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Shuh Narumiya
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68
Ushikubi, Fumitaka
49
Sugimoto, Yukihiko
45
Ichikawa, Atsushi
33
Ishizaki, Toshimasa
23
Negishi, Manabu
21
Nakao, Kazuwa
21
Watanabe, Naoki
18
Tanaka, Issei
15
Matsuoka, Toshiyuki
14
Kakizuka, Akira
14
Kobayashi, Takuya
14
Bito, Haruhiko
14
Furuyashiki, Tomoyuki
12
Segi, Eri
10
Usui, Takeshi
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All Publications
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2009: Narumiya Shuh
Prostanoids and inflammation: a new concept arising from receptor knockout mice.
Journal of molecular medicine (Berlin, Germany) 2009;87(10):1015-22.
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2009: Honda Tetsuya; Matsuoka Toshiyuki; Ueta Mayumi; Kabashima Kenji; Miyachi Yoshiki; Narumiya Shuh
Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity.
The Journal of allergy and clinical immunology 2009;124(4):809-18.e2.
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2009: Popp Laura; Häussler Annett; Olliges Anke; Nüsing Rolf; Narumiya Shuh; Geisslinger Gerd; Tegeder Irmgard
Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.
European journal of pain (London, England) 2009;13(7):691-703.
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2009: Hoshino Tatsuya; Namba Takushi; Takehara Masaya; Nakaya Tadashi; Sugimoto Yukihiko; Araki Wataru; Narumiya Shuh; Suzuki Toshiharu; Mizushima Tohru
Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.
The Journal of biological chemistry 2009;284(27):18493-502.
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2009: Yodoi Rieko; Tamba Shigero; Morimoto Kazushi; Segi-Nishida Eri; Nishihara Mika; Ichikawa Atsushi; Narumiya Shuh; Sugimoto Yukihiko
RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly.
Endocrinology 2009;150(7):3345-52.
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2009: Yao Chengcan; Sakata Daiji; Esaki Yoshiyasu; Li Youxian; Matsuoka Toshiyuki; Kuroiwa Kenji; Sugimoto Yukihiko; Narumiya Shuh
Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion.
Nature medicine 2009;15(6):633-40.
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2009: Narumiya Shuh; Tanji Masahiro; Ishizaki Toshimasa
Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion.
Cancer metastasis reviews 2009;28(1-2):65-76.
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2009: Ogawa Yasuhumi; Suzuki Tatsunori; Oikawa Atsuhiko; Hosono Kanako; Kubo Hidehumi; Amano Hideki; Ito Yoshiya; Kitasato Hidero; Hayashi Izumi; Kato Tetsuki; Sugimoto Yukihiko; Narumiya Shuh; Watanabe Masahiko; Majima Masataka
Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth.
Biochemical and biophysical research communications 2009;382(4):720-5.
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2009: Monypenny James; Zicha Daniel; Higashida Chiharu; Oceguera-Yanez Fabian; Narumiya Shuh; Watanabe Naoki
Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis.
Molecular and cellular biology 2009;29(10):2730-47.
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2009: Saleem Sofiyan; Kim Yun Tai; Maruyama Takayuki; Narumiya Shuh; Doré Sylvain
Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia.
Journal of neuroimmunology 2009;208(1-2):87-93.
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2009: Furuyashiki Tomoyuki; Narumiya Shuh
Roles of prostaglandin E receptors in stress responses.
Current opinion in pharmacology 2009;9(1):31-8.
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2009: Miki Takashi; Okawa Katsuya; Sekimoto Toshihiro; Yoneda Yoshihiro; Watanabe Sadanori; Ishizaki Toshimasa; Narumiya Shuh
mDia2 shuttles between the nucleus and the cytoplasm through the importin-{alpha}/{beta}- and CRM1-mediated nuclear transport mechanism.
The Journal of biological chemistry 2009;284(9):5753-62.
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2009: Ueta Mayumi; Matsuoka Toshiyuki; Narumiya Shuh; Kinoshita Shigeru
Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis.
The Journal of allergy and clinical immunology 2009;123(2):466-71.
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2009: Saleem Sofiyan; Ahmad Abdullah Shafique; Maruyama Takayuki; Narumiya Shuh; Doré Sylvain
PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia.
Neurotoxicity research 2009;15(1):62-70.
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2009: Tsuji Takahiro; Miyoshi Takushi; Higashida Chiharu; Narumiya Shuh; Watanabe Naoki
An order of magnitude faster AIP1-associated actin disruption than nucleation by the Arp2/3 complex in lamellipodia.
PloS one 2009;4(3):e4921.
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2008: Nemenoff Raphael; Meyer Amy M; Hudish Tyler M; Mozer Anthony B; Snee Amy; Narumiya Shuh; Stearman Robert S; Winn Robert A; Weiser-Evans Mary; Geraci Mark W; Keith Robert L
Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of peroxisomal proliferator--activated receptor gamma.
Cancer prevention research (Philadelphia, Pa.) 2008;1(5):349-56.
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2008: Higashida Chiharu; Suetsugu Shiro; Tsuji Takahiro; Monypenny James; Narumiya Shuh; Watanabe Naoki
G-actin regulates rapid induction of actin nucleation by mDia1 to restore cellular actin polymers.
Journal of cell science 2008;121(Pt 20):3403-12.
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2008: Katagiri Hiroyuki; Ito Yoshiya; Ito Sohei; Murata Takahiko; Yukihiko Sugimoto; Narumiya Shuh; Watanabe Masahiko; Majima Masataka
TNF-alpha induces thromboxane receptor signaling-dependent microcirculatory dysfunction in mouse liver.
Shock (Augusta, Ga.) 2008;30(4):463-7.
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2008: Wei G; Kibler K K; Koehler R C; Maruyama T; Narumiya S; Doré S
Prostacyclin receptor deletion aggravates hippocampal neuronal loss after bilateral common carotid artery occlusion in mouse.
Neuroscience 2008;156(4):1111-7.
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2008: Tamba Shigero; Yodoi Rieko; Segi-Nishida Eri; Ichikawa Atsushi; Narumiya Shuh; Sugimoto Yukihiko
Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14539-44.
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2008: Matsuoka Toshiyuki; Narumiya Shuh
The roles of prostanoids in infection and sickness behaviors.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2008;14(4):270-8.
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2008: Watanabe Sadanori; Ando Yoshikazu; Yasuda Shingo; Hosoya Hiroshi; Watanabe Naoki; Ishizaki Toshimasa; Narumiya Shuh
mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells.
Molecular biology of the cell 2008;19(5):2328-38.
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2008: Yuhki Koh-Ichi; Ushikubi Fumitaka; Naraba Hiroaki; Ueno Akinori; Kato Hirotsugu; Kojima Fumiaki; Narumiya Shuh; Sugimoto Yukihiko; Matsushita Misao; Oh-Ishi Sachiko
Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy.
The Journal of pharmacology and experimental therapeutics 2008;325(2):601-9.
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2008: Wang Xiaojun; Momota Yoshiharu; Yanase Haruko; Narumiya Shuh; Maruyama Takayuki; Kawatani Masahito
Urothelium EP1 receptor facilitates the micturition reflex in mice.
Biomedical research (Tokyo, Japan) 2008;29(2):105-11.
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2008: Takeya Ryu; Taniguchi Kenichiro; Narumiya Shuh; Sumimoto Hideki
The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells.
The EMBO journal 2008;27(4):618-28.
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2008: Koyanagi Masaomi; Takahashi Jun; Arakawa Yoshiki; Doi Daisuke; Fukuda Hitoshi; Hayashi Hideki; Narumiya Shuh; Hashimoto Nobuo
Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors.
Journal of neuroscience research 2008;86(2):270-80.
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2008: Torres David; Paget Christophe; Fontaine Josette; Mallevaey Thierry; Matsuoka Toshiyuki; Maruyama Takayuki; Narumiya Shuh; Capron Monique; Gosset Philippe; Faveeuw Christelle; Trottein François
Prostaglandin D2 inhibits the production of IFN-gamma by invariant NK T cells: consequences in the control of B16 melanoma.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):783-92.
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2007: Kitaoka Shiho; Furuyashiki Tomoyuki; Nishi Akinori; Shuto Takahide; Koyasu Sho; Matsuoka Toshiyuki; Miyasaka Masayuki; Greengard Paul; Narumiya Shuh
Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(47):12900-7.
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2007: Nagamachi Miyako; Sakata Daiji; Kabashima Kenji; Furuyashiki Tomoyuki; Murata Takahiko; Segi-Nishida Eri; Soontrapa Kitipong; Matsuoka Toshiyuki; Miyachi Yoshiki; Narumiya Shuh
Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1.
The Journal of experimental medicine 2007;204(12):2865-74.
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2007: Hoshino Tatsuya; Nakaya Tadashi; Homan Takashi; Tanaka Ken-ichiro; Sugimoto Yukihiko; Araki Wataru; Narita Masami; Narumiya Shuh; Suzuki Toshiharu; Mizushima Tohru
Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo.
The Journal of biological chemistry 2007;282(45):32676-88.
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2007: Noguchi Michio; Hosoda Kiminori; Fujikura Junji; Fujimoto Muneya; Iwakura Hiroshi; Tomita Tsutomu; Ishii Takako; Arai Naoki; Hirata Masakazu; Ebihara Ken; Masuzaki Hiroaki; Itoh Hiroshi; Narumiya Shuh; Nakao Kazuwa
Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis.
The Journal of biological chemistry 2007;282(40):29574-83.
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2007: Ando Yoshikazu; Yasuda Shingo; Oceguera-Yanez Fabian; Narumiya Shuh
Inactivation of Rho GTPases with Clostridium difficile toxin B impairs centrosomal activation of Aurora-A in G2/M transition of HeLa cells.
Molecular biology of the cell 2007;18(10):3752-63.
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2007: Gopinath Suchitra Devi; Narumiya Shuh; Dhawan Jyotsna
The RhoA effector mDiaphanous regulates MyoD expression and cell cycle progression via SRF-dependent and SRF-independent pathways.
Journal of cell science 2007;120(Pt 17):3086-98.
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2007: Sakata Daiji; Taniguchi Hiroyuki; Yasuda Shingo; Adachi-Morishima Aki; Hamazaki Yoko; Nakayama Rika; Miki Takashi; Minato Nagahiro; Narumiya Shuh
Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1.
The Journal of experimental medicine 2007;204(9):2031-8.
