FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Luigi Naldini

Research Profile

Living Beings

Chemicals & Drugs

Procedures

Physiology

Transduction, Genetic

Devices

Gene Transfer Techniques

Anatomy

Genes & Molecular Sequences

Transgenes

Phenomena

Virus Integration

Disorders

Co-author Network

Publications

TOP 3
Andrea Annoni; Kevin Goudy; Luigi Naldini; Mahzad Akbarpour; Maria Grazia Roncarolo
Immune responses in liver-directed lentiviral gene therapy.
Marco Ranzani; Francesca Sanvito; Manfred Schmidt; Lucia Sergi Sergi; Giovanni Tonon; Christof von Kalle; Luigi Naldini; Mauro Pala; Cynthia C Bartholomae; Fabrizio Benedicenti; Alessandro Bulfone; Daniela Cesana; Claudio Doglioni; Pierangela Gallina; Yoon Jun Kim; Stefania Merella; Eugenio Montini
Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer.
Samantha Scaramuzza; Manfred Schmidt; Elisa Vicenzi; Anna Villa; Christof von Kalle; Cynthia C Bartholomae; Fabrizio Benedicenti; Luca Biasco; Alessandra Biffi; Marita Bosticardo; Robbert Bredius; Maria C Castiello; Elena Draghici; Andrea Finocchi; Raisa J Hernandez; Mariana Loperfido; Eugenio Montini; Luigi Naldini; Marina Radrizzani; Marco Ranzani; Anna Ripamonti; Maria-Grazia Roncarolo; Monica Salomoni; Alessandro Aiuti
Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Luigi Naldini (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Andrea Annoni; Kevin Goudy; Luigi Naldini; Mahzad Akbarpour; Maria Grazia Roncarolo
Immune responses in liver-directed lentiviral gene therapy.
Translational research : the journal of laboratory and clinical medicine 2013;161(4):230-40.
2013: Marco Ranzani; Francesca Sanvito; Manfred Schmidt; Lucia Sergi Sergi; Giovanni Tonon; Christof von Kalle; Luigi Naldini; Mauro Pala; Cynthia C Bartholomae; Fabrizio Benedicenti; Alessandro Bulfone; Daniela Cesana; Claudio Doglioni; Pierangela Gallina; Yoon Jun Kim; Stefania Merella; Eugenio Montini
Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer.
Nature methods 2013;10(2):155-61.
2013: Samantha Scaramuzza; Manfred Schmidt; Elisa Vicenzi; Anna Villa; Christof von Kalle; Cynthia C Bartholomae; Fabrizio Benedicenti; Luca Biasco; Alessandra Biffi; Marita Bosticardo; Robbert Bredius; Maria C Castiello; Elena Draghici; Andrea Finocchi; Raisa J Hernandez; Mariana Loperfido; Eugenio Montini; Luigi Naldini; Marina Radrizzani; Marco Ranzani; Anna Ripamonti; Maria-Grazia Roncarolo; Monica Salomoni; Alessandro Aiuti
Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(1):175-84.
2012: Alessio Cantore; Marinee Chuah; Armando D'Angelo; Patrizia Della Valle; Mario Di Matteo; Clelia Di Serio; Janka Màtrai; Nisha Nair; Luigi Naldini; Francesca Sanvito; Chiara Brombin; Thierry Vandendriessche
Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice.
Blood 2012;120(23):4517-20.
2012: Alessia Capotondo; Clelia Di Serio; Stefania Merella; Rita Milazzo; Eugenio Montini; Luigi Naldini; Alessandro Nonis; Alessio Palini; Tiziana Plati; Letterio Salvatore Politi; Angelo Quattrini; Alessandra Biffi
Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(37):15018-23.
2012: Elena Provasi; Andreas Reik; Lei Zhang; Attilio Bondanza; Claudio Bordignon; Barbara Camisa; Giulia Casorati; Victoria Chu; Fabio Ciceri; Pietro Genovese; Philip D Greenberg; Philip D Gregory; Michael C Holmes; Jurgen Kuball; Pei-Qi Liu; Angelo Lombardo; Zulma Magnani; Luigi Naldini; David E Paschon; Maurilio Ponzoni; Chiara Bonini
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer.
Nature medicine 2012;18(5):807-15.
2011: Laura Passerini; Maria G Roncarolo; Alberto Tommasini; Silvia Vignola; Mario Abinun; Mario Amendola; Federica Barzaghi; Massimiliano Cecconi; Marco Cipolli; Sara Di Nunzio; Luisa Guidi; Sophie Hambleton; Luigi Naldini; Sven Olek; Rosa Bacchetta
Forkhead box protein 3 (FOXP3) mutations lead to increased TH17 cell numbers and regulatory T-cell instability.
The Journal of allergy and clinical immunology 2011;128(6):1376-1379.e1.
2011: Laura E Perlini; Mario Amendola; Fabio Benfenati; Dario Bonanomi; Francesca Botti; Eugenio Fornasiero; Maila Giannandrea; Luigi Naldini; Flavia Valtorta
Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I.
Journal of cell science 2011;124(Pt 21):3643-53.
2011: Bruno Di Stefano; Bernhard Gentner; Sara Martina Maffioletti; Luigi Naldini; Giulia Schira; Federica Ungaro; Vania Broccoli
A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells.
Stem cells (Dayton, Ohio) 2011;29(11):1684-95.
2011: Margherita Neri; Aldo Orlacchio; Alessandra Ricca; Sabata Martino; Luigi Naldini; Beatriz Alcala'-Franco; Chiara Cavazzin; Ilaria di Girolamo; Angela Gritti
Neural stem cell gene therapy ameliorates pathology and function in a mouse model of globoid cell leukodystrophy.
Stem cells (Dayton, Ohio) 2011;29(10):1559-71.
2011: Michele De Palma; Luigi Naldini
Angiopoietin-2 TIEs up macrophages in tumor angiogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(16):5226-32.
2011: Marita Bosticardo; Elena Draghici; Francesca Schena; Aisha Vanessa Sauer; Elena Fontana; Maria Carmina Castiello; Marco Catucci; Michela Locci; Luigi Naldini; Alessandro Aiuti; Maria-Grazia Roncarolo; Pietro Luigi Poliani; Elisabetta Traggiai; Anna Villa
Lentiviral-mediated gene therapy leads to improvement of B-cell functionality in a murine model of Wiskott-Aldrich syndrome.
The Journal of allergy and clinical immunology 2011;127(6):1376-84.e5.
2011: Alessandra Biffi; Cynthia C Bartolomae; Daniela Cesana; Natalie Cartier; Patrik Aubourg; Marco Ranzani; Martina Cesani; Fabrizio Benedicenti; Tiziana Plati; Enrico Rubagotti; Stefania Merella; Alessia Capotondo; Jacopo Sgualdino; Gianluigi Zanetti; Christof von Kalle; Manfred Schmidt; Luigi Naldini; Enrica Montini
Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection.
Blood 2011;117(20):5332-9.
2011: Janka Mátrai; Alessio Cantore; Cynthia C Bartholomae; Andrea Annoni; Wei Wang; Abel Acosta-Sanchez; Ermira Samara-Kuko; Liesbeth De Waele; Ling Ma; Pietro Genovese; Martina Damo; Anne Arens; Kevin Goudy; Timothy C Nichols; Christof von Kalle; Marinee K L Chuah; Maria Grazia Roncarolo; Manfred Schmidt; Thierry VandenDriessche; Luigi Naldini
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk.
Hepatology (Baltimore, Md.) 2011;53(5):1696-707.
2011: Roberta Mazzieri; Ferdinando Pucci; Davide Moi; Erika Zonari; Anna Ranghetti; Alvise Berti; Letterio S Politi; Bernhard Gentner; Jeffrey L Brown; Luigi Naldini; Michele De Palma
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.
Cancer cell 2011;19(4):512-26.
2011: Andrea Casazza; Xi Fu; Irja Johansson; Lorena Capparuccia; Fredrik Andersson; Alice Giustacchini; Mario Leonardo Squadrito; Mary Anna Venneri; Massimiliano Mazzone; Erik Larsson; Peter Carmeliet; Michele De Palma; Luigi Naldini; Luca Tamagnone; Charlotte Rolny
Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(4):741-9.
2011: Maura Rossetti; Silvia Gregori; Ehud Hauben; Brian D Brown; Lucia Sergi Sergi; Luigi Naldini; Maria-Grazia Roncarolo
HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells.
Human gene therapy 2011;22(2):177-88.
2011: Kevin Scott Goudy; Luigi Naldini; Andrea Annoni; Maria-Grazia Roncarolo
Manipulating Immune Tolerance with Micro-RNA Regulated Gene Therapy.
Frontiers in microbiology 2011;2():221.
2011: Angelo Lombardo; Zulma Magnani; Margherita Neri; Oscar M Pello; Elena Provasi; Chiara Bonini; Vania Broccoli; Alessio Cantore; Daniela Cesana; Daniele F Colombo; Martina Damo; Bruno Di Stefano; Pietro Genovese; Philip D Gregory; Angela Gritti; Michael C Holmes; Pietro Lo Riso; Luigi Naldini
Site-specific integration and tailoring of cassette design for sustainable gene transfer.
Nature methods 2011;8(10):861-9.
2010: Ilaria Visigalli; Stefania Delai; Letterio S Politi; Carmela Di Domenico; Federica Cerri; Emanuela Mrak; Raffaele D'Isa; Daniela Ungaro; Merel Stok; Francesca Sanvito; Elisabetta Mariani; Lidia Staszewsky; Claudia Godi; Ilaria Russo; Francesca Cecere; Ubaldo Del Carro; Alessandro Rubinacci; Riccardo Brambilla; Angelo Quattrini; Paola Di Natale; Katherine Ponder; Luigi Naldini; Alessandra Biffi
