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Tomoki Naoe

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Takahiko Yasuda; Yoshiko Atsuta; Nobuhiko Emi; Yoshihiro Inamoto; Yuichi Ishikawa; Hirokazu Nagai; Yukiyasu Ozawa; Kazutaka Ozeki; Ritsuro Suzuki; Seitaro Terakura; Masamitsu Yanada; Tomoki Naoe
Randomized controlled trial comparing ciprofloxacin and cefepime in febrile neutropenic patients with hematological malignancies.
N Mizutani; Yoshiko Banno; S Fujii; M Ichihara; Hidenori Ito; Y Ito; S Iwaki; M Kobayashi; Tetsuhito Kojima; Mitsuhiro Nakamura; Tomoki Naoe; Yoshinori Nozawa; Sayaka Sobue; Motoshi Suzuki; Akira Takagi; Keiko Tamiya-Koizumi; Kouji Tanaka; Takashi Murate
Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB.
Masahito Kawazu; Kenji Kontani; Mizuo Ando; Young Lim Choi; Kazutaka Fukumura; Toshiaki Katada; Yoshio Miki; Tomoki Naoe; Yoshitaka Ogita; Manabu Soda; Kengo Takeuchi; Toshihide Ueno; Hiroyuki Yamaguchi; Yoshihiro Yamashita; Azusa Yamato; Takahiko Yasuda; Hiroyuki Mano
Transforming mutations of RAC guanosine triphosphatases in human cancers.

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2013: Takahiko Yasuda; Yoshiko Atsuta; Nobuhiko Emi; Yoshihiro Inamoto; Yuichi Ishikawa; Hirokazu Nagai; Yukiyasu Ozawa; Kazutaka Ozeki; Ritsuro Suzuki; Seitaro Terakura; Masamitsu Yanada; Tomoki Naoe
Randomized controlled trial comparing ciprofloxacin and cefepime in febrile neutropenic patients with hematological malignancies.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2013;17(6):e385-90.
2013: N Mizutani; Yoshiko Banno; S Fujii; M Ichihara; Hidenori Ito; Y Ito; S Iwaki; M Kobayashi; Tetsuhito Kojima; Mitsuhiro Nakamura; Tomoki Naoe; Yoshinori Nozawa; Sayaka Sobue; Motoshi Suzuki; Akira Takagi; Keiko Tamiya-Koizumi; Kouji Tanaka; Takashi Murate
Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB.
Biochimica et biophysica acta 2013;1833(5):1006-16.
2013: Masahito Kawazu; Kenji Kontani; Mizuo Ando; Young Lim Choi; Kazutaka Fukumura; Toshiaki Katada; Yoshio Miki; Tomoki Naoe; Yoshitaka Ogita; Manabu Soda; Kengo Takeuchi; Toshihide Ueno; Hiroyuki Yamaguchi; Yoshihiro Yamashita; Azusa Yamato; Takahiko Yasuda; Hiroyuki Mano
Transforming mutations of RAC guanosine triphosphatases in human cancers.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):3029-34.
2013: Tomoki Naoe; Hitoshi Kiyoi
Gene mutations of acute myeloid leukemia in the genome era.
International journal of hematology 2013;97(2):165-74.
2012: Akihiro Abe; Tadaharu Kanie; Akira Katsumi; Miki Kobayashi; Tomoki Naoe; Akinao Okamoto; Masutaka Tokuda; Yukiya Yamamoto; Nobuhiko Emi
A novel RUNX1-C11orf41 fusion gene in a case of acute myeloid leukemia with a t(11;21)(p14;q22).
Cancer genetics 2012;205(11):608-11.
2012: H Mizuno; N Nakao; T Nakayama; S Nishiwaki; S Saito; K Takeshita; Y Miyata; Tomoki Naoe
Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib.
Leukemia 2012;26(10):2269-76.
2012: Tomoki Naoe
[109th Scientific Meeting of the Japanese Society of Internal Medicine: invited lecture: 5. Molecular target therapy for leukemia].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2012;101(9):2497-504.
2012: Satoshi Nishiwaki; Takenori Ozaki; Shigeki Saito; Yoshiyuki Takahashi; Seiji Kojima; Shoichi Maruyama; Hiroki Mizuno; Makoto Murata; Takayuki Nakayama; T Nishida; Tomoki Naoe
Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis.
International journal of hematology 2012;96(3):295-300.
2012: Yachiyo Kuwatsuka; Koichi Miyamura; Yoshihisa Morishita; Makoto Murata; Koji Nagafuji; Tomoki Naoe; Shigeki Saito; Masashi Sawa; Kazuyuki Shimada; Ritsuro Suzuki; Shuichi Taniguchi; Seitaro Terakura; Takahiko Yasuda; Yoshiko Atsuta; Mariko Fukumoto; Yoshihiro Inamoto; Takahiro Karasuno; Akio Kohno
Phase II study of dose-modified busulfan by real-time targeting in allogeneic hematopoietic stem cell transplantation for myeloid malignancy.
Cancer science 2012;103(9):1688-94.
2012: Y Minami; K Miyamura; S Mizuno; Akihiro Abe; Junji Hiraga; Y Inagaki; K Kitamura; M Minami; M Sawa; K Ymamoto; Tomoki Naoe
Retention of CD34+ CML stem/progenitor cells during imatinib treatment and rapid decline after treatment with second-generation BCR-ABL inhibitors.
Leukemia 2012;26(9):2142-3.
2012: Tomoki Naoe
Guest editorial: introducing progress in hematology in this issue.
International journal of hematology 2012;96(2):151-2.
2012: Masamitsu Yanada; Tomoki Naoe
Acute myeloid leukemia in older adults.
International journal of hematology 2012;96(2):186-93.
2012: Takumi Sugimoto; Akihiro Tomita; Akihiro Abe; Chisako Iriyama; Hitoshi Kiyoi; Tomoki Naoe
Chimeric antisense RNA derived from chromosomal translocation modulates target gene expression.
Haematologica 2012;97(8):1278-80.
2012: Akihiro Tomita; Hisashi Tsurumi; Takahiko Ito; Yukari Shirasugi; Tomoki Naoe
Extravascular hemolytic attack after eculizumab therapy for paroxysmal nocturnal hemoglobinuria.
Annals of hematology 2012;91(7):1139-41.
2012: Yuhri Miyawaki; Moe Murata; Takashi Murate; Tomoki Naoe; Kohji Okamoto; Eriko Okuyama; Hidehiko Saito; Michio Sakai; Atsuo Suzuki; Akira Takagi; Junko Fujita; Shinji Kunishima; Asuka Maki; Tadashi Matsushita; Tetsuhito Kojima
Thrombosis from a prothrombin mutation conveying antithrombin resistance.
The New England journal of medicine 2012;366(25):2390-6.
2012: Takahiko Yasuda; Keiki Sugimoto; Akihiro Tomita; Fumihiko Hayakawa; Shingo Kurahashi; Yosuke Minami; Tomoki Naoe
B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):6127-34.
2012: Keisuke Watanabe; Yukiyasu Ozawa; Yosuke Minami; Koichi Miyamura; Tomoki Naoe
T315I mutation in Ph-positive acute lymphoblastic leukemia is associated with a highly aggressive disease phenotype: three case reports.
Anticancer research 2012;32(5):1779-83.
2012: Shingo Kurahashi; Tomoki Naoe
[Classification of acute myeloid leukemia].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 2():384-8.
2012: Takahiko Yasuda; Tomoki Naoe
[Pathogenesis of acute myeloid leukemia].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 2():379-83.
2012: Satoshi Nishiwaki; Yukiyasu Ozawa; Shigeki Saito; Aika Seto; Kyoko Sugimoto; Emi Yokohata; T Nishida; Tatsunori Goto; Nobuhiko Imahashi; Masafumi Ito; Sonoko Kamoshita; Tomonori Kato; Daisuke Koyama; Naomi Kubota; Kimikazu Matsumoto; Koichi Miyamura; Hiroki Mizuno; Makoto Murata; Takayuki Nakayama; Tomoki Naoe
Dexamethasone palmitate successfully attenuates hemophagocytic syndrome after allogeneic stem cell transplantation: macrophage-targeted steroid therapy.
International journal of hematology 2012;95(4):428-33.
2012: Tomohiro Kajiguchi; Akira Katsumi; Hitoshi Kiyoi; Ryohei Tanizaki; Tomoki Naoe
Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin.
European journal of haematology 2012;88(4):314-20.
2012: Chisako Iriyama; Hitoshi Kiyoi; Mizuho Adachi-Shirahata; Yoko Furukawa-Hibi; Hideaki Hoshino; Akihiro Tomita; Kiyofumi Yamada; Tomoki Naoe
Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome.
Biochemical and biophysical research communications 2012;419(4):662-9.
2012: Takashi Tokunaga; Kazuhito Yamamoto; Dai Chihara; Takuji Ichihashi; Atsushi Isoda; Toshihiro Iwasaki; Kunio Kitamura; Hikaru Kobayashi; Taro Masunari; Kosei Matsue; Shigeo Nakamura; Tomoki Naoe; Rika Oshima; Yoshio Saburi; Akira Sakai; Kazuyuki Shimada; Sadahiro Tamashima; Mitsune Tanimoto; Masafumi Taniwaki; Tomohiro Kinoshita
Retrospective analysis of prognostic factors for angioimmunoblastic T-cell lymphoma: a multicenter cooperative study in Japan.
Blood 2012;119(12):2837-43.
2012: Tomonori Kato; Miho Murase; Makoto Murata; Tetsuya Nishida; Kyoko Sugimoto; Momoko Suzuki; Seitaro Terakura; Akihiro Tomita; Akihiro Abe; Chisako Iriyama; Tomoki Naoe
Escape of leukemia blasts from HLA-specific CTL pressure in a recipient of HLA one locus-mismatched bone marrow transplantation.
Cellular immunology 2012;276(1-2):75-82.
2012: Asahito Hama; Monika Jasek; Koji Kato; Hitoshi Kiyoi; Seiji Kojima; Sayoko Doisaki; Hideki Makishima; Hideki Muramatsu; Tomoki Naoe; Christine L O'Keefe; Hirotoshi Sakaguchi; Akira Shimada; Yuka Sugimoto; Hadrian Szpurka; Yoshiyuki Takahashi; Nobuhiro Watanabe; Jaroslaw P Maciejewski
Molecular lesions in childhood and adult acute megakaryoblastic leukaemia.
British journal of haematology 2012;156(3):316-25.
2011: M Murase; Makoto Murata; T Nishida; M Onizuka; K Sugimoto; N Imahashi; Yoshihiro Inamoto; H Inoko; Yoshihisa Kodera; Koichi Miyamura; Tomoki Naoe
Cytotoxic T-lymphocyte antigen 4 haplotype correlates with relapse and survival after allogeneic hematopoietic SCT.
Bone marrow transplantation 2011;46(11):1444-9.
2011: Shigeki Saito; Satoshi Nishiwaki; Kensuke Egashira; Minoru Hasegawa; Yoshinori Hasegawa; Naozumi Hashimoto; Yasuhiko Miyata; Norihiko Nakao; Takayuki Nakayama; Tomoki Naoe
Mesenchymal stem cells stably transduced with a dominant-negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage.
