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Heinz Nau

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Diana Ivanova; Hinrich Gronemeyer; Pablo Steinberg; Heinz Nau
Enantioselective apoptosis induction in histiocytic lymphoma cells and acute promyelocytic leukemia cells.
Kamil Gotfryd; Maria Hansen; Anna Christensen; Heinz Nau; Vladimir Berezin; Elisabeth Bock; U Ellerbeck; Peter S Walmod
The teratogenic potencies of valproic acid derivatives and their effects on biological end-points are related to changes in histone deacetylase and Erk1/2 activities.
Christian Riebeling; Ralph Pirow; Klaus Becker; Roland Buesen; Daniel Eikel; Johanna Kaltenhäuser; Frauke Meyer; Heinz Nau; Birgitta Slawik; Anke Visan; Jutta Volland; Horst Spielmann; Andreas Luch; Andrea Seiler
The embryonic stem cell test as tool to assess structure-dependent teratogenicity: the case of valproic acid.

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All Publications

2013: Diana Ivanova; Hinrich Gronemeyer; Pablo Steinberg; Heinz Nau
Enantioselective apoptosis induction in histiocytic lymphoma cells and acute promyelocytic leukemia cells.
Archives of toxicology 2013;87(2):303-10.
2011: Kamil Gotfryd; Maria Hansen; Anna Christensen; Heinz Nau; Vladimir Berezin; Elisabeth Bock; U Ellerbeck; Peter S Walmod
The teratogenic potencies of valproic acid derivatives and their effects on biological end-points are related to changes in histone deacetylase and Erk1/2 activities.
Basic & clinical pharmacology & toxicology 2011;109(3):164-74.
2011: Christian Riebeling; Ralph Pirow; Klaus Becker; Roland Buesen; Daniel Eikel; Johanna Kaltenhäuser; Frauke Meyer; Heinz Nau; Birgitta Slawik; Anke Visan; Jutta Volland; Horst Spielmann; Andreas Luch; Andrea Seiler
The embryonic stem cell test as tool to assess structure-dependent teratogenicity: the case of valproic acid.
Toxicological sciences : an official journal of the Society of Toxicology 2011;120(2):360-70.
2010: Michael Hettwer; Marcos A Reis-Fernandes; Marcus Iken; Michael Ott; Pablo Steinberg; Heinz Nau
Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing.
Reproductive toxicology (Elmsford, N.Y.) 2010;30(1):113-20.
2009: Jan P Schuchardt; David Wahlström; Joëlle Rüegg; Norbert Giese; Madalina Stefan; Henning Hopf; Ingemar Pongratz; Helen Håkansson; Gregor Eichele; Katarina Pettersson; Heinz Nau
The endogenous retinoid metabolite S-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo.
The FEBS journal 2009;276(11):3043-59.
2008: Ute Gravemann; Jutta Volland; Heinz Nau
Hydroxamic acid and fluorinated derivatives of valproic acid: anticonvulsant activity, neurotoxicity and teratogenicity.
Neurotoxicology and teratology 2008;30(5):390-4.
2007: Sasithorn Limsuwan; Beate Priess; Natthasit Tansakul; Heinz Nau; Manfred Kietzmann; Gerd Hamscher
Penetration studies of propoxur and phoxim from eggshell into whole egg after experimental exposure and application in henhouses.
Journal of agricultural and food chemistry 2007;55(15):6401-5.
2007: Gerd Hamscher; Beate Priess; Heinz Nau
Determination of phoxim residues in eggs by using high-performance liquid chromatography diode array detection after treatment of stocked housing facilities for the poultry red mite (Dermanyssus gallinae).
Analytica chimica acta 2007;586(1-2):330-5.
2007: Kamil Gotfryd; Sylwia Owczarek; Katrin Hoffmann; Boris Klementiev; Heinz Nau; Vladimir Berezin; Elisabeth Bock; Peter S Walmod
Multiple effects of pentyl-4-yn-VPA enantiomers: from toxicity to short-term memory enhancement.
Neuropharmacology 2007;52(3):764-78.
2006: Hedwig Deubzer; Barbara Busche; Gabi Rönndahl; Daniel Eikel; Martin Michaelis; Jindrich Cinatl; Sandra Schulze; Heinz Nau; Olaf Witt
Novel valproic acid derivatives with potent differentiation-inducing activity in myeloid leukemia cells.
Leukemia research 2006;30(9):1167-75.
2006: Heinz Nau
[Impacts and impact mechanisms of "dioxins" in humans and animals].
DTW. Deutsche tierärztliche Wochenschrift 2006;113(8):292-7.
2006: Norbert B Ghyselinck; Nadege vernet; Christine Dennefeld; Norbert Giese; Heinz Nau; Pierre Chambon; Stéphane Viville; Manuel Mark
Retinoids and spermatogenesis: lessons from mutant mice lacking the plasma retinol binding protein.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(6):1608-22.
2006: Daniel Eikel; Katrin Hoffmann; Karolin Zoll; Alfonso Lampen; Heinz Nau
S-2-pentyl-4-pentynoic hydroxamic acid and its metabolite s-2-pentyl-4-pentynoic acid in the NMRI-exencephaly-mouse model: pharmacokinetic profiles, teratogenic effects, and histone deacetylase inhibition abilities of further valproic acid hydroxamates and amides.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(4):612-20.
2006: Martin Michaelis; Tatyana Suhan; U Ruth Michaelis; K Beek; Florian Rothweiler; Lars Tausch; Oliver Werz; Daniel Eikel; M Zörnig; Heinz Nau; Ingrid Fleming; Hans Wilhelm Doerr; Jindrich Cinatl
Valproic acid induces extracellular signal-regulated kinase 1/2 activation and inhibits apoptosis in endothelial cells.
Cell death and differentiation 2006;13(3):446-53.
2006: Daniel Eikel; Alfonso Lampen; Heinz Nau
Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives.
Chemical research in toxicology 2006;19(2):272-8.
2005: Pi Hoegberg; Carsten K Schmidt; Nick Fletcher; Charlotte B Nilsson; Christina Trossvik; A Gerlienke Schuur; Abraham Brouwer; Heinz Nau; Norbert B Ghyselinck; Pierre Chambon; Helen Håkansson
Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms.
Chemico-biological interactions 2005;156(1):25-39.
2005: Martin Michaelis; Tatyana Suhan; Alexander Reinisch; Agnes Reisenauer; Corinna Fleckenstein; Daniel Eikel; Hermann Gümbel; Hans Wilhelm Doerr; Heinz Nau; Jindrich Cinatl
Increased replication of human cytomegalovirus in retinal pigment epithelial cells by valproic acid depends on histone deacetylase inhibition.
