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Shizuo Narimatsu
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38
Masubuchi, Yasuhiro
30
Yamamoto, Shigeo
26
Hanioka, Nobumitsu
16
Naito, Shinsaku
14
Horie, Toshiharu
10
Masuda, Kazufumi
10
Shinoda, Sumio
9
Hichiya, Hiroyuki
8
Tsuzuki, Daisuke
7
Yamano, Shigeru
7
Saito, Keita
7
Funae, Yoshihiko
7
Katsu, Takashi
6
Kiryu, Kimio
6
Koeda, Akiko
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All Publications
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2009: Nonaka Y; Saito K; Hanioka N; Narimatsu S; Kataoka H
Determination of aflatoxins in food samples by automated on-line in-tube solid-phase microextraction coupled with liquid chromatography-mass spectrometry.
Journal of chromatography. A 2009;1216(20):4416-22.
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2009: Narimatsu Shizuo; Kazamori Daichi; Masuda Kazufumi; Katsu Takashi; Funae Yoshihiko; Naito Shinsaku; Nakura Hironori; Yamano Shigeru; Hanioka Nobumitsu
The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol.
Biochemical pharmacology 2009;77(5):920-31.
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2008: Hanioka Nobumitsu; Naito Takanori; Narimatsu Shizuo
Human UDP-glucuronosyltransferase isoforms involved in bisphenol A glucuronidation.
Chemosphere 2008;74(1):33-6.
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2008: Katsu Takashi; Tsunamoto Yumi; Hanioka Nobumitsu; Komagoe Keiko; Masuda Kazufumi; Narimatsu Shizuo
A caffeine-sensitive membrane electrode: previous misleading report and present approach.
Analytica chimica acta 2008;620(1-2):50-4.
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2008: Hanioka Nobumitsu; Takeda Yuri; Tanaka-Kagawa Toshiko; Hayashi Keiko; Jinno Hideto; Narimatsu Shizuo
Interaction of bisphenol A with human UDP-glucuronosyltransferase 1A6 enzyme.
Environmental toxicology 2008;23(3):407-12.
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2008: Hanioka Nobumitsu; Tsuneto Yumi; Saito Yoshiro; Maekawa Keiko; Sawada Jun-Ichi; Narimatsu Shizuo
Influence of CYP2C19*18 and CYP2C19*19 alleles on omeprazole 5-hydroxylation: in vitro functional analysis of recombinant enzymes expressed in Saccharomyces cerevisiae.
Basic & clinical pharmacology & toxicology 2008;102(4):388-93.
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2008: Niwa Toshiro; Okada Kazushi; Hiroi Toyoko; Imaoka Susumu; Narimatsu Shizuo; Funae Yoshihiko
Effect of psychotropic drugs on the 21-hydroxylation of neurosteroids, progesterone and allopregnanolone, catalyzed by rat CYP2D4 and human CYP2D6 in the brain.
Biological & pharmaceutical bulletin 2008;31(3):348-51.
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2008: Narimatsu Shizuo; Kiryu Kimio; Yonemoto Rei; Yoshino Manabu; Kobatake Mitsuko; Kazamori Daichi; Hagino Saori; Masuda Kazufumi; Katsu Takashi; Asanuma Masato; Kumamoto Takuya; Ishikawa Tsutomu; Funae Yoshihiko; Yamano Shigeru; Hanioka Nobumitsu; Naito Shinsaku
The roles of amino acid residues at positions 216 and 219 in the structural stability and metabolic functions of rat cytochrome P450 2D1 and 2D2.
Chemico-biological interactions 2008;172(1):11-21.
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2008: Narimatsu Shizuo; Yonemoto Rei; Masuda Kazufumi; Katsu Takashi; Asanuma Masato; Kamata Tooru; Katagi Munehiro; Tsuchihashi Hitoshi; Kumamoto Takuya; Ishikawa Tsutomu; Naito Shinsaku; Yamano Shigeru; Hanioka Nobumitsu
Oxidation of 5-methoxy-N,N-diisopropyltryptamine in rat liver microsomes and recombinant cytochrome P450 enzymes.