The American journal of pathology 2011;179(3):1088-94.
2011: Emi Goto; Fumihiko Hayakawa; Hitoshi Kiyoi; Akihide Atsumi; Akihiro Tomita; Tomoki Naoe
Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment.
Blood 2011;118(6):1600-9.
2011: Yuichi Ishikawa; Hitoshi Kiyoi; Tomoki Naoe
Prevalence and clinical characteristics of N-terminally truncated WT1 expression in acute myeloid leukemia.
Leukemia research 2011;35(5):685-8.
2011: S Kurahashi; Fumio Hayakawa; Y Miyata; T Yasuda; Y Minami; S Tsuzuki; Akihiro Abe; Tomoki Naoe
PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML.
Oncogene 2011;30(15):1822-30.
2011: Shuichi Mizuta; K Matsuo; F Yagasaki; T Yujiri; Y Hatta; Y Kimura; Y Ueda; H Kanamori; N Usui; H Akiyama; Y Miyazaki; S Ohtake; Yoshiko Atsuta; Hisashi Sakamaki; K Kawa; Yasuo Morishima; K Ohnishi; Tomoki Naoe; R Ohno
Pre-transplant imatinib-based therapy improves the outcome of allogeneic hematopoietic stem cell transplantation for BCR-ABL-positive acute lymphoblastic leukemia.
Leukemia 2011;25(1):41-7.
2010: Yosuke Minami; Tomohiro Kajiguchi; Akihiro Abe; Toshihito Ohno; Hitoshi Kiyoi; Tomoki Naoe
Expanded distribution of the T315I mutation among hematopoietic stem cells and progenitors in a chronic myeloid leukemia patient during imatinib treatment.
International journal of hematology 2010;92(4):664-6.
2010: Akane Tsujimura; Hitoshi Kiyoi; Yukimasa Shiotsu; Yuichi Ishikawa; Yumiko Mori; Hiroshi Ishida; Tsutomu Toki; Etsuro Ito; Tomoki Naoe
Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia.
International journal of hematology 2010;92(4):624-33.
2010: Yuichi Ishikawa; Hitoshi Kiyoi; Keisuke Watanabe; Koichi Miyamura; Yasuyuki Nakano; Kunio Kitamura; Akio Kohno; Isamu Sugiura; Toshiya Yokozawa; Akitoshi Hanamura; Kazuhito Yamamoto; Hiroatsu Iida; Nobuhiko Emi; Ritsuro Suzuki; Kazunori Ohnishi; Tomoki Naoe
Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: a report from the BINGO study.
Cancer science 2010;101(10):2186-92.
2010: Yuhri Miyawaki; Atsuo Suzuki; Yuhta Fujimori; Akira Takagi; Takashi Murate; Nobuaki Suzuki; Akira Katsumi; Tomoki Naoe; Koji Yamamoto; Tadashi Matsushita; Junki Takamatsu; Tetsuhito Kojima
Severe hemophilia A in a Japanese female caused by an F8-intron 22 inversion associated with skewed X chromosome inactivation.
International journal of hematology 2010;92(2):405-8.
2010: Norihiko Nakao; Takayuki Nakayama; Takashi Yahata; Yukari Muguruma; Shigeki Saito; Yasuhiko Miyata; Koji Yamamoto; Tomoki Naoe
Adipose tissue-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo: advantages over bone marrow-derived mesenchymal stem cells.
The American journal of pathology 2010;177(2):547-54.
2010: Kazuyuki Shimada; Takuhei Murase; Kosei Matsue; Masataka Okamoto; Naoaki Ichikawa; Norifumi Tsukamoto; Nozomi Niitsu; Hiroshi Miwa; Hideki Asaoku; Hiroshi Kosugi; Ako Kikuchi; Morio Matsumoto; Yoshio Saburi; Yasufumi Masaki; Kazuhito Yamamoto; Motoko Yamaguchi; Shigeo Nakamura; Tomoki Naoe; Tomohiro Kinoshita
Central nervous system involvement in intravascular large B-cell lymphoma: a retrospective analysis of 109 patients.
Cancer science 2010;101(6):1480-6.
2010: Ryohei Tanizaki; Yuka Nomura; Yasuhiko Miyata; Yosuke Minami; Akihiro Abe; Akitoshi Hanamura; Masashi Sawa; Makoto Murata; Hitoshi Kiyoi; Tadashi Matsushita; Tomoki Naoe
Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD/SCID/IL-2Rgammac-/- mice.
Cancer science 2010;101(3):631-8.
2010: Momoko Suzuki; Akihiro Abe; Shizuka Imagama; Yuka Nomura; Ryohei Tanizaki; Yosuke Minami; Fumihiko Hayakawa; Yoshie Ito; Akira Katsumi; Kazuhito Yamamoto; Nobuhiko Emi; Hitoshi Kiyoi; Tomoki Naoe
BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4.
European journal of haematology 2010;84(3):229-38.
2010: Ryoko Tanaka; Daisuke Nakashima; Atsuo Suzuki; Yuhri Miyawaki; Yuta Fujimori; Takayuki Yamada; Akira Takagi; Takashi Murate; Koji Yamamoto; Akira Katsumi; Tadashi Matsushita; Tomoki Naoe; Tetsuhito Kojima
Impaired secretion of carboxyl-terminal truncated factor VII due to an F7 nonsense mutation associated with FVII deficiency.
Thrombosis research 2010;125(3):262-6.
2010: Y Inamoto; Makoto Murata; A Katsumi; Yachiyo Kuwatsuka; Akane Tsujimura; Y Ishikawa; K Sugimoto; M Onizuka; Seitaro Terakura; T Nishida; Tadaharu Kanie; Hirofumi Taji; Hiroatsu Iida; Ritsuro Suzuki; Akihiro Abe; Hitoshi Kiyoi; T Matsushita; Koichi Miyamura; Yoshihisa Kodera; Tomoki Naoe
Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD.
Bone marrow transplantation 2010;45(2):363-9.
2010: Mikito Takefuji; Hiroyuki Asano; Kazutaka Mori; Mutsuki Amano; Katsuhiro Kato; Takashi Watanabe; Yasuhiro Morita; Akira Katsumi; Toshiki Itoh; Tadaomi Takenawa; Akihiro Hirashiki; Hideo Izawa; Kozo Nagata; Haruo Hirayama; Fumimaro Takatsu; Tomoki Naoe; Mitsuhiro Yokota; Kozo Kaibuchi
Mutation of ARHGAP9 in patients with coronary spastic angina.
Journal of human genetics 2010;55(1):42-9.
2009: Takumi Sugimoto; Akihiro Tomita; Junji Hiraga; Kazuyuki Shimada; Hitoshi Kiyoi; Tomohiro Kinoshita; Tomoki Naoe
Escape mechanisms from antibody therapy to lymphoma cells: downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation.
Biochemical and biophysical research communications 2009;390(1):48-53.
2009: Kyoko Sugimoto; Makoto Murata; Seitaro Terakura; Tomoki Naoe
CTL clones isolated from an HLA-Cw-mismatched bone marrow transplant recipient with acute graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):5991-8.
2009: Kazuyuki Shimada; Tomohiro Kinoshita; Tomoki Naoe; Shigeo Nakamura
Presentation and management of intravascular large B-cell lymphoma.
The lancet oncology 2009;10(9):895-902.
2009: Yuichi Ishikawa; Hitoshi Kiyoi; Akane Tsujimura; Shuichi Miyawaki; Yasushi Miyazaki; Kazutaka Kuriyama; Masao Tomonaga; Tomoki Naoe
Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia.
European journal of haematology 2009;83(2):90-8.
2009: A Furuhata; M Murakami; H Ito; S Gao; K Yoshida; S Sobue; R Kikuchi; T Iwasaki; A Takagi; Tetsuhito Kojima; M Suzuki; Akihiro Abe; Tomoki Naoe; Takashi Murate
GATA-1 and GATA-2 binding to 3' enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines.
Leukemia 2009;23(7):1270-7.
2009: Yoshihiro Inamoto; M Ito; Ritsuro Suzuki; T Nishida; Hiroatsu Iida; A Kohno; M Sawa; M Murata; S Nishiwaki; Taku Oba; M Yanada; Tomoki Naoe; R Ichihashi; M Fujino; T Yamaguchi; Yoshihisa Morishita; Noriyuki Hirabayashi; Yoshihisa Kodera; Koichi Miyamura
Clinicopathological manifestations and treatment of intestinal transplant-associated microangiopathy.
Bone marrow transplantation 2009;44(1):43-9.
2009: Atsunori Furuhata; A Kimura; K Shide; K Shimoda; Masashi Murakami; H Ito; S Gao; K Yoshida; Y Tagawa; K Hagiwara; Akira Takagi; Tetsuhito Kojima; Motoshi Suzuki; Akihiro Abe; Tomoki Naoe; Takashi Murate
p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation.
Biochemical and biophysical research communications 2009;383(4):411-6.
2009: Arinobu Tojo; Kensuke Usuki; Akio Urabe; Yasuhiro Maeda; Yukio Kobayashi; Itsuro Jinnai; Kazuma Ohyashiki; Miki Nishimura; Tatsuya Kawaguchi; Hideo Tanaka; Koichi Miyamura; Yasushi Miyazaki; Timothy Hughes; Susan Branford; Shinichiro Okamoto; Jun Ishikawa; Masaya Okada; Noriko Usui; Hiromi Tanii; Taro Amagasaki; Hiroko Natori; Tomoki Naoe
A Phase I/II study of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL.
International journal of hematology 2009;89(5):679-88.
2009: Junji Hiraga; Akihiro Tomita; Takumi Sugimoto; Kazuyuki Shimada; Masafumi Ito; Shigeo Nakamura; Hitoshi Kiyoi; Tomohiro Kinoshita; Tomoki Naoe
Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance.
Blood 2009;113(20):4885-93.
2009: Yoshihiro Inamoto; Shingo Kurahashi; Nobuhiko Imahashi; Nobuaki Fukushima; Tatsuya Adachi; Tomohiro Kinoshita; Keitaro Tsushita; Koichi Miyamura; Tomoki Naoe; Isamu Sugiura
Combinations of cytogenetics and international scoring system can predict poor prognosis in multiple myeloma after high-dose chemotherapy and autologous stem cell transplantation.
American journal of hematology 2009;84(5):283-6.
2009: Yosuke Minami; Tomoki Naoe
[Circumventing resistance to imatinib therapy in chronic myeloid leukemia].
Gan to kagaku ryoho. Cancer & chemotherapy 2009;36(4):544-7.
2009: Masamitsu Yanada; Ryuzo Ohno; Tomoki Naoe
Recent advances in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.
International journal of hematology 2009;89(1):3-13.
2008: Yuichi Ishikawa; Jinglan Xu; Gyosuke Sakashita; Takeshi Urano; Tatsuya Suzuki; Akihiro Tomita; Hitoshi Kiyoi; Shigeo Nakamura; Tomoki Naoe
Abnormal cytoplasmic dyslocalisation and/or reduction of nucleophosmin protein level rarely occurs in myelodysplastic syndromes.
Leukemia & lymphoma 2008;49(12):2359-64.
