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Klaus-Armin Nave

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Georg L Wieser; Klaus-Armin Nave; Bartosz Adamcio; Benoit Barrette; Hannelore Ehrenreich; Ulrike C Gerwig; Sandra Goebbels
Neuroinflammation in white matter tracts of Cnp1 mutant mice amplified by a minor brain injury.
Michael R Vogl; Thomas Kosian; Melanie Küspert; Klaus-Armin Nave; S Reiprich; Heinrich Schrewe; Michael Wegner
Sox10 Cooperates with the Mediator Subunit 12 during Terminal Differentiation of Myelinating Glia.
Hauke B Werner; Patricia De Monasterio-Schrader; Ian R Griffiths; Eva-Maria Krämer-Albers; Wiebke Möbius; Tobias Moser; Yoshiko Ohno-Iwashita; Gesine Saher; Nicola Strenzke; Stefan Tenzer; Klaus-Armin Nave
A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.

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2013: Georg L Wieser; Klaus-Armin Nave; Bartosz Adamcio; Benoit Barrette; Hannelore Ehrenreich; Ulrike C Gerwig; Sandra Goebbels
Neuroinflammation in white matter tracts of Cnp1 mutant mice amplified by a minor brain injury.
Glia 2013;61(6):869-80.
2013: Michael R Vogl; Thomas Kosian; Melanie Küspert; Klaus-Armin Nave; S Reiprich; Heinrich Schrewe; Michael Wegner
Sox10 Cooperates with the Mediator Subunit 12 during Terminal Differentiation of Myelinating Glia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(15):6679-90.
2013: Hauke B Werner; Patricia De Monasterio-Schrader; Ian R Griffiths; Eva-Maria Krämer-Albers; Wiebke Möbius; Tobias Moser; Yoshiko Ohno-Iwashita; Gesine Saher; Nicola Strenzke; Stefan Tenzer; Klaus-Armin Nave
A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.
Glia 2013;61(4):567-86.
2013: Mostafa Bakhti; Matthias Eckhardt; Andreas Janshoff; Wiebke Möbius; Klaus-Armin Nave; David Schneider; Shweta Aggarwal; Nicolas Snaidero; Mikael Simons
Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):3143-8.
2013: Ingo Bormuth; Sandra Goebbels; Olga Grishina; Maike Gummert; Klaus-Armin Nave; Alexander Pieper; Victor Tarabykin; Sven Wichert; Kuo Yan; Tomoko Yonemasu; Mingyue Zhang; Weiqi Zhang; Markus H Schwab
Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(2):641-51.
2013: A El-Kordi; G Flügge; S Grube; C Hammer; Kurt Hammerschmidt; A Kästner; M Klugmann; Klaus-Armin Nave; J Patzig; R Pawlak; Swetlana Sperling; B Stepniak; Nicola Strenzke; H B Werner; M Begemann; P de Monasterio-Schrader; Hannelore Ehrenreich
A single gene defect causing claustrophobia.
Translational psychiatry 2013;3():e254.
2013: Ruth M Stassart; Viktorija Velanac; Markus H Schwab; Michael W Sereda; Bastian G Brinkmann; Robert Fledrich; Dies Meijer; Klaus-Armin Nave
A role for Schwann cell-derived neuregulin-1 in remyelination.
Nature neuroscience 2013;16(1):48-54.
2012: Gesine Saher; Karl-Friedrich Schmidt; Fabian Rudolphi; Torben Ruhwedel; Benoit Barrette; Kristina Corthals; Payam Dibaj; Siegrid Löwel; Wiebke Möbius; Klaus-Armin Nave
Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet.
Nature medicine 2012;18(7):1130-5.
2012: Amit Agarwal; Payam Dibaj; Sandra Goebbels; Celia M Kassmann; Klaus-Armin Nave; Markus H Schwab
In vivo imaging and noninvasive ablation of pyramidal neurons in adult NEX-CreERT2 mice.
Cerebral cortex (New York, N.Y. : 1991) 2012;22(7):1473-86.
2012: Inga H Deakin; David M Bannerman; Riam Kanso; Karri P Lamsa; Tracy Lane; Amanda J Law; Klaus-Armin Nave; Wiebke Nissen; Ole Paulsen; Markus H Schwab; Paul J Harrison
Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiation.
Cerebral cortex (New York, N.Y. : 1991) 2012;22(7):1520-9.
2012: Sandra Goebbels; Matthias Groszer; Tobias Nientiedt; Jan H Oltrogge; Alexander Pieper; Torben Ruhwedel; Michael W Sereda; Georg L Wieser; Susanne Wolfer; Klaus-Armin Nave
Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy.
EMBO molecular medicine 2012;4(6):486-99.
2012: Nora Hagemeyer; Stephan H Heckers; Sabine Hofer; Anne Kästner; Klaus-Armin Nave; Sergi Papiol; Anja Ronnenberg; Georg L Wieser; Jens Frahm; Ulrike C Gerwig; Sandra Goebbels; Artem Gurvich; Martin Begemann; Susann Boretius; Hannelore Ehrenreich
A myelin gene causative of a catatonia-depression syndrome upon aging.
EMBO molecular medicine 2012;4(6):528-39.
2012: Ursula Fünfschilling; Wolf J Jockusch; Younghoon Kim; Sai Li; Wiebke Möbius; Klaus-Armin Nave; Susanne Quintes; Jeong-Seop Rhee; Iwan A T Schaap; Nandhini Sivakumar; Kristina Corthals; Gesine Saher
Critical time window of neuronal cholesterol synthesis during neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(22):7632-45.
2012: Ursula Fünfschilling; Sandra Goebbels; Bernd Hamprecht; Celia M Kassmann; Don Mahad; Dies Meijer; Wiebke Möbius; Carlos T Moraes; Susann Boretius; Bastian G Brinkmann; Francisca Diaz; Julia Edgar; Jens Frahm; Aiman S Saab; Michael W Sereda; Lotti M Supplie; Ueli Suter; Iva D Tzvetanova; Klaus-Armin Nave
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.
Nature 2012;485(7399):517-21.
2012: Miki Furusho; Klaus-Armin Nave; Jeffrey L Dupree; Rashmi Bansal
Fibroblast growth factor receptor signaling in oligodendrocytes regulates myelin sheath thickness.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(19):6631-41.
2012: Diane L Sherman; Lai-Man N Wu; Yann-Gaël Gangloff; Matthew Grove; Michiel Krols; Klaus-Armin Nave; Peter J Brophy
Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(5):1817-25.
2012: Viktorija Velanac; Michael Willem; Carla Taveggia; Amelia Trimarco; Tilmann Unterbarnscheidt; Veronica Brivio; Tobias M Fischer; Maike N Gummert; Christian Haass; Wilko Hinrichs; Wiebke Möbius; Klaus-Armin Nave; Moritz Rossner; Markus H Schwab
Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination.
Glia 2012;60(2):203-17.
