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Giovanni Natile

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Genes & Molecular Sequences

Molecular Structure

Anatomy

Tumor Cell Line

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Phenomena

Procedures

Antitumor Drug Screening Assays

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Co-Publications
Name
19
Intini, Francesco
18
Coluccia, Mauro
16
Brabec, Viktor
13
Boccarelli, Angelina
10
Giordano, Domenico
10
Marzilli, Luigi
9
Margiotta, Nicola
7
Arnesano, Fabio
6
Malina, Jaroslav
5
Sivo, Maria
5
Nováková, Olga
5
Benedetti, Michele
5
Kasparkova, Jana
4
Kaspárková, Jana
4
Fanizzi, Francesco

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Publications

TOP 3
Cornacchia Daniele; Pellicani Raffaella Zoe; Intini Francesco Paolo; Pacifico Concetta; Natile Giovanni
Solution behavior of amidine complexes: an unexpected cis/trans isomerization and formation of di- and trinuclear platinum(III) and platinum(II) species.
Saad Jamil S; Natile Giovanni; Marzilli Luigi G
Origins of the distortions in the base pair step adjacent to platinum anticancer drug-DNA adducts. Fundamental NMR solution studies utilizing right-handed cross-link models having 5'- and 3'-flanking residues.
Banci Lucia; Bertini Ivano; Cantini Francesca; Migliardi Manuele; Natile Giovanni; Nushi Fiorentin; Rosato Antonio
Solution structures of the actuator domain of ATP7A and ATP7B, the Menkes and Wilson disease proteins.

