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Ponnal Nambi

Research Profile

Chemicals & Drugs

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John W Ullrich; Robert Morris; Ronald C Bernotas; Jeremy M Travins; James Jetter; Rayomand J Unwalla; Elaine Quinet; Ponnal Nambi; Irene Feingold; Christine Huselton; Christofer Enroth; Anna Wilhelmsson; Annika Goos-Nilsson; Jay Wrobel
Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.
Jeremy M Travins; Ronald C Bernotas; David H Kaufman; Elaine Quinet; Ponnal Nambi; Irene Feingold; Christine Huselton; Anna Wilhelmsson; Annika Goos-Nilsson; Jay Wrobel
1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists.
Robert R Singhaus; Ronald C Bernotas; Robert Steffan; Edward Matelan; Elaine Quinet; Ponnal Nambi; Irene Feingold; Christine Huselton; Anna Wilhelmsson; Annika Goos-Nilsson; Jay Wrobel
3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.

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All Publications

2010: John W Ullrich; Robert Morris; Ronald C Bernotas; Jeremy M Travins; James Jetter; Rayomand J Unwalla; Elaine Quinet; Ponnal Nambi; Irene Feingold; Christine Huselton; Christofer Enroth; Anna Wilhelmsson; Annika Goos-Nilsson; Jay Wrobel
Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.
Bioorganic & medicinal chemistry letters 2010;20(9):2903-7.
2010: Jeremy M Travins; Ronald C Bernotas; David H Kaufman; Elaine Quinet; Ponnal Nambi; Irene Feingold; Christine Huselton; Anna Wilhelmsson; Annika Goos-Nilsson; Jay Wrobel
1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists.
Bioorganic & medicinal chemistry letters 2010;20(2):526-30.
2010: Robert R Singhaus; Ronald C Bernotas; Robert Steffan; Edward Matelan; Elaine Quinet; Ponnal Nambi; Irene Feingold; Christine Huselton; Anna Wilhelmsson; Annika Goos-Nilsson; Jay Wrobel
3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.
Bioorganic & medicinal chemistry letters 2010;20(2):521-5.
2010: Baihua Hu; Ron Bernotas; Rayomand Unwalla; Michael Collini; Elaine Quinet; Irene Feingold; Annika Goos-Nilsson; Anna Wilhelmsson; Ponnal Nambi; Mark Evans; Jay Wrobel
Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration.
Bioorganic & medicinal chemistry letters 2010;20(2):689-93.
2010: Ronald C Bernotas; Robert R Singhaus; David H Kaufman; Jeremy M Travins; John W Ullrich; Rayomand Unwalla; Elaine Quinet; Mark Evans; Ponnal Nambi; Andrea Olland; Björn Kauppi; Anna Wilhelmsson; Annika Goos-Nilsson; Jay Wrobel
4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.
Bioorganic & medicinal chemistry letters 2010;20(1):209-12.
2009: Ronald C Bernotas; David H Kaufman; Robert R Singhaus; John Ullrich; Rayomand Unwalla; Elaine Quinet; Ponnal Nambi; Anna Wilhelmsson; Annika Goos-Nilsson; Jay Wrobel
4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists.
Bioorganic & medicinal chemistry 2009;17(23):8086-92.
2009: Elaine Quinet; Michael D Basso; Anita R Halpern; David W Yates; Robert J Steffan; Valerie Clerin; Christine Resmini; James C Keith; Thomas J Berrodin; Irene Feingold; Wenyan Zhong; Helen B Hartman; Mark J Evans; Stephen J Gardell; Elizabeth DiBlasio-Smith; William M Mounts; Edward R LaVallie; Jay Wrobel; Ponnal Nambi; George P Vlasuk
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse.
Journal of lipid research 2009;50(12):2358-70.
2009: Baihua Hu; Raymound Unwalla; Michael Collini; Elaine Quinet; Irene Feingold; Annika Goos-Nilsson; Anna Wihelmsson; Ponnal Nambi; Jay Wrobel
Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta.
Bioorganic & medicinal chemistry 2009;17(10):3519-27.
2009: Ronald C Bernotas; Robert R Singhaus; David H Kaufman; John Ullrich; Horace Fletcher; Elaine Quinet; Ponnal Nambi; Rayomand J Unwalla; Anna Wilhelmsson; Annika Goos-Nilsson; Mathias Farnegardh; Jay Wrobel
Biarylether amide quinolines as liver X receptor agonists.
