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Kim Nasmyth

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Christian S Eichinger; Alexander Kurze; Raquel A Oliveira; Kim Nasmyth
Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis.
Kok-Lung Chan; Bin Hu; Jean Metson; Frédéric Beckouët; Maurici B Roig; Kim Nasmyth
Cohesin's DNA exit gate is distinct from its entrance gate and is regulated by acetylation.
Tim Hunt; Kim Nasmyth; Béla Novák
The cell cycle.

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All Publications

2013: Christian S Eichinger; Alexander Kurze; Raquel A Oliveira; Kim Nasmyth
Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis.
The EMBO journal 2013;32(5):656-65.
2012: Kok-Lung Chan; Bin Hu; Jean Metson; Frédéric Beckouët; Maurici B Roig; Kim Nasmyth
Cohesin's DNA exit gate is distinct from its entrance gate and is regulated by acetylation.
Cell 2012;150(5):961-74.
2011: Tim Hunt; Kim Nasmyth; Béla Novák
The cell cycle.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1584):3494-7.
2011: Ana-Maria Farcas; Wolfgang Helmhart; Pelin Uluocak; Kim Nasmyth
Cohesin's concatenation of sister DNAs maintains their intertwining.
Molecular cell 2011;44(1):97-107.
2011: Kim Nasmyth
Cohesin: a catenase with separate entry and exit gates?
Nature cell biology 2011;13(10):1170-7.
2011: Alexander Kurze; Katharine A Michie; Sarah E Dixon; Ajay Mishra; Takehiko Itoh; Syma Khalid; Lana Strmecki; Katsuhiko Shirahige; Christian H Haering; Jan Löwe; Kim Nasmyth
A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion.
The EMBO journal 2011;30(2):364-78.
2011: Bin Hu; Takehiko Itoh; Ajay Mishra; Yuki Katoh; Kok-Lung Chan; William Upcher; Camilla Godlee; Maurici B Roig; Katsuhiko Shirahige; Kim Nasmyth
ATP hydrolysis is required for relocating cohesin from sites occupied by its Scc2/4 loading complex.
Current biology : CB 2011;21(1):12-24.
2010: Raquel A Oliveira; Kim Nasmyth
Getting through anaphase: splitting the sisters and beyond.
Biochemical Society transactions 2010;38(6):1639-44.
2010: Kim Nasmyth
How far will we see in the future?
Molecular biology of the cell 2010;21(22):3813-4.
2010: Kikuë Tachibana-Konwalski; Jonathan Godwin; Louise van der Weyden; Lysie Champion; Nobuaki R Kudo; David J Adams; Kim Nasmyth
Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes.
Genes & development 2010;24(22):2505-16.
2010: Andrea Pauli; Joke G van Bemmel; Raquel A Oliveira; Takehiko Itoh; Katsuhiko Shirahige; Bas van Steensel; Kim Nasmyth
A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands.
Current biology : CB 2010;20(20):1787-98.
2010: Frederic Beckouët; Bin Hu; Maurici B Roig; Takashi Sutani; Makiko Komata; Pelin Uluocak; Vittorio L Katis; Katsuhiko Shirahige; Kim Nasmyth
An Smc3 acetylation cycle is essential for establishment of sister chromatid cohesion.
Molecular cell 2010;39(5):689-99.
2010: Russell S Hamilton; Richard M Parton; Raquel A Oliveira; Georgia Vendra; Graeme Ball; Kim Nasmyth; Ilan Davis
ParticleStats: open source software for the analysis of particle motility and cytoskeletal polarity.
Nucleic acids research 2010;38(Web Server issue):W641-6.
2010: James Hutchins; Yusuke Toyoda; Björn Hegemann; Ina Poser; Jean-Karim Hériché; Martina M Sykora; Martina Augsburg; Otto Hudecz; Bettina A Buschhorn; Jutta Bulkescher; Christian Conrad; David Comartin; Alexander Schleiffer; Mihail Sarov; Andrei Pozniakovsky; Mikolaj Michal Slabicki; Siegfried Schloissnig; Ines Steinmacher; Marit Leuschner; Andrea Ssykor; Steffen Lawo; Laurence Pelletier; Holger Stark; Kim Nasmyth; Jan Ellenberg; Richard Durbin; Frank Buchholz; Karl Mechtler; Anthony A Hyman; Jan-Michael Peters
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Science (New York, N.Y.) 2010;328(5978):593-9.
