis following acute pancreatitis.
Internal medicine (Tokyo, Japan) 2001;40(6):515-8.
2001: Suganami T; Tanaka I; Mukoyama M; Kotani M; Muro S; Mori K; Goto M; Ishibashi R; Kasahara M; Yahata K; Makino H; Sugawara A; Nakao K
Altered growth response to prostaglandin E2 and its receptor signaling in mesangial cells from stroke-prone spontaneously hypertensive rats.
Journal of hypertension 2001;19(6):1095-103.
2001: Doi K; Ikeda T; Itoh H; Ueyama K; Hosoda K; Ogawa Y; Yamashita J; Chun T H; Inoue M; Masatsugu K; Sawada N; Fukunaga Y; Saito T; Sone M; Yamahara K; Kook H; Komeda M; Ueda M; Nakao K
C-type natriuretic peptide induces redifferentiation of vascular smooth muscle cells with accelerated reendothelialization.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(6):930-6.
2001: Ebihara K; Ogawa Y; Masuzaki H; Shintani M; Miyanaga F; Aizawa-Abe M; Hayashi T; Hosoda K; Inoue G; Yoshimasa Y; Gavrilova O; Reitman M L; Nakao K
Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes.
Diabetes 2001;50(6):1440-8.
2001: Yonemitsu S; Nishimura H; Shintani M; Inoue R; Yamamoto Y; Masuzaki H; Ogawa Y; Hosoda K; Inoue G; Hayashi T; Nakao K
Troglitazone induces GLUT4 translocation in L6 myotubes.
Diabetes 2001;50(5):1093-101.
2001: Okazaki T; Ozaki S; Nagaoka T; Kozuki M; Sumita S; Tanaka M; Osakada F; Kishimura M; Kakutani T; Nakao K
Antigen-specific T(h)1 cells as direct effectors of Propionibacterium acnes-primed lipopolysaccharide-induced hepatic injury.
International immunology 2001;13(5):607-13.
2001: Minata M; Nishida N; Komeda T; Azechi H; Katsuma H; Nishimura T; Kuno M; Ito T; Yamamoto Y; Ikai I; Yamaoka Y; Fukuda Y; Nakao K
Postoperative detection of alpha-fetoprotein mRNA in blood as a predictor for metastatic recurrence of hepatocellular carcinoma.
Journal of gastroenterology and hepatology 2001;16(4):445-51.
2001: Hamanaka I; Saito Y; Yasukawa H; Kishimoto I; Kuwahara K; Miyamoto Y; Harada M; Ogawa E; Kajiyama N; Takahashi N; Izumi T; Kawakami R; Masuda I; Yoshimura A; Nakao K
Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo.
Circulation research 2001;88(7):727-32.
2001: Inoue M; Itoh H; Tanaka T; Chun T H; Doi K; Fukunaga Y; Sawada N; Yamshita J; Masatsugu K; Saito T; Sakaguchi S; Sone M; Yamahara Ki; Yurugi T; Nakao K
Oxidized LDL regulates vascular endothelial growth factor expression in human macrophages and endothelial cells through activation of peroxisome proliferator-activated receptor-gamma.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(4):560-6.
2001: Nakagawa M; Tanaka I; Mukoyama M; Suga S; Ogawa Y; Tamura N; Ishibashi R; Goto M; Nakagawa O; Sugawara A; Nakao K
Monoclonal antibody against brain natriuretic peptide and characterization of brain natriuretic peptide-transgenic mice.
Journal of hypertension 2001;19(3):475-83.
2001: Hidaka S; Ogawa Y; Ebihara K; Shintani M; Abe M; Miyanaga F; Nakao K
[Pathology and significance of leptin resistance in obesity]
Nippon rinsho. Japanese journal of clinical medicine 2001;59(3):472-80.
2001: Chusho H; Tamura N; Ogawa Y; Yasoda A; Suda M; Miyazawa T; Nakamura K; Nakao K; Kurihara T; Komatsu Y; Itoh H; Tanaka K; Saito Y; Katsuki M; Nakao K
Dwarfism and early death in mice lacking C-type natriuretic peptide.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4016-21.
2001: Chusho H; Tamura N; Ogawa Y; Yasoda A; Suda M; Miyazawa T; Nakamura K; Nakao K; Kurihara T; Komatsu Y; Itoh H; Tanaka K; Saito Y; Katsuki M; Nakao K
Dwarfism and early death in mice lacking C-type natriuretic peptide.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4016-21.
2001: Itoh H; Nakao K
[Significance of PPAR gamma (peroxisome proliferator-activated receptor gamma) in atherosclerosis]
Nippon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 2():602-16.
2001: Shintani M; Ogawa Y; Ebihara K; Aizawa-Abe M; Miyanaga F; Takaya K; Hayashi T; Inoue G; Hosoda K; Kojima M; Kangawa K; Nakao K
Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway.
Diabetes 2001;50(2):227-32.
2001: Kishi N; Tang Z; Maeda Y; Hirai A; Mo R; Ito M; Suzuki S; Nakao K; Kinoshita T; Kadesch T; Hui C; Artavanis-Tsakonas S; Okano H; Matsuno K
Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2001;19(1):21-35.
2001: Matsuoka N; Ogawa Y; Masuzaki H; Ebihara K; Aizawa-Abe M; Satoh N; Ishikawa E; Fujisawa Y; Kosaki A; Yamada K; Kuzuya H; Nakao K
Decreased triglyceride-rich lipoproteins in transgenic skinny mice overexpressing leptin.
American journal of physiology. Endocrinology and metabolism 2001;280(2):E334-9.
2001: Sawada N; Itoh H; Yamashita J; Doi K; Inoue M; Masatsugu K; Fukunaga Y; Sakaguchi S; Sone M; Yamahara K; Yurugi T; Nakao K
cGMP-dependent protein kinase phosphorylates and inactivates RhoA.
Biochemical and biophysical research communications 2001;280(3):798-805.
2001: Azechi H; Nishida N; Fukuda Y; Nishimura T; Minata M; Katsuma H; Kuno M; Ito T; Komeda T; Kita R; Takahashi R; Nakao K
Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas.
Oncology 2001;60(4):346-54.
2000: Akamizu T; Kaneko H; Noguchi N; Kashii S; Nakao K
Moisture chamber for management of corneal ulcer due to Graves' ophthalmopathy.
Thyroid : official journal of the American Thyroid Association 2000;10(12):1123-4.
2000: Ma W; Ozaki S; Sobajima J; Uesugi H; Murakami M; Tanaka M; Kozuki M; Hashimoto H; Fujita Y; Kawabata D; Osakada F; Shirakawa H; Yoshida M; Hayami M; Nakao K
Detection of anti-neutrophil cytoplasmic antibodies in MRL/Mp-lpr/lpr mice and analysis of their target antigens.
Autoimmunity 2000;32(4):281-91.
2000: Takaya K; Ariyasu H; Kanamoto N; Iwakura H; Yoshimoto A; Harada M; Mori K; Komatsu Y; Usui T; Shimatsu A; Ogawa Y; Hosoda K; Akamizu T; Kojima M; Kangawa K; Nakao K
Ghrelin strongly stimulates growth hormone release in humans.
The Journal of clinical endocrinology and metabolism 2000;85(12):4908-11.
2000: Mori K; Yoshimoto A; Takaya K; Hosoda K; Ariyasu H; Yahata K; Mukoyama M; Sugawara A; Hosoda H; Kojima M; Kangawa K; Nakao K
Kidney produces a novel acylated peptide, ghrelin.
FEBS letters 2000;486(3):213-6.
2000: Fukui Y; Oono T; Cabaniols J P; Nakao K; Hirokawa K; Inayoshi A; Sanui T; Kanellopoulos J; Iwata E; Noda M; Katsuki M; Kourilsky P; Sasazuki T
Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13760-5.
2000: Sakuma Y; Tanaka K; Suda M; Komatsu Y; Yasoda A; Miura M; Ozasa A; Narumiya S; Sugimoto Y; Ichikawa A; Ushikubi F; Nakao K
Impaired bone resorption by lipopolysaccharide in vivo in mice deficient in the prostaglandin E receptor EP4 subtype.
Infection and immunity 2000;68(12):6819-25.
2000: Ikeda K; Tojo K; Tokudome G; Hosoya T; Harada M; Nakao K
The effects of sarpogrelate on cardiomyocyte hypertrophy.
Life sciences 2000;67(24):2991-6.
2000: Kajiyama N; Saito Y; Miyamoto Y; Yoshimura M; Nakayama M; Harada M; Kuwahara K; Kishimoto I; Yasue H; Nakao K
Lack of association between T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 2000;23(6):561-5.
2000: Mori K; Yahata K; Mukoyama M; Suganami T; Makino H; Nagae T; Masuzaki H; Ogawa Y; Sugawara A; Nabeshima Y; Nakao K
Disruption of klotho gene causes an abnormal energy homeostasis in mice.
Biochemical and biophysical research communications 2000;278(3):665-70.
2000: Kotani M; Tanaka I; Ogawa Y; Suganami T; Matsumoto T; Muro S; Yamamoto Y; Sugawara A; Yoshimasa Y; Sagawa N; Narumiya S; Nakao K
Multiple signal transduction pathways through two prostaglandin E receptor EP3 subtype isoforms expressed in human uterus.
The Journal of clinical endocrinology and metabolism 2000;85(11):4315-22.
2000: Yamashita J; Itoh H; Hirashima M; Ogawa M; Nishikawa S; Yurugi T; Naito M; Nakao K; Nishikawa S
Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors.
Nature 2000;408(6808):92-6.
2000: Miyamoto Y; Saito Y; Nakayama M; Shimasaki Y; Yoshimura T; Yoshimura M; Harada M; Kajiyama N; Kishimoto I; Kuwahara K; Hino J; Ogawa E; Hamanaka I; Kamitani S; Takahashi N; Kawakami R; Kangawa K; Yasue H; Nakao K
Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T-->C mutation associated with coronary spastic angina.
Human molecular genetics 2000;9(18):2629-37.
2000: Mizuno Y; Yoshimura M; Harada E; Nakayama M; Sakamoto T; Shimasaki Y; Ogawa H; Kugiyama K; Saito Y; Nakao K; Yasue H
Plasma levels of A- and B-type natriuretic peptides in patients with hypertrophic cardiomyopathy or idiopathic dilated cardiomyopathy.
The American journal of cardiology 2000;86(9):1036-40, A11.
2000: Akamizu T; Sale M M; Rich S S; Hiratani H; Noh J Y; Kanamoto N; Saijo M; Miyamoto Y; Saito Y; Nakao K; Bowden D W
Association of autoimmune thyroid disease with microsatellite markers for the thyrotropin receptor gene and CTLA-4 in Japanese patients.
Thyroid : official journal of the American Thyroid Association 2000;10(10):851-8.
2000: Chusho H; Ogawa Y; Tamura N; Suda M; Yasoda A; Miyazawa T; Kishimoto I; Komatsu Y; Itoh H; Tanaka K; Saito Y; Garbers D L; Nakao K
Genetic models reveal that brain natriuretic peptide can signal through different tissue-specific receptor-mediated pathways.
Endocrinology 2000;141(10):3807-13.
2000: Yoshimura M; Mizuno Y; Harada E; Nakayama M; Shimasaki Y; Ito T; Nakamura S; Soejima H; Miyamoto S; Takazoe K; Ogawa H; Kugiyama K; Saito Y; Nakao K; Yasue H
Interaction on metabolic clearance between A-type and B-type natriuretic peptides in patients with heart failure.
Metabolism: clinical and experimental 2000;49(9):1228-33.
2000: Ikeda K; Tojo K; Tokudome G; Akashi T; Hosoya T; Harada M; Nakagawa O; Nakao K
Possible involvement of endothelin-1 in cardioprotective effects of benidipine.
Hypertension research : official journal of the Japanese Society of Hypertension 2000;23(5):491-6.
2000: Fukunaga Y; Itoh H; Hosoda K; Doi K; Matsuda J; Son C; Yamashita J; Chun T H; Tanaka T; Inoue M; Masatsugu K; Saito T; Sawada N; Nakao K
Altered gene expression of uncoupling protein-2 and -3 in stroke-prone spontaneously hypertensive rats.
Journal of hypertension 2000;18(9):1233-8.
2000: Hirai N; Kawano H; Hirashima O; Motoyama T; Moriyama Y; Sakamoto T; Kugiyama K; Ogawa H; Nakao K; Yasue H
Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C.
American journal of physiology. Heart and circulatory physiology 2000;279(3):H1172-8.
2000: Nakayama M; Yasue H; Yoshimura M; Shimasaki Y; Ogawa H; Kugiyama K; Mizuno Y; Harada E; Nakamura S; Ito T; Saito Y; Miyamoto Y; Ogawa Y; Nakao K
T(-786)--> C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis.
The American journal of cardiology 2000;86(6):628-34.
2000: Yoshimura M; Yasue H; Nakayama M; Shimasaki Y; Ogawa H; Kugiyama K; Saito Y; Miyamoto Y; Ogawa Y; Kaneshige T; Hiramatsu H; Yoshioka T; Kamitani S; Teraoka H; Nakao K
Genetic risk factors for coronary artery spasm: significance of endothelial nitric oxide synthase gene T-786-->C and missense Glu298Asp variants.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2000;48(5):367-74.
2000: Kasahara M; Mukoyama M; Sugawara A; Makino H; Suganami T; Ogawa Y; Nakagawa M; Yahata K; Goto M; Ishibashi R; Tamura N; Tanaka I; Nakao K
Ameliorated glomerular injury in mice overexpressing brain natriuretic peptide with renal ablation.
Journal of the American Society of Nephrology : JASN 2000;11(9):1691-701.
2000: Kobayashi H; Usui T; Fukata J; Yoshimasa T; Oki Y; Nakao K
Mutation analysis of Gsalpha, adrenocorticotropin receptor and p53 genes in Japanese patients with adrenocortical neoplasms: including a case of Gsalpha mutation.
Endocrine journal 2000;47(4):461-6.
2000: Muro S; Tanaka I; Usui T; Kotani M; Koide S; Mukoyama M; Fukata J; Itoh H; Narumiya S; Kawata M; Nakao K
Expression of prostaglandin E receptor EP4 subtype in rat adrenal zona glomerulosa: involvement in aldosterone release.
Endocrine journal 2000;47(4):429-36.
2000: Kuwahara K; Saito Y; Kishimoto I; Miyamoto Y; Harada M; Ogawa E; Hamanaka I; Kajiyama N; Takahashi N; Izumi T; Kawakami R; Nakao K
Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes.
Journal of molecular and cellular cardiology 2000;32(8):1385-94.
2000: Ogawa Y; Nakao K
[Transgenic skinny mice overexpressing leptin]
Seikagaku. The Journal of Japanese Biochemical Society 2000;72(7):554-8.
2000: Hamanaka I; Saito Y; Nishikimi T; Magaribuchi T; Kamitani S; Kuwahara K; Ishikawa M; Miyamoto Y; Harada M; Ogawa E; Kajiyama N; Takahashi N; Izumi T; Shirakami G; Mori K; Inobe Y; Kishimoto I; Masuda I; Fukuda K; Nakao K
Effects of cardiotrophin-1 on hemodynamics and endocrine function of the heart.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H388-96.
2000: Tanaka M; Kishimura M; Ozaki S; Osakada F; Hashimoto H; Okubo M; Murakami M; Nakao K
Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis.
The Journal of clinical investigation 2000;106(1):137-44.
2000: Nakao K; Itoh H; Takaya K
Current topics in pheochromocytoma.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2000;54 Suppl 1():124s-128s.
2000: Akamizu T; Nakao K
Air in the thyroid.
Thyroid : official journal of the American Thyroid Association 2000;10(6):519-20.
2000: Akamizu T; Kohn L D; Hiratani H; Saijo M; Tahara K; Nakao K
Hashimoto's thyroiditis with heterogeneous antithyrotropin receptor antibodies: unique epitopes may contribute to the regulation of thyroid function by the antibodies.
The Journal of clinical endocrinology and metabolism 2000;85(6):2116-21.
