Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

David Agard

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Physiology

Protein Folding

Anatomy

Procedures

Living Beings

Activities & Behaviors

Genes & Molecular Sequences

Amino Acid Sequence

Occupations

Thermodynamics

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
49
Sedat, John
11
Braunfeld, Michael
6
Sohl, Julie
6
marshall, wallace
5
Ota, Nobuyuki
5
Rice, Luke
5
Cande, Zacheus
5
Cunningham, Erin
5
Dernburg, Abby
4
Jaswal, Sheila
4
Alberts, Bruce
4
Belmont, Andrew
4
Paddy, Michael
4
Shiau, Andrew
4
Fung, Jennifer

Sign-in to see all Coauthors

Publications

TOP 3
Choy Rebeca M; Kollman Justin M; Zelter Alex; Davis Trisha N; Agard David A
Localization and orientation of the gamma-tubulin small complex components using protein tags as labels for single particle EM.
Zheng Shawn Q; Matsuda Atsushi; Braunfeld Michael B; Sedat John W; Agard David A
Dual-axis target mapping and automated sequential acquisition of dual-axis EM tomographic data.
Polka Jessica K; Kollman Justin M; Agard David A; Mullins R Dyche
The structure and assembly dynamics of plasmid actin AlfA imply a novel mechanism of DNA segregation.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of David Agard (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Choy Rebeca M; Kollman Justin M; Zelter Alex; Davis Trisha N; Agard David A
Localization and orientation of the gamma-tubulin small complex components using protein tags as labels for single particle EM.
Journal of structural biology 2009;168(3):571-4.
2009: Zheng Shawn Q; Matsuda Atsushi; Braunfeld Michael B; Sedat John W; Agard David A
Dual-axis target mapping and automated sequential acquisition of dual-axis EM tomographic data.
Journal of structural biology 2009;168(2):323-31.
2009: Polka Jessica K; Kollman Justin M; Agard David A; Mullins R Dyche
The structure and assembly dynamics of plasmid actin AlfA imply a novel mechanism of DNA segregation.
Journal of bacteriology 2009;191(20):6219-30.
2009: Krukenberg Kristin A; Böttcher Ulrike M K; Southworth Daniel R; Agard David A
Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide.
Protein science : a publication of the Protein Society 2009;18(9):1815-27.
2009: Krukenberg Kristin A; Southworth Daniel R; Street Timothy O; Agard David A
pH-dependent conformational changes in bacterial Hsp90 reveal a Grp94-like conformation at pH 6 that is highly active in suppression of citrate synthase aggregation.
Journal of molecular biology 2009;390(2):278-91.
2009: Ho Bosco K; Agard David A
Probing the flexibility of large conformational changes in protein structures through local perturbations.
PLoS computational biology 2009;5(4):e1000343.
2008: Southworth Daniel R; Agard David A
Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle.
Molecular cell 2008;32(5):631-40.
2008: Nölting Bengt; Agard David A
How general is the nucleation-condensation mechanism?
Proteins 2008;73(3):754-64.
2008: Förster Friedrich; Webb Benjamin; Krukenberg Kristin A; Tsuruta Hiro; Agard David A; Sali Andrej
Integration of small-angle X-ray scattering data into structural modeling of proteins and their assemblies.
Journal of molecular biology 2008;382(4):1089-106.
2008: Cunningham Christian N; Krukenberg Kristin A; Agard David A
Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90.
The Journal of biological chemistry 2008;283(30):21170-8.
2008: Schermelleh Lothar; Carlton Peter M; Haase Sebastian; Shao Lin; Winoto Lukman; Kner Peter; Burke Brian; Cardoso M Cristina; Agard David A; Gustafsson Mats G L; Leonhardt Heinrich; Sedat John W
Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy.
Science (New York, N.Y.) 2008;320(5881):1332-6.
2008: Gustafsson Mats G L; Shao Lin; Carlton Peter M; Wang C J Rachel; Golubovskaya Inna N; Cande W Zacheus; Agard David A; Sedat John W
Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination.
