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Keiichi Nakayama

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Shohei Furutachi; Akinobu Matsumoto; Keiichi I Nakayama; Yukiko Gotoh
p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis.
Linsey Reavie; Shoichiro Takeishi; Omar Abdel-Wahab; Beatriz Aranda-Orgilles; Shannon M Buckley; Sherif Ibrahim; Evangelia Loizou; Keiichi I Nakayama; Delphine Ndiaye-Lobry; Ioannis Aifantis
Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.
Shoichiro Takeishi; Ichiro Onoyama; Atsushi Hirao; Akinobu Matsumoto; Kazuhito Naka; Keiichi I Nakayama
Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.

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All Publications

2013: Shohei Furutachi; Akinobu Matsumoto; Keiichi I Nakayama; Yukiko Gotoh
p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis.
The EMBO journal 2013;32(7):970-81.
2013: Linsey Reavie; Shoichiro Takeishi; Omar Abdel-Wahab; Beatriz Aranda-Orgilles; Shannon M Buckley; Sherif Ibrahim; Evangelia Loizou; Keiichi I Nakayama; Delphine Ndiaye-Lobry; Ioannis Aifantis
Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.
Cancer cell 2013;23(3):362-75.
2013: Shoichiro Takeishi; Ichiro Onoyama; Atsushi Hirao; Akinobu Matsumoto; Kazuhito Naka; Keiichi I Nakayama
Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.
Cancer cell 2013;23(3):347-61.
2013: Arisa Hirano; Hiroko Kozuka-Hata; Darin Lanjakornsiripan; Masaki Matsumoto; Tomoki Nakagawa; Keiichi I Nakayama; Masaaki Oyama; Ryosuke Tsunematsu; Kanae Yumimoto; Yoshitaka Fukada
FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes.
Cell 2013;152(5):1106-18.
2013: Akinobu Matsumoto; Keiichi I Nakayama
Role of key regulators of the cell cycle in maintenance of hematopoietic stem cells.
Biochimica et biophysica acta 2013;1830(2):2335-44.
2013: Shotaro Saita; Michiko Shirane; Keiichi I Nakayama
Selective escape of proteins from the mitochondria during mitophagy.
Nature communications 2013;4():1410.
2012: Keiichi I Nakayama; Takehito Sato; Kouji Segawa; S Souma; Tatsuya Takahashi; Y Tanaka; K Eto; Yoichi Ando
Manipulation of topological states and the bulk band gap using natural heterostructures of a topological insulator.
Physical review letters 2012;109(23):236804.
2012: Yasutaka Okita; Keiichi I Nakayama
UPS delivers pluripotency.
Cell stem cell 2012;11(6):728-30.
2012: Viviana Cremasco; Corinne E Decker; Perry J Blackshear; Daniel B Graham; Traian S Lupu; Keiko Nakayama; Keiichi I Nakayama; Deborah V Novack; Deborah Stumpo; Roberta Faccio
Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(12):2452-63.
2012: R Ang; E Ieki; L J Li; W J Lu; Keiichi I Nakayama; Takehito Sato; Y P Sun; Y Tanaka; Tatsuya Takahashi
Real-space coexistence of the melted Mott state and superconductivity in Fe-substituted 1T-TaS2.
Physical review letters 2012;109(17):176403.
2012: Yuki Tateishi; Eiji Hara; Tomoharu Kanie; Akinobu Matsumoto; Keiko Nakayama; Keiichi I Nakayama
Development of mice without Cip/Kip CDK inhibitors.
Biochemical and biophysical research communications 2012;427(2):285-92.
2012: Yasutaka Okita; Kanae Yumimoto; Rieko Isoshita; Akinobu Matsumoto; Keiichi I Nakayama
Increased efficiency in the generation of induced pluripotent stem cells by Fbxw7 ablation.
Genes to cells : devoted to molecular & cellular mechanisms 2012;17(9):768-77.
2012: Hiroko Hoshi; Ryotaro Iwasaki; Hiroya Kanagawa; Eri Katsuyama; Toshihiro Kawamoto; Kyoko Kitagawa; Tami Kobayashi; Morio Matsumoto; Hiroya Miyamoto; Kana Miyamoto; Yoshiteru Miyauchi; Tomoaki Mori; Hideo Morioka; Keiichi I Nakayama; Ikuroh Ohsawa; Shigeo Ohta; Motoaki Sano; Yuiko Sato; Yoshiaki Toyama; Shigeyuki Yoshida; Kazuhiro Chiba; Atsuhiro Fujie; Yoshinari Fujita; Keiichi Fukuda; Atsushi Funayama; Wu Hao; Kazuaki Hashimoto; Takeshi Miyamoto
Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(9):2015-23.
2012: Yasuyuki Kita; Masaaki Nishiyama; Keiichi I Nakayama
Identification of CHD7S as a novel splicing variant of CHD7 with functions similar and antagonistic to those of the full-length CHD7L.
Genes to cells : devoted to molecular & cellular mechanisms 2012;17(7):536-47.
2012: Takehiko Yokobori; Hideshi Ishii; Masaaki Iwatsuki; Takeshi Iwaya; Hiroyuki Kuwano; Koshi Mimori; Keiichi I Nakayama; Ichiro Onoyama; Tetsuya Sato; Tomoya Sudo; Fumiaki Tanaka; Yoichi Tanaka; Hiroyuki Toh; Masaki Mori
Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma.
International journal of oncology 2012;41(1):253-9.
2012: Kiyotaka Oshikawa; Masaki Matsumoto; Keiichi I Nakayama
[Comprehensive study of protein ubiquitylation sites by conjugation of engineered lysine-less ubiquitin].
Seikagaku. The Journal of Japanese Biochemical Society 2012;84(6):479-87.
2012: Jonathan E Grim; Katherine A Guthrie; Amanda Hagar; Jessica Hespelt; Sue E Knoblaugh; Keiichi I Nakayama; Tom Small; Jherek Swanger; Jeffrey Delrow; William M Grady; Bruce E Clurman
Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.
Molecular and cellular biology 2012;32(11):2160-7.
2012: Hidefumi Fukushima; Daming Gao; Steven P Gygi; Hiroyuki Inuzuka; Eijiro Jimi; Alan W Lau; Akinobu Matsumoto; Keiko Nakayama; Keiichi I Nakayama; Shavali Shaik; Lixin Wan; Min Yuan; Bo Zhai; John M Asara; Wenyi Wei
SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.
Cell reports 2012;1(5):434-43.
2012: Chia-Hsin Chan; Zizhen Feng; Leo G Flores; Yuan Gao; John D Hazle; Hsuan-Ying Huang; Mien-Chie Hung; Szu-Wei Lee; Chien-Feng Li; Keiichi I Nakayama; Dos Sarbassov; Yiping Shao; Kelvin K C Tsai; Wenyi Wei; Wei-Lei Yang; Dihua Yu; Hui-Kuan Lin
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis.
Cell 2012;149(5):1098-111.
2012: Ning Liu; Masaki Matsumoto; Makoto Nakanishi; Keiichi I Nakayama; Hiroyuki Niida; Senji Shirasawa; Sayuri Suzuki; Kyoko Kitagawa; Yojiro Kotake; Masatoshi Kitagawa
Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling.
The EMBO journal 2012;31(10):2365-77.
2012: S Souma; Tatsuya Takahashi; K Eto; Keiichi I Nakayama; M Nomura; Takehito Sato; Kouji Segawa; Yoichi Ando
Topological surface states in lead-based ternary telluride Pb(Bi(1-x)Sb(x))2Te4.
Physical review letters 2012;108(11):116801.
2012: Kiyotaka Oshikawa; Koji Oyamada; Masaki Matsumoto; Keiichi I Nakayama
Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
Journal of proteome research 2012;11(2):796-807.
2012: Tomoharu Kanie; Akinobu Matsumoto; Masaki Matsumoto; Hirokazu Nakatsumi; Ichiro Onoyama; Yuki Tateishi; Ryosuke Tsunematsu; Masanori Yamada; So Yamamura; Keiichi I Nakayama
Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation.
Molecular and cellular biology 2012;32(3):590-605.
2012: K Umezawa; D-M Wang; G F Chen; Hong Ding; J B He; Y Li; Z-H Liu; H Miao; Keiichi I Nakayama; P Richard; Takehito Sato; Tatsuya Takahashi; S-C Wang
Unconventional anisotropic s-wave superconducting gaps of the LiFeAs iron-pnictide superconductor.
Physical review letters 2012;108(3):037002.