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All Publications

2009: Cornacchia Daniele; Pellicani Raffaella Zoe; Intini Francesco Paolo; Pacifico Concetta; Natile Giovanni
Solution behavior of amidine complexes: an unexpected cis/trans isomerization and formation of di- and trinuclear platinum(III) and platinum(II) species.
Inorganic chemistry 2009;48(22):10800-10.
2009: Saad Jamil S; Natile Giovanni; Marzilli Luigi G
Origins of the distortions in the base pair step adjacent to platinum anticancer drug-DNA adducts. Fundamental NMR solution studies utilizing right-handed cross-link models having 5'- and 3'-flanking residues.
Journal of the American Chemical Society 2009;131(34):12314-24.
2009: Banci Lucia; Bertini Ivano; Cantini Francesca; Migliardi Manuele; Natile Giovanni; Nushi Fiorentin; Rosato Antonio
Solution structures of the actuator domain of ATP7A and ATP7B, the Menkes and Wilson disease proteins.
Biochemistry 2009;48(33):7849-55.
2009: Nováková Olga; Malina Jaroslav; Kaspárková Jana; Halámiková Anna; Bernard Vladan; Intini Francesco; Natile Giovanni; Brabec Viktor
Energetics, conformation, and recognition of DNA duplexes modified by methylated analogues of [PtCl(dien)]+.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(25):6211-21.
2009: Li Chan; Li Zhanyong; Sletten Einar; Arnesano Fabio; Losacco Maurizio; Natile Giovanni; Liu Yangzhong
Methionine can favor DNA platination by trans-coordinated platinum antitumor drugs.
Angewandte Chemie (International ed. in English) 2009;48(45):8497-500.
2009: Arnesano Fabio; Scintilla Simone; Calò Vincenza; Bonfrate Elena; Ingrosso Chiara; Losacco Maurizio; Pellegrino Teresa; Rizzarelli Enrico; Natile Giovanni
Copper-triggered aggregation of ubiquitin.
PloS one 2009;4(9):e7052.
2008: Falini Giuseppe; Fermani Simona; Tosi Giovanna; Arnesano Fabio; Natile Giovanni
Structural probing of Zn(II), Cd(II) and Hg(II) binding to human ubiquitin.
Chemical communications (Cambridge, England) 2008;(45):5960-2.
2008: Margiotta Nicola; Capitelli Francesco; Ostuni Rosa; Natile Giovanni
A new dinuclear platinum complex with a nitrogen-containing geminal bisphosphonate as potential anticancer compound specifically targeted to bone tissues.
Journal of inorganic biochemistry 2008;102(12):2078-86.
2008: Barone Carmen R; Benedetti Michele; Vecchio Vita M; Fanizzi Francesco P; Maresca Luciana; Natile Giovanni
New chemistry of olefin complexes of platinum(II) unravelled by basic conditions: synthesis and properties of elusive cationic species.
Dalton transactions (Cambridge, England : 2003) 2008;(39):5313-22.
2008: Intini Francesco P; Cini Renzo; Tamasi Gabriella; Hursthouse Michael B; Natile Giovanni
NMR and X-ray structural characterization of a cisplatin analogue able to slow down the Pt-N7 rotation of a coordinated guanine base by a billion-fold times: 2,2'-bipiperidine(dimethylmalonato)platinum(II) complex.
Inorganic chemistry 2008;47(11):4909-17.
2008: Halámiková Anna; Heringová Pavla; Kaspárková Jana; Intini Francesco P; Natile Giovanni; Nemirovski Alina; Gibson Dan; Brabec Viktor
Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine.
Journal of inorganic biochemistry 2008;102(5-6):1077-89.
2008: Ranaldo Rosa; Margiotta Nicola; Intini Francesco P; Pacifico Concetta; Natile Giovanni
Conformer distribution in (cis-1,4-DACH)bis(guanosine-5'-phosphate)platinum(II) adducts: a reliable model for DNA adducts of antitumoral cisplatin.
Inorganic chemistry 2008;47(7):2820-30.
2008: de Mier-Vinué Jordi; Gay Marina; Montaña Angel M; Sáez Rosa-Isabel; Moreno Virtudes; Kasparkova Jana; Vrana Oldrich; Heringova Pavla; Brabec Viktor; Boccarelli Angela; Coluccia Mauro; Natile Giovanni
Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands.
Journal of medicinal chemistry 2008;51(3):424-31.
2008: Kasparkova Jana; Vojtiskova Marie; Natile Giovanni; Brabec Viktor
