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Shigeru Nakashima

Research Profile

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Motoshi Sawada; Tohru Kiyono; Shigeru Nakashima; Jun Shinoda; Takashi Naganawa; Shigeru Hara; Toru Iwama; Noboru Sakai
Molecular mechanisms of TNF-alpha-induced ceramide formation in human glioma cells: P53-mediated oxidant stress-dependent and -independent pathways.
Shigeru Hara; Shigeru Nakashima; Tohru Kiyono; Motoshi Sawada; Shinichi Yoshimura; Toru Iwama; Yoshiko Banno; Jun Shinoda; Noboru Sakai
p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis.
Shigeru Hara; Shigeru Nakashima; Tohru Kiyono; Motoshi Sawada; Shinichi Yoshimura; Toru Iwama; Noboru Sakai
Ceramide triggers caspase activation during gamma-radiation-induced apoptosis of human glioma cells lacking functional p53.

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2004: Motoshi Sawada; Tohru Kiyono; Shigeru Nakashima; Jun Shinoda; Takashi Naganawa; Shigeru Hara; Toru Iwama; Noboru Sakai
Molecular mechanisms of TNF-alpha-induced ceramide formation in human glioma cells: P53-mediated oxidant stress-dependent and -independent pathways.
Cell death and differentiation 2004;11(9):997-1008.
2004: Shigeru Hara; Shigeru Nakashima; Tohru Kiyono; Motoshi Sawada; Shinichi Yoshimura; Toru Iwama; Yoshiko Banno; Jun Shinoda; Noboru Sakai
p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis.
Cell death and differentiation 2004;11(8):853-61.
2004: Shigeru Hara; Shigeru Nakashima; Tohru Kiyono; Motoshi Sawada; Shinichi Yoshimura; Toru Iwama; Noboru Sakai
Ceramide triggers caspase activation during gamma-radiation-induced apoptosis of human glioma cells lacking functional p53.
Oncology reports 2004;12(1):119-23.
2004: You Tsuchiya; Shigeru Nakashima; Yoshiko Banno; Yuichi Suzuki; Hironobu Morita
Effect of high-NaCl or high-KCl diet on hepatic Na+- and K+-receptor sensitivity and NKCC1 expression in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;286(3):R591-6.
2004: Kenta Aoki; Tetsuya Ogawa; Yatsuji Ito; Shigeru Nakashima
Cisplatin activates survival signals in UM-SCC-23 squamous cell carcinoma and these signal pathways are amplified in cisplatin-resistant squamous cell carcinoma.
Oncology reports 2004;11(2):375-9.
2003: Yosuke Osawa; Masahito Nagaki; Yoshiko Banno; David A Brenner; Yoshinori Nozawa; Hisataka Moriwaki; Shigeru Nakashima
Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4053-60.
2003: Jun Yamada; Shinichi Yoshimura; Haruki Yamakawa; Motoshi Sawada; Masanori Nakagawa; Shigeru Hara; Yasuhiko Kaku; Toru Iwama; Takashi Naganawa; Yoshiko Banno; Shigeru Nakashima; Noboru Sakai
Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation.
Neuroscience research 2003;45(1):1-8.
2002: Shigeru Nakashima
Protein kinase C alpha (PKC alpha): regulation and biological function.
Journal of biochemistry 2002;132(5):669-75.
2002: Yosuke Osawa; Masahito Nagaki; Yoshiko Banno; David A Brenner; Takahiko Asano; Yoshinori Nozawa; Hisataka Moriwaki; Shigeru Nakashima
Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes.
Infection and immunity 2002;70(11):6294-301.
2002: Masanori Nakagawa; Shigeru Nakashima; Yoshiko Banno; Jun Yamada; Motoshi Sawada; Shin ichi Yoshimura; Yasuhiko Kaku; Toru Iwama; Jun Shinoda; Noboru Sakai
Increased expression and secretion of r-Gsp protein, rat counterpart of complement C1s precursor, during cyclic AMP-induced differentiation in rat C6 glioma cells.
Brain research. Molecular brain research 2002;106(1-2):12-21.
2002: Naoki Okumura; Shigetoyo Saji; Hidetaka Eguchi; Shin-ichi Hayashi; Shigetoyo Saji; Shigeru Nakashima
Estradiol stabilizes p53 protein in breast cancer cell line, MCF-7.
Japanese journal of cancer research : Gann 2002;93(8):867-73.
2002: Naoki Okumura; Shigehira Saji; Hidetaka Eguchi; Shigeru Nakashima; Shigetoyo Saji; Shin-Ichi Hayashi
Distinct promoter usage of mdm2 gene in human breast cancer.
Oncology reports 2002;9(3):557-63.
2002: Motoshi Sawada; Shigeru Nakashima; Tohru Kiyono; Jun Yamada; Shigeru Hara; Masanori Nakagawa; Jun Shinoda; Noboru Sakai
Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells.
Experimental cell research 2002;273(2):157-68.
