FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Izumi Nakashima

Research Profile

Living Beings

Chemicals & Drugs

Physiology

Phenomena

Phosphorylation

Anatomy

Co-author Network

Publications

TOP 3
Kozue Takeda; Yoshiyuki Kawamoto; Yusuke Okuno; Masashi Kato; Masahide Takahashi; Haruhiko Suzuki; Kenichi Isobe; Izumi Nakashima
A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.
Izumi Nakashima
Evolution of humans outside the genome.
Izumi Nakashima; Kozue Takeda; Yoshiyuki Kawamoto; Yusuke Okuno; Masashi Kato; Haruhiko Suzuki
Redox control of catalytic activities of membrane-associated protein tyrosine kinases.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Izumi Nakashima (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2006: Kozue Takeda; Yoshiyuki Kawamoto; Yusuke Okuno; Masashi Kato; Masahide Takahashi; Haruhiko Suzuki; Kenichi Isobe; Izumi Nakashima
A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.
FEBS letters 2006;580(3):839-43.
2005: Izumi Nakashima
Evolution of humans outside the genome.
Nagoya journal of medical science 2005;67(3-4):59-64.
2005: Izumi Nakashima; Kozue Takeda; Yoshiyuki Kawamoto; Yusuke Okuno; Masashi Kato; Haruhiko Suzuki
Redox control of catalytic activities of membrane-associated protein tyrosine kinases.
Archives of biochemistry and biophysics 2005;434(1):3-10.
2005: Agustina Tri Endharti; Yan-Wen Zhou; Izumi Nakashima; Haruhiko Suzuki
Galectin-1 supports survival of naive T cells without promoting cell proliferation.
European journal of immunology 2005;35(1):86-97.
2004: Muhaimin Rifa'i; Yoshiyuki Kawamoto; Izumi Nakashima; Haruhiko Suzuki
Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis.
The Journal of experimental medicine 2004;200(9):1123-34.
2004: Hideo Tsuboi; Khaled Hossain; Anwarul A Akhand; Kozue Takeda; Jun Du; Muhaimin Rifa'i; Yan Dai; Akemi Hayakawa; Haruhiko Suzuki; Izumi Nakashima
Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism.
Journal of cellular biochemistry 2004;93(1):162-72.
2004: Hideo Hayashi; Michihiko Sone; Shosuke Ito; Kazumasa Wakamatsu; Masashi Kato; Izumi Nakashima; Tsutomu Nakashima
A novel RFP-RET transgenic mouse model with abundant eumelanin in the cochlea.
Hearing research 2004;195(1-2):35-40.
2004: Toshihiro Yokoyama; Jun Du; Yoshiyuki Kawamoto; Haruhiko Suzuki; Izumi Nakashima
Inhibition of Fas-mediated apoptotic cell death of murine T lymphocytes in a mouse model of immunosenescence in linkage to deterioration in cell membrane raft function.
Immunology 2004;112(1):64-71.
2004: Yoshiyuki Kawamoto; Kozue Takeda; Yusuke Okuno; Yoshinori Yamakawa; Yasutomo Ito; Ryo Taguchi; Masashi Kato; Haruhiko Suzuki; Masahide Takahashi; Izumi Nakashima
Identification of RET autophosphorylation sites by mass spectrometry.
The Journal of biological chemistry 2004;279(14):14213-24.
2004: Yoshikazu Takagi; Jun Du; Xiu-Yang Ma; Izumi Nakashima; Fumihiko Nagase
Phorbol 12-myristate 13-acetate protects Jurkat cells from methylglyoxal-induced apoptosis by preventing c-Jun N-terminal kinase-mediated leakage of cytochrome c in an extracellular signal-regulated kinase-dependent manner.
Molecular pharmacology 2004;65(3):778-87.
2004: Masashi Kato; Kozue Takeda; Yoshiyuki Kawamoto; Toyonori Tsuzuki; Khaled Hossain; Akiko Tamakoshi; Takahiro Kunisada; Yasuhiro Kambayashi; Keiki Ogino; Haruhiko Suzuki; Masahide Takahashi; Izumi Nakashima
c-Kit-targeting immunotherapy for hereditary melanoma in a mouse model.
Cancer research 2004;64(3):801-6.
2003: Tomohiro Kajiguchi; Kazuhito Yamamoto; Khaled Hossain; Anwarul A Akhand; Izumi Nakashima; Tomoki Naoe; Hidehiko Saito; Nobuhiko Emi