2012: Sayuri Suzuki; Akashi Togawa; Tatsuo Yamamoto; Hirotaka Fukasawa; Kyoko Kitagawa; Yojiro Kotake; Ning Liu; Taro Misaki; Keiko Nakayama; Keiichi I Nakayama; Hiroyuki Niida; Naro Ohashi; Masatoshi Kitagawa
The amelioration of renal damage in Skp2-deficient mice canceled by p27 Kip1 deficiency in Skp2-/- p27-/- mice.
PloS one 2012;7(4):e36249.
2011: Fumiko Matsuzaki; Masaki Matsumoto; Michiko Shirane; Keiichi I Nakayama
Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.
Molecular biology of the cell 2011;22(23):4602-20.
2011: Jose J Fuster; Herminia González-Navarro; José Martínez-González; Pedro Molina-Sànchez; Keiko Nakayama; Keiichi I Nakayama; Cristina Rodríguez; Angela Vinué; Maria J Andrés-Manzano; Antonio Bernad; Antonio Díez-Juan; Vicente Andrés
Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(11):2455-63.
2011: Akinobu Matsumoto; Keiko Nakayama; Ichiro Onoyama; Etsuo Susaki; Mikio Hoshino; Keiichi I Nakayama
Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice.
Molecular and cellular biology 2011;31(20):4176-92.
2011: Fumihiko Okumura; Masaki Matsumoto; Keiichi I Nakayama; Akiko J Okumura; Shigetsugu Hatakeyama
TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells.
Biochimica et biophysica acta 2011;1813(10):1784-92.
2011: Toshiro Moroishi; Masaaki Nishiyama; Yukiko Takeda; Kazuhiro Iwai; Keiichi I Nakayama
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Cell metabolism 2011;14(3):339-51.
2011: Akinobu Matsumoto; Keiko Nakayama; Tomoharu Kanie; Ichiro Onoyama; Etsuo Susaki; Shoichiro Takeishi; Yuki Tateishi; Keiichi I Nakayama
p57 is required for quiescence and maintenance of adult hematopoietic stem cells.
Cell stem cell 2011;9(3):262-71.
2011: Peng Zou; Ikue Tai; Fujiko Tsukahara; Hiroki Yoshihara; Kentaro Hosokawa; Yoshiro Maru; Keiko Nakayama; Keiichi I Nakayama; Kaori Shinmyozu; Toshio Suda
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70.
Cell stem cell 2011;9(3):247-61.
2011: Zhiqian Yu; William E Bunney; Helen B Kim; Hiroshi Komatsu; Hiroo Matsuoka; Keiichi I Nakayama; Chiaki Ono; Nobutaka Sakae; Ichiro Sora; Yoichiro Tanabe; Hiroaki Tomita
Four mood stabilizers commonly induce FEZ1 expression in human astrocytes.
Bipolar disorders 2011;13(5-6):486-99.
2011: Abbas Fotovati; Keiko Nakayama; Samah Abu-Ali; Keiichi I Nakayama
Impaired ovarian development and reduced fertility in female mice deficient in Skp2.
Journal of anatomy 2011;218(6):668-77.
2011: Shin-ichiro Inoue; Tomonao Matsushita; Yuta Tomokiyo; Masaki Matsumoto; Keiichi I Nakayama; Toshinori Kinoshita; Ken-ichiro Shimazaki
Functional analyses of the activation loop of phototropin2 in Arabidopsis.
Plant physiology 2011;156(1):117-28.
2011: Changming Lu; Xin Huang; Xiaoxiao Zhang; Kristin Roensch; Qing Cao; Keiichi I Nakayama; Bruce R Blazar; Yan Zeng; Xianzheng Zhou
miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1.
Blood 2011;117(16):4293-303.
2011: Akinobu Matsumoto; Ichiro Onoyama; Takehiko Sunabori; Ryoichiro Kageyama; Hideyuki Okano; Keiichi I Nakayama
Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells.
The Journal of biological chemistry 2011;286(15):13754-64.
2011: Ryo Tachiyama; Daisuke Ishikawa; Masaki Matsumoto; Keiichi I Nakayama; Tamotsu Yoshimori; Sadaki Yokota; Masaru Himeno; Yoshitaka Tanaka; Hideaki Fujita
Proteome of ubiquitin/MVB pathway: possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation.
Genes to cells : devoted to molecular & cellular mechanisms 2011;16(4):448-66.
2011: Akinobu Matsumoto; Yuki Tateishi; Ichiro Onoyama; Yasutaka Okita; Keiko Nakayama; Keiichi I Nakayama
Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress.
Cancer science 2011;102(4):749-55.
2011: Hiroyuki Inuzuka; Shavali Shaik; Ichiro Onoyama; Daming Gao; Alan Tseng; richard s maser; Bo Zhai; Lixin Wan; Alejandro Gutierrez; Alan W Lau; Yonghong Xiao; Amanda L Christie; Jon Aster; Jeffrey Settleman; Steven P Gygi; Andrew L Kung; Thomas Look; Keiichi I Nakayama; Ronald A DePinho; Wenyi Wei
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Nature 2011;471(7336):104-9.
2011: Hong Wu; Scott L Pomeroy; Manuel Ferreira; Natalia Teider; Juliana Mariani; Keiichi I Nakayama; Shigetsugu Hatakeyama; Victor A Tron; Linda F Saltibus; Leo Spyracopoulos; Roger P Leng
UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53.
Nature medicine 2011;17(3):347-55.
2011: Hirono Iriuchishima; Keiyo Takubo; Sahoko Matsuoka; Ichiro Onoyama; Keiichi I Nakayama; Yoshihisa Nojima; Toshio Suda
Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression.
Blood 2011;117(8):2373-7.
2011: Koko Katagiri; Yoshihiro Ueda; Takashi Tomiyama; Kaneki Yasuda; Yoshinobu Toda; Susumu Ikehara; Keiichi I Nakayama; Tatsuo Kinashi
Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1.
Immunity 2011;34(1):24-38.
2011: Ichiro Onoyama; Atsushi Suzuki; Akinobu Matsumoto; Kengo Tomita; Hideki Katagiri; Yuichi Oike; Keiko Nakayama; Keiichi I Nakayama
Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.
The Journal of clinical investigation 2011;121(1):342-54.
2011: Miyuki Bohgaki; Masaki Matsumoto; Tatsuya Atsumi; Takeshi Kondo; Shinsuke Yasuda; Tetsuya Horita; Keiichi I Nakayama; Fumihiko Okumura; Shigetsugu Hatakeyama; Takao Koike
Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin.
Journal of cellular and molecular medicine 2011;15(1):141-51.
2010: Hiroshi Hayakawa; Aya Fujikane; Riyoko Ito; Masaki Matsumoto; Keiichi I Nakayama; Mutsuo Sekiguchi
Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress.
Biochemical and biophysical research communications 2010;403(2):220-4.
2010: Keiichi I Nakayama; Takehito Sato; P Richard; T Kawahara; Y Sekiba; T Qian; G F Chen; J L Luo; N L Wang; Hong Ding; Tatsuya Takahashi
Angle-resolved photoemission spectroscopy of the iron-chalcogenide superconductor Fe1.03Te0.7Se0.3: strong coupling behavior and the universality of interband scattering.
Physical review letters 2010;105(19):197001.
2010: Hiroyuki Takeda; Yoshifumi Kawamura; Aya Miura; Masatoshi Mori; Ai Wakamatsu; Jun-ichi Yamamoto; Takao Isogai; Masaki Matsumoto; Keiichi I Nakayama; Tohru Natsume; Nobuo Nomura; Naoki Goshima
Comparative analysis of human SRC-family kinase substrate specificity in vitro.
Journal of proteome research 2010;9(11):5982-93.
2010: Yu-ichi Tsukada; Keiichi I Nakayama
In vitro histone demethylase assay.
Cold Spring Harbor protocols 2010;2010(10):pdb.prot5512.
2010: Robert C Benirschke; James R Thompson; Yves Nominé; Emeric Wasielewski; Nenad Juranić; Slobodan Macura; Shigetsugu Hatakeyama; Keiichi I Nakayama; Maria-Victoria Botuyan; Georges Mer
Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4.
Structure (London, England : 1993) 2010;18(8):955-65.
2010: Heng Ma; Lu Yu; Emily A Byra; Nan Hu; Kyoko Kitagawa; Keiichi I Nakayama; Toshihiro Kawamoto; Jun Ren
Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases.
Journal of molecular and cellular cardiology 2010;49(2):322-9.
2010: Etsuo Susaki; Keiichi I Nakayama
An animal model manifesting neurodegeneration and obesity.
