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Diwahar Narasimhan

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Gregory Collins; Remy L Brim; Nicholas W Lukacs; Diwahar Narasimhan; Kathleen R Noon; Roger K Sunahara; James H Woods; Mei-Chuan Ko
Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.
Gregory Collins; Alyssa R Cunningham; Mei-Chuan Ko; Diwahar Narasimhan; Joseph Nichols; Roger K Sunahara; Matthew E Zaks; James H Woods
Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.
Diwahar Narasimhan; James H Woods; Roger K Sunahara
Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction.

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2012: Gregory Collins; Remy L Brim; Nicholas W Lukacs; Diwahar Narasimhan; Kathleen R Noon; Roger K Sunahara; James H Woods; Mei-Chuan Ko
Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 2012;342(1):205-13.
2012: Gregory Collins; Alyssa R Cunningham; Mei-Chuan Ko; Diwahar Narasimhan; Joseph Nichols; Roger K Sunahara; Matthew E Zaks; James H Woods
Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(5):1092-103.
2012: Diwahar Narasimhan; James H Woods; Roger K Sunahara
Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction.
Future medicinal chemistry 2012;4(2):137-50.
2011: Remy L Brim; Diwahar Narasimhan; Joseph Nichols; Kathleen R Noon; James H Woods; Roger K Sunahara
Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs.
Drug and alcohol dependence 2011;119(3):224-8.
2011: Diwahar Narasimhan; Joseph Nichols; John J G Tesmer; James H Woods; Jimmy Chan; Gregory Collins; Elin Edwald; Mei-Chuan Ko; Mark R Nance; Roger K Sunahara
Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Molecular pharmacology 2011;80(6):1056-65.
2011: Remy L Brim; Gregory Collins; Diwahar Narasimhan; Joseph Nichols; Kathleen R Noon; Roger K Sunahara; James H Woods
The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry.
Molecular pharmacology 2011;80(6):1119-27.
2011: Gregory Collins; Alyssa R Cunningham; Mei-Chuan Ko; Diwahar Narasimhan; Joseph Nichols; Carley St Clair; Roger K Sunahara; Matthew E Zaks; James H Woods
Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.
Drug and alcohol dependence 2011;118(2-3):158-65.
2011: Gregory T Collins; Kathy A Carey; Diwahar Narasimhan; Joseph Nichols; Aaron A Berlin; Nicholas W Lukacs; Roger K Sunahara; James H Woods; Mei-Chuan Ko
Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011;36(5):1047-59.
2010: Diwahar Narasimhan; Mark R Nance; Daquan Gao; Mei-Chuan Ko; Joanne Macdonald; Patricia Tamburi; Dan Yoon; Donald M Landry; James H Woods; Chang-Guo Zhan; John J G Tesmer; Roger K Sunahara
Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein engineering, design & selection : PEDS 2010;23(7):537-47.
2010: Remy L Brim; Mark R Nance; Daniel W Youngstrom; Diwahar Narasimhan; Chang-Guo Zhan; John J G Tesmer; Roger K Sunahara; James H Woods
A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse.
Molecular pharmacology 2010;77(4):593-600.
2010: Susan K Wood; Diwahar Narasimhan; Ziva D Cooper; Roger K Sunahara; James H Woods
Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats.
Drug and alcohol dependence 2010;106(2-3):219-29.
2009: Gregory Collins; Remy L Brim; Diwahar Narasimhan; Mei-Chuan Ko; Roger K Sunahara; Chang-Guo Zhan; James H Woods
Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats.
The Journal of pharmacology and experimental therapeutics 2009;331(2):445-55.
2009: Emily Jutkiewicz; Michelle G Baladi; Ziva D Cooper; Diwahar Narasimhan; Roger K Sunahara; James H Woods
A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality.
Annals of emergency medicine 2009;54(3):409-20.
2009: Mei-Chuan Ko; Diwahar Narasimhan; Aaron A Berlin; Nicholas W Lukacs; Roger K Sunahara; James H Woods
Effects of cocaine esterase following its repeated administration with cocaine in mice.
Drug and alcohol dependence 2009;101(3):202-9.
2007: Mei-Chuan Ko; Luvina D Bowen; Diwahar Narasimhan; Aaron A Berlin; Nicholas W Lukacs; Roger K Sunahara; Ziva D Cooper; James H Woods
Cocaine esterase: interactions with cocaine and immune responses in mice.
The Journal of pharmacology and experimental therapeutics 2007;320(2):926-33.
2006: Ziva D Cooper; Diwahar Narasimhan; Roger K Sunahara; Pawel Mierzejewski; Emily Jutkiewicz; Nicholas A Larsen; Ian A Wilson; Donald W Landry; James H Woods
Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase.
Molecular pharmacology 2006;70(6):1885-91.
2002: Diwahar Narasimhan; Roy F Collaco; Vivian Kalman-Maltese; James P Trempe
Hyper-phosphorylation of the adeno-associated virus Rep78 protein inhibits terminal repeat binding and helicase activity.
Biochimica et biophysica acta 2002;1576(3):298-305.
1997: David Stafford-Johnson; Diwahar Narasimhan
Case report: successful treatment of bleeding jejunal varices using mesoportal recanalization and stent placement: report of a case and review of the literature.
Clinical radiology 1997;52(7):562-5.