Investigative ophthalmology & visual science 2005;46(9):3451-7.
2005: Nick Fletcher; Norbert Giese; Carsten Schmidt; Natalia Stern; P Monica Lind; Matti Viluksela; Jouni T Tuomisto; Jouko Tuomisto; Heinz Nau; Helen Håkansson
Altered retinoid metabolism in female Long-Evans and Han/Wistar rats following long-term 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treatment.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):264-72.
2005: Alfonso Lampen; Paul A Grimaldi; Heinz Nau
Modulation of peroxisome proliferator-activated receptor delta activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation.
Molecular pharmacology 2005;68(1):193-203.
2005: Alfonso Lampen; M Leifheit; J Voss; Heinz Nau
Molecular and cellular effects of cis-9, trans-11-conjugated linoleic acid in enterocytes: effects on proliferation, differentiation, and gene expression.
Biochimica et biophysica acta 2005;1735(1):30-40.
2005: Nicolas Matt; Carsten K Schmidt; Valérie Dupé; Christine Dennefeld; Heinz Nau; Pierre Chambon; Manuel Mark; Norbert B Ghyselinck
Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;233(1):167-76.
2005: Britta J Eickholt; Greg J Towers; W Jonathan Ryves; Daniel Eikel; K Adley; Laura M J Ylinen; Neil H Chadborn; Adrian J Harwood; Heinz Nau; Robin S B Williams
Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3beta inhibition, and viral replication: a screening approach for new bipolar disorder drugs derived from the valproic acid core structure.
Molecular pharmacology 2005;67(5):1426-33.
2005: Gerd Hamscher; Beate Priess; Heinz Nau; Edmond Panariti
Determination of colchicine residues in sheep serum and milk using high-performance liquid chromatography combined with electrospray ionization ion trap tandem mass spectrometry.
Analytical chemistry 2005;77(8):2421-5.
2005: Gerd Hamscher; Heike Theresia Pawelzick; Heinrich Höper; Heinz Nau
Different behavior of tetracyclines and sulfonamides in sandy soils after repeated fertilization with liquid manure.
Environmental toxicology and chemistry / SETAC 2005;24(4):861-8.
2005: Ralph Rühl; Gerd Hamscher; Ada L Garcia; Heinz Nau; Florian Schweigert
Identification of 14-hydroxy-retro-retinol and 4-hydroxy-retinol as endogenous retinoids in rats throughout neonatal development.
Life sciences 2005;76(14):1613-22.
2004: Steffen Baltes; Heinz Nau; Alfonso Lampen
All-trans retinoic acid enhances differentiation and influences permeability of intestinal Caco-2 cells under serum-free conditions.
Development, growth & differentiation 2004;46(6):503-14.
2004: Mohamed Elmazar or El-Mazar; Heinz Nau
Potentiation of the teratogenic effects induced by coadministration of retinoic acid or phytanic acid/phytol with synthetic retinoid receptor ligands.
Archives of toxicology 2004;78(11):660-8.
2004: Martin Michaelis; Nezira Köhler; Alexander Reinisch; Daniel Eikel; Ute Gravemann; Hans Wilhelm Doerr; Heinz Nau; Jindrich Cinatl
Increased human cytomegalovirus replication in fibroblasts after treatment with therapeutical plasma concentrations of valproic acid.
Biochemical pharmacology 2004;68(3):531-8.
2004: Peter S Walmod; Ute Gravemann; Heinz Nau; Vladimir Berezin; Elisabeth Bock
Discriminative power of an assay for automated in vitro screening of teratogens.
Toxicology in vitro : an international journal published in association with BIBRA 2004;18(4):511-25.
2004: Heinz Nau
[Safety of food products updated in perspective--an introduction to the following scientific articles].
DTW. Deutsche tierärztliche Wochenschrift 2004;111(7):272.
2004: Martin Michaelis; U Ruth Michaelis; Ingrid Fleming; Tatyana Suhan; Jindrich Cinatl; Roman A Blaheta; Katrin Hoffmann; Rouslan Kotchetkov; Rudi Busse; Heinz Nau; Jindrich Cinatl
Valproic acid inhibits angiogenesis in vitro and in vivo.
Molecular pharmacology 2004;65(3):520-7.
2003: Jesús Santos-Guzmán; Thomas Arnhold; Heinz Nau; Conrad Wagner; Sharon H Fahr; Gloria E Mao; Marie A Caudill; Jennie C Wang; Susanne M Henning; Marian E Swendseid; Michael D Collins
Antagonism of hypervitaminosis A-induced anterior neural tube closure defects with a methyl-donor deficiency in murine whole-embryo culture.
The Journal of nutrition 2003;133(11):3561-70.
2003: Gerd Hamscher; Heike Theresia Pawelzick; Silke Sczesny; Heinz Nau; Jörg Hartung
Antibiotics in dust originating from a pig-fattening farm: a new source of health hazard for farmers?
Environmental health perspectives 2003;111(13):1590-4.
2003: Gerd Hamscher; Heinz Nau
[Effects of animal housing facilities on residues and contaminants in food].
DTW. Deutsche tierärztliche Wochenschrift 2003;110(8):316-9.
2003: Carsten K Schmidt; Pi Hoegberg; Nick Fletcher; Charlotte B Nilsson; Christina Trossvik; Helen Håkansson; Heinz Nau
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the endogenous metabolism of all-trans-retinoic acid in the rat.
Archives of toxicology 2003;77(7):371-83.
2003: Carsten K Schmidt; Abraham Brouwer; Heinz Nau
Chromatographic analysis of endogenous retinoids in tissues and serum.
Analytical biochemistry 2003;315(1):36-48.
2003: Alfonso Lampen; Susan Zimnik; Heinz Nau
Teratogenic phthalate esters and metabolites activate the nuclear receptors PPARs and induce differentiation of F9 cells.
Toxicology and applied pharmacology 2003;188(1):14-23.
2003: Pi Hoegberg; Carsten K Schmidt; Heinz Nau; A Catharine Ross; Reza Zolfaghari; Nick Fletcher; Christina Trossvik; Charlotte B Nilsson; Helen Håkansson
2,3,7,8-tetrachlorodibenzo-p-dioxin induces lecithin: retinol acyltransferase transcription in the rat kidney.
Chemico-biological interactions 2003;145(1):1-16.
2003: Silke Sczesny; Heinz Nau; Gerd Hamscher
Residue analysis of tetracyclines and their metabolites in eggs and in the environment by HPLC coupled with a microbiological assay and tandem mass spectrometry.
Journal of agricultural and food chemistry 2003;51(3):697-703.