Aging 2010;2(7):453-6.
2010: Fumihiko Okumura; Yui Matsunaga; Yuta Katayama; Keiichi I Nakayama; Shigetsugu Hatakeyama
TRIM8 modulates STAT3 activity through negative regulation of PIAS3.
Journal of cell science 2010;123(Pt 13):2238-45.
2010: Akiko Mizokami; Hiroto Tanaka; Hitoshi Ishibashi; Hisanori Umebayashi; Kiyoko Fukami; Tadaomi Takenawa; Keiichi I Nakayama; Takeshi Yokoyama; Junichi Nabekura; Takashi Kanematsu; Masato Hirata
GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice.
Journal of neurochemistry 2010;114(1):302-10.
2010: Atsushi Hatano; Masaki Matsumoto; Toru Higashinakagawa; Keiichi I Nakayama
Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3.
Biochemical and biophysical research communications 2010;397(1):93-9.
2010: Etsuo Susaki; Chie Kaneko-Oshikawa; Keishi Miyata; Mitsuhisa Tabata; Tetsuya Yamada; Yuichi Oike; Hideki Katagiri; Keiichi I Nakayama
Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity.
The Journal of biological chemistry 2010;285(20):15538-47.
2010: Chia-Hsin Chan; Szu-Wei Lee; Chien-Feng Li; Jing Wang; Wei-Lei Yang; Ching-Yuan Wu; Juan Wu; Keiichi I Nakayama; Hong-Yo Kang; Hsuan-Ying Huang; Mien-Chie Hung; Pier Paolo Pandolfi; Hui-Kuan Lin
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.
Nature cell biology 2010;12(5):457-67.
2010: Masaaki Iwatsuki; Koshi Mimori; Hideshi Ishii; Takehiko Yokobori; Yasushi Takatsuno; Tetsuya Sato; Hiroyuki Toh; Ichiro Onoyama; Keiichi I Nakayama; Hideo Baba; Masaki Mori
Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: clinical significance.
International journal of cancer. Journal international du cancer 2010;126(8):1828-37.
2010: P Richard; Keiichi I Nakayama; Takehito Sato; M Neupane; Y-M Xu; J H Bowen; G F Chen; J L Luo; N L Wang; X Dai; Z Fang; Hong Ding; Tatsuya Takahashi
Observation of Dirac cone electronic dispersion in BaFe2As2.
Physical review letters 2010;104(13):137001.
2010: Hui-Kuan Lin; Zhenbang Chen; Guocan Wang; Caterina Nardella; Szu-Wei Lee; Chia-Hsin Chan; Chan-Hsin Chan; Wei-Lei Yang; Jing Wang; Ainara Egia; Keiichi I Nakayama; Carlos Cordon-Cardo; Julie T Feldstein; Pier Paolo Pandolfi
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.
Nature 2010;464(7287):374-9.
2010: Jennifer B Old; Susanne Kratzat; Alexander Hoellein; Steffi Graf; Jonas A Nilsson; Lisa Nilsson; Keiichi I Nakayama; Christian Peschel; John L Cleveland; Ulrich B Keller
Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis.
Molecular cancer research : MCR 2010;8(3):353-62.
2010: Yu-ichi Tsukada; Tohru Ishitani; Keiichi I Nakayama
KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development.
Genes & development 2010;24(5):432-7.
2010: Makoto Fujii; Takashi Kanematsu; Hitoshi Ishibashi; Kiyoko Fukami; Tadaomi Takenawa; Keiichi I Nakayama; Stephen J Moss; Junichi Nabekura; Masato Hirata
Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors.
The Journal of biological chemistry 2010;285(7):4837-46.
2010: Hirobumi Tada; Hirotaka James Okano; Hiroshi Takagi; Shinsuke Shibata; Ikuko Yao; Masaki Matsumoto; Toru Saiga; Keiichi I Nakayama; Haruo Kashima; Takuya Takahashi; Mitsutoshi Setou; Hideyuki Okano
Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.
The Journal of biological chemistry 2010;285(6):3840-9.
2010: Chiho Ohzono; Sachise Etoh; Masaki Matsumoto; Keiichi I Nakayama; Yuko Hirota; Yoshitaka Tanaka; Hideaki Fujita
Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43.
Biological & pharmaceutical bulletin 2010;33(6):951-7.
2010: Sakae Tanaka; Hidetoshi Wakeyama; Toru Akiyama; Katsuhiko Takahashi; Hitoshi Amano; Keiichi I Nakayama; Kozo Nakamura
Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and Caspase-3.
Advances in experimental medicine and biology 2010;658():111-6.
2009: Akiko Oyamada; Hiori Ikebe; Momoe Itsumi; Hirokazu Saiwai; Seiji Okada; Kazuya Shimoda; Yoichiro Iwakura; Keiichi I Nakayama; Yukihide Iwamoto; Yasunobu Yoshikai; Hisakata Yamada
Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):7539-46.
2009: Isidora Ranchal; Raúl González; Rosario I Bello; Gustavo Ferrín; Ana B Hidalgo; Clara I Linares; Patricia Aguilar-Melero; Sandra González-Rubio; Pilar Barrera; Trinidad Marchal; Keiichi I Nakayama; Manuel De la Mata; Jordi Muntané
The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity.
International journal of cancer. Journal international du cancer 2009;125(10):2270-80.
2009: Yih-Jer Wu; Graciela B Sala-Newby; Kuo-Tung Shu; Hung-I Yeh; Keiichi I Nakayama; Keiko Nakayama; Andrew C Newby; Mark Bond
S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo.
Journal of vascular surgery 2009;50(5):1135-42.
2009: Miho Matsuda; Koushirou Tsutsumi; Takashi Kanematsu; Kiyoko Fukami; Yoshihiro Terada; Tadaomi Takenawa; Keiichi I Nakayama; Masato Hirata
Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels.
Biology of reproduction 2009;81(4):681-9.
2009: Xiaogang Jiang; Paul F Austin; Robert A Niederhoff; Scott R Manson; Jacob J Riehm; Brian L Cook; G Pengue; Kanchan Chitaley; Keiko Nakayama; Keiichi I Nakayama; Steven J Weintraub
Mechanoregulation of proliferation.
Molecular and cellular biology 2009;29(18):5104-14.
2009: Etsuo Susaki; Keiichi I Nakayama
Functional similarities and uniqueness of p27 and p57: insight from a knock-in mouse model.
Cell cycle (Georgetown, Tex.) 2009;8(16):2497-501.
2009: Takehito Sato; Keiichi I Nakayama; Y Sekiba; P Richard; Y-M Xu; S Souma; Tatsuya Takahashi; G F Chen; J L Luo; N L Wang; Hong Ding
Band structure and fermi surface of an extremely overdoped iron-based superconductor KFe2As2.
Physical review letters 2009;103(4):047002.
2009: Masaki Matsumoto; Koji Oyamada; Hidehisa Takahashi; Takamichi Sato; Shigetsugu Hatakeyama; Keiichi I Nakayama
Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways.
Proteomics 2009;9(13):3549-63.
2009: Toru Saiga; Takaichi Fukuda; Masaki Matsumoto; Hirobumi Tada; Hirotaka James Okano; Hideyuki Okano; Keiichi I Nakayama
Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.
Molecular and cellular biology 2009;29(13):3529-43.
2009: Keiichi I Nakayama; Takehito Sato; Y Sekiba; K Terashima; P Richard; Tatsuya Takahashi; K Kudo; N Okumura; T Sasaki; N Kobayashi
Evolution of a pairing-induced pseudogap from the superconducting gap of (Bi,Pb)2Sr2CuO6.
Physical review letters 2009;102(22):227006.
2009: Taichi Kimura; Mieko Sakai; Kouichi Tabu; Lei Wang; Ryosuke Tsunematsu; Masumi Tsuda; Hirofumi Sawa; Kazuo Nagashima; Hiroshi Nishihara; Shigetsugu Hatakeyama; Keiko Nakayama; Marc Ladanyi; Shinya Tanaka; Keiichi I Nakayama
Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration.
Laboratory investigation; a journal of technical methods and pathology 2009;89(6):645-56.
2009: Shotaro Saita; Michiko Shirane; Tohru Natume; Shun-ichiro Iemura; Keiichi I Nakayama
Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein.
The Journal of biological chemistry 2009;284(20):13766-77.
2009: Takehiko Yokobori; Koshi Mimori; Masaaki Iwatsuki; Hideshi Ishii; Ichiro Onoyama; Takeo Fukagawa; Hiroyuki Kuwano; Keiichi I Nakayama; Masaki Mori
p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases.