Biochemical pharmacology 2008;75(3):752-60.
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2008: Hanioka Nobumitsu; Hayashi Keiko; Shimizudani Takeshi; Nagaoka Kenjiro; Koeda Akiko; Naito Shinsaku; Narimatsu Shizuo
Stereoselective glucuronidation of propranolol in human and cynomolgus monkey liver microsomes: role of human hepatic UDP-glucuronosyltransferase isoforms, UGT1A9, UGT2B4 and UGT2B7.
Pharmacology 2008;82(4):293-303.
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2008: Nishimura Masuhiro; Koeda Akiko; Shimizu Takefumi; Nakayama Mitsuo; Satoh Tetsuo; Narimatsu Shizuo; Naito Shinsaku
Comparison of inducibility of sulfotransferase and UDP-glucuronosyltransferase mRNAs by prototypical microsomal enzyme inducers in primary cultures of human and cynomolgus monkey hepatocytes.
Drug metabolism and pharmacokinetics 2008;23(1):45-53.
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2007: Hanioka Nobumitsu; Yamamoto Maki; Iwabu Hiroyuki; Jinno Hideto; Tanaka-Kagawa Toshiko; Naito Shinsaku; Shimizu Takefumi; Masuda Kazufumi; Katsu Takashi; Narimatsu Shizuo
Functional characterization of human and cynomolgus monkey cytochrome P450 2E1 enzymes.
Life sciences 2007;81(19-20):1436-45.
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2007: Saito Keita; Dan Hikari; Masuda Kazufumi; Katsu Takashi; Hanioka Nobumitsu; Yamamoto Shigeo; Miyano Kazuko; Yamano Shigeru; Narimatsu Shizuo
Stereoselective hexobarbital 3'-hydroxylation by CYP2C19 expressed in yeast cells and the roles of amino acid residues at positions 300 and 476.
Chirality 2007;19(7):550-8.
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2007: Nishimura Masuhiro; Koeda Akiko; Suganuma Yasuyuki; Suzuki Emako; Shimizu Takefumi; Nakayama Mitsuo; Satoh Tetsuo; Narimatsu Shizuo; Naito Shinsaku
Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes.
Drug metabolism and pharmacokinetics 2007;22(3):178-86.
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2007: Hanioka N; Tsuneto Y; Saito Y; Sumada T; Maekawa K; Saito K; Sawada J; Narimatsu S
Functional characterization of two novel CYP2C19 variants (CYP2C19*18 and CYP2C19*19) found in a Japanese population.
Xenobiotica; the fate of foreign compounds in biological systems 2007;37(4):342-55.
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2007: Katsu Takashi; Tsunamoto Yumi; Hanioka Nobumitsu; Komagoe Keiko; Masuda Kazufumi; Narimatsu Shizuo
S,S,S-Tris(2-ethylhexyl) phosphorotrithioate as an effective solvent mediator for a mexiletine-sensitive membrane electrode.
Analytical and bioanalytical chemistry 2007;387(6):2057-64.
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2006: Hanioka Nobumitsu; Takeda Yuri; Jinno Hideto; Tanaka-Kagawa Toshiko; Naito Shinsaku; Koeda Akiko; Shimizu Takefumi; Nomura Mamoru; Narimatsu Shizuo
Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A6 enzymes.
Chemico-biological interactions 2006;164(1-2):136-45.
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2006: Narimatsu Shizuo; Torigoe Fumihiro; Tsuneto Yumi; Saito Keita; Hanioka Nobumitsu; Masuda Kazufumi; Katsu Takashi; Yamamoto Shigeo; Yamano Shigeru; Baba Takahiko; Miyata Atsuro
Cloning of a cDNA encoding a novel marmoset CYP2C enzyme, expression in yeast cells and characterization of its enzymatic functions.
Biochemical pharmacology 2006;72(12):1738-48.
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2006: Suzuki Koichi; Tanabe Tomotaka; Moon Yong-Hwa; Funahashi Tatsuya; Nakao Hiroshi; Narimatsu Shizuo; Yamamoto Shigeo
Identification and transcriptional organization of aerobactin transport and biosynthesis cluster genes of Vibrio hollisae.