Unique properties of DNA interstrand cross-links of antitumor oxaliplatin and the effect of chirality of the carrier ligand.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(4):1330-41.
2007: Malina Jaroslav; Novakova Olga; Vojtiskova Marie; Natile Giovanni; Brabec Viktor
Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog.
Biophysical journal 2007;93(11):3950-62.
2007: Casini Angela; Gabbiani Chiara; Mastrobuoni Guido; Pellicani Raffaella Zoe; Intini Francesco Paolo; Arnesano Fabio; Natile Giovanni; Moneti Gloriano; Francese Simona; Messori Luigi
Insights into the molecular mechanisms of protein platination from a case study: the reaction of anticancer platinum(II) iminoethers with horse heart cytochrome c.
Biochemistry 2007;46(43):12220-30.
2007: Knipp Markus; Karotki Andrei V; Chesnov Serge; Natile Giovanni; Sadler Peter J; Brabec Viktor; Vasák Milan
Reaction of Zn7metallothionein with cis- and trans-[Pt(N-donor)2Cl2] anticancer complexes: trans-Pt(II) complexes retain their N-donor ligands.
Journal of medicinal chemistry 2007;50(17):4075-86.
2007: Margiotta Nicola; Ostuni Rosa; Teoli Deborah; Morpurgo Margherita; Realdon Nicola; Palazzo Barbara; Natile Giovanni
Bisphosphonate complexation and calcium doping in silica xerogels as a combined strategy for local and controlled release of active platinum antitumor compounds.
Dalton transactions (Cambridge, England : 2003) 2007;(29):3131-9.
2007: Sasanelli Rossella; Boccarelli Angelina; Giordano Domenico; Laforgia Mariarita; Arnesano Fabio; Natile Giovanni; Cardellicchio Cosimo; Capozzi Maria A M; Coluccia Mauro
Platinum complexes can inhibit matrix metalloproteinase activity: platinum-diethyl[(methylsulfinyl)methyl]phosphonate complexes as inhibitors of matrix metalloproteinases 2, 3, 9, and 12.
Journal of medicinal chemistry 2007;50(15):3434-41.
2007: Margiotta Nicola; Ostuni Rosa; Ranaldo Rosa; Denora Nunzio; Laquintana Valentino; Trapani Giuseppe; Liso Gaetano; Natile Giovanni
Synthesis and characterization of a platinum(II) complex tethered to a ligand of the peripheral benzodiazepine receptor.
Journal of medicinal chemistry 2007;50(5):1019-27.
2007: Coluccia Mauro; Natile Giovanni
Trans-platinum complexes in cancer therapy.
Anti-cancer agents in medicinal chemistry 2007;7(1):111-23.
2007: Arnesano Fabio; Scintilla Simone; Natile Giovanni
Interaction between platinum complexes and a methionine motif found in copper transport proteins.
Angewandte Chemie (International ed. in English) 2007;46(47):9062-4.
2007: Milardi Danilo; Arnesano Fabio; Grasso Giulia; Magrì Antonio; Tabbì Giovanni; Scintilla Simone; Natile Giovanni; Rizzarelli Enrico
Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding.
Angewandte Chemie (International ed. in English) 2007;46(42):7993-5.
2007: Benedetti Michele; Tamasi Gabriella; Cini Renzo; Marzilli Luigi G; Natile Giovanni
The first pure LambdaHT rotamer of a complex with a cis-[metal(nucleotide)2] unit: a cis-[Pt(amine)2(nucleotide)2] LambdaHT rotamer with unique molecular structural features.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(11):3131-42.
2006: Margiotta Nicola; Natile Giovanni; Capitelli Francesco; Fanizzi Francesco P; Boccarelli Angelina; De Rinaldis Pietro; Giordano Domenico; Coluccia Mauro
Sterically hindered complexes of platinum(II) with planar heterocyclic nitrogen donors. A novel complex with 1-methyl-cytosine has a spectrum of activity different from cisplatin and is able of overcoming acquired cisplatin resistance.
Journal of inorganic biochemistry 2006;100(11):1849-57.
2006: Kaspárková Jana; Nováková Olga; Vrána Oldrich; Intini Francesco; Natile Giovanni; Brabec Viktor
Molecular aspects of antitumor effects of a new platinum(IV) drug.
Molecular pharmacology 2006;70(5):1708-19.
2006: Pacifico Concetta; Laforgia Mariarita; Intini Francesco P; Padovano Giacomo; Natile Giovanni