Cancer research 2009;69(9):3788-94.
2009: Takayuki Tsukuba; Michiyo Yanagawa; Kuniaki Okamoto; Yoshiko Okamoto; Yoshiyuki Yasuda; Keiichi I Nakayama; Tomoko Kadowaki; Kenji Yamamoto
Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages.
Journal of biochemistry 2009;145(5):565-73.
2009: Partha Mitra; Prachi N Ghule; Margaretha van der Deen; Ricardo Medina; Rong-Lin Xie; William F Holmes; Xin Ye; Keiichi I Nakayama; J Wade Harper; Janet L Stein; Gary S Stein; Andre J van Wijnen
CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P.
Journal of cellular physiology 2009;219(2):438-48.
2009: Hui-Kuan Lin; Guocan Wang; Zhenbang Chen; Julie T Feldstein; Yan Liu; Chia-Hsin Chan; Wei-Lei Yang; Hediye Erdjument-Bromage; Keiichi I Nakayama; Stephen D Nimer; Paul Tempst; Pier Paolo Pandolfi
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.
Nature cell biology 2009;11(4):420-32.
2009: Etsuo Susaki; Keiko Nakayama; Lili Yamasaki; Keiichi I Nakayama
Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5192-7.
2009: Akinori Endo; Masaki Matsumoto; Toshifumi Inada; Akitsugu Yamamoto; Keiichi I Nakayama; Naomi Kitamura; Masayuki Komada
Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.
Journal of cell science 2009;122(Pt 5):678-86.
2009: Mohd Minhajuddin; Kaiser M Bijli; Fabeha Fazal; Antonella Sassano; Keiichi I Nakayama; Nissim Hay; Leonidas C Platanias; Arshad Rahman
Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells.
The Journal of biological chemistry 2009;284(7):4052-61.
2009: Masaaki Nishiyama; Kiyotaka Oshikawa; Yu-ichi Tsukada; Tadashi Nakagawa; Shun-ichiro Iemura; Tohru Natsume; Yuhong Fan; Akira Kikuchi; Arthur I Skoultchi; Keiichi I Nakayama
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.
Nature cell biology 2009;11(2):172-82.
2009: Y Akasaki; Shuichi Matsuda; Keiichi I Nakayama; Shuji Fukagawa; Hiromasa Miura; Yukihide Iwamoto
Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(2):235-43.
2009: P Richard; Takehito Sato; Keiichi I Nakayama; S Souma; Tatsuya Takahashi; Y-M Xu; G F Chen; J L Luo; N L Wang; Hong Ding
Angle-resolved photoemission spectroscopy of the Fe-Based Ba0.6K0.4Fe2As2 high temperature superconductor: evidence for an orbital selective electron-mode coupling.
Physical review letters 2009;102(4):047003.
2009: Yu Lu; Olasunkanmi A J Adegoke; Alain Nepveu; Keiichi I Nakayama; Nathalie Bedard; Dongmei Cheng; Junmin Peng; Simon S Wing
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1.
Molecular and cellular biology 2009;29(2):547-58.
2008: Gustavo A Miranda-Carboni; Susan A Krum; Kathleen Yee; Miguel Nava; Qiming E Deng; Shehla Pervin; Alicia Collado-Hidalgo; Zoran Galic; Jerome A Zack; Keiko Nakayama; Keiichi I Nakayama; Timothy F Lane
A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.
Genes & development 2008;22(22):3121-34.
2008: Chie Kanei-Ishii; Teruaki Nomura; Tsuyoshi Takagi; Nobumoto Watanabe; Keiichi I Nakayama; Shunsuke Ishii
Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.
The Journal of biological chemistry 2008;283(45):30540-8.
2008: Kanae Ohsaki; Katsutaka Oishi; Yuko Kozono; Keiko Nakayama; Keiichi I Nakayama; Norio Ishida
The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2.
Journal of biochemistry 2008;144(5):609-18.
2008: Mimi Tamamori-Adachi; Hiromitsu Takagi; Kimio Hashimoto; Kazumichi Goto; Toshinori Hidaka; Uichi Koshimizu; Kazuhiko Yamada; Ikuko Goto; Yasuhiro Maejima; Mitsuaki Isobe; Keiichi I Nakayama; Norio Inomata; Shigetaka Kitajima
Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase.
Cardiovascular research 2008;80(2):181-90.
2008: Y Ishikawa; I Onoyama; K I Nakayama; Keiichi I Nakayama
Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7.
Oncogene 2008;27(47):6164-74.
2008: Nobutaka Sakae; Nobuyuki Yamasaki; Kiyoyuki Kitaichi; Takaichi Fukuda; Mitsunori Yamada; Hiroo Yoshikawa; Takato Hiranita; Yoshiki Tatsumi; Jun-ichi Kira; Tsuneyuki Yamamoto; Tsuyoshi Miyakawa; Keiichi I Nakayama
Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants.
Human molecular genetics 2008;17(20):3191-203.
2008: Akiko Matsumoto; Toshihiro Kawamoto; Fumihiro Mutoh; Toyohi Isse; Tsunehiro Oyama; Kyoko Kitagawa; Keiichi I Nakayama; Masayoshi Ichiba
Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice.
Pharmacogenetics and genomics 2008;18(10):847-52.
2008: Anupriya Agarwal; Thomas Bumm; Amie S Corbin; Thomas O'Hare; Marc Loriaux; Jonathan VanDyke; Stephanie G Willis; Jutta Deininger; Keiichi I Nakayama; Brian J Druker; Michael W N Deininger
Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease.
Blood 2008;112(5):1960-70.
2008: Michiko Shirane; Masaharu Ogawa; Jun Motoyama; Keiichi I Nakayama
Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse.
Genes to cells : devoted to molecular & cellular mechanisms 2008;13(6):635-51.
2008: Qing Chen; Weilin Xie; Deborah J. Kuhn; Peter M Voorhees; Antonia Lopez-Girona; Derek Mendy; Laura G Corral; Veronique Plantevin Krenitsky; Weiming Xu; Laure Moutouh-de Parseval; David R Webb; Frank Mercurio; Keiichi I Nakayama; Keiko Nakayama; Robert Z Orlowski
Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy.
Blood 2008;111(9):4690-9.
2008: Naoki Shigematsu; Takaichi Fukuda; Tsuneyuki Yamamoto; Tsuyoshi Nishioku; Taku Yamaguchi; Masaru Himeno; Keiichi I Nakayama; Takayuki Tsukuba; Tomoko Kadowaki; Kuniaki Okamoto; Shun Higuchi; Kenji Yamamoto
Association of cathepsin E deficiency with the increased territorial aggressive response of mice.
Journal of neurochemistry 2008;105(4):1394-404.
2008: Akiko Mukai; Emi Mizuno; Kaoru Kobayashi; Masaki Matsumoto; Keiichi I Nakayama; Naomi Kitamura; Masayuki Komada
Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis.
Journal of cell science 2008;121(Pt 8):1325-33.
2008: Sahoko Matsuoka; Yuichi Oike; Ichiro Onoyama; Atsushi Iwama; Fumio Arai; Keiyo Takubo; Yoichi Mashimo; Hideyuki Oguro; Eriko Nitta; Keisuke Ito; Kana Miyamoto; Hiroki Yoshiwara; Kentaro Hosokawa; Yuka Nakamura; Yumiko Gomei; Hiroko Iwasaki; Yasuhide Hayashi; Yumi Matsuzaki; Keiko Nakayama; Yasuo Ikeda; Akira Hata; Shigeru Chiba; Keiichi I Nakayama; Toshio Suda
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.
Genes & development 2008;22(8):986-91.
2008: Shin-Ichiro Inoue; Toshinori Kinoshita; Masaki Matsumoto; Keiichi I Nakayama; Michio Doi; Ken-ichiro Shimazaki
Blue light-induced autophosphorylation of phototropin is a primary step for signaling.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5626-31.
2007: Etsuo Susaki; Keiichi I Nakayama
Multiple mechanisms for p27(Kip1) translocation and degradation.
Cell cycle (Georgetown, Tex.) 2007;6(24):3015-20.
2007: Ichiro Onoyama; Ryosuke Tsunematsu; Akinobu Matsumoto; Taichi Kimura; Ignacio Moreno de Alborán; Keiko Nakayama; Keiichi I Nakayama
Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis.
The Journal of experimental medicine 2007;204(12):2875-88.