Bioorganic & medicinal chemistry 2009;17(4):1663-70.
2008: Jay Wrobel; Robert Steffan; S Marc Bowen; Ronald Magolda; Edward Matelan; Rayomand Unwalla; Michael Basso; Valerie Clerin; Stephen J Gardell; Ponnal Nambi; Elaine Quinet; Jason I Reminick; George P Vlasuk; Shuguang Wang; Irene Feingold; Christine Huselton; Tomas Bonn; Mathias Farnegardh; Tomas Hansson; Annika Goos Nilsson; Anna Wilhelmsson; Edouard Zamaratski; Mark J Evans
Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.
Journal of medicinal chemistry 2008;51(22):7161-8.
2008: Elizabeth A DiBlasio-Smith; Maya Arai; Elaine Quinet; Mark J Evans; Tad Kornaga; Michael D Basso; Liang Chen; Irene Feingold; Anita R Halpern; Qiang-Yuan Liu; Ponnal Nambi; Dawn Savio; Shuguang Wang; William M Mounts; Jennifer A Isler; Anna M Slager; Michael Burczynski; Andrew J Dorner; Edward R LaVallie
Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells.
Journal of translational medicine 2008;6():59.
2008: Baihua Hu; Elaine Quinet; Rayomand J Unwalla; Mike Collini; James Jetter; Rebecca Dooley; Diane Andraka; Lisa M Nogle; Dawn A Savio; Anita Halpern; Annika Goos-Nilsson; Anna Wilhelmsson; Ponnal Nambi; Jay Wrobel
Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.
Bioorganic & medicinal chemistry letters 2008;18(1):54-9.
2007: Qiang-Yuan Liu; Elaine Quinet; Ponnal Nambi
Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells.
Molecular and cellular biochemistry 2007;302(1-2):203-13.
2007: Courtney E Leik; N L Carson; James K Hennan; Mike D Basso; Q-Y Liu; David L Crandall; Ponnal Nambi
GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats.
British journal of pharmacology 2007;151(4):450-6.
2007: Baihua Hu; James Jetter; David Kaufman; Robert Singhaus; Ronald C Bernotas; Rayomand J Unwalla; Elaine Quinet; Dawn A Savio; Anita Halpern; Michael Basso; James Carl Keith; Valerie Clerin; Liang Chen; Qiang-Yuan Liu; Irene Feingold; Christine Huselton; Farooq Azam; Annika Goos-Nilsson; Anna Wilhelmsson; Ponnal Nambi; Jay Wrobel
Further modification on phenyl acetic acid based quinolines as liver X receptor modulators.
Bioorganic & medicinal chemistry 2007;15(10):3321-33.
2006: Courtney E Leik; Enming Joseph Su; Ponnal Nambi; David L Crandall; Daniel Lawrence
Effect of pharmacologic plasminogen activator inhibitor-1 inhibition on cell motility and tumor angiogenesis.
Journal of thrombosis and haemostasis : JTH 2006;4(12):2710-5.
2006: Baihua Hu; Michael Collini; Rayomand J Unwalla; Christopher Miller; Robert Singhaus; Elaine Quinet; Dawn A Savio; Anita Halpern; Michael Basso; James Carl Keith; Valerie Clerin; Liang Chen; Christine Resmini; Qiang-Yuan Liu; Irene Feingold; Christine Huselton; Farooq Azam; Mathias Farnegardh; Cristofer Enroth; Tomas Bonn; Annika Goos-Nilsson; Anna Wilhelmsson; Ponnal Nambi; Jay Wrobel
Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis.
Journal of medicinal chemistry 2006;49(21):6151-4.
2006: Elaine Quinet; Dawn A Savio; Anita R Halpern; Liang Chen; Gertrude U Schuster; Jan-�ke GUSTAFSSON; Mike D Basso; Ponnal Nambi
Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting.
Molecular pharmacology 2006;70(4):1340-9.
2006: Qiang-Yuan Liu; Martha Corjay; Giora Z Feuerstein; Ponnal Nambi
Identification and characterization of triosephosphate isomerase that specifically interacts with the integrin alphaIIb cytoplasmic domain.
Biochemical pharmacology 2006;72(5):551-7.
2004: Q-Y Liu; Ponnal Nambi
Sirolimus upregulates aP2 expression in human monocytes and macrophages.
Transplantation proceedings 2004;36(10):3229-31.