2010: Vittorio L Katis; Jesse J Lipp; Richard Imre; Aliona Bogdanova; Elwy Okaz; Bianca Habermann; Karl Mechtler; Kim Nasmyth; Wolfgang Zachariae
Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.
Developmental cell 2010;18(3):397-409.
2010: Ajay Mishra; Bin Hu; Alexander Kurze; Frédéric Beckouët; Ana-Maria Farcas; Sarah E Dixon; Yuki Katou; Syma Khalid; Katsuhiko Shirahige; Kim Nasmyth
Both interaction surfaces within cohesin's hinge domain are essential for its stable chromosomal association.
Current biology : CB 2010;20(4):279-89.
2010: Raquel A Oliveira; Russell S Hamilton; Andrea Pauli; Ilan Davis; Kim Nasmyth
Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei.
Nature cell biology 2010;12(2):185-92.
2010: Kim Nasmyth; R A Oliveira
Splitting the nucleus: what's wrong with the tripartite ring model?
Cold Spring Harbor symposia on quantitative biology 2010;75():375-88.
2009: Zheng Xu; Bulent Cetin; Martin Anger; Uhn Soo Cho; Wolfgang Helmhart; Kim Nasmyth; Wenqing Xu
Structure and function of the PP2A-shugoshin interaction.
Molecular cell 2009;35(4):426-41.
2009: Nobuaki R Kudo; Martin Anger; Antoine H F M Peters; Olaf Stemmann; Hans-Christian Theussl; Wolfgang Helmhart; Hiromi Kudo; Christa Heyting; Kim Nasmyth
Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I.
Journal of cell science 2009;122(Pt 15):2686-98.
2009: Benjamin Rowland; Maurici B Roig; Tatsuya Nishino; Alexander Kurze; Pelin Uluocak; Ajay Mishra; Frédéric Beckouët; Philippa Underwood; Jean Metson; Richard Imre; Karl Mechtler; Vittorio L Katis; Kim Nasmyth
Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity.
Molecular cell 2009;33(6):763-74.
2009: Barry E McGuinness; Martin Anger; Anna Kouznetsova; Ana M Gil-Bernabé; Wolfgang Helmhart; Nobuaki R Kudo; Annelie Wuensche; Stephen Taylor; Christer Hoog; Bela Novak; Kim Nasmyth
Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint.
Current biology : CB 2009;19(5):369-80.
2009: Kim Nasmyth; Christian H Haering
Cohesin: its roles and mechanisms.
Annual review of genetics 2009;43():525-58.
2008: Christian H Haering; Ana-Maria Farcas; Prakash Arumugam; Jean Metson; Kim Nasmyth
The cohesin ring concatenates sister DNA molecules.
Nature 2008;454(7202):297-301.
2008: Ina Poser; Mihail Sarov; James Hutchins; Jean-Karim Hériché; Yusuke Toyoda; Andrei Pozniakovsky; Daniela Weigl; Anja Nitzsche; Björn Hegemann; Alexander W Bird; Laurence Pelletier; Ralf Kittler; Sujun Hua; Ronald Naumann; Martina Augsburg; Martina M Sykora; Helmut Hofemeister; Youming Zhang; Kim Nasmyth; Kevin P White; Steffen Dietzel; Karl Mechtler; Richard Durbin; A Francis Stewart; Jan-Michael Peters; Frank Buchholz; Anthony A Hyman
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals.
Nature methods 2008;5(5):409-15.
2008: Andrea Pauli; Friederike Althoff; Raquel Oliveira; Stefan Heidmann; Oren Schuldiner; Christian F Lehner; Barry J Dickson; Kim Nasmyth
Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons.
Developmental cell 2008;14(2):239-51.
2007: Dmitri Ivanov; Kim Nasmyth
A physical assay for sister chromatid cohesion in vitro.
Molecular cell 2007;27(2):300-10.
2007: Juraj Gregan; Christian G Riedel; Alison L Pidoux; Yuki Katou; Cornelia Rumpf; Alexander Schleiffer; Stephen E Kearsey; Katsuhiko Shirahige; Robin C Allshire; Kim Nasmyth
The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation.
Current biology : CB 2007;17(14):1190-200.
2007: Juraj Gregan; Chao Zhang; Cornelia Rumpf; Lubos Cipak; Zhang Li; Pelin Uluocak; Kim Nasmyth; Kevan M Shokat
Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe.
Nature protocols 2007;2(11):2996-3000.
