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Shuh Narumiya

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Sadanori Watanabe; Tihana De Zan; Toshimasa Ishizaki; Shuh Narumiya
Citron kinase mediates transition from constriction to abscission through its coiled-coil domain.
Chengcan Yao; Takako Hirata; Xiaojun Ma; Kitipong Soontrapa; Hiroshi Takemori; Shuh Narumiya
Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.
Chiharu Higashida; Tai Kiuchi; Masahiro Maruoka; Hiroaki Mizuno; Kensaku Mizuno; Shuh Narumiya; Yushi Akiba; Naoki Watanabe
F- and G-actin homeostasis regulates mechanosensitive actin nucleation by formins.

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2013: Sadanori Watanabe; Tihana De Zan; Toshimasa Ishizaki; Shuh Narumiya
Citron kinase mediates transition from constriction to abscission through its coiled-coil domain.
Journal of cell science 2013;126(Pt 8):1773-84.
2013: Chengcan Yao; Takako Hirata; Xiaojun Ma; Kitipong Soontrapa; Hiroshi Takemori; Shuh Narumiya
Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.
Nature communications 2013;4():1685.
2013: Chiharu Higashida; Tai Kiuchi; Masahiro Maruoka; Hiroaki Mizuno; Kensaku Mizuno; Shuh Narumiya; Yushi Akiba; Naoki Watanabe
F- and G-actin homeostasis regulates mechanosensitive actin nucleation by formins.
Nature cell biology 2013;15(4):395-405.
2013: Abdullah Shafique Ahmad; Takayuki Maruyama; Shuh Narumiya; Sylvain Doré
PGE2 EP1 receptor deletion attenuates 6-OHDA-induced Parkinsonism in mice: old switch, new target.
Neurotoxicity research 2013;23(3):260-6.
2013: Takahisa Murata; Takayuki Nakagawa; Masataka Nakamura; Shuh Narumiya; Kosuke Aritake; Hiroyuki Hirai; Masatoshi Hori; Toshihiko Maruyama; Yoshiki Tsubosaka; Yoshihiro Urade; Hiroshi Ozaki
Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(13):5205-10.
2013: Yoshiko Matsumoto Ikushima; Shuh Narumiya; Fumio Arai; Tomoyuki Furuyashiki; Kentaro Hosokawa; Keiyo Takubo; Hirofumi Toyama; Toshio Suda
Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.
Blood 2013;121(11):1995-2007.
2013: Koji Kobayashi; Shuh Narumiya; Hiroshi Ozaki; Yoshiki Tsubosaka; Masatoshi Hori; Takahisa Murata
Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(3):565-71.
2012: Antje Pöschke; Hermann Pavenstädt; Boye L Jensen; Niklas Kern; Takayuki Maruyama; Shuh Narumiya; Rolf M Nüsing
The PGE(2)-EP4 receptor is necessary for stimulation of the renin-angiotensin-aldosterone system in response to low dietary salt intake in vivo.
American journal of physiology. Renal physiology 2012;303(10):F1435-42.
2012: Takako Hirata; Masayuki Miyasaka; Akira Nomachi; K Tohya; Sachiko Tsukita; Takeshi Watanabe; Shuh Narumiya
Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis.
International immunology 2012;24(11):705-17.
2012: Yun Tai Kim; Takayuki Maruyama; Sang-Kwan Moon; Shuh Narumiya; Sylvain Doré
Prostaglandin FP receptor inhibitor reduces ischemic brain damage and neurotoxicity.
Neurobiology of disease 2012;48(1):58-65.
2012: Gehua Zhen; Peter Dobrowolski; Nidhi Kapoor; Yun Tai Kim; John Langer; Rung-chi Li; Takayuki Maruyama; Shuh Narumiya; Jennifer Yocum; Sylvain Dore
PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease.
Neurobiology of aging 2012;33(9):2215-9.
2012: Kentaro Kaneko; Michael Lazarus; Chihiro Miyamoto; Nanae Nagata; Shuh Narumiya; Yo Oishi; Yoshihiro Urade; Shuzhang Yang; Masaaki Yoshikawa; Kosuke Aritake; Tomoyuki Furuyashiki; Kousaku Ohinata
Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice.
Molecular nutrition & food research 2012;56(8):1315-23.
2012: Kojiro Imai; Yoko Ikeda; Kazuhiko Mori; Shuh Narumiya; Toru Oga; Katsuhiko Shinomiya; Morio Ueno; Mayumi Ueta; Norihiko Yokoi; Shigeru Kinoshita
Expression of prostaglandin F receptor in scleral and subconjunctival tissue.
The British journal of ophthalmology 2012;96(8):1148-9.
2012: Stefanie Frölich; Niklas Kern; Shuh Narumiya; Anke Olliges; Yannik Schreiber; Rolf M Nüsing
Temporal expression of the PGE2 synthetic system in the kidney is associated with the time frame of renal developmental vulnerability to cyclooxygenase-2 inhibition.
American journal of physiology. Renal physiology 2012;303(2):F209-19.
2012: Antje Vennemann; Nerea Ferreiros Bouzas; Anemone Gerstner; Niklas Kern; Takayuki Maruyama; Shuh Narumiya; Rolf M Nüsing
PTGS-2-PTGER2/4 signaling pathway partially protects from diabetogenic toxicity of streptozotocin in mice.
Diabetes 2012;61(7):1879-87.
2012: Naoki Nakagawa; Shuh Narumiya; Yukihiko Sugimoto; Osamu Takahata; Koh-ichi Yuhki; Kazutoshi Abe; Takayuki Fujino; Naoyuki Hasebe; Maki Kabara; Hitoshi Kashiwagi; Jun-ichi Kawabe; Kenjiro Kikuchi; Fumiaki Kojima; Fumitaka Ushikubi
The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice.
Kidney international 2012;82(2):158-71.
2012: Tomohiro Aoki; Shuh Narumiya
Prostaglandins and chronic inflammation.
Trends in pharmacological sciences 2012;33(6):304-11.
2012: Mayumi Ueta; Shizuo Akira; Tsutomu Inatomi; Toshiyuki Matsuoka; Shuh Narumiya; Hiromi Sawai; Chie Sotozono; Gen Tamiya; Kei Tashiro; Katsushi Tokunaga; Masao Ueki; Shigeru Kinoshita
Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes.
The Journal of allergy and clinical immunology 2012;129(5):1413-1416.e11.
2012: Yoshio Matsui; Masaki Nakamura; Shuh Narumiya; Fumihiro Ogawa; Yukitoshi Satoh; Tastunori Suzuki; Hideki Amano; Koji Eshima; Yoshiya Ito; Akira Iyoda; Shintaro Kato; Hidero Kitasato; Masataka Majima
Thromboxane A₂ receptor signaling facilitates tumor colonization through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells.
Cancer science 2012;103(4):700-7.
2012: Kohei Tanaka; Eri Segi-Nishida; Yuta Senzai; Matthew D Breyer; Richard M Breyer; Yuichi Deguchi; Tomoyuki Furuyashiki; Yuki Imoto; Shiho Kitaoka; Shuh Narumiya
Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(12):4319-29.
2012: Ryota Shinohara; Hirohide Takebayashi; Dean Thumkeo; Keisuke Watanabe; Tomoyuki Furuyashiki; Toshimasa Ishizaki; Hiroshi Kamijo; Naoko Kaneko; Hiroshi Kiyonari; Kazunobu Sawamoto; Shuh Narumiya
A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.
Nature neuroscience 2012;15(3):373-80, S1-2.
2012: Kiyomi Hamaguchi; Takayuki Nakagawa; Shuh Narumiya; Norio Yamamoto; Tomoyuki Furuyashiki; Juichi Ito
Role of PGE-type receptor 4 in auditory function and noise-induced hearing loss in mice.
Neuropharmacology 2012;62(4):1841-7.
2012: Tsuyoshi Tajima; Yoshihiro Urade; Kosuke Aritake; Toshiyuki Matsuoka; Masaki Michishita; Takahisa Murata; Shuh Narumiya; Hiroshi Ozaki; Masatoshi Hori
EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals.
American journal of physiology. Gastrointestinal and liver physiology 2012;302(5):G524-34.
2012: Tatsuya Hoshino; Takahide Matsushima; Naoya Murao; Takushi Namba; Shuh Narumiya; Yukihiko Sugimoto; Toshiharu Suzuki; Masaya Takehara; Tohru Mizushima
Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor.
Journal of neurochemistry 2012;120(5):795-805.
2012: Tsutomu Minamino; Shuh Narumiya; Hirotoki Ohkubo; Hiroyuki Sakagami; Takehito Sato; Akitaka Shibuya; Tatsunori Suzuki; Takako Ae; Kanako Hosono; Yoshiya Ito; Wasaburo Koizumi; Masataka Majima
Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment.
Toxicology and applied pharmacology 2012;259(1):104-14.
2012: Takako Hirata; Shuh Narumiya
Prostanoids as regulators of innate and adaptive immunity.
Advances in immunology 2012;116():143-74.
2012: Yiru Guo; Steven P Jones; Qianhong Li; Shuh Narumiya; Gregg Rokosh; Wei Tan; Deepali Nivas Tukaye; Wen-Jian Wu; Xiaoping Zhu; Michael Book; Roberto Bolli
The COX-2/PGI2 receptor axis plays an obligatory role in mediating the cardioprotection conferred by the late phase of ischemic preconditioning.
PloS one 2012;7(7):e41178.
2012: Satoko Sakamoto; Naoki Watanabe; Sadanori Watanabe; Takatoshi Arakawa; Toshimasa Ishizaki; Katsuya Okawa; Shuh Narumiya
Liprin-α controls stress fiber formation by binding to mDia and regulating its membrane localization.
Journal of cell science 2012;125(Pt 1):108-20.
2011: Takako Hirata; Shuh Narumiya
Prostanoid receptors.
Chemical reviews 2011;111(10):6209-30.
2011: Hiroshi Kamijo; Seiichi Koike; Masayuki Masu; Yutaka Matsumura; Yoshihiko Shimizu; Dean Thumkeo; Toshimasa Ishizaki; Shuh Narumiya
Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II.
Genes to cells : devoted to molecular & cellular mechanisms 2011;16(10):1012-21.
2011: Yuri Ikeda-Matsuo; Shuh Narumiya; Hayato Tanji; Yasuharu Sasaki
Inhibition of prostaglandin E2 EP3 receptors improves stroke injury via anti-inflammatory and anti-apoptotic mechanisms.
Journal of neuroimmunology 2011;238(1-2):34-43.
2011: Tomoyuki Mitsumori; Toshihiko Momiyama; Akinori Nishi; Takahide Shuto; Fumitaka Ushikubi; Tomohiro Aoki; Tomoyuki Furuyashiki; Takashi Hayakawa; Haruhisa Inoue; Shiho Kitaoka; Toshiyuki Matsuoka; Shuh Narumiya
Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake.
The European journal of neuroscience 2011;34(4):594-604.
2011: Chihiro Suzuki; Tomoyuki Furuyashiki; Chihiro Miyamoto; Shuh Narumiya; Kousaku Ohinata
Central PGE2 exhibits anxiolytic-like activity via EP1 and EP4 receptors in a manner dependent on serotonin 5-HT1A, dopamine D1 and GABAA receptors.
FEBS letters 2011;585(14):2357-62.
2011: Yoshihiro Yamamoto; Hiroo Yokozeki; Yoshihiro Urade; Kosuke Aritake; Hiroyuki Hirai; Kinya Nagata; Masataka Nakamura; Shuh Narumiya; Shinobu Otani; Takahiro Satoh
Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
The American journal of pathology 2011;179(1):302-14.
2011: T Aoki; Tomoyuki Furuyashiki; N Hashimoto; Rieko Ishibashi; A Ishibazawa; H Kataoka; S Kitaoka; Toshiyuki Matsuoka; S Miyamoto; R Morishita; M Nishimura; K Nozaki; K Yamamoto; J Ando; Shuh Narumiya
PGE(2) -EP(2) signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB.
British journal of pharmacology 2011;163(6):1237-49.
2011: Torbjörn Johansson; Shuh Narumiya; Hanns Ulrich Zeilhofer
Contribution of peripheral versus central EP1 prostaglandin receptors to inflammatory pain.
Neuroscience letters 2011;495(2):98-101.
2011: Kanako Hosono; Tatsunori Suzuki; Hideaki Tamaki; Hiroyuki Sakagami; Izumi Hayashi; Shuh Narumiya; Kari Alitalo; Masataka Majima
Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(5):1049-58.
2011: Kitipong Soontrapa; Tetsuya Honda; Daiji Sakata; Chengcan Yao; Takako Hirata; Shohei Hori; Toshiyuki Matsuoka; Yoshihiro Kita; Takao Shimizu; Kenji Kabashima; Shuh Narumiya
Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(16):6668-73.
2011: Shuh Narumiya; Tomoyuki Furuyashiki
Fever, inflammation, pain and beyond: prostanoid receptor research during these 25 years.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(3):813-8.
2011: Tomoyuki Furuyashiki; Shuh Narumiya
Stress responses: the contribution of prostaglandin E(2) and its receptors.
Nature reviews. Endocrinology 2011;7(3):163-75.
2011: Koh-ichi Yuhki; Fumiaki Kojima; Hitoshi Kashiwagi; Jun-ichi Kawabe; Takayuki Fujino; Shuh Narumiya; Fumitaka Ushikubi
Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies.
Pharmacology & therapeutics 2011;129(2):195-205.
2011: Hiroaki Mizuno; Chiharu Higashida; Yunfeng Yuan; Toshimasa Ishizaki; Shuh Narumiya; Naoki Watanabe
Rotational movement of the formin mDia1 along the double helical strand of an actin filament.
Science (New York, N.Y.) 2011;331(6013):80-3.
2011: Dean Thumkeo; Kiyoshi Tohyama; Yosuke Toyoda; Keisuke Watanabe; Tomoyuki Furuyashiki; Toshimasa Ishizaki; Ryota Shinohara; Hirohide Takebayashi; Shuh Narumiya
Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.
PloS one 2011;6(9):e25465.
