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Christopher Navara

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Courtney M Creecy; Christopher S Navara; Christine F O'Neill; Victor L Sylvia; Bernard P Arulanandam; Rena Bizios
Mesenchymal stem cell osteodifferentiation in response to alternating electric current.
Annette R Rodriguez; Jieh-Juen Yu; Michael Berton; James P Chambers; Thomas G Forsthuber; M Neal Guentzel; Karl E Klose; Christopher S Navara; Bernard P Arulanandam
Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis.
Calvin Simerly; Dave McFarland; Carlos Castro; Chih-Cheng Lin; Carrie Redinger; Ethan Jacoby; Jocelyn Mich-Basso; Kyle E Orwig; Parker Mills; Eric T Ahrens; Christopher S Navara; Gerald Schatten
Interspecies chimera between primate embryonic stem cells and mouse embryos: monkey ESCs engraft into mouse embryos, but not post-implantation fetuses.

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All Publications

2013: Courtney M Creecy; Christopher S Navara; Christine F O'Neill; Victor L Sylvia; Bernard P Arulanandam; Rena Bizios
Mesenchymal stem cell osteodifferentiation in response to alternating electric current.
Tissue engineering. Part A 2013;19(3-4):467-74.
2012: Annette R Rodriguez; Jieh-Juen Yu; Michael Berton; James P Chambers; Thomas G Forsthuber; M Neal Guentzel; Karl E Klose; Christopher S Navara; Bernard P Arulanandam
Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(11):5604-11.
2011: Calvin Simerly; Dave McFarland; Carlos Castro; Chih-Cheng Lin; Carrie Redinger; Ethan Jacoby; Jocelyn Mich-Basso; Kyle E Orwig; Parker Mills; Eric T Ahrens; Christopher S Navara; Gerald Schatten
Interspecies chimera between primate embryonic stem cells and mouse embryos: monkey ESCs engraft into mouse embryos, but not post-implantation fetuses.
Stem cell research 2011;7(1):28-40.
2011: Olga Momčilović; Christopher S Navara; Gerald Schatten
Cell cycle adaptations and maintenance of genomic integrity in embryonic stem cells and induced pluripotent stem cells.
Results and problems in cell differentiation 2011;53():415-58.
2010: Dan Constantinescu; Antonei B Csoka; Christopher S Navara; Gerald Schatten
Defective DSB repair correlates with abnormal nuclear morphology and is improved with FTI treatment in Hutchinson-Gilford progeria syndrome fibroblasts.
Experimental cell research 2010;316(17):2747-59.
2010: Ahmi Ben-Yehudah; Christopher S Navara; Carrie J Redinger; Jocelyn D Mich-Basso; Carlos A Castro; Stacie Oliver; Lara J Chensny; Thomas J Richards; Naftali Kaminski; Gerald Schatten
Pluripotency genes overexpressed in primate embryonic stem cells are localized on homologues of human chromosomes 16, 17, 19, and X.
Stem cell research 2010;4(1):25-37.
2009: S Varum; O Momcilović; C Castro; A Ben-Yehudah; João Ramalho-Santos; Christopher S Navara
Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain.
Stem cell research 2009;3(2-3):142-56.
2009: Olga Momcilović; Serah Choi; Sandra Varum; Christopher J Bakkenist; Gerald Schatten; Christopher S Navara
Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells.
Stem cells (Dayton, Ohio) 2009;27(8):1822-35.
2009: Ahmi Ben-Yehudah; Carlie White; Christopher S Navara; Carlos A Castro; Diego Ize-Ludlow; Benjamin Shaffer; Meena Sukhwani; Clayton E Mathews; J Richard Chaillet; Selma F Witchel
Evaluating protocols for embryonic stem cell differentiation into insulin-secreting beta-cells using insulin II-GFP as a specific and noninvasive reporter.
Cloning and stem cells 2009;11(2):245-57.
2009: Calvin Simerly; Christopher S Navara; Carlos A Castro; Janet C Turpin; Carrie J Redinger; Jocelyn D Mich-Basso; Ethan S Jacoby; Kevin J Grund; David A McFarland; Stacie L Oliver; Ahmi Ben-Yehudah; Diane L Carlisle; Patricia Frost; Cecilia Penedo; Laura Hewitson; Gerald Schatten
Establishment and characterization of baboon embryonic stem cell lines: an Old World Primate model for regeneration and transplantation research.
Stem cell research 2009;2(3):178-87.