2008: Akihiro Abe; Yosuke Minami; Fumihiko Hayakawa; Kunio Kitamura; Yuka Nomura; Makoto Murata; Akira Katsumi; Hitoshi Kiyoi; Catriona H M Jamieson; Jean Y J Wang; Tomoki Naoe
Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy.
International journal of hematology 2008;88(5):471-5.
2008: Toshihiro Iwasaki; Akira Katsumi; Hitoshi Kiyoi; Ryohei Tanizaki; Yuichi Ishikawa; Kazutaka Ozeki; Miki Kobayashi; Akihiro Abe; Tadashi Matsushita; Takashi Watanabe; Mutsuki Amano; Tetsuhito Kojima; Kozo Kaibuchi; Tomoki Naoe
Prognostic implication and biological roles of RhoH in acute myeloid leukaemia.
European journal of haematology 2008;81(6):454-60.
2008: Yosuke Minami; Scott A Stuart; Tomokatsu Ikawa; Yong Jiang; Asoka Banno; Irina C Hunton; Dennis J Young; Tomoki Naoe; Cornelis Murre; Catriona H M Jamieson; Jean Y J Wang
BCR-ABL-transformed GMP as myeloid leukemic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17967-72.
2008: Masamitsu Yanada; Isamu Sugiura; Jin Takeuchi; Hideki Akiyama; Atsuo Maruta; Yasunori Ueda; Noriko Usui; Fumiharu Yagasaki; Toshiaki Yujiri; Makoto Takeuchi; Kazuhiro Nishii; Yukihiko Kimura; Shuichi Miyawaki; Hiroto Narimatsu; Yasushi Miyazaki; Shigeki Ohtake; Itsuro Jinnai; Keitaro Matsuo; Tomoki Naoe; Ryuzo Ohno
Prospective monitoring of BCR-ABL1 transcript levels in patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia undergoing imatinib-combined chemotherapy.
British journal of haematology 2008;143(4):503-10.
2008: Ryohei Tanizaki; Akira Katsumi; Hitoshi Kiyoi; Shinji Kunishima; Toshihiro Iwasaki; Yuichi Ishikawa; Miki Kobayashi; Akihiro Abe; Tadashi Matsushita; Takashi Watanabe; Tetsuhito Kojima; Kozo Kaibuchi; Seiji Kojima; Tomoki Naoe
Mutational analysis of SOS1 gene in acute myeloid leukemia.
International journal of hematology 2008;88(4):460-2.
2008: Hiroshi Ishida; Shoichi Isami; Tsutomu Matsumura; Hiroshi Umehara; Yoshinori Yamashita; Jiro Kajita; Eiichi Fuse; Hitoshi Kiyoi; Tomoki Naoe; Shiro Akinaga; Yukimasa Shiotsu; Hitoshi Arai
Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(20):5472-7.
2008: Shiro Akinaga; Yukimasa Shiotsu; Hitoshi Kiyoi; Tomoki Naoe
[FLT3 tyrosine kinase inhibitors: current status and future perspectives for their development].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2008;132(4):217-20.
2008: Fumihiko Hayakawa; Akihiro Abe; Issay Kitabayashi; Pier Paolo Pandolfi; Tomoki Naoe
Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis.
The Journal of biological chemistry 2008;283(36):24420-5.
2008: Hiroto Narimatsu; Masaki Iino; Takuji Ichihashi; Toshiya Yokozawa; Masaya Hayakawa; Hitoshi Kiyoi; Takaaki Takeo; Akiyo Sawamoto; Hiroatsu Iida; Motohiro Tsuzuki; Masamitsu Yanada; Tomoki Naoe; Ritsuro Suzuki; Isamu Sugiura
Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan.
International journal of hematology 2008;88(2):154-8.
2008: Kazuyuki Shimada; Hiroshi Kosugi; Satoko Shimada; Hiroto Narimatsu; Yoshitsugu Koyama; Nobuaki Suzuki; Masaaki Yuge; Hironori Nishibori; Yosuke Iwata; Shigeo Nakamura; Tomoki Naoe; Tomohiro Kinoshita
Evaluation of organ involvement in intravascular large B-cell lymphoma by 18F-fluorodeoxyglucose positron emission tomography.
International journal of hematology 2008;88(2):149-53.
2008: Moritaka Gotoh; Yuko Sasaki; Tomotaka Iguchi; Hiroaki Fujimoto; Atsushi Kodama; Hitoshi Kiyoi; Tomoki Naoe; Kazuma Ohyashiki
Karyotypically independent clones with del(11q) and trisomy 10 in acute myeloid leukemia: trisomy 10 may appear as an additional change.
International journal of hematology 2008;88(1):123-4.
2008: Kazuyuki Shimada; Kosei Matsue; Kazuhito Yamamoto; Takuhei Murase; Naoaki Ichikawa; Masataka Okamoto; Nozomi Niitsu; Hiroshi Kosugi; Norifumi Tsukamoto; Hiroshi Miwa; Hideki Asaoku; Ako Kikuchi; Morio Matsumoto; Yoshio Saburi; Yasufumi Masaki; Motoko Yamaguchi; Shigeo Nakamura; Tomoki Naoe; Tomohiro Kinoshita
Retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(19):3189-95.
2008: Makoto Murata; Yuichi Ishikawa; Haruhiko Ohashi; Seitaro Terakura; Kazutaka Ozeki; Hitoshi Kiyoi; Tomoki Naoe
Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review.
International journal of hematology 2008;88(1):111-5.
2008: Kyoko Sugimoto; Makoto Murata; Makoto Onizuka; Yoshihiro Inamoto; Seitaro Terakura; Yachiyo Kuwatsuka; Taku Oba; Koichi Miyamura; Yoshihisa Kodera; Tomoki Naoe
Decreased risk of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in patients with the 5,10-methylenetetrahydrofolate reductase 677TT genotype.
International journal of hematology 2008;87(5):451-8.
2008: Takayuki Nakayama; Tadashi Matsushita; Koji Yamamoto; Noriko Mutsuga; Tetsuhito Kojima; Akira Katsumi; Norihiko Nakao; J Evan Sadler; Tomoki Naoe; Hidehiko Saito
Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis.
International journal of hematology 2008;87(4):363-70.
2008: Kazuyuki Shimada; Hiroshi Kosugi; Hiroto Narimatsu; Satoko Shimada; Tatsuya Suzuki; Masafumi Ito; Tomohiro Kinoshita; Naoyoshi Mori; Tomoki Naoe
Sustained remission after rituximab-containing chemotherapy for intravascular large B-cell lymphoma.
Journal of clinical and experimental hematopathology : JCEH 2008;48(1):25-8.
2008: Hiroto Narimatsu; Makoto Murata; Seitaro Terakura; Kyoko Sugimoto; Tomoki Naoe
Potential role of a mismatched HLA-specific CTL clone developed pre-transplant in graft rejection following cord blood transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008;14(4):397-402.
2008: K Sugimoto; Hiroto Narimatsu; T Kawase; Hiroatsu Iida; M Watanabe; Akio Kohno; Yachiyo Kuwatsuka; T Uchida; M Hamaguchi; Seitaro Terakura; Tomoki Naoe; K Matsuo; Makoto Murata; M Sawa; Koichi Miyamura; Yoshihisa Morishita
Clinical characteristics of chronic graft-versus-host disease following umbilical cord blood transplantation for adults.
Bone marrow transplantation 2008;41(8):729-36.
2008: Akio Kohno; Yoshihisa Morishita; Hiroatsu Iida; Masamitsu Yanada; Toshiki Uchida; Motohiro Hamaguchi; Masashi Sawa; Isamu Sugiura; Kazuhito Yamamoto; Shuichi Mizuta; Hiroshi Sao; Tomoki Naoe; Koichi Miyamura
Hematopoietic stem cell transplantation for acute promyelocytic leukemia in second or third complete remission: a retrospective analysis in the Nagoya Blood and Marrow Transplantation Group.
International journal of hematology 2008;87(2):210-6.
2008: Moe Wakui; Kazutaka Kuriyama; Yasushi Miyazaki; Tomoko Hata; Masafumi Taniwaki; Shigeki Ohtake; Hisashi Sakamaki; Shuichi Miyawaki; Tomoki Naoe; Ryuzo Ohno; Masao Tomonaga
Diagnosis of acute myeloid leukemia according to the WHO classification in the Japan Adult Leukemia Study Group AML-97 protocol.
International journal of hematology 2008;87(2):144-51.
2008: Masamitsu Yanada; Jin Takeuchi; Isamu Sugiura; Hideki Akiyama; Noriko Usui; Fumiharu Yagasaki; Kazuhiro Nishii; Yasunori Ueda; Makoto Takeuchi; Shuichi Miyawaki; Atsuo Maruta; Hiroto Narimatsu; Yasushi Miyazaki; Shigeki Ohtake; Itsuro Jinnai; Keitaro Matsuo; Tomoki Naoe; Ryuzo Ohno
Karyotype at diagnosis is the major prognostic factor predicting relapse-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy.
Haematologica 2008;93(2):287-90.
2008: Jinglan Xu; Momoko Suzuki; Yousuke Niwa; Junji Hiraga; Tetsuro Nagasaka; Masafumi Ito; Shigeo Nakamura; Akihiro Tomita; Akihiro Abe; Hitoshi Kiyoi; Tomohiro Kinoshita; Tomoki Naoe
Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome.
British journal of haematology 2008;140(4):394-401.
2008: H Narimatsu; T Yokozawa; H Iida; M Tsuzuki; M Hayakawa; T Takeo; M Iino; T Ichihashi; C Kato; Akiyo Sawamoto; Hiroshi Sao; Masamitsu Yanada; Nobuhiko Emi; Hitoshi Kiyoi; T Yamaguchi; Tomoki Naoe; R Suzuki; Isamu Sugiura
Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan.
Leukemia 2008;22(2):428-32.
2007: Tomohiro Kajiguchi; Eun Joo Chung; Sunmin Lee; A Stine; Hitoshi Kiyoi; Tomoki Naoe; Mark Levis; Len Neckers; Jane Trepel
FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells.
Leukemia 2007;21(12):2476-84.
2007: Takashi Iwasaki; Chiho Sugisaki; Kohzo Nagata; Kenji Takagi; Akira Takagi; Tetsuhito Kojima; Masafumi Ito; Shigeo Nakamura; Tomoki Naoe; Takashi Murate
Wilms' tumor 1 message and protein expression in bone marrow failure syndrome and acute leukemia.
Pathology international 2007;57(10):645-51.
2007: Hiroto Narimatsu; Nobuhiko Emi; Akio Kohno; M Iwai; Masamitsu Yanada; T Yokozawa; S Saito; K Shimada; Hitoshi Kiyoi; Tomoki Naoe; K Yamamoto; Yoshihisa Morishita
High incidence of secondary failure of platelet recovery after autologous and syngeneic peripheral blood stem cell transplantation in acute promyelocytic leukemia.
Bone marrow transplantation 2007;40(8):773-8.
