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Iwao Nakatsuka

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Yoshitaka Tomigahara; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
Metabolism of N-[(R)-1-(2,4-dichlorophenyl)ethyl]-2-cyano-3,3-dimethylbutanamide (Delaus, S-2900) and its isomer, N-[(S)-1-(2,4-dichlorophenyl)ethyl]-2-cyano-3,3-dimethylbutanamide (S-2900S), in rats. 1. Identification of metabolites in feces and urine.
Yumiko Nakayama; Fumio Kishida; Iwao Nakatsuka; Masatoshi Matsuo
Simulation of the toxicokinetics of trichloroethylene, methylene chloride, styrene and n-hexane by a toxicokinetics/toxicodynamics model using experimental data.
Kiyoshi Higashi; Yutaka Inagaki; Ko Fujimori; Atsuhito Nakao; Hideo Kaneko; Iwao Nakatsuka
Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3.

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2006: Yoshitaka Tomigahara; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
Metabolism of N-[(R)-1-(2,4-dichlorophenyl)ethyl]-2-cyano-3,3-dimethylbutanamide (Delaus, S-2900) and its isomer, N-[(S)-1-(2,4-dichlorophenyl)ethyl]-2-cyano-3,3-dimethylbutanamide (S-2900S), in rats. 1. Identification of metabolites in feces and urine.
Journal of agricultural and food chemistry 2006;54(12):4333-42.
2005: Yumiko Nakayama; Fumio Kishida; Iwao Nakatsuka; Masatoshi Matsuo
Simulation of the toxicokinetics of trichloroethylene, methylene chloride, styrene and n-hexane by a toxicokinetics/toxicodynamics model using experimental data.
Environmental sciences : an international journal of environmental physiology and toxicology 2005;12(1):21-32.
2003: Kiyoshi Higashi; Yutaka Inagaki; Ko Fujimori; Atsuhito Nakao; Hideo Kaneko; Iwao Nakatsuka
Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3.
The Journal of biological chemistry 2003;278(44):43470-9.
2003: Kiyoshi Higashi; Yutaka Inagaki; Noriyuki Suzuki; Shinichi Mitsui; Alain Mauviel; Hideo Kaneko; Iwao Nakatsuka
Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma.
The Journal of biological chemistry 2003;278(7):5156-62.
2003: Yoshiko Mizuno; Naoko Tani; Setsuko Komuro; Hiroshi Kanamaru; Iwao Nakatsuka
In vitro metabolism of perospirone in rat, monkey and human liver microsomes.
European journal of drug metabolism and pharmacokinetics 2003;28(1):59-65.
2003: Masashi Yabuki; Yutaka Kon-Ya; Masaki Kataoka; Takeshi Shimizudani; Kyoko Akao; Masaki Ito; Hiroshi Kanamaru; Iwao Nakatsuka
Pharmacokinetics of a novel N-methyl-D-aspartate receptor antagonist (SM-18400): identification of an N-acetylated metabolite and pre-clinical assessment of N-acetylation polymorphism.
European journal of drug metabolism and pharmacokinetics 2003;28(1):21-9.
2002: Ryozo Tsuji; Kumiko Kobayashi; Maya Ikeda; Takafumi Yoshioka; Tomoya Yamada; Takaki Seki; Yasuyoshi Okuno; Iwao Nakatsuka; Yoshihiro Tsuruo; Shiroh Kishioka
Lack of changes in brain muscarinic receptor and motor activity of mice after neonatal inhalation exposure to d-allethrin.
Journal of applied toxicology : JAT 2002;22(6):423-9.
2002: Takeshi Kunimatsu; Tomoya Yamada; Keiko Ose; Osamu Sunami; Yusuke Kamita; Yasuyoshi Okuno; Takaki Seki; Iwao Nakatsuka
Lack of (anti-) androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays.
Regulatory toxicology and pharmacology : RTP 2002;35(2 Pt 1):227-37.
2001: Tomoya Yamada; Osamu Sunami; Takeshi Kunimatsu; Yusuke Kamita; Yasuyoshi Okuno; Takaki Seki; Iwao Nakatsuka; Masatoshi Matsuo
Dissection and weighing of accessory sex glands after formalin fixation, and a 5-day assay using young mature rats are reliable and feasible in the Hershberger assay.
Toxicology 2001;162(2):103-19.
2001: Kayo Sumida; Norihisa Ooe; H Nagahori; Koichi Saito; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
An in vitro reporter gene assay method incorporating metabolic activation with human and rat S9 or liver microsomes.
Biochemical and biophysical research communications 2001;280(1):85-91.
2001: Kayo Sumida; Koichi Saito; Norihisa Ooe; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
Evaluation of in vitro methods for detecting the effects of various chemicals on the human progesterone receptor, with a focus on pyrethroid insecticides.