2001: Yosuke Osawa; Yoshiko Banno; Masahito Nagaki; Yoshinori Nozawa; Hisataka Moriwaki; Shigeru Nakashima
Caspase activation during hepatocyte apoptosis induced by tumor necrosis factor-alpha in galactosamine-sensitized mice.
Liver 2001;21(5):309-19.
2001: Yoshiko Banno; Yoh Takuwa; Yukihiro Akao; H Okamoto; Yosuke Osawa; Takashi Naganawa; Shigeru Nakashima; P G Suh; Yoshinori Nozawa
Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3.
The Journal of biological chemistry 2001;276(38):35622-8.
2001: Yosuke Osawa; Masahito Nagaki; Yoshiko Banno; Yoshinori Nozawa; Hisataka Moriwaki; Shigeru Nakashima
Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor.
Biochemical and biophysical research communications 2001;286(4):673-7.
2001: Yoshiko Banno; Shulin Wang; Y Ito; T Izumi; Shigeru Nakashima; T Shimizu; Yoshinori Nozawa
Involvement of ERK and p38 MAP kinase in oxidative stress-induced phospholipase D activation in PC12 cells.
Neuroreport 2001;12(10):2271-5.
2001: Haruki Yamakawa; Yoshiko Banno; Shigeru Nakashima; Shinichi Yoshimura; Motoshi Sawada; Y Nishimura; Yoshinori Nozawa; Noboru Sakai
Crucial role of calpain in hypoxic PC12 cell death: calpain, but not caspases, mediates degradation of cytoskeletal proteins and protein kinase C-alpha and -delta.
Neurological research 2001;23(5):522-30.
2001: Yosuke Osawa; Yoshiko Banno; Masahito Nagaki; David A Brenner; Takafumi Naiki; Yoshinori Nozawa; Shigeru Nakashima; Hisataka Moriwaki
TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):173-80.
2001: Yosuke Osawa; Masahito Nagaki; Yoshiko Banno; Y Yamada; Motoaki Imose; Yoshinori Nozawa; Hisataka Moriwaki; Shigeru Nakashima
Possible involvement of reactive oxygen species in D-galactosamine-induced sensitization against tumor necrosis factor-alpha-induced hepatocyte apoptosis.
Journal of cellular physiology 2001;187(3):374-85.
2001: Motoshi Sawada; Shigeru Nakashima; Tohru Kiyono; Masanori Nakagawa; Jun Yamada; Haruki Yamakawa; Yoshiko Banno; Jun Shinoda; Y Nishimura; Yoshinori Nozawa; Noboru Sakai
p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells.
Oncogene 2001;20(11):1368-78.
2001: Shulin Wang; Yoshiko Banno; Shigeru Nakashima; Yoshinori Nozawa
Enzymatic characterization of phospholipase D of protozoan Tetrahymena cells.
The Journal of eukaryotic microbiology 2001;48(2):194-201.
2001: S Noda; Shinichi Yoshimura; Motoshi Sawada; Takashi Naganawa; Toru Iwama; Shigeru Nakashima; Noboru Sakai
Role of ceramide during cisplatin-induced apoptosis in C6 glioma cells.
Journal of neuro-oncology 2001;52(1):11-21.
2000: Masahito Nagaki; Takafumi Naiki; David A Brenner; Yosuke Osawa; Motoaki Imose; Hideki Hayashi; Yoshiko Banno; Shigeru Nakashima; Hisataka Moriwaki
Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB.
Hepatology (Baltimore, Md.) 2000;32(6):1272-9.
2000: H Yamakawa; Yoshiko Banno; Shigeru Nakashima; M Sawada; J Yamada; Shinichi Yoshimura; Y Nishimura; Yoshinori Nozawa; Noboru Sakai
Increased phospholipase D2 activity during hypoxia-induced death of PC12 cells: its possible anti-apoptotic role.
Neuroreport 2000;11(16):3647-50.
2000: Haruki Yamakawa; Y Ito; Takashi Naganawa; Yoshiko Banno; Shigeru Nakashima; Shinichi Yoshimura; Motoshi Sawada; Y Nishimura; Yoshinori Nozawa; Noboru Sakai
Activation of caspase-9 and -3 during H2O2-induced apoptosis of PC12 cells independent of ceramide formation.
Neurological research 2000;22(6):556-64.
2000: Motoshi Sawada; Shigeru Nakashima; Yoshiko Banno; Haruki Yamakawa; K Hayashi; K Takenaka; Y Nishimura; Noboru Sakai; Yoshinori Nozawa
Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells.
Cell death and differentiation 2000;7(9):761-72.
2000: Motoshi Sawada; Shigeru Nakashima; Yoshiko Banno; Haruki Yamakawa; K Takenaka; Jun Shinoda; Y Nishimura; Noboru Sakai; Yoshinori Nozawa
Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells.
Oncogene 2000;19(31):3508-20.
2000: A Watanabe; Shigeru Nakashima; T Adachi; Shigetoyo Saji; Yoshinori Nozawa
Changes in the expression of lipid-mediated signal-transducing enzymes in the rat liver after partial hepatectomy.
Surgery today 2000;30(7):622-30.
