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Roland Nau

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Sandra Ribes; Sandra Schütze; Simone C Tauber; Tommy Regen; Uwe-Karsten Hanisch; Matthias Mack; Tanja Meister; Alexander Mildner; Roland Nau
Resistance of the Brain to Escherichia coli K1 Infection Depends on MyD88 Signaling and the Contribution of Neutrophils and Monocytes.
Jörg Scheffel; Mareike Schnaars; Stefanie Seifert; Mikael Simons; Denise van Rossum; Johannes T Wessels; Hendrikus W G M Boddeke; Wolfgang Brück; Han-Ning Chuang; Robert A Harris; Tanja Jürgens; Helmut Kettenmann; Doron Merkler; Roland Nau; Roham Parsa; Tobias Pukrop; Tommy Regen; Sandra Ribes; Uwe-Karsten Hanisch
Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia.
Marija Djukic; Helmut Eiffert; Peter Lange; Roland Nau; Katja Neubieser; Carsten Schmidt-Samoa; Annette Spreer; Holger Schmidt
Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis.

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2013: Sandra Ribes; Sandra Schütze; Simone C Tauber; Tommy Regen; Uwe-Karsten Hanisch; Matthias Mack; Tanja Meister; Alexander Mildner; Roland Nau
Resistance of the Brain to Escherichia coli K1 Infection Depends on MyD88 Signaling and the Contribution of Neutrophils and Monocytes.
Infection and immunity 2013;81(5):1810-9.
2012: Jörg Scheffel; Mareike Schnaars; Stefanie Seifert; Mikael Simons; Denise van Rossum; Johannes T Wessels; Hendrikus W G M Boddeke; Wolfgang Brück; Han-Ning Chuang; Robert A Harris; Tanja Jürgens; Helmut Kettenmann; Doron Merkler; Roland Nau; Roham Parsa; Tobias Pukrop; Tommy Regen; Sandra Ribes; Uwe-Karsten Hanisch
Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia.
Glia 2012;60(12):1930-43.
2012: Marija Djukic; Helmut Eiffert; Peter Lange; Roland Nau; Katja Neubieser; Carsten Schmidt-Samoa; Annette Spreer; Holger Schmidt
Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis.
Journal of neurology 2012;259(4):630-6.
2012: Sandra Redlich; Sandra Ribes; Sandra Schütze; Dirk Czesnik; Roland Nau
Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 and Streptococcus pneumoniae R6 by microglial cells.
Journal of neuroimmunology 2012;244(1-2):32-4.
2012: David Liebetanz; Roland Nau; Christina Schiffner; Sandra Schütze; Joachim Gerber; Hubertus Jarry; Florian Klinker; Simone C Tauber
Pre-infection physical exercise decreases mortality and stimulates neurogenesis in bacterial meningitis.
Journal of neuroinflammation 2012;9():168.
2012: Sandra Schütze; Moritz Zeretzke; Sandra Ribes; Wolfgang Brück; Stephanie Bunkowski; Tobias Loleit; Roland Nau
Additive microglia-mediated neuronal injury caused by amyloid-β and bacterial TLR agonists in murine neuron-microglia co-cultures quantified by an automated image analysis using cognition network technology.
Journal of Alzheimer's disease : JAD 2012;31(3):651-7.
2011: S C Tauber; Wolfgang Brück; Stephanie Bunkowski; Roland Nau
Septic metastatic encephalitis: coexistence of brain damage and repair.
Neuropathology and applied neurobiology 2011;37(7):768-76.
2011: Simone C Tauber; Sandra Ribes; Annette Spreer; Stephanie Bunkowski; Sandra Ebert; Helmut Eiffert; Volker Fingerle; Torsten Heinz; Olaf Jahn; Dominik Kugelstadt; Roland Nau
Long-term intrathecal infusion of outer surface protein C from Borrelia burgdorferi causes axonal damage.
Journal of neuropathology and experimental neurology 2011;70(9):748-57.
2011: S Ebert; K-P Schweiger; Roland Nau
Candida esophagitis as the cause of swallowing disturbances in an 85-year-old patient with myasthenia gravis.
Zeitschrift für Gerontologie und Geriatrie 2011;44(4):268-9.
2011: Marija Djukic; C Schmidt-Samoa; Roland Nau; Nicole von Steinbüchel; Helmut Eiffert; Hauke Schmidt
The diagnostic spectrum in patients with suspected chronic Lyme neuroborreliosis--the experience from one year of a university hospital's Lyme neuroborreliosis outpatients clinic.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2011;18(4):547-55.
2011: Kathrin Fronek; Peter Lange; Helmut Eiffert; Annette Spreer; Roland Nau
Bacterial contamination and the transport vial material affect cerebrospinal fluid concentrations of β-Amyloid and Tau protein as determined by enzyme immunoassay.
Dementia and geriatric cognitive disorders 2011;32(2):126-34.
2011: Klaus Jung; Peter Lange; Roland Nau; Markus Otto; Joachim Blocher; Marija Djukic; Joachim Gerber; Christoph Goerdt; Annette Spreer; Holger Schmidt
The use of S100B and Tau protein concentrations in the cerebrospinal fluid for the differential diagnosis of bacterial meningitis: a retrospective analysis.
European neurology 2011;66(3):128-32.
2010: Sandra Ribes; Nina Adam; Sandra Ebert; Tommy Regen; Stephanie Bunkowski; Uwe-Karsten Hanisch; Roland Nau
The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells.
Neuroscience letters 2010;482(1):17-20.
2010: Sandra Ebert; Roland Nau; Uwe Michel
Role of activin in bacterial infections: a potential target for immunointervention?
Immunotherapy 2010;2(5):673-84.