Sustained activation of c-jun-terminal kinase (JNK) is closely related to arsenic trioxide-induced apoptosis in an acute myeloid leukemia (M2)-derived cell line, NKM-1.
Leukemia 2003;17(11):2189-95.
2003: Akeyo Horie; Yoshiyuki Hiki; Hiroko Odani; Yoshinari Yasuda; Mami Takahashi; Masashi Kato; Hitoo Iwase; Yutaka Kobayashi; Izumi Nakashima; Kenji Maeda
IgA1 molecules produced by tonsillar lymphocytes are under-O-glycosylated in IgA nephropathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2003;42(3):486-96.
2003: Izumi Nakashima; Wei Liu; Anwarul A Akhand; Kozue Takeda; Yoshiyuki Kawamoto; Masashi Kato; Haruhiko Suzuki
4-hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions.
Molecular aspects of medicine 2003;24(4-5):231-8.
2003: Yan-Wen Zhou; Sayoko Aritake; Agustina Tri Endharti; Jianghong Wu; Akemi Hayakawa; Izumi Nakashima; Haruhiko Suzuki
Murine lymph node-derived stromal cells effectively support survival but induce no activation/proliferation of peripheral resting T cells in vitro.
Immunology 2003;109(4):496-503.
2003: Haruhiko Suzuki; Jianghong Wu; Khaled Hossain; Tatsuya Ohhata; Jun Du; Anwarul A Akhand; Akemi Hayakawa; Hiroshi Kimura; Masatoshi Hagiwara; Izumi Nakashima
Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1538-40.
2003: Jun Du; Shaohui Cai; Haruhiko Suzuki; Anwarul A Akhand; Xiuyang Ma; Yoshikazu Takagi; Toshio Miyata; Izumi Nakashima; Fumihiko Nagase
Involvement of MEKK1/ERK/P21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal.
Journal of cellular biochemistry 2003;88(6):1235-46.
2003: Khaled Hossain; Anwarul A Akhand; Yoshiyuki Kawamoto; Jun Du; Kozue Takeda; Jianghong Wu; Motoi Yoshihara; Hideo Tsuboi; Masashi Kato; Haruhiko Suzuki; Izumi Nakashima
Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation.
Free radical biology & medicine 2003;34(5):598-606.
2002: Izumi Nakashima; Masashi Kato; Anwarul A Akhand; Haruhiko Suzuki; Kozue Takeda; Khaled Hossain; Yoshiyuki Kawamoto
Redox-linked signal transduction pathways for protein tyrosine kinase activation.
Antioxidants & redox signaling 2002;4(3):517-31.
2002: Anwarul A Akhand; Jun Du; Wei Liu; Khaled Hossain; Toshio Miyata; Fumihiko Nagase; Masashi Kato; Haruhiko Suzuki; Izumi Nakashima
Redox-linked cell surface-oriented signaling for T-cell death.
Antioxidants & redox signaling 2002;4(3):445-54.
2002: Xiuyang Ma; Jun Du; Izumi Nakashima; Fumihiko Nagase
Menadione biphasically controls JNK-linked cell death in leukemia Jurkat T cells.
Antioxidants & redox signaling 2002;4(3):371-8.
2002: Jianghong Wu; Haruhiko Suzuki; Anwarul A Akhand; Yan-Wen Zhou; Khaled Hossain; Izumi Nakashima
Modes of activation of mitogen-activated protein kinases and their roles in cepharanthine-induced apoptosis in human leukemia cells.
Cellular signalling 2002;14(6):509-15.
2002: Masashi Kato; Kozue Takeda; Yoshiyuki Kawamoto; Toshihide Iwashita; Anwarul A Akhand; Takeshi Senga; Masahiko Yamamoto; Gen Sobue; Michinari Hamaguchi; Masahide Takahashi; Izumi Nakashima
Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine.
Cancer research 2002;62(8):2414-22.
2002: Anwarul A Akhand; Takanari Ikeyama; Satoru Akazawa; Masashi Kato; Khaled Hossain; Kozue Takeda; Haruhiko Suzuki; Masahide Takahashi; Izumi Nakashima
Evidence of both extra- and intracellular cysteine targets of protein modification for activation of RET kinase.
Biochemical and biophysical research communications 2002;292(4):826-31.
2002: Akemi Hayakawa; Jianghong Wu; Y Kawamoto; Yan-Wen Zhou; S Tanuma; Izumi Nakashima; Haruhiko Suzuki
Activation of caspase-8 is critical for sensitivity to cytotoxic anti-Fas antibody-induced apoptosis in human ovarian cancer cells.