1999: Zhiming Tan; Shuji Dohi; Kenji Ohguchi; Shigeru Nakashima; Yoshiko Banno; Y Ono; Yoshinori Nozawa
Effects of local anesthetics on phospholipase D activity in differentiated human promyelocytic leukemic HL60 cells.
Biochemical pharmacology 1999;58(12):1881-9.
1999: Masahito Nagaki; A Sugiyama; Yosuke Osawa; Takafumi Naiki; Shigeru Nakashima; Yoshinori Nozawa; Hisataka Moriwaki
Lethal hepatic apoptosis mediated by tumor necrosis factor receptor, unlike Fas-mediated apoptosis, requires hepatocyte sensitization in mice.
Journal of hepatology 1999;31(6):997-1005.
1999: Shulin Wang; Shigeru Nakashima; Osamu Numata; Kenta Fujiu; Yoshinori Nozawa
Molecular cloning and cell-cycle-dependent expression of the acetyl-CoA synthetase gene in Tetrahymena cells.
The Biochemical journal 1999;343 Pt 2():479-85.
1999: Zhiming Tan; Shuji Dohi; Kenji Ohguchi; Shigeru Nakashima; Yoshinori Nozawa
Local anesthetics inhibit muscarinic receptor-mediated activation of extracellular signal-regulated kinases in rat pheochromocytoma PC12 cells.
Anesthesiology 1999;91(4):1014-24.
1999: Yoshiko Banno; H Fujita; Y Ono; Shigeru Nakashima; Y Ito; N Kuzumaki; Yoshinori Nozawa
Differential phospholipase D activation by bradykinin and sphingosine 1-phosphate in NIH 3T3 fibroblasts overexpressing gelsolin.
The Journal of biological chemistry 1999;274(39):27385-91.
1999: Shigeru Nakashima
[Inositol].
Nihon rinsho. Japanese journal of clinical medicine 1999;57 Suppl():176-8.
1999: Shinichi Yoshimura; Yoshiko Banno; Shigeru Nakashima; K Hayashi; Haruki Yamakawa; Motoshi Sawada; Noboru Sakai; Yoshinori Nozawa
Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death.
Journal of neurochemistry 1999;73(2):675-83.
1999: Kenji Ohguchi; Shigeru Nakashima; Yoshinori Nozawa
Phospholipase D development during differentiation of human promyelocytic leukemic HL60 cells.
Biochimica et biophysica acta 1999;1439(2):215-27.
1999: Y Zhao; Shigeru Nakashima; Yoshinori Nozawa
Molecular cloning of a cDNA encoding 14-3-3 protein from the protozoan Tetrahymena pyriformis and its mRNA expression during synchronous division.
Gene 1999;234(2):209-15.
1999: KV Takenaka; H Sakai; Haruki Yamakawa; T Itoh; S Murase; H Yamakawa; A Okumura; Y Nishimura; T Andoh; Shigeru Nakashima; Yoshinori Nozawa; Noboru Sakai
Analysis of phospholipase C gene in patients with subarachnoid hemorrhage due to ruptured intracranial saccular aneurysm.
Neurological research 1999;21(4):368-72.
1999: Shigeru Nakashima; Yoshinori Nozawa
[Roles of phospholipase D in signal transduction].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(8 Suppl):998-1006.
1999: K Hayakawa; Shigeru Nakashima; Y Ito; K Mizuta; H Miyata; Yoshinori Nozawa
Increased expression of phospholipase D1 mRNA during cAMP- or NGF-induced differentiation in PC12 cells.
Neuroscience letters 1999;265(2):127-30.
1999: Shigeru Nakashima; Shulin Wang; N Hisamoto; H Sakai; M Andoh; K Matsumoto; Yoshinori Nozawa
Molecular cloning and expression of a stress-responsive mitogen-activated protein kinase-related kinase from Tetrahymena cells.
The Journal of biological chemistry 1999;274(15):9976-83.
1999: Shigeru Nakashima; Yoshinori Nozawa
Possible role of phospholipase D in cellular differentiation and apoptosis.
Chemistry and physics of lipids 1999;98(1-2):153-64.
1999: Y Sugiyama; Shigeru Nakashima; F Mirbod; H Kanoh; Y Kitajima; Mahmoud A Ghannoum; Yoshinori Nozawa
Molecular cloning of a second phospholipase B gene, caPLB2 from Candida albicans.
Medical mycology : official publication of the International Society for Human and Animal Mycology 1999;37(1):61-7.
1999: Shigetoyo Saji; Shigeru Nakashima; S Hayashi; M Toi; S Saji; Y Nozawa
Overexpression of MDM2 in MCF-7 promotes both growth advantage and p53 accumulation in response to estradiol.
Japanese journal of cancer research : Gann 1999;90(2):210-8.
1999: Shigeru Nakashima; Yoshinori Nozawa
Stress-responsive gene expression in Tetrahymena.
Acta biologica Hungarica 1999;50(4):413-24.
1998: T Kasai; Kenji Ohguchi; Shigeru Nakashima; Y Ito; Takashi Naganawa; Naomi Kondo; Yoshinori Nozawa
Increased activity of oleate-dependent type phospholipase D during actinomycin D-induced apoptosis in Jurkat T cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6469-74.