2010: Hauke Schmidt; Joachim Gerber; K Stuertz; Marija Djukic; Stephanie Bunkowski; FR Fischer; Markus Otto; Roland Nau
S100B in the cerebrospinal fluid--a marker for glial damage in the rabbit model of pneumococcal meningitis.
Neuroscience letters 2010;475(2):104-7.
2010: Sandra Ebert; Miriam Goos; Lena Rollwagen; Daniel Baake; Wolf-Dieter Zech; Hermann Esselmann; Jens Wiltfang; Brit Mollenhauer; Reinhard Schliebs; Joachim Gerber; Roland Nau
Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases.
Journal of neuroscience research 2010;88(5):1124-36.
2010: Sandra Ribes; Sandra Ebert; Tommy Regen; Amit Agarwal; Simone C Tauber; Dirk Czesnik; Annette Spreer; Stephanie Bunkowski; Helmut Eiffert; Uwe-Karsten Hanisch; Sven Hammerschmidt; Roland Nau
Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia.
Infection and immunity 2010;78(2):865-71.
2010: Sandra Ribes; Sandra Ebert; Tommy Regen; Dirk Czesnik; Jörg Scheffel; Andre Zeug; Stephanie Bunkowski; Helmut Eiffert; Uwe-Karsten Hanisch; Sven Hammerschmidt; Roland Nau
Fibronectin stimulates Escherichia coli phagocytosis by microglial cells.
Glia 2010;58(3):367-76.
2009: Simone C Tauber; Stephanie Bunkowski; Sandra Ebert; Daniela Schulz; Benedikt Kellert; Roland Nau; Joachim Gerber
Enriched environment fails to increase meningitis-induced neurogenesis and spatial memory in a mouse model of pneumococcal meningitis.
Journal of neuroscience research 2009;87(8):1877-83.
2009: Wulf-Rainer C Mattiesen; Simone C Tauber; Joachim Gerber; Stephanie Bunkowski; Wolfgang Brück; Roland Nau
Increased neurogenesis after hypoxic-ischemic encephalopathy in humans is age related.
Acta neuropathologica 2009;117(5):525-34.
2009: Manoj Kumar Jaiswal; Wolf-Dieter Zech; Miriam Goos; Christine Leutbecher; Alberto Ferri; Annette Zippelius; Maria Teresa Carrì; Roland Nau; Bernhard U Keller
Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease.
BMC neuroscience 2009;10():64.
2009: Joachim Gerber; R-C Seitz; Stephanie Bunkowski; Wolfgang Brück; Roland Nau
Evidence for frequent focal and diffuse acute axonal injury in human bacterial meningitis.
Clinical neuropathology 2009;28(1):33-9.
2009: Asparouh I Iliev; Jasmin Roya Djannatian; Felipe Opazo; Joachim Gerber; Roland Nau; Tim Mitchell; Fred S Wouters
Rapid microtubule bundling and stabilization by the Streptococcus pneumoniae neurotoxin pneumolysin in a cholesterol-dependent, non-lytic and Src-kinase dependent manner inhibits intracellular trafficking.
Molecular microbiology 2009;71(2):461-77.
2008: Simone C Tauber; Stephanie Bunkowski; Christina Schlumbohm; Malte Rühlmann; Eberhard Fuchs; Roland Nau; Joachim Gerber
No long-term effect two years after intrauterine exposure to dexamethasone on dentate gyrus volume, neuronal proliferation and differentiation in common marmoset monkeys.
Brain pathology (Zurich, Switzerland) 2008;18(4):497-503.
2008: Marija Djukic; Hauke Schmidt; C Mazurek; F König; Stefan Schweyer; Roland Nau
[A patient with Churg-Strauss syndrome presenting as Guillain-Barré syndrome].
Der Nervenarzt 2008;79(4):457-61.
2007: Annette Spreer; Joachim Gerber; Mareike Hanssen; Roland Nau
No neuroprotective effect of erythropoietin under clinical treatment conditions in a rabbit model of Escherichia coli meningitis.
Pediatric research 2007;62(6):680-3.
2007: Miriam Goos; Peter Lange; Uwe-Karsten Hanisch; Marco Prinz; Jörg Scheffel; Reiner Bergmann; Sandra Ebert; Roland Nau
Fibronectin is elevated in the cerebrospinal fluid of patients suffering from bacterial meningitis and enhances inflammation caused by bacterial products in primary mouse microglial cell cultures.
Journal of neurochemistry 2007;102(6):2049-60.
2007: Simone C Tauber; Roland Nau; Joachim Gerber
Systemic infections in multiple sclerosis and experimental autoimmune encephalomyelitis.
Archives of physiology and biochemistry 2007;113(3):124-30.
2007: Roland Nau; Holger Schmidt
Long-term neuropsychological deficits after central nervous system infections despite adequate therapy.
Journal of neurology 2007;254 Suppl 2():II80-3.
2007: Sandra Ebert; Moritz Zeretzke; Roland Nau; Uwe Michel
Microglial cells and peritoneal macrophages release activin A upon stimulation with Toll-like receptor agonists.
Neuroscience letters 2007;413(3):241-4.
2007: Asparouh I Iliev; Jasmin Roya Djannatian; Roland Nau; Tim Mitchell; Fred S Wouters
Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2897-902.
2007: Miriam Goos; Wolf-Dieter Zech; Manoj Kumar Jaiswal; Saju Balakrishnan; Sandra Ebert; Timothy Mitchell; Maria Teresa Carrì; Bernhard U Keller; Roland Nau
Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury.
BMC infectious diseases 2007;7():131.
2007: Annette Spreer; Christian von Ruden; Tim Mitchell; Helmut Eiffert; Roland Nau
Influence of subinhibitory concentrations of protein-synthesis-inhibiting antibiotics on production and release of the pneumococcal virulence factor pneumolysin in vitro.
Chemotherapy 2007;53(5):327-31.