2007: Takashi Oyama; Kazuhito Yamamoto; Naoko Asano; Aya Oshiro; Ritsuro Suzuki; Yoshitoyo Kagami; Yasuo Morishima; Kengo Takeuchi; Toshiyuki Izumo; Shigeo Mori; Koichi Ohshima; Junji Suzumiya; Naoya Nakamura; Masafumi Abe; Koichi Ichimura; Yumiko Sato; Tadashi Yoshino; Tomoki Naoe; Yoshie Shimoyama; Yoshikazu Kamiya; Tomohiro Kinoshita; Shigeo Nakamura
Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: a study of 96 patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(17):5124-32.
2007: Naomi Sanda; Yuta Fujimori; Takahiro Kashiwagi; Akira Takagi; Takashi Murate; Emi Mizutani; Tadashi Matsushita; Tomoki Naoe; Tetsuhito Kojima
An Sp1 binding site mutation of the PROS1 promoter in a patient with protein S deficiency.
British journal of haematology 2007;138(5):663-5.
2007: Hitoshi Kiyoi; Yukimasa Shiotsu; Kazutaka Ozeki; Satomi Yamaji; Hiroshi Kosugi; Hiroshi Umehara; Makiko Shimizu; Hitoshi Arai; Kenichi Ishii; Shiro Akinaga; Tomoki Naoe
A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(15 Pt 1):4575-82.
2007: Hitoshi Zembutsu; Masamitsu Yanada; Asahi Hishida; Toyomasa Katagiri; Takashi Tsuruo; Isamu Sugiura; Jin Takeuchi; Noriko Usui; Tomoki Naoe; Yusuke Nakamura; Ryuzo Ohno
Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy.
International journal of oncology 2007;31(2):313-22.
2007: Junji Hiraga; Akira Katsumi; T Iwasaki; Akihiro Abe; Hitoshi Kiyoi; T Matsushita; Tomohiro Kinoshita; Tomoki Naoe
Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma.
Leukemia 2007;21(8):1846-7.
2007: Akihiro Tomita; Junji Hiraga; Hitoshi Kiyoi; Manabu Ninomiya; Takumi Sugimoto; Masafumi Ito; Tomohiro Kinoshita; Tomoki Naoe
Epigenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with rituximab-containing chemotherapy.
International journal of hematology 2007;86(1):49-57.
2007: Seitaro Terakura; Eiichi Azuma; Makoto Murata; Tadashi Kumamoto; Masahiro Hirayama; Yoshiko Atsuta; Yoshihisa Kodera; Makoto Yazaki; Tomoki Naoe; Koji Kato
Hematopoietic engraftment in recipients of unrelated donor umbilical cord blood is affected by the CD34+ and CD8+ cell doses.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(7):822-30.
2007: Shizuka Imagama; Akihiro Abe; Momoko Suzuki; Fumihiko Hayakawa; Akira Katsumi; Nobuhiko Emi; Hitoshi Kiyoi; Tomoki Naoe
LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22).
European journal of haematology 2007;79(1):25-31.
2007: Masamitsu Yanada; Itsuro Jinnai; Jin Takeuchi; Takanori Ueda; Shuichi Miyawaki; Motohiro Tsuzuki; Yoshihiro Hatta; Noriko Usui; Hideho Wada; Takeshi Morii; Mitsuhiro Matsuda; Hitoshi Kiyoi; Masaya Okada; Sumihisa Honda; Yasushi Miyazaki; Ryuzo Ohno; Tomoki Naoe
Clinical features and outcome of T-lineage acute lymphoblastic leukemia in adults: a low initial white blood cell count, as well as a high count predict decreased survival rates.
Leukemia research 2007;31(7):907-14.
2007: Kazuhito Yamamoto; Nobuhiko Emi; Tomohiro Kajiguchi; Shunji Yamamori; Yoshitaka Ono; Tomoki Naoe
Eosinophils derived from acute promyelocytic leukemia cells after arsenic trioxide treatment.
International journal of hematology 2007;85(5):456-7.
2007: Seitaro Terakura; Makoto Murata; Edus H Warren; Alessandro Sette; John Sidney; Tomoki Naoe; Stanley R Riddell
A single minor histocompatibility antigen encoded by UGT2B17 and presented by human leukocyte antigen-A*2902 and -B*4403.
Transplantation 2007;83(9):1242-8.
2007: Masamitsu Yanada; Tadashi Matsushita; Norio Asou; Yuji Kishimoto; Motohiro Tsuzuki; Yasuhiro Maeda; Kentaro Horikawa; Masaya Okada; Shigeki Ohtake; Fumiharu Yagasaki; Tadashi Matsumoto; Yukihiko Kimura; Katsuji Shinagawa; Masako Iwanaga; Yasushi Miyazaki; Ryuzo Ohno; Tomoki Naoe
Severe hemorrhagic complications during remission induction therapy for acute promyelocytic leukemia: incidence, risk factors, and influence on outcome.
European journal of haematology 2007;78(3):213-9.
2007: M Okamoto; Fumihiko Hayakawa; Y Miyata; K Watamoto; Nobuhiko Emi; Akihiro Abe; Hitoshi Kiyoi; Masayuki Towatari; Tomoki Naoe
Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD.
Leukemia 2007;21(3):403-10.
2007: Masahiro Kajiguchi; Takahisa Kondo; Hideo Izawa; Masayoshi Kobayashi; Koji Yamamoto; Satoshi Shintani; Yasushi Numaguchi; Tomoki Naoe; Junki Takamatsu; Kimihiro Komori; Toyoaki Murohara
Safety and efficacy of autologous progenitor cell transplantation for therapeutic angiogenesis in patients with critical limb ischemia.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(2):196-201.
2007: Tatsuya Suzuki; Tomoki Naoe
[Acute leukemia].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 1():68-74.
2007: Yoshihiro Inamoto; T Nishida; Ritsuro Suzuki; Koichi Miyamura; Hiroshi Sao; Hiroatsu Iida; Tomoki Naoe; F Maruyama; Noriyuki Hirabayashi; M Hamaguchi; T Iseki; M Kami; K Yano; H Takeyama; Yoshihisa Morishita; Yasuo Morishima; Yoshihisa Kodera
Significance of additional high-dose cytarabine in combination with cyclophosphamide plus total body irradiation regimen for allogeneic stem cell transplantation.
Bone marrow transplantation 2007;39(1):25-30.
2007: Manabu Ninomiya; Akihiro Abe; Akira Katsumi; J Xu; M Ito; F Arai; T Suda; M Ito; Hitoshi Kiyoi; Tomohiro Kinoshita; Tomoki Naoe
Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice.
Leukemia 2007;21(1):136-42.
2006: Fumihiko Hayakawa; Tomoki Naoe
SFK-STAT pathway: an alternative and important way to malignancies.
Annals of the New York Academy of Sciences 2006;1086():213-22.
2006: Akihiro Abe; Hitoshi Kiyoi; Manabu Ninomiya; Tomio Yamazaki; Takuhei Murase; Kazutaka Ozeki; Momoko Suzuki; Fumihiko Hayakawa; Akira Katsumi; Nobuhiko Emi; Tomoki Naoe
Establishment of a stroma-dependent human acute myelomonocytic leukemia cell line, NAMO-2, with FLT3 tandem duplication.
International journal of hematology 2006;84(4):328-36.
2006: Manabu Ninomiya; Tomohiro Kajiguchi; Kazuhito Yamamoto; Tomohiro Kinoshita; Nobuhiko Emi; Tomoki Naoe
Increased oxidative DNA products in patients with acute promyelocytic leukemia during arsenic therapy.
Haematologica 2006;91(11):1571-2.
2006: S Sobue; T Iwasaki; Chiho Sugisaki; K Nagata; R Kikuchi; M Murakami; A Takagi; T Kojima; Y Banno; Y Akao; Y Nozawa; R Kannagi; M Suzuki; A Abe; Tomoki Naoe; Takashi Murate
Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes.
Leukemia 2006;20(11):2042-6.
2006: Tomoki Naoe
Developing target therapy against oncogenic tyrosine kinase in myeloid maliganacies.
Current pharmaceutical biotechnology 2006;7(5):331-7.
2006: Junji Hiraga; Tomohiro Kinoshita; Toshihito Ohno; Naoyoshi Mori; Haruhiko Ohashi; Shouko Fukami; Atsuhiko Noda; Atsushi Ichikawa; Tomoki Naoe
Promoter hypermethylation of the DNA-repair gene O6-methylguanine-DNA methyltransferase and p53 mutation in diffuse large B-cell lymphoma.
International journal of hematology 2006;84(3):248-55.
2006: Tomoki Naoe; Tatsuya Suzuki; Hitoshi Kiyoi; Takeshi Urano
Nucleophosmin: a versatile molecule associated with hematological malignancies.
Cancer science 2006;97(10):963-9.
2006: Masamitsu Yanada; Tadashi Matsushita; Momoko Suzuki; Hitoshi Kiyoi; Koji Yamamoto; Tomohiro Kinoshita; Tetsuhito Kojima; Hidehiko Saito; Tomoki Naoe
Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation.
European journal of haematology 2006;77(4):282-7.
2006: Masamitsu Yanada; Tomoki Naoe
Imatinib combined chemotherapy for Philadelphia chromosome-positive acute lymphoblastic leukemia: major challenges in current practice.
Leukemia & lymphoma 2006;47(9):1747-53.
2006: H Okada; Tomio Yamazaki; Akira Takagi; Takashi Murate; Koji Yamamoto; Junki Takamatsu; Tadashi Matsushita; Tomoki Naoe; S Kunishima; M Hamaguchi; Hidehiko Saito; Tetsuhito Kojima
In vitro characterization of missense mutations associated with quantitative protein S deficiency.
Journal of thrombosis and haemostasis : JTH 2006;4(9):2003-9.
2006: Hideo Izawa; Takahisa Kondo; Akihiko Usui; Koji Yamamoto; Satoshi Shintani; Yasuya Inden; Satoshi Isobe; Kazumasa Unno; Masahiro Kajiguchi; Tomoko Kato; Akiko Noda; Kenji Okumura; Tomoki Naoe; Junki Takamatsu; Kimihiro Komori; Yuichi Ueda; Toyoaki Murohara
Clinical protocol for angiogenesis by intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe coronary artery disease: TACT-NAGOYA-HEART.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(9):1180-3.
2006: Tomoko Yamamoto; Mariko Isomura; Yinyan Xu; Juan Liang; Hiroshi Yagasaki; Yoshiro Kamachi; Kazuko Kudo; Hitoshi Kiyoi; Tomoki Naoe; Seiji Kojma
PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia.
Leukemia research 2006;30(9):1085-9.
2006: Akira Katsumi; Tadashi Matsushita; Kanji Hirashima; Toshihiro Iwasaki; Tatsuya Adachi; Koji Yamamoto; Tetsuhito Kojima; Junki Takamatsu; Hidehiko Saito; Tomoki Naoe
Recurrent intramural hematoma of the small intestine in a severe hemophilia A patient with a high titer of factor VIII inhibitor: a case report and review of the literature.
International journal of hematology 2006;84(2):166-9.
2006: Manabu Ninomiya; Akihiro Abe; Toshiya Yokozawa; Kazutaka Ozeki; Kazuhito Yamamoto; Masafumi Ito; Masafumi Ito; Hitoshi Kiyoi; Nobuhiko Emi; Tomoki Naoe
Establishment of a myeloid leukemia cell line, TRL-01, with MLL-ENL fusion gene.