1998: Y Ito; Shigeru Nakashima; Yoshinori Nozawa
Possible involvement of mitogen-activated protein kinase in phospholipase D activation induced by H2O2, but not by carbachol, in rat pheochromocytoma PC12 cells.
Journal of neurochemistry 1998;71(6):2278-85.
1998: Steven D Leidich; Ashraf S Ibrahim; Y Fu; A Koul; CJ Jessup; J Vitullo; William A Fonzi; F Mirbod; Shigeru Nakashima; Yoshinori Nozawa; Mahmoud A Ghannoum
Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans.
The Journal of biological chemistry 1998;273(40):26078-86.
1998: T Mizutani; Shigeru Nakashima; Yoshinori Nozawa
Changes in the expression of protein kinase C (PKC), phospholipases C (PLC) and D (PLD) isoforms in spleen, brain and kidney of the aged rat: RT-PCR and Western blot analysis.
Mechanisms of ageing and development 1998;105(1-2):151-72.
1998: Shulin Wang; Shigeru Nakashima; H Sakai; Osamu Numata; Kenta Fujiu; Yoshinori Nozawa
Molecular cloning and cell-cycle-dependent expression of a novel NIMA (never-in-mitosis in Aspergillus nidulans)-related protein kinase (TpNrk) in Tetrahymena cells.
The Biochemical journal 1998;334 ( Pt 1)():197-203.
1998: H Kanoh; Shigeru Nakashima; Y Zhao; Y Sugiyama; Yasuo Kitajima; Yoshinori Nozawa
Molecular cloning of a gene encoding phospholipase D from the pathogenic and dimorphic fungus, Candida albicans.
Biochimica et biophysica acta 1998;1398(3):359-64.
1998: Shinichi Yoshimura; Yoshiko Banno; Shigeru Nakashima; K Takenaka; H Sakai; Y Nishimura; Noboru Sakai; S Shimizu; Y Eguchi; Y Tsujimoto; Yoshinori Nozawa
Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation.
The Journal of biological chemistry 1998;273(12):6921-7.
1998: H Sakai; Shigeru Nakashima; Shin ichi Yoshimura; Y Nishimura; Noboru Sakai; Yoshinori Nozawa
Molecular cloning of a cDNA encoding a serine protease homologous to complement C1s precursor from rat C6 glial cells and its expression during glial differentiation.
Gene 1998;209(1-2):87-94.
1998: Shigeru Nakashima; Kenji Ohguchi; M A Frohman; Yoshinori Nozawa
Increased mRNA expression of phospholipase D (PLD) isozymes during granulocytic differentiation of HL60 cells.
Biochimica et biophysica acta 1998;1389(3):173-7.
1998: H Kanoh; Shigeru Nakashima; Yasuo Kitajima; Yoshinori Nozawa
[Molecular cloning of Candida albicans phospholipase D].
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 1998;39(2):79-83.
1997: B Liu; Shigeru Nakashima; T Adachi; Y Ito; T Takano; T Shimizu; Yoshinori Nozawa
Prolonged activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating-factor receptor lacking cytoplasmic C-terminal tail.
The Biochemical journal 1997;327 ( Pt 1)():239-44.
1997: Y Zhao; Shigeru Nakashima; M Andoh; Yoshinori Nozawa
Cloning and sequencing of a cDNA encoding glyceraldehyde-3-phosphate dehydrogenase from Tetrahymena thermophila: growth-associated changes in its mRNA expression.
The Journal of eukaryotic microbiology 1997;44(5):435-7.
1997: T Adachi; Shigeru Nakashima; Shigetoyo Saji; Toshikazu Nakamura; Yoshinori Nozawa
Possible involvement of pertussis toxin-sensitive G protein in hepatocyte growth factor-induced signal transduction in cultured rat hepatocytes: pertussis toxin treatment inhibits activation of phospholipid signaling, calcium oscillation, and mitogen-activated protein kinase.
Hepatology (Baltimore, Md.) 1997;26(2):295-300.
1997: Y Ito; Shigeru Nakashima; Yoshinori Nozawa
Hydrogen peroxide-induced phospholipase D activation in rat pheochromocytoma PC12 cells: possible involvement of Ca2+-dependent protein tyrosine kinase.
Journal of neurochemistry 1997;69(2):729-36.
1997: Shinichi Yoshimura; H Sakai; Kenji Ohguchi; Shigeru Nakashima; Yoshiko Banno; Y Nishimura; Noboru Sakai; Yoshinori Nozawa
Changes in the activity and mRNA levels of phospholipase D during ceramide-induced apoptosis in rat C6 glial cells.
Journal of neurochemistry 1997;69(2):713-20.
1997: H Sakai; Shigeru Nakashima; S Yoshimura; Y Nishimura; N Sakai; Yoshinori Nozawa
Identification of differentially expressed mRNAs during rat C6 glial cell differentiation by mRNA fingerprinting using arbitrarily primed PCR (RAP).
Neuroscience letters 1997;229(2):93-6.