2007: Isabel Herrmann; Markus Kellert; Annette Spreer; Joachim Gerber; Helmut Eiffert; Marco Prinz; Roland Nau
Minocycline delays but does not attenuate the course of experimental autoimmune encephalomyelitis in Streptococcus pneumoniae-infected mice.
The Journal of antimicrobial chemotherapy 2007;59(1):74-9.
2006: Sandra Ebert; David J Phillips; Peter Jenzewski; Roland Nau; Anne E O'Connor; Uwe Michel
Activin A concentrations in human cerebrospinal fluid are age-dependent and elevated in meningitis.
Journal of the neurological sciences 2006;250(1-2):50-7.
2006: Annette Spreer; Joachim Gerber; Daniel Baake; Mareike Hanssen; Gerald Huether; Roland Nau
Antiinflammatory but no neuroprotective effects of melatonin under clinical treatment conditions in rabbit models of bacterial meningitis.
Journal of neuroscience research 2006;84(7):1575-9.
2006: Marija Djukic; Alexander Mildner; Hauke Schmidt; Dirk Czesnik; Wolfgang Brück; Josef Priller; Roland Nau; Marco Prinz
Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice.
Brain : a journal of neurology 2006;129(Pt 9):2394-403.
2006: Annette Spreer; Joachim Gerber; Mareike Hanssen; Stefanie Schindler; Corinna Hermann; Peter Lange; Helmut Eiffert; Roland Nau
Dexamethasone increases hippocampal neuronal apoptosis in a rabbit model of Escherichia coli meningitis.
Pediatric research 2006;60(2):210-5.
2006: Isabel Herrmann; Markus Kellert; Hauke Schmidt; Alexander Mildner; Uwe-Karsten Hanisch; Wolfgang Brück; Marco Prinz; Roland Nau
Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2.
Infection and immunity 2006;74(8):4841-8.
2006: Simone C Tauber; Christina Schlumbohm; Lenka Schilg; Eberhard Fuchs; Roland Nau; Joachim Gerber
Intrauterine exposure to dexamethasone impairs proliferation but not neuronal differentiation in the dentate gyrus of newborn common marmoset monkeys.
Brain pathology (Zurich, Switzerland) 2006;16(3):209-17.
2006: Hauke Schmidt; Stefan Cohrs; T Heinemann; C Goerdt; Marija Djukic; B Heimann; C-W Wallesch; Roland Nau
Sleep disorders are long-term sequelae of both bacterial and viral meningitis.
Journal of neurology, neurosurgery, and psychiatry 2006;77(4):554-8.
2006: Hauke Schmidt; B Heimann; Marija Djukic; C Mazurek; Carsten Fels; C-W Wallesch; Roland Nau
Neuropsychological sequelae of bacterial and viral meningitis.
Brain : a journal of neurology 2006;129(Pt 2):333-45.
2006: Peter Ratzka; Johannes C M Schlachetzki; Mathias Bähr; Roland Nau
Varicella zoster virus cerebellitis in a 66-year-old patient without herpes zoster.
Lancet 2006;367(9505):182.
2005: Simone C Tauber; Christine Stadelmann; Annette Spreer; Wolfgang Brück; Roland Nau; Joachim Gerber
Increased expression of BDNF and proliferation of dentate granule cells after bacterial meningitis.
Journal of neuropathology and experimental neurology 2005;64(9):806-15.
2005: Sandra Ebert; Gunnar P H Dietz; Tim Mitchell; Uwe Michel; Mathias Bähr; Roland Nau
Limited protection of TAT-Bcl-X(L) against pneumolysin-induced neuronal cell death.
Neuroscience letters 2005;384(3):349-53.
2005: Miriam Lotz; Sandra Ebert; Hermann Esselmann; Asparouh I Iliev; Marco Prinz; Nicole Wiazewicz; Jens Wiltfang; Joachim Gerber; Roland Nau
Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures.
Journal of neurochemistry 2005;94(2):289-98.
2005: Roland Nau; Helmut Eiffert
Minimizing the release of proinflammatory and toxic bacterial products within the host: a promising approach to improve outcome in life-threatening infections.
FEMS immunology and medical microbiology 2005;44(1):1-16.
2005: Joachim Gerber; Miriam Lotz; Sandra Ebert; Susanne Kiel; Gerald Huether; Ulrich Kuhnt; Roland Nau
Melatonin is neuroprotective in experimental Streptococcus pneumoniae meningitis.
The Journal of infectious diseases 2005;191(5):783-90.
2005: Sandra Ebert; Joachim Gerber; Steffi Bader; Frank Mühlhauser; Katrin Brechtel; Tim Mitchell; Roland Nau
Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination.
Journal of neuroimmunology 2005;159(1-2):87-96.
2005: Marija Djukic; Tobias Böttcher; Andreas Wellmer; Joachim Gerber; Viola V Brocke; Helmut Eiffert; Roland Nau
Moxifloxacin in experimental Streptococcus pneumoniae cerebritis and meningitis.
Neurocritical care 2005;2(3):325-9.
2004: Tobias Böttcher; Hao Ren; Michel Goiny; Joachim Gerber; Jens Lykkesfeldt; Ulrich Kuhnt; Miriam Lotz; Stephanie Bunkowski; Carola Werner; Ingmar Schau; Annette Spreer; Stephan Christen; Roland Nau
Clindamycin is neuroprotective in experimental Streptococcus pneumoniae meningitis compared with ceftriaxone.
Journal of neurochemistry 2004;91(6):1450-60.
2004: Annette Spreer; Astrid Lis; Joachim Gerber; Ralf Rene Reinert; Helmut Eiffert; Roland Nau
Differences in clinical manifestation of Streptococcus pneumoniae infection are not correlated with in vitro production and release of the virulence factors pneumolysin and lipoteichoic and teichoic acids.