Toxicology letters 2001;118(3):147-55.
2000: Osamu Sunami; Takeshi Kunimatsu; Tomoya Yamada; Setsuko Yabushita; Tokuo Sukata; Kaori Miyata; Yusuke Kamita; Yasuyoshi Okuno; Takaki Seki; Iwao Nakatsuka; Masatoshi Matsuo
Evaluation of a 5-day Hershberger assay using young mature male rats: methyltestosterone and p,p'-DDE, but not fenitrothion, exhibited androgenic or antiandrogenic activity in vivo.
The Journal of toxicological sciences 2000;25(5):403-15.
2000: H Nagahori; H Yoshino; Yoshitaka Tomigahara; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
Metabolism of furametpyr. 2. (14)C excretion, (14)C concentrations in tissues, and amounts of metabolites in rats.
Journal of agricultural and food chemistry 2000;48(11):5760-7.
2000: H Nagahori; H Yoshino; Yoshitaka Tomigahara; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
Metabolism of furametpyr. 1. Identification of metabolites and in vitro biotransformation in rats and humans.
Journal of agricultural and food chemistry 2000;48(11):5754-9.
2000: Koichi Saito; Yoshitaka Tomigahara; N Ohe; Naohiko Isobe; Iwao Nakatsuka; Hideo Kaneko
Lack of significant estrogenic or antiestrogenic activity of pyrethroid insecticides in three in vitro assays based on classic estrogen receptor alpha-mediated mechanisms.
Toxicological sciences : an official journal of the Society of Toxicology 2000;57(1):54-60.
2000: Yoshitaka Tomigahara; M Onogi; Koichi Saito; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka
Metabolism of Cyanox in rat. II. Sex-related differences in oxidative dearylation and desulphuration.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(4):395-406.
2000: N Tsushima; Masashi Yabuki; H Harada; T Katsumata; Hiroshi Kanamaru; Iwao Nakatsuka; M Yamamoto; M Nakatsuka
Tissue distribution and pharmacological potential of SM-16896, a novel oestrogen-bisphosphonate hybrid compound.
The Journal of pharmacy and pharmacology 2000;52(1):27-37.
1999: Yoshitaka Tomigahara; M Onogi; Hideo Kaneko; Iwao Nakatsuka; S Yamane
Metabolism of 7-fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4- (2-propynyl)-2H-1,4-benzoxazin-3(4H)-one (S-53482, flumioxazin) in the rat: II. Identification of reduced metabolites.
Journal of agricultural and food chemistry 1999;47(6):2429-38.
1999: Setsuko Komuro; M Sato; Hiroshi Kanamaru; Hideo Kaneko; Iwao Nakatsuka; A Yoshitake
In vivo and in vitro pharmacokinetics and metabolism studies of 26,26,26,27,27,27-F6-1,25(OH)2 vitamin D3 (Falecalcitriol) in rat: induction of vitamin D3-24-hydroxylase (CYP24) responsible for 23S-hydroxylation in target tissues and the drop in serum levels.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(6):603-13.
1999: Yoshitaka Tomigahara; M Matsui; H Matsunaga; Naohiko Isobe; Hideo Kaneko; Iwao Nakatsuka; A Yoshitake; S Yamane
Metabolism of 7-fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4- (2-propynyl)-2H-1,4-benzoxazin-3(4H)-one (S-53482) in rat. 1. Identification of a sulfonic acid type conjugate.
Journal of agricultural and food chemistry 1999;47(1):305-12.
1998: Setsuko Komuro; Hiroshi Kanamaru; Iwao Nakatsuka; A Yoshitake
Distribution and metabolism of F6-1,25(OH)2 vitamin D3 and 1,25(OH)2 vitamin D3 in the bones of rats dosed with tritium-labeled compounds.
Steroids 1998;63(10):505-10.
1998: Y Nakamura; T Higaki; Hiroshi Kato; Fumio Kishida; Iwao Nakatsuka
Comparison of sex differences in guinea-pig maximization test for detection of skin-sensitizing potential using OECD recommended positive control sensitizers.
The Journal of toxicological sciences 1998;23(2):105-11.
1997: T Yamada; K Odawara; Fumio Kishida; Iwao Nakatsuka; A Yoshitake
Development of a novel CHL/IU cell line with an incorporated gpt shuttle vector for concurrent analysis of gene mutations and chromosome aberrations.
Mutation research 1997;393(3):295-306.
1997: Yoshitaka Tomigahara; M Onogi; Koichi Saito; Hideo Kaneko; Iwao Nakatsuka; S Yamane
Metabolism of tetramethrin isomers in rat: IV. Tissues responsible for formation of reduced and hydrated metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(9):961-71.
1997: K Odawara; K Yamamoto; Hiroshi Kato; M Hara; S Kogiso; Fumio Kishida; A Yoshitake; Iwao Nakatsuka
A new semi-automated chromosome analysis system for in vitro chromosomal aberration tests.