Research in microbiology 2006;157(8):730-40.
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2006: Nishimura Masuhiro; Koeda Akiko; Suzuki Emako; Kawano Yuichi; Nakayama Mitsuo; Satoh Tetsuo; Narimatsu Shizuo; Naito Shinsaku
Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsomal enzyme inducers in primary cultures of human and rat hepatocytes.
Drug metabolism and pharmacokinetics 2006;21(4):297-307.
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2006: Nishimura Masuhiro; Koeda Akiko; Suzuki Emako; Shimizu Takefumi; Kawano Yuichi; Nakayama Mitsuo; Satoh Tetsuo; Narimatsu Shizuo; Naito Shinsaku
Effects of prototypical drug-metabolizing enzyme inducers on mRNA expression of housekeeping genes in primary cultures of human and rat hepatocytes.
Biochemical and biophysical research communications 2006;346(3):1033-9.
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2006: Hanioka Nobumitsu; Obika Nobuhiko; Nishimura Masuhiro; Jinno Hideto; Tanaka-Kagawa Toshiko; Saito Keita; Kiryu Kimio; Naito Shinsaku; Narimatsu Shizuo
Inducibility of UDP-glucuronosyltransferase 1As by beta-naphthoflavone in HepG2 cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(8):1251-60.
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2006: Hanioka Nobumitsu; Okumura Yoshihito; Saito Yoshiro; Hichiya Hiroyuki; Soyama Akiko; Saito Keita; Ueno Kazuyuki; Sawada Jun-ichi; Narimatsu Shizuo
Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: in vitro functional analysis of recombinant proteins expressed in Saccharomyces cerevisiae.
Biochemical pharmacology 2006;71(9):1386-95.
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2006: Narimatsu Shizuo; Yonemoto Rei; Saito Keita; Takaya Kazuo; Kumamoto Takuya; Ishikawa Tsutomu; Asanuma Masato; Funada Masahiko; Kiryu Kimio; Naito Shinsaku; Yoshida Yuzo; Yamamoto Shigeo; Hanioka Nobumitsu
Oxidative metabolism of 5-methoxy-N,N-diisopropyltryptamine (Foxy) by human liver microsomes and recombinant cytochrome P450 enzymes.
Biochemical pharmacology 2006;71(9):1377-85.
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2006: Masuda Kazufumi; Tamagake Keietsu; Katsu Takashi; Torigoe Fumihiro; Saito Keita; Hanioka Nobumitsu; Yamano Shigeru; Yamamoto Shigeo; Narimatsu Shizuo
Roles of phenylalanine at position 120 and glutamic acid at position 222 in the oxidation of chiral substrates by cytochrome P450 2D6.
Chirality 2006;18(3):167-76.
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2006: Narimatsu Shizuo; Takatsu Noriko; Yamano Shigeru; Inoue Yusuke; Hanioka Nobumitsu; Kiryu Kimio; Naito Shinsaku; Gonzalez Frank J; Yamamoto Shigeo
The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase.
Chemico-biological interactions 2006;159(1):47-57.
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2005: Saito Yoshiro; Hanioka Nobumitsu; Maekawa Keiko; Isobe Takashi; Tsuneto Yumi; Nakamura Ryosuke; Soyama Akiko; Ozawa Shogo; Tanaka-Kagawa Toshiko; Jinno Hideto; Narimatsu Shizuo; Sawada Jun-Ichi
Functional analysis of three CYP1A2 variants found in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(12):1905-10.
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2005: Tanabe Tomotaka; Takata Noriko; Naka Ayaka; Moon Yong-Hwa; Nakao Hiroshi; Inoue Yuji; Narimatsu Shizuo; Yamamoto Shigeo
Identification of an AraC-like regulator gene required for induction of the 78-kDa ferrioxamine B receptor in Vibrio vulnificus.
FEMS microbiology letters 2005;249(2):309-14.