2004: Elaine Quinet; Dawn A Savio; Anita R Halpern; Liang Chen; Christopher P Miller; Ponnal Nambi
Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor.
Journal of lipid research 2004;45(10):1929-42.
2004: Narayanan Parameswaran; William S Spielman; David P Brooks; Ponnal Nambi
Okadaic acid stimulates caspase-like activities and induces apoptosis of cultured rat mesangial cells.
Molecular and cellular biochemistry 2004;260(1-2):7-11.
2003: Mike D Basso; Ponnal Nambi; Steven J Adelman
Effect of sirolimus on the cholesterol content of aortic arch in ApoE knockout mice.
Transplantation proceedings 2003;35(8):3136-8.
2003: Ponnal Nambi; Nambi Aiyar
G protein-coupled receptors in drug discovery.
Assay and drug development technologies 2003;1(2):305-10.
2002: Nambi Aiyar; Jyoti Disa; Zhaohui Ao; Dong Xu; Arjun Surya; Kodandaram Pillarisetti; Narayanan Parameswaran; Shalley K Gupta; Stephen Douglas; Ponnal Nambi
Molecular cloning and pharmacological characterization of bovine calcitonin receptor-like receptor from bovine aortic endothelial cells.
Biochemical pharmacology 2002;63(11):1949-59.
2001: Nambi Aiyar; Jyoti Disa; Mark A Pullen; Ponnal Nambi
Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells.
Molecular and cellular biochemistry 2001;224(1-2):123-33.
2001: Mark A Pullen; K Thomas; H Wu; Ponnal Nambi
Stimulation of Hyaluronan synthetase by platelet-derived growth factor bb in human prostate smooth muscle cells.
Pharmacology 2001;62(2):103-6.
2000: Narayanan Parameswaran; Nambi Aiyar; H Wu; David P Brooks; Ponnal Nambi; William S Spielman
Desensitization and resensitization of adrenomedullin-sensitive receptor in rat mesangial cells.
European journal of pharmacology 2000;407(3):205-10.
2000: Don E Griswold; Stephen Douglas; Lenox D Martin; T G Davis; L Davis; Zhaohui Ao; Mark A Luttmann; Mark A Pullen; Ponnal Nambi; Douglas W P Hay; Eliot ohlstein
Targeted disruption of the endothelin-B-receptor gene attenuates inflammatory nociception and cutaneous inflammation in mice.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S78-81.
2000: Nambi Aiyar; Jyoti Disa; K Dang; A N Pronin; J L Benovic; Ponnal Nambi
Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors.
European journal of pharmacology 2000;403(1-2):1-7.
2000: CS Louden; Ponnal Nambi; Mark A Pullen; R A Thomas; L A Tierney; HA Solleveld; Lester W Schwartz
Endothelin receptor subtype distribution predisposes coronary arteries to damage.
The American journal of pathology 2000;157(1):123-34.
2000: Jyoti Disa; Narayanan Parameswaran; Ponnal Nambi; Nambi Aiyar
Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line.
Neuropeptides 2000;34(3-4):229-33.
2000: David P Brooks; Ponnal Nambi; Nicholas J Laping; Barbara A Olson; Mark A Pullen; C E Wade
Renal vasopressin receptor expression and function in rats following spaceflight.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(4):1316-20.
2000: Narayanan Parameswaran; Jyoti Disa; William S Spielman; David P Brooks; Ponnal Nambi; Nambi Aiyar
Activation of multiple mitogen-activated protein kinases by recombinant calcitonin gene-related peptide receptor.
European journal of pharmacology 2000;389(2-3):125-30.
2000: Narayanan Parameswaran; Ponnal Nambi; Carolyn S Hall; David P Brooks; William S Spielman
Adrenomedullin decreases extracellular signal-regulated kinase activity through an increase in protein phosphatase-2A activity in mesangial cells.
European journal of pharmacology 2000;388(2):133-8.
2000: Ponnal Nambi; HL Wu; D Ye; A Gagnon; N Elshourbagy
Characterization of a novel porcine endothelin(B) receptor splice variant.
The Journal of pharmacology and experimental therapeutics 2000;292(1):247-53.
1999: SM Ali; Ponnal Nambi; TA Fredrickson; David P Brooks
Epithelin mRNA expression in polycystic kidney disease.
Peptides 1999;20(12):1489-95.