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2007: Hristovska Ana-Marija; Rasmussen Lasse E; Hansen Pernille B L; Nielsen Susan S; Nüsing Rolf M; Narumiya Shuh; Vanhoutte Paul; Skøtt Ole; Jensen Boye L
Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthase.
Hypertension 2007;50(3):525-30.
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2007: Pelosi Michele; Marampon Francesco; Zani Bianca M; Prudente Sabrina; Perlas Emerald; Caputo Viviana; Cianetti Luciano; Berno Valeria; Narumiya Shuh; Kang Shin W; Musarò Antonio; Rosenthal Nadia
ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program.
Molecular and cellular biology 2007;27(17):6163-76.
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2007: Andoh Tsugunobu; Nishikawa Yumi; Yamaguchi-Miyamoto Tomomi; Nojima Hiroshi; Narumiya Shu; Kuraishi Yasushi
Thromboxane A2 induces itch-associated responses through TP receptors in the skin in mice.
The Journal of investigative dermatology 2007;127(8):2042-7.
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2007: Saleem Sofiyan; Zhuang Hean; de Brum-Fernandes Artur J; Maruyama Takayuki; Narumiya Shuh; Doré Sylvain
PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury.
The European journal of neuroscience 2007;26(1):73-8.
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2007: Ota Takashi; Aihara Makoto; Saeki Tadashiro; Narumiya Shuh; Araie Makoto
The IOP-lowering effects and mechanism of action of tafluprost in prostanoid receptor-deficient mice.
The British journal of ophthalmology 2007;91(5):673-6.
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2007: Taniguchi Hidetoshi; Mohri Ikuko; Okabe-Arahori Hitomi; Aritake Kosuke; Wada Kazuko; Kanekiyo Takahisa; Narumiya Shuh; Nakayama Masahiro; Ozono Keiichi; Urade Yoshihiro; Taniike Masako
Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(16):4303-12.
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2007: Sugimoto Yukihiko; Narumiya Shuh
Prostaglandin E receptors.
The Journal of biological chemistry 2007;282(16):11613-7.
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2007: Ahmad Muzamil; Ahmad Abdullah Shafique; Zhuang Hean; Maruyama Takayuki; Narumiya Shuh; Doré Sylvain
Stimulation of prostaglandin E2-EP3 receptors exacerbates stroke and excitotoxic injury.
Journal of neuroimmunology 2007;184(1-2):172-9.
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2007: Hammad Hamida; Kool Mirjam; Soullié Thomas; Narumiya Shuh; Trottein François; Hoogsteden Henk C; Lambrecht Bart N
Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells.
The Journal of experimental medicine 2007;204(2):357-67.
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2007: Kabashima Kenji; Nagamachi Miyako; Honda Tetsuya; Nishigori Chikako; Miyachi Yoshiki; Tokura Yoshiki; Narumiya Shuh
Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors.
Laboratory investigation; a journal of technical methods and pathology 2007;87(1):49-55.
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2007: Matsuoka Toshiyuki; Narumiya Shuh
Prostaglandin receptor signaling in disease.
TheScientificWorldJournal 2007;7():1329-47.
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2006: Miyoshi Takushi; Tsuji Takahiro; Higashida Chiharu; Hertzog Maud; Fujita Akiko; Narumiya Shuh; Scita Giorgio; Watanabe Naoki
Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing.
The Journal of cell biology 2006;175(6):947-55.
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2006: Zhuge Xin; Arai Hidenori; Xu Yang; Murayama Toshinori; Kobayashi Takuya; Narumiya Shuh; Kita Toru; Yokode Masayuki
Protection of atherogenesis in thromboxane A2 receptor-deficient mice is not associated with thromboxane A2 receptor in bone marrow-derived cells.
Biochemical and biophysical research communications 2006;351(4):865-71.
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2006: Hösl Katharina; Reinold Heiko; Harvey Robert J; Müller Ulrike; Narumiya Shuh; Zeilhofer Hanns Ulrich
Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor alpha3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain after peripheral nerve injury or formalin injection.
Pain 2006;126(1-3):46-53.
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2006: Qu Wei-Min; Huang Zhi-Li; Xu Xin-Hong; Aritake Kosuke; Eguchi Naomi; Nambu Fumio; Narumiya Shu; Urade Yoshihiro; Hayaishi Osamu
Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17949-54.
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2006: Yang Li; Huang Yuhui; Porta Rut; Yanagisawa Kiyoshi; Gonzalez Adriana; Segi Eric; Johnson David H; Narumiya Shuh; Carbone David P
Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism.
Cancer research 2006;66(19):9665-72.
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2006: Kamoshita Emi; Ikeda Yasuhiro; Fujita Mamoru; Amano Hideki; Oikawa Atsuhiko; Suzuki Tastunori; Ogawa Yasuhumi; Yamashina Shohei; Azuma Sadahiro; Narumiya Shuh; Unno Nobuya; Majima Masataka
Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound-induced angiogenesis.
The American journal of pathology 2006;169(4):1458-72.
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2006: Yamana Norikazu; Arakawa Yoshiki; Nishino Tomohiro; Kurokawa Kazuo; Tanji Masahiro; Itoh Reina E; Monypenny James; Ishizaki Toshimasa; Bito Haruhiko; Nozaki Kazuhiko; Hashimoto Nobuo; Matsuda Michiyuki; Narumiya Shuh
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src.
Molecular and cellular biology 2006;26(18):6844-58.
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2006: Ota Takashi; Aihara Makoto; Saeki Tadashiro; Narumiya Shuh; Araie Makoto
The effects of prostaglandin analogues on prostanoid EP1, EP2, and EP3 receptor-deficient mice.
Investigative ophthalmology & visual science 2006;47(8):3395-9.
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2006: Ohmae Shogo; Takemoto-Kimura Sayaka; Okamura Michiko; Adachi-Morishima Aki; Nonaka Mio; Fuse Toshimitsu; Kida Satoshi; Tanji Masahiro; Furuyashiki Tomoyuki; Arakawa Yoshiki; Narumiya Shuh; Okuno Hiroyuki; Bito Haruhiko
Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV.
The Journal of biological chemistry 2006;281(29):20427-39.
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2006: Yasuda Shingo; Taniguchi Hiroyuki; Oceguera-Yanez Fabian; Ando Yoshikazu; Watanabe Sadanori; Monypenny James; Narumiya Shuh
An essential role of Cdc42-like GTPases in mitosis of HeLa cells.
FEBS letters 2006;580(14):3375-80.
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2006: Mohri Ikuko; Taniike Masako; Taniguchi Hidetoshi; Kanekiyo Takahisa; Aritake Kosuke; Inui Takashi; Fukumoto Noriko; Eguchi Naomi; Kushi Atsuko; Sasai Hitoshi; Kanaoka Yoshihide; Ozono Keiichi; Narumiya Shuh; Suzuki Kinuko; Urade Yoshihiro
Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(16):4383-93.
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2006: Narumiya Shuh; Yasuda Shingo
Rho GTPases in animal cell mitosis.
Current opinion in cell biology 2006;18(2):199-205.
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2006: Honda Tetsuya; Segi-Nishida Eri; Miyachi Yoshiki; Narumiya Shuh
Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis.
The Journal of experimental medicine 2006;203(2):325-35.
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2006: Yasuda Shingo; Narumiya Shuh
Analysis of a mitotic role of Cdc42.
Methods in enzymology 2006;406():656-65.
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2006: Oceguera-Yanez Fabian; Narumiya Shuh
Measurement of activity of rho GTPases during mitosis.
Methods in enzymology 2006;406():332-45.
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2005: Shoji Yutaka; Takahashi Mami; Takasuka Nobuo; Niho Naoko; Kitamura Tomohiro; Sato Hidetaka; Maruyama Takayuki; Sugimoto Yukihiko; Narumiya Shuh; Sugimura Takashi; Wakabayashi Keiji
Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis.
Carcinogenesis 2005;26(12):2116-22.
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2005: Ota Takashi; Aihara Makoto; Narumiya Shuh; Araie Makoto
The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice.
Investigative ophthalmology & visual science 2005;46(11):4159-63.
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2005: Matsuoka Yoko; Furuyashiki Tomoyuki; Yamada Kiyofumi; Nagai Taku; Bito Haruhiko; Tanaka Yasuhiro; Kitaoka Shiho; Ushikubi Fumitaka; Nabeshima Toshitaka; Narumiya Shuh
Prostaglandin E receptor EP1 controls impulsive behavior under stress.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):16066-71.
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2005: Emoto Kazuo; Inadome Hironori; Kanaho Yasunori; Narumiya Shuh; Umeda Masato
Local change in phospholipid composition at the cleavage furrow is essential for completion of cytokinesis.
The Journal of biological chemistry 2005;280(45):37901-7.
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2005: Ito Hidenori; Iwamoto Ikuko; Morishita Rika; Nozawa Yoshinori; Narumiya Shuh; Asano Tomiko; Nagata Koh-Ichi
Possible role of Rho/Rhotekin signaling in mammalian septin organization.
Oncogene 2005;24(47):7064-72.
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2005: Takasaki Ichiro; Nojima Hiroshi; Shiraki Kimiyasu; Sugimoto Yukihiko; Ichikawa Atsushi; Ushikubi Fumitaka; Narumiya Shuh; Kuraishi Yasushi
Involvement of cyclooxygenase-2 and EP3 prostaglandin receptor in acute herpetic but not postherpetic pain in mice.
Neuropharmacology 2005;49(3):283-92.
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2005: Thumkeo Dean; Shimizu Yoshihiko; Sakamoto Satoko; Yamada Shuichi; Narumiya Shuh
ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(8):825-34.
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2005: Nüsing Rolf M; Treude Antje; Weissenberger Christian; Jensen Boye; Bek Martin; Wagner Charlotte; Narumiya Shuh; Seyberth Hannsjörg W
Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome.
Journal of the American Society of Nephrology : JASN 2005;16(8):2354-62.
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2005: Hara Akiyoshi; Yuhki Koh-ichi; Fujino Takayuki; Yamada Takehiro; Takayama Koji; Kuriyama Shuhko; Takahata Osamu; Karibe Hideji; Okada Yuji; Xiao Chun-Yang; Ma Hong; Narumiya Shuh; Ushikubi Fumitaka
Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor.
Circulation 2005;112(1):84-92.