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2005: Isobe Takashi; Hichiya Hiroyuki; Hanioka Nobumitsu; Yamamoto Shigeo; Shinoda Sumio; Funae Yoshihiko; Satoh Tetsuo; Yamano Shigeru; Narimatsu Shizuo
Different effects of desipramine on bufuralol 1''-hydroxylation by rat and human CYP2D enzymes.
Biological & pharmaceutical bulletin 2005;28(4):634-40.
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2005: Miyano Junko; Yamamoto Shigeo; Hanioka Nobumitsu; Narimatsu Shizuo; Ishikawa Tsutomu; Ogura Kenichiro; Watabe Tadashi; Nishimura Masuhiro; Ueda Nobuhiko; Naito Shinsaku
Involvement of SULT1A3 in elevated sulfation of 4-hydroxypropranolol in Hep G2 cells pretreated with beta-naphthoflavone.
Biochemical pharmacology 2005;69(6):941-50.
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2005: Narimatsu Shizuo; Oda Maiko; Hichiya Hiroyuki; Isobe Takashi; Asaoka Kazuo; Hanioka Nobumitsu; Yamano Shigeru; Shinoda Sumio; Yamamoto Shigeo
Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset cytochrome P450 1A2.
Chemico-biological interactions 2005;152(1):1-12.
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2005: Masuda Kazufumi; Tamagake Keietsu; Okuda Yukie; Torigoe Fumihiro; Tsuzuki Daisuke; Isobe Takashi; Hichiya Hiroyuki; Hanioka Nobumitsu; Yamamoto Shigeo; Narimatsu Shizuo
Change in enantioselectivity in bufuralol 1''-hydroxylation by the substitution of phenylalanine-120 by alanine in cytochrome P450 2D6.
Chirality 2005;17(1):37-43.
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2005: Tanabe Tomotaka; Naka Ayaka; Aso Hiroaki; Nakao Hiroshi; Narimatsu Shizuo; Inoue Yuji; Ono Tomomichi; Yamamoto Shigeo
A novel aerobactin utilization cluster in Vibrio vulnificus with a gene involved in the transcription regulation of the iutA homologue.
Microbiology and immunology 2005;49(9):823-34.
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2004: Narimatsu Shizuo; Imoto Kazuo; Isobe Takashi; Kiryu Kimio; Naito Shinsaku; Hichiya Hiroyuki; Funae Yoshihiko; Hanioka Nobumitsu; Yamamoto Shigeo
The roles of amino acid residues at positions 43 and 45 in microsomal contents and enzymatic functions of rat CYP2D1 and CYP2D2.
Biochemical and biophysical research communications 2004;324(2):627-33.
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2004: Niwa Toshiro; Hiroi Toyoko; Tsuzuki Daisuke; Yamamoto Shigeo; Narimatsu Shizuo; Fukuda Tsuyoshi; Azuma Junichi; Funae Yoshihiko
Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6.
Brain research. Molecular brain research 2004;129(1-2):117-23.
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2004: Mihara Kazutoshi; Tanabe Tomotaka; Yamakawa Yoshiko; Funahashi Tatsuya; Nakao Hiroshi; Narimatsu Shizuo; Yamamoto Shigeo
Identification and transcriptional organization of a gene cluster involved in biosynthesis and transport of acinetobactin, a siderophore produced by Acinetobacter baumannii ATCC 19606T.
Microbiology (Reading, England) 2004;150(Pt 8):2587-97.
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2004: Hichiya Hiroyuki; Kuramoto Shino; Yamamoto Shigeo; Shinoda Sumio; Hanioka Nobumitsu; Narimatsu Shizuo; Asaoka Kazuo; Miyata Atsuro; Iwata Shinichi; Nomoto Masahiro; Satoh Tetsuo; Kiryu Kimio; Ueda Nobuhiko; Naito Shinsaku; Tucker Geoffrey T; Ellis S Wynne
Cloning and functional expression of a novel marmoset cytochrome P450 2D enzyme, CYP2D30: comparison with the known marmoset CYP2D19.
Biochemical pharmacology 2004;68(1):165-75.