2000: Moriyama Y; Yasue H; Yoshimura M; Mizuno Y; Nishiyama K; Tsunoda R; Kawano H; Kugiyama K; Ogawa H; Saito Y; Nakao K
The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity.
The Journal of clinical endocrinology and metabolism 2000;85(5):1834-40.
2000: Chun T H; Itoh H; Saito T; Yamahara K; Doi K; Mori Y; Ogawa Y; Yamashita J; Tanaka T; Inoue M; Masatsugu K; Sawada N; Fukunaga Y; Nakao K
Oxidative stress augments secretion of endothelium-derived relaxing peptides, C-type natriuretic peptide and adrenomedullin.
Journal of hypertension 2000;18(5):575-80.
2000: Aizawa-Abe M; Ogawa Y; Masuzaki H; Ebihara K; Satoh N; Iwai H; Matsuoka N; Hayashi T; Hosoda K; Inoue G; Yoshimasa Y; Nakao K
Pathophysiological role of leptin in obesity-related hypertension.
The Journal of clinical investigation 2000;105(9):1243-52.
2000: Sawada N; Itoh H; Ueyama K; Yamashita J; Doi K; Chun T H; Inoue M; Masatsugu K; Saito T; Fukunaga Y; Sakaguchi S; Arai H; Ohno N; Komeda M; Nakao K
Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries.
Circulation 2000;101(17):2030-3.
2000: Ogawa E; Saito Y; Harada M; Kamitani S; Kuwahara K; Miyamoto Y; Ishikawa M; Hamanaka I; Kajiyama N; Takahashi N; Nakagawa O; Masuda I; Kishimoto I; Nakao K
Outside-in signalling of fibronectin stimulates cardiomyocyte hypertrophy in cultured neonatal rat ventricular myocytes.
Journal of molecular and cellular cardiology 2000;32(5):765-76.
2000: Masuzaki H; Ogawa Y; Nakao K
[The role of leptin in human obesity and related diseases--recent progress and future directions]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(6 Suppl):1125-32.
2000: Tamura N; Ogawa Y; Chusho H; Nakamura K; Nakao K; Suda M; Kasahara M; Hashimoto R; Katsuura G; Mukoyama M; Itoh H; Saito Y; Tanaka I; Otani H; Katsuki M
Cardiac fibrosis in mice lacking brain natriuretic peptide.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4239-44.
2000: Nagae T; Mukoyama M; Sugawara A; Mori K; Yahata K; Kasahara M; Suganami T; Makino H; Fujinaga Y; Yoshioka T; Tanaka I; Nakao K
Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy.
Biochemical and biophysical research communications 2000;270(1):89-93.
2000: Yoshimura M; Nakayama M; Shimasaki Y; Ogawa H; Kugiyama K; Nakamura S; Ito T; Mizuno Y; Harada E; Yasue H; Miyamoto Y; Saito Y; Nakao K
A T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and coronary arterial vasomotility.
The American journal of cardiology 2000;85(6):710-4.
2000: Usui T; Nakamura Y; Mizuta H; Murabe H; Muro S; Suda M; Tanaka K; Tanaka I; Shimatsu A; Nakao K
Functional significance of prop-1 gene expression in pituitary adenomas.
Endocrine journal 2000;47 Suppl():S85-9.
2000: Yamamoto Y; Yoshimasa Y; Koh M; Suga J; Masuzaki H; Ogawa Y; Hosoda K; Nishimura H; Watanabe Y; Inoue G; Nakao K
Constitutively active mitogen-activated protein kinase kinase increases GLUT1 expression and recruits both GLUT1 and GLUT4 at the cell surface in 3T3-L1 adipocytes.
Diabetes 2000;49(3):332-9.
2000: Yura S; Ogawa Y; Sagawa N; Masuzaki H; Itoh H; Ebihara K; Aizawa-Abe M; Fujii S; Nakao K
Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin.
The Journal of clinical investigation 2000;105(6):749-55.
2000: Shintani M; Nishimura H; Yonemitsu S; Masuzaki H; Ogawa Y; Hosoda K; Inoue G; Yoshimasa Y; Nakao K
Downregulation of leptin by free fatty acids in rat adipocytes: effects of triacsin C, palmitate, and 2-bromopalmitate.
Metabolism: clinical and experimental 2000;49(3):326-30.
2000: Suda M; Tanaka K; Sakuma Y; Yasoda A; Ozasa A; Fukata J; Tanaka I; Narumiya S; Nakao K
Prostaglandin E(2) (PGE(2)) induces the c-fos and c-jun expressions via the EP(1) subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells.
Calcified tissue international 2000;66(3):217-23.
2000: Shintani M; Ogawa Y; Nakao K
[Insulin resistance, role of leptin and leptin receptor]
Nippon rinsho. Japanese journal of clinical medicine 2000;58(2):327-32.
2000: Sakuma Y; Tanaka K; Suda M; Yasoda A; Natsui K; Tanaka I; Ushikubi F; Narumiya S; Segi E; Sugimoto Y; Ichikawa A; Nakao K
Crucial involvement of the EP4 subtype of prostaglandin E receptor in osteoclast formation by proinflammatory cytokines and lipopolysaccharide.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(2):218-27.
2000: Aizawa-Abe M; Ogawa Y; Masuzaki H; Nakao K
[Ob gene]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():551-5.
2000: Mukoyama M; Sugawara A; Itoh H; Nakao K
[Natriuretic peptide family]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():466-71.
2000: Itoh H; Nakao K
[Significance of PPAR gamma(peroxisome proliferator-activated receptor gamma) in hypertension and its vascular complications]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():214-24.
2000: Itoh H; Nakao K
[VEGF and vasculoangiogenesis/vascular remodeling]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():200-5.
2000: Masuzaki H; Ogawa Y; Ebihara K; Nakao K
[Molecular medicine in leptin biology]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():157-62.
2000: Kishimoto I; Saito Y; Nakao K
[The natriuretic peptide system]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():139-47.
2000: Yahata K; Mori K; Arai H; Koide S; Ogawa Y; Mukoyama M; Sugawara A; Ozaki S; Tanaka I; Nabeshima Y; Nakao K
Molecular cloning and expression of a novel klotho-related protein.
Journal of molecular medicine (Berlin, Germany) 2000;78(7):389-94.
1999: Shintani M; Nishimura H; Akamizu T; Yonemitsu S; Masuzaki H; Ogawa Y; Hosoda K; Inoue G; Yoshimasa Y; Nakao K
Thyrotropin decreases leptin production in rat adipocytes.
Metabolism: clinical and experimental 1999;48(12):1570-4.
1999: Suda M; Komatsu Y; Tanaka K; Yasoda A; Sakuma Y; Tamura N; Ogawa Y; Nakao K
C-Type natriuretic peptide/guanylate cyclase B system in rat osteogenic ROB-C26 cells and its down-regulation by dexamethazone.
Calcified tissue international 1999;65(6):472-8.
1999: Harada E; Nakagawa O; Yoshimura M; Harada M; Nakagawa M; Mizuno Y; Shimasaki Y; Nakayama M; Yasue H; Kuwahara K; Saito Y; Nakao K
Effect of interleukin-1 beta on cardiac hypertrophy and production of natriuretic peptides in rat cardiocyte culture.
Journal of molecular and cellular cardiology 1999;31(11):1997-2006.
1999: Yahata K; Tanaka I; Kotani M; Mukoyama M; Ogawa Y; Goto M; Nakagawa M; Sugawara A; Tanaka K; Shimatsu A; Nakao K
Identification of a novel R642C mutation in Na/Cl cotransporter with Gitelman's syndrome.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1999;34(5):845-53.
1999: Moriyama K; Akamizu T; Umemoto M; Miura M; Saijo M; Taniguchi K; Nakao K
A case of Hashimoto's thyroiditis with markedly elevated serum thyroglobulin and evidence of its influence on the measurement of anti-thyroglobulin antibody by highly sensitive assays.
Endocrine journal 1999;46(5):687-93.
1999: Ebihara K; Ogawa Y; Katsuura G; Numata Y; Masuzaki H; Satoh N; Tamaki M; Yoshioka T; Hayase M; Matsuoka N; Aizawa-Abe M; Yoshimasa Y; Nakao K
Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action.
Diabetes 1999;48(10):2028-33.
1999: Itoh H; Nakao K
Vascular stress response and endothelial vasoactive factors for vascular remodelling.
Diabetes research and clinical practice 1999;45(2-3):83-8.
1999: Ogawa Y; Masuzaki H; Hosoda K; Aizawa-Abe M; Suga J; Suda M; Ebihara K; Iwai H; Matsuoka N; Satoh N; Odaka H; Kasuga H; Fujisawa Y; Inoue G; Nishimura H; Yoshimasa Y; Nakao K
Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.
Diabetes 1999;48(9):1822-9.
1999: Satoh N; Ogawa Y; Katsuura G; Numata Y; Tsuji T; Hayase M; Ebihara K; Masuzaki H; Hosoda K; Yoshimasa Y; Nakao K
Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion.
Diabetes 1999;48(9):1787-93.
1999: Sasaki Y; Takahashi T; Miyazaki H; Matsumoto A; Kato T; Nakamura K; Iho S; Okuno Y; Nakao K
Production of thrombopoietin by human carcinomas and its novel isoforms.
Blood 1999;94(6):1952-60.
1999: Kuwahara K; Saito Y; Harada M; Ishikawa M; Ogawa E; Miyamoto Y; Hamanaka I; Kamitani S; Kajiyama N; Takahashi N; Nakagawa O; Masuda I; Nakao K
Involvement of cardiotrophin-1 in cardiac myocyte-nonmyocyte interactions during hypertrophy of rat cardiac myocytes in vitro.
Circulation 1999;100(10):1116-24.
1999: Chin K; Shimizu K; Nakamura T; Narai N; Masuzaki H; Ogawa Y; Mishima M; Nakamura T; Nakao K; Ohi M
Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy.
Circulation 1999;100(7):706-12.
1999: Ishibashi R; Tanaka I; Kotani M; Muro S; Goto M; Sugawara A; Mukoyama M; Sugimoto Y; Ichikawa A; Narumiya S; Nakao K
Roles of prostaglandin E receptors in mesangial cells under high-glucose conditions.
Kidney international 1999;56(2):589-600.
1999: Masuzaki H; Ogawa Y; Aizawa-Abe M; Hosoda K; Suga J; Ebihara K; Satoh N; Iwai H; Inoue G; Nishimura H; Yoshimasa Y; Nakao K
Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin for the treatment of obesity-associated diabetes.
Diabetes 1999;48(8):1615-22.
1999: Hosoda K; Matsuda J; Itoh H; Son C; Doi K; Tanaka T; Fukunaga Y; Yamori Y; Nakao K
New members of uncoupling protein family implicated in energy metabolism.
Clinical and experimental pharmacology & physiology 1999;26(7):561-2.
1999: Itoh H; Doi K; Tanaka T; Fukunaga Y; Hosoda K; Inoue G; Nishimura H; Yoshimasa Y; Yamori Y; Nakao K
Hypertension and insulin resistance: role of peroxisome proliferator-activated receptor gamma.
Clinical and experimental pharmacology & physiology 1999;26(7):558-60.
1999: Ito Y; Matsuura N; Sakon M; Miyoshi E; Noda K; Takeda T; Umeshita K; Nagano H; Nakamori S; Dono K; Tsujimoto M; Nakahara M; Nakao K; Taniguchi N; Monden M
Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence.
Hepatology (Baltimore, Md.) 1999;30(1):90-9.
1999: Ishikawa M; Saito Y; Miyamoto Y; Harada M; Kuwahara K; Ogawa E; Nakagawa O; Hamanaka I; Kajiyama N; Takahashi N; Masuda I; Hashimoto T; Sakai O; Hosoya T; Nakao K
A heart-specific increase in cardiotrophin-1 gene expression precedes the establishment of ventricular hypertrophy in genetically hypertensive rats.
Journal of hypertension 1999;17(6):807-16.
1999: Kuwahara K; Saito Y; Nakagawa O; Kishimoto I; Harada M; Ogawa E; Miyamoto Y; Hamanaka I; Kajiyama N; Takahashi N; Izumi T; Kawakami R; Tamura N; Ogawa Y; Nakao K
The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes--possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy.
FEBS letters 1999;452(3):314-8.
1999: Tanaka T; Itoh H; Doi K; Fukunaga Y; Hosoda K; Shintani M; Yamashita J; Chun T H; Inoue M; Masatsugu K; Sawada N; Saito T; Inoue G; Nishimura H; Yoshimasa Y; Nakao K
Down regulation of peroxisome proliferator-activated receptorgamma expression by inflammatory cytokines and its reversal by thiazolidinediones.
Diabetologia 1999;42(6):702-10.
1999: Nakayama M; Yasue H; Yoshimura M; Shimasaki Y; Kugiyama K; Ogawa H; Motoyama T; Saito Y; Ogawa Y; Miyamoto Y; Nakao K
T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm.
Circulation 1999;99(22):2864-70.
1999: Sobajima J; Ozaki S; Uesugi H; Osakada F; Inoue M; Fukuda Y; Shirakawa H; Yoshida M; Rokuhara A; Imai H; Kiyosawa K; Nakao K
High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 are significant target antigens of perinuclear anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis.
Gut 1999;44(6):867-73.
1999: Mori K; Ogawa Y; Ebihara K; Tamura N; Tashiro K; Kuwahara T; Mukoyama M; Sugawara A; Ozaki S; Tanaka I; Nakao K
Isolation and characterization of CA XIV, a novel membrane-bound carbonic anhydrase from mouse kidney.
The Journal of biological chemistry 1999;274(22):15701-5.
1999: Ozaki J; Shimizu H; Hashimoto Y; Itoh H; Nakao K; Inui K
Enzymatic inactivation of major circulating forms of atrial and brain natriuretic peptides.
European journal of pharmacology 1999;370(3):307-12.
1999: Yamasaki M; Emoto H; Konishi M; Mikami T; Ohuchi H; Nakao K; Itoh N
FGF-10 is a growth factor for preadipocytes in white adipose tissue.
Biochemical and biophysical research communications 1999;258(1):109-12.
1999: Nakamura Y; Usui T; Mizuta H; Murabe H; Muro S; Suda M; Tanaka K; Tanaka I; Shimatsu A; Nakao K
Characterization of Prophet of Pit-1 gene expression in normal pituitary and pituitary adenomas in humans.
The Journal of clinical endocrinology and metabolism 1999;84(4):1414-9.
1999: Akamizu T; Moriyama K; Miura M; Saijo M; Matsuda F; Nakao K
Characterization of recombinant monoclonal antithyrotropin receptor antibodies (TSHRAbs) derived from lymphocytes of patients with Graves' disease: epitope and binding study of two stimulatory TSHRAbs.
Endocrinology 1999;140(4):1594-601.
1999: Shimatsu A; Murabe H; Nakamura Y; Mizuta H; Ihara C; Nakao K
Long-term treatment with bromocriptine of a plurihormonal pituitary adenoma secreting thyrotropin, growth hormone and prolactin.
Endocrine journal 1999;46(1):159-65.
1999: Shimatsu A; Murabe H; Kamoi K; Suzuki Y; Nakao K
Treatment of thyrotropin-secreting pituitary adenomas with octreotide.
Endocrine journal 1999;46(1):113-23.
1999: Ogawa Y; Masuzaki H; Nakao K
Clinical implication of leptin, the obese gene product.
Internal medicine (Tokyo, Japan) 1999;38(2):210-2.
1999: Murakami M; Ozaki S; Nakao K
[Polyarteritis nodosa]
Nippon rinsho. Japanese journal of clinical medicine 1999;57(2):349-54.
1999: Hattori N; Tamaki N; Masuda I; Taniguchi Y; Kitano H; Kudoh T; Inubushi M; Tadamura E; Magata Y; Nakao K; Konishi J
An ultrashort 1-day protocol of Tc-99m tetrofosmin.
Clinical nuclear medicine 1999;24(2):85-91.