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2005: Takayama Koji; Yuhki Koh-ichi; Ono Kyoichi; Fujino Takayuki; Hara Akiyoshi; Yamada Takehiro; Kuriyama Shuhko; Karibe Hideji; Okada Yuji; Takahata Osamu; Taniguchi Takanobu; Iijima Toshihiko; Iwasaki Hiroshi; Narumiya Shuh; Ushikubi Fumitaka
Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia.
Nature medicine 2005;11(5):562-6.
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2005: Kunikata Tomonori; Yamane Hana; Segi Eri; Matsuoka Toshiyuki; Sugimoto Yukihiko; Tanaka Satoshi; Tanaka Hiroyuki; Nagai Hiroichi; Ichikawa Atsushi; Narumiya Shuh
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3.
Nature immunology 2005;6(5):524-31.
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2005: Riol-Blanco Lorena; Sánchez-Sánchez Noelia; Torres Ana; Tejedor Alberto; Narumiya Shuh; Corbí Angel L; Sánchez-Mateos Paloma; Rodríguez-Fernández José Luis
The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4070-80.
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2005: Shimizu Yoshihiko; Thumkeo Dean; Keel Jeongsin; Ishizaki Toshimasa; Oshima Hiroko; Oshima Masanobu; Noda Yoichi; Matsumura Fumio; Taketo Makoto M; Narumiya Shuh
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles.
The Journal of cell biology 2005;168(6):941-53.
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2005: Reinold Heiko; Ahmadi Seifollah; Depner Ulrike B; Layh Beate; Heindl Cornelia; Hamza May; Pahl Andreas; Brune Kay; Narumiya Shuh; Müller Ulrike; Zeilhofer Hanns Ulrich
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype.
The Journal of clinical investigation 2005;115(3):673-9.
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2005: Kawamori Toshihiko; Kitamura Tomohiro; Watanabe Kouji; Uchiya Naoaki; Maruyama Takayuki; Narumiya Shuh; Sugimura Takashi; Wakabayashi Keiji
Prostaglandin E receptor subtype EP(1) deficiency inhibits colon cancer development.
Carcinogenesis 2005;26(2):353-7.
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2005: Oceguera-Yanez Fabian; Kimura Kazuhiro; Yasuda Shingo; Higashida Chiharu; Kitamura Toshio; Hiraoka Yasushi; Haraguchi Tokuko; Narumiya Shuh
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
The Journal of cell biology 2005;168(2):221-32.
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2005: Watanabe Hidetsuna; Katoh Tetsuo; Eiro Masaaki; Iwamoto Masaya; Ushikubi Fumitaka; Narumiya Shuh; Watanabe Tsuyoshi
Effects of salt loading on blood pressure in mice lacking the prostanoid receptor gene.
Circulation journal : official journal of the Japanese Circulation Society 2005;69(1):124-6.
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2005: Moriyama Tomoko; Higashi Tomohiro; Togashi Kazuya; Iida Tohko; Segi Eri; Sugimoto Yukihiko; Tominaga Tomoko; Narumiya Shuh; Tominaga Makoto
Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins.
Molecular pain 2005;1():3.
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2004: Yuhki Koh-ichi; Ueno Akinori; Naraba Hiroaki; Kojima Fumiaki; Ushikubi Fumitaka; Narumiya Shuh; Oh-ishi Sachiko
Prostaglandin receptors EP2, EP3, and IP mediate exudate formation in carrageenin-induced mouse pleurisy.
The Journal of pharmacology and experimental therapeutics 2004;311(3):1218-24.
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2004: Fujino Takayuki; Nakagawa Naoki; Yuhki Koh-Ichi; Hara Akiyoshi; Yamada Takehiro; Takayama Koji; Kuriyama Shuhko; Hosoki Yayoi; Takahata Osamu; Taniguchi Takanobu; Fukuzawa Jun; Hasebe Naoyuki; Kikuchi Kenjiro; Narumiya Shuh; Ushikubi Fumitaka
Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP.
The Journal of clinical investigation 2004;114(6):805-12.
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2004: Kobayashi Takuya; Tahara Yoshio; Matsumoto Mayumi; Iguchi Masako; Sano Hideto; Murayama Toshinori; Arai Hidenori; Oida Hiroji; Yurugi-Kobayashi Takami; Yamashita Jun K; Katagiri Hiroyuki; Majima Masataka; Yokode Masayuki; Kita Toru; Narumiya Shuh
Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice.
The Journal of clinical investigation 2004;114(6):784-94.
-
2004: Schweda Frank; Klar Jürgen; Narumiya Shuh; Nüsing Rolf M; Kurtz Armin
Stimulation of renin release by prostaglandin E2 is mediated by EP2 and EP4 receptors in mouse kidneys.
American journal of physiology. Renal physiology 2004;287(3):F427-33.
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2004: Shoji Y; Takahashi M; Kitamura T; Watanabe K; Kawamori T; Maruyama T; Sugimoto Y; Negishi M; Narumiya S; Sugimura T; Wakabayashi K
Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development.
Gut 2004;53(8):1151-8.
-
2004: Ueda Hiroshi; Morishita Rika; Narumiya Shuh; Kato Kanefusa; Asano Tomiko
Galphaq/11 signaling induces apoptosis through two pathways involving reduction of Akt phosphorylation and activation of RhoA in HeLa cells.
Experimental cell research 2004;298(1):207-17.
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2004: Narumiya Shuh; Oceguera-Yanez Fabian; Yasuda Shingo
A new look at Rho GTPases in cell cycle: role in kinetochore-microtubule attachment.
Cell cycle (Georgetown, Tex.) 2004;3(7):855-7.
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2004: Xiao Chun-Yang; Yuhki Koh-ichi; Hara Akiyoshi; Fujino Takayuki; Kuriyama Shuhko; Yamada Takehiro; Takayama Koji; Takahata Osamu; Karibe Hideji; Taniguchi Takanobu; Narumiya Shuh; Ushikubi Fumitaka
Prostaglandin E2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP4.
Circulation 2004;109(20):2462-8.
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2004: Yasuda Shingo; Oceguera-Yanez Fabian; Kato Takayuki; Okamoto Muneo; Yonemura Shigenobu; Terada Yasuhiko; Ishizaki Toshimasa; Narumiya Shuh
Cdc42 and mDia3 regulate microtubule attachment to kinetochores.
Nature 2004;428(6984):767-71.
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2004: Marinissen Maria Julia; Chiariello Mario; Tanos Tamara; Bernard Ora; Narumiya Shuh; Gutkind J Silvio
The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis.
Molecular cell 2004;14(1):29-41.
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2004: Higashida Chiharu; Miyoshi Takushi; Fujita Akiko; Oceguera-Yanez Fabian; Monypenny James; Andou Yoshikazu; Narumiya Shuh; Watanabe Naoki
Actin polymerization-driven molecular movement of mDia1 in living cells.
Science (New York, N.Y.) 2004;303(5666):2007-10.
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2004: Shimada Atsushi; Nyitrai Miklós; Vetter Ingrid R; Kühlmann Dorothee; Bugyi Beáta; Narumiya Shuh; Geeves Michael A; Wittinghofer Alfred
The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization.
Molecular cell 2004;13(4):511-22.
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2004: Katagiri Hiroyuki; Ito Yoshiya; Ishii Ken-ichiro; Hayashi Izumi; Suematsu Makoto; Yamashina Shohei; Murata Takahiko; Narumiya Shuh; Kakita Akira; Majima Masataka
Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice.
Hepatology (Baltimore, Md.) 2004;39(1):139-50.
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2004: Giagulli Cinzia; Scarpini Elio; Ottoboni Linda; Narumiya Shuh; Butcher Eugene C; Constantin Gabriela; Laudanna Carlo
RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing.
Immunity 2004;20(1):25-35.
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2003: Suganami Takayoshi; Mori Kiyoshi; Tanaka Issei; Mukoyama Masashi; Sugawara Akira; Makino Hisashi; Muro Seiji; Yahata Kensei; Ohuchida Shuichi; Maruyama Takayuki; Narumiya Shuh; Nakao Kazuwa
Role of prostaglandin E receptor EP1 subtype in the development of renal injury in genetically hypertensive rats.
Hypertension 2003;42(6):1183-90.
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2003: Narumiya Shuh
Prostanoids in immunity: roles revealed by mice deficient in their receptors.
Life sciences 2003;74(2-3):391-5.
-
2003: Hara Akiyoshi; Yuhki Koh-ichi; Fujino Takayuki; Narumiya Shuh; Ushikubi Fumitaka
[Pathophysiological roles of the prostanoids in the cardiovascular system: studies using mice deficient in prostanoid receptors]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(5):384-90.
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2003: Yamada Takehiro; Fujino Takayuki; Yuhki Koh-ichi; Hara Akiyoshi; Karibe Hideji; Takahata Osamu; Okada Yuji; Xiao Chun-Yang; Takayama Koji; Kuriyama Shuhko; Taniguchi Takanobu; Shiokoshi Takahiro; Ohsaki Yoshinobu; Kikuchi Kenjiro; Narumiya Shuh; Ushikubi Fumitaka
Thromboxane A2 regulates vascular tone via its inhibitory effect on the expression of inducible nitric oxide synthase.
Circulation 2003;108(19):2381-6.
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2003: Hervé Maxime; Angeli Véronique; Pinzar Elena; Wintjens René; Faveeuw Christelle; Narumiya Shuh; Capron André; Urade Yoshihiro; Capron Monique; Riveau Gilles; Trottein François
Pivotal roles of the parasite PGD2 synthase and of the host D prostanoid receptor 1 in schistosome immune evasion.
European journal of immunology 2003;33(10):2764-72.
-
2003: Narumiya Shuh
Signal transduction underlying cell morphogenesis: editorial overview.
Journal of biochemistry 2003;134(3):305-7.
-
2003: Arai K; Ohno T; Saeki T; Mizuguchi S; Kamata K; Hayashi I; Saigenji K; Murata T; Narumiya S; Majima M
Endogenous prostaglandin I2 regulates the neural emergency system through release of calcitonin gene related peptide.
Gut 2003;52(9):1242-9.
-
2003: Oka Takakazu; Oka Kae; Kobayashi Takuya; Sugimoto Yukihiko; Ichikawa Atsushi; Ushikubi Fumitaka; Narumiya Shuh; Saper Clifford B
Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors.
The Journal of physiology 2003;551(Pt 3):945-54.
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2003: Nagao Koichi; Tanaka Hiroyuki; Komai Masato; Masuda Taisei; Narumiya Shuh; Nagai Hiroichi
Role of prostaglandin I2 in airway remodeling induced by repeated allergen challenge in mice.