2007: Juraj Gregan; Christian G Riedel; Mark Petronczki; Lubos Cipak; Cornelia Rumpf; Ina Poser; Frank Buchholz; Karl Mechtler; Kim Nasmyth
Tandem affinity purification of functional TAP-tagged proteins from human cells.
Nature protocols 2007;2(5):1145-51.
2006: Stephan Gruber; Prakash Arumugam; Yuki Katou; Daria Kuglitsch; Wolfgang Helmhart; Katsuhiko Shirahige; Kim Nasmyth
Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge.
Cell 2006;127(3):523-37.
2006: Prakash Arumugam; Tatsuya Nishino; Christian H Haering; Stephan Gruber; Kim Nasmyth
Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit.
Current biology : CB 2006;16(20):1998-2008.
2006: Mark Petronczki; Joao Matos; Saori Mori; Juraj Gregan; Aliona Bogdanova; Martin Schwickart; Karl Mechtler; Katsuhiko Shirahige; Wolfgang Zachariae; Kim Nasmyth
Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1.
Cell 2006;126(6):1049-64.
2006: Nobuaki R Kudo; Katja Wassmann; Martin Anger; Melina Schuh; Karin G Wirth; Huiling Xu; Wolfgang Helmhart; Hiromi Kudo; Michael McKay; Bernard Maro; Jan Ellenberg; Peter de Boer; Kim Nasmyth
Resolution of chiasmata in oocytes requires separase-mediated proteolysis.
Cell 2006;126(1):135-46.
2006: erwan watrin; Alexander Schleiffer; Koichi Tanaka; Frank Eisenhaber; Kim Nasmyth; Jan-Michael Peters
Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.
Current biology : CB 2006;16(9):863-74.
2006: Christian G Riedel; Vittorio L Katis; Yuki Katou; Saori Mori; Takehiko Itoh; Wolfgang Helmhart; Marta Gálová; Mark Petronczki; Juraj Gregan; Bulent Cetin; Ingrid Mudrak; Egon Ogris; Karl Mechtler; Laurence Pelletier; Frank Buchholz; Katsuhiko Shirahige; Kim Nasmyth
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.
Nature 2006;441(7089):53-61.
2006: Karin G Wirth; Gordana Wutz; Nobuaki R Kudo; Chantal Desdouets; Anders Zetterberg; Shahryar Taghybeeglu; Janina Jansong; Germain M Ducos; Romeo Ricci; Nicole Firnberg; Jan-Michael Peters; Kim Nasmyth
Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression.
The Journal of cell biology 2006;172(6):847-60.
2006: Juraj Gregan; Peter K Rabitsch; Cornelia Rumpf; Maria Novatchkova; Alexander Schleiffer; Kim Nasmyth
High-throughput knockout screen in fission yeast.
Nature protocols 2006;1(5):2457-64.
2005: Sabine Vaur; fabien cubizolles; Guillaume Plane; Sylvie Genier; Peter K Rabitsch; Juraj Gregan; Kim Nasmyth; Vincent Vanoosthuyse; Kevin G Hardwick; Jean-Paul Javerzat
Control of Shugoshin function during fission-yeast meiosis.
Current biology : CB 2005;15(24):2263-70.
2005: Dmitri Ivanov; Kim Nasmyth
A topological interaction between cohesin rings and a circular minichromosome.
Cell 2005;122(6):849-60.
2005: Juraj Gregan; Peter K Rabitsch; Benjamin Sakem; Ortansa Csutak; Vitaly Latypov; Elisabeth Lehmann; Jürg Kohli; Kim Nasmyth
Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.
Current biology : CB 2005;15(18):1663-9.
2005: Olivier Hamant; Inna N Golubovskaya; Robert B Meeley; Elisa Fiume; Ljudmilla Timofejeva; Alexander Schleiffer; Kim Nasmyth; W Zacheus Cande
A REC8-dependent plant Shugoshin is required for maintenance of centromeric cohesion during meiosis and has no mitotic functions.
Current biology : CB 2005;15(10):948-54.
2005: Kim Nasmyth
How might cohesin hold sister chromatids together?
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005;360(1455):483-96.
2005: Mitsuhiro Yanagida; Kim Nasmyth
Introduction: dissection and simplification of chromosome segregation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005;360(1455):481.
2005: Kim Nasmyth
How do so few control so many?
Cell 2005;120(6):739-46.
2005: Barry E McGuinness; Toru Hirota; Nobuaki R Kudo; Jan-Michael Peters; Kim Nasmyth
Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells.
PLoS biology 2005;3(3):e86.