Journal of clinical microbiology 2004;42(7):3342-5.
2004: Joachim Gerber; Tobias Böttcher; Michael Hahn; Alexander Siemer; Stephanie Bunkowski; Roland Nau
Increased mortality and spatial memory deficits in TNF-alpha-deficient mice in ceftriaxone-treated experimental pneumococcal meningitis.
Neurobiology of disease 2004;16(1):133-8.
2004: Andreas Wellmer; Matthias Von Mering; Annette Spreer; Ricarda Diem; Helmut Eiffert; Christiane Noeske; Stephanie Bunkowski; Ralf Gold; Roland Nau
Experimental pneumococcal meningitis: impaired clearance of bacteria from the blood due to increased apoptosis in the spleen in Bcl-2-deficient mice.
Infection and immunity 2004;72(6):3113-9.
2004: Roland Nau; Joachim Gerber; Stephanie Bunkowski; Wolfgang Brück
Axonal injury, a neglected cause of CNS damage in bacterial meningitis.
Neurology 2004;62(3):509-11.
2004: Asparouh I Iliev; Argyrios K Stringaris; Roland Nau; Harald Neumann
Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):412-4.
2003: H Schmidt; Ulrich Kaboth; U Brinck; Peter Ratzka; Hans-Heino Rustenbeck; Roland Nau
[Polyneuropathy as a sole syndrome in malignant thymoma].
Der Nervenarzt 2003;74(10):888-91.
2003: Joachim Gerber; Tobias Böttcher; Judith Bering; Stephanie Bunkowski; Wolfgang Brück; Ulrich Kuhnt; Roland Nau
Increased neurogenesis after experimental Streptococcus pneumoniae meningitis.
Journal of neuroscience research 2003;73(4):441-6.
2003: Annette Spreer; Holger Kerstan; Tobias Böttcher; Joachim Gerber; Alexander Siemer; Gregor Zysk; Tim Mitchell; Helmut Eiffert; Roland Nau
Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone.
Antimicrobial agents and chemotherapy 2003;47(8):2649-54.
2003: Uwe Michel; Joachim Gerber; Anne E O'Connor; Stephanie Bunkowski; Wolfgang Brück; Roland Nau; David J Phillips
Increased activin levels in cerebrospinal fluid of rabbits with bacterial meningitis are associated with activation of microglia.
Journal of neurochemistry 2003;86(1):238-45.
2003: Tobias Böttcher; Matthias Von Mering; Sandra Ebert; Uta Meyding-Lamadé; Ulrich Kuhnt; Joachim Gerber; Roland Nau
Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections.
Neuroscience letters 2003;344(1):17-20.
2003: Matthias Von Mering; M Stiefel; K Brockmann; Roland Nau
Deep cerebral venous sinus thrombosis often presents with neuropsychologic symptoms.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2003;10(3):310-2.
2003: Uwe Michel; Sandra Ebert; David Phillips; Roland Nau
Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia.
European journal of endocrinology / European Federation of Endocrine Societies 2003;148(5):559-64.
2003: Tobias Böttcher; Michel Goiny; J Bering; S Domhof; Roland Nau; Urban Ungerstedt
Regional differences in glutamine synthetase inhibition by L-methionine sulfoximine: a microdialysis study in the rabbit brain.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2003;150(2):194-200.
2003: Joachim Gerber; Karin Pohl; Valeska Sander; Stephanie Bunkowski; Roland Nau
Rifampin followed by ceftriaxone for experimental meningitis decreases lipoteichoic acid concentrations in cerebrospinal fluid and reduces neuronal damage in comparison to ceftriaxone alone.
Antimicrobial agents and chemotherapy 2003;47(4):1313-7.
2003: Tobias Böttcher; Annette Spreer; Ivo Azeh; Roland Nau; Joachim Gerber
Matrix metalloproteinase-9 deficiency impairs host defense mechanisms against Streptococcus pneumoniae in a mouse model of bacterial meningitis.
Neuroscience letters 2003;338(3):201-4.
2003: Gregor Zysk; Gesina Bethe; Roland Nau; Daniela Koch; Valeska C D H Gräfin Von Bassewitz; Hans-Peter Heinz; Ralf Rene Reinert
Immune response to capsular polysaccharide and surface proteins of Streptococcus pneumoniae in patients with invasive pneumococcal disease.
The Journal of infectious diseases 2003;187(2):330-3.
2002: Argyrios K Stringaris; Jens Geisenhainer; Friederike Bergmann; Christoph Balshüsemann; Unaa Lee; Gregor Zysk; Tim Mitchell; Bernhard U Keller; Ulrich Kuhnt; Joachim Gerber; Annette Spreer; Mathias Bähr; Uwe Michel; Roland Nau
Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase.
Neurobiology of disease 2002;11(3):355-68.
2002: Andreas Wellmer; Gregor Zysk; Joachim Gerber; Tammo Kunst; Matthias Von Mering; Stephanie Bunkowski; Helmut Eiffert; Roland Nau
Decreased virulence of a pneumolysin-deficient strain of Streptococcus pneumoniae in murine meningitis.
Infection and immunity 2002;70(11):6504-8.
2002: Roland Nau; Sabine Haase; Stephanie Bunkowski; Wolfgang Brück
Neuronal apoptosis in the dentate gyrus in humans with subarachnoid hemorrhage and cerebral hypoxia.
Brain pathology (Zurich, Switzerland) 2002;12(3):329-36.
2002: Ivo Azeh; Joachim Gerber; Andreas Wellmer; Malte Wellhausen; Brigitte Koenig; Helmut Eiffert; Roland Nau
Protein synthesis inhibiting clindamycin improves outcome in a mouse model of Staphylococcus aureus sepsis compared with the cell wall active ceftriaxone.
Critical care medicine 2002;30(7):1560-4.