2012: Chi Wang Ip; Dennis Klein; Antje Kroner; Ricarda Diem; Julia M Edgar; Janos Groh; Marianne Huber; Klaus-Armin Nave; Irene Spahn; Sarah K Williams; Rudolf Martini
Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse.
PloS one 2012;7(8):e42554.
2012: Anne Kästner; Kamilla W Miskowiak; Klaus-Armin Nave; Anna Ramin; Dan Rujescu; Derya Sargin; Judith Schwitulla; Swetlana Sperling; Beata Stepniak; Ahmed El-Kordi; Heidi Friedrichs; Olaf Gefeller; Ina Giegling; Sabrina Grube; Kathrin Hannke; Ralf Heinrich; Martin Begemann; Hannelore Ehrenreich
Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia.
Molecular medicine (Cambridge, Mass.) 2012;18():1029-40.
2011: Ajit-Singh Dhaunchak; David R Colman; Klaus-Armin Nave
Misalignment of PLP/DM20 transmembrane domains determines protein misfolding in Pelizaeus-Merzbacher disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(42):14961-71.
2011: Damian Refojo; Marion Schumacher; Günther Schütz; Martin Schweizer; Inge Sillaber; Christoph K Thoeringer; Chadi Touma; Annette M Vogl; Gregor von Wolff; Carsten T Wotjak; Wolfgang Wurst; Matthias Eder; Stefanie Ehrenberg; David Engblom; Florian Holsboer; Claudia Kuehne; Klaus-Armin Nave; Charilaos Avrabos; Nina Dedic; Jan M Deussing
Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.
Science (New York, N.Y.) 2011;333(6051):1903-7.
2011: Celia M Kassmann; Wiebke Möbius; Myriam Baes; Tobias Nientiedt; Susanne Quintes; Jens Rietdorf; Gesine Saher; Michael Werner Sereda; Klaus-Armin Nave
A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.
FEBS letters 2011;585(14):2205-11.
2011: Sabrina Grube; Martin F Gerchen; Bartosz Adamcio; Luis A Pardo; Sabine Martin; Dörthe Malzahn; Sergi Papiol; Martin Begemann; Katja Ribbe; Heidi Friedrichs; Konstantin A Radyushkin; Michael Müller; Fritz Benseler; Joachim Riggert; Peter Falkai; Heike Bickeböller; Klaus-Armin Nave; Nils Brose; Walter Stühmer; Hannelore Ehrenreich
A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia.
EMBO molecular medicine 2011;3(6):309-19.
2011: Anke Feldmann; Jesa Amphornrat; Madeleine Schönherr; Christine Winterstein; Wiebke Möbius; Torben Ruhwedel; Lydia Danglot; Klaus-Armin Nave; Thierry Galli; Dieter Bruns; Jacqueline Trotter; Eva-Maria Krämer-Albers
Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(15):5659-72.
2011: Ying Chen; Haibo Wang; Sung Ok Yoon; Xiaomei Xu; Michael O Hottiger; John Svaren; Klaus-Armin Nave; Haesun A Kim; Eric N Olson; Q Richard Lu
HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination.
Nature neuroscience 2011;14(4):437-41.
2011: Sergi Papiol; Martin Begemann; Albert Rosenberger; Heidi Friedrichs; Katja Ribbe; Sabrina Grube; Markus H Schwab; Henriette Jahn; Stefan Gunkel; Fritz Benseler; Klaus-Armin Nave; Hannelore Ehrenreich
A phenotype-based genetic association study reveals the contribution of neuregulin1 gene variants to age of onset and positive symptom severity in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2011;156B(3):340-5.
2011: Roman Chrast; Gesine Saher; Klaus-Armin Nave; Mark H G Verheijen
Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models.
Journal of lipid research 2011;52(3):419-34.
2011: Gesine Saher; Susanne Quintes; Klaus-Armin Nave
Cholesterol: a novel regulatory role in myelin formation.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2011;17(1):79-93.
2011: Tanja Ducić; Susanne Quintes; Klaus-Armin Nave; Jean Susini; Margaret Rak; Rémi Tucoulou; Mihai Alevra; Peter Guttmann; Tim Salditt
Structure and composition of myelinated axons: a multimodal synchrotron spectro-microscopy study.
Journal of structural biology 2011;173(2):202-12.
2011: Hong Wang; Giuseppe Astarita; Matthew D Taussig; Kalyani G Bharadwaj; Nicholas V DiPatrizio; Klaus-Armin Nave; Daniele Piomelli; Ira J Goldberg; Robert H Eckel
Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity.
Cell metabolism 2011;13(1):105-13.
2011: Sergi Papiol; Swetlana Sperling; H Stefansson; M Begemann; Heike Bickeböller; A Kästner; D Malzahn; Klaus-Armin Nave; Hannelore Ehrenreich
Dissociation of accumulated genetic risk and disease severity in patients with schizophrenia.
Translational psychiatry 2011;1():e45.
2011: Derya Sargin; Swetlana Sperling; Sonja M Wojcik; Amit Agarwal; Ahmed El-Kordi; Imam Hassouna; Michael Müller; Klaus-Armin Nave; Hannelore Ehrenreich
Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice.
BMC biology 2011;9():27.
2010: Klaus-Armin Nave
Myelination and support of axonal integrity by glia.
Nature 2010;468(7321):244-52.
2010: Saadia A Karim; Jennifer A Barrie; Mailis C McCulloch; Paul Montague; Julia M Edgar; Debrah L Iden; Thomas J Anderson; Klaus-Armin Nave; Ian R Griffiths; Mark McLaughlin
PLP/DM20 expression and turnover in a transgenic mouse model of Pelizaeus-Merzbacher disease.
Glia 2010;58(14):1727-38.
2010: Astrid Bottelbergs; Simon Verheijden; Leen Hulshagen; David H Gutmann; Sandra Goebbels; Klaus-Armin Nave; Celia Kassmann; Myriam Baes
Axonal integrity in the absence of functional peroxisomes from projection neurons and astrocytes.
Glia 2010;58(13):1532-43.
2010: Jennifer A Barrie; Paul Montague; Saadia Karim; Douglas Kirkham; Klaus-Armin Nave; Thomas J Anderson; Ian R Griffiths; Mark McLaughlin
Modulation of rumpshaker phenotype with wild-type PLP/DM20 suggests several pathogenic mechanisms.
Journal of neuroscience research 2010;88(10):2135-45.
2010: Sandra Goebbels; Jan H Oltrogge; Robert Kemper; Ingo Heilmann; Ingo Bormuth; Susanne Wolfer; Sven P Wichert; Wiebke Möbius; Xin Liu; Corinna Lappe-Siefke; Moritz Rossner; Matthias Groszer; Ueli Suter; Jens Frahm; Susann Boretius; Klaus-Armin Nave
Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(26):8953-64.