2007: Chihiro Ueyama; Hiroki Akashiba; Keiko Nakayama; Keiichi I Nakayama; Nobuyoshi Nishiyama; Norio Matsuki
Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration.
Neuroreport 2007;18(17):1781-5.
2007: Tomoyo Kawakubo; Kuniaki Okamoto; Jun-ichi Iwata; Masashi Shin; Yoshiko Okamoto; Atsushi Yasukochi; Keiichi I Nakayama; Tomoko Kadowaki; Takayuki Tsukuba; Kenji Yamamoto
Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface.
Cancer research 2007;67(22):10869-78.
2007: Camille Ehre; Yunxiang Zhu; Lubna H Abdullah; John C Olsen; Keiichi I Nakayama; Keiko Nakayama; Robert O Messing; C William Davis
nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells.
American journal of physiology. Cell physiology 2007;293(5):C1445-54.
2007: Tomonari Matsuda; Akiko Matsumoto; Mitsuhiro Uchida; Robert A Kanaly; Kentaro Misaki; Shinya Shibutani; Toshihiro Kawamoto; Kyoko Kitagawa; Keiichi I Nakayama; Katsumaro Tomokuni; Masayoshi Ichiba
Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol.
Carcinogenesis 2007;28(11):2363-6.
2007: Hidetoshi Wakeyama; Toru Akiyama; Katsuhiko Takahashi; Hitoshi Amano; Yuho Kadono; Masaki Nakamura; Yasushi Oshima; Hiroyuki Itabe; Keiichi I Nakayama; Keiko Nakayama; Kozo Nakamura; Sakae Tanaka
Negative feedback loop in the Bim-caspase-3 axis regulating apoptosis and activity of osteoclasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(10):1631-9.
2007: Sayuri Suzuki; Hirotaka Fukasawa; Kyoko Kitagawa; Chiharu Uchida; Takayuki Hattori; Tomoyasu Isobe; Toshiaki Oda; Taro Misaki; Naro Ohashi; Keiko Nakayama; Keiichi I Nakayama; Akira Hishida; Tatsuo Yamamoto; Masatoshi Kitagawa
Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice.
The American journal of pathology 2007;171(2):473-83.
2007: Etsuo Susaki; Keiko Nakayama; Keiichi I Nakayama
Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transition.
Molecular and cellular biology 2007;27(13):4626-40.
2007: Kana Miyamoto; Kiyomi Y Araki; Kazuhito Naka; Fumio Arai; Keiyo Takubo; Satoshi Yamazaki; Sahoko Matsuoka; Takeshi Miyamoto; Keisuke Ito; Masako Ohmura; Chen Chen; Kentaro Hosokawa; Hiromitsu Nakauchi; Keiko Nakayama; Keiichi I Nakayama; Mine Harada; Noboru Motoyama; Toshio Suda; Atsushi Hirao
Foxo3a is essential for maintenance of the hematopoietic stem cell pool.
Cell stem cell 2007;1(1):101-12.
2007: Tadashi Nakagawa; Michiko Shirane; Shun-ichiro Iemura; Tohru Natsume; Keiichi I Nakayama
Anchoring of the 26S proteasome to the organellar membrane by FKBP38.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(6):709-19.
2007: Paul S Cooke; Denise R Holsberger; Melissa A Cimafranca; Duane Daryl Meling; Charity M Beals; Keiko Nakayama; Keiichi I Nakayama; Hiroaki Kiyokawa
The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo.
Obesity (Silver Spring, Md.) 2007;15(6):1400-8.
2007: Zhixue Liu; Xia Liu; Keiichi I Nakayama; Keiko Nakayama; Keqiang Ye
Protein kinase C-delta phosphorylates Ebp1 and prevents its proteolytic degradation, enhancing cell survival.
Journal of neurochemistry 2007;100(5):1278-88.
2007: Christine Möller; Mats Karlberg; Magnus Abrink; Keiichi I Nakayama; Noboru Motoyama; Gunnar Nilsson
Bcl-2 and Bcl-XL are indispensable for the late phase of mast cell development from mouse embryonic stem cells.
Experimental hematology 2007;35(3):385-93.
2007: Akiko Mizokami; Takashi Kanematsu; Hitoshi Ishibashi; Taku Yamaguchi; Isei Tanida; Kei Takenaka; Keiichi I Nakayama; Kiyoko Fukami; Tadaomi Takenawa; Eiki Kominami; Stephen J Moss; Tsuneyuki Yamamoto; Junichi Nabekura; Masato Hirata
Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(7):1692-701.
2007: Toyoyoshi Uchida; Noseki Iwashita; Mica Ohara-Imaizumi; Takeshi Ogihara; Shintaro Nagai; Jong Bock Choi; Yoshifumi Tamura; Norihiro Tada; Ryuzo Kawamori; Keiichi I Nakayama; Shinya Nagamatsu; Hirotaka Watada
Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells.
The Journal of biological chemistry 2007;282(4):2707-16.
2007: Michiyo Yanagawa; Takayuki Tsukuba; Tsuyoshi Nishioku; Yoshiko Okamoto; Kuniaki Okamoto; Ryosuke Takii; Yoshihiro Terada; Keiichi I Nakayama; Tomoko Kadowaki; Kenji Yamamoto
Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages.
The Journal of biological chemistry 2007;282(3):1851-62.
2007: Tamon Sakai; Hiroshi Sakaue; Takehiro Nakamura; Mitsuru Okada; Yasushi Matsuki; Eijiro Watanabe; Ryuji Hiramatsu; Keiko Nakayama; Keiichi I Nakayama; Masato Kasuga
Skp2 controls adipocyte proliferation during the development of obesity.
The Journal of biological chemistry 2007;282(3):2038-46.
2007: Yasuhiro Itoh; Norihisa Masuyama; Keiko Nakayama; Keiichi I Nakayama; Yukiko Gotoh
The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex.
The Journal of biological chemistry 2007;282(1):390-6.
2007: Arti Shukla; Karen M Lounsbury; Trisha F Barrett; Joanna Gell; Mercedes Rincon; Kelly J Butnor; Douglas J Taatjes; Gerald S Davis; Pamela M Vacek; Keiichi I Nakayama; Keiko Nakayama; Chad Steele; Brooke T Mossman
Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice.
The American journal of pathology 2007;170(1):140-51.
2007: Xiaolin Tu; Kyu Sang Joeng; Keiichi I Nakayama; Keiko Nakayama; Jayaraj Rajagopal; Thomas J. Carroll; Andrew P McMahon; Fanxin Long
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation.
Developmental cell 2007;12(1):113-27.
2006: Yun Gao; Kyoko Kitagawa; Yoshihiro Hiramatsu; Hirotoshi Kikuchi; Tomoyasu Isobe; Mai Shimada; Chiharu Uchida; Takayuki Hattori; Toshiaki Oda; Keiko Nakayama; Keiichi I Nakayama; Tatsuo Tanaka; Hiroyuki Konno; Masatoshi Kitagawa
Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis.
Cancer research 2006;66(24):11623-31.
2006: Giordano Pula; Kai Schuh; Keiko Nakayama; Keiichi I Nakayama; Ulrich Walter; Alastair W Poole
PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation.
Blood 2006;108(13):4035-44.
2006: Akinobu Matsumoto; Ichiro Onoyama; Keiichi I Nakayama
Expression of mouse Fbxw7 isoforms is regulated in a cell cycle- or p53-dependent manner.
Biochemical and biophysical research communications 2006;350(1):114-9.
2006: Michiko Shirane; Keiichi I Nakayama
Protrudin induces neurite formation by directional membrane trafficking.
Science (New York, N.Y.) 2006;314(5800):818-21.
2006: Kentaro Hara; Keiichi I Nakayama; Keiko Nakayama
Geminin is essential for the development of preimplantation mouse embryos.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(11):1281-93.
2006: Akiko Takahashi; Naoko Ohtani; Kimi Yamakoshi; Shin-ichi Iida; Hidetoshi Tahara; Keiko Nakayama; Keiichi I Nakayama; Toshinori Ide; Hideyuki Saya; Eiji Hara
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.
Nature cell biology 2006;8(11):1291-7.
2006: Yoshihiro Hiramatsu; Kyoko Kitagawa; Toru Suzuki; Chiharu Uchida; Takayuki Hattori; Hirotoshi Kikuchi; Toshiaki Oda; Shigetsugu Hatakeyama; Keiichi I Nakayama; Tadashi Yamamoto; Hiroyuki Konno; Masatoshi Kitagawa
Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination.
Cancer research 2006;66(17):8477-83.