1997: F Mirbod; Shigeru Nakashima; Y Kitajima; R D Cannon; Yoshinori Nozawa
Molecular cloning of a Rho family, CDC42Ca gene from Candida albicans and its mRNA expression changes during morphogenesis.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1997;35(3):173-9.
1997: Shin ichi Yoshimura; H Sakai; Shigeru Nakashima; Yoshinori Nozawa; Jun Shinoda; Noboru Sakai; H Yamada
Differential expression of Rho family GTP-binding proteins and protein kinase C isozymes during C6 glial cell differentiation.
Brain research. Molecular brain research 1997;45(1):90-8.
1997: Kenji Ohguchi; Shigeru Nakashima; Zhiming Tan; Yoshiko Banno; Shuji Dohi; Yoshinori Nozawa
Increased activity of small GTP-binding protein-dependent phospholipase D during differentiation in human promyelocytic leukemic HL60 cells.
The Journal of biological chemistry 1997;272(3):1990-6.
1997: H Sakai; Shigeru Nakashima; K Nakatani; Shin ichi Yoshimura; Y Nishimura; Noboru Sakai; Yoshinori Nozawa
Messenger RNA fingerprinting analysis using arbitrarily primed PCR (RAP) of genes expressed during rat C6 glioma cell differentiation.
Brain tumor pathology 1997;14(2):119-23.
1997: Shigeru Nakashima; Y Matsuda; Yukihiro Akao; Shinichi Yoshimura; H Sakai; K Hayakawa; M Andoh; Yoshinori Nozawa
Molecular cloning and chromosome mapping of rat phospholipase D genes, Pld1a, Pld1b and Pld2.
Cytogenetics and cell genetics 1997;79(1-2):109-13.
1997: M Kimura; T Hattori; Y Matsuda; Takashi Yoshioka; N Sumi; Y Umeda; Shigeru Nakashima; Yukio Okano
cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme.
Cytogenetics and cell genetics 1997;78(2):107-11.
1997: Y Ito; Shigeru Nakashima; H Kanoh; Yoshinori Nozawa
Implication of Ca(2+)-dependent protein tyrosine phosphorylation in carbachol-induced phospholipase D activation in rat pheochromocytoma PC12 cells.
Journal of neurochemistry 1997;68(1):419-25.
1996: F Mirbod; Shigeru Nakashima; Yasuo Kitajima; M A Ghannoum; R D Cannon; Yoshinori Nozawa
Molecular cloning of a gene encoding translation initiation factor (TIF) from Candida albicans.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1996;34(6):393-400.
1996: T Adachi; Shigeru Nakashima; Shigetoyo Saji; T Nakamura; Yoshinori Nozawa
Phospholipase D activation in hepatocyte growth factor-stimulated rat hepatocytes mediates the expressions of c-jun and c-fos: involvement of protein tyrosine kinase, protein kinase C, and Ca2+.
Hepatology (Baltimore, Md.) 1996;24(5):1274-81.
1996: Kenji Ohguchi; Yoshiko Banno; Shigeru Nakashima; Naoki Kato; K Watanabe; D M Lyerly; Yoshinori Nozawa
Effects of Clostridium difficile toxin A and toxin B on phospholipase D activation in human promyelocytic leukemic HL60 cells.
Infection and immunity 1996;64(11):4433-7.
1996: Yoshiko Banno; Y Ito; K Ojio; H Kanoh; Shigeru Nakashima; Yoshinori Nozawa
Membrane-associated phospholipase D activity in neural cell line PC12.
Journal of lipid mediators and cell signalling 1996;14(1-3):237-43.
1996: S Yoshimura; Shigeru Nakashima; Kenji Ohguchi; H Sakai; J Shinoda; Noboru Sakai; Yoshinori Nozawa
Differential mRNA expression of phospholipase D (PLD) isozymes during cAMP-induced differentiation in C6 glioma cells.
Biochemical and biophysical research communications 1996;225(2):494-9.
1996: T Kumada; Shigeru Nakashima; Y Nakamura; H Miyata; Yoshinori Nozawa
Phenylarsine oxide (PAO)-mediated activation of phospholipase D in rat basophilic leukemia (RBL-2H3) cells: possible involvement of calcium and protein kinase C.
Immunobiology 1996;195(3):347-59.
1996: K Ojio; Yoshiko Banno; Shigeru Nakashima; Naoki Kato; K Watanabe; D M Lyerly; H Miyata; Yoshinori Nozawa
Effect of Clostridium difficile toxin B on IgE receptor-mediated signal transduction in rat basophilic leukemia cells: inhibition of phospholipase D activation.
Biochemical and biophysical research communications 1996;224(2):591-6.
1996: Y Nakamura; Shigeru Nakashima; T Kumada; K Ojio; H Miyata; Yoshinori Nozawa
Brefeldin A inhibits antigen- or calcium ionophore-mediated but not PMA-induced phospholipase D activation in rat basophilic leukemia (RBL-2H3) cells.
Immunobiology 1996;195(2):231-42.