Biophysical journal 2008;94(12):4957-70.
2008: Shao Lin; Isaac Berith; Uzawa Satoru; Agard David A; Sedat John W; Gustafsson Mats G L
I5S: wide-field light microscopy with 100-nm-scale resolution in three dimensions.
Biophysical journal 2008;94(12):4971-83.
2008: Krukenberg Kristin A; Förster Friedrich; Rice Luke M; Sali Andrej; Agard David A
Multiple conformations of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90.
Structure (London, England : 1993) 2008;16(5):755-65.
2008: Trammell Matthew A; Mahoney Nicole M; Agard David A; Vale Ronald D
Mob4 plays a role in spindle focusing in Drosophila S2 cells.
Journal of cell science 2008;121(Pt 8):1284-92.
2008: Rice Luke M; Montabana Elizabeth A; Agard David A
The lattice as allosteric effector: structural studies of alphabeta- and gamma-tubulin clarify the role of GTP in microtubule assembly.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5378-83.
2008: Kollman Justin M; Zelter Alex; Muller Eric G D; Fox Bethany; Rice Luke M; Davis Trisha N; Agard David A
The structure of the gamma-tubulin small complex: implications of its architecture and flexibility for microtubule nucleation.
Molecular biology of the cell 2008;19(1):207-15.
2008: Ho Bosco K; Agard David A
Identification of new, well-populated amino-acid sidechain rotamers involving hydroxyl-hydrogen atoms and sulfhydryl-hydrogen atoms.
BMC structural biology 2008;8():41.
2007: König Peter; Braunfeld Michael B; Sedat John W; Agard David A
The three-dimensional structure of in vitro reconstituted Xenopus laevis chromosomes by EM tomography.
Chromosoma 2007;116(4):349-72.
2007: Kelch Brian A; Agard David A
Mesophile versus thermophile: insights into the structural mechanisms of kinetic stability.
Journal of molecular biology 2007;370(4):784-95.
2007: Hom Erik F Y; Marchis Franck; Lee Timothy K; Haase Sebastian; Agard David A; Sedat John W
AIDA: an adaptive image deconvolution algorithm with application to multi-frame and three-dimensional data.
Journal of the Optical Society of America. A, Optics, image science, and vision 2007;24(6):1580-600.
2007: Kelch Brian A; Eagen Kyle P; Erciyas F Pinar; Humphris Elisabeth L; Thomason Adam R; Mitsuiki Shinji; Agard David A
Structural and mechanistic exploration of acid resistance: kinetic stability facilitates evolution of extremophilic behavior.
Journal of molecular biology 2007;368(3):870-83.
2007: Kam Zvi; Kner Peter; Agard David; Sedat John W
Modelling the application of adaptive optics to wide-field microscope live imaging.
Journal of microscopy 2007;226(Pt 1):33-42.
2007: Zheng Shawn Q; Kollman Justin M; Braunfeld Michael B; Sedat John W; Agard David A
Automated acquisition of electron microscopic random conical tilt sets.
Journal of structural biology 2007;157(1):148-55.
2007: Zheng Shawn Q; Keszthelyi Bettina; Branlund Eric; Lyle John M; Braunfeld Michael B; Sedat John W; Agard David A
UCSF tomography: an integrated software suite for real-time electron microscopic tomographic data collection, alignment, and reconstruction.
Journal of structural biology 2007;157(1):138-47.
2006: Yonekura Koji; Braunfeld Michael B; Maki-Yonekura Saori; Agard David A
Electron energy filtering significantly improves amplitude contrast of frozen-hydrated protein at 300kV.
Journal of structural biology 2006;156(3):524-36.
2006: Shiau Andrew K; Harris Seth F; Southworth Daniel R; Agard David A
Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell 2006;127(2):329-40.
2006: Wei Bin; Lam Peter G; Braunfeld Michael B; Agard David A; Genzer Jan; Spontak Richard J
Tunable instability mechanisms of polymer thin films by molecular self-assembly.
Langmuir : the ACS journal of surfaces and colloids 2006;22(21):8642-5.
2006: Fuhrmann Cynthia N; Daugherty Matthew D; Agard David A
Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis.
Journal of the American Chemical Society 2006;128(28):9086-102.
2005: Truhlar Stephanie M E; Agard David A