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2003: Funahashi Tatsuya; Tanabe Tomotaka; Aso Hiroaki; Nakao Hiroshi; Fujii Yoshio; Okamoto Keinosuke; Narimatsu Shizuo; Yamamoto Shigeo
An iron-regulated gene required for utilization of aerobactin as an exogenous siderophore in Vibrio parahaemolyticus.
Microbiology (Reading, England) 2003;149(Pt 5):1217-25.
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2003: Narimatsu Shizuo; Takemi Chie; Kuramoto Shino; Tsuzuki Daisuke; Hichiya Hiroyuki; Tamagake Keietsu; Yamamoto Shigeo
Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s.
Chirality 2003;15(4):333-9.
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2003: Mitani Kurie; Narimatsu Shizuo; Kataoka Hiroyuki
Determination of daidzein and genistein in soybean foods by automated on-line in-tube solid-phase microextraction coupled to high-performance liquid chromatography.
Journal of chromatography. A 2003;986(2):169-77.
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2003: Tsuzuki Daisuke; Hichiya Hiroyuki; Okuda Yukie; Yamamoto Shigeo; Tamagake Keietsu; Shinoda Sumio; Narimatsu Shizuo
Alteration in catalytic properties of human CYP2D6 caused by substitution of glycine-42 with arginine, lysine and glutamic acid.
Drug metabolism and pharmacokinetics 2003;18(1):79-85.
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2002: Narimatsu Shizuo; Takemi Chie; Tsuzuki Daisuke; Kataoka Hiroyuki; Yamamoto Shigeo; Shimada Noriaki; Suzuki Satoshi; Satoh Tetsuo; Meyer Urs A; Gonzalez Frank J
Stereoselective metabolism of bufuralol racemate and enantiomers in human liver microsomes.
The Journal of pharmacology and experimental therapeutics 2002;303(1):172-8.
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2002: Hichiya Hiroyuki; Takemi Chie; Tsuzuki Daisuke; Yamamoto Shigeo; Asaoka Kazuo; Suzuki Satoshi; Satoh Tetsuo; Shinoda Sumio; Kataoka Hiroyuki; Narimatsu Shizuo
Complementary DNA cloning and characterization of cytochrome P450 2D29 from Japanese monkey liver.
Biochemical pharmacology 2002;64(7):1101-10.
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2002: Yamamoto K; Masubuchi Y; Narimatsu S; Kobayashi S; Horie T
Toxicity of ethacrynic acid in isolated rat hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 2002;16(2):151-8.
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2002: Funahashi Tatsuya; Moriya Kaoru; Uemura Sachi; Miyoshi Shin-ichi; Shinoda Sumio; Narimatsu Shizuo; Yamamoto Shigeo
Identification and characterization of pvuA, a gene encoding the ferric vibrioferrin receptor protein in Vibrio parahaemolyticus.
Journal of bacteriology 2002;184(4):936-46.
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2001: Tsuzuki D; Takemi C; Yamamoto S; Tamagake K; Imaoka S; Funae Y; Kataoka H; Shinoda S; Narimatsu S
Functional evaluation of cytochrome P450 2D6 with Gly42Arg substitution expressed in Saccharomyces cerevisiae.
Pharmacogenetics 2001;11(8):709-18.
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2001: Narimatsu S; Arai T; Masubuchi Y; Horie T; Hosokawa M; Ueno K; Kataoka H; Yamamoto S; Ishikawa T; Cho A K
Inactivation of rat cytochrome P450 2D enzyme by a further metabolite of 4-hydroxypropranolol, the major and active metabolite of propranolol.
Biological & pharmaceutical bulletin 2001;24(9):988-94.
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2001: Yamamoto K; Masubuchi Y; Narimatsu S; Kobayashi S; Horie T
Rat liver microsomal lipid peroxidation produced during the oxidative metabolism of ethacrynic acid.
Pharmacology & toxicology 2001;88(4):176-80.
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2001: Kimoto R; Funahashi T; Yamamoto N; Miyoshi S; Narimatsu S; Yamamoto S
Identification and characterization of the sodA genes encoding manganese superoxide dismutases in Vibrio parahaemolyticus, Vibrio mimicus, and Vibrio vulnificus.