American journal of respiratory cell and molecular biology 2003;29(3 Pt 1):314-20.
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2003: Kabashima Kenji; Narumiya Shuh
The DP receptor, allergic inflammation and asthma.
Prostaglandins, leukotrienes, and essential fatty acids 2003;69(2-3):187-94.
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2003: Otomo Asako; Hadano Shinji; Okada Takeya; Mizumura Hikaru; Kunita Ryota; Nishijima Hitoshi; Showguchi-Miyata Junko; Yanagisawa Yoshiko; Kohiki Eri; Suga Etsuko; Yasuda Masanori; Osuga Hitoshi; Nishimoto Takeharu; Narumiya Shuh; Ikeda Joh-E
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics.
Human molecular genetics 2003;12(14):1671-87.
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2003: Thumkeo Dean; Keel Jeongsin; Ishizaki Toshimasa; Hirose Masaya; Nonomura Kimiko; Oshima Hiroko; Oshima Masanobu; Taketo Makoto M; Narumiya Shuh
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death.
Molecular and cellular biology 2003;23(14):5043-55.
-
2003: Minami Toshiaki; Matsumura Shinji; Mabuchi Tamaki; Kobayashi Takuya; Sugimoto Yukihiko; Ushikubi Fumitaka; Ichikawa Atsushi; Narumiya Shuh; Ito Seiji
Functional evidence for interaction between prostaglandin EP3 and kappa-opioid receptor pathways in tactile pain induced by human immunodeficiency virus type-1 (HIV-1) glycoprotein gp120.
Neuropharmacology 2003;45(1):96-105.
-
2003: Kabashima Kenji; Murata Takahiko; Tanaka Hiroyuki; Matsuoka Toshiyuki; Sakata Daiji; Yoshida Nobuaki; Katagiri Koko; Kinashi Tatsuo; Tanaka Toshiyuki; Miyasaka Masayuki; Nagai Hiroichi; Ushikubi Fumitaka; Narumiya Shuh
Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity.
Nature immunology 2003;4(7):694-701.
-
2003: Kabashima Kenji; Sakata Daiji; Nagamachi Miyako; Miyachi Yoshiki; Inaba Kayo; Narumiya Shuh
Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells.
Nature medicine 2003;9(6):744-9.
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2003: Saito Osamu; Guan Youfei; Qi Zhonghua; Davis Linda S; Kömhoff Martin; Sugimoto Yukihiko; Narumiya Shuh; Breyer Richard M; Breyer Matthew D
Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract.
American journal of physiology. Renal physiology 2003;284(6):F1164-70.
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2003: Yamashiro Shigeko; Totsukawa Go; Yamakita Yoshihiko; Sasaki Yasuharu; Madaule Pascal; Ishizaki Toshimaa; Narumiya Shuh; Matsumura Fumio
Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II.
Molecular biology of the cell 2003;14(5):1745-56.
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2003: Takemoto-Kimura Sayaka; Terai Hisashi; Takamoto Maki; Ohmae Shogo; Kikumura Shoko; Segi Eri; Arakawa Yoshiki; Furuyashiki Tomoyuki; Narumiya Shuh; Bito Haruhiko
Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).
The Journal of biological chemistry 2003;278(20):18597-605.
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2003: Arakawa Yoshiki; Bito Haruhiko; Furuyashiki Tomoyuki; Tsuji Takahiro; Takemoto-Kimura Sayaka; Kimura Kazuhiro; Nozaki Kazuhiko; Hashimoto Nobuo; Narumiya Shuh
Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons.
The Journal of cell biology 2003;161(2):381-91.
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2003: Minoshima Yukinori; Kawashima Toshiyuki; Hirose Koichi; Tonozuka Yukio; Kawajiri Aie; Bao Ying Chun; Deng Xingming; Tatsuka Masaaki; Narumiya Shuh; May W Stratford; Nosaka Tetsuya; Semba Kentaro; Inoue Takafumi; Satoh Takaya; Inagaki Masaki; Kitamura Toshio
Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis.
Developmental cell 2003;4(4):549-60.
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2003: Faveeuw Christelle; Gosset Philippe; Bureau Fabrice; Angeli Véronique; Hirai Hiroyuki; Maruyama Takayuki; Narumiya Shuh; Capron Monique; Trottein François
Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways.
European journal of immunology 2003;33(4):889-98.
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2003: Matsuoka Yoko; Furuyashiki Tomoyuki; Bito Haruhiko; Ushikubi Fumitaka; Tanaka Yasuhiro; Kobayashi Takuya; Muro Seiji; Satoh Noriko; Kayahara Tetsuro; Higashi Mikito; Mizoguchi Akira; Shichi Hitoshi; Fukuda Yoshihiro; Nakao Kazuwa; Narumiya Shuh
Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4132-7.
-
2003: Massiera Florence; Saint-Marc Perla; Seydoux Josiane; Murata Takahiko; Kobayashi Takuya; Narumiya Shuh; Guesnet Philippe; Amri Ez-Zoubir; Negrel Raymond; Ailhaud Gérard
Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern?
Journal of lipid research 2003;44(2):271-9.
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2003: Amano Hideki; Hayashi Izumi; Endo Hirahito; Kitasato Hidero; Yamashina Shohei; Maruyama Takayuki; Kobayashi Michiyoshi; Satoh Kazutoyo; Narita Masami; Sugimoto Yukihiko; Murata Takahiko; Yoshimura Hirokuni; Narumiya Shuh; Majima Masataka
Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth.
The Journal of experimental medicine 2003;197(2):221-32.
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2002: Furuyashiki Tomoyuki; Arakawa Yoshiki; Takemoto-Kimura Sayaka; Bito Haruhiko; Narumiya Shuh
Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14458-63.
-
2002: Takahashi Yoshimasa; Tokuoka Shota; Masuda Taisei; Hirano Yousuke; Nagao Masafumi; Tanaka Hiroyuki; Inagaki Naoki; Narumiya Shuh; Nagai Hiroichi
Augmentation of allergic inflammation in prostanoid IP receptor deficient mice.
British journal of pharmacology 2002;137(3):315-22.
-
2002: Narumiya Shuh; Mabuchi Issei
Cell biology: spinning actin to divide.
Nature 2002;419(6902):27-8.
-
2002: Kobayashi Takuya; Narumiya Shuh
Function of prostanoid receptors: studies on knockout mice.
Prostaglandins & other lipid mediators 2002;68-69():557-73.
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2002: Makino Hisashi; Tanaka Issei; Mukoyama Masashi; Sugawara Akira; Mori Kiyoshi; Muro Seiji; Suganami Takayoshi; Yahata Kensei; Ishibashi Rieko; Ohuchida Shuichi; Maruyama Takayuki; Narumiya Shuh; Nakao Kazuwa
Prevention of diabetic nephropathy in rats by prostaglandin E receptor EP1-selective antagonist.
Journal of the American Society of Nephrology : JASN 2002;13(7):1757-65.
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2002: Fujino Takayuki; Yuhki Koh-ichi; Yamada Takehiro; Hara Akiyoshi; Takahata Osamu; Okada Yuji; Xiao Chun-Yang; Ma Hong; Karibe Hideji; Iwashima Yasunori; Fukuzawa Jun; Hasebe Naoyuki; Kikuchi Kenjiro; Narumiya Shuh; Ushikubi Fumitaka
Effects of the prostanoids on the proliferation or hypertrophy of cultured murine aortic smooth muscle cells.
British journal of pharmacology 2002;136(4):530-9.
-
2002: Chevrier Véronique; Piel Matthieu; Collomb Nora; Saoudi Yasmina; Frank Ronald; Paintrand Michel; Narumiya Shuh; Bornens Michel; Job Didier
The Rho-associated protein kinase p160ROCK is required for centrosome positioning.
The Journal of cell biology 2002;157(5):807-17.
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2002: Tsuji Takahiro; Ishizaki Toshimasa; Okamoto Muneo; Higashida Chiharu; Kimura Kazuhiro; Furuyashiki Tomoyuki; Arakawa Yoshiki; Birge Raymond B; Nakamoto Tetsuya; Hirai Hisamaru; Narumiya Shuh
ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts.
The Journal of cell biology 2002;157(5):819-30.
-
2002: Ushikubi Fumitaka; Narumiya Shuh
[The roles of the prostanoids played in the body]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2002;119(4):201-7.
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2002: Kabashima Kenji; Saji Tomomi; Murata Takahiko; Nagamachi Miyako; Matsuoka Toshiyuki; Segi Eri; Tsuboi Kazuhito; Sugimoto Yukihiko; Kobayashi Takuya; Miyachi Yoshiki; Ichikawa Atsushi; Narumiya Shuh
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.
The Journal of clinical investigation 2002;109(7):883-93.
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2002: Yoshida Keiji; Oida Hiroji; Kobayashi Takuya; Maruyama Takayuki; Tanaka Masaharu; Katayama Teruaki; Yamaguchi Kojiro; Segi Eri; Tsuboyama Tadao; Matsushita Mutsumi; Ito Kosei; Ito Yoshiaki; Sugimoto Yukihiko; Ushikubi Fumitaka; Ohuchida Shuichi; Kondo Kigen; Nakamura Takashi; Narumiya Shuh
Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4580-5.
-
2002: Seno Hiroshi; Oshima Masanobu; Ishikawa Tomo-o; Oshima Hiroko; Takaku Kazuaki; Chiba Tsutomu; Narumiya Shuh; Taketo Makoto M
Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps.
Cancer research 2002;62(2):506-11.
-
2002: Mutoh Michihiro; Watanabe Kouji; Kitamura Tomohiro; Shoji Yutaka; Takahashi Mami; Kawamori Toshihiko; Tani Kousuke; Kobayashi Michiyoshi; Maruyama Takayuki; Kobayashi Kaoru; Ohuchida Shuichi; Sugimoto Yukihiko; Narumiya Shuh; Sugimura Takashi; Wakabayashi Keiji
Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.
Cancer research 2002;62(1):28-32.
-
2002: Kobayashi Takuya; Narumiya Shuh
Prostanoids in health and disease; lessons from receptor-knockout mice.
Advances in experimental medicine and biology 2002;507():593-7.
-
2001: Belmonte N; Phillips B W; Massiera F; Villageois P; Wdziekonski B; Saint-Marc P; Nichols J; Aubert J; Saeki K; Yuo A; Narumiya S; Ailhaud G; Dani C
Activation of extracellular signal-regulated kinases and CREB/ATF-1 mediate the expression of CCAAT/enhancer binding proteins beta and -delta in preadipocytes.