The folding landscape of an alpha-lytic protease variant reveals the role of a conserved beta-hairpin in the development of kinetic stability.
Proteins 2005;61(1):105-14.
2005: Moss W C; Haase S; Lyle J M; Agard D A; Sedat J W
A novel 3D wavelet-based filter for visualizing features in noisy biological data.
Journal of microscopy 2005;219(Pt 2):43-9.
2005: Ota Nobuyuki; Agard David A
Intramolecular signaling pathways revealed by modeling anisotropic thermal diffusion.
Journal of molecular biology 2005;351(2):345-54.
2005: König Peter; Braunfeld Michael; Agard David A
Use of surface affinity enrichment and cryo-embedding to prepare in vitro reconstituted mitotic chromosomes for EM tomography.
Ultramicroscopy 2005;103(4):261-74.
2005: Aldaz Hector; Rice Luke M; Stearns Tim; Agard David A
Insights into microtubule nucleation from the crystal structure of human gamma-tubulin.
Nature 2005;435(7041):523-7.
2005: Jaswal Sheila S; Truhlar Stephanie M E; Dill Ken A; Agard David A
Comprehensive analysis of protein folding activation thermodynamics reveals a universal behavior violated by kinetically stable proteases.
Journal of molecular biology 2005;347(2):355-66.
2004: Uzawa Satoru; Li Fei; Jin Ye; McDonald Kent L; Braunfeld Michael B; Agard David A; Cande W Zacheus
Spindle pole body duplication in fission yeast occurs at the G1/S boundary but maturation is blocked until exit from S by an event downstream of cdc10+.
Molecular biology of the cell 2004;15(12):5219-30.
2004: MacDowell Alastair A; Celestre Rich S; Howells Malcolm; McKinney Wayne; Krupnick James; Cambie Daniella; Domning Edward E; Duarte Robert M; Kelez Nicholas; Plate David W; Cork Carl W; Earnest Thomas N; Dickert Jeffery; Meigs George; Ralston Corie; Holton James M; Alber Tom; Berger James M; Agard David A; Padmore Howard A
Suite of three protein crystallography beamlines with single superconducting bend magnet as the source.
Journal of synchrotron radiation 2004;11(Pt 6):447-55.
2004: Hanser B M; Gustafsson M G L; Agard D A; Sedat J W
Phase-retrieved pupil functions in wide-field fluorescence microscopy.
Journal of microscopy 2004;216(Pt 1):32-48.
2004: Zheng Qingxiong S; Braunfeld Michael B; Sedat John W; Agard David A
An improved strategy for automated electron microscopic tomography.
Journal of structural biology 2004;147(2):91-101.
2004: Harris Seth F; Shiau Andrew K; Agard David A
The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site.
Structure (London, England : 1993) 2004;12(6):1087-97.
2004: Fuhrmann Cynthia N; Kelch Brian A; Ota Nobuyuki; Agard David A
The 0.83 A resolution crystal structure of alpha-lytic protease reveals the detailed structure of the active site and identifies a source of conformational strain.
Journal of molecular biology 2004;338(5):999-1013.
2004: Cunningham Erin L; Agard David A
Disabling the folding catalyst is the last critical step in alpha-lytic protease folding.
Protein science : a publication of the Protein Society 2004;13(2):325-31.
2004: Truhlar Stephanie M E; Cunningham Erin L; Agard David A
The folding landscape of Streptomyces griseus protease B reveals the energetic costs and benefits associated with evolving kinetic stability.
Protein science : a publication of the Protein Society 2004;13(2):381-90.
2003: Cunningham Erin L; Agard David A
Interdependent folding of the N- and C-terminal domains defines the cooperative folding of alpha-lytic protease.
Biochemistry 2003;42(45):13212-9.
2003: Hanser Bridget M; Gustafsson Mats G L; Agard David A; Sedat John W
Phase retrieval for high-numerical-aperture optical systems.
Optics letters 2003;28(10):801-3.
2003: Kuntz Irwin D; Agard David A
Assessment of the role of computations in structural biology.
Advances in protein chemistry 2003;66():1-25.
2002: Chen Chih-Ying; Reese Michael L; Hwang Peter K; Ota Nobuyuki; Agard David; Brodsky Frances M
Clathrin light and heavy chain interface: alpha-helix binding superhelix loops via critical tryptophans.