Two polymorphs of potassium trichloro[diethyl (methylsulfinylmethyl)phosphonate-kappaS]platinum(II) with Z' = 1 and 3 in the space group P2(1)2(1)2(1).
Acta crystallographica. Section C, Crystal structure communications 2006;62(Pt 7):m306-10.
2006: Boccarelli Angelina; Giordano Domenico; Natile Giovanni; Coluccia Mauro
Differential processing of antitumour-active and antitumour-inactive trans platinum compounds by SKOV-3 ovarian cancer cells.
Biochemical pharmacology 2006;72(3):280-92.
2006: Benedetti Michele; Fanizzi Francesco P; Maresca Luciana; Natile Giovanni
The unexpected reactivity of Zeise's anion in strong basic medium discloses new substitution patterns at the platinum centre.
Chemical communications (Cambridge, England) 2006;(10):1118-20.
2006: Boccarelli Angelina; Intini Francesco P; Sasanelli Rossella; Sivo Maria F; Coluccia Mauro; Natile Giovanni
Synthesis and in vitro antitumor activity of platinum acetonimine complexes.
Journal of medicinal chemistry 2006;49(2):829-37.
2005: Margiotta Nicola; Papadia Paride; Lazzaro Francesco; Crucianelli Marcello; De Angelis Francesco; Pisano Claudio; Vesci Loredana; Natile Giovanni
Platinum-based antitumor drugs containing enantiomerically pure alpha-trifluoromethyl alanine as ligand.
Journal of medicinal chemistry 2005;48(24):7821-8.
2005: Beljanski Vladimir; Villanueva Julie M; Doetsch Paul W; Natile Giovanni; Marzilli Luigi G
Marked dependence on carrier-ligand bulk but not on carrier-ligand chirality of the duplex versus single-strand forms of a DNA oligonucleotide with a series of G-Pt(II)-G intrastrand cross-links modeling cisplatin-DNA adducts.
Journal of the American Chemical Society 2005;127(45):15833-42.
2005: Benedetti Michele; Marzilli Luigi G; Natile Giovanni
Rotamer stability in cis-[Pt(diA)G2] complexes (diA = diamine derivative and G = guanine derivative) mediated by carrier-ligand amine stereochemistry as revealed by circular dichroism spectroscopy.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(18):5302-10.
2005: Papadia Paride; Margiotta Nicola; Bergamo Alberta; Sava Gianni; Natile Giovanni
Platinum(II) complexes with antitumoral/antiviral aromatic heterocycles: effect of glutathione upon in vitro cell growth inhibition.
Journal of medicinal chemistry 2005;48(9):3364-71.
2004: Tamasi Gabriella; Cini Renzo; Intini Francesco P; Sivo Maria F; Natile Giovanni
Unusual reactivity at a platinum center determined by the ligands and the solvent environment.
Angewandte Chemie (International ed. in English) 2004;43(38):5081-4.
2004: Intini Francesco P; Boccarelli Angelina; Francia Valentina C; Pacifico Concetta; Sivo Maria F; Natile Giovanni; Giordano Domenico; De Rinaldis Pietro; Coluccia Mauro
Platinum complexes with imino ethers or cyclic ligands mimicking imino ethers: synthesis, in vitro antitumour activity, and DNA interaction properties.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(6):768-80.
2004: Margiotta Nicola; Bergamo Alberta; Sava Gianni; Padovano Giacomo; de Clercq Erik; Natile Giovanni
Antiviral properties and cytotoxic activity of platinum(II) complexes with 1,10-phenanthrolines and acyclovir or penciclovir.
Journal of inorganic biochemistry 2004;98(8):1385-90.
2004: Sabo Tibor J; Kaluderovic Goran N; Poleti Dejan; Karanovic Ljiljana; Boccarelli Angelina; Cannito Francesco; Natile Giovanni
Cytotoxicity of some platinum(IV) complexes with ethylenediamine-N,N'-di-3-propionato ligand.
Journal of inorganic biochemistry 2004;98(8):1378-84.
2004: Vinje Jo; Intini Francesco P; Natile Giovanni; Sletten Einar
Cytotoxic trans-oriented platinum complexes only form adducts with single-stranded oligodeoxynucleotides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(14):3569-78.
2004: Carlone Maria; Marzilli Luigi G; Natile Giovanni