Molecular endocrinology (Baltimore, Md.) 2001;15(11):2037-49.
-
2001: Rodríguez-Fernández J L; Sánchez-Martín L; Rey M; Vicente-Manzanares M; Narumiya S; Teixidó J; Sánchez-Madrid F; Cabañas C
Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1.
The Journal of biological chemistry 2001;276(44):40518-27.
-
2001: Xiao C Y; Hara A; Yuhki K; Fujino T; Ma H; Okada Y; Takahata O; Yamada T; Murata T; Narumiya S; Ushikubi F
Roles of prostaglandin I(2) and thromboxane A(2) in cardiac ischemia-reperfusion injury: a study using mice lacking their respective receptors.
Circulation 2001;104(18):2210-5.
-
2001: Eda M; Yonemura S; Kato T; Watanabe N; Ishizaki T; Madaule P; Narumiya S
Rho-dependent transfer of Citron-kinase to the cleavage furrow of dividing cells.
Journal of cell science 2001;114(Pt 18):3273-84.
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2001: Mizoguchi A; Eguchi N; Kimura K; Kiyohara Y; Qu W M; Huang Z L; Mochizuki T; Lazarus M; Kobayashi T; Kaneko T; Narumiya S; Urade Y; Hayaishi O
Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11674-9.
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2001: Ma H; Hara A; Xiao C Y; Okada Y; Takahata O; Nakaya K; Sugimoto Y; Ichikawa A; Narumiya S; Ushikubi F
Increased bleeding tendency and decreased susceptibility to thromboembolism in mice lacking the prostaglandin E receptor subtype EP(3).
Circulation 2001;104(10):1176-80.
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2001: Sonoshita M; Takaku K; Sasaki N; Sugimoto Y; Ushikubi F; Narumiya S; Oshima M; Taketo M M
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice.
Nature medicine 2001;7(9):1048-51.
-
2001: Narumiya S; FitzGerald G A
Genetic and pharmacological analysis of prostanoid receptor function.
The Journal of clinical investigation 2001;108(1):25-30.
-
2001: Ueno A; Matsumoto H; Naraba H; Ikeda Y; Ushikubi F; Matsuoka T; Narumiya S; Sugimoto Y; Ichikawa A; Oh-ishi S
Major roles of prostanoid receptors IP and EP(3) in endotoxin-induced enhancement of pain perception.
Biochemical pharmacology 2001;62(2):157-60.
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2001: Minami T; Nakano H; Kobayashi T; Sugimoto Y; Ushikubi F; Ichikawa A; Narumiya S; Ito S
Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice.
British journal of pharmacology 2001;133(3):438-44.
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2001: Shinomiya S; Naraba H; Ueno A; Utsunomiya I; Maruyama T; Ohuchida S; Ushikubi F; Yuki K; Narumiya S; Sugimoto Y; Ichikawa A; Oh-ishi S
Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists.
Biochemical pharmacology 2001;61(9):1153-60.
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2001: Kato T; Watanabe N; Morishima Y; Fujita A; Ishizaki T; Narumiya S
Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells.
Journal of cell science 2001;114(Pt 4):775-84.
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2001: Boku K; Ohno T; Saeki T; Hayashi H; Hayashi I; Katori M; Murata T; Narumiya S; Saigenji K; Majima M
Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves.
Gastroenterology 2001;120(1):134-43.
-
2001: Ishizaki T; Morishima Y; Okamoto M; Furuyashiki T; Kato T; Narumiya S
Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1.
Nature cell biology 2001;3(1):8-14.
-
2001: Honjo M; Tanihara H; Inatani M; Kido N; Sawamura T; Yue B Y; Narumiya S; Honda Y
Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility.
Investigative ophthalmology & visual science 2001;42(1):137-44.
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2000: Sakuma Y; Tanaka K; Suda M; Komatsu Y; Yasoda A; Miura M; Ozasa A; Narumiya S; Sugimoto Y; Ichikawa A; Ushikubi F; Nakao K
Impaired bone resorption by lipopolysaccharide in vivo in mice deficient in the prostaglandin E receptor EP4 subtype.
Infection and immunity 2000;68(12):6819-25.
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2000: Kotani M; Tanaka I; Ogawa Y; Suganami T; Matsumoto T; Muro S; Yamamoto Y; Sugawara A; Yoshimasa Y; Sagawa N; Narumiya S; Nakao K
Multiple signal transduction pathways through two prostaglandin E receptor EP3 subtype isoforms expressed in human uterus.
The Journal of clinical endocrinology and metabolism 2000;85(11):4315-22.
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2000: Okada Y; Hara A; Ma H; Xiao C Y; Takahata O; Kohgo Y; Narumiya S; Ushikubi F
Characterization of prostanoid receptors mediating contraction of the gastric fundus and ileum: studies using mice deficient in prostanoid receptors.
British journal of pharmacology 2000;131(4):745-55.
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2000: Muro S; Tanaka I; Usui T; Kotani M; Koide S; Mukoyama M; Fukata J; Itoh H; Narumiya S; Kawata M; Nakao K
Expression of prostaglandin E receptor EP4 subtype in rat adrenal zona glomerulosa: involvement in aldosterone release.
Endocrine journal 2000;47(4):429-36.
-
2000: Ushikubi F; Sugimoto Y; Ichikawa A; Narumiya S
Roles of prostanoids revealed from studies using mice lacking specific prostanoid receptors.
Japanese journal of pharmacology 2000;83(4):279-85.
-
2000: Watanabe K; Kawamori T; Nakatsugi S; Ohta T; Ohuchida S; Yamamoto H; Maruyama T; Kondo K; Narumiya S; Sugimura T; Wakabayashi K
Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice.
Cancer letters 2000;156(1):57-61.
-
2000: Kobayashi T; Ushikubi F; Narumiya S
Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis.
The Journal of biological chemistry 2000;275(32):24294-303.
-
2000: Sugimoto Y; Narumiya S; Ichikawa A
Distribution and function of prostanoid receptors: studies from knockout mice.
Progress in lipid research 2000;39(4):289-314.
-
2000: Kimura K; Tsuji T; Takada Y; Miki T; Narumiya S
Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation.
The Journal of biological chemistry 2000;275(23):17233-6.
-
2000: Bito H; Furuyashiki T; Ishihara H; Shibasaki Y; Ohashi K; Mizuno K; Maekawa M; Ishizaki T; Narumiya S
A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons.
Neuron 2000;26(2):431-41.
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2000: Ishizaki T; Uehata M; Tamechika I; Keel J; Nonomura K; Maekawa M; Narumiya S
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.
Molecular pharmacology 2000;57(5):976-83.
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2000: Madaule P; Furuyashiki T; Eda M; Bito H; Ishizaki T; Narumiya S
Citron, a Rho target that affects contractility during cytokinesis.
Microscopy research and technique 2000;49(2):123-6.
-
2000: Ushikubi F; Narumiya S
[Analysis of the mice lacking the prostanoid receptor]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(6 Suppl):909-20.
-
2000: Narumiya S
[Signal transduction and therapeutic strategies]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(6 Suppl):827-32.
-
2000: Matsuoka T; Hirata M; Tanaka H; Takahashi Y; Murata T; Kabashima K; Sugimoto Y; Kobayashi T; Ushikubi F; Aze Y; Eguchi N; Urade Y; Yoshida N; Kimura K; Mizoguchi A; Honda Y; Nagai H; Narumiya S
Prostaglandin D2 as a mediator of allergic asthma.
Science (New York, N.Y.) 2000;287(5460):2013-7.
-
2000: Suda M; Tanaka K; Sakuma Y; Yasoda A; Ozasa A; Fukata J; Tanaka I; Narumiya S; Nakao K
Prostaglandin E(2) (PGE(2)) induces the c-fos and c-jun expressions via the EP(1) subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells.
Calcified tissue international 2000;66(3):217-23.
-
2000: Ueno A; Naraba H; Ikeda Y; Ushikubi F; Murata T; Narumiya S; Oh-ishi S
Intrinsic prostacyclin contributes to exudation induced by bradykinin or carrageenin: a study on the paw edema induced in IP-receptor-deficient mice.
Life sciences 2000;66(12):PL155-60.
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2000: Sakuma Y; Tanaka K; Suda M; Yasoda A; Natsui K; Tanaka I; Ushikubi F; Narumiya S; Segi E; Sugimoto Y; Ichikawa A; Nakao K
Crucial involvement of the EP4 subtype of prostaglandin E receptor in osteoclast formation by proinflammatory cytokines and lipopolysaccharide.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(2):218-27.
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2000: Fujita A; Nakamura K; Kato T; Watanabe N; Ishizaki T; Kimura K; Mizoguchi A; Narumiya S
Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella.
Journal of cell science 2000;113 ( Pt 1)():103-12.
-
2000: Narumiya S; Ishizaki T; Uehata M
Use and properties of ROCK-specific inhibitor Y-27632.
Methods in enzymology 2000;325():273-84.
-
1999: Kobayashi T; Ushikubi F; Narumiya S
[Determination of ligand binding domains of the prostanoid receptors]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():127P-129P.
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1999: Narumiya S
[Cellular functions & pharmacological manipulations of the small GTPase Rho & Rho effectors]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():1P-5P.
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1999: Watanabe K; Kawamori T; Nakatsugi S; Ohta T; Ohuchida S; Yamamoto H; Maruyama T; Kondo K; Ushikubi F; Narumiya S; Sugimura T; Wakabayashi K
Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.
Cancer research 1999;59(20):5093-6.
-
1999: Narumiya S; Sugimoto Y; Ushikubi F
Prostanoid receptors: structures, properties, and functions.
Physiological reviews 1999;79(4):1193-226.
-
1999: Shiraishi Y; Mizutani A; Bito H; Fujisawa K; Narumiya S; Mikoshiba K; Furuichi T
Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(19):8389-400.
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1999: Hizaki H; Segi E; Sugimoto Y; Hirose M; Saji T; Ushikubi F; Matsuoka T; Noda Y; Tanaka T; Yoshida N; Narumiya S; Ichikawa A
Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2).
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10501-6.
-
1999: Maekawa M; Ishizaki T; Boku S; Watanabe N; Fujita A; Iwamatsu A; Obinata T; Ohashi K; Mizuno K; Narumiya S
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Science (New York, N.Y.) 1999;285(5429):895-8.
