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Michiko Narazaki

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Toru Hirano; Satoshi Hohki; Tadamitsu Kishimoto; Atsushi Kumanogoh; Michiko Narazaki; Atsushi Ogata; Nobuyuki Ohguro; Yoshihito Shima; Keisuke Hagihara; Kazuyuki Yoshizaki; Toshio Tanaka
A case of Behçet's disease treated with a humanized anti-interleukin-6 receptor antibody, tocilizumab.
Toshio Tanaka; Michiko Narazaki; Tadamitsu Kishimoto
Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases.
Sumiyuki Nishida; Atsushi Ogata; Yoshihiro Oka; Yoshihito Shima; Keisuke Hagihara; Toru Hirano; Yoshihiro Hishitani; Taeko Ishii; Hirokazu Kashiwagi; Mari Kawai; Tomio Kawasaki; Tadamitsu Kishimoto; Atsuyoshi Morishima; Michiko Narazaki; Toshio Tanaka
Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab.

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All Publications

2012: Toru Hirano; Satoshi Hohki; Tadamitsu Kishimoto; Atsushi Kumanogoh; Michiko Narazaki; Atsushi Ogata; Nobuyuki Ohguro; Yoshihito Shima; Keisuke Hagihara; Kazuyuki Yoshizaki; Toshio Tanaka
A case of Behçet's disease treated with a humanized anti-interleukin-6 receptor antibody, tocilizumab.
Modern rheumatology / the Japan Rheumatism Association 2012;22(2):298-302.
2011: Toshio Tanaka; Michiko Narazaki; Tadamitsu Kishimoto
Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases.
FEBS letters 2011;585(23):3699-709.
2011: Sumiyuki Nishida; Atsushi Ogata; Yoshihiro Oka; Yoshihito Shima; Keisuke Hagihara; Toru Hirano; Yoshihiro Hishitani; Taeko Ishii; Hirokazu Kashiwagi; Mari Kawai; Tomio Kawasaki; Tadamitsu Kishimoto; Atsuyoshi Morishima; Michiko Narazaki; Toshio Tanaka
Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab.
Modern rheumatology / the Japan Rheumatism Association 2011;21(4):420-2.
2011: Michiko Narazaki; Atsushi Ogata; Yoshihito Shima; Keisuke Hagihara; Tadamitsu Kishimoto; Toshio Tanaka
Therapeutic effect of tocilizumab on two patients with polymyositis.
Rheumatology (Oxford, England) 2011;50(7):1344-6.
2011: Atsushi Ogata; Atsuyoshi Morishima; Toru Hirano; Yoshihiro Hishitani; Keisuke Hagihara; Yoshihito Shima; Michiko Narazaki; Toshio Tanaka
Improvement of HbA1c during treatment with humanised anti-interleukin 6 receptor antibody, tocilizumab.
Annals of the rheumatic diseases 2011;70(6):1164-5.
2011: Michiko Narazaki; Tetsuya Wakayama; Hirohiko Imai; Atsuomi Kimura; Hideaki Fujiwara
Origin of dissolved-phase hyperpolarized 129Xe signal in the mouse chest based on experimental evidence from extensive magnetic resonance measurements.
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2011;10(3):149-54.
2010: Yoshihito Shima; Yusuke Kuwahara; Hiroyuki Murota; Shun Kitaba; Mari Kawai; Toru Hirano; Junsuke Arimitsu; Michiko Narazaki; Keisuke Hagihara; Atsushi Ogata; Ichiro Katayama; Ichiro Kawase; Tadamitsu Kishimoto; Toshio Tanaka
The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab.
Rheumatology (Oxford, England) 2010;49(12):2408-12.
2010: Toshio Tanaka; Atsushi Ogata; Michiko Narazaki
Tocilizumab for the treatment of rheumatoid arthritis.
Expert review of clinical immunology 2010;6(6):843-54.
2009: Toshio Tanaka; Yusuke Kuwahara; Yoshihito Shima; Toru Hirano; Mari Kawai; Masako Ogawa; Junsuke Arimitsu; Keisuke Hagihara; Michiko Narazaki; Atsushi Ogata; Ichiro Kawase; Tadamitsu Kishimoto
Successful treatment of reactive arthritis with a humanized anti-interleukin-6 receptor antibody, tocilizumab.
Arthritis and rheumatism 2009;61(12):1762-4.
2008: Tetsuya Wakayama; Masakazu Kitamoto; Tsuyoshi Ueyama; Hirohiko Imai; Michiko Narazaki; Atsuomi Kimura; Hideaki Fujiwara
Hyperpolarized 129 Xe MRI of the mouse lung at a low xenon concentration using a continuous flow-type hyperpolarizing system.
Journal of magnetic resonance imaging : JMRI 2008;27(4):777-84.
2008: Tetsuya Wakayama; Michiko Narazaki; Atsuomi Kimura; Hideaki Fujiwara
Hyperpolarized 129Xe phase-selective imaging of mouse lung at 9.4T using a continuous-flow hyperpolarizing system.
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2008;7(2):65-72.
2006: Michiko Narazaki; Tetsuya Wakayama; Hirohiko Imai; Atsuomi Kimura; Hideaki Fujiwara
Analysis of hyperpolarized 129Xe dynamics in mouse lungs under spontaneous respiration for separate determination of lung functional parameters and relaxation time.
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2006;5(3):119-28.
2006: Hirohiko Imai; Michiko Narazaki; Hiroyuki Inoshita; Atsuomi Kimura; Hideaki Fujiwara
MR imaging of mouse lung using hyperpolarized 3He: image acquisition and T1 estimation under spontaneous respiration.
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2006;5(2):57-64.
2004: Atsuomi Kimura; Michiko Narazaki; Yoko Kanazawa; Hideaki Fujiwara