2010: Chunyan Gu; Gretchen H Stein; Ning Pan; Sandra Goebbels; Hanna Hörnberg; Klaus-Armin Nave; Pedro Herrera; Peter White; Klaus H Kaestner; Lori Sussel; Jacqueline E Lee
Pancreatic beta cells require NeuroD to achieve and maintain functional maturity.
Cell metabolism 2010;11(4):298-310.
2010: Klaus-Armin Nave
Myelination and the trophic support of long axons.
Nature reviews. Neuroscience 2010;11(4):275-83.
2010: Klaus-Armin Nave
Oligodendrocytes and the "micro brake" of progenitor cell proliferation.
Neuron 2010;65(5):577-9.
2010: Susanne Quintes; Sandra Goebbels; Gesine Saher; Markus H Schwab; Klaus-Armin Nave
Neuron-glia signaling and the protection of axon function by Schwann cells.
Journal of the peripheral nervous system : JPNS 2010;15(1):10-6.
2010: Juliane Bremer; Frank Baumann; Cinzia Tiberi; Carsten Wessig; Heike Fischer; Petra Schwarz; Andrew D Steele; Klaus V Toyka; Klaus-Armin Nave; Joachim Weis; Adriano Aguzzi
Axonal prion protein is required for peripheral myelin maintenance.
Nature neuroscience 2010;13(3):310-8.
2010: Hiroshi Kawabe; Antje Neeb; Kalina Dimova; Samuel M Young; Michiko Takeda; Shutaro Katsurabayashi; Miso Mitkovski; Oxana A Malakhova; Dong-Er Zhang; Masato Umikawa; Ken-ichi Kariya; Sandra Goebbels; Klaus-Armin Nave; christian rosenmund; Olaf Jahn; JeongSeop Rhee; Nils Brose
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.
Neuron 2010;65(3):358-72.
2010: Julia M Edgar; Mailis C McCulloch; Paul Montague; Angus M Brown; Sebastian Thilemann; Laura Pratola; Fredrik I Gruenenfelder; Ian R Griffiths; Klaus-Armin Nave
Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease.
EMBO molecular medicine 2010;2(2):42-50.
2010: Antje Kroner; Chi Wang Ip; Johannes Thalhammer; Klaus-Armin Nave; Rudolf Martini
Ectopic T-cell specificity and absence of perforin and granzyme B alleviate neural damage in oligodendrocyte mutant mice.
The American journal of pathology 2010;176(2):549-55.
2010: Karolina Kolodziejczyk; Aiman S Saab; Klaus-Armin Nave; David Attwell
Why do oligodendrocyte lineage cells express glutamate receptors?
F1000 biology reports 2010;2():57.
2009: Julia M Edgar; Mark McLaughlin; Hauke B Werner; Mailis C McCulloch; Jennifer A Barrie; Angus Brown; Andrew Blyth Faichney; Nicolas Snaidero; Klaus-Armin Nave; Ian R Griffiths
Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1.
Glia 2009;57(16):1815-24.
2009: Inga H Deakin; Amanda J Law; Peter L Oliver; Markus H Schwab; Klaus-Armin Nave; Paul J Harrison; David M Bannerman
Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice.
Neuroreport 2009;20(17):1523-8.
2009: Anke Schardt; Bastian G Brinkmann; Miso Mitkovski; Michael W Sereda; Hauke B Werner; Klaus-Armin Nave
The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia.
Journal of neuroscience research 2009;87(15):3465-79.
2009: Eve Seuntjens; Anjana Nityanandam; Amaya Miquelajauregui; Joke Debruyn; Agata Stryjewska; Sandra Goebbels; Klaus-Armin Nave; Danny Huylebroeck; Victor Tarabykin
Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors.
Nature neuroscience 2009;12(11):1373-80.
2009: Gerardo Morfini; Matthew Burns; Lester I Binder; Nicholas M Kanaan; Nichole LaPointe; Daryl A Bosco; Robert H Brown; Hannah Brown; Ashutosh Tiwari; Lawrence Hayward; Julia Edgar; Klaus-Armin Nave; James Garberrn; Yuka Atagi; Yuyu Song; Gustavo Pigino; Scott T Brady
Axonal transport defects in neurodegenerative diseases.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(41):12776-86.
2009: Julia M Edgar; Klaus-Armin Nave
The role of CNS glia in preserving axon function.
Current opinion in neurobiology 2009;19(5):498-504.
2009: Alejandro Leal; Kathrin Huehne; Finn Bauer; Heinrich Sticht; Philipp Berger; Ueli Suter; Bernal Morera; Gerardo Del Valle; James R Lupski; Arif B Ekici; Francesca Pasutto; Sabine Endele; Ramiro Barrantes; Corinna Berghoff; Martin Berghoff; Bernhard Neundörfer; Dieter Heuss; Thomas Dorn; Peter Young; Lisa Santolin; Thomas Uhlmann; Michael Meisterernst; Michael Werner Sereda; Michael Sereda; Ruth Martha Stassart; Klaus-Armin Nave; André Reis; Gerd Meyer zu Horste; Bernd Rautenstrauss
Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models.
Neurogenetics 2009;10(4):275-87.
2009: Zhengliang Gao; Kerstin Ure; Jessica L Ables; Diane C Lagace; Klaus-Armin Nave; Sandra Goebbels; Amelia J Eisch; Jenny Hsieh
Neurod1 is essential for the survival and maturation of adult-born neurons.
Nature neuroscience 2009;12(9):1090-2.
2009: Antje Kroner; Nicholas Schwab; Chi Wang Ip; Sonja Ortler; Kerstin Göbel; Klaus-Armin Nave; Mathias Mäurer; Rudolf Martini; Heinz Wiendl
Accelerated course of experimental autoimmune encephalomyelitis in PD-1-deficient central nervous system myelin mutants.
The American journal of pathology 2009;174(6):2290-9.
2009: Kanako Saito; Veronique Dubreuil; Yoko Arai; Michaela Wilsch-Bräuninger; Dominik Schwudke; Gesine Saher; Takaki Miyata; Georg Breier; Christoph Thiele; Andrej Shevchenko; Klaus-Armin Nave; Wieland B Huttner
Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(20):8350-5.
2009: Gesine Saher; Susanne Quintes; Wiebke Möbius; Michael C Wehr; Eva-Maria Krämer-Albers; Britta Brügger; Klaus-Armin Nave
Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(19):6094-104.
2009: Schanila Nawaz; Angelika Kippert; Aiman S Saab; Hauke B Werner; Thorsten Lang; Klaus-Armin Nave; Mikael Simons
Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(15):4794-807.
2009: Sarah B Berman; Ying-bei Chen; Bing Qi; J Michael McCaffery; Edmund B Rucker; Sandra Goebbels; Klaus-Armin Nave; Beth A Arnold; Elizabeth A Jonas; Fernando Pineda; J Marie Hardwick
Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons.
The Journal of cell biology 2009;184(5):707-19.
2009: Maik Huttemann; Zhan Zhang; Chadwick Mullins; Denise Bessert; Icksoo Lee; Klaus-Armin Nave; Sunita Appikatla; Robert P Skoff
Different proteolipid protein mutants exhibit unique metabolic defects.