1998: Imagawa K; Numata Y; Katsuura G; Sakaguchi I; Morita A; Kikuoka S; Matumoto Y; Tsuji T; Tamaki M; Sasakura K; Teraoka H; Hosoda K; Ogawa Y; Nakao K
Structure-function studies of human leptin.
The Journal of biological chemistry 1998;273(52):35245-9.
1998: Hattori N; Tamaki N; Kudoh T; Masuda I; Magata Y; Kitano H; Inubushi M; Tadamura E; Nakao K; Konishi J
Abnormality of myocardial oxidative metabolism in noninsulin-dependent diabetes mellitus.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1998;39(11):1835-40.
1998: Inoue M; Itoh H; Ueda M; Naruko T; Kojima A; Komatsu R; Doi K; Ogawa Y; Tamura N; Takaya K; Igaki T; Yamashita J; Chun T H; Masatsugu K; Becker A E; Nakao K
Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions: possible pathophysiological significance of VEGF in progression of atherosclerosis.
Circulation 1998;98(20):2108-16.
1998: Matsuda J; Hosoda K; Itoh H; Son C; Doi K; Hanaoka I; Inoue G; Nishimura H; Yoshimasa Y; Yamori Y; Odaka H; Nakao K
Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes.
Diabetes 1998;47(11):1809-14.
1998: Yura S; Sagawa N; Ogawa Y; Masuzaki H; Mise H; Matsumoto T; Ebihara K; Fujii S; Nakao K
Augmentation of leptin synthesis and secretion through activation of protein kinases A and C in cultured human trophoblastic cells.
The Journal of clinical endocrinology and metabolism 1998;83(10):3609-14.
1998: Imagawa K; Matsumoto Y; Numata Y; Morita A; Kikuoka S; Tamaki M; Higashikubo C; Tsuji T; Sasakura K; Teraoka H; Masuzaki H; Hosoda K; Ogawa Y; Nakao K
Development of a sensitive ELISA for human leptin, using monoclonal antibodies.
Clinical chemistry 1998;44(10):2165-71.
1998: Nakamura Y; Shimatsu A; Murabe H; Mizuta H; Ihara C; Nakao K
Calcitonin gene-related peptide as a GH secretagogue in human and rat pituitary somatotrophs.
Brain research 1998;807(1-2):203-7.
1998: Tanaka M; Ozaki S; Osakada F; Mori K; Okubo M; Nakao K
Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases.
International immunology 1998;10(9):1305-14.
1998: Yamaguchi M; Hashimoto Y; Itoh H; Nakao K; Inui K
Effect of neutral endopeptidase inhibition on the natriuresis and renal clearance of atrial natriuretic peptide in perfused rat kidney.
Pharmaceutical research 1998;15(9):1499-502.
1998: Ikeda K; Tojo K; Sato S; Ebisawa T; Tokudome G; Hosoya T; Harada M; Nakagawa O; Nakao K
Urocortin, a newly identified corticotropin-releasing factor-related mammalian peptide, stimulates atrial natriuretic peptide and brain natriuretic peptide secretions from neonatal rat cardiomyocytes.
Biochemical and biophysical research communications 1998;250(2):298-304.
1998: Mise H; Sagawa N; Matsumoto T; Yura S; Nanno H; Itoh H; Mori T; Masuzaki H; Hosoda K; Ogawa Y; Nakao K
Augmented placental production of leptin in preeclampsia: possible involvement of placental hypoxia.
The Journal of clinical endocrinology and metabolism 1998;83(9):3225-9.
1998: Yoshimura M; Yasue H; Nakayama M; Shimasaki Y; Sumida H; Sugiyama S; Kugiyama K; Ogawa H; Ogawa Y; Saito Y; Miyamoto Y; Nakao K
A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese.
Human genetics 1998;103(1):65-9.
1998: Takaya K; Ogawa Y; Masuzaki H; Matsuoka N; Hosoda K; Nakao K
[Leptin Receptor]
Nippon rinsho. Japanese journal of clinical medicine 1998;56(7):1925-30.
1998: Murabe H; Mukoyama M; Tanaka I; Nakao K
[Adrenomedullin receptors]
Nippon rinsho. Japanese journal of clinical medicine 1998;56(7):1919-24.
1998: Miyamoto Y; Saito Y; Kajiyama N; Yoshimura M; Shimasaki Y; Nakayama M; Kamitani S; Harada M; Ishikawa M; Kuwahara K; Ogawa E; Hamanaka I; Takahashi N; Kaneshige T; Teraoka H; Akamizu T; Azuma N; Yoshimasa Y; Yoshimasa T; Itoh H; Masuda I; Yasue H; Nakao K
Endothelial nitric oxide synthase gene is positively associated with essential hypertension.
Hypertension 1998;32(1):3-8.
1998: Satoh N; Ogawa Y; Katsuura G; Numata Y; Masuzaki H; Yoshimasa Y; Nakao K
Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system.
Neuroscience letters 1998;249(2-3):107-10.
1998: Nanno H; Sagawa N; Itoh H; Matsumoto T; Terakawa K; Mori T; Itoh H; Nakao K
Nitric oxide metabolite concentrations in maternal plasma decrease during parturition: possible transient down-regulation of nitric oxide synthesis.
Molecular human reproduction 1998;4(6):609-16.
1998: Yamashita J; Yoshimasa T; Arai H; Hiraoka J; Takaya K; Miyamoto Y; Ogawa Y; Itoh H; Nakao K
Identification of cis-elements of the human endothelin-A receptor gene and inhibition of the gene expression by the decoy strategy.
The Journal of biological chemistry 1998;273(26):15993-9.
1998: Yura S; Sagawa N; Mise H; Mori T; Masuzaki H; Ogawa Y; Nakao K
A positive umbilical venous-arterial difference of leptin level and its rapid decline after birth.
American journal of obstetrics and gynecology 1998;178(5):926-30.
1998: Numata Y; Dohi K; Furukawa A; Kikuoka S; Asada H; Fukunaga T; Taniguchi Y; Sasakura K; Tsuji T; Inouye K; Yoshimura M; Itoh H; Mukoyama M; Yasue H; Nakao K
Immunoradiometric assay for the N-terminal fragment of proatrial natriuretic peptide in human plasma.
Clinical chemistry 1998;44(5):1008-13.
1998: Yasoda A; Ogawa Y; Suda M; Tamura N; Mori K; Sakuma Y; Chusho H; Shiota K; Tanaka K; Nakao K
Natriuretic peptide regulation of endochondral ossification. Evidence for possible roles of the C-type natriuretic peptide/guanylyl cyclase-B pathway.
The Journal of biological chemistry 1998;273(19):11695-700.
1998: Nakamura Y; Shimatsu A; Murabe H; Mizuta H; Ihara C; Nakao K
Calcitonin gene-related peptide (CGRP) as a GH secretagogue in rat and human pituitary tumoral cells.
Endocrine journal 1998;45 Suppl():S89-91.
1998: Uesugi H; Ozaki S; Sobajima J; Osakada F; Shirakawa H; Yoshida M; Nakao K
Prevalence and characterization of novel pANCA, antibodies to the high mobility group non-histone chromosomal proteins HMG1 and HMG2, in systemic rheumatic diseases.
The Journal of rheumatology 1998;25(4):703-9.
1998: Michibata H; Mukoyama M; Tanaka I; Suga S; Nakagawa M; Ishibashi R; Goto M; Akaji K; Fujiwara Y; Kiso Y; Nakao K
Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells.
Kidney international 1998;53(4):979-85.
1998: Azuma N; Yoshimasa Y; Nishimura H; Yamamoto Y; Masuzaki H; Suga J; Shigemoto M; Matsuoka N; Tanaka T; Satoh N; Igaki T; Miyamoto Y; Itoh H; Yoshimasa T; Hosoda K; Nishi S; Nakao K
The significance of the Trp 64 Arg mutation of the beta3-adrenergic receptor gene in impaired glucose tolerance, non-insulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects.
Metabolism: clinical and experimental 1998;47(4):456-60.
1998: Suga S I; Itoh H; Komatsu Y; Ishida H; Igaki T; Yamashita J; Doi K; Chun T H; Yoshimasa T; Tanaka I; Nakao K
Regulation of endothelial production of C-type natriuretic peptide by interaction between endothelial cells and macrophages.
Endocrinology 1998;139(4):1920-6.
1998: Suda M; Tanaka K; Yasoda A; Natsui K; Sakuma Y; Tanaka I; Ushikubi F; Narumiya S; Nakao K
Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells.
Calcified tissue international 1998;62(4):327-31.
1998: Shigemoto M; Yoshimasa Y; Yamamoto Y; Hayashi T; Suga J; Inoue G; Okamoto M; Jingami H; Tsuda K; Yamamoto T; Yagura T; Oishi M; Tsujii S; Kuzuya H; Nakao K
Clinical manifestations due to a point mutation of the mitochondrial tRNAleu(UUR) gene in five families with diabetes mellitus.
Internal medicine (Tokyo, Japan) 1998;37(3):265-72.
1998: Amenomori M; Mori T; Fukuda Y; Sugawa H; Nishida N; Furukawa M; Kita R; Sando T; Komeda T; Nakao K
Incidence and characteristics of thyroid dysfunction following interferon therapy in patients with chronic hepatitis C.
Internal medicine (Tokyo, Japan) 1998;37(3):246-52.
1998: Igaki T; Itoh H; Suga S I; Hama N; Ogawa Y; Komatsu Y; Yamashita J; Doi K; Chun T H; Nakao K
Effects of intravenously administered C-type natriuretic peptide in humans: comparison with atrial natriuretic peptide.
Hypertension research : official journal of the Japanese Society of Hypertension 1998;21(1):7-13.
1998: Suda M; Ogawa Y; Tanaka K; Tamura N; Yasoda A; Takigawa T; Uehira M; Nishimoto H; Itoh H; Saito Y; Shiota K; Nakao K
Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2337-42.
1998: Miyoshi Y; Nakamura H; Tagami T; Sasaki S; Dorin R I; Taniyama M; Nakao K
Comparison of the functional properties of three different truncated thyroid hormone receptors identified in subjects with resistance to thyroid hormone.
Molecular and cellular endocrinology 1998;137(2):169-76.
1998: Sobajima J; Ozaki S; Uesugi H; Osakada F; Shirakawa H; Yoshida M; Nakao K
Prevalence and characterization of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) directed against HMG1 and HMG2 in ulcerative colitis (UC).
Clinical and experimental immunology 1998;111(2):402-7.
1998: Takashima Y; Taniguchi T; Yoshida M; Haque M S; Igaki T; Itoh H; Nakao K; Honda Y; Yoshimura N
Ocular hypotension induced by intravitreally injected C-type natriuretic peptide.
Experimental eye research 1998;66(1):89-96.
1998: Harada M; Saito Y; Kuwahara K; Ogawa E; Ishikawa M; Nakagawa O; Miyamoto Y; Kamitani S; Hamanaka I; Kajiyama N; Takahashi N; Masuda I; Itoh H; Nakao K
Interaction of myocytes and nonmyocytes is necessary for mechanical stretch to induce ANP/BNP production in cardiocyte culture.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S357-9.
1998: Kuwahara K; Saito Y; Ogawa Y; Tamura N; Ishikawa M; Harada M; Ogawa E; Miyamoto Y; Hamanaka I; Kamitani S; Kajiyama N; Takahashi N; Nakagawa O; Masuda I; Nakao K
Endothelin-1 and cardiotrophin-1 induce brain natriuretic peptide gene expression by distinct transcriptional mechanisms.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S354-6.
1998: Saito T; Itoh H; Chun T; Igaki T; Mori Y; Yamashita J; Doi K; Tanaka T; Inoue M; Masatsugu K; Fukunaga Y; Sawada N; Tojo K; Saito Y; Hosoya T; Nakao K
Oxidative stress suppresses the endothelial secretion of endothelin.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S345-7.
1998: Masatsugu K; Itoh H; Chun T H; Ogawa Y; Tamura N; Yamashita J; Doi K; Inoue M; Fukunaga Y; Sawada N; Saito T; Korenaga R; Ando J; Nakao K
Physiologic shear stress suppresses endothelin-converting enzyme-1 expression in vascular endothelial cells.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S42-5.
1997: Mizuno Y; Yasue H; Oshima S; Yoshimura M; Ogawa H; Morita E; Saito T; Yamashita S; Noda K; Sumida H; Motoyama T; Soejima H; Nakao K
Effects of angiotensin-converting enzyme inhibitor on plasma B-type natriuretic peptide levels in patients with acute myocardial infarction.
Journal of cardiac failure 1997;3(4):287-93.
1997: Ebihara K; Ogawa Y; Isse N; Mori K; Tamura N; Masuzaki H; Kohno K; Yura S; Hosoda K; Sagawa N; Nakao K
Identification of the human leptin 5'-flanking sequences involved in the trophoblast-specific transcription.
Biochemical and biophysical research communications 1997;241(3):658-63.
1997: Matsuda J; Hosoda K; Itoh H; Son C; Doi K; Tanaka T; Fukunaga Y; Inoue G; Nishimura H; Yoshimasa Y; Yamori Y; Nakao K
Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet.
FEBS letters 1997;418(1-2):200-4.
1997: Mori K; Ogawa Y; Ebihara K; Aoki T; Tamura N; Sugawara A; Kuwahara T; Ozaki S; Mukoyama M; Tashiro K; Tanaka I; Nakao K
Kidney-specific expression of a novel mouse organic cation transporter-like protein.
FEBS letters 1997;417(3):371-4.
1997: Shigemoto M; Nishi S; Ogawa Y; Isse N; Matsuoka N; Tanaka T; Azuma N; Masuzaki H; Nishimura H; Yoshimasa Y; Hosoda K; Nakao K
Molecular screening of both the promoter and the protein coding regions in the human ob gene in Japanese obese subjects with non-insulin-dependent diabetes mellitus.
European journal of endocrinology / European Federation of Endocrine Societies 1997;137(5):511-3.
1997: Harada M; Itoh H; Nakagawa O; Ogawa Y; Miyamoto Y; Kuwahara K; Ogawa E; Igaki T; Yamashita J; Masuda I; Yoshimasa T; Tanaka I; Saito Y; Nakao K
Significance of ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy: evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes.
Circulation 1997;96(10):3737-44.
1997: Akamizu T; Mori T; Nakao K
Pathogenesis of Graves' disease: molecular analysis of anti-thyrotropin receptor antibodies.
Endocrine journal 1997;44(5):633-46.
1997: Nishimura H; Hosoda K; Ogawa Y; Nakao K
[ob gene (leptin gene)]
Nippon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():482-9.
1997: Doi K; Itoh H; Ikeda T; Hosoda K; Ogawa Y; Igaki T; Yamashita J; Chun T H; Inoue M; Masatsugu K; Matsuda K; Ohmori K; Nakao K
Adenovirus-mediated gene transfer of C-type natriuretic peptide causes G1 growth inhibition of cultured vascular smooth muscle cells.
Biochemical and biophysical research communications 1997;239(3):889-94.
1997: Matsuoka N; Ogawa Y; Hosoda K; Matsuda J; Masuzaki H; Miyawaki T; Azuma N; Natsui K; Nishimura H; Yoshimasa Y; Nishi S; Thompson D B; Nakao K
Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity.
Diabetologia 1997;40(10):1204-10.
1997: Nishida N; Fukuda Y; Ishizaki K; Nakao K
Alteration of cell cycle-related genes in hepatocarcinogenesis.
Histology and histopathology 1997;12(4):1019-25.
1997: Tagami T; Nakamura H; Sasaki S; Miyoshi Y; Nakao K
Dimerization properties of mutant thyroid hormone beta-receptors with auxiliary proteins.
The Journal of endocrinology 1997;154(3):523-33.
1997: Matsumoto T; Sagawa N; Yoshida M; Mori T; Tanaka I; Mukoyama M; Kotani M; Nakao K
The prostaglandin E2 and F2 alpha receptor genes are expressed in human myometrium and are down-regulated during pregnancy.
Biochemical and biophysical research communications 1997;238(3):838-41.