2005: Kim Nasmyth; Christian H Haering
The structure and function of SMC and kleisin complexes.
Annual review of biochemistry 2005;74():595-648.
2004: Vittorio L Katis; Joao Matos; Saori Mori; Katsuhiko Shirahige; Wolfgang Zachariae; Kim Nasmyth
Spo13 facilitates monopolin recruitment to kinetochores and regulates maintenance of centromeric cohesion during yeast meiosis.
Current biology : CB 2004;14(24):2183-96.
2004: Doris Heidmann; Susann Horn; Stefan Heidmann; Alexander Schleiffer; Kim Nasmyth; Christian F Lehner
The Drosophila meiotic kleisin C(2)M functions before the meiotic divisions.
Chromosoma 2004;113(4):177-87.
2004: Christian H Haering; Doris Schoffnegger; Tatsuya Nishino; Wolfgang Helmhart; Kim Nasmyth; Jan Löwe
Structure and stability of cohesin's Smc1-kleisin interaction.
Molecular cell 2004;15(6):951-64.
2004: Christian G Riedel; Juraj Gregan; Stephan Gruber; Kim Nasmyth
Is chromatin remodeling required to build sister-chromatid cohesion?
Trends in biochemical sciences 2004;29(8):389-92.
2004: Ramzi Azzam; Susan L Chen; Wenying Shou; Angie S Mah; Gabriela Alexandru; Kim Nasmyth; Roland S Annan; Steve Carr; Raymond J Deshaies
Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.
Science (New York, N.Y.) 2004;305(5683):516-9.
2004: Mark Petronczki; Barbara Chwalla; Maria F Siomos; Shihori Yokobayashi; Wolfgang Helmhart; Adam M Deutschbauer; Ronald W Davis; Yoshinori Watanabe; Kim Nasmyth
Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II.
Journal of cell science 2004;117(Pt 16):3547-59.
2004: Kim Nasmyth
Changing places. Interview by Graham Tebb.
Current biology : CB 2004;14(12):R452-3.
2004: Vittorio L Katis; Marta Galova; Kirsten P Rabitsch; Juraj Gregan; Kim Nasmyth
Maintenance of cohesin at centromeres after meiosis I in budding yeast requires a kinetochore-associated protein related to MEI-S332.
Current biology : CB 2004;14(7):560-72.
2004: Hilary Dewar; Kozo Tanaka; Kim Nasmyth; Tomoyuki U Tanaka
Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle.
Nature 2004;428(6978):93-7.
2004: Kirsten P Rabitsch; Juraj Gregan; Alexander Schleiffer; Jean-Paul Javerzat; Frank Eisenhaber; Kim Nasmyth
Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II.
Current biology : CB 2004;14(4):287-301.
2004: Kim Nasmyth; Alexander Schleiffer
From a single double helix to paired double helices and back.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2004;359(1441):99-108.
2004: Karin G Wirth; Romeo Ricci; Juan F Giménez-Abián; Shahryar Taghybeeglu; Nobuaki R Kudo; Wolfram Jochum; Mireille Vasseur-Cognet; Kim Nasmyth
Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation.
Genes & development 2004;18(1):88-98.
2003: Christian H Haering; Kim Nasmyth
Building and breaking bridges between sister chromatids.
BioEssays : news and reviews in molecular, cellular and developmental biology 2003;25(12):1178-91.
2003: Prakash Arumugam; Stephan Gruber; Koichi Tanaka; Christian H Haering; Karl Mechtler; Kim Nasmyth
ATP hydrolysis is required for cohesin's association with chromosomes.
Current biology : CB 2003;13(22):1941-53.
2003: Sara B C Buonomo; Kirsten P Rabitsch; Jörg Fuchs; Stephan Gruber; Matt Sullivan; Frank Uhlmann; Mark Petronczki; Attila Tóth; Kim Nasmyth
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
Developmental cell 2003;4(5):727-39.
2003: Rosemary K Clyne; Vittorio L Katis; Lea Jessop; Kirsten R Benjamin; Ira Herskowitz; Michael Lichten; Kim Nasmyth
Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosis I.
Nature cell biology 2003;5(5):480-5.
2003: Kirsten P Rabitsch; Mark Petronczki; Jean-Paul Javerzat; Sylvie Genier; Barbara Chwalla; Alexander Schleiffer; Tomoyuki U Tanaka; Kim Nasmyth
Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I.
Developmental cell 2003;4(4):535-48.
2003: Stephan Gruber; Christian H Haering; Kim Nasmyth
Chromosomal cohesin forms a ring.