2010: Hideaki Tanizaki; Gyohei Egawa; Kayo Inaba; Tetsuya Honda; Saeko Nakajima; Catharina Sagita Moniaga; Atsushi Otsuka; Toshimasa Ishizaki; Michio Tomura; Takeshi Watanabe; Yoshiki Miyachi; Shuh Narumiya; Takaharu Okada; Kenji Kabashima
Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells.
Blood 2010;116(26):5875-84.
2010: Sumito Mizuguchi; Takashi Ohno; Youichiro Hattori; Takako Ae; Tsutomu Minamino; Takehito Satoh; Katsuharu Arai; Takeo Saeki; Izumi Hayashi; Yukihiko Sugimoto; Shuh Narumiya; Katsunori Saigenji; Masataka Majima
Roles of prostaglandin E2-EP1 receptor signaling in regulation of gastric motor activity and emptying.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(5):G1078-86.
2010: Masahiro Tanji; Toshimasa Ishizaki; Saman Ebrahimi; Yuko Tsuboguchi; Taiko Sukezane; Tsuyoshi Akagi; Margaret C Frame; Nobuo Hashimoto; Susumu Miyamoto; Shuh Narumiya
mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion.
Molecular and cellular biology 2010;30(19):4604-15.
2010: Shuhko Kuriyama; Hitoshi Kashiwagi; Koh-ichi Yuhki; Fumiaki Kojima; Takehiro Yamada; Takayuki Fujino; Akiyoshi Hara; Koji Takayama; Takayuki Maruyama; Akitoshi Yoshida; Shuh Narumiya; Fumitaka Ushikubi
Selective activation of the prostaglandin E2 receptor subtype EP2 or EP4 leads to inhibition of platelet aggregation.
Thrombosis and haemostasis 2010;104(4):796-803.
2010: Sofiyan Saleem; Zahoor Shah; T Maruyama; Shuh Narumiya; Sylvain Dore
Neuroprotective properties of prostaglandin I2 IP receptor in focal cerebral ischemia.
Neuroscience 2010;170(1):317-23.
2010: Sadanori Watanabe; Katsuya Okawa; Takashi Miki; Satoko Sakamoto; Tomoko Morinaga; Kohei Segawa; Takatoshi Arakawa; Makoto Kinoshita; Toshimasa Ishizaki; Shuh Narumiya
Rho and anillin-dependent control of mDia2 localization and function in cytokinesis.
Molecular biology of the cell 2010;21(18):3193-204.
2010: Abdullah Shafique Ahmad; Muzamil Ahmad; Takayuki Maruyama; Shuh Narumiya; Sylvain Dore
Prostaglandin D2 DP1 receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice.
Age (Dordrecht, Netherlands) 2010;32(3):271-82.
2010: Masatoshi Ohgushi; Michiru Matsumura; Mototsugu Eiraku; Kazuhiro Murakami; Toshihiro Aramaki; Ayaka Nishiyama; Keiko Muguruma; Tokushige Nakano; Hidetaka Suga; Morio Ueno; Toshimasa Ishizaki; Hirofumi Suemori; Shuh Narumiya; Hitoshi Niwa; Yoshiki Sasai
Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells.
Cell stem cell 2010;7(2):225-39.
2010: Daiji Sakata; Chengcan Yao; Shuh Narumiya
Emerging roles of prostanoids in T cell-mediated immunity.
IUBMB life 2010;62(8):591-6.
2010: Elsa C Chan; Gregory J Dusting; Nancy Guo; Hitesh M Peshavariya; Caroline J Taylor; Rodney Dilley; Shuh Narumiya; Fan Jiang
Prostacyclin receptor suppresses cardiac fibrosis: role of CREB phosphorylation.
Journal of molecular and cellular cardiology 2010;49(2):176-85.
2010: Yoshiyasu Esaki; Youxian Li; Daiji Sakata; Chengcan Yao; Eri Segi-Nishida; Toshiyuki Matsuoka; Kazuhiko Fukuda; Shuh Narumiya
Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(27):12233-8.
2010: Shigero Tamba; Rieko Yodoi; K Morimoto; Tomoaki Inazumi; Mamiko Sukeno; Eri Segi-Nishida; Yasushi Okuno; Gozoh Tsujimoto; Shuh Narumiya; Yukihiko Sugimoto
Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling.
Biochimie 2010;92(6):665-75.
2010: Saeko Nakajima; Tetsuya Honda; Daiji Sakata; Gyohei Egawa; Hideaki Tanizaki; Atsushi Otsuka; Catharina Sagita Moniaga; Takeshi Watanabe; Yoshiki Miyachi; Shuh Narumiya; Kenji Kabashima
Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(10):5595-603.
2010: Hiroshi Nakase; Yoshihide Fujiyama; Nobuhide Oshitani; Toru Oga; Kimiko Nonomura; Toshiyuki Matsuoka; Yoshiyasu Esaki; Toshinori Murayama; Satoshi Teramukai; Tsutomu Chiba; Shuh Narumiya
Effect of EP4 agonist (ONO-4819CD) for patients with mild to moderate ulcerative colitis refractory to 5-aminosalicylates: a randomized phase II, placebo-controlled trial.
Inflammatory bowel diseases 2010;16(5):731-3.
2010: Hiroshi Katoh; Kanako Hosono; Yoshiya Ito; Tatsunori Suzuki; Yasufumi Ogawa; Hidefumi Kubo; Hiroki Kamata; Toshiaki Mishima; Hideaki Tamaki; Hiroyuki Sakagami; Yukihiko Sugimoto; Shuh Narumiya; Masahiko Watanabe; Masataka Majima
COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems.
The American journal of pathology 2010;176(3):1469-83.
2010: Jun-Ichi Kawabe; Koh-Ichi Yuhki; Motoi Okada; Takayasu Kanno; Atsushi Yamauchi; Naohiko Tashiro; Takaaki Sasaki; Shunsuke Okumura; Naoki Nakagawa; Youko Aburakawa; Naofumi Takehara; Takayuki Fujino; Naoyuki Hasebe; Shuh Narumiya; Fumitaka Ushikubi
Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(3):464-70.
2010: Naoki Terada; Yosuke Shimizu; Tomomi Kamba; Takahiro Inoue; Atsushi Maeno; Takashi Kobayashi; Eijiro Nakamura; Toshiyuki Kamoto; Toshiya Kanaji; Takayuki Maruyama; Yoshiki Mikami; Yoshinobu Toda; Toshiyuki Matsuoka; Yasushi Okuno; Gozoh Tsujimoto; Shuh Narumiya; Osamu Ogawa
Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model.
Cancer research 2010;70(4):1606-15.
2010: Hidefumi Kubo; Kanako Hosono; Tatsunori Suzuki; Yasufumi Ogawa; Hiroshi Kato; Hiroki Kamata; Yoshiya Ito; Hideki Amano; Tetsuki Kato; Hiroyuki Sakagami; Izumi Hayashi; Yukihiko Sugimoto; Shuh Narumiya; Masahiko Watanabe; Masataka Majima
Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2010;64(2):101-6.
2010: T Ueno; T Suzuki; A Oikawa; K Hosono; Y Kosaka; Hideki Amano; Hidero Kitasato; M Toda; Izumi Hayashi; T Kato; Yoshiya Ito; Yukihiko Sugimoto; Shuh Narumiya; H Okamoto; Masataka Majima
Recruited bone marrow cells expressing the EP3 prostaglandin E receptor subtype enhance angiogenesis during chronic inflammation.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2010;64(2):93-100.
2010: Muzamil Ahmad; Sofiyan Saleem; Zahoor Shah; Takayuki Maruyama; Shuh Narumiya; Sylvain Dore
The PGE2 EP2 receptor and its selective activation are beneficial against ischemic stroke.
Experimental & translational stroke medicine 2010;2(1):12.
2010: Daiji Sakata; Chengcan Yao; Shuh Narumiya
Prostaglandin E2, an immunoactivator.
Journal of pharmacological sciences 2010;112(1):1-5.
2009: Philip Duffy; Andre Schmandke; Antonio Schmandke; Jonathan Sigworth; Shuh Narumiya; William B J Cafferty; Stephen M Strittmatter
Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(48):15266-76.
2009: Yasuhiro Tanaka; Tomoyuki Furuyashiki; Toshihiko Momiyama; Hisaaki Namba; Akira Mizoguchi; Tomoyuki Mitsumori; Tetsuro Kayahara; Hitoshi Shichi; Kazushi Kimura; Toshiyuki Matsuoka; Hiroyuki Nawa; Shuh Narumiya
Prostaglandin E receptor EP1 enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine level in the dorsal striatum.
The European journal of neuroscience 2009;30(12):2338-46.
2009: Toru Oga; Toshiyuki Matsuoka; Chengcan Yao; Kimiko Nonomura; Shiho Kitaoka; Daiji Sakata; Yoshihiro Kita; Kiminobu Tanizawa; Yoshio Taguchi; Kazuo Chin; Michiaki Mishima; Takao Shimizu; Shuh Narumiya
Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta.
Nature medicine 2009;15(12):1426-30.
2009: Shuh Narumiya; Naoki Watanabe
Migration without a clutch.
Nature cell biology 2009;11(12):1394-6.
2009: Hideki Amano; Yoshiya Ito; Tastunori Suzuki; Shintaro Kato; Yoshio Matsui; Fumihiro Ogawa; Takahiko Murata; Yukihiko Sugimoto; Robert Senior; Hidero Kitasato; Izumi Hayashi; Yukitoshi Satoh; Shuh Narumiya; Masataka Majima
Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis.
Cancer science 2009;100(12):2318-24.
2009: Reiko Hanada; Andreas Leibbrandt; Toshikatsu Hanada; Shiho Kitaoka; Tomoyuki Furuyashiki; Hiroaki Fujihara; Jean Trichereau; Magdalena Paolino; Fatimunnisa Qadri; Ralph Plehm; Steffen Klaere; Vukoslav Komnenovic; Hiromitsu Mimata; Hironobu Yoshimatsu; Naoyuki Takahashi; Arndt von Haeseler; Michael Bader; Sara Sebnem Kilic; Yoichi Ueta; Christian Pifl; Shuh Narumiya; Josef M Penninger
Central control of fever and female body temperature by RANKL/RANK.
Nature 2009;462(7272):505-9.
2009: Shuh Narumiya
Prostanoids and inflammation: a new concept arising from receptor knockout mice.
Journal of molecular medicine (Berlin, Germany) 2009;87(10):1015-22.
2009: Tetsuya Honda; Toshiyuki Matsuoka; Mayumi Ueta; Kenji Kabashima; Yoshiki Miyachi; Shuh Narumiya
Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity.
The Journal of allergy and clinical immunology 2009;124(4):809-18.e2.
2009: Laura Popp; Annett Häussler; Anke Olliges; Rolf Nüsing; Shuh Narumiya; Gerd Geisslinger; Irmgard Tegeder
Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.
European journal of pain (London, England) 2009;13(7):691-703.
2009: Tatsuya Hoshino; Takushi Namba; Masaya Takehara; Tadashi Nakaya; Yukihiko Sugimoto; Wataru Araki; Shuh Narumiya; Toshiharu Suzuki; Tohru Mizushima
Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.
The Journal of biological chemistry 2009;284(27):18493-502.
2009: Rieko Yodoi; Shigero Tamba; K Morimoto; Eri Segi-Nishida; Mika Nishihara; Atsushi Ichikawa; Shuh Narumiya; Yukihiko Sugimoto
RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly.
Endocrinology 2009;150(7):3345-52.
2009: Chengcan Yao; Daiji Sakata; Yoshiyasu Esaki; Youxian Li; Toshiyuki Matsuoka; Kenji Kuroiwa; Yukihiko Sugimoto; Shuh Narumiya
Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion.
Nature medicine 2009;15(6):633-40.
2009: Shuh Narumiya; Masahiro Tanji; Toshimasa Ishizaki
Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion.
Cancer metastasis reviews 2009;28(1-2):65-76.
2009: Yasuhumi Ogawa; Tatsunori Suzuki; Atsuhiko Oikawa; Kanako Hosono; Hidehumi Kubo; Hideki Amano; Yoshiya Ito; Hidero Kitasato; Izumi Hayashi; Tetsuki Kato; Yukihiko Sugimoto; Shuh Narumiya; Masahiko Watanabe; Masataka Majima
Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth.
Biochemical and biophysical research communications 2009;382(4):720-5.
2009: James Monypenny; Daniel Zicha; Chiharu Higashida; Fabian Oceguera-Yanez; Shuh Narumiya; Naoki Watanabe
Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis.
Molecular and cellular biology 2009;29(10):2730-47.
2009: Sofiyan Saleem; Yun Tai Kim; Takayuki Maruyama; Shuh Narumiya; Sylvain Dore
Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia.
Journal of neuroimmunology 2009;208(1-2):87-93.
2009: Takashi Miki; Katsuya Okawa; Toshihiro Sekimoto; Yoshihiro Yoneda; Sadanori Watanabe; Toshimasa Ishizaki; Shuh Narumiya
mDia2 shuttles between the nucleus and the cytoplasm through the importin-{alpha}/{beta}- and CRM1-mediated nuclear transport mechanism.
The Journal of biological chemistry 2009;284(9):5753-62.
2009: Tomoyuki Furuyashiki; Shuh Narumiya
Roles of prostaglandin E receptors in stress responses.
Current opinion in pharmacology 2009;9(1):31-8.
2009: Mayumi Ueta; Toshiyuki Matsuoka; Shuh Narumiya; Shigeru Kinoshita
Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis.
The Journal of allergy and clinical immunology 2009;123(2):466-71.
2009: Sofiyan Saleem; Abdullah Shafique Ahmad; Takayuki Maruyama; Shuh Narumiya; Sylvain Dore
PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia.
Neurotoxicity research 2009;15(1):62-70.
2009: Takahiro Tsuji; Takushi Miyoshi; Chiharu Higashida; Shuh Narumiya; Naoki Watanabe
An order of magnitude faster AIP1-associated actin disruption than nucleation by the Arp2/3 complex in lamellipodia.