1997: Goto M; Mukoyama M; Suga S; Matsumoto T; Nakagawa M; Ishibashi R; Kasahara M; Sugawara A; Tanaka I; Nakao K
Growth-dependent induction of angiotensin II type 2 receptor in rat mesangial cells.
Hypertension 1997;30(3 Pt 1):358-62.
1997: Araki E; Nakamura K; Nakao K; Kameya S; Kobayashi O; Nonaka I; Kobayashi T; Katsuki M
Targeted disruption of exon 52 in the mouse dystrophin gene induced muscle degeneration similar to that observed in Duchenne muscular dystrophy.
Biochemical and biophysical research communications 1997;238(2):492-7.
1997: Miyoshi Y; Nakao K
A mutant thyroid hormone receptor beta 1 identified in a patient with resistance to thyroid hormone inhibits the activities of not only the wild-type TRs, but also other nuclear receptors.
Biochemical and biophysical research communications 1997;238(1):39-43.
1997: Nakao K; Ohgushi M; Yoshimura M; Morooka K; Okumura K; Ogawa H; Kugiyama K; Oike Y; Fujimoto K; Yasue H
Hyperventilation as a specific test for diagnosis of coronary artery spasm.
The American journal of cardiology 1997;80(5):545-9.
1997: Masuzaki H; Ogawa Y; Sagawa N; Hosoda K; Matsumoto T; Mise H; Nishimura H; Yoshimasa Y; Tanaka I; Mori T; Nakao K
Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans.
Nature medicine 1997;3(9):1029-33.
1997: Itoh H; Nakao K
[Natriuretic peptide system]
Nippon rinsho. Japanese journal of clinical medicine 1997;55(8):1923-36.
1997: Masuzaki H; Ogawa Y; Hosoda K; Miyawaki T; Hanaoka I; Hiraoka J; Yasuno A; Nishimura H; Yoshimasa Y; Nishi S; Nakao K
Glucocorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing's syndrome.
The Journal of clinical endocrinology and metabolism 1997;82(8):2542-7.
1997: Sasaki Y; Takahashi T; Tanaka I; Nakamura K; Okuno Y; Nakagawa O; Narumiya S; Nakao K
Expression of prostacyclin receptor in human megakaryocytes.
Blood 1997;90(3):1039-46.
1997: Nakao K; Inoue Y; Okabe K; Kawarabayashi T; Kitamura K
Oxytocin enhances action potentials in pregnant human myometrium--a study with microelectrodes.
American journal of obstetrics and gynecology 1997;177(1):222-8.
1997: Itoh H; Sagawa N; Nanno H; Mori T; Mukoyama M; Itoh H; Nakao K
Impaired guanosine 3',5'-cyclic phosphate production in severe pregnancy-induced hypertension with high plasma levels of atrial and brain natriuretic peptides.
Endocrine journal 1997;44(3):389-93.
1997: Watanabe N; Madaule P; Reid T; Ishizaki T; Watanabe G; Kakizuka A; Saito Y; Nakao K; Jockusch B M; Narumiya S
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.
The EMBO journal 1997;16(11):3044-56.
1997: Chun T H; Itoh H; Ogawa Y; Tamura N; Takaya K; Igaki T; Yamashita J; Doi K; Inoue M; Masatsugu K; Korenaga R; Ando J; Nakao K
Shear stress augments expression of C-type natriuretic peptide and adrenomedullin.
Hypertension 1997;29(6):1296-302.
1997: Kobayashi H; Fukata J; Murakami N; Usui T; Ebisui O; Muro S; Hanaoka I; Inoue K; Imura H; Nakao K
Tumor necrosis factor receptors in the pituitary cells.
Brain research 1997;758(1-2):45-50.
1997: Suga J; Yoshimasa Y; Yamada K; Yamamoto Y; Inoue G; Okamoto M; Hayashi T; Shigemoto M; Kosaki A; Kuzuya H; Nakao K
Differential activation of mitogen-activated protein kinase by insulin and epidermal growth factor in 3T3-L1 adipocytes: a possible involvement of PI3-kinase in the activation of the MAP kinase by insulin.
Diabetes 1997;46(5):735-41.
1997: Itoh H; Suga S; Ogawa Y; Komatsu Y; Tamura N; Igaki T; Yamashita J; Ikeda T; Doi K; Chun T H; Inoue M; Matsuda K; Yoshimasa T; Ueda M; Ban T; Nakao K
Significance of vascular natriuretic peptide system in vascular remodeling in humans and its application to gene therapy.
Annals of the New York Academy of Sciences 1997;811():533-41.
1997: Fukui Y; Ishimoto T; Utsuyama M; Gyotoku T; Koga T; Nakao K; Hirokawa K; Katsuki M; Sasazuki T
Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus.
Immunity 1997;6(4):401-10.
1997: Satoh N; Ogawa Y; Katsuura G; Hayase M; Tsuji T; Imagawa K; Yoshimasa Y; Nishi S; Hosoda K; Nakao K
The arcuate nucleus as a primary site of satiety effect of leptin in rats.
Neuroscience letters 1997;224(3):149-52.
1997: Kotani M; Tanaka I; Ogawa Y; Usui T; Tamura N; Mori K; Narumiya S; Yoshimi T; Nakao K
Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3).
Genomics 1997;40(3):425-34.
1997: Ikeda T; Matsuda K; Itoh H; Shirakami G; Miyamoto Y; Yoshimasa T; Nakao K; Ban T
Plasma levels of brain and atrial natriuretic peptides elevate in proportion to left ventricular end-systolic wall stress in patients with aortic stenosis.
American heart journal 1997;133(3):307-14.
1997: Satoh N; Ogawa Y; Katsuura G; Tsuji T; Masuzaki H; Hiraoka J; Okazaki T; Tamaki M; Hayase M; Yoshimasa Y; Nishi S; Hosoda K; Nakao K
Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: evidence for loss of its satiety effect in VMH-lesioned rats.
Endocrinology 1997;138(3):947-54.
1997: Yamamoto T; Yoshimasa Y; Koshiyama H; Sugiyama K; Okigaki M; Yamada T; Ishii H; Yagura T; Fujimoto K; Ohnishi T; Koh T; Hino M; Kurahachi H; Yoshimasa T; Nakao K
Lack of mutations of preproparathyroid hormone gene in three kindreds with familial isolated hypoparathyroidism.
Endocrine journal 1997;44(1):175-80.
1997: Hiraoka J; Hosoda K; Ogawa Y; Ikeda K; Nara Y; Masuzaki H; Takaya K; Nakagawa K; Mashimo T; Sawamura M; Koletsky R J; Yamori Y; Nakao K
Augmentation of obese (ob) gene expression and leptin secretion in obese spontaneously hypertensive rats (obese SHR or Koletsky rats).
Biochemical and biophysical research communications 1997;231(3):582-5.
1997: Yamashita J; Itoh H; Ogawa Y; Tamura N; Takaya K; Igaki T; Doi K; Chun T H; Inoue M; Masatsugu K; Nakao K
Opposite regulation of Gax homeobox expression by angiotensin II and C-type natriuretic peptide.
Hypertension 1997;29(1 Pt 2):381-7.
1997: Soma M; Maeda Y; Matsuura R; Sasaki I; Kasakura S; Saeki Y; Ikekubo K; Ishihara T; Kurahachi H; Sasaki S; Tagami T; Nakao K
[Study of serum thrombomodulin(TM) levels in patients with hyper- or hypo- thyroidism]
Rinsho byori. The Japanese journal of clinical pathology 1997;45(1):77-81.
1997: Mori K; Ogawa Y; Tamura N; Ebihara K; Aoki T; Muro S; Ozaki S; Tanaka I; Tashiro K; Nakao K
Molecular cloning of a novel mouse aspartic protease-like protein that is expressed abundantly in the kidney.
FEBS letters 1997;401(2-3):218-22.
1997: Sobajima J; Ozaki S; Osakada F; Uesugi H; Shirakawa H; Yoshida M; Nakao K
Novel autoantigens of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) in ulcerative colitis: non-histone chromosomal proteins, HMG1 and HMG2.
Clinical and experimental immunology 1997;107(1):135-40.
1997: Harada M; Saito Y; Nakagawa O; Miyamoto Y; Ishikawa M; Kuwahara K; Ogawa E; Nakayama M; Kamitani S; Hamanaka I; Kajiyama N; Masuda I; Itoh H; Tanaka I; Nakao K
Role of cardiac nonmyocytes in cyclic mechanical stretch-induced myocyte hypertrophy.
Heart and vessels 1997;Suppl 12():198-200.
1997: Doi K; Itoh H; Nakagawa O; Igaki T; Yamashita J; Chun T H; Inoue M; Masatsugu K; Nakao K
Expression of natriuretic peptide system during embryonic stem cell vasculogenesis.
Heart and vessels 1997;Suppl 12():18-22.
1996: Tagami T; Tanaka K; Sugawa H; Nakamura H; Miyoshi Y; Mori T; Nakao K
High-dose intravenous steroid pulse therapy in thyroid-associated ophthalmopathy.
Endocrine journal 1996;43(6):689-99.
1996: Ihara C; Shimatsu A; Murabe H; Kataoka K; Kondo C; Nakao K
Growth hormone-secreting pituitary adenoma associated with multiple bone cysts, skin pigmentation and aortitis syndrome.
Journal of endocrinological investigation 1996;19(11):753-7.
1996: Hattori N; Tamaki N; Hayashi T; Masuda I; Kudoh T; Tateno M; Tadamura E; Yonekura Y; Nakao K; Konishi J
Regional abnormality of iodine-123-MIBG in diabetic hearts.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996;37(12):1985-90.
1996: Matsumoto T; Sagawa N; Mukoyama M; Tanaka I; Itoh H; Goto M; Itoh H; Horiuchi M; Dzau V J; Mori T; Nakao K
Type 2 angiotensin II receptor is expressed in human myometrium and uterine leiomyoma and is down-regulated during pregnancy.
The Journal of clinical endocrinology and metabolism 1996;81(12):4366-72.
1996: Nakao K; Saito Y; Itoh H; Ogawa Y; Nakagawa O; Harada M; Masuda I; Yoshimasa T
Roles of natriuretic peptides in heart failure.
Journal of cardiac failure 1996;2(4 Suppl):S129-33.
1996: Okazaki T; Ogawa Y; Tamura N; Mori K; Isse N; Aoki T; Rochelle J M; Taketo M M; Seldin M F; Nakao K
Genomic organization, expression, and chromosomal mapping of the mouse adrenomedullin gene.
Genomics 1996;37(3):395-9.
1996: Takaya K; Yoshimasa T; Arai H; Tamura N; Miyamoto Y; Itoh H; Nakao K
Expression of the RET proto-oncogene in normal human tissues, pheochromocytomas, and other tumors of neural crest origin.
Journal of molecular medicine (Berlin, Germany) 1996;74(10):617-21.
1996: Matsuoka N; Jingami H; Masuzaki H; Mizuno M; Nakaishi S; Suga J; Tanaka T; Yamamoto T; Nakao K
Effects of gemfibrozil administration on very low density lipoprotein receptor mRNA levels in rabbits.
Atherosclerosis 1996;126(2):221-6.
1996: Takaya K; Ogawa Y; Hiraoka J; Hosoda K; Yamori Y; Nakao K; Koletsky R J
Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat.
Nature genetics 1996;14(2):130-1.
1996: Hokimoto S; Yasue H; Fujimoto K; Yamamoto H; Nakao K; Kaikita K; Sakata R; Miyamoto E
Expression of angiotensin-converting enzyme in remaining viable myocytes of human ventricles after myocardial infarction.
Circulation 1996;94(7):1513-8.
1996: Yoshibayashi M; Saito Y; Nakao K
Brain natriuretic peptide versus atrial natriuretic peptide--physiological and pathophysiological significance in children and adults: a review.
European journal of endocrinology / European Federation of Endocrine Societies 1996;135(3):265-8.
1996: Sakaguchi H; Inoue D; Kataoka K; Koshiyama H; Aoki N; Nakao K
Two cases of empty sella syndrome with variable dexamethasone-suppressibility of ACTH and cortisol.
Endocrine journal 1996;43(4):417-22.
1996: Ihara C; Shimatsu A; Mizuta H; Murabe H; Nakamura Y; Nakao K
Decreased neurotrophin-3 expression in skeletal muscles of streptozotocin-induced diabetic rats.
Neuropeptides 1996;30(4):309-12.
1996: Natsui K; Tanaka K; Suda M; Yasoda A; Yonemitsu S; Nakao K
Spontaneous remission of primary hyperparathyroidism due to hemorrhagic infarction in the parathyroid adenoma.
Internal medicine (Tokyo, Japan) 1996;35(8):646-9.
1996: Tamura N; Ogawa Y; Yasoda A; Itoh H; Saito Y; Nakao K
Two cardiac natriuretic peptide genes (atrial natriuretic peptide and brain natriuretic peptide) are organized in tandem in the mouse and human genomes.
Journal of molecular and cellular cardiology 1996;28(8):1811-5.
1996: Murabe H; Shimatsu A; Ihara C; Mizuta H; Nakamura Y; Nagata I; Kikuchi H; Nakao K
Expression of somatostatin receptor (SSTR) subtypes in pituitary adenomas: quantitative analysis of SSTR2 mRNA by reverse transcription-polymerase chain reaction.
Journal of neuroendocrinology 1996;8(8):605-10.
1996: Nakagawa O; Fujisawa K; Ishizaki T; Saito Y; Nakao K; Narumiya S
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice.
FEBS letters 1996;392(2):189-93.
1996: Hayase M; Ogawa Y; Katsuura G; Shintaku H; Hosoda K; Nakao K
Regulation of obese gene expression in KK mice and congenic lethal yellow obese KKAy mice.
The American journal of physiology 1996;271(2 Pt 1):E333-9.
1996: Tagami T; Nakamura H; Sasaki S; Miyoshi Y; Nakao K
Starvation-induced decrease in the maximal binding capacity for triiodothyronine of the thyroid hormone receptor is due to a decrease in the receptor protein.
Metabolism: clinical and experimental 1996;45(8):970-3.
1996: Takaya K; Ogawa Y; Isse N; Okazaki T; Satoh N; Masuzaki H; Mori K; Tamura N; Hosoda K; Nakao K
Molecular cloning of rat leptin receptor isoform complementary DNAs--identification of a missense mutation in Zucker fatty (fa/fa) rats.
Biochemical and biophysical research communications 1996;225(1):75-83.
1996: Kugiyama K; Yasue H; Okumura K; Ogawa H; Fujimoto K; Nakao K; Yoshimura M; Motoyama T; Inobe Y; Kawano H
Nitric oxide activity is deficient in spasm arteries of patients with coronary spastic angina.
Circulation 1996;94(3):266-71.
1996: Natsui K; Tanaka K; Suda M; Yasoda A; Shigeno C; Konishi J; Nakao K
Oxyphil parathyroid adenoma associated with primary hyperparathyroidism and marked post-operative hungry bone syndrome.
Internal medicine (Tokyo, Japan) 1996;35(7):545-9.
1996: Koshiyama H; Sellitti D F; Akamizu T; Doi S Q; Takeuchi Y; Inoue D; Sakaguchi H; Takemura G; Sato Y; Takatsu Y; Nakao K
Cardiomyopathy associated with Graves' disease.
Clinical endocrinology 1996;45(1):111-6.
1996: Kita R; Nishida N; Fukuda Y; Azechi H; Matsuoka Y; Komeda T; Sando T; Nakao K; Ishizaki K
Infrequent alterations of the p16INK4A gene in liver cancer.
International journal of cancer. Journal international du cancer 1996;67(2):176-80.
1996: Kikuta K; Yasue H; Yoshimura M; Morita E; Sumida H; Kato H; Kugiyama K; Ogawa H; Okumura K; Ogawa Y; Nakao K
Increased plasma levels of B-type natriuretic peptide in patients with unstable angina.
American heart journal 1996;132(1 Pt 1):101-7.