Microbiology and immunology 2001;45(2):135-42.
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2001: Narimatsu S; Kobayashi N; Asaoka K; Masubuchi Y; Horie T; Hosokawa M; Ishikawa T; Ohmori S; Kitada M; Miyano J; Kataoka H; Yamamoto S
High-performance liquid chromatographic analysis of the sulfation of 4-hydroxypropranolol enantiomers by monkey liver cytosol.
Chirality 2001;13(3):140-7.
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2000: Narimatsu S; Kobayashi N; Masubuchi Y; Horie T; Kakegawa T; Kobayashi H; Hardwick J P; Gonzalez F J; Shimada N; Ohmori S; Kitada M; Asaoka K; Kataoka H; Yamamoto S; Satoh T
Species difference in enantioselectivity for the oxidation of propranolol by cytochrome P450 2D enzymes.
Chemico-biological interactions 2000;127(1):73-90.
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2000: Yamamoto S; Mutoh N; Tsuzuki D; Ikai H; Nakao H; Shinoda S; Narimatsu S; Miyoshi S I
Cloning and characterization of the ddc homolog encoding L-2,4-diaminobutyrate decarboxylase in Enterobacter aerogenes.
Biological & pharmaceutical bulletin 2000;23(5):649-53.
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2000: Funahashi T; Fujiwara C; Okada M; Miyoshi S; Shinoda S; Narimatsu S; Yamamoto S
Characterization of Vibrio parahaemolyticus manganese-resistant mutants in reference to the function of the ferric uptake regulatory protein.
Microbiology and immunology 2000;44(12):963-70.
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1999: Narimatsu S; Yamamoto S; Kato R; Masubuchi Y; Horie T
Contribution of flavin-containing monooxygenase and cytochrome P450 to imipramine N-oxidation in rat hepatic microsomes.
Biological & pharmaceutical bulletin 1999;22(6):567-71.
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1999: Narimatsu S; Yamamoto S; Koitabashi T; Kato R; Masubuchi Y; Suzuki T; Horie T
Biphasic kinetics of imipramine N-oxidation in rat brain microsomes.
Biological & pharmaceutical bulletin 1999;22(3):253-6.
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1999: Yamamoto S; Okujo N; Miyoshi S; Shinoda S; Narimatsu S
Siderophore production of Vibrio parahaemolyticus strains from different sources.
Microbiology and immunology 1999;43(9):909-12.
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1999: Narimatsu S; Kato R; Horie T; Ono S; Tsutsui M; Yabusaki Y; Ohmori S; Kitada M; Ichioka T; Shimada N; Kato R; Ishikawa T
Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6.
Chirality 1999;11(1):1-9.
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1998: Doi H; Masubuchi Y; Narimatsu S; Nishigaki R; Horie T
Salicylic acid-induced lipid peroxidation in rat liver microsomes.
Research communications in molecular pathology and pharmacology 1998;100(3):265-71.
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1998: Nakamaru M; Masubuchi Y; Narimatsu S; Awazu S; Horie T
Evaluation of damaged small intestine of mouse following methotrexate administration.
Cancer chemotherapy and pharmacology 1998;41(2):98-102.
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1997: Masubuchi Y; Iwasa T; Hosokawa S; Suzuki T; Horie T; Imaoka S; Funae Y; Narimatsu S
Selective deficiency of debrisoquine 4-hydroxylase activity in mouse liver microsomes.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1435-41.
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1997: Narimatsu S; Arai T; Watanabe T; Masubuchi Y; Horie T; Suzuki T; Ishikawa T; Tsutsui M; Kumagai Y; Cho A K
Covalent binding of a reactive metabolite derived from propranolol and its active metabolite 4-hydroxypropranolol to hepatic microsomal proteins of the rat.
Chemical research in toxicology 1997;10(3):289-95.
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1996: Narimatsu S; Mizukami T; Huang Y; Masubuchi Y; Suzuki T
In-vitro metabolic interaction of bunitrolol enantiomers in rabbit liver microsomes.