Apoptosis : an international journal on programmed cell death 2002;7(2):107-13.
2002: Keitarou Kamei; Yuji Nimura; Masato Nagino; Keiya Aono; Izumi Nakashima
Surgical stress reduces mortality from endotoxin shock.
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie 2002;386(7):512-7.
2001: Anwarul A Akhand; Khaled Hossain; Masashi Kato; Toshio Miyata; Jun Du; Haruhiko Suzuki; Kei Kurokawa; Izumi Nakashima
Glyoxal and methylglyoxal induce lyoxal and methyglyoxal induce aggregation and inactivation of ERK in human endothelial cells.
Free radical biology & medicine 2001;31(10):1228-35.
2001: Masashi Kato; Kozue Takeda; Yoshiyuki Kawamoto; Toyonori Tsuzuki; Y Dai; S Nakayama; K Toriyama; Y Tamada; Masahide Takahashi; Izumi Nakashima
RET tyrosine kinase enhances hair growth in association with promotion of melanogenesis.
Oncogene 2001;20(51):7536-41.
2001: Y Dai; Masashi Kato; Kozue Takeda; Yoshiyuki Kawamoto; Anwarul A Akhand; Khaled Hossain; Haruhiko Suzuki; Izumi Nakashima
T-cell-immunity-based inhibitory effects of orally administered herbal medicine juzen-taiho-to on the growth of primarily developed melanocytic tumors in RET-transgenic mice.
The Journal of investigative dermatology 2001;117(3):694-701.
2001: Jun Du; Haruhiko Suzuki; Fumihiko Nagase; Anwarul A Akhand; X Y Ma; T Yokoyama; Toshio Miyata; Izumi Nakashima
Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process.
Free radical biology & medicine 2001;31(4):469-78.
2001: Anwarul A Akhand; Khaled Hossain; H Mitsui; Masashi Kato; Toshio Miyata; R Inagi; Jun Du; Kozue Takeda; Yoshiyuki Kawamoto; Haruhiko Suzuki; Kei Kurokawa; Izumi Nakashima
Glyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in human endothelial cells.
Free radical biology & medicine 2001;31(1):20-30.
2001: Kozue Takeda; Masashi Kato; J Wu; Toshihide Iwashita; Haruhiko Suzuki; Masahide Takahashi; Izumi Nakashima
Osmotic stress-mediated activation of RET kinases involves intracellular disulfide-bonded dimer formation.
Antioxidants & redox signaling 2001;3(3):473-82.
2001: Jianghong Wu; Haruhiko Suzuki; Yan-Wen Zhou; W Liu; Motoi Yoshihara; Masashi Kato; Anwarul A Akhand; Akemi Hayakawa; K Takeuchi; Khaled Hossain; M Kurosawa; Izumi Nakashima
Cepharanthine activates caspases and induces apoptosis in Jurkat and K562 human leukemia cell lines.
Journal of cellular biochemistry 2001;82(2):200-14.
2001: K Takeuchi; Masashi Kato; Haruhiko Suzuki; Anwarul A Akhand; Jianghong Wu; Khaled Hossain; Toshio Miyata; Y Matsumoto; Yuji Nimura; Izumi Nakashima
Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death.
Journal of cellular biochemistry 2001;81(4):679-88.
2000: M Kato; W Liu; Anwarul A Akhand; Khaled Hossain; K Takeda; M Takahashi; Izumi Nakashima
Ultraviolet radiation induces both full activation of ret kinase and malignant melanocytic tumor promotion in RFP-RET-transgenic mice.
The Journal of investigative dermatology 2000;115(6):1157-8.
2000: Khaled Hossain; Anwarul A Akhand; Masashi Kato; Jun Du; Kozue Takeda; Jianghong Wu; K Takeuchi; W Liu; Haruhiko Suzuki; Izumi Nakashima
Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4290-7.
2000: Jun Du; Haruhiko Suzuki; Fumihiko Nagase; Anwarul A Akhand; T Yokoyama; Izumi Nakashima
Mercuric chloride stimulates distinct signal transduction pathway for DNA synthesis in a T-cell line, CTLL-2.
Journal of cellular biochemistry 2000;78(3):500-8.
2000: Jun Du; Haruhiko Suzuki; Fumihiko Nagase; Anwarul A Akhand; T Yokoyama; Toshio Miyata; Kei Kurokawa; Izumi Nakashima
Methylglyoxal induces apoptosis in Jurkat leukemia T cells by activating c-Jun N-terminal kinase.