Gene therapy augments the efficacy of hematopoietic cell transplantation and fully corrects mucopolysaccharidosis type I phenotype in the mouse model.
Blood 2010;116(24):5130-9.
2010: Bernhard Gentner; Ilaria Visigalli; Hidefumi Hiramatsu; Eric Lechman; Silvia Ungari; Alice Giustacchini; Giulia Schira; Mario Amendola; Angelo Quattrini; Sabata Martino; Aldo Orlacchio; John E Dick; Alessandra Biffi; Luigi Naldini
Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy.
Science translational medicine 2010;2(58):58ra84.
2010: Ilaria Visigalli; Silvia Ungari; Sabata Martino; Hyejung Park; Martina Cesani; Bernhard Gentner; Lucia Sergi Sergi; Aldo Orlacchio; Luigi Naldini; Alessandra Biffi
The galactocerebrosidase enzyme contributes to the maintenance of a functional hematopoietic stem cell niche.
Blood 2010;116(11):1857-66.
2010: Annalisa Lattanzi; Margherita Neri; Claudio Maderna; Ilaria di Girolamo; Sabata Martino; Aldo Orlacchio; Mario Amendola; Luigi Naldini; Angela Gritti
Widespread enzymatic correction of CNS tissues by a single intracerebral injection of therapeutic lentiviral vector in leukodystrophy mouse models.
Human molecular genetics 2010;19(11):2208-27.
2010: Michele De Palma; Luigi Naldini
Antagonizing metastasis.
Nature biotechnology 2010;28(4):331-2.
2009: Andrea Annoni; Brian D Brown; Alessio Cantore; Lucia Sergi Sergi; Luigi Naldini; Maria-Grazia Roncarolo
In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance.
Blood 2009;114(25):5152-61.
2009: Luigi Naldini
Medicine. A comeback for gene therapy.
Science (New York, N.Y.) 2009;326(5954):805-6.
2009: Barbara Cassani; Enrica Montini; giulietta maruggi; alessandro ambrosi; Massimiliano Mirolo; Silvia Selleri; Erika Biral; Ilaria Frugnoli; Vivian Hernandez-Trujillo; Clelia Di Serio; Maria-Grazia Roncarolo; Luigi Naldini; Fulvio Mavilio; Alessandro Aiuti
Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy.
Blood 2009;114(17):3546-56.
2009: Tiziana Plati; Ilaria Visigalli; Alessia Capotondo; Mario Buono; Luigi Naldini; Maria Pia Cosma; Alessandra Biffi
Development and maturation of invariant NKT cells in the presence of lysosomal engulfment.
European journal of immunology 2009;39(10):2748-54.
2009: Martina Cesani; Alessia Capotondo; Tiziana Plati; Lucia Sergi Sergi; Francesca Fumagalli; Maria-Grazia Roncarolo; Luigi Naldini; Giancarlo Comi; Maria Sessa; Alessandra Biffi
Characterization of new arylsulfatase A gene mutations reinforces genotype-phenotype correlation in metachromatic leukodystrophy.
Human mutation 2009;30(10):E936-45.
2009: Michele De Palma; Luigi Naldini
Tie2-expressing monocytes (TEMs): novel targets and vehicles of anticancer therapy?
Biochimica et biophysica acta 2009;1796(1):5-10.
2009: Ferdinando Pucci; Mary Anna Venneri; Daniela Biziato; Alessandro Nonis; Davide Moi; Antonio Sica; Clelia Di Serio; Luigi Naldini; Michele De Palma
A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships.
Blood 2009;114(4):901-14.
2009: Mario Amendola; Laura Passerini; Ferdinando Pucci; Bernhard Gentner; Rosa Bacchetta; Luigi Naldini
Regulated and multiple miRNA and siRNA delivery into primary cells by a lentiviral platform.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(6):1039-52.
2009: Francesco Marangoni; Marita Bosticardo; Sabine Charrier; Elena Draghici; Michela Locci; Samantha Scaramuzza; Cristina Panaroni; Maurilio Ponzoni; Francesca Sanvito; Claudio Doglioni; Marie Liabeuf; Bernard Gjata; Marie Montus; Katherine Siminovitch; Alessandro Aiuti; Luigi Naldini; Loic DUPRE; Maria-Grazia Roncarolo; Anne Galy; Anna Villa
Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical models.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(6):1073-82.
2009: Ilaria Visigalli; Rosa Maria Moresco; Sara Belloli; Letterio S Politi; Angela Gritti; Daniela Ungaro; Mario Matarrese; Elia Turolla; Andrea Falini; Giuseppe Scotti; Luigi Naldini; Ferruccio Fazio; Alessandra Biffi
Monitoring disease evolution and treatment response in lysosomal disorders by the peripheral benzodiazepine receptor ligand PK11195.
Neurobiology of disease 2009;34(1):51-62.