2002: Roland Nau; Wolfgang Brück
Neuronal injury in bacterial meningitis: mechanisms and implications for therapy.
Trends in neurosciences 2002;25(1):38-45.
2002: Roland Nau; Helmut Eiffert
Modulation of release of proinflammatory bacterial compounds by antibacterials: potential impact on course of inflammation and outcome in sepsis and meningitis.
Clinical microbiology reviews 2002;15(1):95-110.
2001: Gesina Bethe; Roland Nau; Andreas Wellmer; Regine Hakenbeck; Ralf Rene Reinert; Hans-Peter Heinz; Gregor Zysk
The cell wall-associated serine protease PrtA: a highly conserved virulence factor of Streptococcus pneumoniae.
FEMS microbiology letters 2001;205(1):99-104.
2001: Andreas Wellmer; Joachim Gerber; J Ragheb; Gregor Zysk; Tammo Kunst; Alexandr Smirnov; Wolfgang Brück; Roland Nau
Effect of deficiency of tumor necrosis factor alpha or both of its receptors on Streptococcus pneumoniae central nervous system infection and peritonitis.
Infection and immunity 2001;69(11):6881-6.
2001: Joachim Gerber; Wolfgang Brück; Christine Stadelmann; Stephanie Bunkowski; H Lassmann; Roland Nau
Expression of death-related proteins in dentate granule cells in human bacterial meningitis.
Brain pathology (Zurich, Switzerland) 2001;11(4):422-31.
2001: Joachim Gerber; Helmut Eiffert; H Fleischer; Andreas Wellmer; U Munzel; Roland Nau
Reduced release of DNA from streptococcus pneumoniae after treatment with rifampin in comparison to spontaneous growth and ceftriaxone treatment.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2001;20(7):490-3.
2001: Matthias Von Mering; Andreas Wellmer; Uwe Michel; Stephanie Bunkowski; A Tłustochowska; Wolfgang Brück; Ulrich Kuhnt; Roland Nau
Transcriptional regulation of caspases in experimental pneumococcal meningitis.
Brain pathology (Zurich, Switzerland) 2001;11(3):282-95.
2001: Joachim Gerber; Alexandr Smirnov; Andreas Wellmer; J Ragheb; J Prange; E Schütz; K Wettich; S Kalich; Roland Nau
Activity of LY333328 in experimental meningitis caused by a Streptococcus pneumoniae strain susceptible to penicillin.
Antimicrobial agents and chemotherapy 2001;45(7):2169-72.
2001: Joachim Gerber; G Raivich; Andreas Wellmer; Christiane Noeske; Tammo Kunst; A Werner; Wolfgang Brück; Roland Nau
A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease.
Acta neuropathologica 2001;101(5):499-508.
2001: Hauke Schmidt; A Tlustochowska; K Stuertz; Marija Djukic; Joachim Gerber; E Schütz; Ulrich Kuhnt; Roland Nau
Organotypic hippocampal cultures. A model of brain tissue damage in Streptococcus pneumoniae meningitis.
Journal of neuroimmunology 2001;113(1):30-9.
2001: Andreas Wellmer; J Prange; Joachim Gerber; Gregor Zysk; Peter Lange; Uwe Michel; Helmut Eiffert; Roland Nau
D- and L-lactate in rabbit and human bacterial meningitis.
Scandinavian journal of infectious diseases 2001;33(12):909-13.
2000: Andreas Wellmer; Christiane Noeske; Joachim Gerber; U Munzel; Roland Nau
Spatial memory and learning deficits after experimental pneumococcal meningitis in mice.
Neuroscience letters 2000;296(2-3):137-40.
2000: Uwe Michel; Sandra Ebert; O Schneider; Y Shintani; Stephanie Bunkowski; Alexandr Smirnov; Argyrios K Stringaris; Joachim Gerber; Wolfgang Brück; Roland Nau
Follistatin (FS) in human cerebrospinal fluid and regulation of FS expression in a mouse model of meningitis.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(6):809-16.
2000: Gregor Zysk; L Bejo; B K Schneider-Wald; Roland Nau; Hans-Peter Heinz
Induction of necrosis and apoptosis of neutrophil granulocytes by Streptococcus pneumoniae.
Clinical and experimental immunology 2000;122(1):61-6.
2000: Tobias Böttcher; Joachim Gerber; Andreas Wellmer; A V Smirnov; F Fakhrjanali; Eilhard Mix; J Pilz; Uwe K Zettl; Roland Nau
Rifampin reduces production of reactive oxygen species of cerebrospinal fluid phagocytes and hippocampal neuronal apoptosis in experimental Streptococcus pneumoniae meningitis.
The Journal of infectious diseases 2000;181(6):2095-8.
2000: O Schneider; Roland Nau; Uwe Michel
Comparative analysis of follistatin-, activin beta A- and activin beta B-mRNA steady-state levels in diverse porcine tissues by multiplex S1 nuclease analysis.
European journal of endocrinology / European Federation of Endocrine Societies 2000;142(5):537-44.
2000: Uwe Michel; Argyrios K Stringaris; Roland Nau; P Rieckmann
Differential expression of sense and antisense transcripts of the mitochondrial DNA region coding for ATPase 6 in fetal and adult porcine brain: identification of novel unusually assembled mitochondrial RNAs.
Biochemical and biophysical research communications 2000;271(1):170-80.
2000: Hayrettin Tumani; Alexandr Smirnov; S Barchfeld; U Olgemöller; K Maier; Peter Lange; Wolfgang Brück; Roland Nau
Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus.
Glia 2000;30(1):11-8.
2000: Alexandr Smirnov; Andreas Wellmer; Joachim Gerber; K Maier; S Henne; Roland Nau
Gemifloxacin is effective in experimental pneumococcal meningitis.