Cancer genetics and cytogenetics 2006;169(1):1-11.
2006: Akihide Atsumi; Akihiro Tomita; Hitoshi Kiyoi; Tomoki Naoe
Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo.
Biochemical and biophysical research communications 2006;345(4):1471-80.
2006: Masamitsu Yanada; Keitaro Matsuo; Takeshi Suzuki; Tomoki Naoe
Allogeneic hematopoietic stem cell transplantation as part of postremission therapy improves survival for adult patients with high-risk acute lymphoblastic leukemia: a metaanalysis.
Cancer 2006;106(12):2657-63.
2006: Tadashi Matsushita; Hiroaki Adachi; Hidetaka Watanabe; Yoshie Shimoyama; Tatsuya Adachi; Gen Sobue; Masafumi Ito; Tetsuhito Kojima; Hidehiko Saito; Tomoki Naoe
Classic polyarteritis nodosa presenting rare clinical manifestations in a patient with hemophilia A.
International journal of hematology 2006;83(5):420-5.
2006: Tatsuya Adachi; Tadashi Matsushita; Ryoichi Ichihashi; Kanji Hirashima; Masafumi Ito; Akira Inukai; Toshiya Yokozawa; Tetsuya Nishida; Makoto Murata; Mutsuharu Hayashi; Akira Katsumi; Tetsuhito Kojima; Hidehiko Saito; Tomoki Naoe
High titer of ADAMTS13 inhibitor associated with thrombotic microangiopathy of the gut and skeletal muscle after allogeneic hematopoietic stem cell transplantation.
International journal of hematology 2006;83(5):415-9.
2006: Tomohiro Kajiguchi; Kazuhito Yamamoto; Shinsuke Iida; Ryuzo Ueda; Nobuhiko Emi; Tomoki Naoe
Sustained activation of c-jun-N-terminal kinase plays a critical role in arsenic trioxide-induced cell apoptosis in multiple myeloma cell lines.
Cancer science 2006;97(6):540-5.
2006: Yoshihiro Inamoto; Taku Oba; Koichi Miyamura; Seitaro Terakura; Akane Tsujimura; Yachiyo Kuwatsuka; Masahiro Tokunaga; Masanobu Kasai; Makoto Murata; Tomoki Naoe; Yoshihisa Kodera
Stable engraftment after a conditioning regimen with fludarabine and melphalan for bone marrow transplantation from an unrelated donor.
International journal of hematology 2006;83(4):356-62.
2006: Toshihito Ohno; Junji Hiraga; Haruhiko Ohashi; Chiho Sugisaki; Eika Li; Haruhiko Asano; Tastuya Ito; Hirokazu Nagai; Yoriko Yamashita; Naoyoshi Mori; Tomohiro Kinoshita; Tomoki Naoe
Loss of O6-methylguanine-DNA methyltransferase protein expression is a favorable prognostic marker in diffuse large B-cell lymphoma.
International journal of hematology 2006;83(4):341-7.
2006: Hitoshi Kiyoi; Tomoki Naoe
Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation.
International journal of hematology 2006;83(4):301-8.
2006: Seitaro Terakura; M Murata; T Nishida; Nobuhiko Emi; Yoshiki Akatsuka; Yasuo Morishima; Yoshihisa Kodera; Tomoki Naoe
Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipients.
Bone marrow transplantation 2006;37(4):381-6.
2006: Yoshiko Atsuta; Ritsuro Suzuki; K Yamamoto; Seitaro Terakura; Hiroatsu Iida; Akio Kohno; Tomoki Naoe; K Yano; Atsushi Wakita; Hirofumi Taji; M Hamaguchi; Yoshihisa Kodera; Hiroshi Sao; Yasuo Morishima; Nobuyuki Hamajima; Yoshihisa Morishita
Risk and prognostic factors for Japanese patients with chronic graft-versus-host disease after bone marrow transplantation.
Bone marrow transplantation 2006;37(3):289-96.
2006: Tatsuya Adachi; Tadashi Matsushita; Zhengyu Dong; Akira Katsumi; Takayuki Nakayama; Tetsuhito Kojima; Hidehiko Saito; J Evan Sadler; Tomoki Naoe
Identification of amino acid residues essential for heparin binding by the A1 domain of human von Willebrand factor.
Biochemical and biophysical research communications 2006;339(4):1178-83.
2006: Masamitsu Yanada; Jin Takeuchi; Isamu Sugiura; Hideki Akiyama; Noriko Usui; Fumiharu Yagasaki; Tohru Kobayashi; Yasunori Ueda; Makoto Takeuchi; Shuichi Miyawaki; Atsuo Maruta; Nobuhiko Emi; Yasushi Miyazaki; Shigeki Ohtake; Itsuro Jinnai; Keitaro Matsuo; Tomoki Naoe; Ryuzo Ohno
High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: a phase II study by the Japan Adult Leukemia Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(3):460-6.
2006: Masamitsu Yanada; Hitoshi Kiyoi; Makoto Murata; Momoko Suzuki; Masanori Iwai; Toshiya Yokozawa; Hisashi Baba; Nobuhiko Emi; Tomoki Naoe
Micafungin, a novel antifungal agent, as empirical therapy in acute leukemia patients with febrile neutropenia.
Internal medicine (Tokyo, Japan) 2006;45(5):259-64.
2006: Hitoshi Kiyoi; Tomoki Naoe
FLT3 mutations in acute myeloid leukemia.
Methods in molecular medicine 2006;125():189-97.
2006: M Hayashi; Tadashi Matsushita; Nigel Mackman; M Ito; T Adachi; Akira Katsumi; Koji Yamamoto; K Takeshita; Tetsuhito Kojima; Hidehiko Saito; Toyoaki Murohara; Tomoki Naoe
Fatal thrombosis of antithrombin-deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice.
Journal of thrombosis and haemostasis : JTH 2006;4(1):177-85.
2005: Masamitsu Yanada; Tomoki Naoe; Hiroatsu Iida; Hisashi Sakamaki; T Sakura; H Kanamori; Yoshihisa Kodera; Shinichiro Okamoto; Yoshinobu Kanda; Hiroshi Sao; O Asai; K Nakai; Atsuo Maruta; K Kishi; T Furukawa; Yoshiko Atsuta; K Yamamoto; J Tanaka; S Takahashi
Myeloablative allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: significant roles of total body irradiation and chronic graft-versus-host disease.
Bone marrow transplantation 2005;36(10):867-72.
2005: Tatsuya Suzuki; Hitoshi Kiyoi; Kazutaka Ozeki; Akihiro Tomita; Satomi Yamaji; Ritsuro Suzuki; Yoshihisa Kodera; Shuichi Miyawaki; Norio Asou; Kazutaka Kuriyama; Fumiharu Yagasaki; Chihiro Shimazaki; Hideki Akiyama; Miki Nishimura; Toshiko Motoji; Katsuji Shinagawa; Akihiro Takeshita; Ryuzo Ueda; Tomohiro Kinoshita; Nobuhiko Emi; Tomoki Naoe
Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia.
Blood 2005;106(8):2854-61.
2005: Jinglan Xu; Kohzo Nagata; Koji Obata; Sahoko Ichihara; Hideo Izawa; Akiko Noda; Tetsuro Nagasaka; Mitsunori Iwase; Tomoki Naoe; Toyoaki Murohara; Mitsuhiro Yokota
Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats.
Hypertension 2005;46(4):719-24.
2005: Masamitsu Yanada; Keitaro Matsuo; T Suzuki; Hitoshi Kiyoi; Tomoki Naoe
Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis.
Leukemia 2005;19(8):1345-9.
2005: Asahi Hishida; Seitaro Terakura; Nobuhiko Emi; Kazuhito Yamamoto; Makoto Murata; Kazuko Nishio; Yoshitaka Sekido; Toshimitsu Niwa; Nobuyuki Hamajima; Tomoki Naoe
GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese.
Asian Pacific journal of cancer prevention : APJCP 2005;6(3):251-5.
2005: Masashi Sawa; Kazuhito Yamamoto; Toshiya Yokozawa; Hitoshi Kiyoi; Asahi Hishida; Tomohiro Kajiguchi; Masao Seto; Akio Kohno; Kunio Kitamura; Yoshie Itoh; Norio Asou; Nobuyuki Hamajima; Nobuhiko Emi; Tomoki Naoe
BMI-1 is highly expressed in M0-subtype acute myeloid leukemia.
International journal of hematology 2005;82(1):42-7.
2005: K Shimada; Toshiya Yokozawa; Yoshiko Atsuta; Akio Kohno; F Maruyama; K Yano; Hirofumi Taji; Kenjiro Kitaori; S Goto; Hiroatsu Iida; Yasuo Morishima; Yoshihisa Kodera; Tomoki Naoe; Yoshihisa Morishita
Solid tumors after hematopoietic stem cell transplantation in Japan: incidence, risk factors and prognosis.
Bone marrow transplantation 2005;36(2):115-21.
2005: Masamitsu Yanada; Momoko Suzuki; Kohei Kawashima; Hitoshi Kiyoi; Tomohiro Kinoshita; Nobuhiko Emi; Hidehiko Saito; Tomoki Naoe
Long-term outcomes for unselected patients with acute myeloid leukemia categorized according to the World Health Organization classification: a single-center experience.
European journal of haematology 2005;74(5):418-23.
2005: Masamitsu Yanada; Keitaro Matsuo; Nobuhiko Emi; Tomoki Naoe
Efficacy of allogeneic hematopoietic stem cell transplantation depends on cytogenetic risk for acute myeloid leukemia in first disease remission: a metaanalysis.
Cancer 2005;103(8):1652-8.
2005: Seitaro Terakura; Makoto Murata; Tetsuya Nishida; Nobuhiko Emi; Yoshiki Akatsuka; Stanley R Riddell; Yasuo Morishima; Yoshihisa Kodera; Tomoki Naoe
A UGT2B17-positive donor is a risk factor for higher transplant-related mortality and lower survival after bone marrow transplantation.
British journal of haematology 2005;129(2):221-8.
2005: Makoto Murata; N Emi; Y Izumisawa; A Inaki; M Saitoh; Tomoki Naoe
Identification and frequency of a new HLA-A allele, A*030104.
Tissue antigens 2005;65(4):391-2.
2005: Tomohiro Kajiguchi; Kazuhito Yamamoto; M Sawa; Nobuhiko Emi; Tomoki Naoe
Increased erythropoietin level and reticulocyte count during arsenic trioxide therapy.
Leukemia 2005;19(4):674-6.
2005: Ayako Mitsuma; Haruhiko Asano; Tomohiro Kinoshita; Takashi Murate; Hidehiko Saito; George Stamatoyannopoulos; Tomoki Naoe
Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells.
Biochimica et biophysica acta 2005;1727(2):125-33.
2005: Shinji Kunishima; Tadashi Matsushita; Motoaki Shiratsuchi; Takuya Ikuta; Junji Nishimura; Motohiro Hamaguchi; Tomoki Naoe; Hidehiko Saito
Detection of unique neutrophil non-muscle myosin heavy chain-A localization by immunofluorescence analysis in MYH9 disorder presented with macrothrombocytopenia without leukocyte inclusions and deafness.