The Journal of pharmacy and pharmacology 1996;48(11):1185-9.
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1996: Kariya S; Isozaki S; Uchino K; Suzuki T; Narimatsu S
Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes.
Biological & pharmaceutical bulletin 1996;19(11):1511-4.
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1996: Narimatsu S; Gotoh M; Masubuchi Y; Horie T; Ohmori S; Kitada M; Kageyama T; Asaoka K; Yamamoto I; Suzuki T
Stereoselectivity in bunitrolol 4-hydroxylation in liver microsomes from marmosets and Japanese monkeys.
Biological & pharmaceutical bulletin 1996;19(11):1429-33.
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1996: Masubuchi Y; Igarashi S; Suzuki T; Horie T; Narimatsu S
Imipramine-induced inactivation of a cytochrome P450 2D enzyme in rat liver microsomes: in relation to covalent binding of its reactive intermediate.
The Journal of pharmacology and experimental therapeutics 1996;279(2):724-31.
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1996: Masubuchi Y; Iwasa T; Fujita S; Suzuki T; Horie T; Narimatsu S
Regioselectivity and substrate concentration-dependency of involvement of the CYP2D subfamily in oxidative metabolism of amitriptyline and nortriptyline in rat liver microsomes.
The Journal of pharmacy and pharmacology 1996;48(9):925-9.
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1996: Narimatsu S; Mochida M; Matsumoto T; Masubuchi Y; Horie T; Nagata K; Funae Y; Cho A K; Suzuki T
Cytochrome P450 enzymes involved in the enhancement of propranolol N-desisopropylation after repeated administration of propranolol in rats.
Chemico-biological interactions 1996;101(3):207-24.
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1996: Masubuchi Y; Yamamoto K; Suzuki T; Horie T; Narimatsu S
Characterization of the oxidation reactions catalyzed by CYP2D enzyme in rat renal microsomes.
Life sciences 1996;58(26):2431-7.
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1996: Narimatsu S; Tachibana M; Masubuchi Y; Suzuki T
Cytochrome P4502D and -2C enzymes catalyze the oxidative N-demethylation of the parkinsonism-inducing substance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in rat liver microsomes.
Chemical research in toxicology 1996;9(1):93-8.
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1995: Kariya S; Isozaki S; Masubuchi Y; Suzuki T; Narimatsu S
Possible pharmacokinetic and pharmacodynamic factors affecting parkinsonism inducement by cinnarizine and flunarizine.
Biochemical pharmacology 1995;50(10):1645-50.
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1995: Masubuchi Y; Takahashii C; Fujio N; Horie T; Suzuki T; Imaoka S; Funae Y; Narimatsu S
Inhibition and induction of cytochrome P450 isozymes after repetitive administration of imipramine in rats.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(9):999-1003.
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1995: Narimatsu S; Tachibana M; Masubuchi Y; Imaoka S; Funae Y; Suzuki T
Cytochrome P450 isozymes involved in aromatic hydroxylation and side-chain N-desisopropylation of alprenolol in rat liver microsomes.
Biological & pharmaceutical bulletin 1995;18(8):1060-5.
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1995: Narimatsu S; Watanabe T; Masubuchi Y; Horie T; Kumagai Y; Cho A K; Imaoka S; Funae Y; Ishikawa T; Suzuki T
Characterization of a chemically reactive propranolol metabolite that binds to microsomal proteins of rat liver.
Chemical research in toxicology 1995;8(5):721-8.
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1994: Masubuchi Y; Narimatsu S; Hosokawa S; Suzuki T
Role of the CYP2D subfamily in metabolism-dependent covalent binding of propranolol to liver microsomal protein in rats.
Biochemical pharmacology 1994;48(10):1891-8.
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1994: Masubuchi Y; Hosokawa S; Horie T; Suzuki T; Ohmori S; Kitada M; Narimatsu S
Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(6):909-15.
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1994: Narimatsu S; Huang Y; Mizukami T; Masubuchi Y; Suzuki T
Development of a high-performance liquid chromatographic method for the analysis of enatiomer/enantiomer interaction in oxidative metabolism of bunitrolol in rat liver microsomes.