2009: Eugenio Montini; Daniela Cesana; Manfred Schmidt; Francesca Sanvito; Cynthia C Bartholomae; Marco Ranzani; Fabrizio Benedicenti; Lucia Sergi Sergi; alessandro ambrosi; Maurilio Ponzoni; Claudio Doglioni; Clelia Di Serio; Christof von Kalle; Luigi Naldini
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.
The Journal of clinical investigation 2009;119(4):964-75.
2009: Bernhard Gentner; Giulia Schira; Alice Giustacchini; Mario Amendola; Brian D Brown; Maurilio Ponzoni; Luigi Naldini
Stable knockdown of microRNA in vivo by lentiviral vectors.
Nature methods 2009;6(1):63-6.
2008: Michele De Palma; Roberta Mazzieri; Letterio S Politi; Ferdinando Pucci; Erika Zonari; Giovanni Sitia; Stefania Mazzoleni; Davide Moi; Mary Anna Venneri; Stefano Indraccolo; Andrea Falini; Luca G Guidotti; Rossella Galli; Luigi Naldini
Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis.
Cancer cell 2008;14(4):299-311.
2008: Francesca Romana Santoni de Sio; Angela Gritti; Paolo Cascio; Margherita Neri; Maurilio Sampaolesi; Cesare Galli; Jeremy Luban; Luigi Naldini
Lentiviral vector gene transfer is limited by the proteasome at postentry steps in various types of stem cells.
Stem cells (Dayton, Ohio) 2008;26(8):2142-52.
2008: Sarah E Allan; Alicia N Alstad; Natacha Merindol; Natasha K Crellin; Mario Amendola; Rosa Bacchetta; Luigi Naldini; Maria-Grazia Roncarolo; Hugo Soudeyns; Megan K Levings
Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):194-202.
2007: Brian D Brown; Alessio Cantore; Andrea Annoni; Lucia Sergi Sergi; Angelo Lombardo; Patrizia Della Valle; Armando D'Angelo; Luigi Naldini
A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice.
Blood 2007;110(13):4144-52.
2007: Brian D Brown; Bernhard Gentner; Alessio Cantore; Silvia Colleoni; Mario Amendola; Anna Zingale; Alessia Baccarini; Giovanna Lazzari; Cesare Galli; Luigi Naldini
Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state.
Nature biotechnology 2007;25(12):1457-67.
2007: Michele De Palma; Craig Murdoch; Mary Anna Venneri; Luigi Naldini; Claire E Lewis
Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications.
Trends in immunology 2007;28(12):519-24.
2007: Angelo Lombardo; Pietro Genovese; Christian M Beausejour; Silvia Colleoni; Ya-Li Lee; Kenneth A Kim; Dale Ando; Fyodor D Urnov; Cesare Galli; Philip D Gregory; Michael C Holmes; Luigi Naldini
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery.
Nature biotechnology 2007;25(11):1298-306.
2007: Claire E Lewis; Michele De Palma; Luigi Naldini
Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2.
Cancer research 2007;67(18):8429-32.
2007: Andrea Annoni; Manuela Battaglia; Antonia Follenzi; Angelo Lombardo; Lucia Sergi Sergi; Luigi Naldini; Maria-Grazia Roncarolo
The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4+CD25+ regulatory T cells.
Blood 2007;110(6):1788-96.
2007: A Capotondo; M Cesani; Stefano Pepe; Stefania Fasano; Silvia Gregori; L Tononi; Mary Anna Venneri; Riccardo Brambilla; Angelo Quattrini; Andrea Ballabio; Maria Pia Cosma; Luigi Naldini; Alessandra Biffi
Safety of arylsulfatase A overexpression for gene therapy of metachromatic leukodystrophy.
Human gene therapy 2007;18(9):821-36.
2007: Alessandra Biffi; Luigi Naldini
Novel candidate disease for gene therapy: metachromatic leukodystrophy.
Expert opinion on biological therapy 2007;7(8):1193-205.
2007: Mary Anna Venneri; Michele De Palma; Maurilio Ponzoni; Ferdinando Pucci; Cristina Scielzo; Erika Zonari; Roberta Mazzieri; Claudio Doglioni; Luigi Naldini
Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.
Blood 2007;109(12):5276-85.
2007: Alessandro Fraldi; Alessandra Biffi; Alessia Lombardi; Ilaria Visigalli; Stefano Pepe; Carmine Settembre; Edoardo Nusco; Alberto Auricchio; Luigi Naldini; Andrea Ballabio; Maria Pia Cosma
SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies.
The Biochemical journal 2007;403(2):305-12.
2007: Brian D Brown; Giovanni Sitia; Andrea Annoni; Ehud Hauben; Lucia Sergi Sergi; Anna Zingale; Maria-Grazia Roncarolo; Luca G Guidotti; Luigi Naldini
In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance.