Cell 2003;112(6):765-77.
2003: Alexander Schleiffer; Susanne Kaitna; Sebastian Maurer-Stroh; Michael Glotzer; Kim Nasmyth; Frank Eisenhaber
Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.
Molecular cell 2003;11(3):571-5.
2003: Mark Petronczki; Maria F Siomos; Kim Nasmyth
Un ménage à quatre: the molecular biology of chromosome segregation in meiosis.
Cell 2003;112(4):423-40.
2003: Dmitri M Krylov; Kim Nasmyth; Eugene V Koonin
Evolution of eukaryotic cell cycle regulation: stepwise addition of regulatory kinases and late advent of the CDKs.
Current biology : CB 2003;13(2):173-7.
2002: Kim Nasmyth
Segregating sister genomes: the molecular biology of chromosome separation.
Science (New York, N.Y.) 2002;297(5581):559-65.
2002: Christian H Haering; Jan Löwe; Andreas Hochwagen; Kim Nasmyth
Molecular architecture of SMC proteins and the yeast cohesin complex.
Molecular cell 2002;9(4):773-88.
2002: Dmitri Ivanov; Alexander Schleiffer; Frank Eisenhaber; Karl Mechtler; Christian H Haering; Kim Nasmyth
Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion.
Current biology : CB 2002;12(4):323-8.
2002: Tomoyuki U Tanaka; Najma Rachidi; Carsten Janke; Gislene Pereira; Marta Galova; Elmar Schiebel; Michael J R Stark; Kim Nasmyth
Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections.
Cell 2002;108(3):317-29.
2001: Kim Nasmyth
A prize for proliferation.
Cell 2001;107(6):689-701.
2001: Maria F Siomos; A Badrinath; Pawel Pasierbek; D Livingstone; J White; Michael Glotzer; Kim Nasmyth
Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans.
Current biology : CB 2001;11(23):1825-35.
2001: Gislene Pereira; Tomoyuki U Tanaka; Kim Nasmyth; Elmar Schiebel
Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex.
The EMBO journal 2001;20(22):6359-70.
2001: Kirsten P Rabitsch; Attila Tóth; Marta Gálová; Alexander Schleiffer; G Schaffner; E Aigner; C Rupp; Alexandra Penkner; Alexandra C Moreno-Borchart; Michael Primig; Rochelle Easton Esposito; Franz Klein; Michael Knop; Kim Nasmyth
A screen for genes required for meiosis and spore formation based on whole-genome expression.
Current biology : CB 2001;11(13):1001-9.
2001: C Sjögren; Kim Nasmyth
Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae.
Current biology : CB 2001;11(12):991-5.
2001: MP Cosma; S Panizza; Kim Nasmyth
Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF.
Molecular cell 2001;7(6):1213-20.
2001: Gabriela Alexandru; F Uhlmann; Karl Mechtler; Marc-André Poupart; Kim Nasmyth
Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast.
Cell 2001;105(4):459-72.
2001: Hai Rao; F Uhlmann; Kim Nasmyth; Alexander Varshavsky
Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability.
Nature 2001;410(6831):955-9.
2001: Kim Nasmyth
Disseminating the genome: joining, resolving, and separating sister chromatids during mitosis and meiosis.
Annual review of genetics 2001;35():673-745.
2001: Kim Nasmyth; Jan-Michael Peters; F Uhlmann
Splitting the chromosome: cutting the ties that bind sister chromatids.
Novartis Foundation symposium 2001;237():113-33; discussion 133-8, 158-63.
2000: Attila Tóth; Kirsten P Rabitsch; Marta Gálová; Alexander Schleiffer; Sara B C Buonomo; Kim Nasmyth
Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i.
Cell 2000;103(7):1155-68.
2000: S Panizza; Tomoyuki U Tanaka; Andreas Hochwagen; Frank Eisenhaber; Kim Nasmyth
Pds5 cooperates with cohesin in maintaining sister chromatid cohesion.
Current biology : CB 2000;10(24):1557-64.
2000: Takeshi Tomonaga; Koji Nagao; Y Kawasaki; K Furuya; Akiko Murakami; J Morishita; Tatsuro Yuasa; Takashi Sutani; Stephen E Kearsey; F Uhlmann; Kim Nasmyth; Mitsuhiro Yanagida
Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase.
Genes & development 2000;14(21):2757-70.
2000: Sara B C Buonomo; R K Clyne; Jörg Fuchs; Josef Loidl; Frank Uhlmann; Kim Nasmyth
Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin.