-
1999: Ishibashi R; Tanaka I; Kotani M; Muro S; Goto M; Sugawara A; Mukoyama M; Sugimoto Y; Ichikawa A; Narumiya S; Nakao K
Roles of prostaglandin E receptors in mesangial cells under high-glucose conditions.
Kidney international 1999;56(2):589-600.
-
1999: Watanabe N; Kato T; Fujita A; Ishizaki T; Narumiya S
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization.
Nature cell biology 1999;1(3):136-43.
-
1999: Nakamura K; Fujita A; Murata T; Watanabe G; Mori C; Fujita J; Watanabe N; Ishizaki T; Yoshida O; Narumiya S
Rhophilin, a small GTPase Rho-binding protein, is abundantly expressed in the mouse testis and localized in the principal piece of the sperm tail.
FEBS letters 1999;445(1):9-13.
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1999: Furuyashiki T; Fujisawa K; Fujita A; Madaule P; Uchino S; Mishina M; Bito H; Narumiya S
Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(1):109-18.
-
1999: Ohishi S; Ueno A; Matsumoto H; Murata T; Ushikubi F; Narumiya S
Evidence for involvement of prostaglandin I2 as a major nociceptive mediator in acetic acid-induced writhing reaction: a study using IP-receptor disrupted mice.
Advances in experimental medicine and biology 1999;469():265-8.
-
1998: Ushikubi F; Segi E; Sugimoto Y; Murata T; Matsuoka T; Kobayashi T; Hizaki H; Tuboi K; Katsuyama M; Ichikawa A; Tanaka T; Yoshida N; Narumiya S
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3.
Nature 1998;395(6699):281-4.
-
1998: Madaule P; Eda M; Watanabe N; Fujisawa K; Matsuoka T; Bito H; Ishizaki T; Narumiya S
Role of citron kinase as a target of the small GTPase Rho in cytokinesis.
Nature 1998;394(6692):491-4.
-
1998: Fujisawa K; Madaule P; Ishizaki T; Watanabe G; Bito H; Saito Y; Hall A; Narumiya S
Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules.
The Journal of biological chemistry 1998;273(30):18943-9.
-
1998: Hirose M; Ishizaki T; Watanabe N; Uehata M; Kranenburg O; Moolenaar W H; Matsumura F; Maekawa M; Bito H; Narumiya S
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells.
The Journal of cell biology 1998;141(7):1625-36.
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1998: Yamaguchi M; Nakamoto M; Honda H; Nakagawa T; Fujita H; Nakamura T; Hirai H; Narumiya S; Kakizuka A
Retardation of skeletal development and cervical abnormalities in transgenic mice expressing a dominant-negative retinoic acid receptor in chondrogenic cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7491-6.
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1998: Segi E; Sugimoto Y; Yamasaki A; Aze Y; Oida H; Nishimura T; Murata T; Matsuoka T; Ushikubi F; Hirose M; Tanaka T; Yoshida N; Narumiya S; Ichikawa A
Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice.
Biochemical and biophysical research communications 1998;246(1):7-12.
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1998: Suda M; Tanaka K; Yasoda A; Natsui K; Sakuma Y; Tanaka I; Ushikubi F; Narumiya S; Nakao K
Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells.
Calcified tissue international 1998;62(4):327-31.
-
1998: Sugimoto Y; Segi E; Tsuboi K; Ichikawa A; Narumiya S
Female reproduction in mice lacking the prostaglandin F receptor. Roles of prostaglandin and oxytocin receptors in parturition.
Advances in experimental medicine and biology 1998;449():317-21.
-
1998: Suwa H; Ohshio G; Imamura T; Watanabe G; Arii S; Imamura M; Narumiya S; Hiai H; Fukumoto M
Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.
British journal of cancer 1998;77(1):147-52.
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1997: Oida H; Hirata M; Sugimoto Y; Ushikubi F; Ohishi H; Mizuno N; Ichikawa A; Narumiya S
Expression of messenger RNA for the prostaglandin D receptor in the leptomeninges of the mouse brain.
FEBS letters 1997;417(1):53-6.
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1997: Kiriyama M; Ushikubi F; Kobayashi T; Hirata M; Sugimoto Y; Narumiya S
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
British journal of pharmacology 1997;122(2):217-24.
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1997: Murata T; Ushikubi F; Matsuoka T; Hirata M; Yamasaki A; Sugimoto Y; Ichikawa A; Aze Y; Tanaka T; Yoshida N; Ueno A; Oh-ishi S; Narumiya S
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor.
Nature 1997;388(6643):678-82.
-
1997: Sasaki Y; Takahashi T; Tanaka I; Nakamura K; Okuno Y; Nakagawa O; Narumiya S; Nakao K
Expression of prostacyclin receptor in human megakaryocytes.
Blood 1997;90(3):1039-46.
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1997: Sugimoto Y; Yamasaki A; Segi E; Tsuboi K; Aze Y; Nishimura T; Oida H; Yoshida N; Tanaka T; Katsuyama M; Hasumoto K; Murata T; Hirata M; Ushikubi F; Negishi M; Ichikawa A; Narumiya S
Failure of parturition in mice lacking the prostaglandin F receptor.
Science (New York, N.Y.) 1997;277(5326):681-3.
-
1997: Narumiya S; Ishizaki T; Watanabe N
Rho effectors and reorganization of actin cytoskeleton.
FEBS letters 1997;410(1):68-72.
-
1997: Watanabe N; Madaule P; Reid T; Ishizaki T; Watanabe G; Kakizuka A; Saito Y; Nakao K; Jockusch B M; Narumiya S
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.
The EMBO journal 1997;16(11):3044-56.
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1997: Kobayashi T; Kiriyama M; Hirata T; Hirata M; Ushikubi F; Narumiya S
Identification of domains conferring ligand binding specificity to the prostanoid receptor. Studies on chimeric prostacyclin/prostaglandin D receptors.
The Journal of biological chemistry 1997;272(24):15154-60.
-
1997: Morimoto K; Sugimoto Y; Katsuyama M; Oida H; Tsuboi K; Kishi K; Kinoshita Y; Negishi M; Chiba T; Narumiya S; Ichikawa A
Cellular localization of mRNAs for prostaglandin E receptor subtypes in mouse gastrointestinal tract.
The American journal of physiology 1997;272(3 Pt 1):G681-7.
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1997: Ishizaki T; Naito M; Fujisawa K; Maekawa M; Watanabe N; Saito Y; Narumiya S
p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions.
FEBS letters 1997;404(2-3):118-24.
-
1997: Kotani M; Tanaka I; Ogawa Y; Usui T; Tamura N; Mori K; Narumiya S; Yoshimi T; Nakao K
Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3).
Genomics 1997;40(3):425-34.
-
1997: Narumiya S
Molecular diversity of prostanoid receptors; subtypes and isoforms of prostaglandin E receptor.
Advances in experimental medicine and biology 1997;400A():207-13.
-
1996: Fujisawa K; Fujita A; Ishizaki T; Saito Y; Narumiya S
Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase.
The Journal of biological chemistry 1996;271(38):23022-8.
-
1996: Takebayashi H; Oida H; Fujisawa K; Yamaguchi M; Hikida T; Fukumoto M; Narumiya S; Kakizuka A
Hormone-induced apoptosis by Fas-nuclear receptor fusion proteins: novel biological tools for controlling apoptosis in vivo.
Cancer research 1996;56(18):4164-70.
-
1996: Narumiya S
The small GTPase Rho: cellular functions and signal transduction.
Journal of biochemistry 1996;120(2):215-28.
-
1996: Nakagawa O; Fujisawa K; Ishizaki T; Saito Y; Nakao K; Narumiya S
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice.
FEBS letters 1996;392(2):189-93.
-
1996: Mori K; Tanaka I; Kotani M; Miyaoka F; Sando T; Muro S; Sasaki Y; Nakagawa O; Ogawa Y; Usui T; Ozaki S; Ichikawa A; Narumiya S; Nakao K
Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester.
Journal of molecular medicine (Berlin, Germany) 1996;74(6):333-6.
-
1996: Reid T; Furuyashiki T; Ishizaki T; Watanabe G; Watanabe N; Fujisawa K; Morii N; Madaule P; Narumiya S
Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain.
The Journal of biological chemistry 1996;271(23):13556-60.
-
1996: Ikeda H; Yamaguchi M; Sugai S; Aze Y; Narumiya S; Kakizuka A
Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo.
Nature genetics 1996;13(2):196-202.
-
1996: Suda M; Tanaka K; Natsui K; Usui T; Tanaka I; Fukushima M; Shigeno C; Konishi J; Narumiya S; Ichikawa A; Nakao N
Prostaglandin E receptor subtypes in mouse osteoblastic cell line.
Endocrinology 1996;137(5):1698-705.
-
1996: Ishizaki T; Maekawa M; Fujisawa K; Okawa K; Iwamatsu A; Fujita A; Watanabe N; Saito Y; Kakizuka A; Morii N; Narumiya S
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
The EMBO journal 1996;15(8):1885-93.
-
1996: Momiyama T; Todo N; Sugimoto Y; Ichikawa A; Narumiya S
Membrane depolarization by activation of prostaglandin E receptor EP3 subtype of putative serotonergic neurons in the dorsal raphe nucleus of the rat.
Naunyn-Schmiedeberg's archives of pharmacology 1996;353(4):377-81.
-
1996: Hirata T; Ushikubi F; Kakizuka A; Okuma M; Narumiya S
Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.
The Journal of clinical investigation 1996;97(4):949-56.
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1996: Watanabe G; Saito Y; Madaule P; Ishizaki T; Fujisawa K; Morii N; Mukai H; Ono Y; Kakizuka A; Narumiya S
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho.
Science (New York, N.Y.) 1996;271(5249):645-8.
-
1996: Okuma M; Hirata T; Ushikubi F; Kakizuka A; Narumiya S
Molecular characterization of a dominantly inherited bleeding disorder with impaired platelet responses to thromboxane A2.
Polish journal of pharmacology 1996;48(1):77-82.
-
1996: Narumiya S
Prostanoid receptors and signal transduction.
Progress in brain research 1996;113():231-41.
-
1995: Nakagawa O; Sasaki Y; Tanaka I; Usui T; Sando T; Muro S; Mori K; Itoh H; Yoshimasa T; Narumiya S
Gene expression of prostacyclin receptor in the hypertrophied heart of spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology. Supplement 1995;22(1):S270-2.