Blood 2007;109(7):2797-805.
2006: Alessandra Biffi; Alessia Capotondo; Stefania Fasano; Ubaldo Del Carro; Sergio Marchesini; Hisaya Azuma; Mariachiara Malaguti; Stefano Amadio; Riccardo Brambilla; Markus Grompe; Claudio Bordignon; Angelo Quattrini; Luigi Naldini
Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice.
The Journal of clinical investigation 2006;116(11):3070-82.
2006: Carmela Di Domenico; D Di Napoli; Enrico Gonzalez Y Reyero; Angelo Lombardo; Luigi Naldini; Paola Di Natale
Limited transgene immune response and long-term expression of human alpha-L-iduronidase in young adult mice with mucopolysaccharidosis type I by liver-directed gene therapy.
Human gene therapy 2006;17(11):1112-21.
2006: Alessandra Mortellaro; Raisa Jofra Hernandez; Matteo M Guerrini; Filippo Carlucci; Antonella Tabucchi; Maurilio Ponzoni; Francesca Sanvito; Claudio Doglioni; Clelia Di Serio; Luca Biasco; Antonia Follenzi; Luigi Naldini; Claudio Bordignon; Maria-Grazia Roncarolo; Alessandro Aiuti
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects.
Blood 2006;108(9):2979-88.
2006: Michele De Palma; Luigi Naldini
Role of haematopoietic cells and endothelial progenitors in tumour angiogenesis.
Biochimica et biophysica acta 2006;1766(1):159-66.
2006: Diego Dolcetta; Laura Perani; Maria I Givogri; Francesca Galbiati; Stefano Amadio; Ubaldo Del Carro; G Finocchiaro; Alessandro Fanzani; Sergio Marchesini; Luigi Naldini; Maria-Grazia Roncarolo; Ernesto R Bongarzone
Design and optimization of lentiviral vectors for transfer of GALC expression in Twitcher brain.
The journal of gene medicine 2006;8(8):962-71.
2006: Eugenio Montini; Daniela Cesana; Manfred Schmidt; Francesca Sanvito; Maurilio Ponzoni; Cynthia Bartholomae; Lucia Sergi Sergi; Fabrizio Benedicenti; alessandro ambrosi; Clelia Di Serio; Claudio Doglioni; Christof von Kalle; Luigi Naldini
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration.
Nature biotechnology 2006;24(6):687-96.
2006: Francesca Romana Santoni de Sio; Paolo Cascio; Anna Zingale; Mauro Gasparini; Luigi Naldini
Proteasome activity restricts lentiviral gene transfer into hematopoietic stem cells and is down-regulated by cytokines that enhance transduction.
Blood 2006;107(11):4257-65.
2006: Salvatore Patanè; Sofia Avnet; Nadia Coltella; Barbara Costa; Simone Sponza; Martina Olivero; Elisa Vigna; Luigi Naldini; Nicola Baldini; Riccardo Ferracini; Simona Corso; silvia giordano; paolo comoglio; Maria Flavia Di Renzo
MET overexpression turns human primary osteoblasts into osteosarcomas.
Cancer research 2006;66(9):4750-7.
2006: Brian D Brown; Mary Anna Venneri; Anna Zingale; Lucia Sergi Sergi; Luigi Naldini
Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer.
Nature medicine 2006;12(5):585-91.
2006: Loic DUPRE; Francesco Marangoni; Samantha Scaramuzza; Sara Trifari; Raisa Jofra Hernández; Alessandro Aiuti; Luigi Naldini; Maria-Grazia Roncarolo
Efficacy of gene therapy for Wiskott-Aldrich syndrome using a WAS promoter/cDNA-containing lentiviral vector and nonlethal irradiation.
Human gene therapy 2006;17(3):303-13.
2006: Chiara Vantaggiato; Ivan Formentini; Attilio Bondanza; Chiara Bonini; Luigi Naldini; Riccardo Brambilla
ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially.
Journal of biology 2006;5(5):14.
2005: Alessandra Biffi; Luigi Naldini
Gene therapy of storage disorders by retroviral and lentiviral vectors.
Human gene therapy 2005;16(10):1133-42.
2005: Tonia Luca; Maria I Givogri; Laura Perani; Francesca Galbiati; Antonia Follenzi; Luigi Naldini; Ernesto R Bongarzone
Axons mediate the distribution of arylsulfatase A within the mouse hippocampus upon gene delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(4):669-79.
2005: Michele De Palma; Mary Anna Venneri; Rossella Galli; Lucia Sergi Sergi; Letterio S Politi; Maurilio Sampaolesi; Luigi Naldini
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.
Cancer cell 2005;8(3):211-26.
2005: Evelyn Abordo-Adesida; Antonia Follenzi; Carlos Barcia; Sandra A Sciascia; Maria G Castro; Luigi Naldini; Pedro R Lowenstein
Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses.
Human gene therapy 2005;16(6):741-51.
2005: Paola Di Natale; Carmela Di Domenico; Nadia Gargiulo; Sigismondo Castaldo; Enrico Gonzalez Y Reyero; Pratibha Mithbaokar; Mario De Felice; Antonia Follenzi; Luigi Naldini; Guglielmo R D Villani
Treatment of the mouse model of mucopolysaccharidosis type IIIB with lentiviral-NAGLU vector.
The Biochemical journal 2005;388(Pt 2):639-46.
2005: Elisa Vigna; Mario Amendola; Fabrizio Benedicenti; Andrew D Simmons; Antonia Follenzi; Luigi Naldini
Efficient Tet-dependent expression of human factor IX in vivo by a new self-regulating lentiviral vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(5):763-75.
2005: Riccardo Taulli; Paolo Accornero; Antonia Follenzi; Tony Mangano; Alessandro Morotti; Claudio Scuoppo; Paolo Forni; Francesca Bersani; crepaldi tiziana; Roberto Chiarle; Luigi Naldini; Carola Ponzetto
RNAi technology and lentiviral delivery as a powerful tool to suppress Tpr-Met-mediated tumorigenesis.
Cancer gene therapy 2005;12(5):456-63.
2005: Alessandro Cignetti; Antonella Vallario; Antonia Follenzi; Paola Circosta; Antonio Capaldi; Daniela Gottardi; Luigi Naldini; Federico Caligaris-Cappio
Lentiviral transduction of primary myeloma cells with CD80 and CD154 generates antimyeloma effector T cells.
Human gene therapy 2005;16(4):445-56.
2005: Carla Boccaccio; Gabriella Sabatino; Enzo Medico; Flavia Girolami; Antonia Follenzi; Gigliola Reato; Antonino Sottile; Luigi Naldini; paolo comoglio
The MET oncogene drives a genetic programme linking cancer to haemostasis.
Nature 2005;434(7031):396-400.
2005: Michele De Palma; Eugenio Montini; Francesca Romana Santoni de Sio; Fabrizio Benedicenti; Alessandra Gentile; Enzo Medico; Luigi Naldini
Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells.
Blood 2005;105(6):2307-15.
2005: Carmela Di Domenico; Guglielmo R D Villani; Daniele Di Napoli; Enrico Gonzalez Y Reyero; Angelo Lombardo; Luigi Naldini; Paola Di Natale
Gene therapy for a mucopolysaccharidosis type I murine model with lentiviral-IDUA vector.
Human gene therapy 2005;16(1):81-90.
2005: Mario Amendola; Mary Anna Venneri; Alessandra Biffi; Elisa Vigna; Luigi Naldini
Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters.
Nature biotechnology 2005;23(1):108-16.
2004: Massimiliano Mazzone; Cristina Basilico; Silvia Cavassa; Selma Pennacchietti; Mauro Risio; Luigi Naldini; paolo comoglio; Paolo Michieli
An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice.
The Journal of clinical investigation 2004;114(10):1418-32.
2004: Loic DUPRE; Sara Trifari; Antonia Follenzi; Francesco Marangoni; Teresa Lain de Lera; Antonio Bernad; Silvana Martino; Shigeru Tsuchiya; Claudio Bordignon; Luigi Naldini; Alessandro Aiuti; Maria-Grazia Roncarolo
Lentiviral vector-mediated gene transfer in T cells from Wiskott-Aldrich syndrome patients leads to functional correction.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(5):903-15.
2004: Antonella Consiglio; Angela Gritti; Diego Dolcetta; Antonia Follenzi; Claudio Bordignon; Fred H Gage; Angelo L Vescovi; Luigi Naldini
Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(41):14835-40.
2004: Paolo Michieli; Massimiliano Mazzone; Cristina Basilico; Silvia Cavassa; Antonino Sottile; Luigi Naldini; paolo comoglio
Targeting the tumor and its microenvironment by a dual-function decoy Met receptor.
Cancer cell 2004;6(1):61-73.
2004: Antonia Follenzi; Manuela Battaglia; Angelo Lombardo; Andrea Annoni; Maria-Grazia Roncarolo; Luigi Naldini
Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice.
Blood 2004;103(10):3700-9.
2004: Alessandra Biffi; Michele De Palma; Angelo Quattrini; Ubaldo Del Carro; Stefano Amadio; Ilaria Visigalli; Maria Sessa; Stefania Fasano; Riccardo Brambilla; Sergio Marchesini; Claudio Bordignon; Luigi Naldini
Correction of metachromatic leukodystrophy in the mouse model by transplantation of genetically modified hematopoietic stem cells.
The Journal of clinical investigation 2004;113(8):1118-29.