Cell 2000;103(3):387-98.
2000: F Uhlmann; D Wernic; Marc-André Poupart; E V Koonin; Kim Nasmyth
Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast.
Cell 2000;103(3):375-86.
2000: Tomoyuki U Tanaka; Jörg Fuchs; J Loidl; Kim Nasmyth
Cohesin ensures bipolar attachment of microtubules to sister centromeres and resists their precocious separation.
Nature cell biology 2000;2(8):492-9.
2000: Kim Nasmyth; Jan-Michael Peters; F Uhlmann
Splitting the chromosome: cutting the ties that bind sister chromatids.
Science (New York, N.Y.) 2000;288(5470):1379-85.
2000: R Ciosk; M Shirayama; Andrej Shevchenko; T Tanaka; A Toth; A Shevchenko; Kim Nasmyth
Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins.
Molecular cell 2000;5(2):243-54.
1999: M Shirayama; Attila Tóth; Marta Gálová; Kim Nasmyth
APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.
Nature 1999;402(6758):203-7.
1999: T Tanaka; MP Cosma; K Wirth; Kim Nasmyth
Identification of cohesin association sites at centromeres and along chromosome arms.
Cell 1999;98(6):847-58.
1999: Wolfgang Zachariae; Kim Nasmyth
Whose end is destruction: cell division and the anaphase-promoting complex.
Genes & development 1999;13(16):2039-58.
1999: Franz Klein; P Mahr; Marta Galova; Sara B C Buonomo; C Michaelis; K Nairz; Kim Nasmyth
A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis.
Cell 1999;98(1):91-103.
1999: Michael Knop; Katja Siegers; Gislene Pereira; Wolfgang Zachariae; Barbara Winsor; Kim Nasmyth; Elmar Schiebel
Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines.
Yeast (Chichester, England) 1999;15(10B):963-72.
1999: F Uhlmann; F Lottspeich; Kim Nasmyth
Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1.
Nature 1999;400(6739):37-42.
1999: Jae Hong Seol; R M Renny Feldman; Wolfgang Zachariae; Andrej Shevchenko; CC Correll; Svetlana Lyapina; Yong Chi; Marta Galova; J Claypool; S Sandmeyer; Kim Nasmyth; Raymond J Deshaies; A Shevchenko; R J Deshaies
Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34.
Genes & development 1999;13(12):1614-26.
1999: Gabriela Alexandru; Wolfgang Zachariae; Alexander Schleiffer; Kim Nasmyth
Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage.
The EMBO journal 1999;18(10):2707-21.
1999: R Grossberger; Christian Gieffers; Wolfgang Zachariae; Alexandre Podtelejnikov; Alexander Schleiffer; Kim Nasmyth; M Mann; Jan-Michael Peters
Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.
The Journal of biological chemistry 1999;274(20):14500-7.
1999: MP Cosma; T Tanaka; Kim Nasmyth
Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter.
Cell 1999;97(3):299-311.
1999: I Gonzalez; Sara B C Buonomo; Kim Nasmyth; U von Ahsen
ASH1 mRNA localization in yeast involves multiple secondary structural elements and Ash1 protein translation.
Current biology : CB 1999;9(6):337-40.
1999: A Tóth; R Ciosk; F Uhlmann; Marta Galova; Alexander Schleiffer; Kim Nasmyth
Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication.
Genes & development 1999;13(3):320-33.
1998: Wolfgang Zachariae; M Schwab; Kim Nasmyth; W Seufert
Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex.
Science (New York, N.Y.) 1998;282(5394):1721-4.
1998: Frank Uhlmann; Kim Nasmyth
Cohesion between sister chromatids must be established during DNA replication.
Current biology : CB 1998;8(20):1095-101.
1998: T Tanaka; Kim Nasmyth
Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases.
The EMBO journal 1998;17(17):5182-91.
1998: R Ciosk; Wolfgang Zachariae; C Michaelis; Andrej Shevchenko; M Mann; Kim Nasmyth
An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.
Cell 1998;93(6):1067-76.
1998: M Shirayama; Wolfgang Zachariae; R Ciosk; Kim Nasmyth
The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae.
The EMBO journal 1998;17(5):1336-49.
1998: Wolfgang Zachariae; Andrej Shevchenko; Paul D Andrews; R Ciosk; Marta Galova; Michael J R Stark; M Mann; Kim Nasmyth
Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.
Science (New York, N.Y.) 1998;279(5354):1216-9.