Mutation research 1997;389(2-3):207-12.
1997: Masashi Yabuki; Jin Shimakura; M Ito; Hiroshi Kanamaru; K Iba; Iwao Nakatsuka
Metabolism of 4-[1-(2-fluoro-4-biphenylyl)ethyl]-2-methylaminothiazole (SM-8849) in rats.
European journal of drug metabolism and pharmacokinetics 1997;22(1):25-33.
1996: Y Nakamura; Hiroshi Kato; Fumio Kishida; S Kogiso; Iwao Nakatsuka
[Effect of fenitrothion on experimental allergic conjunctivitis].
The Journal of toxicological sciences 1996;21 Suppl 3():485-93.
1996: Yoshitaka Tomigahara; M Onogi; M Miki; K Yanagi; K Shiba; Hideo Kaneko; Iwao Nakatsuka; H Yamada
Metabolism of tetramethrin isomers in rat. III. Stereochemistry of reduced metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(2):201-10.
1996: K Komai; K Sumida; H Kaneko; Iwao Nakatsuka
Identification of a new non-functional CYP2C18 allele in Japanese: substitution of T204 to A in exon2 generates a premature stop codon.
Pharmacogenetics 1996;6(1):117-9.
1996: K Saito; S Uwagawa; Hideo Kaneko; K Shiba; Yoshitaka Tomigahara; Iwao Nakatsuka
Alpha 2u-globulins in the urine of male rats: a reliable indicator for alpha 2u-globulin accumulation in the kidney.
Toxicology 1996;106(1-3):149-57.
1995: Yoshitaka Tomigahara; M Onogi; K Saito; K Shiba; Hideo Kaneko; Iwao Nakatsuka; H Yamada
Metabolism of Cyanox in the rat. I. Absorption, disposition, excretion and biotransformation.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(11):1195-206.
1994: Yoshitaka Tomigahara; M Mori; K Shiba; N Isobe; Hideo Kaneko; Iwao Nakatsuka; H Yamada
Metabolism of tetramethrin isomers in rat: II. Identification and quantitation of metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(12):1205-14.
1994: Yoshitaka Tomigahara; K Shiba; N Isobe; Hideo Kaneko; Iwao Nakatsuka; H Yamada
Identification of two new types of S-linked conjugates of Etoc in rat.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(9):839-52.
1994: Yoshitaka Tomigahara; M Mori; K Shiba; N Isobe; Hideo Kaneko; Iwao Nakatsuka; H Yamada
Metabolism of tetramethrin isomers in rat. I. Identification of a sulphonic acid type of conjugate and reduced metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(5):473-84.
1994: M Yabuki; T Mine; K Iba; Iwao Nakatsuka; A Yoshitake
Pharmacokinetics of SM-10888 and its metabolites depending on their physicochemical properties.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(2):294-7.
1994: Yasuhiko Iida; Hideo Saji; Yasuhiro Magata; Junji Konishi; Iwao Nakatsuka; A Yoshitake; A Yokoyama
11C-labeled 2'-iododiazepam for PET studies of benzodiazepine receptors: synthesis and comparison of biodistribution with its radioiodinated compound.
Annals of nuclear medicine 1994;8(1):17-22.
1994: Hideo Saji; Yasuhiko Iida; Iwao Nakatsuka; M Kataoka; T Miyao; K Ariyoshi; Yasuhiro Magata; A Yoshitake; A Yokoyama
Radioiodinated nordiazepam analog for in vivo assessment of benzodiazepine receptors by single photon emission tomography.
Nuclear medicine and biology 1994;21(1):57-62.
1994: Setsuko Komuro; Iwao Nakatsuka; A Yoshitake; K Iba
Quantitative determination of F6-1,25(OH)2 vitamin D3 in human serum by gas chromatography/mass spectrometry with high-resolution selected ion monitoring.
Biological mass spectrometry 1994;23(1):33-8.
1993: M Yabuki; T Mine; K Iba; Iwao Nakatsuka; A Yoshitake
Metabolism of a tetrahydroaminoacridine derivative (SM-10888) in rat: structural analysis of an N-glucuronide of SM-10888 and an O-glucuronide of hydroxylated SM-10888 by FAB-MS/MS.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(12):1367-75.
1993: M Yabuki; F Shono; Iwao Nakatsuka; A Yoshitake
Novel cleavage of the 1,2,4-oxadiazole ring in rat metabolism of SM-6586, a dihydropyridine calcium antagonist.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):1167-9.
1993: H Yoshino; Hideo Kaneko; Iwao Nakatsuka; H Yamada
Metabolism of N-[4-chloro-2-fluoro-5-[(1-methyl-2-propynyl)oxy]phenyl]-3,4,5,6- tetrahydrophthalimide (S-23121) in the rat. II. Absorption, disposition, excretion and biotransformation.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(10):1075-84.