PloS one 2009;4(3):e4921.
2008: Guo Wei; K K Kibler; Raymond C Koehler; T Maruyama; Shuh Narumiya; Sylvain Dore
Prostacyclin receptor deletion aggravates hippocampal neuronal loss after bilateral common carotid artery occlusion in mouse.
Neuroscience 2008;156(4):1111-7.
2008: Chiharu Higashida; Shiro Suetsugu; Takahiro Tsuji; James Monypenny; Shuh Narumiya; Naoki Watanabe
G-actin regulates rapid induction of actin nucleation by mDia1 to restore cellular actin polymers.
Journal of cell science 2008;121(Pt 20):3403-12.
2008: Raphael A Nemenoff; Amy M Meyer; Tyler M Hudish; Anthony B Mozer; Amy Snee; Shuh Narumiya; Robert Stearman; Robert A Winn; Mary C M Weiser-Evans; Mark W Geraci; Robert L Keith
Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of peroxisomal proliferator--activated receptor gamma.
Cancer prevention research (Philadelphia, Pa.) 2008;1(5):349-56.
2008: Hiroyuki Katagiri; Yoshiya Ito; Sohei Ito; Takahiko Murata; Sugimoto Yukihiko; Shuh Narumiya; Masahiko Watanabe; Masataka Majima
TNF-alpha induces thromboxane receptor signaling-dependent microcirculatory dysfunction in mouse liver.
Shock (Augusta, Ga.) 2008;30(4):463-7.
2008: Shigero Tamba; Rieko Yodoi; Eri Segi-Nishida; Atsushi Ichikawa; Shuh Narumiya; Yukihiko Sugimoto
Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14539-44.
2008: Toshiyuki Matsuoka; Shuh Narumiya
The roles of prostanoids in infection and sickness behaviors.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2008;14(4):270-8.
2008: Sadanori Watanabe; Yoshikazu Ando; Shingo Yasuda; Hiroshi Hosoya; Naoki Watanabe; Toshimasa Ishizaki; Shuh Narumiya
mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells.
Molecular biology of the cell 2008;19(5):2328-38.
2008: Koh-ichi Yuhki; Fumitaka Ushikubi; Hiroaki Naraba; Akinori Ueno; Hirotsugu Kato; Fumiaki Kojima; Shuh Narumiya; Yukihiko Sugimoto; Misao Matsushita; Sachiko Oh-Ishi
Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy.
The Journal of pharmacology and experimental therapeutics 2008;325(2):601-9.
2008: Xiaojun Wang; Yoshiharu Momota; Haruko Yanase; Shuh Narumiya; Takayuki Maruyama; Masahito Kawatani
Urothelium EP1 receptor facilitates the micturition reflex in mice.
Biomedical research (Tokyo, Japan) 2008;29(2):105-11.
2008: Ryu Takeya; Kenichiro Taniguchi; Shuh Narumiya; Hideki Sumimoto
The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells.
The EMBO journal 2008;27(4):618-28.
2008: Mitsumasa Koyanagi; Jun Takahashi; Yoshiki Arakawa; Daisuke Doi; Hitoshi Fukuda; Hideki Hayashi; Shuh Narumiya; Nobuo Hashimoto
Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors.
Journal of neuroscience research 2008;86(2):270-80.
2008: David Torres; Christophe Paget; Josette Fontaine; Thierry Mallevaey; Toshiyuki Matsuoka; Takayuki Maruyama; Shuh Narumiya; Monique Capron; Philippe Gosset; Christelle Faveeuw; François Trottein
Prostaglandin D2 inhibits the production of IFN-gamma by invariant NK T cells: consequences in the control of B16 melanoma.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):783-92.
2007: Miyako Nagamachi; Daiji Sakata; Kenji Kabashima; Tomoyuki Furuyashiki; Takahiko Murata; Eri Segi-Nishida; Kitipong Soontrapa; Toshiyuki Matsuoka; Yoshiki Miyachi; Shuh Narumiya
Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1.
The Journal of experimental medicine 2007;204(12):2865-74.
2007: Shiho Kitaoka; Tomoyuki Furuyashiki; Akinori Nishi; Takahide Shuto; Sho Koyasu; Toshiyuki Matsuoka; Masayuki Miyasaka; Paul Greengard; Shuh Narumiya
Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(47):12900-7.
2007: Tatsuya Hoshino; Tadashi Nakaya; Takashi Homan; Ken-ichiro Tanaka; Yukihiko Sugimoto; Wataru Araki; Masami Narita; Shuh Narumiya; Toshiharu Suzuki; Tohru Mizushima
Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo.
The Journal of biological chemistry 2007;282(45):32676-88.
2007: Michio Noguchi; Kiminori Hosoda; Junji Fujikura; Muneya Fujimoto; Hiroshi Iwakura; Tsutomu Tomita; Takako Ishii; Naoki Arai; Masakazu Hirata; Ken Ebihara; Hiroaki Masuzaki; Hiroshi Itoh; Shuh Narumiya; Kazuwa Nakao
Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis.
The Journal of biological chemistry 2007;282(40):29574-83.
2007: Yoshikazu Ando; Shingo Yasuda; Fabian Oceguera-Yanez; Shuh Narumiya
Inactivation of Rho GTPases with Clostridium difficile toxin B impairs centrosomal activation of Aurora-A in G2/M transition of HeLa cells.
Molecular biology of the cell 2007;18(10):3752-63.
2007: Daiji Sakata; Hiroyuki Taniguchi; Shingo Yasuda; Aki Adachi-Morishima; Yoko Hamazaki; Rika Nakayama; Takashi Miki; Nagahiro Minato; Shuh Narumiya
Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1.
The Journal of experimental medicine 2007;204(9):2031-8.
2007: Suchitra Devi Gopinath; Shuh Narumiya; Jyotsna Dhawan
The RhoA effector mDiaphanous regulates MyoD expression and cell cycle progression via SRF-dependent and SRF-independent pathways.
Journal of cell science 2007;120(Pt 17):3086-98.
2007: Ana-Marija Hristovska; Lasse E Rasmussen; Pernille B Hansen; Susan S Nielsen; Rolf M Nüsing; Shuh Narumiya; Paul Vanhoutte; Ole Skøtt; Boye L Jensen
Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthase.
Hypertension 2007;50(3):525-30.
2007: Michele Pelosi; Francesco Marampon; Bianca M Zani; Sabrina Prudente; Emerald Perlas; Viviana Caputo; Luciano Cianetti; Valeria Berno; Shuh Narumiya; Shin W Kang; Antonio Musarò; Nadia Rosenthal
ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program.
Molecular and cellular biology 2007;27(17):6163-76.
2007: Tsugunobu Andoh; Yumi Nishikawa; Tomomi Yamaguchi-Miyamoto; Hiroshi Nojima; Shuh Narumiya; Yasushi Kuraishi
Thromboxane A2 induces itch-associated responses through TP receptors in the skin in mice.
The Journal of investigative dermatology 2007;127(8):2042-7.
2007: Sofiyan Saleem; Hean Zhuang; Artur J de Brum-Fernandes; Takayuki Maruyama; Shuh Narumiya; Sylvain Dore
PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury.
The European journal of neuroscience 2007;26(1):73-8.
2007: Takashi Ota; Makoto Aihara; Tadashiro Saeki; Shuh Narumiya; Makoto Araie
The IOP-lowering effects and mechanism of action of tafluprost in prostanoid receptor-deficient mice.
The British journal of ophthalmology 2007;91(5):673-6.
2007: Yukihiko Sugimoto; Shuh Narumiya
Prostaglandin E receptors.
The Journal of biological chemistry 2007;282(16):11613-7.
2007: Hidetoshi Taniguchi; Ikuko Mohri; Hitomi Okabe-Arahori; Kosuke Aritake; Kazuko Wada; Takahisa Kanekiyo; Shuh Narumiya; Masahiro Nakayama; Keiichi Ozono; Yoshihiro Urade; Masako Taniike
Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(16):4303-12.
2007: Muzamil Ahmad; Abdullah Shafique Ahmad; Hean Zhuang; Takayuki Maruyama; Shuh Narumiya; Sylvain Dore
Stimulation of prostaglandin E2-EP3 receptors exacerbates stroke and excitotoxic injury.
Journal of neuroimmunology 2007;184(1-2):172-9.
2007: Hamida Hammad; Mirjam Kool; Thomas Soullié; Shuh Narumiya; François Trottein; Henk C Hoogsteden; Bart N Lambrecht
Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells.
The Journal of experimental medicine 2007;204(2):357-67.
2007: Toshiyuki Matsuoka; Shuh Narumiya
Prostaglandin receptor signaling in disease.
TheScientificWorldJournal 2007;7():1329-47.
2007: Kenji Kabashima; Miyako Nagamachi; Tetsuya Honda; Chikako Nishigori; Yoshiki Miyachi; Yoshiki Tokura; Shuh Narumiya
Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors.
Laboratory investigation; a journal of technical methods and pathology 2007;87(1):49-55.
2006: Xin Zhuge; Hidenori Arai; Yang Xu; Toshinori Murayama; Takuya Kobayashi; Shuh Narumiya; Toru Kita; Masayuki Yokode
Protection of atherogenesis in thromboxane A2 receptor-deficient mice is not associated with thromboxane A2 receptor in bone marrow-derived cells.
Biochemical and biophysical research communications 2006;351(4):865-71.
2006: Takushi Miyoshi; Takahiro Tsuji; Chiharu Higashida; Maud Hertzog; Akiko Fujita; Shuh Narumiya; Giorgio Scita; Naoki Watanabe
Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing.
The Journal of cell biology 2006;175(6):947-55.
2006: Katharina Hösl; Heiko Reinold; Robert Justin Harvey; Ulrike Müller; Shuh Narumiya; Hanns Ulrich Zeilhofer
Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor alpha3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain after peripheral nerve injury or formalin injection.
Pain 2006;126(1-3):46-53.
2006: Wei-Min Qu; Zhi-Li Huang; Xin-Hong Xu; Kosuke Aritake; Naomi Eguchi; Fumio Nambu; Shuh Narumiya; Yoshihiro Urade; Osamu Hayaishi
Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17949-54.
2006: Li Yang; Yuhui Huang; Rut Porta; Kiyoshi Yanagisawa; Adriana Gonzalez; Eri Segi; David H Johnson; Shuh Narumiya; Yuhui Huang
Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism.
Cancer research 2006;66(19):9665-72.
2006: Emi Kamoshita; Yasuhiro Ikeda; Mamoru Fujita; Hideki Amano; Atsuhiko Oikawa; Tastunori Suzuki; Yasuhumi Ogawa; Shohei Yamashina; Sadahiro Azuma; Shuh Narumiya; Nobuya Unno; Masataka Majima
Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound-induced angiogenesis.
The American journal of pathology 2006;169(4):1458-72.
2006: Norikazu Yamana; Yoshiki Arakawa; Tomohiro Nishino; Kazuo Kurokawa; Masahiro Tanji; Reina E Itoh; James Monypenny; Toshimasa Ishizaki; Haruhiko Bito; Kazuhiko Nozaki; Nobuo Hashimoto; Michiyuki Matsuda; Shuh Narumiya
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src.
Molecular and cellular biology 2006;26(18):6844-58.
2006: Takashi Ota; Makoto Aihara; Tadashiro Saeki; Shuh Narumiya; Makoto Araie
The effects of prostaglandin analogues on prostanoid EP1, EP2, and EP3 receptor-deficient mice.
Investigative ophthalmology & visual science 2006;47(8):3395-9.
2006: Shogo Ohmae; Sayaka Takemoto-Kimura; Michiko Okamura; Aki Adachi-Morishima; Mio Nonaka; Toshimitsu Fuse; Satoshi Kida; Masahiro Tanji; Tomoyuki Furuyashiki; Yoshiki Arakawa; Shuh Narumiya; Hiroyuki Okuno; Haruhiko Bito
Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV.
The Journal of biological chemistry 2006;281(29):20427-39.
2006: Shingo Yasuda; Hiroyuki Taniguchi; Fabian Oceguera-Yanez; Yoshikazu Ando; Sadanori Watanabe; James Monypenny; Shuh Narumiya
An essential role of Cdc42-like GTPases in mitosis of HeLa cells.
FEBS letters 2006;580(14):3375-80.
2006: Ikuko Mohri; Masako Taniike; Hidetoshi Taniguchi; Takahisa Kanekiyo; Kosuke Aritake; Takashi Inui; Noriko Fukumoto; Naomi Eguchi; Atsuko Kushi; Hitoshi Sasai; Yoshihide Kanaoka; Keiichi Ozono; Shuh Narumiya; Kinuko Suzuki; Yoshihiro Urade
Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(16):4383-93.
2006: Shuh Narumiya; Shingo Yasuda
Rho GTPases in animal cell mitosis.
Current opinion in cell biology 2006;18(2):199-205.
2006: Tetsuya Honda; Eri Segi-Nishida; Yoshiki Miyachi; Shuh Narumiya
Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis.
The Journal of experimental medicine 2006;203(2):325-35.
2006: Shingo Yasuda; Shuh Narumiya
Analysis of a mitotic role of Cdc42.
Methods in enzymology 2006;406():656-65.
2006: Fabian Oceguera-Yanez; Shuh Narumiya
Measurement of activity of rho GTPases during mitosis.
Methods in enzymology 2006;406():332-45.
2005: Yutaka Shoji; Mami Takahashi; Nobuo Takasuka; Naoko Niho; Tomohiro Kitamura; Hidetaka Sato; Takayuki Maruyama; Yukihiko Sugimoto; Shuh Narumiya; Takashi Sugimura; Keiji Wakabayashi
Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis.
Carcinogenesis 2005;26(12):2116-22.
2005: Kazuo Emoto; Hironori Inadome; Yasunori Kanaho; Shuh Narumiya; Masato Umeda
Local change in phospholipid composition at the cleavage furrow is essential for completion of cytokinesis.
The Journal of biological chemistry 2005;280(45):37901-7.
2005: Takashi Ota; Makoto Aihara; Shuh Narumiya; Makoto Araie
The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice.
Investigative ophthalmology & visual science 2005;46(11):4159-63.