19F Magnetic resonance imaging of perfluorooctanoic acid encapsulated in liposome for biodistribution measurement.
Magnetic resonance imaging 2004;22(6):855-60.
2004: Atsuomi Kimura; Tetsuya Wakayama; Michiko Narazaki; Yoko Kawata; Tsuyoshi Ueyama; Hideaki Fujiwara
Improvement of T1 determination of hyperpolarized 129Xe in mouse brain under controlled-flow.
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2004;3(4):199-205.
2001: Tetsuji Naka; H Tsutsui; M Fujimoto; Y Kawazoe; H Kohzaki; Y Morita; Reiko Nakagawa; Michiko Narazaki; K Adachi; T Yoshimoto; K Nakanishi; T Kishimoto
SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo.
Immunity 2001;14(5):535-45.
2001: Y Kawazoe; Tetsuji Naka; Minoru Fujimoto; H Kohzaki; Y Morita; Michiko Narazaki; Koichi Okumura; H Saitoh; Reiko Nakagawa; Y Uchiyama; Shizuo Akira; Tadamitsu Kishimoto
Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation.
The Journal of experimental medicine 2001;193(2):263-9.
2000: Minoru Fujimoto; Tetsuji Naka; Reiko Nakagawa; Y Kawazoe; Y Morita; A Tateishi; Koichi Okumura; Michiko Narazaki; Tadamitsu Kishimoto
Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1799-806.
2000: Hiroshi Saito; Y Morita; Minoru Fujimoto; Michiko Narazaki; Tetsuji Naka; Tadamitsu Kishimoto
IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5833-43.
2000: Y Morita; Tetsuji Naka; Y Kawazoe; Minoru Fujimoto; Michiko Narazaki; Reiko Nakagawa; Hidenao Fukuyama; Shigekazu Nagata; Tadamitsu Kishimoto
Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5405-10.
1998: Tetsuji Naka; Takuya Matsumoto; Michiko Narazaki; Minoru Fujimoto; Y Morita; Y Ohsawa; Hiroshi Saito; Takashi Nagasawa; Y Uchiyama; Tadamitsu Kishimoto
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15577-82.
1998: Michiko Narazaki; Minoru Fujimoto; Takuya Matsumoto; Y Morita; Hiroshi Saito; T Kajita; Kazuyuki Yoshizaki; Tetsuji Naka; Tadamitsu Kishimoto
Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13130-4.
1997: S Minamoto; Kazuhiro Ikegame; K Ueno; Michiko Narazaki; Tetsuji Naka; Hirofumi Yamamoto; Takuya Matsumoto; Hiroshi Saito; S Hosoe; Tadamitsu Kishimoto
Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.
Biochemical and biophysical research communications 1997;237(1):79-83.
1997: Tetsuji Naka; Michiko Narazaki; M Hirata; Takuya Matsumoto; S Minamoto; A Aono; N Nishimoto; T Kajita; Tetsuya Taga; Kazuyuki Yoshizaki; S Akira; Tadamitsu Kishimoto
Structure and function of a new STAT-induced STAT inhibitor.
Nature 1997;387(6636):924-9.
1997: K Nakashima; Michiko Narazaki; Tetsuya Taga
Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130.
FEBS letters 1997;403(1):79-82.
1997: I S Lee; Y Liu; Michiko Narazaki; Masahiko Hibi; Tadamitsu Kishimoto; Tetsuya Taga
Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6.
FEBS letters 1997;401(2-3):133-7.
1997: K Nakashima; Michiko Narazaki; Tetsuya Taga
Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130.
FEBS letters 1997;401(1):49-52.
1995: Tadamitsu Kishimoto; S Akira; Michiko Narazaki; Tetsuya Taga
Interleukin-6 family of cytokines and gp130.
Blood 1995;86(4):1243-54.
1994: Michiko Narazaki; bruce witthuhn; Kanji Yoshida; O Silvennoinen; K Yasukawa; James N Ihle; Tadamitsu Kishimoto; Tetsuya Taga
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2285-9.
1993: Michiko Narazaki; K Yasukawa; T Saito; Yoshiyuki Ohsugi; H Fukui; Y Koishihara; G D Yancopoulos; Tetsuya Taga; Tadamitsu Kishimoto
Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130.
Blood 1993;82(4):1120-6.
1993: H Suzuki; K Yasukawa; T Saito; Michiko Narazaki; A Hasegawa; Tetsuya Taga; Tadamitsu Kishimoto
Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal.
European journal of immunology 1993;23(5):1078-82.
1992: Tetsuya Taga; Michiko Narazaki; K Yasukawa; T Saito; D Miki; M Hamaguchi; S Davis; M Shoyab; G D Yancopoulos; Tadamitsu Kishimoto
Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10998-1001.
1992: K Yasukawa; K Futatsugi; T Saito; H Yawata; Michiko Narazaki; H Suzuki; Tetsuya Taga; Tadamitsu Kishimoto
Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130.
Immunology letters 1992;31(2):123-30.
1992: Tetsuya Taga; Masahiko Hibi; M Murakami; M Saito; H Yawata; Michiko Narazaki; Y Hirata; T Sugita; K Yasukawa; Toshio Hirano
Interleukin-6 receptor and signals.
Chemical immunology 1992;51():181-204.
1992: Tadamitsu Kishimoto; Masahiko Hibi; M Murakami; Michiko Narazaki; M Saito; Tetsuya Taga
The molecular biology of interleukin 6 and its receptor.
Ciba Foundation symposium 1992;167():5-16; discussion 16-23.
1991: M Murakami; Michiko Narazaki; Masahiko Hibi; H Yawata; K Yasukawa; M Hamaguchi; Tetsuya Taga; Tadamitsu Kishimoto
Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11349-53.