Antimicrobial agents and chemotherapy 2000;44(3):767-70.
2000: A V Smirnov; Hayrettin Tumani; S Henne; S Barchfeld; U Olgemöller; Jens Wiltfang; Peter Lange; Michael Mäder; Roland Nau
Glutamine synthetase in experimental meningitis: increased ratio of the subunits 3 and 2 may indicate enhanced activity.
Clinica chimica acta; international journal of clinical chemistry 2000;292(1-2):1-12.
2000: C Heer; K Stuertz; Ralf Rene Reinert; Michael Mäder; Roland Nau
Release of teichoic and lipoteichoic acids from 30 different strains of Streptococcus pneumoniae during exposure to ceftriaxone, meropenem, quinupristin/dalfopristin, rifampicin and trovafloxacin.
Infection 2000;28(1):13-20.
2000: Roland Nau
Osmotherapy for elevated intracranial pressure: a critical reappraisal.
Clinical pharmacokinetics 2000;38(1):23-40.
1999: Hauke Schmidt; K Stuertz; F Trostdorf; V Chen; I Sadowski; Wolfgang Brück; Roland Nau
Streptococcal meningitis: effect of CSF filtration on inflammation and neuronal damage.
Journal of neurology 1999;246(11):1063-8.
1999: Roland Nau; Julianne Behnke-Mursch
[Diagnosis and treatment of brain abscesses].
Therapeutische Umschau. Revue thérapeutique 1999;56(11):659-63.
1999: F Trostdorf; Wolfgang Brück; M Schmitz-Salue; K Stuertz; S J Hopkins; N van Rooijen; I Huitinga; Roland Nau
Reduction of meningeal macrophages does not decrease migration of granulocytes into the CSF and brain parenchyma in experimental pneumococcal meningitis.
Journal of neuroimmunology 1999;99(2):205-10.
1999: O Schneider; Uwe Michel; Gregor Zysk; O Dubuis; Roland Nau
Clinical outcome in pneumococcal meningitis correlates with CSF lipoteichoic acid concentrations.
Neurology 1999;53(7):1584-7.
1999: Roland Nau; Herbert Desel; C Lassek; Herbert Kolenda; Hilmar Prange
Entry of tromethamine into the cerebrospinal fluid of humans after cerebrovascular events.
Clinical pharmacology and therapeutics 1999;66(1):25-32.
1999: D Bahner; Johannes Meller; Michael Stiefel; Roland Nau
[Juvenile dermatomyositis--acute recidivism or sepsis?].
Der Nervenarzt 1999;70(6):547-51.
1999: Roland Nau; Andreas Wellmer; A Soto; K Koch; O Schneider; Hauke Schmidt; Joachim Gerber; Uwe Michel; Wolfgang Brück
Rifampin reduces early mortality in experimental Streptococcus pneumoniae meningitis.
The Journal of infectious diseases 1999;179(6):1557-60.
1999: Hauke Schmidt; K Stuertz; Wolfgang Brück; V Chen; Argyrios K Stringaris; FR Fischer; Roland Nau
Intravenous granulocyte colony-stimulating factor increases the release of tumour necrosis factor and interleukin-1beta into the cerebrospinal fluid, but does not inhibit the growth of Streptococcus pneumoniae in experimental meningitis.
Scandinavian journal of immunology 1999;49(5):481-6.
1999: Roland Nau; A Soto; Wolfgang Brück
Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis.
Journal of neuropathology and experimental neurology 1999;58(3):265-74.
1999: Maria Seipelt; Inga Zerr; Roland Nau; Brit Mollenhauer; Stefan Kropp; Bernhard J Steinhoff; C Wilhelm-Gössling; C Bamberg; R W Janzen; P Berlit; F Manz; K Felgenhauer; Sigrid Poser
Hashimoto's encephalitis as a differential diagnosis of Creutzfeldt-Jakob disease.
Journal of neurology, neurosurgery, and psychiatry 1999;66(2):172-6.
1999: K Stuertz; Hauke Schmidt; F Trostdorf; Helmut Eiffert; Michael Mäder; Roland Nau
Lower lipoteichoic and teichoic acid CSF concentrations during treatment of pneumococcal meningitis with non-bacteriolytic antibiotics than with ceftriaxone.
Scandinavian journal of infectious diseases 1999;31(4):367-70.
1999: F Trostdorf; Ralf Rene Reinert; Hauke Schmidt; T Nichterlein; K Stuertz; M Schmitz-Salue; I Sadowski; Wolfgang Brück; Roland Nau
Quinupristin/dalfopristin attenuates the inflammatory response and reduces the concentration of neuron-specific enolase in the cerebrospinal fluid of rabbits with experimental Streptococcus pneumoniae meningitis.
The Journal of antimicrobial chemotherapy 1999;43(1):87-94.
1998: Joachim Gerber; Hayrettin Tumani; Herbert Kolenda; Roland Nau
Lumbar and ventricular CSF protein, leukocytes, and lactate in suspected bacterial CNS infections.
Neurology 1998;51(6):1710-4.
1998: Hayrettin Tumani; Roland Nau; K Felgenhauer
Beta-trace protein in cerebrospinal fluid: a blood-CSF barrier-related evaluation in neurological diseases.
Annals of neurology 1998;44(6):882-9.
1998: Ivo Azeh; Michael Mäder; Alexandr Smirnov; Wolfgang Beuche; Roland Nau; Frank Weber
Experimental pneumococcal meningitis in rabbits: the increase of matrix metalloproteinase-9 in cerebrospinal fluid correlates with leucocyte invasion.
Neuroscience letters 1998;256(3):127-30.
1998: Roland Nau; Uwe K Zettl; Joachim Gerber; F Trostdorf; Uwe Michel; Tobias Böttcher; Hauke Schmidt; S Adler; Wolfgang Brück
Granulocytes in the subarachnoid space of humans and rabbits with bacterial meningitis undergo apoptosis and are eliminated by macrophages.