Analytical biochemistry 1994;222(1):256-61.
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1994: Narimatsu S; Masubuchi Y; Hosokawa S; Ohmori S; Kitada M; Suzuki T
Involvement of a cytochrome P4502D subfamily in human liver microsomal bunitrolol 4-hydroxylation.
Biological & pharmaceutical bulletin 1994;17(6):803-7.
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1994: Kagimoto N; Masubuchi Y; Fujita S; Narimatsu S; Suzuki T
Kinetic analysis of propranolol-induced impairment of its own metabolism in rats.
The Journal of pharmacy and pharmacology 1994;46(6):528-30.
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1993: Masubuchi Y; Umeda S; Igarashi S; Fujita S; Narimatsu S; Suzuki T
Participation of the CYP2D subfamily in lidocaine 3-hydroxylation and formation of a reactive metabolite covalently bound to liver microsomal protein in rats.
Biochemical pharmacology 1993;46(10):1867-9.
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1993: Masubuchi Y; Yamamoto L A; Uesaka M; Fujita S; Narimatsu S; Suzuki T
Substrate stereoselectivity and enantiomer/enantiomer interaction in propranolol metabolism in rat liver microsomes.
Biochemical pharmacology 1993;46(10):1759-65.
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1993: Masubuchi Y; Kagimoto N; Narimatsu S; Fujita S; Suzuki T
Regioselective contribution of the cytochrome P-450 2D subfamily to propranolol metabolism in rat liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):1012-6.
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1993: Narimatsu S; Kariya S; Isozaki S; Ohmori S; Kitada M; Hosokawa S; Masubuchi Y; Suzuki T
Involvement of CYP2D6 in oxidative metabolism of cinnarizine and flunarizine in human liver microsomes.
Biochemical and biophysical research communications 1993;193(3):1262-8.
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1992: Ishida R; Suzuki K; Masubuchi Y; Narimatsu S; Fujita S; Suzuki T
Enzymatic basis for the non-linearity of hepatic elimination of propranolol in the isolated perfused rat liver.
Biochemical pharmacology 1992;44(12):2281-8.
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1992: Kariya S; Isozaki S; Narimatsu S; Suzuki T
Oxidative metabolism of flunarizine in rat liver microsomes.
Research communications in chemical pathology and pharmacology 1992;78(1):85-95.
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1992: Kariya S; Isozaki S; Narimatsu S; Suzuki T
Oxidative metabolism of cinnarizine in rat liver microsomes.
Biochemical pharmacology 1992;44(7):1471-4.
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1992: Masubuchi Y; Araki J; Narimatsu S; Suzuki T
Metabolic activation of lidocaine and covalent binding to rat liver microsomal protein.
Biochemical pharmacology 1992;43(12):2551-7.
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1992: Ishida R; Obara S; Masubuchi Y; Narimatsu S; Fujita S; Suzuki T
Induction of propranolol metabolism by the azo dye sudan III in rats.
Biochemical pharmacology 1992;43(11):2489-92.
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1992: Suzuki T; Narimatsu S; Fujita S; Masubuchi Y; Umeda S; Imaoka S; Funae Y
Purification and characterization of a cytochrome P-450 isozyme catalyzing bunitrolol 4-hydroxylation in liver microsomes of male rats.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(3):367-73.
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1992: Masubuchi Y; Narimatsu S; Suzuki T
Activation of propranolol and irreversible binding to rat liver microsomes: strain differences and effects of inhibitors.
Biochemical pharmacology 1992;43(3):635-7.
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1992: Suzuki T; Fujita S; Narimatsu S; Masubuchi Y; Tachibana M; Ohta S; Hirobe M
Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4-tetrahydroisoquinoline in rat liver microsomes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):771-6.
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1991: Suzuki T; Narimatsu S; Fujita S; Masubuchi Y; Umeda S
Impairment of bunitrolol 4-hydroxylase activity in liver microsomes of dark agouti rats.
Biochemical pharmacology 1991;42(11):2241-4.
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