1999: Don E Griswold; Stephen Douglas; Lenox D Martin; T G Davis; L Davis; Zhaohui Ao; Mark A Luttmann; Mark A Pullen; Ponnal Nambi; Douglas W P Hay; Eliot ohlstein
Endothelin B receptor modulates inflammatory pain and cutaneous inflammation.
Molecular pharmacology 1999;56(4):807-12.
1999: Ponnal Nambi; Mark A Pullen; HL Wu; U Prabhakar; Louis B Hersh; M Gellai
Down regulation of kidney neutral endopeptidase mRNA, protein and activity during acute renal failure: possible mechanism for ischemia-induced acute renal failure in rats?
Molecular and cellular biochemistry 1999;197(1-2):53-9.
1999: Richard M Edwards; Mark A Pullen; Ponnal Nambi
Distribution of neutral endopeptidase activity along the rat and rabbit nephron.
Pharmacology 1999;59(1):45-50.
1999: Narayanan Parameswaran; Ponnal Nambi; David P Brooks; William S Spielman
Regulation of glomerular mesangial cell proliferation in culture by adrenomedullin.
European journal of pharmacology 1999;372(1):85-95.
1999: Narayanan Parameswaran; William S Spielman; David P Brooks; Ponnal Nambi
SB203580 reverses adrenomedullin's effect on proliferation and apoptosis in cultured mesangial cells.
European journal of pharmacology 1999;371(1):75-82.
1999: Narayanan Parameswaran; William S Spielman; Mark A Pullen; J Francis; David P Brooks; Ponnal Nambi
Mechanism of adrenomedullin-stimulated hyaluronic acid release in rat mesangial cells.
European journal of pharmacology 1999;370(3):313-8.
1999: HL Wu; CR Albrightson; Ponnal Nambi
Selective inhibition of rat mesangial cell proliferation by a synthetic peptide derived from the sequence of the C2 region of PKCbeta.
Peptides 1999;20(6):675-8.
1998: Eliot ohlstein; Ponnal Nambi; Douglas W P Hay; M Gellai; David P Brooks; JI Luengo; Jia-Ning Xiang; John D Elliott
Nonpeptide endothelin receptor antagonists. XI. Pharmacological characterization of SB 234551, a high-affinity and selective nonpeptide ETA receptor antagonist.
The Journal of pharmacology and experimental therapeutics 1998;286(2):650-6.
1998: H L Wu; Ponnal Nambi
Transforming growth factor-beta-mediated proliferation of renal tubular epithelial cells involves pertussis toxin-sensitive G protein-and protein kinase C-dependent pathways.
Pharmacology 1998;57(1):8-12.
1998: Jia-Ning Xiang; Ponnal Nambi; Eliot ohlstein; John D Elliott
An efficient approach to the synthesis of 1,3-diaryl-1,2,3,4-[4H]-tetrahydronaphthalene-2-carboxylic acids.
Bioorganic & medicinal chemistry 1998;6(6):695-700.
1998: Douglas W P Hay; Mark A Luttmann; Mark A Pullen; Ponnal Nambi
Functional and binding characterization of endothelin receptors in human bronchus: evidence for a novel endothelin B receptor subtype?
The Journal of pharmacology and experimental therapeutics 1998;284(2):669-77.
1998: Nicholas J Laping; Barbara A Olson; R E DeWolf; CR Albrightson; TA Fredrickson; C King; M Chirivella; Fuad N Ziyadeh; Ponnal Nambi
Activation of glomerular mesangial cells by hepatocyte growth factor through tyrosine kinase and protein kinase C.
Biochemical pharmacology 1998;55(2):227-34.
1998: CS Louden; Ponnal Nambi; C Branch; K Gossett; Mark A Pullen; S Eustis; HA Solleveld
Coronary arterial lesions in dogs treated with an endothelin receptor antagonist.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S384-5.
1998: David P Brooks; PD Depalma; Mark A Pullen; John D Elliott; Eliot ohlstein; Ponnal Nambi
SB 234551, a novel endothelin--A receptor antagonist, unmasks endothelin-induced renal vasodilatation in the dog.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S339-41.
1998: Robert N Willette; H Minehart; J Ellison; T Simons; B Short; Mark A Pullen; Eliot ohlstein; Ponnal Nambi
Effects of endothelin receptor antagonism and angiotensin-converting enzyme inhibition on cardiac and renal remodeling in the rat.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S277-83.
1998: Stephen Douglas; Ponnal Nambi; M Gellai; JI Luengo; Jia-Ning Xiang; David P Brooks; RR Ruffolo; John D Elliott; Eliot ohlstein
Pharmacologic characterization of the novel, orally available endothelin-A--selective antagonist SB 247083.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S273-6.