2008: M Cecilia Cirio; Sarayu Ratnam; Feng Ding; Brenda J Reinhart; Christopher S Navara; J Richard Chaillet
Preimplantation expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprints.
BMC developmental biology 2008;8():9.
2007: Christopher S Navara; Jocelyn D Mich-Basso; Carrie J Redinger; Ahmi Ben-Yehudah; Ethan Jacoby; Elizabeta Kovkarova-Naumovski; Meena Sukhwani; Kyle E Orwig; Naftali Kaminski; Carlos A Castro; Calvin Simerly; Gerald Schatten
Pedigreed primate embryonic stem cells express homogeneous familial gene profiles.
Stem cells (Dayton, Ohio) 2007;25(11):2695-704.
2007: Christopher S Navara; Carrie Redinger; Jocelyn Mich-Basso; Stacie Oliver; Ahmi Ben-Yehudah; Carlos Castro; Calvin Simerly
Derivation and characterization of nonhuman primate embryonic stem cells.
Current protocols in stem cell biology 2007;Chapter 1():Unit 1A.1.
2006: Justin C St John; Alexandra Amaral; Emma J Bowles; João Facucho Oliveira; Rhiannon Lloyd; Mariana Freitas; Heather L Gray; Christopher S Navara; Gisela Oliveira; Gerald Schatten; Emma C Spikings; João Ramalho-Santos
The analysis of mitochondria and mitochondrial DNA in human embryonic stem cells.
Methods in molecular biology (Clifton, N.J.) 2006;331():347-74.
2005: Ahmi Ben-Yehudah; Brenda J Reinhart; Christopher S Navara; Joyce Kotzuk; Selma F Witchel; Gerald Schatten; J Richard Chaillet
Specific dynamic and noninvasive labeling of pancreatic beta cells in reporter mice.
Genesis (New York, N.Y. : 2000) 2005;43(4):166-74.
2005: Gerald Schatten; Joseph Smith; Christopher S Navara; Jong-Hyuk Park; Roger Pedersen
Culture of human embryonic stem cells.
Nature methods 2005;2(6):455-63.
2005: Justin C St John; João Ramalho-Santos; Heather L Gray; Patti Petrosko; Vanesa Y Rawe; Christopher S Navara; Calvin Simerly; Gerald Schatten
The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells.
Cloning and stem cells 2005;7(3):141-53.
2004: Vanesa Y Rawe; Christopher Payne; Christopher S Navara; Gerald Schatten
WAVE1 intranuclear trafficking is essential for genomic and cytoskeletal dynamics during fertilization: cell-cycle-dependent shuttling between M-phase and interphase nuclei.
Developmental biology 2004;276(2):253-67.
2004: Calvin Simerly; Christopher S Navara; Sang Hwan Hyun; Byeong Chun Lee; Sung Keun Kang; Saverio Capuano; Gabriella G Gosman; Tanja Dominko; Kowit-Yu Chong; Duane A Compton; Woo Suk Hwang; Gerald Schatten
Embryogenesis and blastocyst development after somatic cell nuclear transfer in nonhuman primates: overcoming defects caused by meiotic spindle extraction.
Developmental biology 2004;276(2):237-52.
2004: Christopher S Navara
The spleen tyrosine kinase (Syk) in human disease, implications for design of tyrosine kinase inhibitor based therapy.
Current pharmaceutical design 2004;10(15):1739-44.
2003: Calvin Simerly; Tanja Dominko; Christopher S Navara; Christopher Payne; Saverio Capuano; Gabriella G Gosman; Kowit-Yu Chong; Diana Takahashi; Crista Chace; Duane A Compton; Laura Hewitson; Gerald Schatten
Molecular correlates of primate nuclear transfer failures.
Science (New York, N.Y.) 2003;300(5617):297.
2003: Calvin Simerly; Christopher S Navara
Nuclear transfer in the rhesus monkey: opportunities and challenges.
Cloning and stem cells 2003;5(4):319-31.
2002: Ravi Malaviya; Christopher S Navara; fatih uckun
Augmentation of mast cell bactericidal activity by the anti-leukemic drug, 4-(3'bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline.
Leukemia & lymphoma 2002;43(6):1329-32.
2002: Heather E Tibbles; Christopher S Navara; Michael A Hupke; Alexei O Vassilev; fatih uckun
Thrombopoietin induces p-selectin expression on platelets and subsequent platelet/leukocyte interactions.
