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Purnima Narasimhan

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Nobuya Okami; Hiroyuki Sakata; Hideyuki Yoshioka; Joo Eun Jung; Gab Seok Kim; Carolina M Maier; Purnima Narasimhan; Pak H Chan
Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase.
Hiroyuki Sakata; Takuma Wakai; Carolina M Maier; Purnima Narasimhan; Kuniyasu Niizuma; Pak H Chan
Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice.
Chikako Nito; Hidenori Endo; Hiroshi Kamada; Yong-Sun Lee; Purnima Narasimhan; Pak H Chan
Involvement of mitogen-activated protein kinase pathways in expression of the water channel protein aquaporin-4 after ischemia in rat cortical astrocytes.

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2013: Nobuya Okami; Hiroyuki Sakata; Hideyuki Yoshioka; Joo Eun Jung; Gab Seok Kim; Carolina M Maier; Purnima Narasimhan; Pak H Chan
Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2013;33(1):106-14.
2012: Hiroyuki Sakata; Takuma Wakai; Carolina M Maier; Purnima Narasimhan; Kuniyasu Niizuma; Pak H Chan
Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice.
Brain : a journal of neurology 2012;135(Pt 11):3298-310.
2012: Chikako Nito; Hidenori Endo; Hiroshi Kamada; Yong-Sun Lee; Purnima Narasimhan; Pak H Chan
Involvement of mitogen-activated protein kinase pathways in expression of the water channel protein aquaporin-4 after ischemia in rat cortical astrocytes.
Journal of neurotrauma 2012;29(14):2404-12.
2012: Hiroyuki Sakata; Takuma Wakai; Carolina M Maier; Purnima Narasimhan; Kuniyasu Niizuma; Pak H Chan
Neural stem cells genetically modified to overexpress cu/zn-superoxide dismutase enhance amelioration of ischemic stroke in mice.
Stroke; a journal of cerebral circulation 2012;43(9):2423-9.
2012: Gab Seok Kim; Purnima Narasimhan; Nobuya Okami; Hiroyuki Sakata; Yun Seon Song; Hideyuki Yoshioka; Joo Eun Jung; Pak H Chan
Release of mitochondrial apoptogenic factors and cell death are mediated by CK2 and NADPH oxidase.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012;32(4):720-30.
2012: Hiroyuki Sakata; Hideyuki Yoshioka; Joo Eun Jung; Masataka Katsu; Gab Seok Kim; Carolina M Maier; Purnima Narasimhan; Kuniyasu Niizuma; Yasuhiro Nishiyama; Pak H Chan
Minocycline-preconditioned neural stem cells enhance neuroprotection after ischemic stroke in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(10):3462-73.
2011: Hai Chen; Hideyuki Yoshioka; Gab Seok Kim; Joo Eun Jung; Nobuya Okami; Hiroyuki Sakata; Carolina M Maier; Purnima Narasimhan; Christina E Goeders; Pak H Chan
Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection.
Antioxidants & redox signaling 2011;14(8):1505-17.
2011: Hideyuki Yoshioka; Kuniyasu Niizuma; Masataka Katsu; Nobuya Okami; Hiroyuki Sakata; Gab Seok Kim; Purnima Narasimhan; Pak H Chan
NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(3):868-80.
2010: Joo Eun Jung; Gab Seok Kim; Hai Chen; Carolina M Maier; Purnima Narasimhan; Yun Seon Song; Kuniyasu Niizuma; Masataka Katsu; Nobuya Okami; Hideyuki Yoshioka; Hiroyuki Sakata; Christina E Goeders; Pak H Chan
Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection.
Molecular neurobiology 2010;41(2-3):172-9.
2009: Joo Eun Jung; Gab Seok Kim; Purnima Narasimhan; Yun Seon Song; Pak H Chan
Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(21):7003-14.