2003: Roland Buesen; Melissa Mock; Heinz Nau; Albrecht Seidel; Jürgen Jacob; Alfonso Lampen
Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites.
Chemico-biological interactions 2003;142(3):201-21.
2002: Roman A Blaheta; Heinz Nau; Martin Michaelis; Jindrich Cinatl
Valproate and valproate-analogues: potent tools to fight against cancer.
Current medicinal chemistry 2002;9(15):1417-33.
2002: Patrick Sauvant; Vincent Sapin; Armand Abergel; Carsten K Schmidt; Loïc Blanchon; Marie-Cécile Alexandre-Gouabau; Jean Rosenbaum; Gilles Bommelaer; Edmond Rock; Bernard Dastugue; Heinz Nau; Véronique Azaïs-Braesco
PAV-1, a new rat hepatic stellate cell line converts retinol into retinoic acid, a process altered by ethanol.
The international journal of biochemistry & cell biology 2002;34(8):1017-29.
2002: Carsten K Schmidt; Jutta Volland; Gerd Hamscher; Heinz Nau
Characterization of a new endogenous vitamin A metabolite.
Biochimica et biophysica acta 2002;1583(2):237-51.
2002: Florian Schweigert; Christiane Siegling; Georg Tzimas; Johannes Seeger; Heinz Nau
Distribution of endogenous retinoids, retinoid binding proteins (RBP, CRABPI) and nuclear retinoid X receptor beta (RXRbeta) in the porcine embryo.
Reproduction, nutrition, development 2002;42(4):285-94.
2002: Peter S Walmod; Anton Berezin; Helen C Gallagher; Ute Gravemann; Eugene A Lepekhin; Vadym Belman; Christopher L Bacon; Heinz Nau; Ciaran M Regan; Vladimir Berezin; Elisabeth Bock
Automated in vitro screening of teratogens.
Toxicology and applied pharmacology 2002;181(1):1-15.
2002: Gerd Hamscher; Silke Sczesny; Heinrich Höper; Heinz Nau
Determination of persistent tetracycline residues in soil fertilized with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.
Analytical chemistry 2002;74(7):1509-18.
2002: Thomas Arnhold; Mohamed Elmazar or El-Mazar; Heinz Nau
Prevention of vitamin A teratogenesis by phytol or phytanic acid results from reduced metabolism of retinol to the teratogenic metabolite, all-trans-retinoic acid.
Toxicological sciences : an official journal of the Society of Toxicology 2002;66(2):274-82.
2002: Thomas Arnhold; Heinz Nau; Silke Meyer; Hermann J Rothkoetter; Alfonso Lampen
Porcine intestinal metabolism of excess vitamin a differs following vitamin a supplementation and liver consumption.
The Journal of nutrition 2002;132(2):197-203.
2001: Alfonso Lampen; Carsten Carlberg; Heinz Nau
Peroxisome proliferator-activated receptor delta is a specific sensor for teratogenic valproic acid derivatives.
European journal of pharmacology 2001;431(1):25-33.
2001: Heinz Nau
Teratogenicity of isotretinoin revisited: species variation and the role of all-trans-retinoic acid.
Journal of the American Academy of Dermatology 2001;45(5):S183-7.
2001: Alfonso Lampen; S Meyer; Heinz Nau
Phytanic acid and docosahexaenoic acid increase the metabolism of all-trans-retinoic acid and CYP26 gene expression in intestinal cells.
Biochimica et biophysica acta 2001;1521(1-3):97-106.
2001: Ralph Rühl; JO Sass; Heinz Nau; S Klug
Effects of all-trans-retinoic acid and all-trans-retinoyl glucuronide in two in vitro systems of distinct biological complexity.
Archives of toxicology 2001;75(8):497-504.
2001: Ralph Rühl; Claudia Plum; Mohamed Elmazar or El-Mazar; Heinz Nau
Embryonic subcellular distribution of 13-cis- and all-trans-retinoic acid indicates differential cytosolic/nuclear localization.
Toxicological sciences : an official journal of the Society of Toxicology 2001;63(1):82-9.
2001: Keith J Murphy; GB Fox; Andrew G Foley; Helen C Gallagher; Alan W O'connell; A M Griffin; Heinz Nau; Ciaran M Regan
Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning, and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobe.
Journal of neurochemistry 2001;78(4):704-14.
2001: Ralph Rühl; R Thiel; T S Lacker; S Strohschein; Klaus Albert; Heinz Nau
Synthesis, high-performance liquid chromatography-nuclear magnetic resonance characterization and pharmacokinetics in mice of CD271 glucuronide.
Journal of chromatography. B, Biomedical sciences and applications 2001;757(1):101-9.
2001: Uwe Werling; S Siehler; Margarethe Litfin; Heinz Nau; Martin Göttlicher
Induction of differentiation in F9 cells and activation of peroxisome proliferator-activated receptor delta by valproic acid and its teratogenic derivatives.
Molecular pharmacology 2001;59(5):1269-76.
2001: Alfonso Lampen; S Meyer; Heinz Nau
Effects of receptor-selective retinoids on CYP26 gene expression and metabolism of all-trans-retinoic acid in intestinal cells.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(5):742-7.
2001: Alfonso Lampen; Martin Göttlicher; Heinz Nau
Prediction of embryotoxic effects of valproic acid-derivatives with molecular in vitro methods.
ALTEX 2001;18(2):123-6.
2001: Mohamed Elmazar or El-Mazar; Ralph Rühl; Heinz Nau
Synergistic teratogenic effects induced by retinoids in mice by coadministration of a RARalpha- or RARgamma-selective agonist with a RXR-selective agonist.
Toxicology and applied pharmacology 2001;170(1):2-9.
2000: W C Chen; JO Sass; Holger Seltmann; Heinz Nau; Constantin E Orfanos; Christos Zouboulis
Biological effects and metabolism of 9-cis-retinoic acid and its metabolite 9,13-di-cis-retinoic acid in HaCaT keratinocytes in vitro: comparison with all-trans-retinoic acid.
Archives of dermatological research 2000;292(12):612-20.
2000: Charlotte B Nilsson; Pi Hoegberg; Christina Trossvik; Véronique Azaïs-Braesco; William S Blaner; G Fex; Earl H Harrison; Heinz Nau; Carsten K Schmidt; AM Van Bennekum; Helen Håkansson
2,3,7,8-tetrachlorodibenzo-p-dioxin increases serum and kidney retinoic acid levels and kidney retinol esterification in the rat.
Toxicology and applied pharmacology 2000;169(2):121-31.
2000: Alfonso Lampen; S Meyer; Thomas Arnhold; Heinz Nau
Metabolism of vitamin A and its active metabolite all-trans-retinoic acid in small intestinal enterocytes.