2005: Yoko Matsuoka; Tomoyuki Furuyashiki; Kiyofumi Yamada; Taku Nagai; Haruhiko Bito; Yasuhiro Tanaka; Shiho Kitaoka; Fumitaka Ushikubi; Toshitaka Nabeshima; Shuh Narumiya
Prostaglandin E receptor EP1 controls impulsive behavior under stress.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):16066-71.
2005: Hidenori Ito; Ikuko Iwamoto; Rika Morishita; Yoshinori Nozawa; Shuh Narumiya; Tomiko Asano; Koh-Ichi Nagata
Possible role of Rho/Rhotekin signaling in mammalian septin organization.
Oncogene 2005;24(47):7064-72.
2005: Ichiro Takasaki; Hiroshi Nojima; Kimiyasu Shiraki; Yukihiko Sugimoto; Atsushi Ichikawa; Fumitaka Ushikubi; Shuh Narumiya; Yasushi Kuraishi
Involvement of cyclooxygenase-2 and EP3 prostaglandin receptor in acute herpetic but not postherpetic pain in mice.
Neuropharmacology 2005;49(3):283-92.
2005: Dean Thumkeo; Yoshihiko Shimizu; Satoko Sakamoto; Shuichi Yamada; Shuh Narumiya
ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(8):825-34.
2005: Rolf M Nüsing; Antje Treude; Christian Weissenberger; Boye Jensen; Martin Bek; Charlotte Wagner; Shuh Narumiya; Hannsjörg W Seyberth
Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome.
Journal of the American Society of Nephrology : JASN 2005;16(8):2354-62.
2005: Akiyoshi Hara; Koh-ichi Yuhki; Takayuki Fujino; Takehiro Yamada; Koji Takayama; Shuhko Kuriyama; Osamu Takahata; Hideji Karibe; Yuji Okada; Chun-Yang Xiao; Hong Ma; Shuh Narumiya; Fumitaka Ushikubi
Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor.
Circulation 2005;112(1):84-92.
2005: Koji Takayama; Koh-ichi Yuhki; Kyoichi Ono; Takayuki Fujino; Akiyoshi Hara; Takehiro Yamada; Shuhko Kuriyama; Hideji Karibe; Yuji Okada; Osamu Takahata; Takanobu Taniguchi; Toshihiko Iijima; Hiroshi Iwasaki; Shuh Narumiya; Fumitaka Ushikubi
Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia.
Nature medicine 2005;11(5):562-6.
2005: Tomonori Kunikata; Hana Yamane; Eri Segi; Toshiyuki Matsuoka; Yukihiko Sugimoto; Satoshi Tanaka; Hiroyuki Tanaka; Hiroichi Nagai; Atsushi Ichikawa; Shuh Narumiya
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3.
Nature immunology 2005;6(5):524-31.
2005: Lorena Riol-Blanco; Noelia Sánchez-Sánchez; Ana Torres; Alberto Tejedor; Shuh Narumiya; Angel L Corbí; Paloma Sánchez-Mateos; José Luis Rodríguez-Fernández
The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4070-80.
2005: Yoshihiko Shimizu; Dean Thumkeo; Jeongsin Keel; Toshimasa Ishizaki; Hiroko Oshima; Masanobu Oshima; Yoichi Noda; Fumio Matsumura; Makoto M Taketo; Shuh Narumiya
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles.
The Journal of cell biology 2005;168(6):941-53.
2005: Heiko Reinold; Seifollah Ahmadi; Ulrike B Depner; Beate Layh; Cornelia Heindl; May Hamza; Andreas Pahl; Kay Brune; Shuh Narumiya; Ulrike Müller; Hanns Ulrich Zeilhofer
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype.
The Journal of clinical investigation 2005;115(3):673-9.
2005: Toshihiko Kawamori; Tomohiro Kitamura; Kouji Watanabe; Naoaki Uchiya; Takayuki Maruyama; Shuh Narumiya; Takashi Sugimura; Keiji Wakabayashi
Prostaglandin E receptor subtype EP(1) deficiency inhibits colon cancer development.
Carcinogenesis 2005;26(2):353-7.
2005: Fabian Oceguera-Yanez; Kazuhiro Kimura; Shingo Yasuda; Chiharu Higashida; Toshio Kitamura; Yasushi Hiraoka; Tokuko Haraguchi; Shuh Narumiya
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
The Journal of cell biology 2005;168(2):221-32.
2005: Tomoko Moriyama; Tomohiro Higashi; Kazuya Togashi; Tohko Iida; Eri Segi; Yukihiko Sugimoto; Tomoko Tominaga; Shuh Narumiya; Makoto Tominaga
Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins.
Molecular pain 2005;1():3.
2005: Hidetsuna Watanabe; Tetsuo Katoh; Masaaki Eiro; Masaya Iwamoto; Fumitaka Ushikubi; Shuh Narumiya; Tsuyoshi Watanabe
Effects of salt loading on blood pressure in mice lacking the prostanoid receptor gene.
Circulation journal : official journal of the Japanese Circulation Society 2005;69(1):124-6.
2004: Koh-ichi Yuhki; Akinori Ueno; Hiroaki Naraba; Fumiaki Kojima; Fumitaka Ushikubi; Shuh Narumiya; Sachiko Oh-Ishi
Prostaglandin receptors EP2, EP3, and IP mediate exudate formation in carrageenin-induced mouse pleurisy.
The Journal of pharmacology and experimental therapeutics 2004;311(3):1218-24.
2004: Takayuki Fujino; Naoki Nakagawa; Koh-ichi Yuhki; Akiyoshi Hara; Takehiro Yamada; Koji Takayama; Shuhko Kuriyama; Yayoi Hosoki; Osamu Takahata; Takanobu Taniguchi; Jun Fukuzawa; Naoyuki Hasebe; Kenjiro Kikuchi; Shuh Narumiya; Fumitaka Ushikubi
Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP.
The Journal of clinical investigation 2004;114(6):805-12.
2004: Takuya Kobayashi; Yoshio Tahara; Mayumi Matsumoto; Masako Iguchi; Hideto Sano; Toshinori Murayama; Hidenori Arai; Hiroji Oida; Takami Yurugi-Kobayashi; Jun K Yamashita; Hiroyuki Katagiri; Masataka Majima; Masayuki Yokode; Toru Kita; Shuh Narumiya
Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice.
The Journal of clinical investigation 2004;114(6):784-94.
2004: Frank Schweda; Jürgen Klar; Shuh Narumiya; Rolf M Nüsing; Armin Kurtz
Stimulation of renin release by prostaglandin E2 is mediated by EP2 and EP4 receptors in mouse kidneys.
American journal of physiology. Renal physiology 2004;287(3):F427-33.
2004: Yutaka Shoji; Mami Takahashi; Tomohiro Kitamura; Kouji Watanabe; Toshihiko Kawamori; Takayuki Maruyama; Y Sugimoto; M Negishi; Shuh Narumiya; Takashi Sugimura; Keiji Wakabayashi
Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development.
Gut 2004;53(8):1151-8.
2004: Hiroshi Ueda; Rika Morishita; Shuh Narumiya; Kanefusa Kato; Tomiko Asano
Galphaq/11 signaling induces apoptosis through two pathways involving reduction of Akt phosphorylation and activation of RhoA in HeLa cells.
Experimental cell research 2004;298(1):207-17.
2004: Shuh Narumiya; Fabian Oceguera-Yanez; Shingo Yasuda
A new look at Rho GTPases in cell cycle: role in kinetochore-microtubule attachment.
Cell cycle (Georgetown, Tex.) 2004;3(7):855-7.
2004: Chun-Yang Xiao; Koh-ichi Yuhki; Akiyoshi Hara; Takayuki Fujino; Shuhko Kuriyama; Takehiro Yamada; Koji Takayama; Osamu Takahata; Hideji Karibe; Takanobu Taniguchi; Shuh Narumiya; Fumitaka Ushikubi
Prostaglandin E2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP4.
Circulation 2004;109(20):2462-8.
2004: Shingo Yasuda; Fabian Oceguera-Yanez; Takayuki Kato; Muneo Okamoto; Shigenobu Yonemura; Yasuhiko Terada; Toshimasa Ishizaki; Shuh Narumiya
Cdc42 and mDia3 regulate microtubule attachment to kinetochores.
Nature 2004;428(6984):767-71.
2004: Maria Julia Marinissen; Mario Chiariello; Tamara Tanos; Ora Bernard; Shuh Narumiya; J Silvio Gutkind
The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis.
Molecular cell 2004;14(1):29-41.
2004: Chiharu Higashida; Takushi Miyoshi; Akiko Fujita; Fabian Oceguera-Yanez; James Monypenny; Yoshikazu Andou; Shuh Narumiya; Naoki Watanabe
Actin polymerization-driven molecular movement of mDia1 in living cells.
Science (New York, N.Y.) 2004;303(5666):2007-10.
2004: Atsushi Shimada; Miklós Nyitrai; Ingrid R Vetter; Dorothee Kühlmann; Beáta Bugyi; Shuh Narumiya; Michael A Geeves; Alfred Wittinghofer
The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization.
Molecular cell 2004;13(4):511-22.
2004: Hiroyuki Katagiri; Yoshiya Ito; Ken-ichiro Ishii; Izumi Hayashi; Makoto Suematsu; Shohei Yamashina; Takahiko Murata; Shuh Narumiya; Akira Kakita; Masataka Majima
Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice.
Hepatology (Baltimore, Md.) 2004;39(1):139-50.
2004: Cinzia Giagulli; Elio Scarpini; Linda Ottoboni; Shuh Narumiya; Eugene C Butcher; Gabriela Constantin; Carlo Laudanna
RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing.
Immunity 2004;20(1):25-35.
2003: Shuh Narumiya
Prostanoids in immunity: roles revealed by mice deficient in their receptors.
Life sciences 2003;74(2-3):391-5.
2003: Takayoshi Suganami; Kiyoshi Mori; Issei Tanaka; Masashi Mukoyama; Akira Sugawara; Hisashi Makino; Shigeo Muro; Kensei Yahata; Shuichi Ohuchida; Takayuki Maruyama; Shuh Narumiya; Kazuwa Nakao
Role of prostaglandin E receptor EP1 subtype in the development of renal injury in genetically hypertensive rats.
Hypertension 2003;42(6):1183-90.
2003: Takehiro Yamada; Takayuki Fujino; Koh-ichi Yuhki; Akiyoshi Hara; Hideji Karibe; Osamu Takahata; Yuji Okada; Chun-Yang Xiao; Koji Takayama; Shuhko Kuriyama; Takanobu Taniguchi; Takahiro Shiokoshi; Yoshinobu Ohsaki; Kenjiro Kikuchi; Shuh Narumiya; Fumitaka Ushikubi
Thromboxane A2 regulates vascular tone via its inhibitory effect on the expression of inducible nitric oxide synthase.
Circulation 2003;108(19):2381-6.
2003: Akiyoshi Hara; Koh-ichi Yuhki; Takayuki Fujino; Shuh Narumiya; Fumitaka Ushikubi
[Pathophysiological roles of the prostanoids in the cardiovascular system: studies using mice deficient in prostanoid receptors].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(5):384-90.
2003: Maxime Hervé; Véronique Angeli; Elena Pinzar; René Wintjens; Christelle Faveeuw; Shuh Narumiya; André Capron; Yoshihiro Urade; Monique Capron; Gilles Riveau; François Trottein
Pivotal roles of the parasite PGD2 synthase and of the host D prostanoid receptor 1 in schistosome immune evasion.
European journal of immunology 2003;33(10):2764-72.
2003: Takakazu Oka; Kae Oka; Takuya Kobayashi; Yukihiko Sugimoto; Atsushi Ichikawa; Fumitaka Ushikubi; Shuh Narumiya; Clifford B Saper
Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors.
The Journal of physiology 2003;551(Pt 3):945-54.
2003: Shuh Narumiya
Signal transduction underlying cell morphogenesis: editorial overview.
Journal of biochemistry 2003;134(3):305-7.
2003: Katsuharu Arai; Takashi Ohno; Takeo Saeki; Sumito Mizuguchi; Kazuhisa Kamata; Izumi Hayashi; Katsunori Saigenji; T Murata; Shuh Narumiya; Masataka Majima
Endogenous prostaglandin I2 regulates the neural emergency system through release of calcitonin gene related peptide.
Gut 2003;52(9):1242-9.
2003: Koichi Nagao; Hiroyuki Tanaka; Masato Komai; Taisei Masuda; Shuh Narumiya; Hiroichi Nagai
Role of prostaglandin I2 in airway remodeling induced by repeated allergen challenge in mice.
American journal of respiratory cell and molecular biology 2003;29(3 Pt 1):314-20.
2003: Kenji Kabashima; Shuh Narumiya
The DP receptor, allergic inflammation and asthma.
Prostaglandins, leukotrienes, and essential fatty acids 2003;69(2-3):187-94.
2003: Asako Otomo; Shinji Hadano; Takeya Okada; Hikaru Mizumura; Ryota Kunita; Hitoshi Nishijima; Junko Showguchi-Miyata; Yoshiko Yanagisawa; Eri Kohiki; Etsuko Suga; Masanori Yasuda; Hitoshi Osuga; Takeharu Nishimoto; Shuh Narumiya; Joh-E Ikeda
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics.
Human molecular genetics 2003;12(14):1671-87.
2003: Dean Thumkeo; Jeongsin Keel; Toshimasa Ishizaki; Masaya Hirose; Kimiko Nonomura; Hiroko Oshima; Masanobu Oshima; Makoto M Taketo; Shuh Narumiya
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death.
Molecular and cellular biology 2003;23(14):5043-55.
2003: Toshiaki Minami; Shinji Matsumura; Tamaki Mabuchi; Takuya Kobayashi; Yukihiko Sugimoto; Fumitaka Ushikubi; Atsushi Ichikawa; Shuh Narumiya; Seiji Ito
Functional evidence for interaction between prostaglandin EP3 and kappa-opioid receptor pathways in tactile pain induced by human immunodeficiency virus type-1 (HIV-1) glycoprotein gp120.