European journal of haematology 2005;74(1):1-5.
2004: Tadashi Matsushita; Hideo Hayashi; Shinji Kunishima; Mutsuharu Hayashi; Makoto Ikejiri; Kyosuke Takeshita; Yukio Yuzawa; Tatsuya Adachi; Kanji Hirashima; Michihiko Sone; Koji Yamamoto; Akira Takagi; Akira Katsumi; Kumi Kawai; Tomoyo Nezu; Masahide Takahashi; Tsutomu Nakashima; Tomoki Naoe; Tetsuhito Kojima; Hidehiko Saito
Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice.
Biochemical and biophysical research communications 2004;325(4):1163-71.
2004: Haruhiko Asano; Takashi Murate; Tomoki Naoe; Hidehiko Saito; George Stamatoyannopoulos
Molecular cloning and characterization of ZFF29: a protein containing a unique Cys2His2 zinc-finger motif.
The Biochemical journal 2004;384(Pt 3):647-53.
2004: Tomoki Naoe; Hitoshi Kiyoi
Normal and oncogenic FLT3.
Cellular and molecular life sciences : CMLS 2004;61(23):2932-8.
2004: Masayuki Towatari; Masamitsu Yanada; Noriko Usui; Jin Takeuchi; Isamu Sugiura; Makoto Takeuchi; Fumiharu Yagasaki; Yasukazu Kawai; Shuichi Miyawaki; Shigeki Ohtake; Itsuro Jinnai; Keitaro Matsuo; Tomoki Naoe; Ryuzo Ohno
Combination of intensive chemotherapy and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia.
Blood 2004;104(12):3507-12.
2004: Masamitsu Yanada; Seitaro Terakura; Toshiya Yokozawa; Kazuhito Yamamoto; Hitoshi Kiyoi; Nobuhiko Emi; Kunio Kitamura; Akio Kohno; Masafumi Tanaka; Tadasu Tobita; Takaaki Takeo; Hiroshi Sao; Takae Kataoka; Masahide Kobayashi; Akihiro Takeshita; Yoshihisa Morishita; Tomoki Naoe; Isamu Sugiura
Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia.
Leukemia & lymphoma 2004;45(9):1803-8.
2004: Masamitsu Yanada; Nobuhiko Emi; Tomoki Naoe; Hisashi Sakamaki; S Takahashi; Noriyuki Hirabayashi; Akira Hiraoka; Yoshinobu Kanda; R Tanosaki; Shinichiro Okamoto; Koji Iwato; Yoshiko Atsuta; Nobuyuki Hamajima; Mitsune Tanimoto; S Kato
Tacrolimus instead of cyclosporine used for prophylaxis against graft-versus-host disease improves outcome after hematopoietic stem cell transplantation from unrelated donors, but not from HLA-identical sibling donors: a nationwide survey conducted in Japan.
Bone marrow transplantation 2004;34(4):331-7.
2004: Akihiro Abe; Nobuhiko Emi; Tadaharu Kanie; Shizuka Imagama; Yuji Kuno; Masahide Takahashi; Hidehiko Saito; Tomoki Naoe
Expression cloning of oligomerization-activated genes with cell-proliferating potency by pseudotype retrovirus vector.
Biochemical and biophysical research communications 2004;320(3):920-6.
2004: Masamitsu Yanada; Nobuhiko Emi; Tomoki Naoe; Hisashi Sakamaki; Tohru Iseki; Noriyuki Hirabayashi; Takahiro Karasuno; S Chiba; Yoshiko Atsuta; Nobuyuki Hamajima; S Takahashi; S Kato
Allogeneic myeloablative transplantation for patients aged 50 years and over.
Bone marrow transplantation 2004;34(1):29-35.
2004: Asahi Hishida; Keitaro Matsuo; Kazuo Tajima; Michinori Ogura; Yoshitoyo Kagami; Hirofumi Taji; Yasuo Morishima; Nobuhiko Emi; Tomoki Naoe; Nobuyuki Hamajima
Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's lymphoma in Japanese.
Leukemia & lymphoma 2004;45(5):957-64.
2004: Tadaharu Kanie; Akihiro Abe; Tsukasa Matsuda; Yuji Kuno; Masayuki Towatari; T Yamamoto; Hidehiko Saito; Nobuhiko Emi; Tomoki Naoe
TEL-Syk fusion constitutively activates PI3-K/Akt, MAPK and JAK2-independent STAT5 signal pathways.
Leukemia 2004;18(3):548-55.
2004: Kazutaka Ozeki; Hitoshi Kiyoi; Yuka Hirose; Masanori Iwai; Manabu Ninomiya; Yoshihisa Kodera; Shuichi Miyawaki; Kazutaka Kuriyama; Chihiro Shimazaki; Hideki Akiyama; Miki Nishimura; Toshiko Motoji; Katsuji Shinagawa; Akihiro Takeshita; Ryuzo Ueda; Ryuzo Ohno; Nobuhiko Emi; Tomoki Naoe
Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia.
Blood 2004;103(5):1901-8.
2003: Kouichi Watamoto; Masayuki Towatari; Yukiyasu Ozawa; Yasuhiko Miyata; Mitsunori Okamoto; Akihiro Abe; Tomoki Naoe; Hidehiko Saito
Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation.
Oncogene 2003;22(57):9176-84.
2003: Tomohiro Kajiguchi; Kazuhito Yamamoto; Khaled Hossain; Anwarul A Akhand; Izumi Nakashima; Tomoki Naoe; Hidehiko Saito; Nobuhiko Emi
Sustained activation of c-jun-terminal kinase (JNK) is closely related to arsenic trioxide-induced apoptosis in an acute myeloid leukemia (M2)-derived cell line, NKM-1.
Leukemia 2003;17(11):2189-95.
2003: Yosuke Minami; Kazuhito Yamamoto; Hitoshi Kiyoi; Ryuzo Ueda; Hidehiko Saito; Tomoki Naoe
Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia.
Blood 2003;102(8):2969-75.
2003: Masamitsu Yanada; K Yamamoto; Nobuhiko Emi; Tomoki Naoe; Ritsuro Suzuki; Hirofumi Taji; Hiroatsu Iida; T Shimokawa; Akio Kohno; Shuichi Mizuta; F Maruyama; Atsushi Wakita; Kenjiro Kitaori; K Yano; M Hamaguchi; Nobuyuki Hamajima; Yasuo Morishima; Yoshihisa Kodera; Hiroshi Sao; Yoshihisa Morishita
Cytomegalovirus antigenemia and outcome of patients treated with pre-emptive ganciclovir: retrospective analysis of 241 consecutive patients undergoing allogeneic hematopoietic stem cell transplantation.
Bone marrow transplantation 2003;32(8):801-7.
2003: Kaneyuki Ohbayashi; Masafumi Taniwaki; Manabu Ninomiya; Hitoshi Kiyoi; Shinsuke Iida; Ryuzo Ueda; Tomoki Naoe
A xeno-transplantable plasma cell leukemia line with a split translocation of the IgH gene.
Cancer genetics and cytogenetics 2003;144(1):31-5.
2002: Yuka Hirose; Hitoshi Kiyoi; Masanori Iwai; Toshiya Yokozawa; Masafumi Ito; Tomoki Naoe
Successful treatment with imatinib mesylate of a CML patient in megakaryoblastic crisis with severe fibrosis.
International journal of hematology 2002;76(4):349-53.
2002: Hitoshi Kiyoi; Tomoki Naoe
FLT3 in human hematologic malignancies.
Leukemia & lymphoma 2002;43(8):1541-7.
2002: Y Minami; Hitoshi Kiyoi; Y Yamamoto; Kazuhito Yamamoto; Ryuzo Ueda; Hidehiko Saito; Tomoki Naoe
Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors.
Leukemia 2002;16(8):1535-40.
2002: Hitoshi Kiyoi; Ryuzo Ohno; Ryuzo Ueda; Hidehiko Saito; Tomoki Naoe
Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain.
Oncogene 2002;21(16):2555-63.
2002: Tomoki Naoe; Y Tagawa; Hitoshi Kiyoi; Yoshihisa Kodera; Shuichi Miyawaki; Norio Asou; Kazutaka Kuriyama; S Kusumoto; Chihiro Shimazaki; K Saito; Hideki Akiyama; Toshiko Motoji; M Nishimura; Katsuji Shinagawa; Ryuzo Ueda; Hidehiko Saito; Ryuzo Ohno
Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy.
Leukemia 2002;16(2):203-8.
2001: Y Hirose; Hitoshi Kiyoi; K Itoh; K Kato; Hidehiko Saito; Tomoki Naoe
B-cell precursors differentiated from cord blood CD34+ cells are more immature than those derived from granulocyte colony-stimulating factor-mobilized peripheral blood CD34+ cells.
Immunology 2001;104(4):410-7.
2001: C Kato; Tomoki Naoe
[Genetic diagnosis of chronic myeloid leukemia].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(12):2336-41.
2001: Tomoki Naoe
Mechanism-based therapy for leukemia: a lesson from ATRA therapy.
Nagoya journal of medical science 2001;64(3-4):103-8.
2001: Tomoki Naoe; H Kiyoe; Y Yamamoto; Y Minami; Kazuhito Yamamoto; Ryuzo Ueda; Hidehiko Saito
FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy.
Cancer chemotherapy and pharmacology 2001;48 Suppl 1():S27-30.
2001: Hiroshi Kosugi; M Ito; Y Yamamoto; Masayuki Towatari; Masafumi Ito; Ryuzo Ueda; Hidehiko Saito; Tomoki Naoe
In vivo effects of a histone deacetylase inhibitor, FK228, on human acute promyelocytic leukemia in NOD / Shi-scid/scid mice.
Japanese journal of cancer research : Gann 2001;92(5):529-36.
2001: Y Yamamoto; Hitoshi Kiyoi; Y Nakano; Ritsuro Suzuki; Yoshihisa Kodera; Shuichi Miyawaki; Norio Asou; Kazutaka Kuriyama; Fumiharu Yagasaki; Chihiro Shimazaki; Hideki Akiyama; K Saito; Masahiko Nishimura; Toshiko Motoji; Katsuji Shinagawa; Akihiro Takeshita; Hidehiko Saito; Ryuzo Ueda; Ryuzo Ohno; Tomoki Naoe
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
Blood 2001;97(8):2434-9.
2001: Tomoki Naoe
[Molecule targeted therapy for hematological malignancies].
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(2):131-4.
2001: Hitoshi Kiyoi; Tomoki Naoe
Immunoglobulin variable region structure and B-cell malignancies.
International journal of hematology 2001;73(1):47-53.
2000: M Murata; Masayuki Towatari; Hiroshi Kosugi; Mitsune Tanimoto; Ryuzo Ueda; Hidehiko Saito; Tomoki Naoe
Apoptotic cytotoxic effects of a histone deacetylase inhibitor, FK228, on malignant lymphoid cells.
Japanese journal of cancer research : Gann 2000;91(11):1154-60.
2000: Tomoki Naoe; K Takeyama; T Yokozawa; Hitoshi Kiyoi; M Seto; Naokuni Uike; T Ino; A Utsunomiya; Atsuo Maruta; I Jin-nai; N Kamada; Y Kubota; H Nakamura; C Shimazaki; S Horiike; Yasuhiro Kodera; H Saito; R Ueda; J Wiemels; R Ohno
Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(10):4091-5.