1997: C Michaelis; R Ciosk; Kim Nasmyth
Cohesins: chromosomal proteins that prevent premature separation of sister chromatids.
Cell 1997;91(1):35-45.
1997: S Pichler; S Piatti; Kim Nasmyth
Is the yeast anaphase promoting complex needed to prevent re-replication during G2 and M phases?
The EMBO journal 1997;16(19):5988-97.
1997: T Tanaka; D Knapp; Kim Nasmyth
Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs.
Cell 1997;90(4):649-60.
1997: S Irniger; Kim Nasmyth
The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase.
Journal of cell science 1997;110 ( Pt 13)():1523-31.
1997: Kim Nasmyth; R P Jansen
The cytoskeleton in mRNA localization and cell differentiation.
Current opinion in cell biology 1997;9(3):396-400.
1996: Kim Nasmyth
Viewpoint: putting the cell cycle in order.
Science (New York, N.Y.) 1996;274(5293):1643-5.
1996: Wolfgang Zachariae; T H Shin; Marta Galova; B Obermaier; Kim Nasmyth
Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae.
Science (New York, N.Y.) 1996;274(5290):1201-4.
1996: D Knapp; L Bhoite; D J Stillman; Kim Nasmyth
The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1.
Molecular and cellular biology 1996;16(10):5701-7.
1996: Simonetta Piatti; T Böhm; J H Cocker; John F X Diffley; Kim Nasmyth
Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast.
Genes & development 1996;10(12):1516-31.
1996: R F Siegmund; Kim Nasmyth
The Saccharomyces cerevisiae Start-specific transcription factor Swi4 interacts through the ankyrin repeats with the mitotic Clb2/Cdc28 kinase and through its conserved carboxy terminus with Swi6.
Molecular and cellular biology 1996;16(6):2647-55.
1996: Wolfgang Zachariae; Kim Nasmyth
TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast.
Molecular biology of the cell 1996;7(5):791-801.
1996: N Bobola; R P Jansen; T H Shin; Kim Nasmyth
Asymmetric accumulation of Ash1p in postanaphase nuclei depends on a myosin and restricts yeast mating-type switching to mother cells.
Cell 1996;84(5):699-709.
1996: R P Jansen; C Dowzer; C Michaelis; Marta Galova; Kim Nasmyth
Mother cell-specific HO expression in budding yeast depends on the unconventional myosin myo4p and other cytoplasmic proteins.
Cell 1996;84(5):687-97.
1996: C Koch; Alexander Schleiffer; Gustav Ammerer; Kim Nasmyth
Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at start, whereas Clb/Cdc28 kinases displace it from the promoter in G2.
Genes & development 1996;10(2):129-41.
1996: J H Cocker; Simonetta Piatti; C Santocanale; Kim Nasmyth; John F X Diffley
An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast.
Nature 1996;379(6561):180-2.
1995: L Dirick; T Böhm; Kim Nasmyth
Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae.
The EMBO journal 1995;14(19):4803-13.
1995: Kim Nasmyth
Evolution of the cell cycle.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1995;349(1329):271-81.
1995: Simonetta Piatti; Christoph Lengauer; Kim Nasmyth
Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae.
The EMBO journal 1995;14(15):3788-99.
1995: S Irniger; Simonetta Piatti; C Michaelis; Kim Nasmyth
Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast.
Cell 1995;81(2):269-78.
1994: E Schwob; T Böhm; M D Mendenhall; Kim Nasmyth
The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae.
Cell 1994;79(2):233-44.
1994: Angelika Amon; S Irniger; Kim Nasmyth
Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle.
Cell 1994;77(7):1037-50.
1994: C Koch; Kim Nasmyth
Cell cycle regulated transcription in yeast.
Current opinion in cell biology 1994;6(3):451-9.
1993: G Micklem; A Rowley; J Harwood; Kim Nasmyth; John F X Diffley
Yeast origin recognition complex is involved in DNA replication and transcriptional silencing.
Nature 1993;366(6450):87-9.
1993: Angelika Amon; Mike Tyers; Bruce Futcher; Kim Nasmyth
Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins.
Cell 1993;74(6):993-1007.
1993: C Koch; T Moll; M Neuberg; H Ahorn; Kim Nasmyth
A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase.
Science (New York, N.Y.) 1993;261(5128):1551-7.
1993: E Schwob; Kim Nasmyth
CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae.
Genes & development 1993;7(7A):1160-75.