ASN neuro 2009;1(3):.
2009: Antje Kroner; Nicholas Schwab; Chi Wang Ip; Christoph Leder; Klaus-Armin Nave; Mathias Mäurer; Heinz Wiendl; Rudolf Martini
PD-1 regulates neural damage in oligodendroglia-induced inflammation.
PloS one 2009;4(2):e4405.
2009: Delphine Delaunay; Katharina Heydon; Andres Miguez; Markus Schwab; Klaus-Armin Nave; Jean-Léon Thomas; Nathalie Spassky; S Martinez; Bernard Zalc
Genetic tracing of subpopulation neurons in the prethalamus of mice (Mus musculus).
The Journal of comparative neurology 2009;512(1):74-83.
2008: Khalad Karram; Sandra Goebbels; Markus Schwab; Katja Jennissen; Gerald Seifert; Christian Steinhäuser; Klaus-Armin Nave; Jacqueline Trotter
NG2-expressing cells in the nervous system revealed by the NG2-EYFP-knockin mouse.
Genesis (New York, N.Y. : 2000) 2008;46(12):743-57.
2008: Carmen Birchmeier; Klaus-Armin Nave
Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation.
Glia 2008;56(14):1491-7.
2008: Dominique Bröhl; Michael Strehle; Hagen Wende; Kei Hori; Ingo Bormuth; Klaus-Armin Nave; Thomas Müller; Carmen Birchmeier
A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord.
Developmental biology 2008;322(2):381-93.
2008: Klaus-Armin Nave
Neuroscience: An ageing view of myelin repair.
Nature 2008;455(7212):478-9.
2008: Martin Begemann; Derya Sargin; Moritz Rossner; Claudia Bartels; Fabian Theis; Sven P Wichert; Nike Stender; Benjamin Fischer; Swetlana Sperling; Sabina Stawicki; Anne Wiedl; Peter Falkai; Klaus-Armin Nave; Hannelore Ehrenreich
Episode-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling supports novel treatment approaches.
Molecular medicine (Cambridge, Mass.) 2008;14(9-10):546-52.
2008: Bastian G Brinkmann; Amit Agarwal; Michael W Sereda; Alistair Garratt; Thomas Müller; Hagen Wende; Ruth M Stassart; Schanila Nawaz; Christian Humml; Viktorija Velanac; Konstantin Radyushkin; Sandra Goebbels; Tobias M Fischer; Robin J Franklin; Cary Lai; Hannelore Ehrenreich; Carmen Birchmeier; Markus H Schwab; Klaus-Armin Nave
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Neuron 2008;59(4):581-95.
2008: Chi Wang Ip; Bianca Kohl; Christoph Kleinschnitz; Bernhard Reuss; Klaus-Armin Nave; Antje Kroner; Rudolf Martini
Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve.
Molecular and cellular neurosciences 2008;38(4):489-94.
2008: Xinghua Yin; Grahame J Kidd; Klaus-Armin Nave; Bruce D Trapp
P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(28):7068-73.
2008: Celia Michèle Kassmann; Klaus-Armin Nave
Oligodendroglial impact on axonal function and survival - a hypothesis.
Current opinion in neurology 2008;21(3):235-41.
2008: Wiebke Möbius; Julia Patzig; Klaus-Armin Nave; Hauke B Werner
Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection.
Neuron glia biology 2008;4(2):111-27.
2008: Nivedita Chatterjee; Judith Stegmüller; Philipp Schätzle; Khalad Karram; Michael Koroll; Hauke B Werner; Klaus-Armin Nave; Jacqueline Trotter
Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells.
The Journal of biological chemistry 2008;283(13):8310-7.
2008: Delphine Delaunay; Katharina Heydon; Ana Cumano; Markus H Schwab; Jean-Léon Thomas; Ueli Suter; Klaus-Armin Nave; Bernard Zalc; Nathalie Spassky
Early neuronal and glial fate restriction of embryonic neural stem cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(10):2551-62.
2008: Moritz Rossner; Henrik Oster; Sven P Wichert; Lisa Reinecke; Michael C Wehr; Johannes Reinecke; Gregor Eichele; Reshma Taneja; Klaus-Armin Nave
Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice.
PloS one 2008;3(7):e2762.
2008: Klaus-Armin Nave; Bruce D Trapp
Axon-glial signaling and the glial support of axon function.
Annual review of neuroscience 2008;31():535-61.
2008: Bruce D Trapp; Klaus-Armin Nave
Multiple sclerosis: an immune or neurodegenerative disorder?
Annual review of neuroscience 2008;31():247-69.
2007: Richard Belvindrah; Diana Graus Porta; Sandra Goebbels; Klaus-Armin Nave; Ulrich Müller
Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(50):13854-65.
2007: Ajit-Singh Dhaunchak; Klaus-Armin Nave
A common mechanism of PLP/DM20 misfolding causes cysteine-mediated endoplasmic reticulum retention in oligodendrocytes and Pelizaeus-Merzbacher disease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17813-8.
2007: Eva-Maria Krämer-Albers; Niko Bretz; Stefan Tenzer; Christine Winterstein; Wiebke Möbius; Hendrik Berger; Klaus-Armin Nave; Hansjörg Schild; Jacqueline Trotter
Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Proteomics. Clinical applications 2007;1(11):1446-61.
2007: Christoph Leder; N Schwab; Chi Wang Ip; Antje Kroner; Klaus-Armin Nave; Klaus Dornmair; Rudolf Martini; Heinz Wiendl
Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice.
Molecular and cellular neurosciences 2007;36(3):416-24.
2007: Hannelore Ehrenreich; Benjamin Fischer; Christine Norra; Felix Schellenberger; Nike Stender; Michael Stiefel; Anna-Leena Sirén; Walter Paulus; Klaus-Armin Nave; Ralf Gold; Claudia Bartels
Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis.
Brain : a journal of neurology 2007;130(Pt 10):2577-88.
2007: Klaus-Armin Nave; Michael W Sereda; Hannelore Ehrenreich
Mechanisms of disease: inherited demyelinating neuropathies--from basic to clinical research.
Nature clinical practice. Neurology 2007;3(8):453-64.
2007: Celia M Kassmann; Corinna Lappe-Siefke; Myriam Baes; Britta Brügger; Alexander Mildner; Hauke B Werner; Oliver Natt; Thomas Michaelis; Marco Prinz; Jens Frahm; Klaus-Armin Nave
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes.
Nature genetics 2007;39(8):969-76.
2007: Ye He; Jeffrey L Dupree; Ju Wang; Juan Sandoval; Jiadong Li; Huifei Liu; Yang Shi; Klaus-Armin Nave; Patrizia Casaccia-Bonnefil
The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation.
Neuron 2007;55(2):217-30.