Neuropharmacology 2003;45(1):96-105.
2003: Kenji Kabashima; Takahiko Murata; Hiroyuki Tanaka; Toshiyuki Matsuoka; Daiji Sakata; Nobuaki Yoshida; Koko Katagiri; Tatsuo Kinashi; Toshiyuki Tanaka; Masayuki Miyasaka; Hiroichi Nagai; Fumitaka Ushikubi; Shuh Narumiya
Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity.
Nature immunology 2003;4(7):694-701.
2003: Kenji Kabashima; Daiji Sakata; Miyako Nagamachi; Yoshiki Miyachi; Kayo Inaba; Shuh Narumiya
Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells.
Nature medicine 2003;9(6):744-9.
2003: Osamu Saito; Youfei Guan; Zhonghua Qi; Linda S Davis; Martin Kömhoff; Yukihiko Sugimoto; Shuh Narumiya; Richard M Breyer; Matthew D Breyer
Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract.
American journal of physiology. Renal physiology 2003;284(6):F1164-70.
2003: Sayaka Takemoto-Kimura; Hisashi Terai; Maki Takamoto; Shogo Ohmae; Shoko Kikumura; Eri Segi; Yoshiki Arakawa; Tomoyuki Furuyashiki; Shuh Narumiya; Haruhiko Bito
Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).
The Journal of biological chemistry 2003;278(20):18597-605.
2003: Shigeko Yamashiro; Go Totsukawa; Yoshihiko Yamakita; Yasuharu Sasaki; Pascal Madaule; Toshimaa Ishizaki; Shuh Narumiya; Fumio Matsumura
Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II.
Molecular biology of the cell 2003;14(5):1745-56.
2003: Yoshiki Arakawa; Haruhiko Bito; Tomoyuki Furuyashiki; Takahiro Tsuji; Sayaka Takemoto-Kimura; Kazuhiro Kimura; Kazuhiko Nozaki; Nobuo Hashimoto; Shuh Narumiya
Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons.
The Journal of cell biology 2003;161(2):381-91.
2003: Yukinori Minoshima; Toshiyuki Kawashima; Koichi Hirose; Yukio Tonozuka; Aie Kawajiri; Ying Chun Bao; Xingming Deng; Masaaki Tatsuka; Shuh Narumiya; W Stratford May; Tetsuya Nosaka; Kentaro Semba; takafumi inoue; Takaya Satoh; Masaki Inagaki; Toshio Kitamura
Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis.
Developmental cell 2003;4(4):549-60.
2003: Christelle Faveeuw; Philippe Gosset; Fabrice Bureau; Véronique Angeli; Hiroyuki Hirai; Takayuki Maruyama; Shuh Narumiya; Monique Capron; François Trottein
Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways.
European journal of immunology 2003;33(4):889-98.
2003: Yoko Matsuoka; Tomoyuki Furuyashiki; Haruhiko Bito; Fumitaka Ushikubi; Yasuhiro Tanaka; Takuya Kobayashi; Shigeo Muro; Noriko Satoh; Tetsuro Kayahara; Mikito Higashi; Akira Mizoguchi; Hitoshi Shichi; Yoshihiro Fukuda; Kazuwa Nakao; Shuh Narumiya
Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4132-7.
2003: Florence Massiera; Perla Saint-Marc; Josiane Seydoux; Takahiko Murata; Takuya Kobayashi; Shuh Narumiya; Philippe Guesnet; Ez-Zoubir Amri; Raymond Negrel; Gérard Ailhaud
Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern?
Journal of lipid research 2003;44(2):271-9.
2003: Hideki Amano; Izumi Hayashi; Hirahito Endo; Hidero Kitasato; Shohei Yamashina; Takayuki Maruyama; Michiyoshi Kobayashi; Kazutoyo Satoh; Masami Narita; Yukihiko Sugimoto; Takahiko Murata; Hirokuni Yoshimura; Shuh Narumiya; Masataka Majima
Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth.
The Journal of experimental medicine 2003;197(2):221-32.
2002: Tomoyuki Furuyashiki; Yoshiki Arakawa; Sayaka Takemoto-Kimura; Haruhiko Bito; Shuh Narumiya
Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14458-63.
2002: Yoshimasa Takahashi; Shota Tokuoka; Taisei Masuda; Yousuke Hirano; Masafumi Nagao; Hiroyuki Tanaka; Naoki Inagaki; Shuh Narumiya; Hiroichi Nagai
Augmentation of allergic inflammation in prostanoid IP receptor deficient mice.
British journal of pharmacology 2002;137(3):315-22.
2002: Shuh Narumiya; Issei Mabuchi
Cell biology: spinning actin to divide.
Nature 2002;419(6902):27-8.
2002: Takuya Kobayashi; Shuh Narumiya
Function of prostanoid receptors: studies on knockout mice.
Prostaglandins & other lipid mediators 2002;68-69():557-73.
2002: Hisashi Makino; Issei Tanaka; Masashi Mukoyama; Akira Sugawara; Kiyoshi Mori; Shigeo Muro; Takayoshi Suganami; Kensei Yahata; Rieko Ishibashi; Shuichi Ohuchida; Takayuki Maruyama; Shuh Narumiya; Kazuwa Nakao
Prevention of diabetic nephropathy in rats by prostaglandin E receptor EP1-selective antagonist.
Journal of the American Society of Nephrology : JASN 2002;13(7):1757-65.
2002: Takayuki Fujino; Koh-ichi Yuhki; Takehiro Yamada; Akiyoshi Hara; Osamu Takahata; Yuji Okada; Chun-Yang Xiao; Hong Ma; Hideji Karibe; Yasunori Iwashima; Jun Fukuzawa; Naoyuki Hasebe; Kenjiro Kikuchi; Shuh Narumiya; Fumitaka Ushikubi
Effects of the prostanoids on the proliferation or hypertrophy of cultured murine aortic smooth muscle cells.
British journal of pharmacology 2002;136(4):530-9.
2002: Véronique Chevrier; Matthieu Piel; Nora Collomb; Yasmina Saoudi; Ronald Frank; Michel Paintrand; Shuh Narumiya; Michel Bornens; Didier Job
The Rho-associated protein kinase p160ROCK is required for centrosome positioning.
The Journal of cell biology 2002;157(5):807-17.
2002: Takahiro Tsuji; Toshimasa Ishizaki; Muneo Okamoto; Chiharu Higashida; Kazuhiro Kimura; Tomoyuki Furuyashiki; Yoshiki Arakawa; Raymond B Birge; Tetsuya Nakamoto; Hisamaru Hirai; Shuh Narumiya
ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts.
The Journal of cell biology 2002;157(5):819-30.
2002: Keiji Yoshida; Hiroji Oida; Takuya Kobayashi; Takayuki Maruyama; Masaharu Tanaka; Teruaki Katayama; Kojiro Yamaguchi; Eri Segi; Tadao Tsuboyama; Mutsumi Matsushita; Kosei Ito; Yoshiaki Ito; Yukihiko Sugimoto; Fumitaka Ushikubi; Shuichi Ohuchida; Kigen Kondo; Takashi Nakamura; Shuh Narumiya
Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4580-5.
2002: Fumitaka Ushikubi; Shuh Narumiya
[The roles of the prostanoids played in the body].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2002;119(4):201-7.
2002: Kenji Kabashima; Tomomi Saji; Takahiko Murata; Miyako Nagamachi; Toshiyuki Matsuoka; Eri Segi; Kazuhito Tsuboi; Yukihiko Sugimoto; Takuya Kobayashi; Yoshiki Miyachi; Atsushi Ichikawa; Shuh Narumiya
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.
The Journal of clinical investigation 2002;109(7):883-93.
2002: Hiroshi Seno; Masanobu Oshima; Tomo-o Ishikawa; Hiroko Oshima; Kazuaki Takaku; Tsutomu Chiba; Shuh Narumiya; Makoto M Taketo
Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps.
Cancer research 2002;62(2):506-11.
2002: Takuya Kobayashi; Shuh Narumiya
Prostanoids in health and disease; lessons from receptor-knockout mice.
Advances in experimental medicine and biology 2002;507():593-7.
2002: Michihiro Mutoh; Kouji Watanabe; Tomohiro Kitamura; Yutaka Shoji; Mami Takahashi; Toshihiko Kawamori; Kousuke Tani; Michiyoshi Kobayashi; Takayuki Maruyama; Kaoru Kobayashi; Shuichi Ohuchida; Yukihiko Sugimoto; Shuh Narumiya; Takashi Sugimura; Keiji Wakabayashi
Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.
Cancer research 2002;62(1):28-32.
2001: José Luis Rodríguez-Fernández; Lorena Sánchez-Martín; M Rey; Miguel Vicente-Manzanares; Shuh Narumiya; Joaquin Teixidó; Francisco Sánchez-Madrid; Carlos Cabañas
Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1.
The Journal of biological chemistry 2001;276(44):40518-27.
2001: Nathalie Belmonte; Blaine W Phillips; Florence Massiera; Phi Villageois; Brigitte Wdziekonski; Perla Saint-Marc; J Nichols; J Aubert; K Saeki; A Yuo; Shuh Narumiya; Gérard Ailhaud; Christian Dani
Activation of extracellular signal-regulated kinases and CREB/ATF-1 mediate the expression of CCAAT/enhancer binding proteins beta and -delta in preadipocytes.
Molecular endocrinology (Baltimore, Md.) 2001;15(11):2037-49.
2001: Chun-Yang Xiao; Akiyoshi Hara; Koh-ichi Yuhki; Takayuki Fujino; Hong Ma; Yuji Okada; Osamu Takahata; Takehiro Yamada; T Murata; Shuh Narumiya; Fumitaka Ushikubi
Roles of prostaglandin I(2) and thromboxane A(2) in cardiac ischemia-reperfusion injury: a study using mice lacking their respective receptors.
Circulation 2001;104(18):2210-5.
2001: Akira Mizoguchi; Naomi Eguchi; K Kimura; Y Kiyohara; Wei-Min Qu; Zhi-Li Huang; Takatoshi Mochizuki; Michael Lazarus; Takuya Kobayashi; Takeshi Kaneko; Shuh Narumiya; Yoshihiro Urade; Osamu Hayaishi
Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11674-9.
2001: Hong Ma; Akiyoshi Hara; Chun-Yang Xiao; Yuji Okada; Osamu Takahata; K Nakaya; Y Sugimoto; A Ichikawa; Shuh Narumiya; Fumitaka Ushikubi
Increased bleeding tendency and decreased susceptibility to thromboembolism in mice lacking the prostaglandin E receptor subtype EP(3).
Circulation 2001;104(10):1176-80.
2001: M Eda; Shigenobu Yonemura; Takayuki Kato; Naoki Watanabe; Toshimasa Ishizaki; P Madaule; Shuh Narumiya
Rho-dependent transfer of Citron-kinase to the cleavage furrow of dividing cells.
Journal of cell science 2001;114(Pt 18):3273-84.
2001: Masahiro Sonoshita; Kazuaki Takaku; N Sasaki; Y Sugimoto; F Ushikubi; Shuh Narumiya; Masanobu Oshima; Makoto M Taketo
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice.
Nature medicine 2001;7(9):1048-51.
2001: Akinori Ueno; H Matsumoto; Hiroaki Naraba; Y Ikeda; Fumitaka Ushikubi; T Matsuoka; Shuh Narumiya; Yukihiko Sugimoto; Atsushi Ichikawa; Sachiko Oh-Ishi
Major roles of prostanoid receptors IP and EP(3) in endotoxin-induced enhancement of pain perception.
Biochemical pharmacology 2001;62(2):157-60.
2001: Shuh Narumiya; garret fitzgerald
Genetic and pharmacological analysis of prostanoid receptor function.
The Journal of clinical investigation 2001;108(1):25-30.
2001: Toshiaki Minami; H Nakano; T Kobayashi; Y Sugimoto; Fumitaka Ushikubi; A Ichikawa; Shuh Narumiya; Seiji Ito
Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice.
British journal of pharmacology 2001;133(3):438-44.
2001: S Shinomiya; Hiroaki Naraba; Akinori Ueno; I Utsunomiya; Takayuki Maruyama; Shuichi Ohuchida; Fumitaka Ushikubi; K Yuki; Shuh Narumiya; Yukihiko Sugimoto; Atsushi Ichikawa; Sachiko Oh-Ishi
Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists.
Biochemical pharmacology 2001;61(9):1153-60.
2001: Takayuki Kato; Naoki Watanabe; Y Morishima; A Fujita; Toshimasa Ishizaki; Shuh Narumiya
Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells.
Journal of cell science 2001;114(Pt 4):775-84.
2001: K Boku; Takashi Ohno; Takeo Saeki; H Hayashi; Izumi Hayashi; Makoto Katori; T Murata; Shuh Narumiya; Katsunori Saigenji; Masataka Majima
Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves.
Gastroenterology 2001;120(1):134-43.
2001: Toshimasa Ishizaki; Yosuke Morishima; Muneo Okamoto; Tomoyuki Furuyashiki; Takayuki Kato; Shuh Narumiya
Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1.
Nature cell biology 2001;3(1):8-14.
2001: Megumi Honjo; Hidenobu Tanihara; Masaru Inatani; Noriaki Kido; Tatsuya Sawamura; Beatrice Y J T Yue; Shuh Narumiya; Yoshihito Honda
Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility.
Investigative ophthalmology & visual science 2001;42(1):137-44.
2000: Yoko Sakuma; Kiyoji Tanaka; Michio Suda; Yasato Komatsu; Akihiro Yasoda; Masako Miura; Ami Ozasa; Shuh Narumiya; Yukihiko Sugimoto; Atsushi Ichikawa; Fumitaka Ushikubi; Kazuwa Nakao
Impaired bone resorption by lipopolysaccharide in vivo in mice deficient in the prostaglandin E receptor EP4 subtype.
Infection and immunity 2000;68(12):6819-25.