The EMBO journal 2002;21(22):6072-82.
2002: Rice Luke M; Agard David A
Centriole duplication: centrin in on answers?
Current biology : CB 2002;12(18):R618-9.
2002: Cunningham Erin L; Mau Ted; Truhlar Stephanie M E; Agard David A
The pro region N-terminal domain provides specific interactions required for catalysis of alpha-lytic protease folding.
Biochemistry 2002;41(28):8860-7.
2002: Shiau Andrew K; Barstad Danielle; Radek James T; Meyers Marvin J; Nettles Kendall W; Katzenellenbogen Benita S; Katzenellenbogen John A; Agard David A; Greene Geoffrey L
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.
Nature structural biology 2002;9(5):359-64.
2002: Wille Holger; Michelitsch Melissa D; Guenebaut Vincent; Supattapone Surachai; Serban Ana; Cohen Fred E; Agard David A; Prusiner Stanley B
Structural studies of the scrapie prion protein by electron crystallography.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3563-8.
2002: Jaswal Sheila S; Sohl Julie L; Davis Jonathan H; Agard David A
Energetic landscape of alpha-lytic protease optimizes longevity through kinetic stability.
Nature 2002;415(6869):343-6.
2001: Ota N; Agard D A
Binding mode prediction for a flexible ligand in a flexible pocket using multi-conformation simulated annealing pseudo crystallographic refinement.
Journal of molecular biology 2001;314(3):607-17.
2001: Murphy S M; Preble A M; Patel U K; O'Connell K L; Dias D P; Moritz M; Agard D; Stults J T; Stearns T
GCP5 and GCP6: two new members of the human gamma-tubulin complex.
Molecular biology of the cell 2001;12(11):3340-52.
2001: Ota N; Agard D A
Enzyme specificity under dynamic control II: Principal component analysis of alpha-lytic protease using global and local solvent boundary conditions.
Protein science : a publication of the Protein Society 2001;10(7):1403-14.
2001: Marshall W F; Marko J F; Agard D A; Sedat J W
Chromosome elasticity and mitotic polar ejection force measured in living Drosophila embryos by four-dimensional microscopy-based motion analysis.
Current biology : CB 2001;11(8):569-78.
2001: Moritz M; Agard D A
Gamma-tubulin complexes and microtubule nucleation.
Current opinion in structural biology 2001;11(2):174-81.
2001: Kam Z; Hanser B; Gustafsson M G; Agard D A; Sedat J W
Computational adaptive optics for live three-dimensional biological imaging.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3790-5.
2001: Moritz M; Braunfeld M B; Alberts B M; Agard D A
Reconstitution of centrosome microtubule nucleation in Drosophila.
Methods in cell biology 2001;67():141-8.
2000: Moritz M; Braunfeld M B; Guénebaut V; Heuser J; Agard D A
Structure of the gamma-tubulin ring complex: a template for microtubule nucleation.
Nature cell biology 2000;2(6):365-70.
2000: Derman A I; Agard D A
Two energetically disparate folding pathways of alpha-lytic protease share a single transition state.
Nature structural biology 2000;7(5):394-7.
2000: Bass H W; Riera-Lizarazu O; Ananiev E V; Bordoli S J; Rines H W; Phillips R L; Sedat J W; Agard D A; Cande W Z
Evidence for the coincident initiation of homolog pairing and synapsis during the telomere-clustering (bouquet) stage of meiotic prophase.
Journal of cell science 2000;113 ( Pt 6)():1033-42.
2000: Jinnai H; Nishikawa Y; Spontak R J; Smith S D; Agard D A; Hashimoto T
Direct measurement of interfacial curvature distributions in a bicontinuous block copolymer morphology.
Physical review letters 2000;84(3):518-21.
2000: Kushner P J; Agard D; Feng W J; Lopez G; Schiau A; Uht R; Webb P; Greene G
Oestrogen receptor function at classical and alternative response elements.
Novartis Foundation symposium 2000;230():20-6; discussion 27-40.
1999: Cunningham E L; Jaswal S S; Sohl J L; Agard D A
Kinetic stability as a mechanism for protease longevity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11008-14.
1999: Gustafsson M G; Agard D A; Sedat J W