1993: Hideo Saji; Yasuhiko Iida; Iwao Nakatsuka; M Kataoka; K Ariyoshi; Yasuhiro Magata; A Yoshitake; A Yokoyama
Radioiodinated 2'-iododiazepam: a potential imaging agent for SPECT investigations of benzodiazepine receptors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993;34(6):932-7.
1993: H Yoshino; H Matsunaga; Hideo Kaneko; A Yoshitake; Iwao Nakatsuka; H Yamada
Metabolism of N-[4-chloro-2-fluoro-5-[(1-methyl-2- propynl)oxy]phenyl]-3,4,5,6-tetrahydrophthalimide (S-23121) in the rat: I. Identification of a new, sulphonic acid type of conjugate.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(6):609-19.
1993: Hideo Saji; Yasuhiko Iida; K Ariyoshi; Iwao Nakatsuka; M Kataoka; A Yoshitake; A Yokoyama
An approach for assaying benzodiazepine receptor binding with radioiodinated ligand: 125I-labeled diazepam derivative.
Biological & pharmaceutical bulletin 1993;16(5):513-5.
1992: K Saito; Hideo Kaneko; N Isobe; Iwao Nakatsuka; A Yoshitake; H Yamada
Differences in alpha 2u-globulins increased in male rat kidneys following treatment with several alpha 2u-globulin accumulating agents: cystein protease(s) play(s) an important role in production of kidney-type-alpha 2u-globulin.
Toxicology 1992;76(2):177-86.
1992: Hideo Saji; Yasuhiko Iida; Yasuhiro Magata; Yoshiharu Yonekura; Y Iwasaki; S Sasayama; Junji Konishi; Iwao Nakatsuka; K Shiba; A Yoshitake
Preparation of 123I-labeled 2'-iodospiperone and imaging of D2 dopamine receptors in the human brain using SPECT.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992;19(5):523-9.
1992: Hideo Saji; T Tokui; Iwao Nakatsuka; A Saiga; Yasuhiro Magata; K Shiba; A Yoshitake; A Yokoyama
Evaluation of N-alkyl derivatives of radioiodinated spiperone as radioligands for in vivo dopamine D2 receptor studies: effects of lipophilicity and receptor affinity on the in vivo biodistribution.
Chemical & pharmaceutical bulletin 1992;40(1):165-9.
1988: K Nishioka; Iwao Nakatsuka; H Kanamaru
An improved method for 14C-labelling of farnesylacetic acid and its geranyl ester.
Radioisotopes 1988;37(3):133-9.
1987: Hideo Saji; Iwao Nakatsuka; K Shiba; T Tokui; K Horiuchi; A Yoshitake; K Torizuka; A Yokoyama
Radioiodinated 2'-iodospiperone: a new radioligand for in vivo dopamine receptor study.
Life sciences 1987;41(17):1999-2006.
1987: Iwao Nakatsuka; Hideo Saji; K Shiba; H Shimizu; M Okuno; A Yoshitake; A Yokoyama
In vitro evaluation of radioiodinated butyrophenones as radiotracer for dopamine receptor study.
Life sciences 1987;41(17):1989-97.
1985: H Kanamaru; Iwao Nakatsuka; A Yoshitake
Application of gas chromatograph-mass spectrometer-computer system to evaluation of 14C-labelled compounds.
Radioisotopes 1985;34(8):401-7.
1985: H Kanamaru; R Takai; M Horiba; Iwao Nakatsuka; A Yoshitake
A method for measuring specific activities of 14C-labelled compounds by gas chromatography-mass spectrometry-computer system.
Radioisotopes 1985;34(2):67-71.
1985: Iwao Nakatsuka; H Shimizu; Y Asami; T Katoh; A Hirose; A Yoshitake
Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity.
Life sciences 1985;36(2):113-9.
1982: A Yoshitake; H Gomi; Iwao Nakatsuka
14C-labelling of a new beta-adrenergic blocking agent (S-596).
Radioisotopes 1982;31(2):101-3.
1981: A Yoshitake; H Gomi; Iwao Nakatsuka
Preparation of tetramethylcyclopropanecarboxylic-14C acid and insecticidal terallethrin-14C from it.
Radioisotopes 1981;30(8):452-4.
1981: A Yoshitake; T Kamada; Iwao Nakatsuka
Synthesis of 14C labelled o,o-dimethyl o-(3-carboxy-4-nitrophenyl) phosphorothioate.
Radioisotopes 1981;30(7):394-6.
1980: H Gomi; Iwao Nakatsuka; A Yoshitake
14C-labelling of a hypocholesterolemic agents, N-(alpha-methylbenzyl) linoleamide.
Radioisotopes 1980;29(9):443-5.