1996: Sumita S; Ozaki S; Okazaki T; Sobajima J; Nakao K
A vascular smooth muscle-specific CD4+ T cell line that induces pulmonary vasculitis in MRL-+/+ mice.
Clinical and experimental immunology 1996;105(1):163-8.
1996: Sobajima J; Ozaki S; Okazaki T; Osakada F; Sumita S; Mori K; Nakao K
Anti-neutrophil cytoplasmic antibodies (ANCA) in ulcerative colitis: anti-cathepsin G and a novel antibody correlate with a refractory type.
Clinical and experimental immunology 1996;105(1):120-4.
1996: Igaki T; Itoh H; Suga S; Komatsu Y; Ogawa Y; Doi K; Yoshimasa T; Nakao K
Insulin suppresses endothelial secretion of C-type natriuretic peptide, a novel endothelium-derived relaxing peptide.
Diabetes 1996;45 Suppl 3():S62-4.
1996: Mori K; Tanaka I; Kotani M; Miyaoka F; Sando T; Muro S; Sasaki Y; Nakagawa O; Ogawa Y; Usui T; Ozaki S; Ichikawa A; Narumiya S; Nakao K
Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester.
Journal of molecular medicine (Berlin, Germany) 1996;74(6):333-6.
1996: Takaya K; Yoshimasa T; Arai H; Tamura N; Miyamoto Y; Itoh H; Nakao K
The RET proto-oncogene in sporadic pheochromocytomas.
Internal medicine (Tokyo, Japan) 1996;35(6):449-52.
1996: Igaki T; Itoh H; Suga S; Hama N; Ogawa Y; Komatsu Y; Mukoyama M; Sugawara A; Yoshimasa T; Tanaka I; Nakao K
C-type natriuretic peptide in chronic renal failure and its action in humans.
Kidney international. Supplement 1996;55():S144-7.
1996: Tsuzuki T; Fujii Y; Sakumi K; Tominaga Y; Nakao K; Sekiguchi M; Matsushiro A; Yoshimura Y; MoritaT
Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6236-40.
1996: Suda M; Tanaka K; Fukushima M; Natsui K; Yasoda A; Komatsu Y; Ogawa Y; Itoh H; Nakao K
C-type natriuretic peptide as an autocrine/paracrine regulator of osteoblast. Evidence for possible presence of bone natriuretic peptide system.
Biochemical and biophysical research communications 1996;223(1):1-6.
1996: Segawa H; Mori K; Kasai K; Fukata J; Nakao K
The role of the phrenic nerves in stress response in upper abdominal surgery.
Anesthesia and analgesia 1996;82(6):1215-24.
1996: Komatsu Y; Itoh H; Suga S; Igaki T; Ogawa Y; Kishimoto I; Nakagawa O; Yoshimasa T; Nakao K
Regulation of secretion and clearance of C-type natriuretic peptide in the interaction of vascular endothelial cells and smooth muscle cells.
Journal of hypertension 1996;14(5):585-92.
1996: Hayashi T; Okamoto M; Yoshimasa Y; Inoue G; Yamada K; Kono S; Shigemoto M; Suga J; Kuzuya H; Nakao K
Insulin-induced activation of phosphoinositide 3-kinase in Fao cells.
Diabetologia 1996;39(5):515-22.
1996: Gondo Y; Shioyama Y; Nakao K; Katsuki M
A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice.
Mutation research 1996;360(1):1-14.
1996: Nakamura K; Takahashi T; Sasaki Y; Tsuyuoka R; Okuno Y; Kurino M; Ohmori K; Iho S; Nakao K
1,25-dihydroxyvitamin D3 differentiates normal neutrophilic promyelocytes to monocytes/macrophages in vitro.
Blood 1996;87(7):2693-701.
1996: Komatsu Y; Itoh H; Suga S; Ogawa Y; Hama N; Kishimoto I; Nakagawa O; Igaki T; Doi K; Yoshimasa T; Nakao K
Regulation of endothelial production of C-type natriuretic peptide in coculture with vascular smooth muscle cells. Role of the vascular natriuretic peptide system in vascular growth inhibition.
Circulation research 1996;78(4):606-14.
1996: Hosoda K; Masuzaki H; Ogawa Y; Miyawaki T; Hiraoka J; Hanaoka I; Yasuno A; Nomura T; Fujisawa Y; Yoshimasa Y; Nishi S; Yamori Y; Nakao K
Development of radioimmunoassay for human leptin.
Biochemical and biophysical research communications 1996;221(2):234-9.
1996: Ikeda T; Itoh H; Komatsu Y; Hanyu M; Yoshimasa T; Matsuda K; Nakao K; Ban T
Natriuretic peptide receptors in human artery and vein and rabbit vein graft.
Hypertension 1996;27(3 Pt 2):833-7.
1996: Doi K; Itoh H; Komatsu Y; Igaki T; Chun T H; Takaya K; Yamashita J; Inoue M; Yoshimasa T; Nakao K
Vascular endothelial growth factor suppresses C-type natriuretic peptide secretion.
Hypertension 1996;27(3 Pt 2):811-5.
1996: Tamura N; Itoh H; Ogawa Y; Nakagawa O; Harada M; Chun T H; Suga S; Yoshimasa T; Nakao K
cDNA cloning and gene expression of human type Ialpha cGMP-dependent protein kinase.
Hypertension 1996;27(3 Pt 2):552-7.
1996: Yamaguchi H; Aiba A; Nakamura K; Nakao K; Sakagami H; Goto K; Kondo H; Katsuki M
Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(2):253-68.
1996: Tsuyuoka R; Takahashi T; Shinoda E; Taniguchi Y; Nishibe K; Takeuchi E; Nakao K
Intestinal perforation in temporal arteritis, associated with paroxysmal nocturnal hemoglobinuria.
Internal medicine (Tokyo, Japan) 1996;35(2):159-61.
1996: Ishikawa M; Saito Y; Miyamoto Y; Kuwahara K; Ogawa E; Nakagawa O; Harada M; Masuda I; Nakao K
cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of CT-1 gene in ventricle of genetically hypertensive rats.
Biochemical and biophysical research communications 1996;219(2):377-81.
1996: Hasegawa K; Fujiwara H; Koshiji M; Inada T; Ohtani S; Doyama K; Tanaka M; Matsumori A; Fujiwara T; Shirakami G; Hosoda K; Nakao K; Sasayama S
Endothelin-1 and its receptor in hypertrophic cardiomyopathy.
Hypertension 1996;27(2):259-64.
1996: Shirakami G; Murakawa M; Shingu K; Mashima S; Suga S; Magaribuchi T; O'higashi T; Shichino T; Nakao K; Mori K
Perioperative plasma concentrations of endothelin and natriuretic peptides in children undergoing living-related liver transplantation.
Anesthesia and analgesia 1996;82(2):235-40.
1996: Nakao K; Itoh H; Saito Y; Mukoyama M; Ogawa Y
The natriuretic peptide family.
Current opinion in nephrology and hypertension 1996;5(1):4-11.
1996: Masuzaki H; Jingami H; Matsuoka N; Nakagawa O; Ogawa Y; Mizuno M; Yoshimasa Y; Yamamoto T; Nakao K
Regulation of very-low-density lipoprotein receptor in hypertrophic rat heart.
Circulation research 1996;78(1):8-14.
1996: Masuzaki H; Hosoda K; Ogawa Y; Shigemoto M; Satoh N; Mori K; Tamura N; Nishi S; Yoshimasa Y; Yamori Y; Nakao K
Augmented expression of obese (ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty (fa/fa) rats.
FEBS letters 1996;378(3):267-71.
1996: Hasegawa M; Sagawa N; Nanno H; Itoh H; Inamori K; Ihara Y; Kobayashi F; Mori T; Yano J; Shirakami G; Suga S; Ogawa Y; Yoshimasa T; Nakao K
Endothelin-1-like immunoreactivity and endothelin receptors in the human placenta from normotensive and hypertensive pregnancies.
Journal of perinatal medicine 1996;24(5):451-60.
1996: Mashima S; Shirakami G; Mitsuyoshi A; Nakagami M; Morimoto T; Terasaki M; Nakao K; Yamabe H; Yamaoka Y; Ozawa K
Evaluation of the protective effect of a novel prostacyclin analog on mesenteric circulation following warm ischemia.
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 1996;28(1):14-25.
1995: Jingami H; Masuzaki H; Matsuoka N; Nakagawa O; Ogawa Y; Mizuno M; Yamamoto T; Nakao K
Decreased expression of the very low density lipoprotein receptor mRNA in the cardiac ventricle of spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology. Supplement 1995;22(1):S246-8.
1995: Nakagawa O; Itoh H; Harada M; Komatsu Y; Yoshimasa T; Nakao K
Gene regulation of brain natriuretic peptide in cardiocyte hypertrophy by alpha1-adrenergic stimulation.
Clinical and experimental pharmacology & physiology. Supplement 1995;22(1):S183-5.
1995: Takemura G; Fujiwara H; Takatsu Y; Fujiwara T; Nakao K
Venticular expression of atrial and brain natriuretic peptides in patients with myocarditis.
International journal of cardiology 1995;52(3):213-22.
1995: Sugiyama S; Kugiyama K; Matsumura T; Suga S; Itoh H; Nakao K; Yasue H
Lipoproteins regulate C-type natriuretic peptide secretion from cultured vascular endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(11):1968-74.
1995: Masuzaki H; Ogawa Y; Hosoda K; Kawada T; Fushiki T; Nakao K
Augmented expression of the obese gene in the adipose tissue from rats fed high-fat diet.
Biochemical and biophysical research communications 1995;216(1):355-8.
1995: Kotani M; Tanaka I; Ogawa Y; Usui T; Mori K; Ichikawa A; Narumiya S; Yoshimi T; Nakao K
Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions.
Molecular pharmacology 1995;48(5):869-79.
1995: Miyoshi Y; Nakamura H; Sasaki S; Tagami T; Misaki T; Konishi J; Nakao K
Two consecutive nucleotide substitutions resulting in the T3 receptor beta gene resulting in an 11-amino acid truncation in a patient with generalized resistance to thyroid hormone.
Molecular and cellular endocrinology 1995;114(1-2):9-17.
1995: Ogawa Y; Itoh H; Nakagawa O; Shirakami G; Tamura N; Yoshimasa T; Nagata K; Yoshida N; Nakao K
Characterization of the 5'-flanking region and chromosomal assignment of the human brain natriuretic peptide gene.
Journal of molecular medicine (Berlin, Germany) 1995;73(9):457-63.
1995: Nakagawa O; Ogawa Y; Itoh H; Suga S; Komatsu Y; Kishimoto I; Nishino K; Yoshimasa T; Nakao K
Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload.
The Journal of clinical investigation 1995;96(3):1280-7.
1995: Sasaki S; Nakamura H; Tagami T; Miyoshi Y; Nakao K
Functional properties of a mutant T3 receptor beta (R338W) identified in a subject with pituitary resistance to thyroid hormone.
Molecular and cellular endocrinology 1995;113(1):109-17.
1995: Yoshibayashi M; Kamiya T; Saito Y; Nakao K; Nishioka K; Temma S; Itoh H; Shirakami G; Matsuo H
Plasma brain natriuretic peptide concentrations in healthy children from birth to adolescence: marked and rapid increase after birth.
European journal of endocrinology / European Federation of Endocrine Societies 1995;133(2):207-9.
1995: Komeda T; Fukuda Y; Sando T; Kita R; Furukawa M; Nishida N; Amenomori M; Nakao K
Sensitive detection of circulating hepatocellular carcinoma cells in peripheral venous blood.
Cancer 1995;75(9):2214-9.
1995: Sumida H; Yasue H; Yoshimura M; Okumura K; Ogawa H; Kugiyama K; Matsuyama K; Kikuta K; Morita E; Nakao K
Comparison of secretion pattern between A-type and B-type natriuretic peptides in patients with old myocardial infarction.
Journal of the American College of Cardiology 1995;25(5):1105-10.
1995: Ota H; Kumagai S; Morinobu A; Yanagida H; Nakao K
Enhanced production of transforming growth factor-beta (TGF-beta) during autologous mixed lymphocyte reaction of systemic sclerosis patients.
Clinical and experimental immunology 1995;100(1):99-103.
1995: Tsuyuoka R; Takahashi T; Sasaki Y; Nakamura K; Fukumoto M; Kurisu Y; Tsubakimori K; Shioi K; Nakao K
Long term complete remission in primary plasma cell leukemia.
Internal medicine (Tokyo, Japan) 1995;34(4):251-4.
1995: Ozaki S; Okazaki T; Nakao K
Biological response modifiers (BRM) as antigens. III. T cell lines specific for BRM kill tumor cells in a BRM-specific manner.
Cancer immunology, immunotherapy : CII 1995;40(4):219-27.
1995: Shirakami G; Magaribuchi T; Shingu K; Saito Y; O'higashi T; Nakao K; Mori K
Effects of anesthesia and surgery on plasma endothelin levels.
Anesthesia and analgesia 1995;80(3):449-53.
1995: Fujimoto K; Yasue H; Hashida S; Nakao K; Ishikawa E; Miyamoto E
Augmented expression of atrial myosin light chain 1 in ventricular aneurysms of human: enzyme immunoassay for atrial myosin light chain 1.
Biochemical and biophysical research communications 1995;207(1):75-9.
1995: Ogawa Y; Itoh H; Nakao K
Molecular biology and biochemistry of natriuretic peptide family.
Clinical and experimental pharmacology & physiology 1995;22(1):49-53.
1995: Tsuyuoka R; Takahashi T; Suzuki A; Sasaki Y; Nakamura K; Fukumoto M; Ohmori K; Ohno Y; Nakao K
A newly established megakaryoblastic/erythroid cell line that differentiates to red cells in the presence of erythropoietin and produces platelet-like particles.
Stem cells (Dayton, Ohio) 1995;13(1):54-64.
1995: Hasegawa M; Sagawa N; Itoh H; Inamori K; Mori T; Yano J; Ogawa Y; Yoshimasa T; Nakao K
Endothelin receptors in the human amnion, chorion laeve, decidua vera and placenta.
Reproduction, fertility, and development 1995;7(6):1585-9.
1995: Itoh H; Sagawa N; Hasegawa M; Mori T; Suga S; Mukoyama M; Yoshimasa T; Itoh H; Nakao K
Umbilical venous guanosine 3',5'-cyclic phosphate (cGMP) concentration increases in asphyxiated newborns.
Reproduction, fertility, and development 1995;7(6):1515-9.
1995: Miyamoto Y; Yoshimasa T; Arai H; Takaya K; Ogawa Y; Itoh H; Nakao K
Multiple transcripts of human endothelin-A receptor gene detected by reverse transcription and the polymerase chain reaction.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S29-31.
1995: Yamashita J; Yoshimasa T; Arai H; Hiraoka J; Takaya K; Miyamoto Y; Ogawa Y; Itoh H; Nakao K
Cis elements for transcriptional regulation of the human endothelin-A receptor gene.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S26-8.
1994: Kato H; Yasue H; Yoshimura M; Tanaka H; Miyao Y; Okumura K; Ogawa H; Nakao K
Suppression of hyperventilation-induced attacks with infusion of B-type (brain) natriuretic peptide in patients with variant angina.
American heart journal 1994;128(6 Pt 1):1098-104.
1994: Yasuhara M; Yamaguchi M; Shimizu H; Hashimoto Y; Hama N; Itoh H; Nakao K; Hori R
Natriuretic peptide-potentiating actions of neutral endopeptidase inhibition in rats with experimental heart failure.
Pharmaceutical research 1994;11(12):1726-30.
1994: Yoshimura M; Yasue H; Tanaka H; Kikuta K; Sumida H; Kato H; Jougasaki M; Nakao K
Responses of plasma concentrations of A type natriuretic peptide and B type natriuretic peptide to alacepril, an angiotensin-converting enzyme inhibitor, in patients with congestive heart failure.
British heart journal 1994;72(6):528-33.
1994: Sasaki Y; Usui T; Tanaka I; Nakagawa O; Sando T; Takahashi T; Namba T; Narumiya S; Nakao K
Cloning and expression of a cDNA for rat prostacyclin receptor.