2007: Hauke B Werner; Katja Kuhlmann; Siming Shen; Marina Uecker; Anke Schardt; Kalina Dimova; Foteini Orfaniotou; Ajit-Singh Dhaunchak; Bastian G Brinkmann; Wiebke Möbius; Lenny Guarente; Patrizia Casaccia-Bonnefil; Olaf Jahn; Klaus-Armin Nave
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(29):7717-30.
2007: Yves Benninger; Tina Thurnherr; Jorge A Pereira; Sven Krause; Xunwei Wu; Anna Chrostek-Grashoff; Dominik Herzog; Klaus-Armin Nave; Robin J M Franklin; Dies Meijer; Cord Brakebusch; Ueli Suter; João B Relvas
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.
The Journal of cell biology 2007;177(6):1051-61.
2007: Martha Zeger; Gregory J Popken; Jihui Zhang; Shouhong Xuan; Q Richard Lu; Markus H Schwab; Klaus-Armin Nave; David H Rowitch; Augustine D'ercole; Ping Ye
Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination.
Glia 2007;55(4):400-11.
2007: Saadia A Karim; Jennifer A Barrie; Mailis C McCulloch; Paul Montague; Julia M Edgar; Douglas Kirkham; Thomas J Anderson; Klaus-Armin Nave; Ian R Griffiths; Mark McLaughlin
PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease.
Glia 2007;55(4):341-51.
2007: Matthew Grove; Noboru H Komiyama; Klaus-Armin Nave; Seth G N Grant; Diane L Sherman; Peter J Brophy
FAK is required for axonal sorting by Schwann cells.
The Journal of cell biology 2007;176(3):277-82.
2007: Gerd Meyer zu Horste; Thomas Prukop; David Liebetanz; Wiebke Mobius; Klaus-Armin Nave; Michael W Sereda
Antiprogesterone therapy uncouples axonal loss from demyelination in a transgenic rat model of CMT1A neuropathy.
Annals of neurology 2007;61(1):61-72.
2007: Ursula Fünfschilling; Gesine Saher; Le Xiao; Wiebke Möbius; Klaus-Armin Nave
Survival of adult neurons lacking cholesterol synthesis in vivo.
BMC neuroscience 2007;8():1.
2007: Chi Wang Ip; Antje Kroner; Paul R Crocker; Klaus-Armin Nave; Rudolf Martini
Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice.
Neurobiology of disease 2007;25(1):105-11.
2006: Sandra Goebbels; Ingo Bormuth; Ulli Bode; Ola Hermanson; Markus H Schwab; Klaus-Armin Nave
Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice.
Genesis (New York, N.Y. : 2000) 2006;44(12):611-21.
2006: Michael C Wehr; Rico Laage; Ulrike Bolz; Tobias M Fischer; Sylvia Grünewald; Sigrid Scheek; Alfred Bach; Klaus-Armin Nave; Moritz Rossner
Monitoring regulated protein-protein interactions using split TEV.
Nature methods 2006;3(12):985-93.
2006: Y Kaga; W J Shoemaker; M Furusho; M Bryant; J Rosenbluth; Steven E Pfeiffer; L Oh; Matthew N Rasband; Corinna Lappe-Siefke; K Yu; David M Ornitz; Klaus-Armin Nave; Rashmi Bansal
Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(47):12339-50.
2006: Eva-Maria Krämer-Albers; Katja Gehrig-Burger; Christoph Thiele; Jacqueline Trotter; Klaus-Armin Nave
Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(45):11743-52.
2006: Jochen H Weishaupt; Claudia Bartels; Esther Pölking; Jeannine Dietrich; Gundula Rohde; Burkhard Poeggeler; Nina Mertens; Swetlana Sperling; Matthias Bohn; Gerald Hüther; Armin Schneider; Alfred Bach; Anna-Leena Sirén; Rüdiger Hardeland; Mathias Bähr; Klaus-Armin Nave; Hannelore Ehrenreich
Reduced oxidative damage in ALS by high-dose enteral melatonin treatment.
Journal of pineal research 2006;41(4):313-23.
2006: Tina Thurnherr; Yves Benninger; Xunwei Wu; Anna Chrostek; Sven M Krause; Klaus-Armin Nave; Robin J M Franklin; Cord Brakebusch; Ueli Suter; João B Relvas
Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(40):10110-9.
2006: Gerd Meyer zu Hörste; Klaus-Armin Nave
Animal models of inherited neuropathies.
Current opinion in neurology 2006;19(5):464-73.
2006: Klaus-Armin Nave; James L Salzer
Axonal regulation of myelination by neuregulin 1.
Current opinion in neurobiology 2006;16(5):492-500.
2006: Moritz Rossner; Johannes Hirrlinger; Sven P Wichert; Christine Boehm; Dieter Newrzella; Holger Hiemisch; Gisela Eisenhardt; Carolin Stuenkel; Oliver von Ahsen; Klaus-Armin Nave
Global transcriptome analysis of genetically identified neurons in the adult cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(39):9956-66.
2006: Krisztina Monory; Federico Massa; Michaela Egertová; Matthias Eder; Heike Blaudzun; Ruth E Westenbroek; Wolfgang Kelsch; Wolfgang Jacob; Rudolf Marsch; Marc Ekker; Jason Long; John L Rubenstein; Sandra Goebbels; Klaus-Armin Nave; Matthew J During; Matthias Klugmann; Barbara Wölfel; Hans-Ulrich Dodt; Walter Zieglgänsberger; Carsten T Wotjak; Ken Mackie; Maurice R Elphick; Giovanni Marsicano; Beat Lutz
The endocannabinoid system controls key epileptogenic circuits in the hippocampus.
Neuron 2006;51(4):455-66.
2006: Jack Rosenbluth; Klaus-Armin Nave; Amanda Mierzwa; Rolf Schiff
Subtle myelin defects in PLP-null mice.
Glia 2006;54(3):172-82.
2006: Amir H Kashani; Zilong Qiu; Linda Jurata; Soo-Kyung Lee; Samuel Pfaff; Sandra Goebbels; Klaus-Armin Nave; Anirvan Ghosh
Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(32):8398-408.
2006: Chi Wang Ip; Antje Kroner; Martin Bendszus; Christoph Leder; Igor Kobsar; Stefan Fischer; Heinz Wiendl; Klaus-Armin Nave; Rudolf Martini
Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(31):8206-16.
2006: Yves Benninger; Holly Colognato; Tina Thurnherr; Robin J M Franklin; Dino P Leone; Suzana Atanasoski; Klaus-Armin Nave; Charles ffrench-Constant; Ueli Suter; João B Relvas
Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(29):7665-73.
2006: Jill H Fowler; Julia M Edgar; A Pringle; Mark McLaughlin; James McCulloch; Ian R Griffiths; James Y Garbern; Klaus-Armin Nave; Deborah Dewar
Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein.
Journal of neuroscience research 2006;84(1):68-77.