2000: Kunio Kitamura; Y Minami; Kazuhito Yamamoto; Y Akao; Hitoshi Kiyoi; Hidehiko Saito; Tomoki Naoe
Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis.
Leukemia 2000;14(10):1743-50.
2000: Y Nakano; Tomoki Naoe; Hitoshi Kiyoi; K Kitamura; S Minami; Shuichi Miyawaki; Norio Asou; Kazutaka Kuriyama; S Kusumoto; Chihiro Shimazaki; Hideki Akiyama; K Saito; M Nishimura; Toshiko Motoji; Katsuji Shinagawa; Hidehiko Saito; Ryuzo Ohno
Prognostic value of p53 gene mutations and the product expression in de novo acute myeloid leukemia.
European journal of haematology 2000;65(1):23-31.
2000: Tomoki Naoe; Y Nakano; Hitoshi Kiyoi
Leukemia relapse reconsidered from the molecular aspect.
Leukemia & lymphoma 2000;37(5-6):527-34.
2000: Y Nakano; Tomoki Naoe; Hitoshi Kiyoi; S Kunishima; S Minami; Shuichi Miyawaki; Norio Asou; K Kuriyama; Hidehiko Saito; Ryuzo Ohno
Poor clinical significance of p53 gene polymorphism in acute myeloid leukemia.
Leukemia research 2000;24(4):349-52.
2000: Kunio Kitamura; S Hoshi; M Koike; Hitoshi Kiyoi; Hidehiko Saito; Tomoki Naoe
Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid.
British journal of haematology 2000;108(4):696-702.
2000: M Zhao; Hitoshi Kiyoi; Y Yamamoto; M Ito; Masayuki Towatari; S Omura; T Kitamura; Ryuzo Ueda; Hidehiko Saito; Tomoki Naoe
In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor.
Leukemia 2000;14(3):374-8.
2000: Fumihiko Hayakawa; Masayuki Towatari; Hitoshi Kiyoi; Mitsune Tanimoto; T Kitamura; Hidehiko Saito; Tomoki Naoe
Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines.
Oncogene 2000;19(5):624-31.
2000: T Yokozawa; Masayuki Towatari; H Iida; Kunihiko Takeyama; Mitsune Tanimoto; Hitoshi Kiyoi; Toshiko Motoji; Norio Asou; K Saito; M Takeuchi; Y Kobayashi; Shuichi Miyawaki; Yoshihisa Kodera; Ryuzo Ohno; Hidehiko Saito; Tomoki Naoe
Prognostic significance of the cell cycle inhibitor p27Kip1 in acute myeloid leukemia.
Leukemia 2000;14(1):28-33.
1999: Y Nakano; Tomoki Naoe
[Chromosome abnormalities and their clinical significance in leukemia and lymphoma].
Nihon rinsho. Japanese journal of clinical medicine 1999;57 Suppl():638-41.
1999: Shuichi Mizuta; Y Ito; Akio Kohno; Hitoshi Kiyoi; Koichi Miyamura; Mitsune Tanimoto; J Takamatsu; Tomoki Naoe; Yasuo Morishima; R Ueda; Hidehiko Saito
Accurate quantitation of residual tumor burden at bone marrow harvest predicts timing of subsequent relapse in patients with common ALL treated by autologous bone marrow transplantation. Nagoya BMT Group.
Bone marrow transplantation 1999;24(7):777-84.
1999: Hiroshi Kosugi; Masayuki Towatari; Sonoko Hatano; Kunio Kitamura; Hitoshi Kiyoi; Tomohiro Kinoshita; Mitsune Tanimoto; Takashi Murate; K Kawashima; Hidehiko Saito; Tomoki Naoe
Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy.
Leukemia 1999;13(9):1316-24.
1999: Shuichi Miyawaki; T Kobayashi; M Tanimoto; Kazutaka Kuriyama; H Murakami; M Yoshida; S Minami; K Minato; K Tsubaki; E Omoto; H Oh; Itsuro Jinnai; H Sakamaki; A Hiraoka; A Kanamaru; I Takahashi; K Saito; Tomoki Naoe; O Yamada; Norio Asou; S Kageyama; Nobuhiko Emi; T Ueda; M Tomonaga; Ryuzo Ohno
Comparison of leukopenia between cytarabine and behenoyl cytarabine in JALSG AML-89 consolidation therapy. The Japan Adult Leukemia Study Group.
International journal of hematology 1999;70(1):56-7.
1999: Hitoshi Kiyoi; Tomoki Naoe; Y Nakano; S Yokota; S Minami; Shuichi Miyawaki; Norio Asou; Kazutaka Kuriyama; Itsuro Jinnai; Chihiro Shimazaki; Hideki Akiyama; K Saito; H Oh; Toshiko Motoji; E Omoto; Hidehiko Saito; Ryuzo Ohno; Ryuzo Ueda
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia.
Blood 1999;93(9):3074-80.
1999: M Iida; Masayuki Towatari; A Nakao; H Iida; Hitoshi Kiyoi; Y Nakano; Mitsune Tanimoto; Hidehiko Saito; Tomoki Naoe
Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation.
Leukemia 1999;13(4):585-9.
1999: Y Nakano; Hitoshi Kiyoi; Shuichi Miyawaki; Norio Asou; Ryuzo Ohno; Hidehiko Saito; Tomoki Naoe
Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene.
British journal of haematology 1999;104(4):659-64.
1998: Mitsune Tanimoto; Shuichi Miyawaki; T Ino; Taiichi Kyo; Hisashi Sakamaki; Tomoki Naoe; Akira Hiraoka; Norio Asou; T Ohshima; K Tsubaki; Kazutaka Kuriyama; T Ueda; S Minamil; K Okabe; Hidehiko Saito; H Murakami; M Hirano; Hiroo Dohy; Y Onozawa; H Suzuki; Ryuzo Ohno
Response-oriented individualized induction therapy followed by intensive consolidation and maintenance for adult patients with acute lymphoblastic leukemia: the ALL-87 study of the Japan Adult Leukemia Study Group (JALSG).
International journal of hematology 1998;68(4):421-9.
1998: Hitoshi Kiyoi; Masayuki Towatari; S Yokota; M Hamaguchi; Ryuzo Ohno; Hidehiko Saito; Tomoki Naoe
Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product.
Leukemia 1998;12(9):1333-7.
1998: Kazuko Kudo; H Yoshida; Hitoshi Kiyoi; Shin-ichiro Numata; Keizo Horibe; Tomoki Naoe
Etoposide-related acute promyelocytic leukemia.
Leukemia 1998;12(8):1171-5.
1998: Fumihiko Hayakawa; Masayuki Towatari; H Iida; H Wakao; Hitoshi Kiyoi; Tomoki Naoe; Hidehiko Saito
Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia.
British journal of haematology 1998;101(3):521-8.
1998: Y Takahashi; Keizo Horibe; Hitoshi Kiyoi; Y Miyashita; M Fukuda; H Mori; C Nozaki; S Hasegawa; T Kawabe; Kanefusa Kato; Seiji Kojima; T Matuyama; Tomoki Naoe
Prognostic significance of TEL/AML1 fusion transcript in childhood B-precursor acute lymphoblastic leukemia.
Journal of pediatric hematology/oncology 1998;20(3):190-5.
1998: Hitoshi Kiyoi; K Naito; Ryuzo Ohno; Hidehiko Saito; Tomoki Naoe
Characterization of the immunoglobulin light chain variable region gene expressed in multiple myeloma.
Leukemia 1998;12(4):601-9.
1998: H Yoshida; M Kondo; T Ichihashi; N Hashimoto; J Inazawa; Ryuzo Ohno; Tomoki Naoe
A novel myeloid cell line, Marimo, derived from therapy-related acute myeloid leukemia during treatment of essential thrombocythemia: consistent chromosomal abnormalities and temporary C-MYC gene amplification.
Cancer genetics and cytogenetics 1998;100(1):21-4.
1997: Kunio Kitamura; Hitoshi Kiyoi; H Yoshida; Hidehiko Saito; Ryuzo Ohno; Tomoki Naoe
Mutant AF-2 domain of PML-RARalpha in retinoic acid-resistant NB4 cells: differentiation induced by RA is triggered directly through PML-RARalpha and its down-regulation in acute promyelocytic leukemia.
Leukemia 1997;11(11):1950-6.
1997: Hitoshi Kiyoi; Tomoki Naoe; S Yokota; M Nakao; S Minami; Kazutaka Kuriyama; Akihiro Takeshita; K Saito; S Hasegawa; S Shimodaira; J Tamura; Chihiro Shimazaki; K Matsue; H Kobayashi; N Arima; Ritsuro Suzuki; H Morishita; Hidehiko Saito; Ryuzo Ueda; Ryuzo Ohno
Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho).
Leukemia 1997;11(9):1447-52.
1997: H Mori; Hitoshi Kiyoi; Keizo Horibe; Ryuzo Ohno; Tomoki Naoe
Comparison of the immunoglobulin gene transcripts between immature B lineage acute lymphoblastic leukemia and the normal phenotypic counterparts in the bone marrow.
Leukemia 1997;11(8):1274-80.
1997: K Yamanaka; K Kubo; Hitoshi Kiyoi; T Ichihashi; Kanefusa Kato; Keizo Horibe; Tomoki Naoe
Unusual feature of the T-cell receptor genes in T-lineage acute lymphoblastic leukemia.
Leukemia research 1997;21(7):667-74.
1997: Tomoki Naoe; Kazuko Kudo; H Yoshida; Keizo Horibe; Ryuzo Ohno
Molecular analysis of the t(15;17) translocation in de novo and secondary acute promyelocytic leukemia.
Leukemia 1997;11 Suppl 3():287-8.
1997: Shinji Kunishima; Jose A Lopez; S Kobayashi; N Imai; T Kamiya; Hidehiko Saito; Tomoki Naoe
Missense mutations of the glycoprotein (GP) Ib beta gene impairing the GPIb alpha/beta disulfide linkage in a family with giant platelet disorder.
Blood 1997;89(7):2404-12.
1997: Kunio Kitamura; H Yoshida; Ryuzo Ohno; Tomoki Naoe
Toxic effects of arsenic (As3+) and other metal ions on acute promyelocytic leukemia cells.
International journal of hematology 1997;65(2):179-85.
1997: Kunio Kitamura; Hitoshi Kiyoi; H Yoshida; T Tobita; Akihiro Takeshita; Ryuzo Ohno; Tomoki Naoe
New retinoids and arsenic compounds for the treatment of refractory acute promyelocytic leukemia: clinical and basic studies for the next generation.
Cancer chemotherapy and pharmacology 1997;40 Suppl():S36-41.
1996: Hitoshi Kiyoi; H Mori; Keizo Horibe; R Ohno; Tomoki Naoe
Comparison of the immunoglobulin heavy-chain complementarity determining region-3 structure among the DNA sequences and the mu- and gamma-transcripts in human B-lineage cells.
Immunology 1996;89(3):324-30.