I5M: 3D widefield light microscopy with better than 100 nm axial resolution.
Journal of microscopy 1999;195(Pt 1):10-6.
1999: Anderson D E; Peters R J; Wilk B; Agard D A
alpha-lytic protease precursor: characterization of a structured folding intermediate.
Biochemistry 1999;38(15):4728-35.
1999: Miller D W; Agard D A
Enzyme specificity under dynamic control: a normal mode analysis of alpha-lytic protease.
Journal of molecular biology 1999;286(1):267-78.
1998: Shiau A K; Barstad D; Loria P M; Cheng L; Kushner P J; Agard D A; Greene G L
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.
Cell 1998;95(7):927-37.
1998: Sauter N K; Mau T; Rader S D; Agard D A
Structure of alpha-lytic protease complexed with its pro region.
Nature structural biology 1998;5(11):945-50.
1998: Sohl J L; Jaswal S S; Agard D A
Unfolded conformations of alpha-lytic protease are more stable than its native state.
Nature 1998;395(6704):817-9.
1998: Peters R J; Shiau A K; Sohl J L; Anderson D E; Tang G; Silen J L; Agard D A
Pro region C-terminus:protease active site interactions are critical in catalyzing the folding of alpha-lytic protease.
Biochemistry 1998;37(35):12058-67.
1998: Davis J H; Agard D A
Relationship between enzyme specificity and the backbone dynamics of free and inhibited alpha-lytic protease.
Biochemistry 1998;37(21):7696-707.
1998: Fung J C; Marshall W F; Dernburg A; Agard D A; Sedat J W
Homologous chromosome pairing in Drosophila melanogaster proceeds through multiple independent initiations.
The Journal of cell biology 1998;141(1):5-20.
1997: Han K F; Sedat J W; Agard D A
Practical image restoration of thick biological specimens using multiple focus levels in transmission electron microscopy.
Journal of structural biology 1997;120(3):237-44.
1997: Marshall W F; Straight A; Marko J F; Swedlow J; Dernburg A; Belmont A; Murray A W; Agard D A; Sedat J W
Interphase chromosomes undergo constrained diffusional motion in living cells.
Current biology : CB 1997;7(12):930-9.
1997: Davis J H; Agard D A; Handel T M; Basus V J
Alterations in chemical shifts and exchange broadening upon peptide boronic acid inhibitor binding to alpha-lytic protease.
Journal of biomolecular NMR 1997;10(1):21-7.
1997: Rader S D; Agard D A
Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution.
Protein science : a publication of the Protein Society 1997;6(7):1375-86.
1997: Bass H W; Marshall W F; Sedat J W; Agard D A; Cande W Z
Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase.
The Journal of cell biology 1997;137(1):5-18.
1997: Sohl J L; Shiau A K; Rader S D; Wilk B J; Agard D A
Inhibition of alpha-lytic protease by pro region C-terminal steric occlusion of the active site.
Biochemistry 1997;36(13):3894-902.
1996: Han K F; Gubbens A J; Sedat J W; Agard D A
Optimal strategies for imaging thick biological specimens: exit wavefront reconstruction and energy-filtered imaging.
Journal of microscopy 1996;183(Pt 2):124-32.
1996: Marshall W F; Dernburg A F; Harmon B; Agard D A; Sedat J W
Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster.
Molecular biology of the cell 1996;7(5):825-42.
1996: Dernburg A F; Broman K W; Fung J C; Marshall W F; Philips J; Agard D A; Sedat J W
Perturbation of nuclear architecture by long-distance chromosome interactions.
Cell 1996;85(5):745-59.
1996: Scalettar B A; Swedlow J R; Sedat J W; Agard D A
Dispersion, aberration and deconvolution in multi-wavelength fluorescence images.
Journal of microscopy 1996;182(Pt 1):50-60.
1996: Paddy M R; Saumweber H; Agard D A; Sedat J W
Time-resolved, in vivo studies of mitotic spindle formation and nuclear lamina breakdown in Drosophila early embryos.
Journal of cell science 1996;109 ( Pt 3)():591-607.
1996: Fung J C; Liu W; de Ruijter W J; Chen H; Abbey C K; Sedat J W; Agard D A
Toward fully automated high-resolution electron tomography.
Journal of structural biology 1996;116(1):181-9.
1996: Chen H; Hughes D D; Chan T A; Sedat J W; Agard D A