2003: Tina Ruggiero; Martina Olivero; Antonia Follenzi; Luigi Naldini; Raffaele A Calogero; Maria Flavia Di Renzo
Deletion in a (T)8 microsatellite abrogates expression regulation by 3'-UTR.
Nucleic acids research 2003;31(22):6561-9.
2003: Michele De Palma; Mary Anna Venneri; Luigi Naldini
In vivo targeting of tumor endothelial cells by systemic delivery of lentiviral vectors.
Human gene therapy 2003;14(12):1193-206.
2003: Simona Cavalieri; Sabrina Cazzaniga; Massimo Geuna; Zulma Magnani; Claudio Bordignon; Luigi Naldini; Chiara Bonini
Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence.
Blood 2003;102(2):497-505.
2003: Michele De Palma; Mary Anna Venneri; Cristina Roca; Luigi Naldini
Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells.
Nature medicine 2003;9(6):789-95.
2003: Désirée Bonci; Antonio Cittadini; Michael V G Latronico; Ugo Borello; J K Aycock; Alessandra Drusco; Anna Innocenzi; Antonia Follenzi; Marialuisa Lavitrano; Maria Gaia Monti; J Ross; Luigi Naldini; Cesare Peschle; Giulio Cossu; Gianluigi Condorelli
'Advanced' generation lentiviruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo.
Gene therapy 2003;10(8):630-6.
2003: Wim Janssens; Marinee K L Chuah; Luigi Naldini; Antonia Follenzi; Désiré Collen; Jean-Marie Saint-Remy; Thierry VandenDriessche
Efficiency of onco-retroviral and lentiviral gene transfer into primary mouse and human B-lymphocytes is pseudotype dependent.
Human gene therapy 2003;14(3):263-76.
2002: Wanda Piacibello; Stefania Bruno; Fiorella Sanavio; Sara Droetto; Monica Gunetti; Laurie Ailles; Francesca Romana Santoni de Sio; Andrea Viale; Loretta Gammaitoni; Angelo Lombardo; Luigi Naldini; Massimo Aglietta
Lentiviral gene transfer and ex vivo expansion of human primitive stem cells capable of primary, secondary, and tertiary multilineage repopulation in NOD/SCID mice. Nonobese diabetic/severe combined immunodeficient.
Blood 2002;100(13):4391-400.
2002: Laurie Ailles; Manfred Schmidt; Francesca Romana Santoni de Sio; Hanno Glimm; Simona Cavalieri; Stefania Bruno; Wanda Piacibello; Christof von Kalle; Luigi Naldini
Molecular evidence of lentiviral vector-mediated gene transfer into human self-renewing, multi-potent, long-term NOD/SCID repopulating hematopoietic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):615-26.
2002: Massimiliano Manganini; Marta Serafini; Federica Bambacioni; Chiara Casati; Eugenio Erba; Antonia Follenzi; Luigi Naldini; Sergio Bernasconi; Giuseppe Gaipa; Alessandro Rambaldi; Andrea Biondi; Josée Golay; Martino Introna
A human immunodeficiency virus type 1 pol gene-derived sequence (cPPT/CTS) increases the efficiency of transduction of human nondividing monocytes and T lymphocytes by lentiviral vectors.
Human gene therapy 2002;13(15):1793-807.
2002: Thierry VandenDriessche; Lieven Thorrez; Luigi Naldini; Antonia Follenzi; Lieve Moons; Zwi Berneman; Désiré Collen; Marinee K L Chuah
Lentiviral vectors containing the human immunodeficiency virus type-1 central polypurine tract can efficiently transduce nondividing hepatocytes and antigen-presenting cells in vivo.
Blood 2002;100(3):813-22.
2002: Guglielmo R D Villani; Antonia Follenzi; Borghina Vanacore; Carmela Di Domenico; Luigi Naldini; Paola Di Natale
Correction of mucopolysaccharidosis type IIIb fibroblasts by lentiviral vector-mediated gene transfer.
The Biochemical journal 2002;364(Pt 3):747-53.
2002: Paola Di Natale; Carmela Di Domenico; Guglielmo R D Villani; Angelo Lombardo; Antonia Follenzi; Luigi Naldini
In vitro gene therapy of mucopolysaccharidosis type I by lentiviral vectors.
European journal of biochemistry / FEBS 2002;269(11):2764-71.
2002: Francesco Lotti; Emilio Menguzzato; Claudia Rossi; Luigi Naldini; Laurie Ailles; Fulvio Mavilio; Giuliana Ferrari
Transcriptional targeting of lentiviral vectors by long terminal repeat enhancer replacement.
Journal of virology 2002;76(8):3996-4007.
2002: Elisa Vigna; Simona Cavalieri; Laurie Ailles; Massimo Geuna; Rainer Loew; Hermann Bujard; Luigi Naldini
Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(3):252-61.