2006: Takashi Kanematsu; Atsushi Yasunaga; Yoshito Mizoguchi; Akiko Kuratani; Josef T Kittler; Jasmina Jovanovic; Kei Takenaka; Keiichi I Nakayama; Kiyoko Fukami; Tadaomi Takenawa; Stephen J Moss; Junichi Nabekura; Masato Hirata
Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition.
The Journal of biological chemistry 2006;281(31):22180-9.
2006: Keiichi I Nakayama; Keiko Nakayama
[Ubiquitin system regulating G1 and S phases of cell cycle].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2006;51(10 Suppl):1362-9.
2006: Ryosuke Tsunematsu; Masaaki Nishiyama; Shuhei Kotoshiba; Toru Saiga; Takumi Kamura; Keiichi I Nakayama
Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development.
Molecular and cellular biology 2006;26(16):6157-69.
2006: Yo Fujii; Masayoshi Yada; Masaaki Nishiyama; Takumi Kamura; Hidehisa Takahashi; Ryosuke Tsunematsu; Etsuo Susaki; Tadashi Nakagawa; Akinobu Matsumoto; Keiichi I Nakayama
Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.
Cancer science 2006;97(8):729-36.
2006: Takayuki Tsukuba; Shinya Yamamoto; Michiyo Yanagawa; Kuniaki Okamoto; Yoshiko Okamoto; Keiichi I Nakayama; Tomoko Kadowaki; Kenji Yamamoto
Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors.
Journal of biochemistry 2006;140(1):57-66.
2006: Arnaud Parcellier; Mathilde Brunet; Elise Schmitt; Edwige Col; Celine Didelot; Arlette Hammann; Keiko Nakayama; Keiichi I Nakayama; Saadi Khochbin; Eric Solary; Carmen Garrido
HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1179-81.
2006: Keiichi I Nakayama; Keiko Nakayama
Ubiquitin ligases: cell-cycle control and cancer.
Nature reviews. Cancer 2006;6(5):369-81.
2006: Shino Niki; Kiyotaka Oshikawa; Yasuhiro Mouri; Fumiko Hirota; Akemi Matsushima; Masashi Yano; Hongwei Han; Yoshimi Bando; Keisuke Izumi; Mitsuru Matsumoto; Keiichi I Nakayama; Noriyuki Kuroda; Mitsuru Matsumoto
Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice.
The Journal of clinical investigation 2006;116(5):1292-301.
2006: Kiyotsugu Yoshida; Tomoko Yamaguchi; Hirokuni Shinagawa; Naoe Taira; Keiichi I Nakayama; Yoshio Miki
Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage.
Molecular and cellular biology 2006;26(9):3414-31.
2006: Arti Shukla; Trisha F Barrett; Keiichi I Nakayama; Kieko Nakayama; Brooke T Mossman; Karen M Lounsbury
Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):997-9.
2006: Eiji Sugihara; Masayuki Kanai; Soichiro Saito; Takayuki Nitta; Hideo Toyoshima; Keiko Nakayama; Keiichi I Nakayama; Kenji Fukasawa; Manfred Schwab; Hideyuki Saya; Masanao Miwa
Suppression of centrosome amplification after DNA damage depends on p27 accumulation.
Cancer research 2006;66(8):4020-9.
2006: Michael J Humphries; Kirsten H Limesand; Jonathan C Schneider; Keiichi I Nakayama; Steven M Anderson; Mary E Reyland
Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo.
The Journal of biological chemistry 2006;281(14):9728-37.
2006: Satoru Kase; Kazuhiko Yoshida; Kazuhiro Ohgami; Kenji Shiratori; Shigeaki Ohno; Keiichi I Nakayama
Phosphorylation of p27(KIP1) in the mitotic cells of the corneal epithelium.
Current eye research 2006;31(4):307-12.
2006: Evan J Ryer; R Patrick Hom; Kenji Sakakibara; Keiichi I Nakayama; Keiko Nakayama; Peter L Faries; Bo Liu; K Kent
PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):780-6.
2006: Ritsuko Iwanaga; Hideyuki Komori; S Ishida; N Okamura; Keiichi I Nakayama; K I Nakayama; Kiyoshi Ohtani
Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners.
Oncogene 2006;25(12):1786-98.
2006: Hideo Nishitani; Nozomi Sugimoto; Vassilis Roukos; Yohsuke Nakanishi; Masafumi Saijo; Chikashi Obuse; Toshiki Tsurimoto; Keiichi I Nakayama; Keiko Nakayama; Masatoshi Fujita; Zoi Lygerou; Takeharu Nishimoto
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
The EMBO journal 2006;25(5):1126-36.
2006: Satoru Kase; Kazuhiko Yoshida; Kazuhiro Ohgami; Kenji Shiratori; Yukari Suzuki; Keiichi I Nakayama; Shigeaki Ohno
Expression of cdc2 and p27(KIP1) phosphorylation in mitotic cells of the human retinoblastoma.
International journal of molecular medicine 2006;17(3):465-8.
2006: Satoru Kase; Kazuhiko Yoshida; Takayuki Harada; Chikako Harada; Kazuhiko Namekata; Yukari Suzuki; Kazuhiro Ohgami; Kenji Shiratori; Keiichi I Nakayama; Shigeaki Ohno
Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2006;244(3):352-8.
2006: Abbas Fotovati; Keiko Nakayama; Keiichi I Nakayama
Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice.
Cell division 2006;1():4.
2005: Satomi Yogosawa; Shigetsugu Hatakeyama; Keiichi I Nakayama; Hiroyuki Miyoshi; Shinichi Kohsaka; Chihiro Akazawa
Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase.
The Journal of biological chemistry 2005;280(50):41619-27.
2005: Chie Kaneko-Oshikawa; Tadashi Nakagawa; Mitsunori Yamada; Hiroo Yoshikawa; Masaki Matsumoto; Masayoshi Yada; Shigetsugu Hatakeyama; Keiko Nakayama; Keiichi I Nakayama
Mammalian E4 is required for cardiac development and maintenance of the nervous system.
Molecular and cellular biology 2005;25(24):10953-64.
2005: Taichi Hara; Takumi Kamura; Shuhei Kotoshiba; Hidehisa Takahashi; Kenichiro Fujiwara; Ichiro Onoyama; Masahiro Shirakawa; Noboru Mizushima; Keiichi I Nakayama
Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle.
Molecular and cellular biology 2005;25(21):9292-303.
2005: Masaki Matsumoto; Shigetsugu Hatakeyama; Koji Oyamada; Yoshiya Oda; Toshihide Nishimura; Keiichi I Nakayama
Large-scale analysis of the human ubiquitin-related proteome.
Proteomics 2005;5(16):4145-51.
2005: Shin-ichiro Hino; Chie Tanji; Keiichi I Nakayama; Akira Kikuchi
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination.
Molecular and cellular biology 2005;25(20):9063-72.
2005: Shigetsugu Hatakeyama; Masashi Watanabe; Yo Fujii; Keiichi I Nakayama
Targeted destruction of c-Myc by an engineered ubiquitin ligase suppresses cell transformation and tumor formation.
Cancer research 2005;65(17):7874-9.
2005: Zhiqiang Chen; Matthew W Foster; Jian Zhang; Lan Mao; Howard A Rockman; Toshihiro Kawamoto; Kyoko Kitagawa; Keiichi I Nakayama; Douglas T Hess; Jonathan S Stamler
An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12159-64.
2005: Satoru Kase; Kazuhiko Yoshida; Keiichi I Nakayama; Keiko Nakayama; Hiromi Ikeda; Takayuki Harada; Chikako Harada; Kazuhiro Ohgami; Kenji Shiratori; Shigeaki Ohno
Phosphorylation of p27(KIP1) in the developing retina and retinoblastoma.
International journal of molecular medicine 2005;16(2):257-62.
2005: Tatiana Pushkarsky; Vyacheslav Yurchenko; Christophe Vanpouille; Beda Brichacek; Iosif Vaisman; Shigetsugu Hatakeyama; Keiichi I Nakayama; Barbara Sherry; Michael Bukrinsky
Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60.
The Journal of biological chemistry 2005;280(30):27866-71.
2005: Hua-Qin Wang; Yoshifumi Nakaya; Zhenyu Du; Takuya Yamane; Michiko Shirane; Takashi Kudo; Masatoshi Takeda; Koichi Takebayashi; Yoichi Noda; Keiichi I Nakayama; Masaki Nishimura
Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2.
Human molecular genetics 2005;14(13):1889-902.