Acta neuropathologica 1998;96(5):472-80.
1998: Roland Nau; Fritz Sörgel; Hilmar Prange
Pharmacokinetic optimisation of the treatment of bacterial central nervous system infections.
Clinical pharmacokinetics 1998;35(3):223-46.
1998: Roland Nau; M Lantsch; Michael Stiefel; T Polak; Hansotto Reiber
Varicella zoster virus-associated focal vasculitis without herpes zoster: recovery after treatment with acyclovir.
Neurology 1998;51(3):914-5.
1998: Andreas Bitsch; Maria Seipelt; Hans-Heino Rustenbeck; Bernhard A Haug; Roland Nau
[MRI findings in Wernicke encephalopathy].
Der Nervenarzt 1998;69(8):707-11.
1998: Roland Nau; C Lassek; Martina Kinzig; A Thiel; Hilmar Prange; Fritz Sörgel
Disposition and elimination of meropenem in cerebrospinal fluid of hydrocephalic patients with external ventriculostomy.
Antimicrobial agents and chemotherapy 1998;42(8):2012-6.
1998: K Stuertz; I Merx; Helmut Eiffert; E Schmutzhard; Michael Mäder; Roland Nau
Enzyme immunoassay detecting teichoic and lipoteichoic acids versus cerebrospinal fluid culture and latex agglutination for diagnosis of Streptococcus pneumoniae meningitis.
Journal of clinical microbiology 1998;36(8):2346-8.
1998: Hauke Schmidt; A Dalhoff; K Stuertz; F Trostdorf; V Chen; O Schneider; C Kohlsdorfer; Wolfgang Brück; Roland Nau
Moxifloxacin in the therapy of experimental pneumococcal meningitis.
Antimicrobial agents and chemotherapy 1998;42(6):1397-407.
1998: Uwe Michel; Y Shintani; Roland Nau
Serum follistatin concentrations are increased in patients with septicaemia.
Clinical endocrinology 1998;48(4):413-7.
1998: Hayrettin Tumani; Hansotto Reiber; Roland Nau; Hilmar Prange; K Kauffmann; Michael Mäder; K Felgenhauer
Beta-trace protein concentration in cerebrospinal fluid is decreased in patients with bacterial meningitis.
Neuroscience letters 1998;242(1):5-8.
1998: K Stuertz; Hauke Schmidt; Helmut Eiffert; P Schwartz; Michael Mäder; Roland Nau
Differential release of lipoteichoic and teichoic acids from Streptococcus pneumoniae as a result of exposure to beta-lactam antibiotics, rifamycins, trovafloxacin, and quinupristin-dalfopristin.
Antimicrobial agents and chemotherapy 1998;42(2):277-81.
1998: Hauke Schmidt; K Stuertz; V Chen; Argyrios K Stringaris; Wolfgang Brück; Roland Nau
Glycerol does not reduce neuronal damage in experimental Streptococcus pneumoniae meningitis in rabbits.
Inflammopharmacology 1998;6(1):19-26.
1997: Andreas Bitsch; F Trostdorf; Wolfgang Brück; Hauke Schmidt; FR Fischer; Roland Nau
Central nervous system TNFalpha-mRNA expression during rabbit experimental pneumococcal meningitis.
Neuroscience letters 1997;237(2-3):105-8.
1997: Hauke Schmidt; Gregor Zysk; Ralf Rene Reinert; Wolfgang Brück; Argyrios K Stringaris; V Chen; K Stuertz; F Fischer; R Bartels; Klaus-Jürgen Schaper; S Weinig; Roland Nau
Rifabutin for experimental pneumococcal meningitis.
Chemotherapy 1997;43(4):264-71.
1997: Roland Nau; Gregor Zysk; Hauke Schmidt; FR Fischer; Argyrios K Stringaris; K Stuertz; Wolfgang Brück
Trovafloxacin delays the antibiotic-induced inflammatory response in experimental pneumococcal meningitis.
The Journal of antimicrobial chemotherapy 1997;39(6):781-8.
1997: Roland Nau; Martina Kinzig; Fritz Sörgel; S Schinschke; R Rössing; C Müller; Herbert Kolenda; Hilmar Prange
Kinetics of piperacillin and tazobactam in ventricular cerebrospinal fluid of hydrocephalic patients.
Antimicrobial agents and chemotherapy 1997;41(5):987-91.
1997: Hayrettin Tumani; A George; Roland Nau
[Myasthenic crisis caused by azathioprine-induced fever].
Der Nervenarzt 1997;68(4):336-8.
1997: Andreas Bitsch; Hilmar Prange; J Jansen; Roland Nau
[Frequent problems with antibiotic chemotherapy of bacterial CNS diseases. Case reports and recommendations for initial treatment].
Der Nervenarzt 1997;68(4):331-5.
1997: Argyrios K Stringaris; Wolfgang Brück; Hayrettin Tumani; Hauke Schmidt; Roland Nau
Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis.
Acta neuropathologica 1997;93(3):215-8.
1997: Gregor Zysk; Wolfgang Brück; FR Fischer; Michael Mäder; Peter Rieckmann; Roland Nau
Limited efficacy of pentoxifylline as anti-inflammatory agent in experimental pneumococcal meningitis.
Clinical and experimental immunology 1997;107(3):458-61.
1997: Gregor Zysk; Wolfgang Brück; I Huitinga; FR Fischer; F Flachsbarth; N van Rooijen; Roland Nau
Elimination of blood-derived macrophages inhibits the release of interleukin-1 and the entry of leukocytes into the cerebrospinal fluid in experimental pneumococcal meningitis.
Journal of neuroimmunology 1997;73(1-2):77-80.