2000: M Kotani; Issei Tanaka; Yoshihiro Ogawa; Takayoshi Suganami; Toshio Matsumoto; Shigeo Muro; Y Yamamoto; Akira Sugawara; Yasunao Yoshimasa; Norimasa Sagawa; Shuh Narumiya; Kazuwa Nakao
Multiple signal transduction pathways through two prostaglandin E receptor EP3 subtype isoforms expressed in human uterus.
The Journal of clinical endocrinology and metabolism 2000;85(11):4315-22.
2000: Yuji Okada; Akiyoshi Hara; Hong Ma; Chun-Yang Xiao; Osamu Takahata; Y Kohgo; Shuh Narumiya; Fumitaka Ushikubi
Characterization of prostanoid receptors mediating contraction of the gastric fundus and ileum: studies using mice deficient in prostanoid receptors.
British journal of pharmacology 2000;131(4):745-55.
2000: Takuya Kobayashi; Fumitaka Ushikubi; Shuh Narumiya
Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis.
The Journal of biological chemistry 2000;275(32):24294-303.
2000: Shigeo Muro; Issei Tanaka; Takeshi Usui; M Kotani; S Koide; Masashi Mukoyama; J Fukata; Hiroaki Itoh; Shuh Narumiya; M Kawata; Kazuwa Nakao
Expression of prostaglandin E receptor EP4 subtype in rat adrenal zona glomerulosa: involvement in aldosterone release.
Endocrine journal 2000;47(4):429-36.
2000: Fumitaka Ushikubi; Y Sugimoto; A Ichikawa; Shuh Narumiya
Roles of prostanoids revealed from studies using mice lacking specific prostanoid receptors.
Japanese journal of pharmacology 2000;83(4):279-85.
2000: Kouji Watanabe; Toshihiko Kawamori; Seiichi Nakatsugi; Toshihisa Ohta; Shuichi Ohuchida; Hiroshi Yamamoto; Takayuki Maruyama; Kigen Kondo; Shuh Narumiya; Takashi Sugimura; Keiji Wakabayashi
Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice.
Cancer letters 2000;156(1):57-61.
2000: Yukihiko Sugimoto; Shuh Narumiya; Atsushi Ichikawa
Distribution and function of prostanoid receptors: studies from knockout mice.
Progress in lipid research 2000;39(4):289-314.
2000: Kazushi Kimura; T Tsuji; Y Takada; Tsuneharu Miki; Shuh Narumiya
Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation.
The Journal of biological chemistry 2000;275(23):17233-6.
2000: Haruhiko Bito; Tomoyuki Furuyashiki; H Ishihara; Y Shibasaki; K Ohashi; Kensaku Mizuno; M Maekawa; Toshimasa Ishizaki; Shuh Narumiya
A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons.
Neuron 2000;26(2):431-41.
2000: Toshimasa Ishizaki; Masayoshi Uehata; I Tamechika; Jeongsin Keel; K Nonomura; M Maekawa; Shuh Narumiya
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.
Molecular pharmacology 2000;57(5):976-83.
2000: P Madaule; Tomoyuki Furuyashiki; M Eda; Haruhiko Bito; Toshimasa Ishizaki; Shuh Narumiya
Citron, a Rho target that affects contractility during cytokinesis.
Microscopy research and technique 2000;49(2):123-6.
2000: Fumitaka Ushikubi; Shuh Narumiya
[Analysis of the mice lacking the prostanoid receptor].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(6 Suppl):909-20.
2000: Shuh Narumiya
[Signal transduction and therapeutic strategies].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(6 Suppl):827-32.
2000: Toshiyuki Matsuoka; Masakazu Hirata; Hajime Tanaka; Y Takahashi; Takahiko Murata; Kenji Kabashima; Yukihiko Sugimoto; Takuya Kobayashi; Fumitaka Ushikubi; Y Aze; Naomi Eguchi; Yoshihiro Urade; Nobuaki Yoshida; K Kimura; Akira Mizoguchi; Y Honda; Hiroichi Nagai; Shuh Narumiya
Prostaglandin D2 as a mediator of allergic asthma.
Science (New York, N.Y.) 2000;287(5460):2013-7.
2000: Michio Suda; Kiyoji Tanaka; Yoko Sakuma; Akihiro Yasoda; Ami Ozasa; J Fukata; Issei Tanaka; Shuh Narumiya; Kazuwa Nakao
Prostaglandin E(2) (PGE(2)) induces the c-fos and c-jun expressions via the EP(1) subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells.
Calcified tissue international 2000;66(3):217-23.
2000: Akinori Ueno; Hiroaki Naraba; Y Ikeda; Fumitaka Ushikubi; T Murata; Shuh Narumiya; Sachiko Oh-Ishi
Intrinsic prostacyclin contributes to exudation induced by bradykinin or carrageenin: a study on the paw edema induced in IP-receptor-deficient mice.
Life sciences 2000;66(12):PL155-60.
2000: Yoko Sakuma; Kiyoji Tanaka; Michio Suda; Akihiro Yasoda; Koshi Natsui; Issei Tanaka; Fumitaka Ushikubi; Shuh Narumiya; Eri Segi; Yukihiko Sugimoto; Atsushi Ichikawa; Kazuwa Nakao
Crucial involvement of the EP4 subtype of prostaglandin E receptor in osteoclast formation by proinflammatory cytokines and lipopolysaccharide.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(2):218-27.
2000: Shuh Narumiya; Toshimasa Ishizaki; Masayoshi Uehata
Use and properties of ROCK-specific inhibitor Y-27632.
Methods in enzymology 2000;325():273-84.
2000: A Fujita; Kozo Nakamura; Takayuki Kato; Naoki Watanabe; Toshimasa Ishizaki; Kazuhiro Kimura; A Mizoguchi; Shuh Narumiya
Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella.
Journal of cell science 2000;113 ( Pt 1)():103-12.
1999: Kouji Watanabe; Toshihiko Kawamori; Seiichi Nakatsugi; Toshihisa Ohta; Shuichi Ohuchida; Hiroshi Yamamoto; Takayuki Maruyama; Kigen Kondo; Fumitaka Ushikubi; Shuh Narumiya; Takashi Sugimura; Keiji Wakabayashi
Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.
Cancer research 1999;59(20):5093-6.
1999: Takuya Kobayashi; Fumitaka Ushikubi; Shuh Narumiya
[Determination of ligand binding domains of the prostanoid receptors].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():127P-129P.
1999: Shuh Narumiya
[Cellular functions & pharmacological manipulations of the small GTPase Rho & Rho effectors].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():1P-5P.
1999: Shuh Narumiya; Yukihiko Sugimoto; Fumitaka Ushikubi
Prostanoid receptors: structures, properties, and functions.
Physiological reviews 1999;79(4):1193-226.
1999: Y Shiraishi; A Mizutani; Haruhiko Bito; K Fujisawa; Shuh Narumiya; Katsuhiko Mikoshiba; T Furuichi
Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(19):8389-400.
1999: H Hizaki; Eri Segi; Yukihiko Sugimoto; M Hirose; T Saji; Fumitaka Ushikubi; Toshiyuki Matsuoka; Y Noda; Tetsuaki Tanaka; Nobuaki Yoshida; Shuh Narumiya; Atsushi Ichikawa
Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2).
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10501-6.
1999: M Maekawa; Toshimasa Ishizaki; S Boku; Naoki Watanabe; Akiko Fujita; A Iwamatsu; T Obinata; K Ohashi; Kensaku Mizuno; Shuh Narumiya
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Science (New York, N.Y.) 1999;285(5429):895-8.
1999: Rieko Ishibashi; Issei Tanaka; M Kotani; Shigeo Muro; Masahisa Goto; Akira Sugawara; Masashi Mukoyama; Yukihiko Sugimoto; Atsushi Ichikawa; Shuh Narumiya; Kazuwa Nakao
Roles of prostaglandin E receptors in mesangial cells under high-glucose conditions.
Kidney international 1999;56(2):589-600.
1999: Naoki Watanabe; Takayuki Kato; A Fujita; Toshimasa Ishizaki; Shuh Narumiya
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization.
Nature cell biology 1999;1(3):136-43.
1999: Kozo Nakamura; A Fujita; T Murata; Go Watanabe; Chisato Mori; Jun Fujita; Naoki Watanabe; Toshimasa Ishizaki; O Yoshida; Shuh Narumiya
Rhophilin, a small GTPase Rho-binding protein, is abundantly expressed in the mouse testis and localized in the principal piece of the sperm tail.
FEBS letters 1999;445(1):9-13.
1999: S Ohishi; Akinori Ueno; H Matsumoto; T Murata; Fumitaka Ushikubi; Shuh Narumiya
Evidence for involvement of prostaglandin I2 as a major nociceptive mediator in acetic acid-induced writhing reaction: a study using IP-receptor disrupted mice.
Advances in experimental medicine and biology 1999;469():265-8.
1999: Tomoyuki Furuyashiki; K Fujisawa; A Fujita; P Madaule; S Uchino; Masayoshi Mishina; Haruhiko Bito; Shuh Narumiya
Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(1):109-18.
1998: Fumitaka Ushikubi; Eri Segi; Yukihiko Sugimoto; Takahiko Murata; Toshiyuki Matsuoka; Takuya Kobayashi; H Hizaki; K Tuboi; Masato Katsuyama; Atsushi Ichikawa; Tetsuaki Tanaka; Nobuaki Yoshida; Shuh Narumiya
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3.
Nature 1998;395(6699):281-4.
1998: P Madaule; M Eda; Naoki Watanabe; K Fujisawa; Toshiyuki Matsuoka; Haruhiko Bito; Toshimasa Ishizaki; Shuh Narumiya
Role of citron kinase as a target of the small GTPase Rho in cytokinesis.
Nature 1998;394(6692):491-4.
1998: K Fujisawa; P Madaule; Toshimasa Ishizaki; Go Watanabe; Haruhiko Bito; Yoshihiko Saito; Alan Hall; Shuh Narumiya
Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules.
The Journal of biological chemistry 1998;273(30):18943-9.
1998: M Hirose; Toshimasa Ishizaki; Naoki Watanabe; Masayoshi Uehata; Onno Kranenburg; Wouter H Moolenaar; F Matsumura; M Maekawa; Haruhiko Bito; Shuh Narumiya
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells.
The Journal of cell biology 1998;141(7):1625-36.
1998: M Yamaguchi; M Nakamoto; H Honda; Taro Nakagawa; H Fujita; Tetsuya Nakamura; Hisamaru Hirai; Shuh Narumiya; Akira Kakizuka
Retardation of skeletal development and cervical abnormalities in transgenic mice expressing a dominant-negative retinoic acid receptor in chondrogenic cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7491-6.
1998: Eri Segi; Yukihiko Sugimoto; A Yamasaki; Y Aze; Hiroji Oida; T Nishimura; Takahiko Murata; Toshiyuki Matsuoka; Fumitaka Ushikubi; M Hirose; Tetsuaki Tanaka; Nobuaki Yoshida; Shuh Narumiya; Atsushi Ichikawa
Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice.
Biochemical and biophysical research communications 1998;246(1):7-12.
1998: Michio Suda; Kiyoji Tanaka; Akihiro Yasoda; Koshi Natsui; Yoko Sakuma; Issei Tanaka; Fumitaka Ushikubi; Shuh Narumiya; Kazuwa Nakao
Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells.
Calcified tissue international 1998;62(4):327-31.
1998: Yukihiko Sugimoto; Eri Segi; Kazuhito Tsuboi; Atsushi Ichikawa; Shuh Narumiya
Female reproduction in mice lacking the prostaglandin F receptor. Roles of prostaglandin and oxytocin receptors in parturition.
Advances in experimental medicine and biology 1998;449():317-21.
1998: Hirofumi Suwa; Gakuji Ohshio; T Imamura; Go Watanabe; Shigeki Arii; Masayuki Imamura; Shuh Narumiya; Hiroshi Hiai; M Fukumoto
Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.
British journal of cancer 1998;77(1):147-52.
1997: Hiroji Oida; Masakazu Hirata; Yukihiko Sugimoto; Fumitaka Ushikubi; H Ohishi; N Mizuno; Atsushi Ichikawa; Shuh Narumiya
Expression of messenger RNA for the prostaglandin D receptor in the leptomeninges of the mouse brain.
FEBS letters 1997;417(1):53-6.
1997: M Kiriyama; Fumitaka Ushikubi; Takuya Kobayashi; Masakazu Hirata; Yukihiko Sugimoto; Shuh Narumiya
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
British journal of pharmacology 1997;122(2):217-24.
1997: Takahiko Murata; Fumitaka Ushikubi; Toshiyuki Matsuoka; Masakazu Hirata; A Yamasaki; Yukihiko Sugimoto; Atsushi Ichikawa; Y Aze; Tetsuaki Tanaka; Nobuaki Yoshida; Akinori Ueno; Sachiko Oh-Ishi; Shuh Narumiya
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor.
Nature 1997;388(6643):678-82.
1997: Y Sasaki; T Takahashi; Issei Tanaka; K Nakamura; Y Okuno; O Nakagawa; Shuh Narumiya; Kazuwa Nakao
Expression of prostacyclin receptor in human megakaryocytes.
Blood 1997;90(3):1039-46.
1997: Yukihiko Sugimoto; A Yamasaki; Eri Segi; Kazuhito Tsuboi; Y Aze; T Nishimura; Hiroji Oida; Nobuaki Yoshida; Tetsuaki Tanaka; Masato Katsuyama; K Hasumoto; Takahiko Murata; Masakazu Hirata; Fumitaka Ushikubi; Manabu Negishi; Atsushi Ichikawa; Shuh Narumiya
Failure of parturition in mice lacking the prostaglandin F receptor.
Science (New York, N.Y.) 1997;277(5326):681-3.
1997: Shuh Narumiya; Toshimasa Ishizaki; Naoki Watanabe
Rho effectors and reorganization of actin cytoskeleton.
FEBS letters 1997;410(1):68-72.
1997: Takuya Kobayashi; M Kiriyama; T Hirata; Masakazu Hirata; Fumitaka Ushikubi; Shuh Narumiya
Identification of domains conferring ligand binding specificity to the prostanoid receptor. Studies on chimeric prostacyclin/prostaglandin D receptors.