1996: M S Alam; Shigeru Nakashima; Y Deyashiki; Yoshiko Banno; A Hara; Yoshinori Nozawa
Molecular cloning of a gene encoding acid alpha-glucosidase from Tetrahymena pyriformis.
The Journal of eukaryotic microbiology 1996;43(4):295-303.
1996: Shigeru Nakashima; Y Zhao; Yoshinori Nozawa
Molecular cloning of delta 9 fatty acid desaturase from the protozoan Tetrahymena thermophila and its mRNA expression during thermal membrane adaptation.
The Biochemical journal 1996;317 ( Pt 1)():29-34.
1996: Yoshiko Banno; Shigeru Nakashima; M Ohzawa; Yoshinori Nozawa
Differential translocation of phospholipase C isozymes to integrin-mediated cytoskeletal complexes in thrombin-stimulated human platelets.
The Journal of biological chemistry 1996;271(25):14989-94.
1996: H Sakai; Shigeru Nakashima; S Yoshimura; K Nakatani; J Shinoda; Noboru Sakai; H Yamada; Yoshinori Nozawa
Suppressed expression of CD44 variant isoforms during human glioma A172 cell differentiation induced by cyclic AMP.
Neuroscience letters 1996;210(3):189-92.
1996: T Adachi; Shigeru Nakashima; Shigetoyo Saji; T Nakamura; Yoshinori Nozawa
Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: involvement of protein tyrosine kinase and protein kinase C.
Hepatology (Baltimore, Md.) 1996;23(5):1244-53.
1996: B Liu; Shigeru Nakashima; S Ito; Yoshinori Nozawa
PLD activation in Chinese hamster ovary (CHO) cells transfected with PGF2 alpha receptor cDNA.
Prostaglandins 1996;51(4):233-48.
1996: Kenji Ohguchi; Yoshiko Banno; Shigeru Nakashima; Yoshinori Nozawa
Regulation of membrane-bound phospholipase D by protein kinase C in HL60 cells. Synergistic action of small GTP-binding protein RhoA.
The Journal of biological chemistry 1996;271(8):4366-72.
1996: Shigeru Nakashima; Y Iwasaki; T Mizutani; Kenji Ohguchi; K Nagata; Yasuo Kitajima; Yoshinori Nozawa
Differential expression of protein kinase C isozymes and small GTP-binding proteins during HL60 cell differentiation by retinoic acid and cyclic AMP: relation with phospholipase D (PLD) activation.
Immunobiology 1996;196(5):588-98.
1996: Y Nakamura; Shigeru Nakashima; K Ojio; Yoshiko Banno; H Miyata; Yoshinori Nozawa
Ceramide inhibits IgE-mediated activation of phospholipase D, but not of phospholipase C, in rat basophilic leukemia (RBL-2H3) cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(1):256-62.
1995: K Ojio; Y Nakamura; H Miyata; Yoshiko Banno; Shigeru Nakashima; Yoshinori Nozawa
[The involvement of protein kinase C isozymes in activation of phospholipase D and secretion of serotonin in rat basophilic leukemia cells].
Arerugī = [Allergy] 1995;44(12):1410-7.
1995: Shigeru Nakashima; T Mizutani; Y Nakamura; S O Takemura; M Nakamura; H Miyata; Y Katagiri; Yoshinori Nozawa
Effects of selective phosphodiesterase type IV inhibitor, rolipram, on signal transducing phospholipases in neutrophil: inhibition of phospholipases A2, D but not C.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1995;112(2):137-43.
1995: B Liu; Shigeru Nakashima; T Takano; T Shimizu; Yoshinori Nozawa
Implication of protein kinase C alpha in PAF-stimulated phospholipase D activation in Chinese hamster ovary (CHO) cells expressing PAF receptor.
Biochemical and biophysical research communications 1995;214(2):418-23.
1995: T Kumada; Shigeru Nakashima; Y Nakamura; H Miyata; Yoshinori Nozawa
Antigen-mediated phospholipase D activation in rat basophilic leukemia (RBL-2H3) cells: possible involvement of calcium/calmodulin.
Biochimica et biophysica acta 1995;1258(2):107-14.
1995: F Mirbod; Yoshiko Banno; M A Ghannoum; Ashraf S Ibrahim; Shigeru Nakashima; Yasuo Kitajima; Garry T Cole; Yoshinori Nozawa
Purification and characterization of lysophospholipase-transacylase (h-LPTA) from a highly virulent strain of Candida albicans.
Biochimica et biophysica acta 1995;1257(2):181-8.
1995: Shigeru Nakashima; Yoshiko Banno; T Watanabe; Y Nakamura; T Mizutani; H Sakai; Y Zhao; Y Sugimoto; Yoshinori Nozawa
Deletion and site-directed mutagenesis of EF-hand domain of phospholipase C-delta 1: effects on its activity.
Biochemical and biophysical research communications 1995;211(2):365-9.
1995: Kenji Ohguchi; Yoshiko Banno; Shigeru Nakashima; Yoshinori Nozawa
Activation of membrane-bound phospholipase D by protein kinase C in HL60 cells: synergistic action of a small GTP-binding protein RhoA.