1997: Roland Nau; Herbert Desel; C Lassek; A Thiel; S Schinschke; R Rössing; Herbert Kolenda; Hilmar Prange
Slow elimination of mannitol from human cerebrospinal fluid.
European journal of clinical pharmacology 1997;53(3-4):271-4.
1996: A Thiel; Roland Nau; F Fischer; H Meden; Karsten Harms; B Weissbrich; Hilmar Prange
Healthy infant delivered by a mother with subacute sclerosing panencephalitis during pregnancy.
Neurology 1996;47(6):1604.
1996: A Bitsch; Roland Nau; R A Hilgers; Raphaela Verheggen; G Werner; Hilmar Prange
Focal neurologic deficits in infective endocarditis and other septic diseases.
Acta neurologica Scandinavica 1996;94(4):279-86.
1996: Gregor Zysk; W Brück; Joachim Gerber; Y Brück; Hilmar Prange; Roland Nau
Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyrus in experimental pneumococcal meningitis.
Journal of neuropathology and experimental neurology 1996;55(6):722-8.
1996: Roland Nau; Hilmar Prange; Martina Kinzig; A Frank; A Dressel; P Scholz; Herbert Kolenda; Fritz Sörgel
Cerebrospinal fluid ceftazidime kinetics in patients with external ventriculostomies.
Antimicrobial agents and chemotherapy 1996;40(3):763-6.
1996: Roland Nau; Hilmar Prange
Estimation of steady state antibiotic concentration in cerebrospinal fluid from single-dose kinetics.
European journal of clinical pharmacology 1996;49(5):407-9.
1995: Roland Nau; Gregor Zysk; Ralf Rene Reinert; H Mergeryan; Helmut Eiffert; Hilmar Prange
Activity of fosfomycin in a rabbit model of experimental pneumococcal meningitis.
The Journal of antimicrobial chemotherapy 1995;36(6):997-1004.
1994: Roland Nau; Martina Kinzig; T Dreyhaupt; Herbert Kolenda; Fritz Sörgel; Hilmar Prange
Kinetics of ofloxacin and its metabolites in cerebrospinal fluid after a single intravenous infusion of 400 milligrams of ofloxacin.
Antimicrobial agents and chemotherapy 1994;38(8):1849-53.
1994: Gregor Zysk; Roland Nau; Hilmar Prange
[Bacterial CNS infections in adults in Southern Lower Saxony. A retrospective study of the Göttingen Neurologic University Clinic].
Der Nervenarzt 1994;65(8):527-35.
1994: Roland Nau; Fritz Sörgel; Hilmar Prange
Lipophilicity at pH 7.4 and molecular size govern the entry of the free serum fraction of drugs into the cerebrospinal fluid in humans with uninflamed meninges.
Journal of the neurological sciences 1994;122(1):61-5.
1993: Roland Nau; P Scholz; S Sharifi; S Rohde; Herbert Kolenda; Hilmar Prange
Netilmicin cerebrospinal fluid concentrations after an intravenous infusion of 400 mg in patients without meningeal inflammation.
The Journal of antimicrobial chemotherapy 1993;32(6):893-6.
1993: Roland Nau; Hilmar Prange; P Muth; Gerhard Mahr; S Menck; Herbert Kolenda; Fritz Sörgel
Passage of cefotaxime and ceftriaxone into cerebrospinal fluid of patients with uninflamed meninges.
Antimicrobial agents and chemotherapy 1993;37(7):1518-24.
1993: Roland Nau; D Emrich; Hilmar Prange
Inverse correlation between disappearance of intrathecally injected 111In-DTPA from CSF with CSF protein content and CSF-to-serum albumin ratio.
Journal of the neurological sciences 1993;115(1):102-4.
1993: Roland Nau; Gregor Zysk; A Thiel; Hilmar Prange
Pharmacokinetic quantification of the exchange of drugs between blood and cerebrospinal fluid in man.
European journal of clinical pharmacology 1993;45(5):469-75.
1992: Roland Nau; T Dreyhaupt; Herbert Kolenda; Hilmar Prange
Low blood-to-cerebrospinal fluid passage of sorbitol after intravenous infusion.
Stroke; a journal of cerebral circulation 1992;23(9):1276-9.
1992: Roland Nau; Hilmar Prange; S Menck; Herbert Kolenda; K Visser; J K Seydel
Penetration of rifampicin into the cerebrospinal fluid of adults with uninflamed meninges.
The Journal of antimicrobial chemotherapy 1992;29(6):719-24.
1992: Roland Nau; F J Prins; Herbert Kolenda; Hilmar Prange
Temporary reversal of serum to cerebrospinal fluid glycerol concentration gradient after intravenous infusion of glycerol.
European journal of clinical pharmacology 1992;42(2):181-5.
1992: Roland Nau; H W Prange; Jürgen Klingelhöfer; B Kukowski; Dirk Sander; R Tchorsch; K Rittmeyer
Results of four technical investigations in fifty clinically brain dead patients.
Intensive care medicine 1992;18(2):82-8.
1992: Roland Nau; Dirk Sander; Jürgen Klingelhöfer
Relationships between dopamine infusions and intracranial hemodynamics in patients with raised intracranial pressure.
Clinical neurology and neurosurgery 1992;94(2):143-8.
1990: Roland Nau; Hilmar Prange; J Martell; S Sharifi; Herbert Kolenda; J Bircher
Penetration of ciprofloxacin into the cerebrospinal fluid of patients with uninflamed meninges.
The Journal of antimicrobial chemotherapy 1990;25(6):965-73.
1990: Roland Nau; W Brück; E Bollensen; Hilmar Prange
Meningoencephalitis with septic intracerebral infarction: a new feature of CNS listeriosis.
Scandinavian journal of infectious diseases 1990;22(1):101-3.