Platinum complexes with NH groups on the carrier ligand and with only one guanine or hypoxanthine derivative. Informative models for assessing relative nucleobase and nucleotide hydrogen-bond interactions with amine ligands in solution.
Inorganic chemistry 2004;43(2):584-92.
2004: Carlone Maria; Di Masi Nicola G; Maresca Luciana; Margiotta Nicola; Natile Giovanni
Role of metal ions and hydrogen bond acceptors in the tautomeric equilibrium of nitro-9[(alkylamino)amino]-acridine drugs.
Bioinorganic chemistry and applications 2004;():93-104.
2004: Natile Giovanni; Coluccia Mauro
Antitumor active trans-platinum compounds.
Metal ions in biological systems 2004;42():209-50.
2003: Benedetti Michele; Tamasi Gabriella; Cini Renzo; Natile Giovanni
X-ray structure and circular dichroism of pure rotamers of bis[guanosine-5'-monophosphate(-1)](N,N,N',N'-tetramethylcyclohexyl-1,2-diamine)platinum(II) complexes that have R,R and S,S configurations at the asymmetric diamine.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(24):6122-32.
2003: Novakova Olga; Kasparkova Jana; Malina Jaroslav; Natile Giovanni; Brabec Viktor
DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes.
Nucleic acids research 2003;31(22):6450-60.
2003: Colonna Gianpiero; Di Masi Nicola G; Marzilli Luigi G; Natile Giovanni
Ground-state stability and rotational activation parameters for individual rotamers of (R,S,S,R)-(N,N'-dimethyl-2,3-diaminobutane)PtG(2) complexes (G = 9-EtG, 3'-GMP, and 5'-GMP).
Inorganic chemistry 2003;42(4):997-1005.
2002: Benedetti Michele; Malina Jaroslav; Kasparkova Jana; Brabec Viktor; Natile Giovanni
Chiral discrimination in platinum anticancer drugs.
Environmental health perspectives 2002;110 Suppl 5():779-82.
2002: Liu Yangzhong; Vinje Jo; Pacifico Concetta; Natile Giovanni; Sletten Einar
Formation of adenine-N3/guanine-N7 cross-link in the reaction of trans-oriented platinum substrates with dinucleotides.
Journal of the American Chemical Society 2002;124(43):12854-62.
2002: Saad Jamil S; Scarcia Tommaso; Natile Giovanni; Marzilli Luigi G
Factors influencing conformer equilibria in retro models of cisplatin-DNA adducts as revealed by moderately dynamic (N,N'-dimethyl-2,3-diaminobutane)PtG(2) retro models (G = a guanine derivative).
Inorganic chemistry 2002;41(19):4923-35.
2002: Janovská Eva; Nováková Olga; Natile Giovanni; Brabec Viktor
Differential genotoxic effects of antitumor trans-[PtCl(2)(E-iminoether)(2)] and cisplatin in Escherichia coli.
Journal of inorganic biochemistry 2002;90(3-4):155-8.
2002: Malina Jaroslav; Kasparkova Jana; Natile Giovanni; Brabec Viktor
Recognition of major DNA adducts of enantiomeric cisplatin analogs by HMG box proteins and nucleotide excision repair of these adducts.
Chemistry & biology 2002;9(5):629-38.
2002: Bokach Nadezhda A; Kukushkin Vadim Yu; Kuznetsov Maxim L; Garnovskii Dmitrii A; Natile Giovanni; Pombeiro Armando J L
Direct addition of alcohols to organonitriles activated by ligation to a platinum(IV) center.
Inorganic chemistry 2002;41(8):2041-53.
2002: Saad Jamil S; Scarcia Tommaso; Shinozuka Kazuo; Natile Giovanni; Marzilli Luigi G
Modification of second-sphere communication, leading to an unusually high abundance of the head-to-head conformer of cisplatin cross-link retro models.
Inorganic chemistry 2002;41(3):546-57.
2002: Gonzalez Ana M; Cini Renzo; Intini Francesco P; Pacifico Concetta; Natile Giovanni
X-ray structures of the first platinum complexes with Z configuration iminoether ligands: trans-dichlorobis(1-imino-1-methoxy-2,2'-dimethylpropane)platinum(II) and trans-tetrachlorobis(1-imino-1-methoxy-2,2'-dimethylpropane)platinum(IV).
Inorganic chemistry 2002;41(3):470-8.
2001: Williams K M; Scarcia T; Natile G; Marzilli L G
Imprinting structural information from a GpG ligand into the configuration of a chiral diamine ligand through second-sphere communication in platinum(II) complexes.