IVE (Image Visualization Environment): a software platform for all three-dimensional microscopy applications.
Journal of structural biology 1996;116(1):56-60.
1995: Moritz M; Braunfeld M B; Sedat J W; Alberts B; Agard D A
Microtubule nucleation by gamma-tubulin-containing rings in the centrosome.
Nature 1995;378(6557):638-40.
1995: Mace J E; Agard D A
Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity.
Journal of molecular biology 1995;254(4):720-36.
1995: Urata Y; Parmelee S J; Agard D A; Sedat J W
A three-dimensional structural dissection of Drosophila polytene chromosomes.
The Journal of cell biology 1995;131(2):279-95.
1995: Moritz M; Braunfeld M B; Fung J C; Sedat J W; Alberts B M; Agard D A
Three-dimensional structural characterization of centrosomes from early Drosophila embryos.
The Journal of cell biology 1995;130(5):1149-59.
1995: Mace J E; Wilk B J; Agard D A
Functional linkage between the active site of alpha-lytic protease and distant regions of structure: scanning alanine mutagenesis of a surface loop affects activity and substrate specificity.
Journal of molecular biology 1995;251(1):116-34.
1995: Han K F; Sedat J W; Agard D A
Mechanism of image formation for thick biological specimens: exit wavefront reconstruction and electron energy-loss spectroscopic imaging.
Journal of microscopy 1995;178(Pt 2):107-19.
1994: Dong L M; Wilson C; Wardell M R; Simmons T; Mahley R W; Weisgraber K H; Agard D A
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.
The Journal of biological chemistry 1994;269(35):22358-65.
1994: Wilson C; Mau T; Weisgraber K H; Wardell M R; Mahley R W; Agard D A
Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.
Structure (London, England : 1993) 1994;2(8):713-8.
1994: Braunfeld M B; Koster A J; Sedat J W; Agard D A
Cryo automated electron tomography: towards high-resolution reconstructions of plastic-embedded structures.
Journal of microscopy 1994;174(Pt 2):75-84.
1994: Dawe R K; Sedat J W; Agard D A; Cande W Z
Meiotic chromosome pairing in maize is associated with a novel chromatin organization.
Cell 1994;76(5):901-12.
1993: Baker D; Shiau A K; Agard D A
The role of pro regions in protein folding.
Current opinion in cell biology 1993;5(6):966-70.
1993: Swedlow J R; Agard D A; Sedat J W
Chromosome structure inside the nucleus.
Current opinion in cell biology 1993;5(3):412-6.
1993: Agard D A
To fold or not to fold....
Science (New York, N.Y.) 1993;260(5116):1903-4.
1993: Swedlow J R; Sedat J W; Agard D A
Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy.
Cell 1993;73(1):97-108.
1993: Wilson C; Gregoret L M; Agard D A
Modeling side-chain conformation for homologous proteins using an energy-based rotamer search.
Journal of molecular biology 1993;229(4):996-1006.
1993: Hiraoka Y; Dernburg A F; Parmelee S J; Rykowski M C; Agard D A; Sedat J W
The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis.
The Journal of cell biology 1993;120(3):591-600.
1992: Koster A J; Chen H; Sedat J W; Agard D A
Automated microscopy for electron tomography.
Ultramicroscopy 1992;46(1-4):207-27.
1992: Paddy M R; Agard D A; Sedat J W
An extended view of nuclear lamin structure, function, and dynamics.
Seminars in cell biology 1992;3(4):255-66.
1992: Fujishige A; Smith K R; Silen J L; Agard D A
Correct folding of alpha-lytic protease is required for its extracellular secretion from Escherichia coli.
The Journal of cell biology 1992;118(1):33-42.
1992: Baker D; Silen J L; Agard D A
Protease pro region required for folding is a potent inhibitor of the mature enzyme.
Proteins 1992;12(4):339-44.
1992: Baker D; Sohl J L; Agard D A
A protein-folding reaction under kinetic control.
Nature 1992;356(6366):263-5.
1991: Bone R; Fujishige A; Kettner C A; Agard D A
Structural basis for broad specificity in alpha-lytic protease mutants.
Biochemistry 1991;30(43):10388-98.
1991: Wilson C; Mace J E; Agard D A
Computational method for the design of enzymes with altered substrate specificity.