Biochemical and biophysical research communications 2002;292(4):987-91.
2001: fatih uckun; C Mao; ST Jan; H Huang; Alexei O Vassilev; Christopher S Navara; Rama Krishna Narla
Spongistatins as tubulin targeting agents.
Current pharmaceutical design 2001;7(13):1291-6.
2001: Ravi Malaviya; Christopher S Navara; fatih uckun
Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria.
Immunity 2001;15(2):313-21.
2001: fatih uckun; N Pallisgaard; Peter Hokland; Christopher S Navara; Rama Krishna Narla; Paul S Gaynon; Harland Sather; Nyla A Heerema
Expression of TEL-AML1 fusion transcripts and response to induction therapy in standard risk acute lymphoblastic leukemia.
Leukemia & lymphoma 2001;42(1-2):41-56.
2001: fatih uckun; EA Sudbeck; C Mao; S Ghosh; Xing-Ping Liu; Alexei O Vassilev; Christopher S Navara; Rama Krishna Narla
Structure-based design of novel anticancer agents.
Current cancer drug targets 2001;1(1):59-71.
2001: R Krishna Narla; Christopher S Navara; MB Sarquis; fatih uckun
Chemosensitivity of TEL-AML1 fusion transcript positive acute lymphoblastic leukemia cells.
Leukemia & lymphoma 2001;41(5-6):615-23.
2001: P Ghosh; S Ghosh; Christopher S Navara; Rama Krishna Narla; Alexey Benyumov; fatih uckun
X-ray structure, solution properties, and biological activity profile of vanadocene(IV) acetylacetonate complex,.
Journal of inorganic biochemistry 2001;84(3-4):241-53.
2001: Christopher S Navara; Alexey Benyumov; Alexei O Vassilev; Rama Krishna Narla; P Ghosh; fatih uckun
Vanadocenes as potent anti-proliferative agents disrupting mitotic spindle formation in cancer cells.
Anti-cancer drugs 2001;12(4):369-76.
2000: Ravi Malaviya; C L Chen; Christopher S Navara; R Malaviya; XP Liu; M Keenan; B Waurzyniak; fatih uckun
Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97).
The Journal of pharmacology and experimental therapeutics 2000;295(3):912-26.
2000: fatih uckun; C Mao; ST Jan; H Huang; Alexei O Vassilev; EA Sudbeck; Christopher S Navara; Rama Krishna Narla
SPIKET and COBRA compounds as novel tubulin modulators with potent anticancer activity.
Current opinion in investigational drugs (London, England : 2000) 2000;1(2):252-6.
2000: ST Jan; C Mao; Alexei O Vassilev; Christopher S Navara; fatih uckun
COBRA-1, a rationally-designed epoxy-THF containing compound with potent tubulin depolymerizing activity as a novel anticancer agent.
Bioorganic & medicinal chemistry letters 2000;10(11):1193-7.
2000: fatih uckun; C Mao; Alexei O Vassilev; Christopher S Navara; Rama Krishna Narla; ST Jan
A rationally designed anticancer drug targeting a unique binding cavity of tubulin.
Bioorganic & medicinal chemistry letters 2000;10(10):1015-8.
2000: Rama Krishna Narla; Y Dong; Osmond J D'Cruz; Christopher S Navara; fatih uckun
Bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium(IV) as a novel apoptosis-inducing anticancer agent.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1546-56.
1999: L Sun; Patricia A Goodman; C M Wood; ML Crotty; Martha G Sensel; Harland Sather; Christopher S Navara; James B Nachman; Peter G Steinherz; Paul S Gaynon; Nita L Seibel; Alexei O Vassilev; B D Juran; Gregory H Reaman; fatih uckun
Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(12):3753-66.
1999: Calvin Simerly; S S Zoran; Christopher Payne; Tanja Dominko; Peter Sutovsky; Christopher S Navara; JL Salisbury; Gerald Schatten
Biparental inheritance of gamma-tubulin during human fertilization: molecular reconstitution of functional zygotic centrosomes in inseminated human oocytes and in cell-free extracts nucleated by human sperm.
Molecular biology of the cell 1999;10(9):2955-69.
1999: L Sun; ML Crotty; Martha G Sensel; Harland Sather; Christopher S Navara; James B Nachman; Peter G Steinherz; Paul S Gaynon; Nita L Seibel; C Mao; Alexei O Vassilev; Gregory H Reaman; fatih uckun
Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(8):2112-20.