1997: Ponnal Nambi; M Gellai; HL Wu; U Prabhakar
Upregulation of osteopontin in ischemia-induced renal failure in rats: a role for ET-1?
Biochemical and biophysical research communications 1997;241(1):212-4.
1997: M Gellai; R De Wolf; T Fletcher; Ponnal Nambi
Contribution of endogenous endothelin-1 to the maintenance of vascular tone: role of nitric oxide.
Pharmacology 1997;55(6):299-308.
1997: Ponnal Nambi; Mark A Pullen; J Kincaid; P Nuthulaganti; Nambi Aiyar; David P Brooks; M Gellai; C Kumar
Identification and characterization of a novel endothelin receptor that binds both ETA- and ETB-selective ligands.
Molecular pharmacology 1997;52(4):582-9.
1997: Ponnal Nambi; Michael R Mattern; HL Wu; Mark A Pullen; P Nuthulaganti; Glenn Hofmann; C Kumar
Absence of endothelin receptors and receptor mRNA in mammalian fibroblasts transformed with SV40 or ras oncogene.
Molecular and cellular biochemistry 1997;175(1-2):29-35.
1997: Mark A Pullen; G Brown; Ponnal Nambi
Binding characteristics of [125I]TTA 386, ETA-selective antagonist.
Neuropeptides 1997;31(4):345-9.
1997: Nambi Aiyar; Jyoti Disa; I R Siemens; Ponnal Nambi
Differential effects of guanine nucleotides on [125I]-hCGRP(8-37) binding to porcine lung and human neuroblastoma cell membranes.
Neuropeptides 1997;31(1):99-103.
1996: Nabil A Elshourbagy; John E Adamou; A W Gagnon; HL Wu; Mark A Pullen; Ponnal Nambi
Molecular characterization of a novel human endothelin receptor splice variant.
The Journal of biological chemistry 1996;271(41):25300-7.
1996: M Gellai; T Fletcher; Mark A Pullen; Ponnal Nambi
Evidence for the existence of endothelin-B receptor subtypes and their physiological roles in the rat.
The American journal of physiology 1996;271(1 Pt 2):R254-61.
1996: Ponnal Nambi; Mark A Pullen; HL Wu; D Lee; D Saunders; R Heys; Nambi Aiyar; J Leber; J Elliott; D Brooks; Eliot ohlstein; RR Ruffolo
Nonpeptide endothelin receptor antagonists. VII: Binding characteristics of [3H]SB 209670, a novel nonpeptide antagonist of endothelin receptors.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1567-71.
1996: Ponnal Nambi
Endothelin receptors in normal and diseased kidneys.
Clinical and experimental pharmacology & physiology 1996;23(4):326-30.
1996: Ponnal Nambi; Mark A Pullen; Nambi Aiyar
Correlation between guanine nucleotide effect and reversible binding property of endothelin analogs.
Neuropeptides 1996;30(1):109-14.
1996: Eliot ohlstein; Ponnal Nambi; A Lago; Douglas W P Hay; G Beck; K L Fong; E P Eddy; P Smith; H Ellens; John D Elliott
Nonpeptide endothelin receptor antagonists. VI: Pharmacological characterization of SB 217242, a potent and highly bioavailable endothelin receptor antagonist.
The Journal of pharmacology and experimental therapeutics 1996;276(2):609-15.
1995: Ponnal Nambi; Mark A Pullen; David P Brooks; M Gellai
Identification of ETB receptor subtypes using linear and truncated analogs of ET.
Neuropeptides 1995;29(6):331-6.
1995: M Gellai; M Jugus; T Fletcher; Ponnal Nambi; Eliot ohlstein; John D Elliott; David P Brooks
Nonpeptide endothelin receptor antagonists. V: Prevention and reversal of acute renal failure in the rat by SB 209670.
The Journal of pharmacology and experimental therapeutics 1995;275(1):200-6.
1995: PG Lysko; Nabil A Elshourbagy; Mark A Pullen; Ponnal Nambi
Developmental expression of endothelin receptors in cerebellar neurons differentiating in culture.
Brain research. Developmental brain research 1995;88(1):96-101.
1995: CR Albrightson; Mark A Pullen; HL Wu; GM Dytko; Louis B Hersh; Ponnal Nambi
Thrombin-mediated down-regulation of endothelin receptors in mesangial cells coincides with the down-regulation of neutral endopeptidase activity.