Journal of molecular biology 1991;220(2):495-506.
1991: Wilson C; Wardell M R; Weisgraber K H; Mahley R W; Agard D A
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.
Science (New York, N.Y.) 1991;252(5014):1817-22.
1991: Kam Z; Minden J S; Agard D A; Sedat J W; Leptin M
Drosophila gastrulation: analysis of cell shape changes in living embryos by three-dimensional fluorescence microscopy.
Development (Cambridge, England) 1991;112(2):365-70.
1991: Hiraoka Y; Swedlow J R; Paddy M R; Agard D A; Sedat J W
Three-dimensional multiple-wavelength fluorescence microscopy for the structural analysis of biological phenomena.
Seminars in cell biology 1991;2(3):153-65.
1991: Bone R; Sampson N S; Bartlett P A; Agard D A
Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters.
Biochemistry 1991;30(8):2263-72.
1991: Caldwell J W; Agard D A; Kollman P A
Free energy calculations on binding and catalysis by alpha-lytic protease: the role of substrate size in the P1 pocket.
Proteins 1991;10(2):140-8.
1990: Hiraoka Y; Agard D A; Sedat J W
Temporal and spatial coordination of chromosome movement, spindle formation, and nuclear envelope breakdown during prometaphase in Drosophila melanogaster embryos.
The Journal of cell biology 1990;111(6 Pt 2):2815-28.
1990: Paddy M R; Belmont A S; Saumweber H; Agard D A; Sedat J W
Interphase nuclear envelope lamins form a discontinuous network that interacts with only a fraction of the chromatin in the nuclear periphery.
Cell 1990;62(1):89-106.
1989: Hiraoka Y; Minden J S; Swedlow J R; Sedat J W; Agard D A
Focal points for chromosome condensation and decondensation revealed by three-dimensional in vivo time-lapse microscopy.
Nature 1989;342(6247):293-6.
1989: Silen J L; Agard D A
The alpha-lytic protease pro-region does not require a physical linkage to activate the protease domain in vivo.
Nature 1989;341(6241):462-4.
1989: Bone R; Frank D; Kettner C A; Agard D A
Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates.
Biochemistry 1989;28(19):7600-9.
1989: Minden J S; Agard D A; Sedat J W; Alberts B M
Direct cell lineage analysis in Drosophila melanogaster by time-lapse, three-dimensional optical microscopy of living embryos.
The Journal of cell biology 1989;109(2):505-16.
1989: Belmont A S; Braunfeld M B; Sedat J W; Agard D A
Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro.
Chromosoma 1989;98(2):129-43.
1989: Bone R; Silen J L; Agard D A
Structural plasticity broadens the specificity of an engineered protease.
Nature 1989;339(6221):191-5.
1989: Silen J L; Frank D; Fujishige A; Bone R; Agard D A
Analysis of prepro-alpha-lytic protease expression in Escherichia coli reveals that the pro region is required for activity.
Journal of bacteriology 1989;171(3):1320-5.
1988: Kettner C A; Bone R; Agard D A; Bachovchin W W
Kinetic properties of the binding of alpha-lytic protease to peptide boronic acids.
Biochemistry 1988;27(20):7682-8.
1988: Silen J L; McGrath C N; Smith K R; Agard D A
Molecular analysis of the gene encoding alpha-lytic protease: evidence for a preproenzyme.
Gene 1988;69(2):237-44.
1988: Rykowski M C; Parmelee S J; Agard D A; Sedat J W
Precise determination of the molecular limits of a polytene chromosome band: regulatory sequences for the Notch gene are in the interband.
Cell 1988;54(4):461-72.
1987: Bone R; Shenvi A B; Kettner C A; Agard D A
Serine protease mechanism: structure of an inhibitory complex of alpha-lytic protease and a tightly bound peptide boronic acid.
Biochemistry 1987;26(24):7609-14.
1987: Hiraoka Y; Sedat J W; Agard D A
The use of a charge-coupled device for quantitative optical microscopy of biological structures.
Science (New York, N.Y.) 1987;238(4823):36-41.
1987: Belmont A S; Sedat J W; Agard D A
A three-dimensional approach to mitotic chromosome structure: evidence for a complex hierarchical organization.
The Journal of cell biology 1987;105(1):77-92.

Sign-in to see more