2006: Katarina Trajkovic; Ajit-Singh Dhaunchak; José T Goncalves; Dirk Wenzel; Anja Schneider; Gertrude Bunt; Klaus-Armin Nave; Mikael Simons
Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites.
The Journal of cell biology 2006;172(6):937-48.
2006: Lucilla Nobbio; Gianfranco Gherardi; Tiziana Vigo; Mario Passalacqua; Edon Melloni; Michele Abbruzzese; Gianluigi Mancardi; Klaus-Armin Nave; Angelo Schenone
Axonal damage and demyelination in long-term dorsal root ganglia cultures from a rat model of Charcot-Marie-Tooth type 1A disease.
The European journal of neuroscience 2006;23(6):1445-52.
2006: Xinghua Yin; Rena C Baek; Daniel A Kirschner; Alan Peterson; Yasuhisa Fujii; Klaus-Armin Nave; Wendy B Macklin; Bruce D Trapp
Evolution of a neuroprotective function of central nervous system myelin.
The Journal of cell biology 2006;172(3):469-78.
2006: Michael W Sereda; Klaus-Armin Nave
Animal models of Charcot-Marie-Tooth disease type 1A.
Neuromolecular medicine 2006;8(1-2):205-16.
2006: Gerd Meyer zu Hörste; Thomas Prukop; Klaus-Armin Nave; Michael W Sereda
Myelin disorders: Causes and perspectives of Charcot-Marie-Tooth neuropathy.
Journal of molecular neuroscience : MN 2006;28(1):77-88.
2006: Joern Schweitzer; Thomas Becker; Melitta Schachner; Klaus-Armin Nave; Hauke Werner
Evolution of myelin proteolipid proteins: gene duplication in teleosts and expression pattern divergence.
Molecular and cellular neurosciences 2006;31(1):161-77.
2005: Sheng-Xi Wu; Sandra Goebbels; Kazuhiro Nakamura; Kouichi Nakamura; Kohei Kometani; Nagahiro Minato; Takeshi Kaneko; Klaus-Armin Nave; Nobuaki Tamamaki
Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17172-7.
2005: Klaus-Armin Nave; Markus H Schwab
Glial cells under remote control.
Nature neuroscience 2005;8(11):1420-2.
2005: Sven Moosmang; Nicole Haider; Norbert Klugbauer; Helmuth Adelsberger; Nicolas Langwieser; Jochen Müller; Michael Stiess; Else Marais; Verena Schulla; Lubica Lacinova; Sandra Goebbels; Klaus-Armin Nave; Daniel R Storm; Franz Hofmann; Thomas Kleppisch
Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(43):9883-92.
2005: Tomoharu Osada; Nobuaki Tamamaki; Si-Young Song; Naoki Kakazu; Yukiko Yamazaki; Hatsune Makino; Ayako Sasaki; Teruyoshi Hirayama; Shun Hamada; Klaus-Armin Nave; Ryuzo Yanagimachi; Takeshi Yagi
Developmental pluripotency of the nuclei of neurons in the cerebral cortex of juvenile mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(37):8368-74.
2005: Sandra Goebbels; Ulli Bode; Alexander Pieper; Ursula Funfschilling; Markus H Schwab; Klaus-Armin Nave
Cre/loxP-mediated inactivation of the bHLH transcription factor gene NeuroD/BETA2.
Genesis (New York, N.Y. : 2000) 2005;42(4):247-52.
2005: Anja Schneider; Hanna Länder; Giselheid Schulz; Hartwig Wolburg; Klaus-Armin Nave; Jörg B Schulz; Mikael Simons
Palmitoylation is a sorting determinant for transport to the myelin membrane.
Journal of cell science 2005;118(Pt 11):2415-23.
2005: Tiziana Vigo; Lucilla Nobbio; Paul Van Hummelen; Michele Abbruzzese; Gianluigi Mancardi; Nathalie Verpoorten; Kristien Verhoeven; Michael W Sereda; Klaus-Armin Nave; Vincent Timmerman; Angelo Schenone
Experimental Charcot-Marie-Tooth type 1A: a cDNA microarrays analysis.
Molecular and cellular neurosciences 2005;28(4):703-14.
2005: Gesine Saher; Britta Brügger; Corinna Lappe-Siefke; Wiebke Möbius; Ryuichi Tozawa; Michael C Wehr; Felix T Wieland; Shun Ishibashi; Klaus-Armin Nave
High cholesterol level is essential for myelin membrane growth.
Nature neuroscience 2005;8(4):468-75.
2005: Matthew N Rasband; Jane Tayler; Yoshimi Kaga; Yang Yang; Corinna Lappe-Siefke; Klaus-Armin Nave; Rashmi Bansal
CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS.
Glia 2005;50(1):86-90.
2005: Hannelore Ehrenreich; Martin Hasselblatt; Friederike Knerlich; Nicolas Von Ahsen; Sonja Jacob; Swetlana Sperling; Helge Woldt; Katalin Vehmeyer; Klaus-Armin Nave; Anna-Leena Sirén
A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):862-7.
2004: Robert P Skoff; Denise Bessert; Mirela Cerghet; M J Franklin; Ujjwal K Rout; Klaus-Armin Nave; Leon R Carlock; M Said Ghandour; D Randall Armant
The myelin proteolipid protein gene modulates apoptosis in neural and non-neural tissues.
Cell death and differentiation 2004;11(12):1247-57.
2004: Andreas Ludwig; Beate Schlierf; Anke Schardt; Klaus-Armin Nave; Michael Wegner
Sox10-rtTA mouse line for tetracycline-inducible expression of transgenes in neural crest cells and oligodendrocytes.
Genesis (New York, N.Y. : 2000) 2004;40(3):171-5.
2004: Marina Grandis; Massimo Leandri; Tiziana Vigo; Michele Cilli; Michael W Sereda; Gianfranco Gherardi; Luana Benedetti; Gianluigi Mancardi; Michele Abbruzzese; Klaus-Armin Nave; Lucilla Nobbio; Angelo Schenone
Early abnormalities in sciatic nerve function and structure in a rat model of Charcot-Marie-Tooth type 1A disease.
Experimental neurology 2004;190(1):213-23.
2004: Damian Brockschnieder; Corinna Lappe-Siefke; Sandra Goebbels; Michael R Boesl; Klaus-Armin Nave; Dieter Riethmacher
Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination.
Molecular and cellular biology 2004;24(17):7636-42.
2004: Julia M Edgar; Mark McLaughlin; Donald A Yool; Su-Chun Zhang; Jill H Fowler; Paul Montague; Jennifer A Barrie; Mailis C McCulloch; Ian D Duncan; James Y Garbern; Klaus-Armin Nave; Ian R Griffiths
Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia.
The Journal of cell biology 2004;166(1):121-31.
2004: Galin V Michailov; Michael W Sereda; Bastian G Brinkmann; Tobias M Fischer; Bernhard Haug; Carmen Birchmeier; Lorna W Role; Cary Lai; Markus H Schwab; Klaus-Armin Nave
Axonal neuregulin-1 regulates myelin sheath thickness.