The Journal of pharmacology and experimental therapeutics 2000;295(3):979-85.
2000: Gerd Hamscher; Silke Sczesny; A Abu-Qare; Heinrich Höper; Heinz Nau
[Substances with pharmacological effects including hormonally active substances in the environment: identification of tetracyclines in soil fertilized with animal slurry].
DTW. Deutsche tierärztliche Wochenschrift 2000;107(8):332-4.
2000: Hossam M M Arafa; Mohamed Elmazar or El-Mazar; F M Hamada; Uwe Reichert; B Shroot; Heinz Nau
Selective agonists of retinoic acid receptors: comparative toxicokinetics and embryonic exposure.
Archives of toxicology 2000;73(10-11):547-56.
1999: Alfonso Lampen; S Siehler; U Ellerbeck; Martin Göttlicher; Heinz Nau
New molecular bioassays for the estimation of the teratogenic potency of valproic acid derivatives in vitro: activation of the peroxisomal proliferator-activated receptor (PPARdelta).
Toxicology and applied pharmacology 1999;160(3):238-49.
1999: Liliane Didierjean; JO Sass; Pierre Carraux; Denise Grand; Olivier Sorg; Claudia Plum; Heinz Nau; Jean-Hilaire Saurat
Topical 9-cis-retinaldehyde for delivery of 9-cis-retinoic acid in mouse skin.
Experimental dermatology 1999;8(3):199-203.
1999: JO Sass; G Tzimas; Mohamed Elmazar or El-Mazar; Heinz Nau
Metabolism of retinaldehyde isomers in pregnant rats: 13-cis- and all-trans-retinaldehyde, but not 9-cis-retinaldehyde, yield very similar patterns of retinoid metabolites.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(3):317-21.
1999: Christos Zouboulis; Holger Seltmann; JO Sass; Ralph Rühl; Claudia Plum; U Hettmannsperger; Ulrike Blume-Peytavi; Heinz Nau; Constantin E Orfanos
Retinoid signaling by all-trans retinoic acid and all-trans retinoyl-beta-D-glucuronide is attenuated by simultaneous exposure of human keratinocytes to retinol.
The Journal of investigative dermatology 1999;112(2):157-64.
1998: U Bojic; K Ehlers; U Ellerbeck; C L Bacon; E O'Driscoll; C O'Connell; Vladimir Berezin; Anna Christensen; Eugene A Lepekhin; Elisabeth Bock; Ciaran M Regan; Heinz Nau
Studies on the teratogen pharmacophore of valproic acid analogues: evidence of interactions at a hydrophobic centre.
European journal of pharmacology 1998;354(2-3):289-99.
1998: J Tillner; Heinz Nau; Thomas Winckler; Theo Dingermann
Evaluation of the Teratogenic Potential of Valproic Acid Analogues in Transgenic Dictyostelium discoideum Strains.
Toxicology in vitro : an international journal published in association with BIBRA 1998;12(4):463-9.
1998: C L Bacon; Vladimir Berezin; G Bode; Elisabeth Bock; U Bojic; P Doherty; K Ehlers; U Ellerbeck; P Julien; A Kawa; T E Maar; Heinz Nau; R Pirovano; Ciaran M Regan; A Schousboe; F Spezia; F S Walsh; E J Williams
Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: Application to valproic acid and related analogues of varying potency.
Toxicology in vitro : an international journal published in association with BIBRA 1998;12(2):101-9.
1998: M Radatz; K Ehlers; Boris Yagen; M Bialer; Heinz Nau
Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acid.
Epilepsy research 1998;30(1):41-8.
1998: R Hishida; Heinz Nau
VPA-induced neural tube defects in mice. I. Altered metabolism of sulfur amino acids and glutathione.
Teratogenesis, carcinogenesis, and mutagenesis 1998;18(2):49-61.
1998: Peter S Walmod; A Foley; Anton Berezin; U Ellerbeck; Heinz Nau; Elisabeth Bock; Vladimir Berezin
Cell motility is inhibited by the antiepileptic compound, valproic acid and its teratogenic analogues.
Cell motility and the cytoskeleton 1998;40(3):220-37.
1998: Christos Zouboulis; L Xia; H Akamatsu; Holger Seltmann; M Fritsch; S Hornemann; Ralph Rühl; WenChieh Chen; Heinz Nau; Constantin E Orfanos
The human sebocyte culture model provides new insights into development and management of seborrhoea and acne.
Dermatology (Basel, Switzerland) 1998;196(1):21-31.
1997: JO Sass; G Tzimas; Heinz Nau
9,13-Dicis-retinoic acid as an isomerization product of 9-cis-retinoic acid.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(12):1447-8.
1997: Mohamed Elmazar or El-Mazar; Ralph Rühl; Uwe Reichert; B Shroot; Heinz Nau
RARalpha-mediated teratogenicity in mice is potentiated by an RXR agonist and reduced by an RAR antagonist: dissection of retinoid receptor-induced pathways.
Toxicology and applied pharmacology 1997;146(1):21-8.
1997: G Tzimas; R Thiel; Ibrahim Chahoud; Heinz Nau
The area under the concentration-time curve of all-trans-retinoic acid is the most suitable pharmacokinetic correlate to the embryotoxicity of this retinoid in the rat.
Toxicology and applied pharmacology 1997;143(2):436-44.
1997: TE Maar; U Ellerbeck; Elisabeth Bock; Heinz Nau; Arne Schousboe; Vladimir Berezin
Prediction of teratogenic potency of valproate analogues using cerebellar aggregation cultures.
Toxicology 1997;116(1-3):159-68.
1997: JO Sass; B Zimmermann; Ralph Rühl; Heinz Nau
Effects of all-trans-retinoyl-beta-D-glucuronide and all-trans-retinoic acid on chondrogenesis and retinoid metabolism in mouse limb bud mesenchymal cells in vitro.
Archives of toxicology 1997;71(3):142-50.
1996: G Tzimas; Heinz Nau; Andrew G Hendrickx; Pamela E Peterson; H Hummler
Retinoid metabolism and transplacental pharmacokinetics in the cynomolgus monkey following a nonteratogenic dosing regimen with all-trans-retinoic acid.
Teratology 1996;54(5):255-65.
1996: Liliane Didierjean; Pierre Carraux; D Grand; J O Sass; Heinz Nau; Jean-Hilaire Saurat
Topical retinaldehyde increases skin content of retinoic acid and exerts biologic activity in mouse skin.
The Journal of investigative dermatology 1996;107(5):714-9.
1996: Vladimir Berezin; Anna Christensen; U Bojic; A Foley; Heinz Nau; Ciaran M Regan; K Edvardsen; Elisabeth Bock
Teratogenic potency of valproate analogues evaluated by quantitative estimation of cellular morphology in vitro.