Molecular pharmacology 1995;47(6):1156-63.
1995: Ponnal Nambi; Mark A Pullen
[125I]-BQ3020, a potent ETB-selective agonist, displays species differences in its binding characteristics.
Neuropeptides 1995;28(3):191-6.
1995: Ponnal Nambi; HL Wu; D Lipshutz; U Prabhakar
Identification and characterization of endothelin receptors on rat osteoblastic osteosarcoma cells: down-regulation by 1,25-dihydroxy-vitamin D3.
Molecular pharmacology 1995;47(2):266-71.
1995: David P Brooks; P D DePalma; Mark A Pullen; M Gellai; Ponnal Nambi
Identification and function of putative ETB receptor subtypes in the dog kidney.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S322-5.
1994: David P Brooks; P D dePalma; M Gellai; Ponnal Nambi; Eliot ohlstein; John D Elliott; J G Gleason; RR Ruffolo
Nonpeptide endothelin receptor antagonists. III. Effect of SB 209670 and BQ123 on acute renal failure in anesthetized dogs.
The Journal of pharmacology and experimental therapeutics 1994;271(2):769-75.
1994: Eliot ohlstein; G R Beck; Stephen Douglas; Ponnal Nambi; MA Lago; J G Gleason; RR Ruffolo; Giora Feuerstein; John D Elliott
Nonpeptide endothelin receptor antagonists. II. Pharmacological characterization of SB 209670.
The Journal of pharmacology and experimental therapeutics 1994;271(2):762-8.
1994: Ponnal Nambi; Nabil A Elshourbagy; HL Wu; Mark A Pullen; Eliot ohlstein; David P Brooks; MA Lago; John D Elliott; J G Gleason; RR Ruffolo
Nonpeptide endothelin receptor antagonists. I. Effects on binding and signal transduction on human endothelinA and endothelinB receptors.
The Journal of pharmacology and experimental therapeutics 1994;271(2):755-61.
1994: M Gellai; R DeWolf; Mark A Pullen; Ponnal Nambi
Distribution and functional role of renal ET receptor subtypes in normotensive and hypertensive rats.
Kidney international 1994;46(5):1287-94.
1994: Eliot ohlstein; Ponnal Nambi; Stephen Douglas; R M Edwards; M Gellai; A Lago; J D Leber; Russell D Cousins; A Gao; J S Frazee
SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):8052-6.
1994: John D Elliott; MA Lago; Russell D Cousins; A Gao; J D Leber; Karl F Erhard; Ponnal Nambi; Nabil A Elshourbagy; C Kumar; J A Lee
1,3-Diarylindan-2-carboxylic acids, potent and selective non-peptide endothelin receptor antagonists.
Journal of medicinal chemistry 1994;37(11):1553-7.
1994: C Kumar; V Mwangi; Parvathi Nuthulaganti; HL Wu; Mark A Pullen; K Brun; H Aiyar; R A Morris; R Naughton; Ponnal Nambi
Cloning and characterization of a novel endothelin receptor from Xenopus heart.
The Journal of biological chemistry 1994;269(18):13414-20.
1994: Nambi Aiyar; E Baker; Ponnal Nambi; Giora Feuerstein; Robert N Willette
Characterization of CGRP receptors in various regions of gerbil brain.
Neuropeptides 1994;26(5):313-7.
1994: Nambi Aiyar; E Baker; Mark A Pullen; Parvathi Nuthulaganti; DJ Bergsma; C Kumar; Ponnal Nambi
Characterization of a functional angiotensin II receptor in Xenopus laevis heart.
Pharmacology 1994;48(4):242-9.
1994: Ponnal Nambi; Mark A Pullen; C Kumar
Identification of a novel endothelin receptor in Xenopus laevis liver.
Neuropeptides 1994;26(3):181-5.
1994: Ponnal Nambi; Mark A Pullen; M J Slivjak; Eliot ohlstein; B Storer; E F Smith
Endotoxin-mediated changes in plasma endothelin concentrations, renal endothelin receptor and renal function.
Pharmacology 1994;48(3):147-56.
1994: David P Brooks; P D DePalma; Mark A Pullen; Ponnal Nambi
Characterization of canine renal endothelin receptor subtypes and their function.
The Journal of pharmacology and experimental therapeutics 1994;268(3):1091-7.