Biochemical and biophysical research communications 1995;211(1):306-11.
1995: Y Nakamura; Shigeru Nakashima; H Fujimiya; T Kumada; K Ojio; H Miyata; Yoshinori Nozawa
[Effects of antiallergic drug, pemirolast potassium on phospholipase D activation in antigen-stimulated rat basophilic leukemia (RBL-2H3) cells].
Arerugī = [Allergy] 1995;44(6):624-9.
1995: T Adachi; Shigeru Nakashima; Shigetoyo Saji; T Nakamura; Yoshinori Nozawa
Roles of prostaglandin production and mitogen-activated protein kinase activation in hepatocyte growth factor-mediated rat hepatocyte proliferation.
Hepatology (Baltimore, Md.) 1995;21(6):1668-74.
1995: Shigeru Nakashima; Yoshiko Banno; Yoshinori Nozawa
[Roles of phospholipase D in cell functions and its regulatory mechanisms].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1995;40(7):877-88.
1995: Yoshiko Banno; Shigeru Nakashima; T Hachiya; Yoshinori Nozawa
Endogenous cleavage of phospholipase C-beta 3 by agonist-induced activation of calpain in human platelets.
The Journal of biological chemistry 1995;270(9):4318-24.
1995: M S Alam; Yoshiko Banno; Shigeru Nakashima; Yoshinori Nozawa
Defective phospholipase D activation in Ki-ras-transformed NIH3T3 cells: evidence for downstream effector of PLC-gamma 1 in PDGF-mediated signal transduction.
Biochemical and biophysical research communications 1995;207(1):460-6.
1995: Shigeru Nakashima; Yoshinori Nozawa; S Kudo
[Inositol].
Nihon rinsho. Japanese journal of clinical medicine 1995;53 Su Pt 1():738-41.
1995: Y Nakamura; Shigeru Nakashima; H Fujimiya; T Kumada; Y Kato; H Miyata; Yoshinori Nozawa
Effects of an antiallergic drug, pemirolast potassium on tyrosine phosphorylation and map kinase activation in antigen-stimulated rat basophilic leukemia (RBL-2H3) cells.
Arerugī = [Allergy] 1995;44(1):34-44.
1994: B Liu; Shigeru Nakashima; H Kanoh; T Takano; T Shimizu; Yoshinori Nozawa
Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor.
Journal of biochemistry 1994;116(4):882-91.
1994: T Kumada; Shigeru Nakashima; H Miyata; Yoshinori Nozawa
Potent activation of phospholipase D by phenylarsine oxide in rat basophilic leukemia (RBL-2H3) cells.
Biochemical and biophysical research communications 1994;199(2):792-8.
1994: H Fujimiya; Shigeru Nakashima; T Kumada; Y Nakamura; H Miyata; Yoshinori Nozawa
An antiallergic drug, pemirolast potassium, inhibits inositol 1,4,5-trisphosphate production and Ca2+ mobilization in antigen-stimulated rat basophilic leukemia (RBL-2H3) cells.
Arerugī = [Allergy] 1994;43(2 Pt 1):142-51.
1994: Shigeru Nakashima; Y Chatani; M Nakamura; N Miyoshi; Michiaki Kohno; Yoshinori Nozawa
Tyrosine phosphorylation and activation of mitogen-activated protein kinases by thrombin in human platelets: possible involvement in late arachidonic acid release.
Biochemical and biophysical research communications 1994;198(2):497-503.
1994: T Suzuki; Shigeru Nakashima; Yoshinori Nozawa
Regulation of Phosphatidylinositol 4-phosphate 5-kinase by Protein Kinase C in Human Platelet Membranes.
Platelets 1994;5(6):336-42.
1994: T Suzuki; Shigeru Nakashima; Yoshinori Nozawa
Inhibition of Phosphatidylinositol 4-phosphate 5-kinase by Cyclic AMP in Human Platelets.
Platelets 1994;5(5):258-65.
1993: H Fujimiya; H Miyata; Shigeru Nakashima; Yoshinori Nozawa
[IgE-receptor stimulation induces biphasic 1,2-diacylglycerol production in RBL-2H3 cells. Phosphatidylcholine hydrolysis by phospholipase D plays a major role in the second sustained 1,2-diacylglycerol accumulation].
Arerugī = [Allergy] 1993;42(1):64-73.
1992: A Suganuma; Shigeru Nakashima; Yukio Okano; Yoshinori Nozawa
Mass contents of inositol 1,4,5-trisphosphate and 1,2-diacylglycerol in human platelets stimulated with a thromboxane analogue and thrombin.
Thrombosis and haemostasis 1992;68(3):341-5.
1992: S Osada; Shigeru Nakashima; Shigetoyo Saji; T Nakamura; Yoshinori Nozawa
Hepatocyte growth factor (HGF) mediates the sustained formation of 1,2-diacylglycerol via phosphatidylcholine-phospholipase C in cultured rat hepatocytes.
FEBS letters 1992;297(3):271-4.
1991: Shigeru Nakashima; Yoshinori Nozawa
[Inhibitors for enzymes involving arachidonate cascade].