Toxicology in vitro : an international journal published in association with BIBRA 1996;10(5):585-94.
1996: J O Sass; Liliane Didierjean; Pierre Carraux; Claudia Plum; Heinz Nau; Jean-Hilaire Saurat
Metabolism of topical retinaldehyde and retinol by mouse skin in vivo: predominant formation of retinyl esters and identification of 14-hydroxy-4, 14-retro-retinol.
Experimental dermatology 1996;5(5):267-71.
1996: Heinz Nau; Mohamed Elmazar or El-Mazar; Ralph Rühl; R Thiel; J O Sass
All-trans-retinoyl-beta-glucuronide is a potent teratogen in the mouse because of extensive metabolism to all-trans-retinoic acid.
Teratology 1996;54(3):150-6.
1996: G Tzimas; M D Collins; H Bürgin; H Hummler; Heinz Nau
Embryotoxic doses of vitamin A to rabbits result in low plasma but high embryonic concentrations of all-trans-retinoic acid: risk of vitamin A exposure in humans.
The Journal of nutrition 1996;126(9):2159-71.
1996: U Bojic; Mohamed Elmazar or El-Mazar; R S Hauck; Heinz Nau
Further branching of valproate-related carboxylic acids reduces the teratogenic activity, but not the anticonvulsant effect.
Chemical research in toxicology 1996;9(5):866-70.
1996: S Koch; E Jäger-Roman; G Lösche; Heinz Nau; D Rating; Hans Helge
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Acta paediatrica (Oslo, Norway : 1992) 1996;85(6):739-46.
1996: G Tzimas; M D Collins; Heinz Nau
Identification of 14-hydroxy-4,14-retro-retinol as an in vivo metabolite of vitamin A.
Biochimica et biophysica acta 1996;1301(1-2):1-6.
1996: H M Arafa; F M Hamada; Mohamed Elmazar or El-Mazar; Heinz Nau
Fully automated determination of selective retinoic acid receptor ligands in mouse plasma and tissue by reversed-phase liquid chromatography coupled on-line with solid-phase extraction.
Journal of chromatography. A 1996;729(1-2):125-36.
1996: Mohamed Elmazar or El-Mazar; U Reichert; B Shroot; Heinz Nau
Pattern of retinoid-induced teratogenic effects: possible relationship with relative selectivity for nuclear retinoid receptors RAR alpha, RAR beta, and RAR gamma.
Teratology 1996;53(3):158-67.
1996: M Foerster; JO Sass; Ralph Rühl; Heinz Nau
Comparative studies on effects of all-trans-retinoic acid and all-trans-retinoyl-beta-d-glucuronide on the development of foetal mouse thymus in an organ culture system.
Toxicology in vitro : an international journal published in association with BIBRA 1996;10(1):7-15.
1996: J O Sass; E Masgrau; Pierre Piletta; Heinz Nau; Jean-Hilaire Saurat
Plasma retinoids after topical use of retinaldehyde on human skin.
Skin pharmacology : the official journal of the Skin Pharmacology Society 1996;9(5):322-6.
1996: H J Schmahl; L Dencker; Claudia Plum; Ibrahim Chahoud; Heinz Nau
Stereoselective distribution of the teratogenic thalidomide analogue EM12 in the early embryo of marmoset monkey, Wistar rat and NMRI mouse.
Archives of toxicology 1996;70(11):749-56.
1996: T Arnhold; G Tzimas; W Wittfoht; S Plonait; Heinz Nau
Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption.
Life sciences 1996;59(12):PL169-77.
1996: K Ehlers; Mohamed Elmazar or El-Mazar; Heinz Nau
Methionine reduces the valproic acid-induced spina bifida rate in mice without altering valproic acid kinetics.
The Journal of nutrition 1996;126(1):67-75.
1995: Heinz Nau
Chemical structure--teratogenicity relationships, toxicokinetics and metabolism in risk assessment of retinoids.
Toxicology letters 1995;82-83():975-9.
1995: J O Sass; E Masgrau; Jean-Hilaire Saurat; Heinz Nau
Metabolism of oral 9-cis-retinoic acid in the human. Identification of 9-cis-retinoyl-beta-glucuronide and 9-cis-4-oxo-retinoyl-beta-glucuronide as urinary metabolites.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(9):887-91.
1995: G Tzimas; M D Collins; Heinz Nau
Developmental stage-associated differences in the transplacental distribution of 13-cis- and all-trans-retinoic acid as well as their glucuronides in rats and mice.
Toxicology and applied pharmacology 1995;133(1):91-101.
1995: J O Sass; J Hartmann; Ibrahim Chahoud; B Shroot; Heinz Nau
Transplacental pharmacokinetics of a synthetic retinoid which is not bound by mouse embryonic cellular retinoic acid-binding protein.
Toxicology letters 1995;75(1-3):159-68.
1995: M D Collins; G Tzimas; H Bürgin; H Hummler; Heinz Nau
Single versus multiple dose administration of all-trans-retinoic acid during organogenesis: differential metabolism and transplacental kinetics in rat and rabbit.
Toxicology and applied pharmacology 1995;130(1):9-18.
1995: Heinz Nau; G Tzimas; M Mondry; Claudia Plum; H L Spohr
Antiepileptic drugs alter endogenous retinoid concentrations: a possible mechanism of teratogenesis of anticonvulsant therapy.
Life sciences 1995;57(1):53-60.
1994: S Belz; C Frickel; C Wolfrom; Heinz Nau; Günter Henze
High-performance liquid chromatographic determination of methotrexate, 7-hydroxymethotrexate, 5-methyltetrahydrofolic acid and folinic acid in serum and cerebrospinal fluid.
Journal of chromatography. B, Biomedical applications 1994;661(1):109-18.
1994: G Tzimas; J O Sass; W Wittfoht; Mohamed Elmazar or El-Mazar; K Ehlers; Heinz Nau
Identification of 9,13-dicis-retinoic acid as a major plasma metabolite of 9-cis-retinoic acid and limited transfer of 9-cis-retinoic acid and 9,13-dicis-retinoic acid to the mouse and rat embryos.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(6):928-36.
1994: William J Scott; R Walter; G Tzimas; J O Sass; Heinz Nau; M D Collins
Endogenous status of retinoids and their cytosolic binding proteins in limb buds of chick vs mouse embryos.
Developmental biology 1994;165(2):397-409.
1994: M D Collins; G Tzimas; H Hummler; H Bürgin; Heinz Nau
Comparative teratology and transplacental pharmacokinetics of all-trans-retinoic acid, 13-cis-retinoic acid, and retinyl palmitate following daily administrations in rats.