Science (New York, N.Y.) 2004;304(5671):700-3.
2003: Michael W Sereda; Gerd Meyer zu Hörste; Ueli Suter; Naureen Uzma; Klaus-Armin Nave
Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A).
Nature medicine 2003;9(12):1533-7.
2003: Hilary E Beggs; Dorreyah Schahin-Reed; Keling Zang; Sandra Goebbels; Klaus-Armin Nave; Jessica Gorski; Kevin R Jones; David W Sretavan; Louis F Reichardt
FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies.
Neuron 2003;40(3):501-14.
2003: Claus Rodemer; Thanh-Phuong Thai; Britta Brugger; Thomas Kaercher; Hauke Werner; Klaus-Armin Nave; Felix T Wieland; Karin Gorgas; Wilhelm W Just
Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice.
Human molecular genetics 2003;12(15):1881-95.
2003: Thomas Kleppisch; Wiebke Wolfsgruber; Susanne Feil; Rüdiger Allmann; Carsten T Wotjak; Sandra Goebbels; Klaus-Armin Nave; Franz Hofmann; Robert Feil
Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(14):6005-12.
2003: K Al-Saktawi; Mark McLaughlin; Matthias Klugmann; Armin Schneider; Jennifer A Barrie; Mailis C McCulloch; Paul Montague; Douglas Kirkham; Klaus-Armin Nave; Ian R Griffiths
Genetic background determines phenotypic severity of the Plp rumpshaker mutation.
Journal of neuroscience research 2003;72(1):12-24.
2003: Helga Jurevics; Janell Hostettler; Deanne W Sammond; Klaus-Armin Nave; Arrel D Toews; Pierre Morell
Normal metabolism but different physical properties of myelin from mice deficient in proteolipid protein.
Journal of neuroscience research 2003;71(6):826-34.
2003: Corinna Lappe-Siefke; Sandra Goebbels; Michel Gravel; Eva Nicksch; John Lee; Peter E Braun; Ian R Griffiths; Klaus-Armin Nave
Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination.
Nature genetics 2003;33(3):366-74.
2003: Judith Stegmüller; Hauke Werner; Klaus-Armin Nave; Jacqueline Trotter
The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling.
The Journal of biological chemistry 2003;278(6):3590-8.
2003: Annette Rünker; Udo Bartsch; Klaus-Armin Nave; Melitta Schachner
The C264Y missense mutation in the extracellular domain of L1 impairs protein trafficking in vitro and in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(1):277-86.
2002: Donald A Yool; Paul Montague; Mark McLaughlin; Mailis C McCulloch; Julia M Edgar; Klaus-Armin Nave; Roger Wayne Davies; Ian R Griffiths; Andy McCallion
Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform.
Glia 2002;39(3):256-67.
2002: Stephane Genoud; Corinna Lappe-Siefke; Sandra Goebbels; Freddy Radtke; Michel Aguet; Steven S Scherer; Ueli Suter; Klaus-Armin Nave; Ned Mantei
Notch1 control of oligodendrocyte differentiation in the spinal cord.
The Journal of cell biology 2002;158(4):709-18.
2002: Julia M Edgar; T James Anderson; P J Dickinson; Jennifer A Barrie; Mailis C McCulloch; Klaus-Armin Nave; Ian R Griffiths
Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene.
The Journal of cell biology 2002;158(4):719-29.
2002: Marcel Maier; Philipp Berger; Klaus-Armin Nave; Ueli Suter
Identification of the regulatory region of the peripheral myelin protein 22 (PMP22) gene that directs temporal and spatial expression in development and regeneration of peripheral nerves.
Molecular and cellular neurosciences 2002;20(1):93-109.
2002: Mikael Simons; Eva-Maria Kramer; Paolo Macchi; Silvia Rathke-Hartlieb; Jacqueline Trotter; Klaus-Armin Nave; Jörg B Schulz
Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease.
The Journal of cell biology 2002;157(2):327-36.
2002: James Y Garbern; Donald A Yool; Gregory Moore; Ian B Wilds; Michael W Faulk; Matthias Klugmann; Klaus-Armin Nave; Erik A Sistermans; Marjo S van der Knaap; Thomas D Bird; chris hall; John Kamholz; Ian R Griffiths
Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation.
Brain : a journal of neurology 2002;125(Pt 3):551-61.
2002: Suzana Atanasoski; Steven S Scherer; Klaus-Armin Nave; Ueli Suter
Proliferation of Schwann cells and regulation of cyclin D1 expression in an animal model of Charcot-Marie-Tooth disease type 1A.
Journal of neuroscience research 2002;67(4):443-9.
2002: Donald A Yool; Matthias Klugmann; Jennifer A Barrie; Mailis C McCulloch; Klaus-Armin Nave; Ian R Griffiths
Observations on the structure of myelin lacking the major proteolipid protein.
Neuropathology and applied neurobiology 2002;28(1):75-8.
2001: H Werner; L Dimou; Matthias Klugmann; S Pfeiffer; Klaus-Armin Nave
Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes.
Molecular and cellular neurosciences 2001;18(6):593-605.
2001: Mirela Cerghet; Denise Bessert; Klaus-Armin Nave; Robert P Skoff
Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways.
Journal of neurocytology 2001;30(9-10):841-55.
2001: Lucilla Nobbio; Gianluigi Mancardi; Marina Grandis; Giovanni Levi; U Suter; Klaus-Armin Nave; Anthony J Windebank; Michele Abbruzzese; Angelo Schenone
PMP22 transgenic dorsal root ganglia cultures show myelin abnormalities similar to those of human CMT1A.
Annals of neurology 2001;50(1):47-55.
2001: E M Krämer; Anke Schardt; Klaus-Armin Nave
Membrane traffic in myelinating oligodendrocytes.
Microscopy research and technique 2001;52(6):656-71.
2001: S Schneider; Frank Bosse; D D'Urso; H Muller; Michael W Sereda; Klaus-Armin Nave; A Niehaus; T Kempf; M Schnolzer; Jacqueline Trotter
The AN2 protein is a novel marker for the Schwann cell lineage expressed by immature and nonmyelinating Schwann cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(3):920-33.
2001: Donald A Yool; Matthias Klugmann; Mark McLaughlin; Demetrius A Vouyiouklis; L Dimou; Jennifer A Barrie; Mailis C McCulloch; Klaus-Armin Nave; Ian R Griffiths
Myelin proteolipid proteins promote the interaction of oligodendrocytes and axons.
Journal of neuroscience research 2001;63(2):151-64.
2001: Stefan Britsch; DE Goerich; Dieter Riethmacher; Reto I Peirano; Moritz Rossner; Klaus-Armin Nave; Carmen Birchmeier; Michael Wegner
The transcription factor Sox10 is a key regulator of peripheral glial development.
Genes & development 2001;15(1):66-78.