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1995: Oida H; Namba T; Sugimoto Y; Ushikubi F; Ohishi H; Ichikawa A; Narumiya S
In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs.
British journal of pharmacology 1995;116(7):2828-37.
-
1995: Sugimoto Y; Negishi M; Ushikubi F; Narumiya S; Ichikawa A
[Molecular structure and function of the prostanoid receptors]
Seikagaku. The Journal of Japanese Biochemical Society 1995;67(12):1351-65.
-
1995: Madaule P; Furuyashiki T; Reid T; Ishizaki T; Watanabe G; Morii N; Narumiya S
A novel partner for the GTP-bound forms of rho and rac.
FEBS letters 1995;377(2):243-8.
-
1995: Kotani M; Tanaka I; Ogawa Y; Usui T; Mori K; Ichikawa A; Narumiya S; Yoshimi T; Nakao K
Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions.
Molecular pharmacology 1995;48(5):869-79.
-
1995: Hirata M; Ushikubi F; Narumiya S
Prostaglandin I receptor and prostaglandin D receptor.
Journal of lipid mediators and cell signalling 1995;12(2-3):393-404.
-
1995: Ushikubi F; Hirata M; Narumiya S
Molecular biology of prostanoid receptors; an overview.
Journal of lipid mediators and cell signalling 1995;12(2-3):343-59.
-
1995: Saito Y; Nemoto Y; Ishizaki T; Watanabe N; Morii N; Narumiya S
Identification of Glu173 as the critical amino acid residue for the ADP-ribosyltransferase activity of Clostridium botulinum C3 exoenzyme.
FEBS letters 1995;371(2):105-9.
-
1995: Katsuyama M; Nishigaki N; Sugimoto Y; Morimoto K; Negishi M; Narumiya S; Ichikawa A
The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysis.
FEBS letters 1995;372(2-3):151-6.
-
1995: Hirakata H; Ushikubi F; Narumiya S; Hatano Y; Nakamura K; Mori K
The effect of inhaled anesthetics on the platelet aggregation and the ligand-binding affinity of the platelet thromboxane A2 receptor.
Anesthesia and analgesia 1995;81(1):114-8.
-
1995: Kumagai N; Morii N; Ishizaki T; Watanabe N; Fujisawa K; Saito Y; Narumiya S
Lysophosphatidic acid-induced activation of protein Ser/Thr kinases in cultured rat 3Y1 fibroblasts. Possible involvement in rho p21-mediated signalling.
FEBS letters 1995;366(1):11-6.
-
1995: Nishigaki N; Negishi M; Honda A; Sugimoto Y; Namba T; Narumiya S; Ichikawa A
Identification of prostaglandin E receptor 'EP2' cloned from mastocytoma cells EP4 subtype.
FEBS letters 1995;364(3):339-41.
-
1995: Ogawa Y; Tanaka I; Inoue M; Yoshitake Y; Isse N; Nakagawa O; Usui T; Itoh H; Yoshimasa T; Narumiya S
Structural organization and chromosomal assignment of the human prostacyclin receptor gene.
Genomics 1995;27(1):142-8.
-
1995: Ishiguro S; Arii S; Monden K; Fujita S; Nakamura T; Niwano M; Harada T; Ushikubi F; Narumiya S; Imamura M
Involvement of thromboxane A2-thromboxane A2 receptor system of the hepatic sinusoid in pathogenesis of cold preservation/reperfusion injury in the rat liver graft.
Transplantation 1995;59(7):957-61.
-
1995: Saitou M; Sugai S; Tanaka T; Shimouchi K; Fuchs E; Narumiya S; Kakizuka A
Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor.
Nature 1995;374(6518):159-62.
-
1995: Negishi M; Sugimoto Y; Namba T; Irie A; Narumiya S; Ichikawa A
Signal transductions of three isoforms of mouse prostaglandin E receptor EP3 subtype.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():255-7.
-
1995: Narumiya S
Structures, properties and distributions of prostanoid receptors.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():17-22.
-
1995: Morii N; Narumiya S
Preparation of native and recombinant Clostridium botulinum C3 ADP-ribosyltransferase and identification of Rho proteins by ADP-ribosylation.
Methods in enzymology 1995;256():196-206.
-
1994: Sasaki Y; Usui T; Tanaka I; Nakagawa O; Sando T; Takahashi T; Namba T; Narumiya S; Nakao K
Cloning and expression of a cDNA for rat prostacyclin receptor.
Biochimica et biophysica acta 1994;1224(3):601-5.
-
1994: Hirata M; Kakizuka A; Aizawa M; Ushikubi F; Narumiya S
Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11192-6.
-
1994: Ushikubi F; Nakamura K; Narumiya S
Functional reconstitution of platelet thromboxane A2 receptors with Gq and Gi2 in phospholipid vesicles.
Molecular pharmacology 1994;46(5):808-16.
-
1994: Narumiya S
Prostanoid receptors. Structure, function, and distribution.
Annals of the New York Academy of Sciences 1994;744():126-38.
-
1994: Hirata T; Kakizuka A; Ushikubi F; Fuse I; Okuma M; Narumiya S
Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.
The Journal of clinical investigation 1994;94(4):1662-7.
-
1994: Nakagawa O; Tanaka I; Usui T; Harada M; Sasaki Y; Itoh H; Yoshimasa T; Namba T; Narumiya S; Nakao K
Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.
Circulation 1994;90(4):1643-7.
-
1994: Sugimoto Y; Shigemoto R; Namba T; Negishi M; Mizuno N; Narumiya S; Ichikawa A
Distribution of the messenger RNA for the prostaglandin E receptor subtype EP3 in the mouse nervous system.
Neuroscience 1994;62(3):919-28.
-
1994: Narumiya S; Morii N
[rho p21 in cell cycle progression]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1994;39(10):1673-7.
-
1994: Saitou M; Narumiya S; Kakizuka A
Alteration of a single amino acid residue in retinoic acid receptor causes dominant-negative phenotype.
The Journal of biological chemistry 1994;269(29):19101-7.
-
1994: Sugimoto Y; Namba T; Shigemoto R; Negishi M; Ichikawa A; Narumiya S
Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney.
The American journal of physiology 1994;266(5 Pt 2):F823-8.
-
1994: Sando T; Usui T; Tanaka I; Mori K; Sasaki Y; Fukuda Y; Namba T; Sugimoto Y; Ichikawa A; Narumiya S
Molecular cloning and expression of rat prostaglandin E receptor EP2 subtype.
Biochemical and biophysical research communications 1994;200(3):1329-33.
-
1994: Katsuyama M; Sugimoto Y; Namba T; Irie A; Negishi M; Narumiya S; Ichikawa A
Cloning and expression of a cDNA for the human prostacyclin receptor.
FEBS letters 1994;344(1):74-8.
-
1994: Namba T; Oida H; Sugimoto Y; Kakizuka A; Negishi M; Ichikawa A; Narumiya S
cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla.
The Journal of biological chemistry 1994;269(13):9986-92.
-
1994: Sugimoto Y; Hasumoto K; Namba T; Irie A; Katsuyama M; Negishi M; Kakizuka A; Narumiya S; Ichikawa A
Cloning and expression of a cDNA for mouse prostaglandin F receptor.
The Journal of biological chemistry 1994;269(2):1356-60.
-
1993: Negishi M; Namba T; Sugimoto Y; Irie A; Katada T; Narumiya S; Ichikawa A
Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o).
The Journal of biological chemistry 1993;268(35):26067-70.
-
1993: Morii N; Kumagai N; Nur-E-Kamal M S; Narumiya S; Maruta H
rho GAP of 28 kDa (GAP2), but not of 190 kDa (p190), requires Asp65 and Asp67 of rho GTPase for its activation.
The Journal of biological chemistry 1993;268(36):27160-3.
-
1993: Ushikubi F; Aiba Y; Nakamura K; Namba T; Hirata M; Mazda O; Katsura Y; Narumiya S
Thromboxane A2 receptor is highly expressed in mouse immature thymocytes and mediates DNA fragmentation and apoptosis.
The Journal of experimental medicine 1993;178(5):1825-30.
-
1993: Nüsing R M; Hirata M; Kakizuka A; Eki T; Ozawa K; Narumiya S
Characterization and chromosomal mapping of the human thromboxane A2 receptor gene.
The Journal of biological chemistry 1993;268(33):25253-9.
-
1993: Kumagai N; Morii N; Fujisawa K; Nemoto Y; Narumiya S
ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.
The Journal of biological chemistry 1993;268(33):24535-8.
-
1993: Irie A; Sugimoto Y; Namba T; Harazono A; Honda A; Watabe A; Negishi M; Narumiya S; Ichikawa A
Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase.
European journal of biochemistry / FEBS 1993;217(1):313-8.
-
1993: Namba T; Sugimoto Y; Negishi M; Irie A; Ushikubi F; Kakizuka A; Ito S; Ichikawa A; Narumiya S
Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity.
Nature 1993;365(6442):166-70.
-
1993: Watabe A; Sugimoto Y; Honda A; Irie A; Namba T; Negishi M; Ito S; Narumiya S; Ichikawa A
Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor.
The Journal of biological chemistry 1993;268(27):20175-8.
-
1993: Nishigaki N; Negishi M; Sugimoto Y; Namba T; Narumiya S; Ichikawa A
Characterization of the prostaglandin E receptor expressed on a cultured mast cell line, BNu-2cl3.
Biochemical pharmacology 1993;46(5):863-9.
-
1993: Kumagai N; Morii N; Fujisawa K; Yoshimasa T; Nakao K; Narumiya S
Lysophosphatidic acid induces tyrosine phosphorylation and activation of MAP-kinase and focal adhesion kinase in cultured Swiss 3T3 cells.
FEBS letters 1993;329(3):273-6.
-
1993: Yamamoto M; Marui N; Sakai T; Morii N; Kozaki S; Ikai K; Imamura S; Narumiya S
ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle.
Oncogene 1993;8(6):1449-55.
-
1993: Hirata M; Ushikubi F; Narumiya S
[Structure and function of the prostanoid receptors in cardiovascular system]
Nippon rinsho. Japanese journal of clinical medicine 1993;51(6):1586-90.
-
1993: Kita T; Yokode M; Arai H; Iiyama M; Ueda Y; Ueyama K; Narumiya S
Cigarette smoke, LDL and cholesteryl ester accumulation in macrophages. Implications for atherosclerosis.