Nihon rinsho. Japanese journal of clinical medicine 1991;49(9):1984-92.
1991: Shigeru Nakashima; H Fujimiya; H Miyata; Yoshinori Nozawa
Antigen-induced biphasic diacylglycerol formation in RBL-2H3 cells: the late sustained phase due to phosphatidylcholine hydrolysis is dependent on protein kinase C.
Biochemical and biophysical research communications 1991;177(1):336-42.
1991: Shigeru Nakashima; A Suganuma; A Matsui; Yoshinori Nozawa
Thrombin induces a biphasic 1,2-diacylglycerol production in human platelets.
The Biochemical journal 1991;275 ( Pt 2)():355-61.
1991: Yoshinori Nozawa; Shigeru Nakashima; K Nagata
Phospholipid-mediated signaling in receptor activation of human platelets.
Biochimica et biophysica acta 1991;1082(3):219-38.
1991: Shigeru Nakashima; T Koike; Yoshinori Nozawa
Genistein, a protein tyrosine kinase inhibitor, inhibits thromboxane A2-mediated human platelet responses.
Molecular pharmacology 1991;39(4):475-80.
1991: Shigeru Nakashima; T Fu; H Hattori
[Biphasic diacylglycerol formation in agonist-stimulated cells and its physiological functions].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1991;36(3):650-6.
1991: Tatsuo Ishizuka; Keigo Yasuda; N Takeda; Kazuo Kajita; K Miura; Shigeru Nakashima; S Nagao; Yoshinori Nozawa
Thrombin-induced breakdown of phosphoinositides in platelets from patients with NIDDM.
Endocrinologia japonica 1991;38(1):81-7.
1991: H Fujimiya; Shigeru Nakashima; H Miyata; Yoshinori Nozawa
Effect of a novel antiallergic drug, pemirolast, on activation of rat peritoneal mast cells: inhibition of exocytotic response and membrane phospholipid turnover.
International archives of allergy and applied immunology 1991;96(1):62-7.
1989: H Kaiya; A Nishida; Atsushi Imai; Shigeru Nakashima; Yoshinori Nozawa
Accumulation of diacylgylcerol in platelet phosphoinositide turnover in schizophrenia: a biological marker of good prognosis?
Biological psychiatry 1989;26(7):669-76.
1989: T Tohmatsu; A Nishida; S Nagao; Shigeru Nakashima; Yoshinori Nozawa
Inhibitory action of cyclic AMP on inositol 1,4,5-trisphosphate-induced Ca2+ release in saponin-permeabilized platelets.
Biochimica et biophysica acta 1989;1013(2):190-3.
1989: Shigeru Nakashima; A Suganuma; M Sato; T Tohmatsu; Yoshinori Nozawa
Mechanism of arachidonic acid liberation in platelet-activating factor-stimulated human polymorphonuclear neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(4):1295-302.
1989: T Tohmatsu; Shigeru Nakashima; Yoshinori Nozawa
Evidence of Ca2+ mobilizing action of arachidonic acid in human platelets.
Biochimica et biophysica acta 1989;1012(1):97-102.
1989: Shigeru Nakashima; A Suganuma; A Matsui; H Hattori; M Sato; A Takenaka; Yoshinori Nozawa
Primary role of calcium ions in arachidonic acid release from rat platelet membranes. Comparison with human platelet membranes.
The Biochemical journal 1989;259(1):139-44.
1988: Shigeru Nakashima; K Nagata; K Ueeda; Yoshinori Nozawa
Stimulation of arachidonic acid release by guanine nucleotide in saponin-permeabilized neutrophils: evidence for involvement of GTP-binding protein in phospholipase A2 activation.
Archives of biochemistry and biophysics 1988;261(2):375-83.
1987: Shigeru Nakashima; H Hattori; L Shirato; A Takenaka; Yoshinori Nozawa
Differential sensitivity of arachidonic acid release and 1,2-diacylglycerol formation to pertussis toxin, GDP beta S and NaF in saponin-permeabilized human platelets: possible evidence for distinct GTP-binding proteins involving phospholipase C and A2 activation.
Biochemical and biophysical research communications 1987;148(3):971-8.
1987: T Tohmatsu; Shigeru Nakashima; H Hattori; A Suganuma; Yoshinori Nozawa
A role of diacylglycerol kinase in stimulus-secretion coupling of human platelets. Dissociation of serotonin secretion from Ca2+ mobilization.
Thrombosis research 1987;47(1):25-35.
1987: Shigeru Nakashima; T Tohmatsu; H Hattori; A Suganuma; Yoshinori Nozawa
Guanine nucleotides stimulate arachidonic acid release by phospholipase A2 in saponin-permeabilized human platelets.
Journal of biochemistry 1987;101(4):1055-8.
1986: Yoshiko Banno; Shigeru Nakashima; T Tohmatsu; Yoshinori Nozawa; E G Lapetina
GTP and GDP will stimulate platelet cytosolic phospholipase C independently of Ca2+.
Biochemical and biophysical research communications 1986;140(2):728-34.