Toxicology and applied pharmacology 1994;127(1):132-44.
1994: J E Fisher; K D Acuff-Smith; M A Schilling; Heinz Nau; Charles V Vorhees
Trans-2-ene-valproic acid is less behaviorally teratogenic than an equivalent dose of valproic acid in rats.
Teratology 1994;49(6):479-86.
1994: J O Sass; A Forster; K W Bock; Heinz Nau
Glucuronidation and isomerization of all-trans- and 13-cis-retinoic acid by liver microsomes of phenobarbital- or 3-methylcholanthrene-treated rats.
Biochemical pharmacology 1994;47(3):485-92.
1994: J O Sass; G Tzimas; Heinz Nau
9-cis-retinoyl-beta-D-glucuronide is a major metabolite of 9-cis-retinoic acid.
Life sciences 1994;54(6):PL69-74.
1994: Heinz Nau
Retinoid teratogenesis: toxicokinetics and structure-specificity.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1994;16():118-27.
1994: G Tzimas; H Bürgin; M D Collins; H Hummler; Heinz Nau
The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-retinoic acid.
Archives of toxicology 1994;68(2):119-28.
1994: Heinz Nau
Valproic acid-induced neural tube defects.
Ciba Foundation symposium 1994;181():144-52; discussion 152-60.
1994: Wolfgang Heger; H J Schmahl; S Klug; A Felies; Heinz Nau; Hans-Joachim Merker; Diether Neubert
Embryotoxic effects of thalidomide derivatives in the non-human primate callithrix jacchus. IV. Teratogenicity of micrograms/kg doses of the EM12 enantiomers.
Teratogenesis, carcinogenesis, and mutagenesis 1994;14(3):115-22.
1993: Mohamed Elmazar or El-Mazar; R S Hauck; Heinz Nau
Anticonvulsant and neurotoxic activities of twelve analogues of valproic acid.
Journal of pharmaceutical sciences 1993;82(12):1255-8.
1993: S L Plonait; Heinz Nau; Rolf F Maier; W Wittfoht; Michael Obladen
Exposure of newborn infants to di-(2-ethylhexyl)-phthalate and 2-ethylhexanoic acid following exchange transfusion with polyvinylchloride catheters.
Transfusion 1993;33(7):598-605.
1993: Mohamed Elmazar or El-Mazar; Heinz Nau
Trimethoprim potentiates valproic acid-induced neural tube defects (NTDs) in mice.
Reproductive toxicology (Elmsford, N.Y.) 1993;7(3):249-54.
1993: H Siemes; Heinz Nau; K Schultze; W Wittfoht; E Drews; J Penzien; U Seidel
Valproate (VPA) metabolites in various clinical conditions of probable VPA-associated hepatotoxicity.
Epilepsia 1993;34(2):332-46.
1993: Heinz Nau
Embryotoxicity and teratogenicity of topical retinoic acid.
Skin pharmacology : the official journal of the Skin Pharmacology Society 1993;6 Suppl 1():35-44.
1992: H Siemes; Heinz Nau; U Seidel; H J Gramm
[Irreversible valproate-associated liver failure].
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft für Kinderheilkunde 1992;140(12):869-75.
1992: K Ehlers; H Stürje; Hans-Joachim Merker; Heinz Nau
Spina bifida aperta induced by valproic acid and by all-trans-retinoic acid in the mouse: distinct differences in morphology and periods of sensitivity.
Teratology 1992;46(2):117-30.
1992: R S Hauck; Heinz Nau
The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA): asymmetric synthesis and highly stereoselective teratogenicity in mice.
Pharmaceutical research 1992;9(7):850-5.
1992: M D Collins; C Eckhoff; W Slikker; J R Bailey; Heinz Nau
Quantitative plasma disposition of retinol and retinyl esters after high-dose oral vitamin A administration in the cynomolgus monkey.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1992;19(1):109-16.
1992: Heinz Nau; H Siemes
Differentiation between valproate-induced anticonvulsant effect, teratogenicity and hepatotoxicity. Aspects of species variation, pharmacokinetics, metabolism and implications of structural specificity for the development of alternative antiepileptic agents such as delta 2-valproate.
Pharmaceutisch weekblad. Scientific edition 1992;14(3A):101-7.
1992: B Schulte-Hobein; D Schwartz-Bickenbach; S Abt; Claudia Plum; Heinz Nau
Cigarette smoke exposure and development of infants throughout the first year of life: influence of passive smoking and nursing on cotinine levels in breast milk and infant's urine.
Acta paediatrica (Oslo, Norway : 1992) 1992;81(6-7):550-7.
1992: Mohamed Elmazar or El-Mazar; R Thiel; Heinz Nau
Effect of supplementation with folinic acid, vitamin B6, and vitamin B12 on valproic acid-induced teratogenesis in mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1992;18(3):389-94.
1992: C Wegner; Heinz Nau
Alteration of embryonic folate metabolism by valproic acid during organogenesis: implications for mechanism of teratogenesis.
Neurology 1992;42(4 Suppl 5):17-24.
1992: R S Hauck; Mohamed Elmazar or El-Mazar; Claudia Plum; Heinz Nau
The enantioselective teratogenicity of 2-n-propyl-4-pentynoic acid (4-yn-VPA) is due to stereoselective intrinsic activity and not differences in pharmacokinetics.
Toxicology letters 1992;60(2):145-53.
1992: M D Collins; W J Scott; S J Miller; D A Evans; Heinz Nau
Murine teratology and pharmacokinetics of the enantiomers of sodium 2-ethylhexanoate.
Toxicology and applied pharmacology 1992;112(2):257-65.
1992: K Ehlers; H Stürje; Hans-Joachim Merker; Heinz Nau
Valproic acid-induced spina bifida: a mouse model.
Teratology 1992;45(2):145-54.
1992: E Fisher; H Siemes; R Pund; W Wittfoht; Heinz Nau
Valproate metabolites in serum and urine during antiepileptic therapy in children with infantile spasms: abnormal metabolite pattern associated with reversible hepatotoxicity.
Epilepsia 1992;33(1):165-71.
1992: E Fisher; W Wittfoht; Heinz Nau
Quantitative determination of valproic acid and 14 metabolites in serum and urine by gas chromatography/mass spectrometry.
Biomedical chromatography : BMC 1992;6(1):24-9.
1992: M D Collins; C Eckhoff; Ibrahim Chahoud; G Bochert; Heinz Nau
4-Methylpyrazole partially ameliorated the teratogenicity of retinol and reduced the metabolic formation of all-trans-retinoic acid in the mouse.
Archives of toxicology 1992;66(9):652-9.