1999: L Sun; N Heerema; L Crotty; X Wu; Christopher S Navara; Alexei O Vassilev; Martha G Sensel; Gregory H Reaman; fatih uckun
Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):680-5.
1999: Alexei O Vassilev; ZAHIDE OZER; Christopher S Navara; S Mahajan; fatih uckun
Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex.
The Journal of biological chemistry 1999;274(3):1646-56.
1999: CL Chen; Ravi Malaviya; Christopher S Navara; H Chen; B Bechard; G Mitcheltree; XP Liu; fatih uckun
Pharmacokinetics and biologic activity of the novel mast cell inhibitor, 4-(3-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in mice.
Pharmaceutical research 1999;16(1):117-22.
1998: S Ghosh; Y Zheng; X Jun; Rama Krishna Narla; S Mahajan; Christopher S Navara; C Mao; EA Sudbeck; fatih uckun
Alpha-cyano-beta-hydroxy-beta-methyl-N-[4-(trifluoromethoxy)phenyl] propenamide: an inhibitor of the epidermal growth factor receptor tyrosine kinase with potent cytotoxic activity against breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(11):2657-68.
1997: Peter Sutovsky; Mark W Tengowski; Christopher S Navara; S S Zoran; Gerald Schatten
Mitochondrial sheath movement and detachment in mammalian, but not nonmammalian, sperm induced by disulfide bond reduction.
Molecular reproduction and development 1997;47(1):79-86.
1997: Christopher S Navara; L C Hewitson; Calvin Simerly; Peter Sutovsky; Gerald Schatten
The implications of a paternally derived centrosome during human fertilization: consequences for reproduction and the treatment of male factor infertility.
American journal of reproductive immunology (New York, N.Y. : 1989) 1997;37(1):39-49.
1996: Peter Sutovsky; Christopher S Navara; Gerald Schatten
Fate of the sperm mitochondria, and the incorporation, conversion, and disassembly of the sperm tail structures during bovine fertilization.
Biology of reproduction 1996;55(6):1195-205.
1996: Peter Sutovsky; Laura Hewitson; Calvin Simerly; Mark W Tengowski; Christopher S Navara; A Haavisto; Gerald Schatten
Intracytoplasmic sperm injection for Rhesus monkey fertilization results in unusual chromatin, cytoskeletal, and membrane events, but eventually leads to pronuclear development and sperm aster assembly.
Human reproduction (Oxford, England) 1996;11(8):1703-12.
1996: Laura Hewitson; Calvin Simerly; Mark W Tengowski; Peter Sutovsky; Christopher S Navara; A J Haavisto; Gerald Schatten
Microtubule and chromatin configurations during rhesus intracytoplasmic sperm injection: successes and failures.
Biology of reproduction 1996;55(2):271-80.
1996: Christopher S Navara; N L First; Gerald Schatten
Phenotypic variations among paternal centrosomes expressed within the zygote as disparate microtubule lengths and sperm aster organization: correlations between centrosome activity and developmental success.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5384-8.
1995: Christopher S Navara; Calvin Simerly; Gerald Schatten
Imaging motility during fertilization.
Theriogenology 1995;44(8):1099-114.
1995: Christopher S Navara; G J Wu; Calvin Simerly; Gerald Schatten
Mammalian model systems for exploring cytoskeletal dynamics during fertilization.
Current topics in developmental biology 1995;31():321-42.
1995: Christopher S Navara; Calvin Simerly; S Zoran; Gerald Schatten
The sperm centrosome during fertilization in mammals: implications for fertility and reproduction.
Reproduction, fertility, and development 1995;7(4):747-54.
1995: Calvin Simerly; G J Wu; S Zoran; T Ord; RG Rawlins; J Jones; Christopher S Navara; M Gerrity; J Rinehart; Z Binor; R Asch; G Schatten
The paternal inheritance of the centrosome, the cell's microtubule-organizing center, in humans, and the implications for infertility.
Nature medicine 1995;1(1):47-52.
1994: William G Breed; Calvin Simerly; Christopher S Navara; John VandeBerg; Gerald Schatten
Microtubule configurations in oocytes, zygotes, and early embryos of a marsupial, Monodelphis domestica.
Developmental biology 1994;164(1):230-40.
1994: Christopher S Navara; Neal L First; Gerald Schatten
Microtubule organization in the cow during fertilization, polyspermy, parthenogenesis, and nuclear transfer: the role of the sperm aster.
Developmental biology 1994;162(1):29-40.