2005: Satoru Kase; Kazuhiko Yoshida; Hiromi Ikeda; Takayuki Harada; Chikako Harada; Junko Imaki; Kazuhiro Ohgami; Kenji Shiratori; Keiichi I Nakayama; Keiko Nakayama; Shigeaki Ohno
Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens.
Current eye research 2005;30(6):437-42.
2005: Keiichi I Nakayama; Keiko Nakayama
Regulation of the cell cycle by SCF-type ubiquitin ligases.
Seminars in cell & developmental biology 2005;16(3):323-33.
2005: Shuhei Kotoshiba; Takumi Kamura; Taichi Hara; Noriko Ishida; Keiichi I Nakayama
Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase.
The Journal of biological chemistry 2005;280(18):17694-700.
2005: Desmond Jackson; Yang Zheng; Donggon Lyo; Yinjie Shen; Keiko Nakayama; Keiichi I Nakayama; Michael J Humphries; Mary E Reyland; David A Foster
Suppression of cell migration by protein kinase Cdelta.
Oncogene 2005;24(18):3067-72.
2005: Chuan Hua He; Aaron B Waxman; Chun Geun Lee; Holger W Link; Morgan E Rabach; Bing Ma; Qingsheng Chen; Zhou Zhu; Mei Zhong; Keiko Nakayama; Keiichi I Nakayama; Robert J Homer; Jack A Elias
Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury.
The Journal of clinical investigation 2005;115(4):1039-48.
2005: Hidehisa Takahashi; Shigetsugu Hatakeyama; Hisato Saitoh; Keiichi I Nakayama
Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein.
The Journal of biological chemistry 2005;280(7):5611-21.
2005: Tohru Uchida; Takehiro Nakamura; Naoko Hashimoto; Tomokazu Matsuda; Ko Kotani; Hiroshi Sakaue; Yoshiaki Kido; Yoshitake Hayashi; Keiichi I Nakayama; Morris F White; Masato Kasuga
Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice.
Nature medicine 2005;11(2):175-82.
2005: Yojiro Kotake; Keiko Nakayama; Noriko Ishida; Keiichi I Nakayama
Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation.
The Journal of biological chemistry 2005;280(2):1095-102.
2005: Geneviève Rodier; Constantin Makris; Philippe Coulombe; Anthony Scime; Keiko Nakayama; Keiichi I Nakayama; Sylvain Meloche
p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2.
The Journal of cell biology 2005;168(1):55-66.
2005: Shigetsugu Hatakeyama; Masaki Matsumoto; Keiichi I Nakayama
Mapping of ubiquitination sites on target proteins.
Methods in enzymology 2005;399():277-86.
2004: Fumihiko Okumura; Shigetsugu Hatakeyama; Masaki Matsumoto; Takumi Kamura; Keiichi I Nakayama
Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.
The Journal of biological chemistry 2004;279(51):53533-43.
2004: Takumi Kamura; Katsumi Maenaka; Shuhei Kotoshiba; Masaki Matsumoto; Daisuke Kohda; Ronald C Conaway; Joan Weliky Conaway; Keiichi I Nakayama
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
Genes & development 2004;18(24):3055-65.
2004: Florian Blaschke; Olli Leppanen; Yasunori Takata; Evren Caglayan; Joey Liu; Michael C Fishbein; Kai Kappert; Keiichi I Nakayama; Alan R Collins; Eckart Fleck; Willa A Hsueh; Ronald E Law; Dennis Bruemmer
Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries.
Circulation research 2004;95(12):e110-23.
2004: Jian-Hua Mao; Jesus Perez-Losada; Di Wu; Reyno DelRosario; Ryosuke Tsunematsu; Keiichi I Nakayama; Ken Brown; Sheila Bryson; Allan Balmain
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.
Nature 2004;432(7018):775-9.
2004: Takumi Kamura; Taichi Hara; Masaki Matsumoto; Noriko Ishida; Fumihiko Okumura; Shigetsugu Hatakeyama; Minoru Yoshida; Keiko Nakayama; Keiichi I Nakayama
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.
Nature cell biology 2004;6(12):1229-35.
2004: Mimi Tamamori-Adachi; Kentaro Hayashida; Kiyoshi Nobori; Chie Omizu; Kazuhiko Yamada; Naoya Sakamoto; Takumi Kamura; Keiichi Fukuda; Satoshi Ogawa; Keiichi I Nakayama; Shigetaka Kitajima
Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4. Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation.
The Journal of biological chemistry 2004;279(48):50429-36.
2004: Shigetsugu Hatakeyama; Masaki Matsumoto; Takumi Kamura; Miyuki Murayama; De-Hua Chui; Emmanuel Planel; Ryosuke Takahashi; Keiichi I Nakayama; Akihiko Takashima
U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy.
Journal of neurochemistry 2004;91(2):299-307.
2004: Masaaki Nishiyama; Keiko Nakayama; Ryosuke Tsunematsu; Tadasuke Tsukiyama; Akira Kikuchi; Keiichi I Nakayama
Early embryonic death in mice lacking the beta-catenin-binding protein Duplin.
Molecular and cellular biology 2004;24(19):8386-94.
2004: Tomoko Komatsu; Hirofumi Mizusaki; Tokuo Mukai; Hidesato Ogawa; Daichi Baba; Masahiro Shirakawa; Shigetsugu Hatakeyama; Keiichi I Nakayama; Hideki Yamamoto; Akira Kikuchi; Ken-ichirou Morohashi
Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9.
Molecular endocrinology (Baltimore, Md.) 2004;18(10):2451-62.
2004: Miho Terunuma; Il-Sung Jang; Sang Hoon Ha; Josef T Kittler; Takashi Kanematsu; Jasmina Jovanovic; Keiichi I Nakayama; Norio Akaike; Sung Ho Ryu; Stephen J Moss; Masato Hirata
GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(32):7074-84.
2004: Hiroko Akiyoshi; Shigetsugu Hatakeyama; Jukka Pitkänen; Yasuhiro Mouri; Vassilis Doucas; Jun Kudoh; Kyoko Tsurugaya; Daisuke Uchida; Akemi Matsushima; Kiyotaka Oshikawa; Keiichi I Nakayama; Nobuyoshi Shimizu; Pärt Peterson; Mitsuru Matsumoto
Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner.
The Journal of biological chemistry 2004;279(32):33984-91.
2004: Baojie Li; Xueying Wang; Naslin Rasheed; Yuanyu Hu; Sharon Boast; Tetsuro Ishii; Keiko Nakayama; Keiichi I Nakayama; Stephen P Goff
Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta.
Genes & development 2004;18(15):1824-37.
2004: Kazuhiko Yoshida; Satoru Kase; Keiko Nakayama; Hiroyasu Nagahama; Takayuki Harada; Hiromi Ikeda; Chikako Harada; Junko Imaki; Kazuhiro Ohgami; Kenji Shiratori; Iliyana Ilieva; Shigeaki Ohno; Shinzo Nishi; Keiichi I Nakayama
Involvement of p27KIP1 in the proliferation of the developing corneal endothelium.
Investigative ophthalmology & visual science 2004;45(7):2163-7.
2004: Shigetsugu Hatakeyama; Masaki Matsumoto; Masayoshi Yada; Keiichi I Nakayama
Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(6):533-48.
2004: Masayoshi Yada; Shigetsugu Hatakeyama; Takumi Kamura; Masaaki Nishiyama; Ryosuke Tsunematsu; Hiroyuki Imaki; Noriko Ishida; Fumihiko Okumura; Keiko Nakayama; Keiichi I Nakayama
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
The EMBO journal 2004;23(10):2116-25.
2004: Keiko Nakayama; Hiroyasu Nagahama; Yoji Andrew MINAMISHIMA; Satoshi Miyake; Noriko Ishida; Shigetsugu Hatakeyama; Masatoshi Kitagawa; Shun-ichiro Iemura; Tohru Natsume; Keiichi I Nakayama
Skp2-mediated degradation of p27 regulates progression into mitosis.
Developmental cell 2004;6(5):661-72.
2004: Kwang-Jin Oh; Anna Kalinina; Jing Wang; Keiko Nakayama; Keiichi I Nakayama; Srilata Bagchi
The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin 1- and Skp2-containing E3 ligase.
Journal of virology 2004;78(10):5338-46.
2004: Kazuhiko Yoshida; Satoru Kase; Keiko Nakayama; Hiroyasu Nagahama; Takayuki Harada; Hiromi Ikeda; Chikako Harada; Junko Imaki; Kazuhiro Ohgami; Kenji Shiratori; Shigeaki Ohno; Keiichi I Nakayama
Distribution of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal detachment.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2004;242(5):437-41.