The Journal of biological chemistry 1997;272(24):15154-60.
1997: Naoki Watanabe; P Madaule; T Reid; Toshimasa Ishizaki; Go Watanabe; Akira Kakizuka; Yoshihiko Saito; Kazuwa Nakao; B M Jockusch; Shuh Narumiya
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.
The EMBO journal 1997;16(11):3044-56.
1997: M Kotani; Issei Tanaka; Yoshihiro Ogawa; Takeshi Usui; N Tamura; Kazuhiro J Mori; Shuh Narumiya; T Yoshimi; Kazuwa Nakao
Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3).
Genomics 1997;40(3):425-34.
1997: Toshimasa Ishizaki; M Naito; K Fujisawa; M Maekawa; Naoki Watanabe; Yoshihiko Saito; Shuh Narumiya
p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions.
FEBS letters 1997;404(2-3):118-24.
1997: K Morimoto; Yukihiko Sugimoto; Masato Katsuyama; Hiroji Oida; Kazuhito Tsuboi; K Kishi; Yoshikazu Kinoshita; Manabu Negishi; Tsutomu Chiba; Shuh Narumiya; Atsushi Ichikawa
Cellular localization of mRNAs for prostaglandin E receptor subtypes in mouse gastrointestinal tract.
The American journal of physiology 1997;272(3 Pt 1):G681-7.
1997: Shuh Narumiya
Molecular diversity of prostanoid receptors; subtypes and isoforms of prostaglandin E receptor.
Advances in experimental medicine and biology 1997;400A():207-13.
1996: K Fujisawa; A Fujita; Toshimasa Ishizaki; Yoshihiko Saito; Shuh Narumiya
Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase.
The Journal of biological chemistry 1996;271(38):23022-8.
1996: H Takebayashi; Hiroji Oida; K Fujisawa; M Yamaguchi; T Hikida; M Fukumoto; Shuh Narumiya; Akira Kakizuka
Hormone-induced apoptosis by Fas-nuclear receptor fusion proteins: novel biological tools for controlling apoptosis in vivo.
Cancer research 1996;56(18):4164-70.
1996: O Nakagawa; K Fujisawa; Toshimasa Ishizaki; Yoshihiko Saito; Kazuwa Nakao; Shuh Narumiya
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice.
FEBS letters 1996;392(2):189-93.
1996: Shuh Narumiya
The small GTPase Rho: cellular functions and signal transduction.
Journal of biochemistry 1996;120(2):215-28.
1996: T Reid; T Furuyashiki; Toshimasa Ishizaki; Go Watanabe; Naoki Watanabe; K Fujisawa; N Morii; P Madaule; Shuh Narumiya
Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain.
The Journal of biological chemistry 1996;271(23):13556-60.
1996: Kazuhiro J Mori; Issei Tanaka; M Kotani; F Miyaoka; T Sando; Shigeo Muro; Y Sasaki; O Nakagawa; Yoshihiro Ogawa; Takeshi Usui; S Ozaki; Atsushi Ichikawa; Shuh Narumiya; Kazuwa Nakao
Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester.
Journal of molecular medicine (Berlin, Germany) 1996;74(6):333-6.
1996: H Ikeda; M Yamaguchi; S Sugai; Y Aze; Shuh Narumiya; Akira Kakizuka
Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo.
Nature genetics 1996;13(2):196-202.
1996: Michio Suda; K Tanaka; Koshi Natsui; Takeshi Usui; Issei Tanaka; M Fukushima; Chohei Shigeno; Junji Konishi; Shuh Narumiya; Atsushi Ichikawa; N Nakao
Prostaglandin E receptor subtypes in mouse osteoblastic cell line.
Endocrinology 1996;137(5):1698-705.
1996: Toshimasa Ishizaki; M Maekawa; K Fujisawa; K Okawa; A Iwamatsu; A Fujita; Naoki Watanabe; Yoshihiko Saito; A Kakizuka; N Morii; Shuh Narumiya
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
The EMBO journal 1996;15(8):1885-93.
1996: T Momiyama; N Todo; Yukihiko Sugimoto; Atsushi Ichikawa; Shuh Narumiya
Membrane depolarization by activation of prostaglandin E receptor EP3 subtype of putative serotonergic neurons in the dorsal raphe nucleus of the rat.
Naunyn-Schmiedeberg's archives of pharmacology 1996;353(4):377-81.
1996: T Hirata; Fumitaka Ushikubi; Akira Kakizuka; M Okuma; Shuh Narumiya
Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.
The Journal of clinical investigation 1996;97(4):949-56.
1996: Go Watanabe; Yoshihiko Saito; P Madaule; Toshimasa Ishizaki; K Fujisawa; N Morii; H Mukai; Y Ono; A Kakizuka; Shuh Narumiya
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho.
Science (New York, N.Y.) 1996;271(5249):645-8.
1996: M Okuma; T Hirata; Fumitaka Ushikubi; Akira Kakizuka; Shuh Narumiya
Molecular characterization of a dominantly inherited bleeding disorder with impaired platelet responses to thromboxane A2.
Polish journal of pharmacology 1996;48(1):77-82.
1996: Shuh Narumiya
Prostanoid receptors and signal transduction.
Progress in brain research 1996;113():231-41.
1995: P Madaule; T Furuyashiki; T Reid; Toshimasa Ishizaki; Go Watanabe; N Morii; Shuh Narumiya
A novel partner for the GTP-bound forms of rho and rac.
FEBS letters 1995;377(2):243-8.
1995: O Nakagawa; Y Sasaki; Issei Tanaka; Takeshi Usui; T Sando; Shigeo Muro; Kazuhiro J Mori; H Itoh; T Yoshimasa; Shuh Narumiya
Gene expression of prostacyclin receptor in the hypertrophied heart of spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology. Supplement 1995;22(1):S270-2.
1995: Hiroji Oida; T Namba; Yukihiko Sugimoto; Fumitaka Ushikubi; H Ohishi; Atsushi Ichikawa; Shuh Narumiya
In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs.
British journal of pharmacology 1995;116(7):2828-37.
1995: Yukihiko Sugimoto; Manabu Negishi; Fumitaka Ushikubi; Shuh Narumiya; Atsushi Ichikawa
[Molecular structure and function of the prostanoid receptors].
Seikagaku. The Journal of Japanese Biochemical Society 1995;67(12):1351-65.
1995: M Kotani; Issei Tanaka; Yoshihiro Ogawa; Takeshi Usui; Kazuhiro J Mori; Atsushi Ichikawa; Shuh Narumiya; T Yoshimi; Kazuwa Nakao
Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions.
Molecular pharmacology 1995;48(5):869-79.
1995: M Hirata; Fumitaka Ushikubi; Shuh Narumiya
Prostaglandin I receptor and prostaglandin D receptor.
Journal of lipid mediators and cell signalling 1995;12(2-3):393-404.
1995: Fumitaka Ushikubi; M Hirata; Shuh Narumiya
Molecular biology of prostanoid receptors; an overview.
Journal of lipid mediators and cell signalling 1995;12(2-3):343-59.
1995: Masato Katsuyama; N Nishigaki; Yukihiko Sugimoto; K Morimoto; Manabu Negishi; Shuh Narumiya; Atsushi Ichikawa
The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysis.
FEBS letters 1995;372(2-3):151-6.
1995: Yoshihiko Saito; Y Nemoto; Toshimasa Ishizaki; Naoki Watanabe; N Morii; Shuh Narumiya
Identification of Glu173 as the critical amino acid residue for the ADP-ribosyltransferase activity of Clostridium botulinum C3 exoenzyme.
FEBS letters 1995;371(2):105-9.
1995: H Hirakata; Fumitaka Ushikubi; Shuh Narumiya; Y Hatano; K Nakamura; Kazuhiro J Mori
The effect of inhaled anesthetics on the platelet aggregation and the ligand-binding affinity of the platelet thromboxane A2 receptor.
Anesthesia and analgesia 1995;81(1):114-8.
1995: N Kumagai; N Morii; Toshimasa Ishizaki; Naoki Watanabe; K Fujisawa; Yoshihiko Saito; Shuh Narumiya
Lysophosphatidic acid-induced activation of protein Ser/Thr kinases in cultured rat 3Y1 fibroblasts. Possible involvement in rho p21-mediated signalling.
FEBS letters 1995;366(1):11-6.
1995: N Nishigaki; Manabu Negishi; A Honda; Yukihiko Sugimoto; T Namba; Shuh Narumiya; Atsushi Ichikawa
Identification of prostaglandin E receptor 'EP2' cloned from mastocytoma cells EP4 subtype.
FEBS letters 1995;364(3):339-41.
1995: Yoshihiro Ogawa; Issei Tanaka; Mayumi Inoue; Y Yoshitake; N Isse; O Nakagawa; Takeshi Usui; H Itoh; T Yoshimasa; Shuh Narumiya
Structural organization and chromosomal assignment of the human prostacyclin receptor gene.
Genomics 1995;27(1):142-8.
1995: S Ishiguro; Shigeki Arii; Koichi Monden; Satoshi Fujita; T Nakamura; M Niwano; T Harada; Fumitaka Ushikubi; Shuh Narumiya; Masayuki Imamura
Involvement of thromboxane A2-thromboxane A2 receptor system of the hepatic sinusoid in pathogenesis of cold preservation/reperfusion injury in the rat liver graft.
Transplantation 1995;59(7):957-61.
1995: M Saitou; S Sugai; T Tanaka; K Shimouchi; E Fuchs; Shuh Narumiya; Akira Kakizuka
Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor.
Nature 1995;374(6518):159-62.
1995: Manabu Negishi; Yukihiko Sugimoto; T Namba; A Irie; Shuh Narumiya; Atsushi Ichikawa
Signal transductions of three isoforms of mouse prostaglandin E receptor EP3 subtype.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():255-7.
1995: Shuh Narumiya
Structures, properties and distributions of prostanoid receptors.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():17-22.
1995: N Morii; Shuh Narumiya
Preparation of native and recombinant Clostridium botulinum C3 ADP-ribosyltransferase and identification of Rho proteins by ADP-ribosylation.
Methods in enzymology 1995;256():196-206.
1994: Y Sasaki; Takeshi Usui; Issei Tanaka; O Nakagawa; T Sando; T Takahashi; T Namba; Shuh Narumiya; Kazuwa Nakao
Cloning and expression of a cDNA for rat prostacyclin receptor.
Biochimica et biophysica acta 1994;1224(3):601-5.
1994: Shuh Narumiya
Prostanoid receptors. Structure, function, and distribution.
Annals of the New York Academy of Sciences 1994;744():126-38.
1994: M Hirata; Akira Kakizuka; M Aizawa; Fumitaka Ushikubi; Shuh Narumiya
Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11192-6.
1994: Fumitaka Ushikubi; K Nakamura; Shuh Narumiya
Functional reconstitution of platelet thromboxane A2 receptors with Gq and Gi2 in phospholipid vesicles.
Molecular pharmacology 1994;46(5):808-16.
1994: T Hirata; Akira Kakizuka; Fumitaka Ushikubi; Ichiro Fuse; M Okuma; Shuh Narumiya
Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.
The Journal of clinical investigation 1994;94(4):1662-7.
1994: O Nakagawa; Issei Tanaka; Takeshi Usui; Masaki Harada; Y Sasaki; H Itoh; T Yoshimasa; T Namba; Shuh Narumiya; Kazuwa Nakao
Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.
Circulation 1994;90(4):1643-7.
1994: Yukihiko Sugimoto; Ryuichi Shigemoto; T Namba; Manabu Negishi; Noboru Mizuno; Shuh Narumiya; Atsushi Ichikawa
Distribution of the messenger RNA for the prostaglandin E receptor subtype EP3 in the mouse nervous system.
Neuroscience 1994;62(3):919-28.
1994: Shuh Narumiya; N Morii
[rho p21 in cell cycle progression].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1994;39(10):1673-7.
1994: M Saitou; Shuh Narumiya; Akira Kakizuka
Alteration of a single amino acid residue in retinoic acid receptor causes dominant-negative phenotype.
The Journal of biological chemistry 1994;269(29):19101-7.
1994: T Sando; Takeshi Usui; Issei Tanaka; Kazuhiro J Mori; Y Sasaki; Y Fukuda; T Namba; Yukihiko Sugimoto; Atsushi Ichikawa; Shuh Narumiya
Molecular cloning and expression of rat prostaglandin E receptor EP2 subtype.
Biochemical and biophysical research communications 1994;200(3):1329-33.
1994: Masato Katsuyama; Yukihiko Sugimoto; T Namba; A Irie; Manabu Negishi; Shuh Narumiya; Atsushi Ichikawa
Cloning and expression of a cDNA for the human prostacyclin receptor.
FEBS letters 1994;344(1):74-8.
1994: Yukihiko Sugimoto; T Namba; Ryuichi Shigemoto; Manabu Negishi; Atsushi Ichikawa; Shuh Narumiya
Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney.
The American journal of physiology 1994;266(5 Pt 2):F823-8.
1994: T Namba; Hiroji Oida; Yukihiko Sugimoto; Akira Kakizuka; Manabu Negishi; Atsushi Ichikawa; Shuh Narumiya
cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla.
The Journal of biological chemistry 1994;269(13):9986-92.
1994: Yukihiko Sugimoto; K Hasumoto; T Namba; A Irie; Masato Katsuyama; Manabu Negishi; Akira Kakizuka; Shuh Narumiya; Atsushi Ichikawa
Cloning and expression of a cDNA for mouse prostaglandin F receptor.
The Journal of biological chemistry 1994;269(2):1356-60.
1993: N Morii; N Kumagai; M S Nur-E-Kamal; Shuh Narumiya; H Maruta
rho GAP of 28 kDa (GAP2), but not of 190 kDa (p190), requires Asp65 and Asp67 of rho GTPase for its activation.
The Journal of biological chemistry 1993;268(36):27160-3.
1993: Manabu Negishi; T Namba; Yukihiko Sugimoto; A Irie; Toshiaki Katada; Shuh Narumiya; Atsushi Ichikawa
Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o).