1992: Mohamed Elmazar or El-Mazar; Heinz Nau
Methotrexate increases valproic acid-induced developmental toxicity, in particular neural tube defects in mice.
Teratogenesis, carcinogenesis, and mutagenesis 1992;12(5):203-10.
1992: K Ehlers; H Stürje; Hans-Joachim Merker; Heinz Nau
The valproic acid metabolite E-2-n-propyl-2-pentenoic acid does not induce spina bifida in the mouse.
Developmental pharmacology and therapeutics 1992;19(4):196-204.
1991: Heinz Nau; R S Hauck; K Ehlers
Valproic acid-induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms.
Pharmacology & toxicology 1991;69(5):310-21.
1991: C Eckhoff; J R Bailey; M D Collins; W Slikker; Heinz Nau
Influence of dose and pharmaceutical formulation of vitamin A on plasma levels of retinyl esters and retinol and metabolic generation of retinoic acid compounds and beta-glucuronides in the cynomolgus monkey.
Toxicology and applied pharmacology 1991;111(1):116-27.
1991: C Eckhoff; M D Collins; Heinz Nau
Human plasma all-trans-, 13-cis- and 13-cis-4-oxoretinoic acid profiles during subchronic vitamin A supplementation: comparison to retinol and retinyl ester plasma levels.
The Journal of nutrition 1991;121(7):1016-25.
1991: R S Hauck; Heinz Nau; Mohamed Elmazar or El-Mazar
On the development of alternative antiepileptic drugs. Lack of enantioselectivity of the anticonvulsant activity, in contrast to teratogenicity, of 2-n-propyl-4-pentenoic acid and 2-n-propyl-4-pentynoic acid, analogues of the anticonvulsant drug valproic acid.
Die Naturwissenschaften 1991;78(6):272-4.
1991: Charles V Vorhees; K D Acuff-Smith; W P Weisenburger; D R Minck; J S Berry; K D Setchell; Heinz Nau
Lack of teratogenicity of trans-2-ene-valproic acid compared to valproic acid in rats.
Teratology 1991;43(6):583-90.
1991: J C Kraft; W Slikker; J R Bailey; L G Roberts; B Fischer; W Wittfoht; Heinz Nau
Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(2):317-24.
1991: Heinz Nau
Pharmacokinetic considerations in the design and interpretation of developmental toxicity studies.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1991;16(2):219-21.
1991: J E Fisher; Heinz Nau; Wolfgang Löscher
Alterations in the renal excretion of valproate and its metabolites after chronic treatment.
Epilepsia 1991;32(1):146-50.
1991: C Wegner; Heinz Nau
Diurnal variation of folate concentrations in mouse embryo and plasma: the protective effect of folinic acid on valproic-acid-induced teratogenicity is time dependent.
Reproductive toxicology (Elmsford, N.Y.) 1991;5(6):465-71.
1991: J Creech Kraft; C Eckhoff; D M Kochhar; G Bochert; Ibrahim Chahoud; Heinz Nau
Isotretinoin (13-cis-retinoic acid) metabolism, cis-trans isomerization, glucuronidation, and transfer to the mouse embryo: consequences for teratogenicity.
Teratogenesis, carcinogenesis, and mutagenesis 1991;11(1):21-30.
1990: C Eckhoff; Heinz Nau
Identification and quantitation of all-trans- and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in human plasma.
Journal of lipid research 1990;31(8):1445-54.
1990: C Eckhoff; W Wittfoht; Heinz Nau; W Slikker
Characterization of oxidized and glucuronidated metabolites of retinol in monkey plasma by thermospray liquid chromatography/mass spectrometry.
Biomedical & environmental mass spectrometry 1990;19(7):428-33.
1990: B Löfberg; Ibrahim Chahoud; G Bochert; Heinz Nau
Teratogenicity of the 13-cis and all-trans-isomers of the aromatic retinoid etretin: correlation to transplacental pharmacokinetics in mice during organogenesis after a single oral dose.
Teratology 1990;41(6):707-16.
1990: R S Hauck; C Wegner; P Blumtritt; J H Fuhrhop; Heinz Nau
Asymmetric synthesis and teratogenic activity of (R)- and (S)-2-ethylhexanoic acid, a metabolite of the plasticizer di-(2-ethylhexyl)phthalate.
Life sciences 1990;46(7):513-8.
1990: C Eckhoff; Heinz Nau
Vitamin A supplementation increases levels of retinoic acid compounds in human plasma: possible implications for teratogenesis.
Archives of toxicology 1990;64(6):502-3.
1990: B Löfberg; J Reiners; H Spielmann; Heinz Nau
Teratogenicity of steady-state concentrations of etretinate and metabolite acitretin maintained in maternal plasma and embryo by intragastric infusion during organogenesis in the mouse: a possible model for the extended elimination phase in human therapy.
Developmental pharmacology and therapeutics 1990;15(1):45-51.
1990: S Klug; C Lewandowski; F Zappel; Hans-Joachim Merker; Heinz Nau; Diether Neubert
Effects of valproic acid, some of its metabolites and analogues on prenatal development of rats in vitro and comparison with effects in vivo.
Archives of toxicology 1990;64(7):545-53.
1989: R S Hauck; Heinz Nau
[Structural bases of the teratogenic effects of the antiepileptic valproic acid. 2-n-propyl-4-pentenic acid, the first structural analogue with significantly higher teratogenic action than VPA].
Die Naturwissenschaften 1989;76(11):528-9.
1989: R S Hauck; Heinz Nau
Asymmetric synthesis and enantioselective teratogenicity of 2-n-propyl-4-pentenoic acid (4-en-VPA), an active metabolite of the anticonvulsant drug, valproic acid.
Toxicology letters 1989;49(1):41-8.
1989: C Eckhoff; B Löfberg; Ibrahim Chahoud; G Bochert; Heinz Nau
Transplacental pharmacokinetics and teratogenicity of a single dose of retinol (vitamin A) during organogenesis in the mouse.
Toxicology letters 1989;48(2):171-84.
1989: J Creech Kraft; B Löfberg; Ibrahim Chahoud; G Bochert; Heinz Nau
Teratogenicity and placental transfer of all-trans-, 13-cis-, 4-oxo-all-trans-, and 4-oxo-13-cis-retinoic acid after administration of a low oral dose during organogenesis in mice.
Toxicology and applied pharmacology 1989;100(1):162-76.
1989: S Klug; J Creech Kraft; E Wildi; Hans-Joachim Merker; T V Persaud; Heinz Nau; Diether Neubert
Influence of 13-cis and all-trans retinoic acid on rat embryonic development in vitro: correlation with isomerisation and drug transfer to the embryo.
Archives of toxicology 1989;63(3):185-92.