1994: Nambi Aiyar; E Baker; H L Wu; Ponnal Nambi; R M Edwards; J J Trill; C Ellis; DJ Bergsma
Human AT1 receptor is a single copy gene: characterization in a stable cell line.
Molecular and cellular biochemistry 1994;131(1):75-86.
1994: M Gellai; M Jugus; T Fletcher; R DeWolf; Ponnal Nambi
Reversal of postischemic acute renal failure with a selective endothelinA receptor antagonist in the rat.
The Journal of clinical investigation 1994;93(2):900-6.
1994: Ponnal Nambi; Mark A Pullen; William S Spielman
Species differences in the binding characteristics of [125I]IRL-1620, a potent agonist specific for endothelin-B receptors.
The Journal of pharmacology and experimental therapeutics 1994;268(1):202-7.
1993: Y X Wang; Richard M Edwards; Ponnal Nambi; EJ Stack; Mark A Pullen; L Share; J T Crofton; David P Brooks
Sex difference in the antidiuretic activity of vasopressin in the rat.
The American journal of physiology 1993;265(6 Pt 2):R1284-90.
1993: Richard M Edwards; EJ Stack; Mark A Pullen; Ponnal Nambi
Endothelin inhibits vasopressin action in rat inner medullary collecting duct via the ETB receptor.
The Journal of pharmacology and experimental therapeutics 1993;267(3):1028-33.
1993: DJ Bergsma; C Ellis; Parvathi Nuthulaganti; Ponnal Nambi; K Scaife; C Kumar; Nambi Aiyar
Isolation and expression of a novel angiotensin II receptor from Xenopus laevis heart.
Molecular pharmacology 1993;44(2):277-84.
1993: C S Kumar; Parvathi Nuthulaganti; Mark A Pullen; Ponnal Nambi
Novel endothelin receptors in the follicular membranes of Xenopus laevis oocytes mediate calcium responses by signal transduction through gap junctions.
Molecular pharmacology 1993;44(1):153-7.
1993: Nabil A Elshourbagy; D R Korman; HL Wu; D R Sylvester; J A Lee; P Nuthalaganti; DJ Bergsma; C S Kumar; Ponnal Nambi
Molecular characterization and regulation of the human endothelin receptors.
The Journal of biological chemistry 1993;268(6):3873-9.
1993: U Prabhakar; D Lipshutz; Mark A Pullen; H Turchin; S Kassis; Ponnal Nambi
Protein kinase C regulates TNF-alpha production by human monocytes.
European cytokine network 1993;4(1):31-7.
1993: Nambi Aiyar; E Griffin; R Edwards; J Weinstock; James Samanen; Ponnal Nambi
Characterization of bovine ovary angiotensin II receptors using subtype-selective antagonists.
Pharmacology 1993;46(1):1-8.
1993: Ponnal Nambi; Mark A Pullen; M Jugus; M Gellai
Rat kidney endothelin receptors in ischemia-induced acute renal failure.
The Journal of pharmacology and experimental therapeutics 1993;264(1):345-8.
1993: Robert N Willette; Eliot ohlstein; Mark A Pullen; Charles F Sauermelch; A Cohen; Ponnal Nambi
Transient forebrain ischemia alters acutely endothelin receptor density and immunoreactivity in gerbil brain.
Life sciences 1993;52(1):35-40.
1992: Richard M Edwards; Mark A Pullen; Ponnal Nambi
Activation of endothelin ETB receptors increases glomerular cGMP via an L-arginine-dependent pathway.
The American journal of physiology 1992;263(6 Pt 2):F1020-5.
1992: CR Albrightson; Ponnal Nambi; B Zabko-Potapovich; GM Dytko; T Groom
Effect of thrombin on proliferation, contraction and prostaglandin production of rat glomerular mesangial cells in culture.
The Journal of pharmacology and experimental therapeutics 1992;263(1):404-12.
1992: Ponnal Nambi; Mark A Pullen; HL Wu; Parvathi Nuthulaganti; Nabil A Elshourbagy; C Kumar
Dexamethasone down-regulates the expression of endothelin receptors in vascular smooth muscle cells.
The Journal of biological chemistry 1992;267(27):19555-9.
1992: Ponnal Nambi; Mark A Pullen; HL Wu; Nambi Aiyar; Eliot ohlstein; Richard M Edwards
Identification of endothelin receptor subtypes in human renal cortex and medulla using subtype-selective ligands.
Endocrinology 1992;131(3):1081-6.