1993: T Moll; E Schwob; C Koch; A Moore; H Auer; Kim Nasmyth
Transcription factors important for starting the cell cycle in yeast.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;340(1293):351-60.
1993: U Surana; Angelika Amon; C Dowzer; J McGrew; Breck E Byers; Kim Nasmyth
Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.
The EMBO journal 1993;12(5):1969-78.
1993: Kim Nasmyth
Control of the yeast cell cycle by the Cdc28 protein kinase.
Current opinion in cell biology 1993;5(2):166-79.
1993: Kim Nasmyth
Regulating the HO endonuclease in yeast.
Current opinion in genetics & development 1993;3(2):286-94.
1993: Beverly Errede; A Gartner; Z Zhou; Kim Nasmyth; Gustav Ammerer
MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro.
Nature 1993;362(6417):261-4.
1993: G Tebb; T Moll; C Dowzer; Kim Nasmyth
SWI5 instability may be necessary but is not sufficient for asymmetric HO expression in yeast.
Genes & development 1993;7(3):517-28.
1992: Michael Primig; S Sockanathan; H Auer; Kim Nasmyth
Anatomy of a transcription factor important for the start of the cell cycle in Saccharomyces cerevisiae.
Nature 1992;358(6387):593-7.
1992: A Gartner; Kim Nasmyth; Gustav Ammerer
Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.
Genes & development 1992;6(7):1280-92.
1992: I Fitch; C Dahmann; U Surana; Angelika Amon; Kim Nasmyth; L Goetsch; Breck E Byers; Bruce Futcher
Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae.
Molecular biology of the cell 1992;3(7):805-18.
1992: L Dirick; T Moll; H Auer; Kim Nasmyth
A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast.
Nature 1992;357(6378):508-13.
1992: Angelika Amon; U Surana; I Muroff; Kim Nasmyth
Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae.
Nature 1992;355(6358):368-71.
1992: T Moll; L Dirick; H Auer; J Bonkovsky; Kim Nasmyth
SWI6 is a regulatory subunit of two different cell cycle START-dependent transcription factors in Saccharomyces cerevisiae.
Journal of cell science. Supplement 1992;16():87-96.
1991: D Lydall; Gustav Ammerer; Kim Nasmyth
A new role for MCM1 in yeast: cell cycle regulation of SW15 transcription.
Genes & development 1991;5(12B):2405-19.
1991: M R Taba; I Muroff; D Lydall; G Tebb; Kim Nasmyth
Changes in a SWI4,6-DNA-binding complex occur at the time of HO gene activation in yeast.
Genes & development 1991;5(11):2000-13.
1991: Kim Nasmyth; L Dirick
The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast.
Cell 1991;66(5):995-1013.
1991: T Moll; G Tebb; U Surana; H Robitsch; Kim Nasmyth
The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5.
Cell 1991;66(4):743-58.
1991: L Dirick; Kim Nasmyth
Positive feedback in the activation of G1 cyclins in yeast.
Nature 1991;351(6329):754-7.
1991: U Surana; H Robitsch; C Price; T Schuster; I Fitch; A B Futcher; Kim Nasmyth
The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae.
Cell 1991;65(1):145-61.
1991: Kim Nasmyth; L Dirick; U Surana; Angelika Amon; F Cvrckova
Some facts and thoughts on cell cycle control in yeast.
Cold Spring Harbor symposia on quantitative biology 1991;56():9-20.
1990: Kim Nasmyth; G Adolf; D Lydall; A Seddon
The identification of a second cell cycle control on the HO promoter in yeast: cell cycle regulation of SW15 nuclear entry.
Cell 1990;62(4):631-47.
1988: Kiyoshi Nagai; Y Nakaseko; Kim Nasmyth; Daniela Rhodes
Zinc-finger motifs expressed in E. coli and folded in vitro direct specific binding to DNA.
Nature 1988;332(6161):284-6.
1987: D Shore; Kim Nasmyth
Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements.
Cell 1987;51(5):721-32.
1987: A H Brand; G Micklem; Kim Nasmyth
A yeast silencer contains sequences that can promote autonomous plasmid replication and transcriptional activation.
Cell 1987;51(5):709-19.
1987: L Breeden; Kim Nasmyth
Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila.
Nature 1987;329(6140):651-4.
1987: D Shore; D J Stillman; A H Brand; Kim Nasmyth
Identification of silencer binding proteins from yeast: possible roles in SIR control and DNA replication.
The EMBO journal 1987;6(2):461-7.