Inorganic chemistry 2001;40(3):445-54.
2000: Leng M; Locker D; Giraud-Panis M J; Schwartz A; Intini F P; Natile G; Pisano C; Boccarelli A; Giordano D; Coluccia M
Replacement of an NH(3) by an iminoether in transplatin makes an antitumor drug from an inactive compound.
Molecular pharmacology 2000;58(6):1525-35.
2000: Malina J; Hofr C; Maresca L; Natile G; Brabec V
DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands.
Biophysical journal 2000;78(4):2008-21.
2000: Carlone M; Fanizzi F P; Intini F P; Margiotta N; Marzilli L G; Natile G
Influence of carrier ligand NH hydrogen bonding to the O6 and phosphate group of guanine nucleotides in platinum complexes with a single guanine ligand.
Inorganic chemistry 2000;39(4):634-41.
2000: Liu Y; Sivo M F; Natile G; Sletten E
Antitumor Trans Platinum Adducts of GMP and AMP.
Metal-based drugs 2000;7(4):169-76.
2000: Andersen B; Margiotta N; Coluccia M; Natile G; Sletten E
Antitumor Trans Platinum DNA Adducts: NMR and HPLC Study of the Interaction Between a trans-Pt Iminoether Complex and the Deoxy Decamer d(CCTCGCTCTC).d(GAGAGCGAGG).
Metal-based drugs 2000;7(1):23-32.
1999: Coluccia M; Nassi A; Boccarelli A; Giordano D; Cardellicchio N; Intini F P; Natile G; Barletta A; Paradiso A
In vitro antitumour activity and cellular pharmacological properties of the platinum-iminoether complex trans-[PtCl2[E-HN=C(OMe)Me]2].
International journal of oncology 1999;15(5):1039-44.
1999: Coluccia M; Nassi A; Boccarelli A; Giordano D; Cardellicchio N; Locker D; Leng M; Sivo M; Intini F P; Natile G
In vitro and in vivo antitumour activity and cellular pharmacological properties of new platinum-iminoether complexes with different configuration at the iminoether ligands.
Journal of inorganic biochemistry 1999;77(1-2):31-5.
1999: Boccarelli A; Coluccia M; Intini F P; Natile G; Locker D; Leng M
Cytotoxicity and DNA binding mode of new platinum-iminoether derivatives with different configuration at the iminoether ligands.
Anti-cancer drug design 1999;14(3):253-64.
1998: Balcarová Z; Kaspárková J; Zákovská A; Nováková O; Sivo M F; Natile G; Brabec V
DNA interactions of a novel platinum drug, cis-[PtCl(NH3)2(N7-acyclovir)]+.
Molecular pharmacology 1998;53(5):846-55.
1997: Zaludová R; Zákovská A; Kaspárkova J; Balcarová Z; Vrána O; Coluccia M; Natile G; Brabec V
DNA modifications by antitumor trans-[PtCl2(E-iminoether)2].
Molecular pharmacology 1997;52(3):354-61.
1997: Zaludová R; Natile G; Brabec V
The effect of antitumor trans-[PtCl2(E-iminoether)2] on B-->Z transition in DNA.
Anti-cancer drug design 1997;12(4):295-309.
1996: Brabec V; Vrána O; Nováková O; Kleinwächter V; Intini F P; Coluccia M; Natile G
DNA adducts of antitumor trans-[PtCl2 (E-imino ether)2].
Nucleic acids research 1996;24(2):336-41.
1995: Coluccia M; Boccarelli A; Mariggiò M A; Cardellicchio N; Caputo P; Intini F P; Natile G
Platinum(II) complexes containing iminoethers: a trans platinum antitumour agent.
Chemico-biological interactions 1995;98(3):251-66.
1993: Coluccia M; Nassi A; Loseto F; Boccarelli A; Mariggio M A; Giordano D; Intini F P; Caputo P; Natile G
A trans-platinum complex showing higher antitumor activity than the cis congeners.
Journal of medicinal chemistry 1993;36(4):510-2.
1991: Coluccia M; Fanizzi F P; Giannini G; Giordano D; Intini F P; Lacidogna G; Loseto F; Mariggio M A; Nassi A; Natile G
Synthesis, mutagenicity, binding to pBR 322 DNA and antitumour activity of platinum(II) complexes with ethambutol.
Anticancer research 1991;11(1):281-7.
1989: Coluccia M; Giordano D; Loseto F; Intini F P; Maresca L; Natile G
Different binding to DNA of enantiomeric platinum complexes assessed by inhibition of restriction enzyme activity.
Anticancer research 1989;9(3):795-8.

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