Biochimica et biophysica acta 1994;1224(3):601-5.
1994: Furuto-Kato S; Shimatsu A; Kuzuya H; Matsuda K; Nakao K; Imura H
Insulin sensitivity and glycemic control before and after parathyroidectomy in a diabetic patient with familial multiple endocrine neoplasia type 1.
Endocrine journal 1994;41(6):731-5.
1994: Kishimoto I; Yoshimasa T; Suga S; Ogawa Y; Komatsu Y; Nakagawa O; Itoh H; Nakao K
Natriuretic peptide clearance receptor is transcriptionally down-regulated by beta 2-adrenergic stimulation in vascular smooth muscle cells.
The Journal of biological chemistry 1994;269(45):28300-8.
1994: Ogawa Y; Itoh H; Yoshitake Y; Inoue M; Yoshimasa T; Serikawa T; Nakao K
Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC).
Genomics 1994;24(2):383-7.
1994: Kono S; Kuzuya H; Yamada K; Yoshimasa Y; Okamoto M; Inoue G; Hayashi T; Suga J; Imura H; Nakao K
A novel substrate for insulin-sensitive serine/threonine kinase in intact cells.
Endocrinology 1994;135(4):1529-36.
1994: Nakagawa O; Tanaka I; Usui T; Harada M; Sasaki Y; Itoh H; Yoshimasa T; Namba T; Narumiya S; Nakao K
Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.
Circulation 1994;90(4):1643-7.
1994: Sagawa N; Hasegawa M; Itoh H; Nanno H; Mori T; Yano J; Yoshimasa T; Nakao K
Current topic: the role of amniotic endothelin in human pregnancy.
Placenta 1994;15(6):565-75.
1994: Nakao K; Yasue H
[Clinical characteristics of patients with multivessel coronary artery spasm]
Nippon rinsho. Japanese journal of clinical medicine 1994;52 Suppl(Pt 2):274-9.
1994: Hashimoto Y; Ozaki J; Yasuhara M; Hori R; Suga S; Itoh H; Nakao K; Inui K
Functional evidence for an apical ANP receptor in LLC-PK1 kidney epithelial cells.
European journal of pharmacology 1994;268(3):443-5.
1994: Gondo Y; Nakamura K; Nakao K; Sasaoka T; Ito K; Kimura M; Katsuki M
Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination.
Biochemical and biophysical research communications 1994;202(2):830-7.
1994: Yasue H; Yoshimura M; Sumida H; Kikuta K; Kugiyama K; Jougasaki M; Ogawa H; Okumura K; Mukoyama M; Nakao K
Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure.
Circulation 1994;90(1):195-203.
1994: Shirakami G; Shingu K; Tamai S; Ando A; Suga S; Nakao K; Mori K
A case of "stunned myocardium" after noncardiac surgery: increased concentration of plasma brain natriuretic peptide.
Anesthesia and analgesia 1994;79(1):175-9.
1994: Shirakami G; Magaribuchi T; Shingu K; Kim S; Saito Y; Nakao K; Mori K
Changes of endothelin concentration in cerebrospinal fluid and plasma of patients with aneurysmal subarachnoid hemorrhage.
Acta anaesthesiologica Scandinavica 1994;38(5):457-61.
1994: Miyoshi Y; Nakamura H; Tagami T; Sasaki S; Nakao K
3,5,3'-Triiodothyronine stimulates retinoic acid-induced differentiation in HL-60 cells.
Molecular and cellular endocrinology 1994;103(1-2):119-23.
1994: Nishida N; Fukuda Y; Komeda T; Kita R; Sando T; Furukawa M; Amenomori M; Shibagaki I; Nakao K; Ikenaga M
Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma.
Cancer research 1994;54(12):3107-10.
1994: Hama N; Itoh H; Suga S; Komatsu Y; Yoshimasa T; Nakao K
A monoclonal antibody to C-type natriuretic peptide--preparation and application to radioimmunoassay and neutralization experiment.
The Journal of endocrinology 1994;141(3):473-9.
1994: Masuzaki H; Jingami H; Yamamoto T; Nakao K
Effects of estradiol on very low density lipoprotein receptor mRNA levels in rabbit heart.
FEBS letters 1994;347(2-3):211-4.
1994: Ogawa Y; Itoh H; Tamura N; Suga S; Yoshimasa T; Uehira M; Matsuda S; Shiono S; Nishimoto H; Nakao K
Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene.
The Journal of clinical investigation 1994;93(5):1911-21.
1994: Kita M; Taii S; Kataoka N; Shimatsu A; Nakao K; Mori T
Changes of gonadotrophin surge inhibiting/attenuating factor activity in pig follicular fluid in relation to follicle size.
Journal of reproduction and fertility 1994;101(1):59-66.
1994: Sakamoto A; Yanagisawa M; Tsujimoto G; Nakao K; Toyo-oka T; Masaki T
Pseudo-noncompetitive antagonism by BQ123 of intracellular calcium transients mediated by human ETA endothelin receptor.
Biochemical and biophysical research communications 1994;200(2):679-86.
1994: Yoshimura T; Yoshimura M; Yasue H; Ito M; Okamura H; Mukoyama M; Nakao K
Plasma concentration of atrial natriuretic peptide and brain natriuretic peptide during normal human pregnancy and the postpartum period.
The Journal of endocrinology 1994;140(3):393-7.
1994: Hasegawa K; Fujiwara H; Doyama K; Inada T; Ohtani S; Fujiwara T; Hosoda K; Nakao K; Sasayama S
Endothelin-1-selective receptor in the arterial intima of patients with hypertension.
Hypertension 1994;23(3):288-93.
1994: Hama N; Itoh H; Shirakami G; Suga S; Komatsu Y; Yoshimasa T; Tanaka I; Mori K; Nakao K
Detection of C-type natriuretic peptide in human circulation and marked increase of plasma CNP level in septic shock patients.
Biochemical and biophysical research communications 1994;198(3):1177-82.
1994: Hashimoto Y; Nakao K; Hama N; Imura H; Mori S; Yamaguchi M; Yasuhara M; Hori R
Clearance mechanisms of atrial and brain natriuretic peptides in rats.
Pharmaceutical research 1994;11(1):60-4.
1994: Itoh H; Nakao K
Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling.
Blood pressure. Supplement 1994;5():49-53.
1994: Tsuyuoka R; Takahashi T; Sasaki Y; Taniguchi Y; Fukumoto M; Suzuki A; Nakamura K; Kobayashi S; Kudo T; Nakao K
Colony-stimulating factor-producing tumours: production of granulocyte colony-stimulating factor and interleukin-6 is secondary to interleukin-1 production.
European journal of cancer (Oxford, England : 1990) 1994;30A(14):2130-6.
1993: Shirakami G; Magaribuchi T; Shingu K; Suga S; Tamai S; Nakao K; Mori K
Positive end-expiratory pressure ventilation decreases plasma atrial and brain natriuretic peptide levels in humans.
Anesthesia and analgesia 1993;77(6):1116-21.
1993: Suga S; Itoh H; Komatsu Y; Ogawa Y; Hama N; Yoshimasa T; Nakao K
Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells--evidence for CNP as a novel autocrine/paracrine regulator from endothelial cells.
Endocrinology 1993;133(6):3038-41.
1993: Muramami N; Fukata J; Tsukada T; Kobayashi H; Ebisui O; Segawa H; Muro S; Imura H; Nakao K
Bacterial lipopolysaccharide-induced expression of interleukin-6 messenger ribonucleic acid in the rat hypothalamus, pituitary, adrenal gland, and spleen.
Endocrinology 1993;133(6):2574-8.
1993: Kishimoto I; Nakao K; Suga S; Hosoda K; Yoshimasa T; Itoh H; Imura H
Downregulation of C-receptor by natriuretic peptides via ANP-B receptor in vascular smooth muscle cells.
The American journal of physiology 1993;265(4 Pt 2):H1373-9.
1993: Kono S; Kuzuya H; Yamada K; Yoshimasa Y; Okamoto M; Inoue G; Hayashi T; Nakao K; Imura H
Anti-phosphoserine and anti-phosphothreonine antibodies modulate autophosphorylation of the insulin receptor but not EGF receptor.
Biochemical and biophysical research communications 1993;196(1):216-22.
1993: Shimatsu A; Nakao K
[Alterations in receptor status and signal transduction mechanisms in pituitary tumors]
Nippon rinsho. Japanese journal of clinical medicine 1993;51(10):2754-8.
1993: Imura H; Nakao K; Shimatsu A; Ogawa Y; Sando T; Fujisawa I; Yamabe H
Lymphocytic infundibuloneurohypophysitis as a cause of central diabetes insipidus.
The New England journal of medicine 1993;329(10):683-9.
1993: Nakaishi S; Nakai Y; Fukata J; Naito Y; Usui T; Fukushima M; Jingami H; Nakao K; Imura H
Immunoreactive corticotropin-releasing hormone levels in discrete hypothalamic nuclei of genetically obese Zucker rats.
Neuroscience letters 1993;159(1-2):29-31.
1993: Shirakami G; Itoh H; Suga S; Komatsu Y; Hama N; Mori K; Nakao K
Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats.
Neuroscience letters 1993;159(1-2):25-8.
1993: Kumagai N; Morii N; Fujisawa K; Yoshimasa T; Nakao K; Narumiya S
Lysophosphatidic acid induces tyrosine phosphorylation and activation of MAP-kinase and focal adhesion kinase in cultured Swiss 3T3 cells.
FEBS letters 1993;329(3):273-6.
1993: Hasegawa K; Fujiwara H; Doyama K; Miyamae M; Fujiwara T; Suga S; Mukoyama M; Nakao K; Imura H; Sasayama S
Ventricular expression of brain natriuretic peptide in hypertrophic cardiomyopathy.
Circulation 1993;88(2):372-80.
1993: Tanaka H; Yasue H; Yoshimura M; Morita E; Jougasaki M; Kato H; Miyao Y; Nakao K
Suppression of hyperventilation-induced attacks with infusion of atrial natriuretic peptide in patients with variant angina pectoris.
The American journal of cardiology 1993;72(2):128-33.
1993: Morita E; Yasue H; Yoshimura M; Ogawa H; Jougasaki M; Matsumura T; Mukoyama M; Nakao K
Increased plasma levels of brain natriuretic peptide in patients with acute myocardial infarction.
Circulation 1993;88(1):82-91.
1993: Arai H; Hosoda K; Shirakami G; Yoshimasa T; Nakao K
[Molecular biology of endothelins and endothelin receptors]
Nippon rinsho. Japanese journal of clinical medicine 1993;51(6):1530-9.
1993: Hashimoto Y; Mori S; Hama N; Nakao K; Imura H; Yamaguchi M; Yasuhara M; Hori R
Nonlinear mixed effect modeling of the pharmacodynamics of natriuretic peptides in rats.
Journal of pharmacokinetics and biopharmaceutics 1993;21(3):281-97.
1993: Itoh H; Suga S; Ogawa Y; Tanaka I; Nakao K
[Molecular biology and pharmacology of natriuretic peptide system]
Nippon rinsho. Japanese journal of clinical medicine 1993;51(6):1548-56.
1993: Shirakami G; Nakao K; Saito Y; Magaribuchi T; Mukoyama M; Arai H; Hosoda K; Suga S; Mori K; Imura H
Low doses of endothelin-1 inhibit atrial natriuretic peptide secretion.
Endocrinology 1993;132(5):1905-12.
1993: Sakamoto A; Yanagisawa M; Sawamura T; Enoki T; Ohtani T; Sakurai T; Nakao K; Toyo-oka T; Masaki T
Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.
The Journal of biological chemistry 1993;268(12):8547-53.
1993: Arai H; Nakao K; Takaya K; Hosoda K; Ogawa Y; Nakanishi S; Imura H
The human endothelin-B receptor gene. Structural organization and chromosomal assignment.
The Journal of biological chemistry 1993;268(5):3463-70.
1993: Yoshimura M; Yasue H; Okumura K; Ogawa H; Jougasaki M; Mukoyama M; Nakao K; Imura H
Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure.
Circulation 1993;87(2):464-9.
1993: Hasegawa K; Fujiwara H; Doyama K; Mukoyama M; Nakao K; Fujiwara T; Imura H; Kawai C
Ventricular expression of atrial and brain natriuretic peptides in dilated cardiomyopathy. An immunohistocytochemical study of the endomyocardial biopsy specimens using specific monoclonal antibodies.
The American journal of pathology 1993;142(1):107-16.
1993: Fujimoto K; Yasue H; Nakao K; Yamamoto H; Hitoshi Y; Jougasaki M; Okumura K; Ogawa H; Takatsu K; Miyamoto E
Novel monoclonal antibodies specific for human cardiac myosin light-chain 1: useful tools for analysis of normal and pathological hearts.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1993;41(1):35-42.
1993: Nakao K; Itoh H; Suga S; Ogawa Y; Imura H
The natriuretic peptide family.
Current opinion in nephrology and hypertension 1993;2(1):45-50.
1993: Sakamoto A; Yanagisawa M; Sakurai T; Nakao K; Toyo-oka T; Yano M; Masaki T
The ligand-receptor interactions of the endothelin systems are mediated by distinct "message" and "address" domains.
Journal of cardiovascular pharmacology 1993;22 Suppl 8():S113-6.
1992: Ogawa Y; Nakao K; Itoh H; Suga S; Imura H
[Molecular biology of the natriuretic peptide system]
Nippon rinsho. Japanese journal of clinical medicine 1992;50(12):2885-92.
1992: Nakao K; Yasue H; Fujimoto K; Jougasaki M; Yamamoto H; Hitoshi Y; Takatsu K; Miyamoto E
Increased expression and regional differences of atrial myosin light chain 1 in human ventricles with old myocardial infarction. Analyses using two monoclonal antibodies.
Circulation 1992;86(6):1727-37.
1992: Itoh H; Sagawa N; Ihara Y; Hasegawa M; Okagaki A; Inamori K; Mori T; Mukoyama M; Suga S; Nakao K
[The elevated level of brain natriuretic peptide (BNP) in the umbilical cord plasma under with fetal distress]
Nippon Sanka Fujinka Gakkai zasshi 1992;44(10):1279-80.
1992: Yoshimasa T; Nakao K; Suga S; Kishimoto I; Kiso Y; Imura H
Identification and endothelin-induced activation of multiple extracellular signal-regulated kinases in aortic smooth muscle cells.
FEBS letters 1992;311(3):195-8.
1992: Nakao K; Ogawa Y; Suga S; Imura H
Molecular biology and biochemistry of the natriuretic peptide system. II: Natriuretic peptide receptors.
Journal of hypertension 1992;10(10):1111-4.
1992: Suga S; Nakao K; Itoh H; Komatsu Y; Ogawa Y; Hama N; Imura H
Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta. Possible existence of "vascular natriuretic peptide system".
The Journal of clinical investigation 1992;90(3):1145-9.
1992: Jougasaki M; Kugiyama K; Saito Y; Nakao K; Imura H; Yasue H
Suppression of endothelin-1 secretion by lysophosphatidylcholine in oxidized low density lipoprotein in cultured vascular endothelial cells.
Circulation research 1992;71(3):614-9.
1992: Nakao K; Yasue H; Fujimoto K; Okumura K; Yamamoto H; Hitoshi Y; Murohara T; Takatsu K; Miyamoto E
Increased expression of atrial myosin light chain 1 in the overloaded human left ventricle: possible expression of fetal type myocytes.
International journal of cardiology 1992;36(3):315-28.
1992: Nakao K; Ogawa Y; Suga S; Imura H
Molecular biology and biochemistry of the natriuretic peptide system. I: Natriuretic peptides.
Journal of hypertension 1992;10(9):907-12.
1992: Hosoda K; Nakao K; Tamura N; Arai H; Ogawa Y; Suga S; Nakanishi S; Imura H
Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor.
The Journal of biological chemistry 1992;267(26):18797-804.