1992: Ponnal Nambi; HL Wu; Mark A Pullen; Nambi Aiyar; H Bryan; J Elliott
Identification of endothelin receptor subtypes in rat kidney cortex using subtype-selective ligands.
Molecular pharmacology 1992;42(2):336-9.
1992: Nambi Aiyar; E Griffin; C Albrightson-Winslow; Giora Feuerstein; Ponnal Nambi
Homologous desensitization of calcitonin gene-related peptide response in rat glomerular mesangial cells in culture.
Molecular and cellular biochemistry 1992;113(1):17-23.
1992: Nambi Aiyar; Michael R Mattern; Glenn Hofmann; Richard M Edwards; Ponnal Nambi
Down-regulation of CGRP-mediated cAMP accumulation in ras-transformed 3T3 fibroblasts.
Annals of the New York Academy of Sciences 1992;657():449-51.
1991: M M Gleason; E C Griffin; Ponnal Nambi; Nambi Aiyar
Endothelin stimulates 86Rb efflux in rat glioma C6-Bu-1 cells.
Neuropeptides 1991;20(1):17-23.
1991: Nambi Aiyar; Ponnal Nambi; E Griffin; P Bhatnagar; Giora Feuerstein
Identification and characterization of calcitonin gene-related peptide receptors in porcine renal medullary membranes.
Endocrinology 1991;129(2):965-9.
1991: M M Gleason; HL Wu; Tian-Li Yue; Giora Feuerstein; Ponnal Nambi
Comparison of endothelin binding and calcium mobilization in C6-BU-1 rat glioma and N18TG2 mouse neuroblastoma cells.
Neuropeptides 1991;19(3):197-204.
1991: Ponnal Nambi; Mark A Pullen; H L Wu; David P Brooks
Increase in renal phorbol ester receptors in rats with cyclosporine A-induced nephrotoxicity.
European journal of pharmacology 1991;195(1):167-9.
1991: A G DiLella; E Ohlstein; Nabil A Elshourbagy; P K Bhatnagar; Ponnal Nambi; W E DeWolf; M M Caltabiano
Expression of human preproendothelin-1 cDNA in COS cells results in the production of mature vasoactive endothelin-1.
Biochemical and biophysical research communications 1991;175(2):697-705.
1991: David P Brooks; Eliot ohlstein; L C Contino; B Storer; Mark A Pullen; M Caltabiano; Ponnal Nambi
Effect of nifedipine on cyclosporine A-induced nephrotoxicity, urinary endothelin excretion and renal endothelin receptor number.
European journal of pharmacology 1991;194(1):115-7.
1991: C R Albrightson-Winslow; B Brickson; David P Brooks; W M Bryan; N Caldwell; L B Kinter; M L Moore; Ponnal Nambi; F L Stassen; William F Huffman
Vasopressin antidiuretic agonist and antagonist activity in dogs: structural and stereochemical relationship between bridge and carboxyl terminus.
The Journal of pharmacology and experimental therapeutics 1991;256(1):335-40.
1991: Ponnal Nambi; Mark A Pullen; J W Egan; E F Smith
Identification of cardiac endothelin binding sites in rats: downregulation of left atrial endothelin binding sites in response to myocardial infarction.
Pharmacology 1991;43(2):84-9.
1991: Tian-Li Yue; Ponnal Nambi; HL Wu; Giora Feuerstein
Endothelin receptor binding and cellular signal transduction in neurohybrid NG108-15 cells.
Neuroscience 1991;44(1):215-22.
1990: Ponnal Nambi; HL Wu; R D Woessner; Michael R Mattern
Inhibition of endothelin-mediated topoisomerase I activation by pertussis toxin.
FEBS letters 1990;276(1-2):17-20.
1990: Ponnal Nambi; Mark A Pullen; L C Contino; David P Brooks
Upregulation of renal endothelin receptors in rats with cyclosporine A-induced nephrotoxicity.
European journal of pharmacology 1990;187(1):113-6.
1990: Eliot ohlstein; B Storer; Ponnal Nambi; Michael B Given; Howard Lippton
Endothelin and platelet function.
Thrombosis research 1990;57(6):967-74.
1990: Ponnal Nambi; Nambi Aiyar; HL Wu; S T Crooke
Possible involvement of protein kinase C and cyclic AMP-dependent protein kinase in the sodium fluoride-mediated inhibition of cyclic nucleotide accumulation in smooth muscle cells.
Cellular signalling 1990;2(6):531-6.