Annals of the New York Academy of Sciences 1993;686():91-6; discussion 97-8.
-
1993: Negishi M; Sugimoto Y; Irie A; Narumiya S; Ichikawa A
Two isoforms of prostaglandin E receptor EP3 subtype. Different COOH-terminal domains determine sensitivity to agonist-induced desensitization.
The Journal of biological chemistry 1993;268(13):9517-21.
-
1993: Honda A; Sugimoto Y; Namba T; Watabe A; Irie A; Negishi M; Narumiya S; Ichikawa A
Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype.
The Journal of biological chemistry 1993;268(11):7759-62.
-
1993: Narumiya S; Hirata N; Namba T; Hayashi Y; Ushikubi F; Sugimoto Y; Negishi M; Ichikawa A
Structure and function of prostanoid receptors.
Journal of lipid mediators 1993;6(1-3):155-61.
-
1993: Tominaga T; Sugie K; Hirata M; Morii N; Fukata J; Uchida A; Imura H; Narumiya S
Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho.
The Journal of cell biology 1993;120(6):1529-37.
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1993: Negishi M; Sugimoto Y; Hayashi Y; Namba T; Honda A; Watabe A; Narumiya S; Ichikawa A
Functional interaction of prostaglandin E receptor EP3 subtype with guanine nucleotide-binding proteins, showing low-affinity ligand binding.
Biochimica et biophysica acta 1993;1175(3):343-50.
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1993: Sugimoto Y; Negishi M; Hayashi Y; Namba T; Honda A; Watabe A; Hirata M; Narumiya S; Ichikawa A
Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins.
The Journal of biological chemistry 1993;268(4):2712-8.
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1993: Narumiya S; Morii N
rho gene products, botulinum C3 exoenzyme and cell adhesion.
Cellular signalling 1993;5(1):9-19.
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1993: Namba T; Narumiya S
[Thromboxane A2 receptor; structure, function and tissue distribution]
Nippon rinsho. Japanese journal of clinical medicine 1993;51(1):233-40.
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1992: Arai H; Nagano Y; Narumiya S; Kita T
Decreased arachidonate metabolism in mouse peritoneal macrophages after foam cell transformation with oxidized low-density lipoproteins.
Journal of biochemistry 1992;112(4):482-7.
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1992: Morii N; Teru-uchi T; Tominaga T; Kumagai N; Kozaki S; Ushikubi F; Narumiya S
A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation.
The Journal of biological chemistry 1992;267(29):20921-6.
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1992: Nemoto Y; Namba T; Teru-uchi T; Ushikubi F; Morii N; Narumiya S
A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein.
The Journal of biological chemistry 1992;267(29):20916-20.
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1992: Namba T; Sugimoto Y; Hirata M; Hayashi Y; Honda A; Watabe A; Negishi M; Ichikawa A; Narumiya S
Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis.
Biochemical and biophysical research communications 1992;184(3):1197-203.
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1992: Morii N; Narumiya S
[ras oncogene-related small molecular weight GTP-binding protein, rho gene product and botulinum C3 ADP-ribosyltransferase]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1992;99(4):191-203.
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1992: Sugimoto Y; Namba T; Honda A; Hayashi Y; Negishi M; Ichikawa A; Narumiya S
Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype.
The Journal of biological chemistry 1992;267(10):6463-6.
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1992: Ushikubi F; Hirata M; Narumiya S; Okuma M
[Platelet thromboxane A2 receptor]
Nippon rinsho. Japanese journal of clinical medicine 1992;50(2):264-8.
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1992: Ushikubi F; Ishibashi T; Narumiya S; Okuma M
Analysis of the defective signal transduction mechanism through the platelet thromboxane A2 receptor in a patient with polycythemia vera.
Thrombosis and haemostasis 1992;67(1):144-6.
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1991: Nemoto Y; Namba T; Kozaki S; Narumiya S
Clostridium botulinum C3 ADP-ribosyltransferase gene. Cloning, sequencing, and expression of a functional protein in Escherichia coli.
The Journal of biological chemistry 1991;266(29):19312-9.
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1991: Morii N; Kawano K; Sekine A; Yamada T; Narumiya S
Purification of GTPase-activating protein specific for the rho gene products.
The Journal of biological chemistry 1991;266(12):7646-50.
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1991: Hirata M; Hayashi Y; Ushikubi F; Yokota Y; Kageyama R; Nakanishi S; Narumiya S
Cloning and expression of cDNA for a human thromboxane A2 receptor.
Nature 1991;349(6310):617-20.
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1991: Narumiya S; Ushikubi F; Nakajima M; Hirata M; Okuma M
Purification and characterization of the human platelet TXA2/PGH2 receptor.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():339-46.
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1990: Nishiki T; Matsuda H; Hiroi T; Kamata Y; Kozaki S; Narumiya S; Sakaguchi G
Morphological effects of Clostridium botulinum C3 exoenzyme on cultured cells.
Japanese journal of medical science & biology 1990;43(6):261-2.
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1990: Morii N; Ohashi Y; Nemoto Y; Fujiwara M; Ohnishi Y; Nishiki T; Kamata Y; Kozaki S; Narumiya S; Sakaguchi G
Immunochemical identification of the ADP-ribosyltransferase in botulinum C1 neurotoxin as C3 exoenzyme-like molecule.
Journal of biochemistry 1990;107(5):769-75.
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1990: Nishiki T; Narumiya S; Morii N; Yamamoto M; Fujiwara M; Kamata Y; Sakaguchi G; Kozaki S
ADP-ribosylation of the rho/rac proteins induces growth inhibition, neurite outgrowth and acetylcholine esterase in cultured PC-12 cells.
Biochemical and biophysical research communications 1990;167(1):265-72.
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1990: Narumiya S; Morii N; Sekine A; Kozaki S
ADP-ribosylation of the rho/rac gene products by botulinum ADP-ribosyltransferase: identity of the enzyme and effects on protein and cell functions.
Journal de physiologie 1990;84(4):267-72.
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1989: Ushikubi F; Nakajima M; Hirata M; Okuma M; Fujiwara M; Narumiya S
Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets.
The Journal of biological chemistry 1989;264(28):16496-501.
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1989: Ogorochi T; Nemoto Y; Nakajima M; Nakamura E; Fujiwara M; Narumiya S
cDNA cloning of Gb, the substrate for botulinum ADP-ribosyltransferase from bovine adrenal gland and its identification as a rho gene product.
Biochemical and biophysical research communications 1989;163(2):1175-81.
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1989: Mikami A; Imoto K; Tanabe T; Niidome T; Mori Y; Takeshima H; Narumiya S; Numa S
Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel.
Nature 1989;340(6230):230-3.
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1989: Sekine A; Fujiwara M; Narumiya S
Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase.
The Journal of biological chemistry 1989;264(15):8602-5.
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1989: Arai H; Kita T; Yokode M; Narumiya S; Kawai C
Multiple receptors for modified low density lipoproteins in mouse peritoneal macrophages: different uptake mechanisms for acetylated and oxidized low density lipoproteins.
Biochemical and biophysical research communications 1989;159(3):1375-82.
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1989: Nakajima M; Yamamoto M; Ushikubi F; Okuma M; Fujiwara M; Narumiya S
Expression of thromboxane A2 receptor in cultured human erythroleukemia cells and its induction by 12-O-tetradecanoylphorbol-13-acetate.
Biochemical and biophysical research communications 1989;158(3):958-65.
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1989: Ushikubi F; Nakajima M; Yamamoto M; Ohtsu K; Kimura Y; Okuma M; Uchino H; Fujiwara M; Narumiya S
[3H]S-145 and [125I]I-S-145-OH: new radioligands for platelet thromboxane A2 receptor with low nonspecific binding and high binding affinity for various receptor preparations.
Eicosanoids 1989;2(1):21-7.
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1989: Narumiya S; Ohno K; Fukushima M; Fujiwara M
Cyclopentenone prostaglandins block cell cycle progression in the G1 phase and induce the G1-specific proteins in HeLa S3 cells.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():411-4.
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1988: Ohno K; Fukushima M; Fujiwara M; Narumiya S
Induction of 68,000-dalton heat shock proteins by cyclopentenone prostaglandins. Its association with prostaglandin-induced G1 block in cell cycle progression.
The Journal of biological chemistry 1988;263(36):19764-70.
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1988: Narumiya S; Sekine A; Fujiwara M
Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product.
The Journal of biological chemistry 1988;263(33):17255-7.
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1988: Morii N; Sekine A; Ohashi Y; Nakao K; Imura H; Fujiwara M; Narumiya S
Purification and properties of the cytosolic substrate for botulinum ADP-ribosyltransferase. Identification as an Mr 22,000 guanine nucleotide-binding protein.
The Journal of biological chemistry 1988;263(25):12420-6.
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1988: Kita T; Nagano Y; Yokode M; Ishii K; Kume N; Narumiya S; Kawai C
Prevention of atherosclerotic progression in Watanabe rabbits by probucol.
The American journal of cardiology 1988;62(3):13B-19B.
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1988: Ohno K; Sakai T; Fukushima M; Narumiya S; Fujiwara M
Site and mechanism of growth inhibition by prostaglandins. IV. Effect of cyclopentenone prostaglandins on cell cycle progression of G1-enriched HeLa S3 cells.
The Journal of pharmacology and experimental therapeutics 1988;245(1):294-8.
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1988: Yokode M; Kita T; Arai H; Kawai C; Narumiya S; Fujiwara M
Cholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2344-8.
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1988: Yokode M; Kita T; Kikawa Y; Ogorochi T; Narumiya S; Kawai C
Stimulated arachidonate metabolism during foam cell transformation of mouse peritoneal macrophages with oxidized low density lipoprotein.
The Journal of clinical investigation 1988;81(3):720-9.
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1988: Narumiya S; Morii N; Ohno K; Ohashi Y; Fujiwara M
Subcellular distribution and isoelectric heterogeneity of the substrate for ADP-ribosyl transferase from Clostridium botulinum.
Biochemical and biophysical research communications 1988;150(3):1122-30.
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1987: Narumiya S; Fukushima M
Active transport and cellular accumulation of cyclopentenone prostaglandins: a mechanism of prostaglandin-induced growth inhibition.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17B():972-5.
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1987: Yokode M; Kita T; Narumiya S; Kawai C
Arachidonate metabolism during foam cell transformation of macrophages.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17A():229-32.
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