2002: Antonia Follenzi; G Sabatino; Angelo Lombardo; Carla Boccaccio; Luigi Naldini
Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors.
Human gene therapy 2002;13(2):243-60.
2002: Antonia Follenzi; Luigi Naldini
HIV-based vectors. Preparation and use.
Methods in molecular medicine 2002;69():259-74.
2002: Laurie Ailles; Luigi Naldini
HIV-1-derived lentiviral vectors.
Current topics in microbiology and immunology 2002;261():31-52.
2002: Thierry VandenDriessche; Luigi Naldini; Désiré Collen; Marinee K L Chuah
Oncoretroviral and lentiviral vector-mediated gene therapy.
Methods in enzymology 2002;346():573-89.
2002: Michele De Palma; Luigi Naldini
Transduction of a gene expression cassette using advanced generation lentiviral vectors.
Methods in enzymology 2002;346():514-29.
2002: Antonia Follenzi; Luigi Naldini
Generation of HIV-1 derived lentiviral vectors.
Methods in enzymology 2002;346():454-65.
2001: Gianluigi Condorelli; Ugo Borello; Luciana De Angelis; Michael V G Latronico; D Sirabella; Marcello Coletta; R Galli; Giovanna Balconi; Antonia Follenzi; Giacomo Frati; Maria Gabriella Cusella De Angelis; L Gioglio; S Amuchastegui; L Adorini; Luigi Naldini; Angelo L Vescovi; Elisabetta Dejana; Giulio Cossu
Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: implications for myocardium regeneration.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10733-8.
2001: D Farson; R Witt; R McGuinness; TJ Dull; M Kelly; J Song; R Radeke; Anatoly A Bukovsky; Antonella Consiglio; Luigi Naldini
A new-generation stable inducible packaging cell line for lentiviral vectors.
Human gene therapy 2001;12(8):981-97.
2001: Antonella Consiglio; Angelo Quattrini; Sabata Martino; J C Bensadoun; Diego Dolcetta; A Trojani; Giuliana Benaglia; Sergio Marchesini; V Cestari; A Oliverio; Claudio Bordignon; Luigi Naldini
In vivo gene therapy of metachromatic leukodystrophy by lentiviral vectors: correction of neuropathology and protection against learning impairments in affected mice.
Nature medicine 2001;7(3):310-6.
2001: Francesco Galimi; E Cottone; Elisa Vigna; Nicolò Arena; Carla Boccaccio; silvia giordano; Luigi Naldini; paolo comoglio
Hepatocyte growth factor is a regulator of monocyte-macrophage function.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1241-7.
2000: Elisa Vigna; Luigi Naldini
Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy.
The journal of gene medicine 2000;2(5):308-16.
2000: Antonia Follenzi; Laurie Ailles; S Bakovic; Massimo Geuna; Luigi Naldini
Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences.
Nature genetics 2000;25(2):217-22.
2000: Luigi Naldini; Inder M Verma
Lentiviral vectors.
Advances in virus research 2000;55():599-609.
1999: Luigi Naldini
In vivo gene delivery by lentiviral vectors.
Thrombosis and haemostasis 1999;82(2):552-4.
1999: A A Bukovsky; J P Song; Luigi Naldini
Interaction of human immunodeficiency virus-derived vectors with wild-type virus in transduced cells.
Journal of virology 1999;73(8):7087-92.
1998: Romain Zufferey; TJ Dull; Ronald J Mandel; Anatoly A Bukovsky; D Quiroz; Luigi Naldini; Didier Trono
Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery.
Journal of virology 1998;72(12):9873-80.
1998: TJ Dull; Romain Zufferey; M Kelly; Ronald J Mandel; M Nguyen; Didier Trono; Luigi Naldini
A third-generation lentivirus vector with a conditional packaging system.
Journal of virology 1998;72(11):8463-71.
1997: Romain Zufferey; Dea Nagy; Ronald J Mandel; Luigi Naldini; Didier Trono
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.
Nature biotechnology 1997;15(9):871-5.
1996: Luigi Naldini; U Blömer; Fred H Gage; Didier Trono; Inder M Verma
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11382-8.
1996: Luigi Naldini; U Blömer; P Gallay; D Ory; R Mulligan; Fred H Gage; Inder M Verma; Didier Trono
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector.
Science (New York, N.Y.) 1996;272(5259):263-7.
1996: U Blömer; Luigi Naldini; Inder M Verma; Didier Trono; Fred H Gage
Applications of gene therapy to the CNS.
Human molecular genetics 1996;5 Spec No():1397-404.