2000: S Niemann; Michael W Sereda; Ueli Suter; Ian R Griffiths; Klaus-Armin Nave
Uncoupling of myelin assembly and schwann cell differentiation by transgenic overexpression of peripheral myelin protein 22.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(11):4120-8.
2000: Markus H Schwab; A Bartholomae; B Heimrich; Dirk Feldmeyer; S Druffel-Augustin; Sandra Goebbels; F J Naya; S Zhao; M Frotscher; M J Tsai; Klaus-Armin Nave
Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(10):3714-24.
1999: S Niemann; Michael W Sereda; Moritz Rossner; H Stewart; Ueli Suter; H M Meinck; Ian R Griffiths; Klaus-Armin Nave
The "CMT rat": peripheral neuropathy and dysmyelination caused by transgenic overexpression of PMP22.
Annals of the New York Academy of Sciences 1999;883():254-61.
1999: Ueli Suter; Klaus-Armin Nave
Transgenic mouse models of CMT1A and HNPP.
Annals of the New York Academy of Sciences 1999;883():247-53.
1999: T James Anderson; Matthias Klugmann; Christine E Thomson; Armin Schneider; C Readhead; Klaus-Armin Nave; Ian R Griffiths
Distinct phenotypes associated with increasing dosage of the PLP gene: implications for CMT1A due to PMP22 gene duplication.
Annals of the New York Academy of Sciences 1999;883():234-46.
1999: Timotthy Coetzee; Koichi Suzuki; Klaus-Armin Nave; Brian Popko
Myelination in the absence of galactolipids and proteolipid proteins.
Molecular and cellular neurosciences 1999;14(1):41-51.
1999: L Dimou; Matthias Klugmann; H Werner; M Jung; Ian R Griffiths; Klaus-Armin Nave
Dysmyelination in mice and the proteolipid protein gene family.
Advances in experimental medicine and biology 1999;468():261-71.
1999: Paul Montague; Douglas Kirkham; Andy McCallion; Roger Wayne Davies; Peter G E Kennedy; Matthias Klugmann; Klaus-Armin Nave; Ian R Griffiths
Reduced levels of a specific myelin-associated oligodendrocytic basic protein isoform in shiverer myelin.
Developmental neuroscience 1999;21(1):36-42.
1998: S Niemann; Richard Sidman; Klaus-Armin Nave
Evidence against altered forms of MAG in the dysmyelinated mouse mutant claw paw.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(11):903-4.
1998: H Werner; M Jung; Matthias Klugmann; Michael W Sereda; Ian R Griffiths; Klaus-Armin Nave
Mouse models of myelin diseases.
Brain pathology (Zurich, Switzerland) 1998;8(4):771-93.
1998: Ian R Griffiths; Matthias Klugmann; T Anderson; Donald A Yool; Christine Thomson; Markus H Schwab; Armin Schneider; F Zimmermann; Mailis C McCulloch; N Nadon; Klaus-Armin Nave
Axonal swellings and degeneration in mice lacking the major proteolipid of myelin.
Science (New York, N.Y.) 1998;280(5369):1610-3.
1998: Ian R Griffiths; Matthias Klugmann; T Anderson; Christine Thomson; Demetrius A Vouyiouklis; Klaus-Armin Nave
Current concepts of PLP and its role in the nervous system.
Microscopy research and technique 1998;41(5):344-58.
1998: T James Anderson; Armin Schneider; Jennifer A Barrie; Matthias Klugmann; Mailis C McCulloch; Douglas Kirkham; E Kyriakides; Klaus-Armin Nave; Ian R Griffiths
Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene.
The Journal of comparative neurology 1998;394(4):506-19.
1998: Markus H Schwab; S Druffel-Augustin; Peter Gass; M Jung; Matthias Klugmann; A Bartholomae; Moritz Rossner; Klaus-Armin Nave
Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(4):1408-18.
1997: Sonja Forss-Petter; H Werner; Johannes Berger; H Lassmann; Brunhilde Molzer; Markus H Schwab; Hanno Bernheimer; F Zimmermann; Klaus-Armin Nave
Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice.
Journal of neuroscience research 1997;50(5):829-43.
1997: T James Anderson; Paul Montague; N Nadon; Klaus-Armin Nave; Ian R Griffiths
Modification of Schwann cell phenotype with Plp transgenes: evidence that the PLP and DM20 isoproteins are targeted to different cellular domains.
Journal of neuroscience research 1997;50(1):13-22.
1997: Christine E Thomson; Paul Montague; M Jung; Klaus-Armin Nave; Ian R Griffiths
Phenotypic severity of murine Plp mutants reflects in vivo and in vitro variations in transport of PLP isoproteins.
Glia 1997;20(4):322-32.
1997: Moritz Rossner; J Dörr; Peter Gass; Markus H Schwab; Klaus-Armin Nave
SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation.
Molecular and cellular neurosciences 1997;10(3-4):460-75.
1997: Moritz Rossner; J Dörr; Peter Gass; Markus H Schwab; Klaus-Armin Nave
SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation.
Molecular and cellular neurosciences 1997;9(5-6):460-75.
1997: Matthias Klugmann; Markus H Schwab; A Pühlhofer; Armin Schneider; F Zimmermann; Ian R Griffiths; Klaus-Armin Nave
Assembly of CNS myelin in the absence of proteolipid protein.
Neuron 1997;18(1):59-70.
1996: M Jung; I Sommer; M Schachner; Klaus-Armin Nave
Monoclonal antibody O10 defines a conformationally sensitive cell-surface epitope of proteolipid protein (PLP): evidence that PLP misfolding underlies dysmyelination in mutant mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(24):7920-9.
1996: Michael W Sereda; Ian R Griffiths; A Pühlhofer; H Stewart; Moritz Rossner; F Zimmerman; Josef Magyar; Armin Schneider; Ernst Hund; Hans-Michael Meinck; Ueli Suter; Klaus-Armin Nave
A transgenic rat model of Charcot-Marie-Tooth disease.
Neuron 1996;16(5):1049-60.
1995: Armin Schneider; Ian R Griffiths; C Readhead; Klaus-Armin Nave
Dominant-negative action of the jimpy mutation in mice complemented with an autosomal transgene for myelin proteolipid protein.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4447-51.
1994: A Bartholomä; Klaus-Armin Nave
NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons.
Mechanisms of development 1994;48(3):217-28.
1994: C Readhead; Armin Schneider; Ian R Griffiths; Klaus-Armin Nave
Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage.
Neuron 1994;12(3):583-95.
1993: ML Fanarraga; I U Sommer; Ian R Griffiths; Paul Montague; N P Groome; Klaus-Armin Nave; Armin Schneider; P J Brophy; Peter G E Kennedy
Oligodendrocyte development and differentiation in the rumpshaker mutation.
Glia 1993;9(2):146-56.
1992: Armin Schneider; Paul Montague; Ian R Griffiths; ML Fanarraga; P Kennedy; P Brophy; Klaus-Armin Nave
Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.
Nature 1992;358(6389):758-61.