1992: Imura H; Nakao K; Itoh H
The natriuretic peptide system in the brain: implications in the central control of cardiovascular and neuroendocrine functions.
Frontiers in neuroendocrinology 1992;13(3):217-49.
1992: Suga S; Nakao K; Kishimoto I; Hosoda K; Mukoyama M; Arai H; Shirakami G; Ogawa Y; Komatsu Y; Nakagawa O
Phenotype-related alteration in expression of natriuretic peptide receptors in aortic smooth muscle cells.
Circulation research 1992;71(1):34-9.
1992: Hashimoto Y; Nakao K; Hama N; Mukoyama M; Imura H; Yasuhara M; Hori R
Pharmacokinetics of brain natriuretic peptide in rats.
Chemical & pharmaceutical bulletin 1992;40(6):1650-2.
1992: Suga S; Nakao K; Mukoyama M; Arai H; Hosoda K; Ogawa Y; Imura H
Characterization of natriuretic peptide receptors in cultured cells.
Hypertension 1992;19(6 Pt 2):762-5.
1992: Ogawa Y; Nakao K; Nakagawa O; Komatsu Y; Hosoda K; Suga S; Arai H; Nagata K; Yoshida N; Imura H
Human C-type natriuretic peptide. Characterization of the gene and peptide.
Hypertension 1992;19(6 Pt 2):809-13.
1992: Ogawa Y; Nakao K; Imura H
[Molecular biology of the natriuretic peptide family]
Nippon rinsho. Japanese journal of clinical medicine 1992;50 Suppl():46-53.
1992: Itoh H; Nakao K; Suga S; Imura H
[Pharmacology and action mechanism of natriuretic peptide family as a regulator of blood pressure]
Nippon rinsho. Japanese journal of clinical medicine 1992;50 Suppl():124-33.
1992: Nakao K
[Natriuretic peptide family]
Nippon Naibunpi Gakkai zasshi 1992;68(3):134-42.
1992: Murakami N; Fukata J; Usui T; Naito Y; Tominaga T; Nakai Y; Masui Y; Nakao K; Imura H
Effects of repetitive administration of recombinant human interleukin-1 beta, an analog or corticotropin-releasing hormone combined with lysine vasopressin on rats with glucocorticoid-induced secondary adrenocortical insufficiency.
The Journal of pharmacology and experimental therapeutics 1992;260(3):1344-8.
1992: Itoh H; Sagawa N; Ihara Y; Hasegawa M; Okagaki A; Inamori K; Mori T; Suga S; Mukoyama M; Nakao K
[Plasma levels of brain natriuretic peptide (BNP) in the women with severe pregnancy-induced hypertension]
Nippon Sanka Fujinka Gakkai zasshi 1992;44(2):237-8.
1992: Suga S; Nakao K; Hosoda K; Mukoyama M; Ogawa Y; Shirakami G; Arai H; Saito Y; Kambayashi Y; Inouye K
Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide.
Endocrinology 1992;130(1):229-39.
1992: Kario K; Matsuo T; Nakao K
Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis.
Clinical and laboratory haematology 1992;14(4):281-7.
1992: Arai H; Nakao K; Hosoda K; Ogawa Y; Nakagawa O; Komatsu Y; Imura H
[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]
Japanese circulation journal 1992;56 Suppl 5():1303-7.
1991: Yoshibayashi M; Nishioka K; Nakao K; Saito Y; Matsumura M; Ueda T; Temma S; Shirakami G; Imura H; Mikawa H
Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Evidence for increased production of endothelin in pulmonary circulation.
Circulation 1991;84(6):2280-5.
1991: Matsuyama K; Yasue H; Okumura K; Saito Y; Nakao K; Shirakami G; Imura H
Increased plasma level of endothelin-1-like immunoreactivity during coronary spasm in patients with coronary spastic angina.
The American journal of cardiology 1991;68(10):991-5.
1991: Yoshimura M; Yasue H; Morita E; Sakaino N; Jougasaki M; Kurose M; Mukoyama M; Saito Y; Nakao K; Imura H
Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure.
Circulation 1991;84(4):1581-8.
1991: Mukoyama M; Nakao K; Obata K; Jougasaki M; Yoshimura M; Morita E; Hosoda K; Suga S; Ogawa Y; Yasue H
Augmented secretion of brain natriuretic peptide in acute myocardial infarction.
Biochemical and biophysical research communications 1991;180(1):431-6.
1991: Nakao K; Mukoyama M; Hosoda K; Suga S; Ogawa Y; Saito Y; Shirakami G; Arai H; Jougasaki M; Imura H
Biosynthesis, secretion, and receptor selectivity of human brain natriuretic peptide.
Canadian journal of physiology and pharmacology 1991;69(10):1500-6.
1991: Iwai M; Hasegawa M; Taii S; Sagawa N; Nakao K; Imura H; Nakanishi S; Mori T
Endothelins inhibit luteinization of cultured porcine granulosa cells.
Endocrinology 1991;129(4):1909-14.
1991: Hasegawa K; Fujiwara H; Itoh H; Nakao K; Fujiwara T; Imura H; Kawai C
Light and electron microscopic localization of brain natriuretic peptide in relation to atrial natriuretic peptide in porcine atrium. Immunohistocytochemical study using specific monoclonal antibodies.
Circulation 1991;84(3):1203-9.
1991: Komatsu Y; Nakao K; Suga S; Ogawa Y; Mukoyama M; Arai H; Shirakami G; Hosoda K; Nakagawa O; Hama N
C-type natriuretic peptide (CNP) in rats and humans.
Endocrinology 1991;129(2):1104-6.
1991: Ogawa Y; Nakao K; Mukoyama M; Hosoda K; Shirakami G; Arai H; Saito Y; Suga S; Jougasaki M; Imura H
Natriuretic peptides as cardiac hormones in normotensive and spontaneously hypertensive rats. The ventricle is a major site of synthesis and secretion of brain natriuretic peptide.
Circulation research 1991;69(2):491-500.
1991: Hosoda K; Nakao K; Hiroshi-Arai; Suga S; Ogawa Y; Mukoyama M; Shirakami G; Saito Y; Nakanishi S; Imura H
Cloning and expression of human endothelin-1 receptor cDNA.
FEBS letters 1991;287(1-2):23-6.
1991: Ogawa Y; Nakao K; Arai H; Nakagawa O; Hosoda K; Suga S; Nakanishi S; Imura H
Molecular cloning of a non-isopeptide-selective human endothelin receptor.
Biochemical and biophysical research communications 1991;178(1):248-55.
1991: Hosoda K; Nakao K; Mukoyama M; Saito Y; Jougasaki M; Shirakami G; Suga S; Ogawa Y; Yasue H; Imura H
Expression of brain natriuretic peptide gene in human heart. Production in the ventricle.
Hypertension 1991;17(6 Pt 2):1152-5.
1991: Mukoyama M; Nakao K; Hosoda K; Suga S; Saito Y; Ogawa Y; Shirakami G; Jougasaki M; Obata K; Yasue H
Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.
The Journal of clinical investigation 1991;87(4):1402-12.
1991: Nishimura K; Saito Y; Hidaka T; Ishihara T; Nakao K; Imura H; Okamoto Y; Ban T
Does atrial appendectomy aggravate secretory function of atrial natriuretic polypeptide?
The Journal of thoracic and cardiovascular surgery 1991;101(3):502-8.
1991: Takemura G; Fujiwara H; Mukoyama M; Saito Y; Nakao K; Kawamura A; Ishida M; Kida M; Uegaito T; Tanaka M
Expression and distribution of atrial natriuretic peptide in human hypertrophic ventricle of hypertensive hearts and hearts with hypertrophic cardiomyopathy.
Circulation 1991;83(1):181-90.
1991: Itoh H; Nakao K; Mukoyama M; Arai H; Yamada T; Saito Y; Shiono S; Hosoda K; Shirakami G; Suga S
Pathophysiological role of augmented atrial natriuretic polypeptide gene expression in DOCA-salt hypertension. Effects of atrial natriuretic polypeptide monoclonal antibody.
American journal of hypertension 1991;4(1 Pt 1):39-44.
1991: Takemura G; Fujiwara H; Horike K; Kawai C; Mukoyama M; Saito Y; Nakao K; Imura H; Fujiwara T
[Expression of atrial natriuretic polypeptide in ventricles of heart with hypertrophic cardiomyopathy: an immunohistochemical study of endomyocardial specimens]
Journal of cardiology 1991;21(3):641-7.
1991: Shirakami G; Nakao K; Saito Y; Magaribuchi T; Jougasaki M; Mukoyama M; Arai H; Hosoda K; Suga S; Ogawa Y
Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats.
Life sciences 1991;48(10):969-76.
1991: Yoshibayashi M; Nishioka K; Nakao K; Saito Y; Temma S; Matsumura M; Ueda T; Shirakami G; Imura H; Mikawa H
Plasma endothelin levels in healthy children: high values in early infancy.
Journal of cardiovascular pharmacology 1991;17 Suppl 7():S404-5.
1991: Nakagawa O; Nakao K; Saito Y; Shirakami G; Jougasaki M; Mukoyama M; Hosoda K; Suga S; Ogawa Y; Kishimoto I
Isolation and characterization of porcine endothelin-like peptide.
Journal of cardiovascular pharmacology 1991;17 Suppl 7():S13-6.
1990: Itoh H; Nakao K; Mukoyama M; Saito Y; Yamada T; Shirakami G; Arai H; Hosoda K; Suga S; Yoshida I
Preparation of monoclonal antibodies against brain natriuretic peptide and their application to radioimmunoassay and passive immunization.
Endocrinology 1990;127(3):1292-300.
1990: Mukoyama M; Nakao K; Saito Y; Ogawa Y; Hosoda K; Suga S; Shirakami G; Jougasaki M; Imura H
Increased human brain natriuretic peptide in congestive heart failure.
The New England journal of medicine 1990;323(11):757-8.
1990: Takemura G; Fujiwara H; Yoshida H; Mukoyama M; Saito Y; Nakao K; Fujiwara T; Uegaito T; Imura H; Kawai C
Identification and distribution of atrial natriuretic polypeptide in ventricular myocardium of humans with myocardial infarction.
The Journal of pathology 1990;161(4):285-92.
1990: Nakao K; Itoh H; Kambayashi Y; Hosoda K; Saito Y; Yamada T; Mukoyama M; Arai H; Shirakami G; Suga S
Rat brain natriuretic peptide. Isolation from rat heart and tissue distribution.
Hypertension 1990;15(6 Pt 2):774-8.
1990: Saito Y; Nakao K; Mukoyama M; Shirakami G; Itoh H; Yamada T; Arai H; Hosoda K; Suga S; Jougasaki M
Application of monoclonal antibodies for endothelin to hypertensive research.
Hypertension 1990;15(6 Pt 2):734-8.
1990: Obata K; Yasue H; Okumura K; Matsuyama K; Ogawa H; Kurose M; Saito Y; Nakao K; Imura H; Nobuyoshi M
Atrial natriuretic polypeptide is removed by the lungs and released into the left atrium as well as the right atrium in humans.
Journal of the American College of Cardiology 1990;15(7):1537-43.
1990: Yamada T; Nakao K; Shirakami G; Saito Y; Mukoyama M; Arai H; Hosoda K; Suga S; Jogasaki M; Ogawa Y
[Nerve tissue distribution and physiologic role of endogenous opioid peptides and their receptors--POMC-, proenkephalin A, proenkephalin B- derived opioid peptides and kyotorphin]
Nippon rinsho. Japanese journal of clinical medicine 1990;48(5):1042-52.
1990: Ogawa Y; Nakao K; Mukoyama M; Shirakami G; Itoh H; Hosoda K; Saito Y; Arai H; Suga S; Jougasaki M
Rat brain natriuretic peptide--tissue distribution and molecular form.
Endocrinology 1990;126(4):2225-7.
1990: Inoue Y; Oike M; Nakao K; Kitamura K; Kuriyama H
Endothelin augments unitary calcium channel currents on the smooth muscle cell membrane of guinea-pig portal vein.
The Journal of physiology 1990;423():171-91.
1990: Inoue Y; Nakao K; Okabe K; Izumi H; Kanda S; Kitamura K; Kuriyama H
Some electrical properties of human pregnant myometrium.
American journal of obstetrics and gynecology 1990;162(4):1090-8.
1990: Okazawa H; Endo K; Saga T; Watanabe Y; Nakai T; Kasagi K; Konishi J; Abe M; Goto K; Nakao K
[Therapy of malignant pheochromocytoma using I-131 metaiodobenzylguanidine--report of a case]
Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica 1990;50(3):286-94.
1990: Nakao K; Inoue Y; Oike M; Kitamura K; Kuriyama H
Mechanisms of endothelin-induced augmentation of the electrical and mechanical activity in rat portal vein.
Pflügers Archiv : European journal of physiology 1990;415(5):526-32.
1990: Okabe K; Kajioka S; Nakao K; Kitamura K; Kuriyama H; Weston A H
Actions of cromakalim on ionic currents recorded from single smooth muscle cells of the rat portal vein.
The Journal of pharmacology and experimental therapeutics 1990;252(2):832-9.
1990: Jougasaki M; Yasue H; Mukoyama M; Nakao K; Takahashi K
Appearance of atrial natriuretic peptide in the ventricles in patients with myocardial infarction.
American heart journal 1990;119(1):92-6.
1990: Nishimura K; Ban T; Saito Y; Nakao K; Imura H
Atrial pacing stimulates secretion of atrial natriuretic polypeptide without elevation of atrial pressure in awake dogs with experimental complete atrioventricular block.
Circulation research 1990;66(1):115-22.
1990: Kambayashi Y; Nakao K; Mukoyama M; Saito Y; Ogawa Y; Shiono S; Inouye K; Yoshida N; Imura H
Isolation and sequence determination of human brain natriuretic peptide in human atrium.
FEBS letters 1990;259(2):341-5.
1989: Takemura G; Fujiwara H; Horike K; Mukoyama M; Saito Y; Nakao K; Matsuda M; Kawamura A; Ishida M; Kida M
Ventricular expression of atrial natriuretic polypeptide and its relations with hemodynamics and histology in dilated human hearts. Immunohistochemical study of the endomyocardial biopsy specimens.
Circulation 1989;80(5):1137-47.
1989: Nishiye E; Nakao K; Kitamura K; Kuriyama H
Inhibitory actions of a novel benzothiazepine derivative, TA3090, on the electrical and mechanical responses of the rabbit mesenteric artery.
The Journal of pharmacology and experimental therapeutics 1989;250(3):1079-86.
1989: Saito Y; Nakao K; Shirakami G; Jougasaki M; Yamada T; Itoh H; Mukoyama M; Arai H; Hosoda K; Suga S
Detection and characterization of endothelin-1-like immunoreactivity in rat plasma.
Biochemical and biophysical research communications 1989;163(3):1512-6.
1989: Obata K; Yasue H; Okumura K; Matsuyama K; Ogawa H; Kurose M; Nakao K; Imura H
Increased secretion of atrial natriuretic polypeptide in response to cardiac pacing.
Japanese circulation journal 1989;53(9):1055-60.
1989: Nakao K; Itoh H; Saito Y; Yamada T; Mukoyama M; Arai H; Hosoda K; Shirakami G; Suga S; Jougasaki M
[A family of natriuretic peptides (ANP.BNP)]
Nippon rinsho. Japanese journal of clinical medicine 1989;47(9):1987-95.
1989: Yamada T; Nakao K; Itoh H; Shirakami G; Sugawara A; Saito Y; Mukoyama M; Arai H; Hosoda K; Shiono S
Effects of naloxone on vasopressin secretion in conscious rats: evidence for inhibitory role of endogenous opioid peptides in vasopressin secretion.
Endocrinology 1989;125(2):785-90.
1989: Kambayashi Y; Nakao K; Itoh H; Hosoda K; Saito Y; Yamada T; Mukoyama M; Arai H; Shirakami G; Suga S
Isolation and sequence determination of rat cardiac natriuretic peptide.
Biochemical and biophysical research communications 1989;163(1):233-40.