Journal of cellular biochemistry 2000;77(2):333-44.
2000: Akemi Hayakawa; T Kojima; Itsuo Yokoyama; Haruhiko Suzuki; H Tajiri; Izumi Nakashima
A short peptide derived from the antisense homology box of Fas ligand induces apoptosis in anti-Fas antibody-insensitive human ovarian cancer cells.
Apoptosis : an international journal on programmed cell death 2000;5(1):37-41.
2000: W Liu; M Kato; Anwarul A Akhand; Akemi Hayakawa; Haruhiko Suzuki; T Miyata; Kei Kurokawa; Y Hotta; N Ishikawa; Izumi Nakashima
4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death.
Journal of cell science 2000;113 ( Pt 4)():635-41.
2000: Takeshi Senga; Kou Miyazaki; Kazuya Machida; H Iwata; Satoru Matsuda; Izumi Nakashima; Michinari Hamaguchi
Clustered cysteine residues in the kinase domain of v-Src: critical role for protein stability, cell transformation and sensitivity to herbimycin A.
Oncogene 2000;19(2):273-9.
2000: Masashi Kato; Toshihide Iwashita; Anwarul A Akhand; Wei Liu; Kozue Takeda; K Takeuchi; Motoi Yoshihara; Khaled Hossain; J Wu; Jun Du; C Oh; Yoshiyuki Kawamoto; Haruhiko Suzuki; Masahide Takahashi; Izumi Nakashima
Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation.
Antioxidants & redox signaling 2000;2(4):841-9.
2000: Masashi Kato; Toshihide Iwashita; Kozue Takeda; Anwarul A Akhand; Wei Liu; Motoi Yoshihara; Naoya Asai; Haruhiko Suzuki; Masahide Takahashi; Izumi Nakashima
Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosine kinases.
Molecular biology of the cell 2000;11(1):93-101.
1999: Haruhiko Suzuki; Yan-Wen Zhou; Masashi Kato; T W Mak; Izumi Nakashima
Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo.
The Journal of experimental medicine 1999;190(11):1561-72.
1999: Izumi Nakashima
[Signal transduction pathways for activation of Src family protein tyrosine kinases in stress responses].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(15 Suppl):2420-6.
1999: Anwarul A Akhand; M Pu; Takeshi Senga; Masashi Kato; Haruhiko Suzuki; T Miyata; Michinari Hamaguchi; Izumi Nakashima
Nitric oxide controls src kinase activity through a sulfhydryl group modification-mediated Tyr-527-independent and Tyr-416-linked mechanism.
The Journal of biological chemistry 1999;274(36):25821-6.
1999: W Liu; Anwarul A Akhand; M Kato; I Yokoyama; T Miyata; Kei Kurokawa; K Uchida; Izumi Nakashima
4-hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition.
Journal of cell science 1999;112 ( Pt 14)():2409-17.
1999: Masashi Kato; Wei Liu; Anwarul A Akhand; Y Dai; Masayoshi Ohbayashi; T Tuzuki; Haruhiko Suzuki; K Isobe; Masahide Takahashi; Izumi Nakashima
Linkage between melanocytic tumor development and early burst of Ret protein expression for tolerance induction in metallothionein-I/ret transgenic mouse lines.
Oncogene 1999;18(3):837-42.
1999: M Asai; Masashi Kato; Naoya Asai; Toshihide Iwashita; Hideki Murakami; Kumi Kawai; Izumi Nakashima; Masahide Takahashi
Differential regulation of MMP-9 and TIMP-2 expression in malignant melanoma developed in metallothionein/RET transgenic mice.
Japanese journal of cancer research : Gann 1999;90(1):86-92.
1999: Anwarul A Akhand; Masashi Kato; Haruhiko Suzuki; W Liu; Jun Du; Michinari Hamaguchi; Toshio Miyata; Kei Kurokawa; Izumi Nakashima
Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-Src.
Journal of cellular biochemistry 1999;72(1):1-7.
1999: A Parashar; Anwarul A Akhand; R Rawar; T Furuno; M Nakanishi; Masashi Kato; Haruhiko Suzuki; Izumi Nakashima
Mercuric chloride induces increases in both cytoplasmic and nuclear free calcium ions through a protein phosphorylation-linked mechanism.