1996: Hitoshi Kiyoi; K Naito; R Ohno; Tomoki Naoe
Comparable gene structure of the immunoglobulin heavy chain variable region between multiple myeloma and normal bone marrow lymphocytes.
Leukemia 1996;10(11):1804-12.
1996: S Kunishima; T Tahara; T Kato; S Kobayashi; H Saito; Tomoki Naoe
Serum thrombopoietin and plasma glycocalicin concentrations as useful diagnostic markers in thrombocytopenic disorders.
European journal of haematology 1996;57(1):68-71.
1996: H Yoshida; Kunio Kitamura; K Tanaka; S Omura; T Miyazaki; T Hachiya; R Ohno; Tomoki Naoe
Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway.
Cancer research 1996;56(13):2945-8.
1996: K Kubo; K Yamanaka; Hitoshi Kiyoi; H Fukutani; M Ito; R Hayakawa; R Ohno; Tomoki Naoe
Different T-cell receptor repertoires between lesions and peripheral blood in acute graft-versus-host disease after allogeneic bone marrow transplantation.
Blood 1996;87(7):3019-26.
1996: S Kunishima; S Kobayashi; Tomoki Naoe
Increased but highly dispersed levels of plasma glycocalicin in patients with disseminated intravascular coagulation.
European journal of haematology 1996;56(3):173-7.
1995: Hitoshi Kiyoi; Seiji Kojima; K Kato; Takaharu Matsuyama; Yoshihisa Kodera; R Ohno; Tomoki Naoe
Detection of minimal residual disease in patients with childhood common acute lymphoblastic leukemia after autologous bone marrow transplantation with ex vivo purging and systemic IL-2 infusion: unsuccessful prediction of subsequent relapse.
Bone marrow transplantation 1995;16(3):437-42.
1995: H Fukutani; Tomoki Naoe; R Ohno; H Yoshida; Shuichi Miyawaki; Chihiro Shimazaki; T Miyake; Y Nakayama; H Kobayashi; S Goto
Isoforms of PML-retinoic acid receptor alpha fused transcripts affect neither clinical features of acute promyelocytic leukemia nor prognosis after treatment with all-trans retinoic acid. The Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho).
Leukemia 1995;9(9):1478-82.
1995: Hitoshi Kiyoi; K Naito; R Ohno; Tomoki Naoe
Comparable profiles of the immunoglobulin heavy chain complementarity determining region (CDR)-3 in CD5+ and CD5- human cord blood B lymphocytes.
Immunology 1995;85(2):236-40.
1995: H Fukutani; Tomoki Naoe; R Ohno; H Yoshida; Hitoshi Kiyoi; Shuichi Miyawaki; H Morishita; F Sano; H Kamibayashi; K Matsue
Prognostic significance of the RT-PCR assay of PML-RARA transcripts in acute promyelocytic leukemia. The Leukemia Study Group of the Ministry of Health and Welfare (Kouseisho).
Leukemia 1995;9(4):588-93.
1995: Hitoshi Kiyoi; Tomoki Naoe; R Ohno
[Characterization of the immunoglobulin heavy and light chain variable region sequences from human multiple myeloma cells].
Nihon rinsho. Japanese journal of clinical medicine 1995;53(3):592-7.
1995: Hitoshi Kiyoi; H Fukutani; T Yamauchi; K Kubo; R Ohno; S Yamamori; Tomoki Naoe
Continuing immunoglobulin heavy chain gene rearrangements in chronic myeloid leukemia with recurrent B-lymphoid blast crises after bone marrow transplantation.
Leukemia 1995;9(2):265-70.
1995: H Yoshida; Tomoki Naoe; H Fukutani; Hitoshi Kiyoi; K Kubo; R Ohno
Analysis of the joining sequences of the t(15;17) translocation in human acute promyelocytic leukemia: sequence non-specific recombination between the PML and RARA genes within identical short stretches.
Genes, chromosomes & cancer 1995;12(1):37-44.
1994: Hitoshi Kiyoi; H Fukutani; K Kubo; R Ohno; Tomoki Naoe
Characterization of immunoglobulin heavy chain gene rearrangements in chronic myeloid leukemia with recurrent B-lymphoid blast crisis following bone marrow transplantation.
Internal medicine (Tokyo, Japan) 1994;33(12):786-9.
1994: S Kunishima; H Miura; H Fukutani; H Yoshida; K Osumi; S Kobayashi; R Ohno; Tomoki Naoe
Bernard-Soulier syndrome Kagoshima: Ser 444-->stop mutation of glycoprotein (GP) Ib alpha resulting in circulating truncated GPIb alpha and surface expression of GPIb beta and GPIX.
Blood 1994;84(10):3356-62.
1994: R Ohno; Tomoki Naoe; A Kanamaru; M Yoshida; A Hiraoka; T Kobayashi; T Ueda; S Minami; Y Morishima; Y Saito
A double-blind controlled study of granulocyte colony-stimulating factor started two days before induction chemotherapy in refractory acute myeloid leukemia. Kohseisho Leukemia Study Group.
Blood 1994;83(8):2086-92.
1994: K Kubo; Tomoki Naoe; H Fukutani; R Ohno
[New strategy for diagnosis and treatment of acute promyelocytic leukemia with t (15;17)].
[Rinshō ketsueki] The Japanese journal of clinical hematology 1994;35(3):250-5.
1993: R Ohno; H Yoshida; H Fukutani; Tomoki Naoe; T Ohshima; Taiichi Kyo; N Endoh; T Fujimoto; T Kobayashi; A Hiraoka
Multi-institutional study of all-trans-retinoic acid as a differentiation therapy of refractory acute promyelocytic leukemia. Leukaemia Study Group of the Ministry of Health and Welfare.
Leukemia 1993;7(11):1722-7.
1993: A Matsuoka; K Miyamura; Nobuhiko Emi; T Tahara; Mitsune Tanimoto; Tomoki Naoe; R Ohno; A Kakizuka; R M Evans; H Saito
Unexpected heterogeneity of PML/RAR alpha fused mRNA detected by nested polymerase chain reaction in acute promyelocytic leukemia.
Leukemia 1993;7(8):1151-5.
1993: Hitoshi Kiyoi; Tomoki Naoe; T Yamauchi; H Fukatani; K Kubo; Seiji Kojima; R Ohno
Minimal residual disease status in pre-B acute lymphoblastic leukemia patients after chemotherapy and bone marrow transplantation: assessment of the anti-leukemic effects of chemotherapy and BMT.
Leukemia research 1993;17(8):677-84.
1993: T Ichihashi; K Kubo; Tomoki Naoe; R Ohno
Nucleotide sequences of the variable regions of a human monoclonal antibody against HLA-A1, A23, and A24.
Tissue antigens 1993;41(5):249-54.
1993: K Kubo; Tomoki Naoe; Hitoshi Kiyoi; H Fukutani; Y Kato; T Oguri; S Yamamori; Yoshiki Akatsuka; Yoshihisa Kodera; R Ohno
Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia.
Japanese journal of cancer research : Gann 1993;84(4):379-87.
1993: R Ohno; Tomoki Naoe; M Hirano; M Kobayashi; H Hirai; K Tubaki; H Oh
Treatment of myelodysplastic syndromes with all-trans retinoic acid. Leukemia Study Group of the Ministry of Health and Welfare.
Blood 1993;81(5):1152-4.
1993: H Fukutani; Tomoki Naoe; H Yoshida; S Yamamori; R Ohno
Molecular heterogeneity of the PML gene rearrangement in acute promyelocytic leukemia: prevalence and clinical significance.
Japanese journal of cancer research : Gann 1993;84(3):257-64.
1992: T Ichihashi; H Yoshida; Hitoshi Kiyoi; H Fukutani; K Kubo; T Yamauchi; Tomoki Naoe; R Ohno
Development of hyperthyroidism in donor and recipient after allogeneic bone marrow transplantation.
Bone marrow transplantation 1992;10(4):397-8.
1992: Haruhiko Ohashi; A Ichikawa; N Takagi; Tomomitsu Hotta; Tomoki Naoe; R Ohno; H Saito
Remission induction of acute promyelocytic leukemia by all-trans-retinoic acid: molecular evidence of restoration of normal hematopoiesis after differentiation and subsequent extinction of leukemic clone.
Leukemia 1992;6(8):859-62.
1992: Hitoshi Kiyoi; Tomoki Naoe; Keizo Horibe; R Ohno
Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells.
The Journal of clinical investigation 1992;89(3):739-46.
1992: T Ichihashi; Hitoshi Kiyoi; H Fukutani; K Kubo; T Yamauchi; Tomoki Naoe; K Yamada; R Ohno
Effective treatment of adult T cell leukemia/lymphoma with a novel oral antitumor agent, MST-16.
Oncology 1992;49(5):333-5.
1991: H Fukutani; Tomoki Naoe; H Saito; T Ohshima; M Omine; Y Miura; H Mizoguchi; I Kimura; M Tomonaga; R Ohno
Treatment of myelodysplastic syndromes with orally administered N-(2S, 3R)-3-amino-2-hydroxy-4-phenylbutyryl-L-leucine (ubenimex).
Japanese journal of clinical oncology 1991;21(4):287-92.
1991: Hitoshi Kiyoi; Tomoki Naoe; K Kitamura; T Yamauchi; T Ichihashi; R Ohno
Disappearance of minimal residual lymphoblastic leukemia cells 6 months after allogeneic bone marrow transplantation without GVHD.
Bone marrow transplantation 1991;8(1):59-62.
1991: H Fukutani; Tomoki Naoe; R Ohno
[Is allogeneic bone marrow transplantation the first choice for acute leukemia in first remission? From chemotherapeutical point of view].
[Rinshō ketsueki] The Japanese journal of clinical hematology 1991;32(4):361-5.
1990: Tomoki Naoe
[c-myc gene].
Nihon rinsho. Japanese journal of clinical medicine 1990;48(8):35-40.
1990: T Yamauchi; Tomoki Naoe; Y Kurosawa; H Shiku; K Yamada
Autoantibodies to c-myc nuclear protein products in autoimmune disease.
Immunology 1990;69(1):117-20.
1989: Tomoki Naoe; Hitoshi Kiyoi; K Yamanaka; K Naito; K Yamada
A case of cALL relapse after allogeneic BMT: recurrence of recipient cell origin, initially determined as being that of donor cell origin by sex chromosome analysis.
British journal of haematology 1989;73(3):420-2.
1989: Tomoki Naoe; N Nozaki; K Yamada; Tuneko Okazaki; E Nakayama; Y Kurosawa; H Shiku
Diversity of cellular molecules in human cells detected by monoclonal antibodies reactive with c-myc proteins produced in Escherichia coli.
Japanese journal of cancer research : Gann 1989;80(8):747-53.
1989: T Kinouchi; S Saiki; Tomoki Naoe; A Uenaka; T Kotake; H Shiku; E Nakayama
Correlation of c-myc expression with nuclear pleomorphism in human renal cell carcinoma.
Cancer research 1989;49(13):3627-30.
1988: Tomoki Naoe; Y Akao; K Yamada; K R Utsumi; K Koike; M Shamoto; K Koie; Y Kurosawa; K Kato; M Abe
Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells.
Cancer genetics and cytogenetics 1988;34(1):77-88.