1989: H J Schmahl; Wolfgang Heger; Heinz Nau
The enantiomers of the teratogenic thalidomide analogue EM 12. 2. Chemical stability, stereoselectivity of metabolism and renal excretion in the marmoset monkey.
Toxicology letters 1989;45(1):23-33.
1988: W Wittfoht; W J Scott; Heinz Nau
Assay of methoxyacetic acid in body fluids and tissues by gas chromatography-mass spectrometry following tert.-butyldimethylsilylation.
Journal of chromatography 1988;448(3):433-8.
1988: H H Schmidt; Heinz Nau; W Wittfoht; J Gerlach; K E Prescher; M M Klein; F Niroomand; E Böhme
Arginine is a physiological precursor of endothelium-derived nitric oxide.
European journal of pharmacology 1988;154(2):213-6.
1988: H Siemes; H L Spohr; T Michael; Heinz Nau
Therapy of infantile spasms with valproate: results of a prospective study.
Epilepsia 1988;29(5):553-60.
1988: Heinz Nau
[Pharmacokinetic principles of the teratogenicity of drugs].
Der Internist 1988;29(3):179-92.
1988: D Schwartz-Bickenbach; B Schulte-Hobein; Claudia Plum; S Abt; Heinz Nau
[Cotinine burden of infants due to exposure through passive smoking].
Deutsche medizinische Wochenschrift (1946) 1988;113(4):159.
1988: Heinz Nau; C Lewandowski; S Klug; Diether Neubert
Pharmacokinetic aspects of drug effects in vitro (II) placental transfer to the embryo and activity of some carboxylic acids structurally related to valproic acid in whole embryos in culture.
Toxicology in vitro : an international journal published in association with BIBRA 1988;2(3):169-74.
1988: W Kuhnz; S Koch; Hans Helge; Heinz Nau
Primidone and phenobarbital during lactation period in epileptic women: total and free drug serum levels in the nursed infants and their effects on neonatal behavior.
Developmental pharmacology and therapeutics 1988;11(3):147-54.
1988: Wolfgang Heger; S Klug; H J Schmahl; Heinz Nau; Hans-Joachim Merker; Diether Neubert
Embryotoxic effects of thalidomide derivatives on the non-human primate Callithrix jacchus; 3. Teratogenic potency of the EM 12 enantiomers.
Archives of toxicology 1988;62(2-3):205-8.
1988: H J Schmahl; Heinz Nau; Diether Neubert
The enantiomers of the teratogenic thalidomide analogue EM 12: 1. Chiral inversion and plasma pharmacokinetics in the marmoset monkey.
Archives of toxicology 1988;62(2-3):200-4.
1988: J Reiners; B Löfberg; J C Kraft; D M Kochhar; Heinz Nau
Transplacental pharmacokinetics of teratogenic doses of etretinate and other aromatic retinoids in mice.
Reproductive toxicology (Elmsford, N.Y.) 1988;2(1):19-29.
1987: J C Kraft; D M Kochhar; W J Scott; Heinz Nau
Low teratogenicity of 13-cis-retinoic acid (isotretinoin) in the mouse corresponds to low embryo concentrations during organogenesis: comparison to the all-trans isomer.
Toxicology and applied pharmacology 1987;87(3):474-82.
1987: D Schwartz-Bickenbach; B Schulte-Hobein; S Abt; Claudia Plum; Heinz Nau
Smoking and passive smoking during pregnancy and early infancy: effects on birth weight, lactation period, and cotinine concentrations in mother's milk and infant's urine.
Toxicology letters 1987;35(1):73-81.
1986: E Jäger-Roman; A Deichl; S Jakob; A M Hartmann; S Koch; D Rating; R Steldinger; Heinz Nau; Hans Helge
Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid.
The Journal of pediatrics 1986;108(6):997-1004.
1986: C Lewandowski; S Klug; Heinz Nau; Diether Neubert
Pharmacokinetic aspects of drug effects in vitro: effects of serum protein binding on concentration and teratogenicity of valproic acid and 2-en-valproic acid in whole embryos in culture.
Archives of toxicology 1986;58(4):239-42.
1985: S Koch; I Göpfert-Geyer; I Häuser; A Hartmann; S Jakob; E Jäger-Roman; Heinz Nau; D Rating; Hans Helge
Neonatal behaviour disturbances in infants of epileptic women treated during pregnancy.
Progress in clinical and biological research 1985;163B():453-61.
1984: W Kuhnz; S Koch; S Jakob; A Hartmann; Hans Helge; Heinz Nau
Ethosuximide in epileptic women during pregnancy and lactation period. Placental transfer, serum concentrations in nursed infants and clinical status.
British journal of clinical pharmacology 1984;18(5):671-7.
1983: W Kuhnz; E Jäger-Roman; D Rating; A Deichl; J Kunze; Hans Helge; Heinz Nau
Carbamazepine and carbamazepine-10,11- epoxide during pregnancy and postnatal period in epileptic mother and their nursed infants: pharmacokinetics and clinical effects.
Pediatric pharmacology (New York, N.Y.) 1983;3(3-4):199-208.
1983: D Rating; E Jäger-Roman; Heinz Nau; W Kuhnz; Hans Helge
Enzyme induction in neonates after fetal exposure to antiepileptic drugs.
Pediatric pharmacology (New York, N.Y.) 1983;3(3-4):209-18.
1983: D Rating; Heinz Nau; W Kuhnz; E Jäger-Roman; Hans Helge
[Antiepileptic drugs in the newborn. Clinical and pharmacological data].
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft für Kinderheilkunde 1983;131(1):6-12.
1982: Heinz Nau; W Kuhnz; H J Egger; D Rating; Hans Helge
Anticonvulsants during pregnancy and lactation. Transplacental, maternal and neonatal pharmacokinetics.
Clinical pharmacokinetics 1982;7(6):508-43.
1982: D Rating; Heinz Nau; E Jäger-Roman; I Göpfert-Geyer; S Koch; G Beck-Mannagetta; D Schmidt; Hans Helge
Teratogenic and pharmacokinetic studies of primidone during pregnancy and in the offspring of epileptic women.
Acta paediatrica Scandinavica 1982;71(2):301-11.
1981: Heinz Nau; D Rating; S Koch; I Häuser; Hans Helge
Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.
The Journal of pharmacology and experimental therapeutics 1981;219(3):768-77.
1980: Heinz Nau; D Rating; I Häuser; E Jäger; S Koch; Hans Helge
Placental transfer and pharmacokinetics of primidone and its metabolites phenobarbital, PEMA and hydroxyphenobarbital in neonates and infants of epileptic mothers.
European journal of clinical pharmacology 1980;18(1):31-42.