Free radical biology & medicine 1999;26(1-2):227-31.
1998: Anwarul A Akhand; Masashi Kato; Haruhiko Suzuki; Toshio Miyata; Izumi Nakashima
Level of HgCl2-mediated phosphorylation of intracellular proteins determines death of thymic T-lymphocytes with or without DNA fragmentation.
Journal of cellular biochemistry 1998;71(2):243-53.
1998: Masashi Kato; Masahide Takahashi; Anwarul A Akhand; Wei Liu; Y Dai; S Shimizu; Takashi Iwamoto; Haruhiko Suzuki; Izumi Nakashima
Transgenic mouse model for skin malignant melanoma.
Oncogene 1998;17(14):1885-8.
1998: Masashi Kato; W Liu; H Yi; N Asai; A Hayakawa; K Kozaki; M Takahashi; Izumi Nakashima
The herbal medicine Sho-saiko-to inhibits growth and metastasis of malignant melanoma primarily developed in ret-transgenic mice.
The Journal of investigative dermatology 1998;111(4):640-4.
1998: W Liu; M Kato; Anwarul A Akhand; Akemi Hayakawa; M Takemura; S Yoshida; H Suzuki; Izumi Nakashima
The herbal medicine sho-saiko-to inhibits the growth of malignant melanoma cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulation of cyclin dependent kinases.
International journal of oncology 1998;12(6):1321-6.
1998: A Takeuchi; Ken-Ichi Isobe; O Miyaishi; M Sawada; ZH Fan; Izumi Nakashima; K Kiuchi
Microglial NO induces delayed neuronal death following acute injury in the striatum.
The European journal of neuroscience 1998;10(5):1613-20.
1998: G Wang; M Nonaka; C He; Noriko Okada; Izumi Nakashima; Hidechika Okada
Functional differences among multiple isoforms of guinea pig decay-accelerating factor.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(6):3014-22.
1998: Fumihiko Nagase; T Abo; K Hiramatsu; S Suzuki; Jun Du; Izumi Nakashima
Induction of apoptosis and tyrosine phosphorylation of cellular proteins in T cells and non-T cells by stimulation with concanavalin A.
Microbiology and immunology 1998;42(8):567-74.
1997: E Yamada; N Ishiguro; O Miyaishi; A Takeuchi; Izumi Nakashima; H Iwata; K Isobe
Differential display analysis of murine collagen-induced arthritis: cloning of the cDNA-encoding murine ATPase inhibitor.
Immunology 1997;92(4):571-6.
1997: H Sano; M Hirai; Hidehiko Saito; Izumi Nakashima; K I Isobe
A nitric oxide-releasing reagent, S-nitroso-N-acetylpenicillamine, enhances the expression of superoxide dismutases mRNA in the murine macrophage cell line RAW264-7.
Immunology 1997;92(1):118-22.
1997: Haruhiko Suzuki; A Hayakawa; D Bouchard; Izumi Nakashima; T W Mak
Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor beta chain-deficient mice.
International immunology 1997;9(9):1367-74.
1997: K Ohkusu; Jun Du; Ken-Ichi Isobe; H Yi; Anwarul A Akhand; Masashi Kato; Haruhiko Suzuki; H Hidaka; Izumi Nakashima
Protein kinase C alpha-mediated chronic signal transduction for immunosenescence.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2082-4.
1997: Keiya Aono; Ken-Ichi Isobe; K Kiuchi; ZH Fan; M Ito; A Takeuchi; M Miyachi; Izumi Nakashima; Yuji Nimura
In vitro and in vivo expression of inducible nitric oxide synthase during experimental endotoxemia: involvement of other cytokines.
Journal of cellular biochemistry 1997;65(3):349-58.
1997: Anwarul A Akhand; M Pu; Jun Du; Masashi Kato; Haruhiko Suzuki; Michinari Hamaguchi; Izumi Nakashima
Magnitude of protein tyrosine phosphorylation-linked signals determines growth versus death of thymic T lymphocytes.
European journal of immunology 1997;27(5):1254-9.
1997: Y Nozaki; Yoshinori Hasegawa; A Takeuchi; ZH Fan; Ken-Ichi Isobe; Izumi Nakashima; Kaoru Shimokata
Nitric oxide as an inflammatory mediator of radiation pneumonitis in rats.
The American journal of physiology 1997;272(4 Pt 1):L651-8.