2009: Purnima Narasimhan; Jing Liu; Yun Seon Song; Justin L Massengale; Pak H Chan
VEGF Stimulates the ERK 1/2 signaling pathway and apoptosis in cerebral endothelial cells after ischemic conditions.
Stroke; a journal of cerebral circulation 2009;40(4):1467-73.
2008: Yun Seon Song; Purnima Narasimhan; Gab Seok Kim; Joo Eun Jung; Eun-Hee Park; Pak H Chan
The role of Akt signaling in oxidative stress mediates NF-kappaB activation in mild transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(12):1917-26.
2008: fengshan yu; Purnima Narasimhan; Atsushi Saito; Jing Liu; Pak H Chan
Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(1):44-52.
2007: Yun Seon Song; Yong-Sun Lee; Purnima Narasimhan; Pak H Chan
Reduced oxidative stress promotes NF-kappaB-mediated neuroprotective gene expression after transient focal cerebral ischemia: lymphocytotrophic cytokines and antiapoptotic factors.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(4):764-75.
2006: Carolina M Maier; Lily Hsieh; T Crandall; Purnima Narasimhan; Pak H Chan
A new approach for the investigation of reperfusion-related brain injury.
Biochemical Society transactions 2006;34(Pt 6):1366-9.
2006: Carolina M Maier; Lily Hsieh; Trisha Crandall; Purnima Narasimhan; Pak H Chan
Evaluating therapeutic targets for reperfusion-related brain hemorrhage.
Annals of neurology 2006;59(6):929-38.
2006: Jing Liu; Purnima Narasimhan; Yong-Sun Lee; Yun Seon Song; Hidenori Endo; fengshan yu; Pak H Chan
Mild hypoxia promotes survival and proliferation of SOD2-deficient astrocytes via c-Myc activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(16):4329-37.
2006: Jing Liu; Purnima Narasimhan; Yun Seon Song; Tatsuro Nishi; fengshan yu; Yong-Sun Lee; Pak H Chan
Epo protects SOD2-deficient mouse astrocytes from damage by oxidative stress.
Glia 2006;53(4):360-5.
2005: Jing Liu; Purnima Narasimhan; fengshan yu; Pak H Chan
Neuroprotection by hypoxic preconditioning involves oxidative stress-mediated expression of hypoxia-inducible factor and erythropoietin.
Stroke; a journal of cerebral circulation 2005;36(6):1264-9.
2005: Purnima Narasimhan; Taku Sugawara; Jing Liu; Takeshi Hayashi; Nobuo Noshita; Pak H Chan
Overexpression of human copper/zinc-superoxide dismutase in transgenic animals attenuates the reduction of apurinic/apyrimidinic endonuclease expression in neurons after in vitro ischemia and after transient global cerebral ischemia.
Journal of neurochemistry 2005;93(2):351-8.
2005: Atsushi Saito; Carolina M Maier; Purnima Narasimhan; Tatsuro Nishi; Yun Seon Song; fengshan yu; Jing Liu; Yong-Sun Lee; Chikako Nito; Hiroshi Kamada; Robert L Dodd; Lily B Hsieh; Benjamin Hassid; Esther E Kim; Maricela González; Pak H Chan
Oxidative stress and neuronal death/survival signaling in cerebral ischemia.
Molecular neurobiology 2005;31(1-3):105-16.
2004: Atsushi Saito; Purnima Narasimhan; Takeshi Hayashi; Shuzo Okuno; Michel Ferrand-Drake; Pak H Chan
Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(7):1584-93.
2004: Taku Sugawara; Miki Fujimura; Nobuo Noshita; Gyung W Kim; Atsushi Saito; Takeshi Hayashi; Purnima Narasimhan; Carolina M Maier; Pak H Chan
Neuronal death/survival signaling pathways in cerebral ischemia.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2004;1(1):17-25.
2003: Purnima Narasimhan; Miki Fujimura; Nobuo Noshita; Pak H Chan
Role of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia.
Brain research. Molecular brain research 2003;113(1-2):28-36.