2004: Kazuhiko Yoshida; Keiko Nakayama; Satoru Kase; Hiroyasu Nagahama; Takayuki Harada; Hiromi Ikeda; Chikako Harada; Junko Imaki; Kazuhiro Ohgami; Kenji Shiratori; Shigeaki Ohno; Shinzo Nishi; Keiichi I Nakayama
Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body.
Anatomy and embryology 2004;208(2):145-50.
2004: Ryosuke Tsunematsu; Keiko Nakayama; Yuichi Oike; Masaaki Nishiyama; Noriko Ishida; Shigetsugu Hatakeyama; Yasumasa Bessho; Ryoichiro Kageyama; Toshio Suda; Keiichi I Nakayama
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
The Journal of biological chemistry 2004;279(10):9417-23.
2004: Masaki Matsumoto; Masayoshi Yada; Shigetsugu Hatakeyama; Hiroshi Ishimoto; Teiichi Tanimura; Shoji Tsuji; Akira Kakizuka; Masatoshi Kitagawa; Keiichi I Nakayama
Molecular clearance of ataxin-3 is regulated by a mammalian E4.
The EMBO journal 2004;23(3):659-69.
2004: Michiko Shirane; Keiichi I Nakayama
[Immunophilin FKBP38, an inherent inhibitor of calcineurin, targets Bcl-2 to mitochondria and inhibits apoptosis].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(2):405-12.
2004: Takao Ohtsuka; Hoon Ryu; Yoji Andrew MINAMISHIMA; Salvador Macip; Junji Sagara; Keiichi I Nakayama; Stuart A Aaronson; Sam W Lee
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.
Nature cell biology 2004;6(2):121-8.
2004: Daisuke Uchida; Shigetsugu Hatakeyama; Akemi Matsushima; Hongwei Han; Satoshi Ishido; Hak Hotta; Jun Kudoh; Nobuyoshi Shimizu; Vassilis Doucas; Keiichi I Nakayama; Noriyuki Kuroda; Mitsuru Matsumoto
AIRE functions as an E3 ubiquitin ligase.
The Journal of experimental medicine 2004;199(2):167-72.
2003: Takayuki Tsukuba; Kuniaki Okamoto; Yoshiko Okamoto; Michiyo Yanagawa; Keiko Kohmura; Yoshiyuki Yasuda; Hiroshi Uchi; Takeshi Nakahara; masutaka furue; Keiko Nakayama; Tomoko Kadowaki; Kenji Yamamoto; Keiichi I Nakayama
Association of cathepsin E deficiency with development of atopic dermatitis.
Journal of biochemistry 2003;134(6):893-902.
2003: Tong-Shin Chang; Myung Jin Kim; Kanghyun Ryoo; Jihyun Park; Soo-Jung Eom; Jaekyung Shim; Keiichi I Nakayama; Keiko Nakayama; Motowo Tomita; Katsuhiko Takahashi; Min-Jae Lee; Eui-Ju Choi
p57KIP2 modulates stress-activated signaling by inhibiting c-Jun NH2-terminal kinase/stress-activated protein Kinase.
The Journal of biological chemistry 2003;278(48):48092-8.
2003: Kazuhiko Yoshida; Takayuki Harada; Chikako Harada; Satoru Kase; Hiromi Ikeda; Masaharu Sakai; Shinzo Nishi; Junko Imaki; Keiko Nakayama; Hiroyasu Nagahama; Keiichi I Nakayama; Shigeaki Ohno
[Proliferative regulation in the cornea and lens].
Nippon Ganka Gakkai zasshi 2003;107(11):678-86.
2003: James S Foster; Romaine I Fernando; Noriko Ishida; Keiichi I Nakayama; Jay Wimalasena
Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway.
The Journal of biological chemistry 2003;278(42):41355-66.
2003: Takumi Kamura; Taichi Hara; Shuhei Kotoshiba; Masayoshi Yada; Noriko Ishida; Hiroyuki Imaki; Shigetsugu Hatakeyama; Keiko Nakayama; Keiichi I Nakayama
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10231-6.
2003: Hiroyuki Imaki; Keiko Nakayama; Sophie Delehouzee; Hiroshi Handa; Masatoshi Kitagawa; Takumi Kamura; Keiichi I Nakayama
Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein.
Cancer research 2003;63(15):4607-13.
2003: Keiko Nakayama; Shigetsugu Hatakeyama; Shun-ichiro Maruyama; Akira Kikuchi; Kazunori Onoé; Robert A Good; Keiichi I Nakayama
Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8752-7.
2003: Shigetsugu Hatakeyama; Keiichi I Nakayama
Ubiquitylation as a quality control system for intracellular proteins.
Journal of biochemistry 2003;134(1):1-8.
2003: Natalie von der Lehr; Sara Johansson; Siqin Wu; Fuad Bahram; Alina Castell; Cihan Cetinkaya; Per Hydbring; Ingrid Weidung; Keiko Nakayama; Keiichi I Nakayama; Ola Söderberg; Tom K Kerppola; Lars-Gunnar Larsson
The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.
Molecular cell 2003;11(5):1189-200.
2003: Kiyotaka Oshikawa; Masaki Matsumoto; Masayoshi Yada; Takumi Kamura; Shigetsugu Hatakeyama; Keiichi I Nakayama
Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1.
Biochemical and biophysical research communications 2003;303(4):1209-16.
2003: Yohei Seto; Hiroshi Nakajima; Akira Suto; Kazuya Shimoda; Yasushi Saito; Keiichi I Nakayama; Itsuo Iwamoto
Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):1077-83.
2003: Chie Kaneko; Shigetsugu Hatakeyama; Masaki Matsumoto; Masayoshi Yada; Keiko Nakayama; Keiichi I Nakayama
Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a.
Biochemical and biophysical research communications 2003;300(2):297-304.
2003: Michiko Shirane; Keiichi I Nakayama
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.
Nature cell biology 2003;5(1):28-37.
2002: Shinsuke Tomari; Hiroyasu Nagahama; Yujing Shu; Sachi Hoshi; Keiko Nakayama; Keiichi I Nakayama; Michio Nagata
Glomerular differentiation in p27 and p57 double-mutant metanephroi.
Anatomy and embryology 2002;206(1-2):31-6.
2002: Luis F García-Fernández; Alejandro Losada; Victoria Alcaide; Alberto M Alvarez; Antonio Cuadrado; Laura González; Keiko Nakayama; Keiichi I Nakayama; José María Fernández-Sousa; Alberto Muñoz; José María Sánchez-Puelles
Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta.
Oncogene 2002;21(49):7533-44.
2002: Ikuo Nakamichi; Shigetsugu Hatakeyama; Keiichi I Nakayama
Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18.
Molecular biology of the cell 2002;13(10):3441-51.
2002: Noriko Ishida; Taichi Hara; Takumi Kamura; Minoru Yoshida; Keiko Nakayama; Keiichi I Nakayama
Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export.
The Journal of biological chemistry 2002;277(17):14355-8.
2002: Akimoto Miyamoto; Keiko Nakayama; Hiroyuki Imaki; Sachiko Hirose; Yi Jiang; Masaaki Abe; Tadasuke Tsukiyama; Hiroyasu Nagahama; Shigeo Ohno; Shigetsugu Hatakeyama; Keiichi I Nakayama
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta.
Nature 2002;416(6883):865-9.
1999: Keiichi I Nakayama; Takahiko Hara; Masahiko Hibi; Toshio Hirano; Atsushi Miyajima
A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth.
The Journal of biological chemistry 1999;274(35):24766-72.
1998: Michio Nagata; Keiichi I Nakayama; Y Terada; Sachi Hoshi; T Watanabe
Cell cycle regulation and differentiation in the human podocyte lineage.
The American journal of pathology 1998;153(5):1511-20.
1998: Tomoaki Tanaka; Ichiro Tatsuno; Yoshihiko Noguchi; D Uchida; T Oeda; S Narumiya; Tatsuji Yasuda; H Higashi; Motoo Kitagawa; Keiichi I Nakayama; Yasushi Saito; Akira Hirai
Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression.
The Journal of biological chemistry 1998;273(41):26772-8.
1997: Y Kodama; Keiichi I Nakayama; H Fuse; Seiji Fukumoto; H Kawahara; H Takahashi; T Kurokawa; Chiharu Sekiguchi; Tetsuya Nakamura; Toshio Matsumoto
Inhibition of bone resorption by pamidronate cannot restore normal gain in cortical bone mass and strength in tail-suspended rapidly growing rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(7):1058-67.