The Journal of biological chemistry 1993;268(35):26067-70.
1993: R M Nüsing; M Hirata; Akira Kakizuka; T Eki; K Ozawa; Shuh Narumiya
Characterization and chromosomal mapping of the human thromboxane A2 receptor gene.
The Journal of biological chemistry 1993;268(33):25253-9.
1993: N Kumagai; N Morii; K Fujisawa; Y Nemoto; Shuh Narumiya
ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.
The Journal of biological chemistry 1993;268(33):24535-8.
1993: Fumitaka Ushikubi; Y Aiba; K Nakamura; T Namba; M Hirata; O Mazda; Yoshimoto Katsura; Shuh Narumiya
Thromboxane A2 receptor is highly expressed in mouse immature thymocytes and mediates DNA fragmentation and apoptosis.
The Journal of experimental medicine 1993;178(5):1825-30.
1993: A Irie; Yukihiko Sugimoto; T Namba; A Harazono; A Honda; A Watabe; Manabu Negishi; Shuh Narumiya; Atsushi Ichikawa
Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase.
European journal of biochemistry / FEBS 1993;217(1):313-8.
1993: A Watabe; Yukihiko Sugimoto; A Honda; A Irie; T Namba; Manabu Negishi; S Ito; Shuh Narumiya; Atsushi Ichikawa
Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor.
The Journal of biological chemistry 1993;268(27):20175-8.
1993: T Namba; Yukihiko Sugimoto; Manabu Negishi; A Irie; Fumitaka Ushikubi; Akira Kakizuka; S Ito; Atsushi Ichikawa; Shuh Narumiya
Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity.
Nature 1993;365(6442):166-70.
1993: N Nishigaki; Manabu Negishi; Yukihiko Sugimoto; T Namba; Shuh Narumiya; Atsushi Ichikawa
Characterization of the prostaglandin E receptor expressed on a cultured mast cell line, BNu-2cl3.
Biochemical pharmacology 1993;46(5):863-9.
1993: N Kumagai; N Morii; K Fujisawa; T Yoshimasa; Kazuwa Nakao; Shuh Narumiya
Lysophosphatidic acid induces tyrosine phosphorylation and activation of MAP-kinase and focal adhesion kinase in cultured Swiss 3T3 cells.
FEBS letters 1993;329(3):273-6.
1993: M Yamamoto; N Marui; T Sakai; N Morii; Shunji Kozaki; Kohichi Ikai; Sadao Imamura; Shuh Narumiya
ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle.
Oncogene 1993;8(6):1449-55.
1993: M Hirata; Fumitaka Ushikubi; Shuh Narumiya
[Structure and function of the prostanoid receptors in cardiovascular system].
Nihon rinsho. Japanese journal of clinical medicine 1993;51(6):1586-90.
1993: Toru Kita; Masayuki Yokode; Hidenori Arai; M Iiyama; Y Ueda; K Ueyama; Shuh Narumiya
Cigarette smoke, LDL and cholesteryl ester accumulation in macrophages. Implications for atherosclerosis.
Annals of the New York Academy of Sciences 1993;686():91-6; discussion 97-8.
1993: Manabu Negishi; Yukihiko Sugimoto; A Irie; Shuh Narumiya; Atsushi Ichikawa
Two isoforms of prostaglandin E receptor EP3 subtype. Different COOH-terminal domains determine sensitivity to agonist-induced desensitization.
The Journal of biological chemistry 1993;268(13):9517-21.
1993: A Honda; Yukihiko Sugimoto; T Namba; A Watabe; A Irie; Manabu Negishi; Shuh Narumiya; Atsushi Ichikawa
Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype.
The Journal of biological chemistry 1993;268(11):7759-62.
1993: Shuh Narumiya; N Hirata; T Namba; Yukako Hayashi; Fumitaka Ushikubi; Yukihiko Sugimoto; Manabu Negishi; Atsushi Ichikawa
Structure and function of prostanoid receptors.
Journal of lipid mediators 1993;6(1-3):155-61.
1993: T Tominaga; K Sugie; M Hirata; N Morii; J Fukata; A Uchida; Hiroshi Imura; Shuh Narumiya
Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho.
The Journal of cell biology 1993;120(6):1529-37.
1993: Manabu Negishi; Yukihiko Sugimoto; Yukako Hayashi; T Namba; A Honda; A Watabe; Shuh Narumiya; Atsushi Ichikawa
Functional interaction of prostaglandin E receptor EP3 subtype with guanine nucleotide-binding proteins, showing low-affinity ligand binding.
Biochimica et biophysica acta 1993;1175(3):343-50.
1993: Yukihiko Sugimoto; Manabu Negishi; Yukako Hayashi; T Namba; A Honda; A Watabe; M Hirata; Shuh Narumiya; Atsushi Ichikawa
Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins.
The Journal of biological chemistry 1993;268(4):2712-8.
1993: Shuh Narumiya; N Morii
rho gene products, botulinum C3 exoenzyme and cell adhesion.
Cellular signalling 1993;5(1):9-19.
1993: T Namba; Shuh Narumiya
[Thromboxane A2 receptor; structure, function and tissue distribution].
Nihon rinsho. Japanese journal of clinical medicine 1993;51(1):233-40.
1992: N Morii; T Teru-uchi; T Tominaga; N Kumagai; Shunji Kozaki; Fumitaka Ushikubi; Shuh Narumiya
A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation.
The Journal of biological chemistry 1992;267(29):20921-6.
1992: Y Nemoto; T Namba; T Teru-uchi; Fumitaka Ushikubi; N Morii; Shuh Narumiya
A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein.
The Journal of biological chemistry 1992;267(29):20916-20.
1992: Hidenori Arai; Y Nagano; Shuh Narumiya; Toru Kita
Decreased arachidonate metabolism in mouse peritoneal macrophages after foam cell transformation with oxidized low-density lipoproteins.
Journal of biochemistry 1992;112(4):482-7.
1992: T Namba; Yukihiko Sugimoto; M Hirata; Yukako Hayashi; A Honda; A Watabe; Manabu Negishi; Atsushi Ichikawa; Shuh Narumiya
Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis.
Biochemical and biophysical research communications 1992;184(3):1197-203.
1992: Yukihiko Sugimoto; T Namba; A Honda; Yukako Hayashi; Manabu Negishi; Atsushi Ichikawa; Shuh Narumiya
Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype.
The Journal of biological chemistry 1992;267(10):6463-6.
1992: N Morii; Shuh Narumiya
[ras oncogene-related small molecular weight GTP-binding protein, rho gene product and botulinum C3 ADP-ribosyltransferase].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1992;99(4):191-203.
1992: Fumitaka Ushikubi; M Hirata; Shuh Narumiya; M Okuma
[Platelet thromboxane A2 receptor].
Nihon rinsho. Japanese journal of clinical medicine 1992;50(2):264-8.
1992: Fumitaka Ushikubi; T Ishibashi; Shuh Narumiya; M Okuma
Analysis of the defective signal transduction mechanism through the platelet thromboxane A2 receptor in a patient with polycythemia vera.
Thrombosis and haemostasis 1992;67(1):144-6.
1991: Y Nemoto; T Namba; Shunji Kozaki; Shuh Narumiya
Clostridium botulinum C3 ADP-ribosyltransferase gene. Cloning, sequencing, and expression of a functional protein in Escherichia coli.
The Journal of biological chemistry 1991;266(29):19312-9.
1991: N Morii; K Kawano; A Sekine; T Yamada; Shuh Narumiya
Purification of GTPase-activating protein specific for the rho gene products.
The Journal of biological chemistry 1991;266(12):7646-50.
1991: M Hirata; Yukako Hayashi; Fumitaka Ushikubi; Y Yokota; R Kageyama; Shigetada Nakanishi; Shuh Narumiya
Cloning and expression of cDNA for a human thromboxane A2 receptor.
Nature 1991;349(6310):617-20.
1991: Shuh Narumiya; Fumitaka Ushikubi; M Nakajima; M Hirata; M Okuma
Purification and characterization of the human platelet TXA2/PGH2 receptor.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():339-46.
1990: T Nishiki; H Matsuda; Toyoko Hiroi; Yoichi Kamata; Shunji Kozaki; Shuh Narumiya; G Sakaguchi
Morphological effects of Clostridium botulinum C3 exoenzyme on cultured cells.
Japanese journal of medical science & biology 1990;43(6):261-2.
1990: N Morii; Y Ohashi; Y Nemoto; M Fujiwara; Y Ohnishi; T Nishiki; Yoichi Kamata; Shunji Kozaki; Shuh Narumiya; G Sakaguchi
Immunochemical identification of the ADP-ribosyltransferase in botulinum C1 neurotoxin as C3 exoenzyme-like molecule.
Journal of biochemistry 1990;107(5):769-75.
1990: T Nishiki; Shuh Narumiya; N Morii; M Yamamoto; M Fujiwara; Yoichi Kamata; G Sakaguchi; Shunji Kozaki
ADP-ribosylation of the rho/rac proteins induces growth inhibition, neurite outgrowth and acetylcholine esterase in cultured PC-12 cells.
Biochemical and biophysical research communications 1990;167(1):265-72.
1990: Shuh Narumiya; N Morii; A Sekine; Shunji Kozaki
ADP-ribosylation of the rho/rac gene products by botulinum ADP-ribosyltransferase: identity of the enzyme and effects on protein and cell functions.
Journal de physiologie 1990;84(4):267-72.
1989: Fumitaka Ushikubi; M Nakajima; M Hirata; M Okuma; M Fujiwara; Shuh Narumiya
Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets.
The Journal of biological chemistry 1989;264(28):16496-501.
1989: T Ogorochi; Y Nemoto; M Nakajima; E Nakamura; M Fujiwara; Shuh Narumiya
cDNA cloning of Gb, the substrate for botulinum ADP-ribosyltransferase from bovine adrenal gland and its identification as a rho gene product.
Biochemical and biophysical research communications 1989;163(2):1175-81.
1989: A Mikami; K Imoto; T Tanabe; T Niidome; Y Mori; Hiroshi Takeshima; Shuh Narumiya; S Numa
Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel.
Nature 1989;340(6230):230-3.
1989: A Sekine; M Fujiwara; Shuh Narumiya
Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase.
The Journal of biological chemistry 1989;264(15):8602-5.
1989: Hidenori Arai; Toru Kita; Masayuki Yokode; Shuh Narumiya; Chuichi Kawai
Multiple receptors for modified low density lipoproteins in mouse peritoneal macrophages: different uptake mechanisms for acetylated and oxidized low density lipoproteins.
Biochemical and biophysical research communications 1989;159(3):1375-82.
1989: M Nakajima; M Yamamoto; Fumitaka Ushikubi; M Okuma; M Fujiwara; Shuh Narumiya
Expression of thromboxane A2 receptor in cultured human erythroleukemia cells and its induction by 12-O-tetradecanoylphorbol-13-acetate.
Biochemical and biophysical research communications 1989;158(3):958-65.
1989: Fumitaka Ushikubi; M Nakajima; M Yamamoto; K Ohtsu; Y Kimura; M Okuma; H Uchino; M Fujiwara; Shuh Narumiya
[3H]S-145 and [125I]I-S-145-OH: new radioligands for platelet thromboxane A2 receptor with low nonspecific binding and high binding affinity for various receptor preparations.
Eicosanoids 1989;2(1):21-7.
1989: Shuh Narumiya; K Ohno; M Fukushima; M Fujiwara
Cyclopentenone prostaglandins block cell cycle progression in the G1 phase and induce the G1-specific proteins in HeLa S3 cells.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():411-4.
1988: K Ohno; M Fukushima; M Fujiwara; Shuh Narumiya
Induction of 68,000-dalton heat shock proteins by cyclopentenone prostaglandins. Its association with prostaglandin-induced G1 block in cell cycle progression.
The Journal of biological chemistry 1988;263(36):19764-70.
1988: Shuh Narumiya; A Sekine; M Fujiwara
Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product.
The Journal of biological chemistry 1988;263(33):17255-7.
1988: N Morii; A Sekine; Y Ohashi; Kazuwa Nakao; Hiroshi Imura; M Fujiwara; Shuh Narumiya
Purification and properties of the cytosolic substrate for botulinum ADP-ribosyltransferase. Identification as an Mr 22,000 guanine nucleotide-binding protein.
The Journal of biological chemistry 1988;263(25):12420-6.
1988: Toru Kita; Y Nagano; Masayuki Yokode; K Ishii; Noriaki Kume; Shuh Narumiya; Chuichi Kawai
Prevention of atherosclerotic progression in Watanabe rabbits by probucol.
The American journal of cardiology 1988;62(3):13B-19B.
1988: K Ohno; T Sakai; M Fukushima; Shuh Narumiya; M Fujiwara
Site and mechanism of growth inhibition by prostaglandins. IV. Effect of cyclopentenone prostaglandins on cell cycle progression of G1-enriched HeLa S3 cells.
The Journal of pharmacology and experimental therapeutics 1988;245(1):294-8.
1988: Masayuki Yokode; Toru Kita; Hidenori Arai; Chuichi Kawai; Shuh Narumiya; M Fujiwara
Cholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2344-8.
1988: Masayuki Yokode; Toru Kita; Y Kikawa; T Ogorochi; Shuh Narumiya; Chuichi Kawai
Stimulated arachidonate metabolism during foam cell transformation of mouse peritoneal macrophages with oxidized low density lipoprotein.
The Journal of clinical investigation 1988;81(3):720-9.
1988: Shuh Narumiya; N Morii; K Ohno; Y Ohashi; M Fujiwara
Subcellular distribution and isoelectric heterogeneity of the substrate for ADP-ribosyl transferase from Clostridium botulinum.
Biochemical and biophysical research communications 1988;150(3):1122-30.
1987: Shuh Narumiya; M Fukushima
Active transport and cellular accumulation of cyclopentenone prostaglandins: a mechanism of prostaglandin-induced growth inhibition.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17B():972-5.
1987: Masayuki Yokode; Toru Kita; Shuh Narumiya; Chuichi Kawai
Arachidonate metabolism during foam cell transformation of macrophages.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17A():229-32.