1989: Itoh H; Nakao K; Mukoyama M; Yamada T; Hosoda K; Shirakami G; Morii N; Sugawara A; Saito Y; Shiono S
Chronic blockade of endogenous atrial natriuretic polypeptide (ANP) by monoclonal antibody against ANP accelerates the development of hypertension in spontaneously hypertensive and deoxycorticosterone acetate-salt-hypertensive rats.
The Journal of clinical investigation 1989;84(1):145-54.
1989: Takemura G; Fujiwara H; Mukoyama M; Saito Y; Matsuda M; Kawamura A; Ishida M; Kida M; Uegaito T; Nakao K
Immunohistochemical localization and semi-quantification of atrial natriuretic polypeptide (ANP) in formalin-fixed-paraffin-embedded normal human hearts--comparative study with radioimmunoassay.
Japanese circulation journal 1989;53(7):686-94.
1989: Itoh H; Nakao K; Kambayashi Y; Hosoda K; Saito Y; Yamada T; Mukoyama M; Arai H; Shirakami G; Suga S
Occurrence of a novel cardiac natriuretic peptide in rats.
Biochemical and biophysical research communications 1989;161(2):732-9.
1989: Fujisawa I; Asato R; Kawata M; Sano Y; Nakao K; Yamada T; Imura H; Naito Y; Hoshino K; Noma S
Hyperintense signal of the posterior pituitary on T1-weighted MR images: an experimental study.
Journal of computer assisted tomography 1989;13(3):371-7.
1989: Saito Y; Nakao K; Itoh H; Yamada T; Mukoyama M; Arai H; Hosoda K; Shirakami G; Suga S; Jougasaki M
Endothelin in human plasma and culture medium of aortic endothelial cells--detection and characterization with radioimmunoassay using monoclonal antibody.
Biochemical and biophysical research communications 1989;161(1):320-6.
1989: Nishiye E; Nakao K; Itoh T; Kuriyama H
Factors inducing endothelium-dependent relaxation in the guinea-pig basilar artery as estimated from the actions of haemoglobin.
British journal of pharmacology 1989;96(3):645-55.
1989: Nakao K; Kitamura K; Kuriyama H
Prostaglandins augment muscarinic responses in the rabbit cecum.
The American journal of physiology 1989;256(1 Pt 1):G100-6.
1989: Iwata T; Inui K; Nakao K; Imura H; Matsuo H; Hori R
Effect of brain natriuretic peptide on cyclic GMP accumulation in a kidney epithelial cell line (LLC-PK1).
European journal of pharmacology 1989;159(3):321-3.
1989: Saito Y; Nakao K; Itoh H; Yamada T; Mukoyama M; Arai H; Hosoda K; Shirakami G; Suga S; Minamino N
Brain natriuretic peptide is a novel cardiac hormone.
Biochemical and biophysical research communications 1989;158(2):360-8.
1989: Itoh H; Nakao K; Saito Y; Yamada T; Shirakami G; Mukoyama M; Arai H; Hosoda K; Suga S; Minamino N
Radioimmunoassay for brain natriuretic peptide (BNP) detection of BNP in canine brain.
Biochemical and biophysical research communications 1989;158(1):120-8.
1989: Yasue H; Obata K; Okumura K; Kurose M; Ogawa H; Matsuyama K; Jougasaki M; Saito Y; Nakao K; Imura H
Increased secretion of atrial natriuretic polypeptide from the left ventricle in patients with dilated cardiomyopathy.
The Journal of clinical investigation 1989;83(1):46-51.
1989: Saito Y; Nakao K; Arai H; Nishimura K; Okumura K; Obata K; Takemura G; Fujiwara H; Sugawara A; Yamada T
Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart.
The Journal of clinical investigation 1989;83(1):298-305.
1989: Morii N; Nakao K; Matsumori A; Tomioka Y; Kawai C; Imura H
Increased synthesis and secretion of atrial natriuretic polypeptide during viral myocarditis.
Journal of cardiovascular pharmacology 1989;13 Suppl 6():S5-8.
1989: Saito Y; Nakao K; Arai H; Nishimura K; Takemura G; Fujiwara H; Sugawara A; Yamada T; Itoh H; Makoyama M
Relationship between ventricular expression of atrial natriuretic polypeptide gene and hemodynamic parameter in old myocardial infarction.
Journal of cardiovascular pharmacology 1989;13 Suppl 6():S1-4.
1988: Yamada T; Nakao K; Itoh H; Shirakami G; Kangawa K; Minamino N; Matsuo H; Imura H
Intracerebroventricular injection of brain natriuretic peptide inhibits vasopressin secretion in conscious rats.
Neuroscience letters 1988;95(1-3):223-8.
1988: Sugawara A; Nakao K; Itoh H; Yamada T; Saito Y; Mukoyama M; Arai H; Hosoda K; Shirakami G; Morii N
Cosecretion of peptides derived from gamma-human atrial natriuretic polypeptide in normal volunteers and patients with essential hypertension and adrenal disorders.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1988;6(4):S327-9.
1988: Mukoyama M; Nakao K; Yamada T; Itoh H; Hosoda K; Saito Y; Sugawara A; Arai H; Shirakami G; Morii N
Preparation of monoclonal antibodies against atrial natriuretic polypeptide precursor and application to highly sensitive sandwich enzyme immunoassay.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1988;6(4):S320-2.
1988: Itoh H; Nakao K; Mukoyama M; Hosada K; Shiono S; Morii N; Yamada T; Sugawara A; Saito Y; Arai H
Peptides derived from atrial natriuretic polypeptide precursor in human and monkey brains.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1988;6(4):S309-13.
1988: Arai H; Nakao K; Saito Y; Sugawara A; Yamada T; Itoh H; Mukoyama M; Hosoda K; Shirakami G; Morii N
Expression of atrial natriuretic factor gene in hearts from neonates of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1988;6(4):S276-8.
1988: Nakao K; Okabe K; Kitamura K; Kuriyama H; Weston A H
Characteristics of cromakalim-induced relaxations in the smooth muscle cells of guinea-pig mesenteric artery and vein.
British journal of pharmacology 1988;95(3):795-804.
1988: Saito Y; Nakao K; Sugawara A; Nishimura K; Morii N; Yamada T; Itoh H; Shiono S; Mukoyama M; Arai H
Exaggerated secretion of atrial natriuretic polypeptide during dynamic exercise in patients with essential hypertension.
American heart journal 1988;116(4):1052-7.
1988: Morii N; Sekine A; Ohashi Y; Nakao K; Imura H; Fujiwara M; Narumiya S
Purification and properties of the cytosolic substrate for botulinum ADP-ribosyltransferase. Identification as an Mr 22,000 guanine nucleotide-binding protein.
The Journal of biological chemistry 1988;263(25):12420-6.
1988: Itoh H; Nakao K; Sugawara A; Saito Y; Mukoyama M; Morii N; Yamada T; Shiono S; Arai H; Hosoda K
Gamma-atrial natriuretic polypeptide (gamma ANP)-derived peptides in human plasma: cosecretion of N-terminal gamma ANP fragment and alpha ANP.
The Journal of clinical endocrinology and metabolism 1988;67(3):429-37.
1988: Shirakami G; Nakao K; Yamada T; Itoh H; Mori K; Kangawa K; Minamino N; Matsuo H; Imura H
Inhibitory effect of brain natriuretic peptide on central angiotensin II-stimulated pressor response in conscious rats.
Neuroscience letters 1988;91(1):77-83.
1988: Mukoyama M; Nakao K; Sugawa H; Morii N; Sugawara A; Yamada T; Itoh H; Shiono S; Saito Y; Arai H
A monoclonal antibody to alpha-human atrial natriuretic polypeptide.
Hypertension 1988;12(2):117-21.
1988: Itoh H; Nakao K; Yamada T; Morii N; Shiono S; Sakamoto M; Sugawara A; Saito Y; Mukoyama M; Arai H
Potent depressor action of leumorphin, a kappa-opioid agonist, in conscious rats.
American journal of hypertension 1988;1(3 Pt 1):256-61.
1988: Itoh H; Nakao K; Mukoyama M; Shiono S; Morii N; Sugawara A; Yamada T; Saito Y; Arai H; Hosoda K
Effects of intravenously administered beta-human atrial natriuretic polypeptide in humans.
Hypertension 1988;11(6 Pt 2):697-702.
1988: Mukoyama M; Nakao K; Morii N; Shiono S; Itoh H; Sugawara A; Yamada T; Saito Y; Arai H; Imura H
Atrial natriuretic polypeptide in bovine adrenal medulla.
Hypertension 1988;11(6 Pt 2):692-6.
1988: Sugawara A; Nakao K; Morii N; Yamada T; Itoh H; Shiono S; Saito Y; Mukoyama M; Arai H; Nishimura K
Synthesis of atrial natriuretic polypeptide in human failing hearts. Evidence for altered processing of atrial natriuretic polypeptide precursor and augmented synthesis of beta-human ANP.
The Journal of clinical investigation 1988;81(6):1962-70.
1988: Itoh H; Nakao K; Yamada T; Shirakami G; Kangawa K; Minamino N; Matsuo H; Imura H
Antidipsogenic action of a novel peptide, 'brain natriuretic peptide', in rats.
European journal of pharmacology 1988;150(1-2):193-6.
1988: Arai H; Nakao K; Saito Y; Morii N; Sugawara A; Yamada T; Itoh H; Shiono S; Mukoyama M; Ohkubo H
Augmented expression of atrial natriuretic polypeptide gene in ventricles of spontaneously hypertensive rats (SHR) and SHR-stroke prone.
Circulation research 1988;62(5):926-30.
1988: Yamada T; Nakao K; Itoh H; Morii N; Shiono S; Sakamoto M; Sugawara A; Saito Y; Mukoyama M; Arai H
Inhibitory action of leumorphin on vasopressin secretion in conscious rats.
Endocrinology 1988;122(3):985-90.
1988: Itoh H; Nakao K; Yamada T; Morii N; Shiono S; Sugawara A; Saito Y; Mukoyama M; Arai H; Imura H
Central interaction of the brain atrial natriuretic polypeptide (ANP) system and the brain renin-angiotensin system in ANP secretion from heart--evidence for possible brain-heart axis.
Canadian journal of physiology and pharmacology 1988;66(3):255-61.
1988: Mukoyama M; Nakao K; Yamada T; Itoh H; Sugawara A; Saito Y; Arai H; Hosoda K; Shirakami G; Morii N
A monoclonal antibody against N-terminus of alpha-atrial natriuretic polypeptide (alpha-ANP): a useful tool for preferential detection of naturally circulating ANP.
Biochemical and biophysical research communications 1988;151(3):1277-84.
1988: Yamada T; Nakao K; Itoh H; Morii N; Shiono S; Sakamoto M; Sugawara A; Saito Y; Mukoyama M; Arai H
Implication of leumorphin in inhibitory control of vasopressin secretion in conscious rats.
Hypertension 1988;11(2 Pt 2):I80-3.
1988: Itoh H; Nakao K; Yamada T; Morii N; Shiono S; Sugawara A; Saito Y; Mukoyama M; Arai H; Imura H
Brain renin-angiotensin. Central control of secretion of atrial natriuretic factor from the heart.
Hypertension 1988;11(2 Pt 2):I57-61.
1988: Itoh H; Nakao K; Mukoyama M; Sugawara A; Saito Y; Morii N; Yamada T; Shiono S; Arai H; Imura H
Secretion of N-terminal fragment of gamma-human atrial natriuretic polypeptide.
Hypertension 1988;11(2 Pt 2):I52-6.
1988: Sugawara A; Nakao K; Kono T; Morii N; Yamada T; Itoh H; Shiono S; Saito Y; Mukoyama M; Arai H
Atrial natriuretic factor in essential hypertension and adrenal disorders.
Hypertension 1988;11(2 Pt 2):I212-6.
1988: Sugawara A; Nakao K; Morii N; Yamada T; Itoh H; Shiono S; Saito Y; Mukoyama M; Arai H; Nishimura K
Augmented synthesis of beta-human atrial natriuretic polypeptide in human failing hearts.
Biochemical and biophysical research communications 1988;150(1):60-7.
1988: Yamada T; Nakao K; Itoh H; Shirakami G; Sugawara A; Saito Y; Mukoyama M; Arai H; Hosoda K; Morii N
Opioid modulation of vasopressin secretion in conscious rats.
Clinical and experimental hypertension. Part A, Theory and practice 1988;10 Suppl 1():361-7.
1988: Nakao K; Yamada T; Itoh H; Shirakami G; Saito Y; Sugawara A; Mukoyama M; Arai H; Hosoda K; Morii N
Possible antagonistic relationship between atrial natriuretic peptide (ANP)-brain natriuretic peptide (BNP) system and brain renin-angiotensin system in central control of body fluid and cardiovascular function.
Clinical and experimental hypertension. Part A, Theory and practice 1988;10(6):1289-91.
1987: Terada K; Nakao K; Okabe K; Kitamura K; Kuriyama H
Action of the 1,4-dihydropyridine derivative, KW-3049, on the smooth muscle membrane of the rabbit mesenteric artery.
British journal of pharmacology 1987;92(3):615-25.
1987: Itoh H; Nakao K; Morii N; Sugawara A; Yamada T; Shiono S; Saito Y; Mukoyama M; Arai H; Sakamoto M
Central actions of atrial natriuretic polypeptides in spontaneously hypertensive and normotensive rats.
Japanese circulation journal 1987;51(10):1208-15.
1987: Arai H; Nakao K; Saito Y; Morii N; Sugawara A; Yamada T; Itoh H; Shiono S; Mukoyama M; Ohkubo H
Simultaneous measurement of atrial natriuretic polypeptide (ANP) messenger RNA and ANP in rat heart--evidence for a preferentially increased synthesis and secretion of ANP in left atrium of spontaneously hypertensive rats (SHR).
Biochemical and biophysical research communications 1987;148(1):239-45.
1987: Saito Y; Nakao K; Arai H; Sugawara A; Morii N; Yamada T; Itoh H; Shiono S; Mukoyama M; Obata K
Atrial natriuretic polypeptide (ANP) in human ventricle. Increased gene expression of ANP in dilated cardiomyopathy.
Biochemical and biophysical research communications 1987;148(1):211-7.
1987: Nakao K; Sugawara A; Shiono S; Saito Y; Morii N; Yamada T; Itoh H; Mukoyama M; Arai H; Sakamoto M
Secretory form of atrial natriuretic polypeptide as cardiac hormone in humans and rats.
Canadian journal of physiology and pharmacology 1987;65(8):1756-61.
1987: Itoh H; Nakao K; Shiono S; Mukoyama M; Morii N; Sugawara A; Yamada T; Saito Y; Arai H; Kambayashi Y
Conversion of beta-human atrial natriuretic polypeptide into alpha-human atrial natriuretic polypeptide in human plasma in vitro.
Biochemical and biophysical research communications 1987;143(2):560-9.
1987: Sumimoto K; Domae M; Yamanaka K; Nakao K; Hashimoto T; Kitamura K; Kuriyama H
Actions of nicorandil on vascular smooth muscles.
Journal of cardiovascular pharmacology 1987;10 Suppl 8():S66-75.
1986: Itoh H; Nakao K; Yamada T; Morii N; Shiono S; Sakamoto M; Sugawara A; Saito Y; Katsuura G; Shiomi T
Centrally administered leumorphin possesses potent depressor activity in conscious rats.
NIDA research monograph 1986;75():512-5.
1986: Yamada T; Nakao K; Itoh H; Morii N; Shiono S; Sakamoto M; Sugawara A; Saito Y; Katsuura G; Eigyo M
Leumorphin is a potent inhibitor of vasopressin secretion.
NIDA research monograph 1986;75():335-8.
1980: Tanaka I; Nakai Y; Jingami H; Fukata J; Nakao K; Oki S; Nakanishi S; Numa S; Imura H
Existence of gamma-melanotropin (gamma-MSH)-like immunoreactivity in bovine and human pituitary glands.
Biochemical and biophysical research communications 1980;94(1):211-7.

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