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Alan Naylor

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Amanda C Allan; Andy Billinton; Susan H Brown; Anita Chowdhury; Andrew J Eatherton; Charlotte Fieldhouse; Gerard M P Giblin; Paul Goldsmith; Adrian Hall; David N Hurst; Alan Naylor; D Anthony Rawlings; Tiziana Scoccitti; Mairi Sime; Pamela J Theobald
Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists.
Brian Clarke; Leanne Cutler; Emmanuel Demont; Colin Dingwall; Rachel Dunsdon; Julie Hawkins; Colin Howes; Ishrut Hussain; Graham Maile; Rosalie Matico; Julie Mosley; Alan Naylor; Alistair O'Brien; Sally Redshaw; Paul Rowland; Virginie Soleil; Kathrine J Smith; Sharon Sweitzer; Pam Theobald; David Vesey; Daryl S Walter; Gareth Wayne
BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Adrian Hall; Richard L Elliott; Gerard M P Giblin; Ishrut Hussain; James Musgrave; Alan Naylor; Rosemary Sasse; Beverley Smith
Piperidine-derived gamma-secretase modulators.

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All Publications

2011: Amanda C Allan; Andy Billinton; Susan H Brown; Anita Chowdhury; Andrew J Eatherton; Charlotte Fieldhouse; Gerard M P Giblin; Paul Goldsmith; Adrian Hall; David N Hurst; Alan Naylor; D Anthony Rawlings; Tiziana Scoccitti; Mairi Sime; Pamela J Theobald
Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists.
Bioorganic & medicinal chemistry letters 2011;21(14):4343-8.
2010: Brian Clarke; Leanne Cutler; Emmanuel Demont; Colin Dingwall; Rachel Dunsdon; Julie Hawkins; Colin Howes; Ishrut Hussain; Graham Maile; Rosalie Matico; Julie Mosley; Alan Naylor; Alistair O'Brien; Sally Redshaw; Paul Rowland; Virginie Soleil; Kathrine J Smith; Sharon Sweitzer; Pam Theobald; David Vesey; Daryl S Walter; Gareth Wayne
BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Bioorganic & medicinal chemistry letters 2010;20(15):4639-44.
2010: Adrian Hall; Richard L Elliott; Gerard M P Giblin; Ishrut Hussain; James Musgrave; Alan Naylor; Rosemary Sasse; Beverley Smith
Piperidine-derived gamma-secretase modulators.
Bioorganic & medicinal chemistry letters 2010;20(3):1306-11.
2009: Gerard M P Giblin; Andrew Billinton; Michael Briggs; Andrew J Brown; Iain P Chessell; Nick M Clayton; Andrew J Eatherton; Paul Goldsmith; Carl Haslam; Matthew R Johnson; William L Mitchell; Alan Naylor; Alcide Perboni; Brian P Slingsby; Alex W Wilson
Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.
Journal of medicinal chemistry 2009;52(19):5785-8.
2009: Paul J Beswick; Andrew P Blackaby; Chas Bountra; Terry Brown; Kerry Browning; Ian B Campbell; John Corfield; Robert J Gleave; Steve B Guntrip; Richard M Hall; Sean Hindley; Paul F Lambeth; Fiona Lucas; Neil Mathews; Alan Naylor; Hazel Player; Helen S Price; Phillip J Sidebottom; Nicholas L Taylor; Graham Webb; Joanne Wiseman
Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.
Bioorganic & medicinal chemistry letters 2009;19(15):4509-14.
2009: Nicolas Charrier; Brian Clarke; Emmanuel Demont; Colin Dingwall; Rachel Dunsdon; Julie Hawkins; Julia Hubbard; Ishrut Hussain; Graham Maile; Rosalie Matico; Julie Mosley; Alan Naylor; Alistair O'Brien; Sally Redshaw; Paul Rowland; Virginie Soleil; Kathrine J Smith; Sharon Sweitzer; Pam Theobald; David Vesey; Daryl S Walter; Gareth Wayne
Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.
Bioorganic & medicinal chemistry letters 2009;19(13):3669-73.
2009: Nick Bailey; Mark J Bamford; Delphine Brissy; Joanna Brookfield; Emmanuel Demont; Richard Elliott; Neil Garton; Irene Farre-Gutierrez; Thomas Hayhow; Gail Hutley; Alan Naylor; Terry A Panchal; Hui-Xian Seow; David J Spalding; Andrew K Takle
Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).
Bioorganic & medicinal chemistry letters 2009;19(13):3602-6.
2009: Nicolas Charrier; Brian Clarke; Leanne Cutler; Emmanuel Demont; Colin Dingwall; Rachel Dunsdon; Julie Hawkins; Colin Howes; Julia Hubbard; Ishrut Hussain; Graham Maile; Rosalie Matico; Julie Mosley; Alan Naylor; Alistair O'Brien; Sally Redshaw; Paul Rowland; Virginie Soleil; Kathrine J Smith; Sharon Sweitzer; Pam Theobald; David Vesey; Daryl S Walter; Gareth Wayne
Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.
Bioorganic & medicinal chemistry letters 2009;19(13):3664-8.
2009: Nicolas Charrier; Brian Clarke; Leanne Cutler; Emmanuel Demont; Colin Dingwall; Rachel Dunsdon; Julie Hawkins; Colin Howes; Julia Hubbard; Ishrut Hussain; Graham Maile; Rosalie Matico; Julie Mosley; Alan Naylor; Alistair O'Brien; Sally Redshaw; Paul Rowland; Virginie Soleil; Kathrine J Smith; Sharon Sweitzer; Pam Theobald; David Vesey; Daryl S Walter; Gareth Wayne
Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.
Bioorganic & medicinal chemistry letters 2009;19(13):3674-8.
2009: Adrian Hall; Andy Billinton; Susan H Brown; Anita Chowdhury; Nicholas M Clayton; Gerard M P Giblin; Mairi Gibson; Paul A Goldsmith; David N Hurst; Alan Naylor; Caroline F Peet; Tiziana Scoccitti; Alexander W Wilson; Wendy Winchester
Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP(1) receptor antagonist for the treatment of inflammatory pain.
Bioorganic & medicinal chemistry letters 2009;19(9):2599-603.
2009: Adrian Hall; Susan H Brown; Christopher Budd; Nicholas M Clayton; Gerard M P Giblin; Paul Goldsmith; Thomas G Hayhow; David N Hurst; Alan Naylor; D Anthony Rawlings; Tiziana Scoccitti; Alexander W Wilson; Wendy J Winchester
Discovery of GSK345931A: An EP(1) receptor antagonist with efficacy in preclinical models of inflammatory pain.
Bioorganic & medicinal chemistry letters 2009;19(2):497-501.
2009: William L Mitchell; Gerard M P Giblin; Alan Naylor; Andrew J Eatherton; Brian P Slingsby; Anthony D Rawlings; Karamjit S Jandu; Carl P Haslam; Andrew J Brown; Paul Goldsmith; Nick M Clayton; Alex W Wilson; Iain P Chessell; Richard H Green; Andrew R Whittington; Ian D Wall
Pyridine-3-carboxamides as novel CB(2) agonists for analgesia.
Bioorganic & medicinal chemistry letters 2009;19(1):259-63.
2008: Andrew K Takle; Mark J Bamford; Susannah Davies; Robert P Davis; David K Dean; Alessandra Gaiba; Elaine A Irving; Frank D King; Alan Naylor; Christopher A Parr; Alison M Ray; Alastair D Reith; Beverley B Smith; Penelope C Staton; Jon G Steadman; Tania O Stean; David M Wilson
The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.
Bioorganic & medicinal chemistry letters 2008;18(15):4373-6.
2008: Nicolas Charrier; Brian Clarke; Leanne Cutler; Emmanuel Demont; Colin Dingwall; Rachel Dunsdon; Philip East; Julie Hawkins; Colin Howes; Ishrut Hussain; Phil Jeffrey; Graham Maile; Rosalie Matico; Julie Mosley; Alan Naylor; Alistair O'Brien; Sally Redshaw; Paul Rowland; Virginie Soleil; Kathrine J Smith; Sharon Sweitzer; Pam Theobald; David Vesey; Daryl S Walter; Gareth Wayne
Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.
Journal of medicinal chemistry 2008;51(11):3313-7.
2008: Brian Clarke; Emmanuel Demont; Colin Dingwall; Rachel Dunsdon; Andrew Faller; Julie Hawkins; Ishrut Hussain; David MacPherson; Graham Maile; Rosalie Matico; Peter Milner; Julie Mosley; Alan Naylor; Alistair O'Brien; Sally Redshaw; David Riddell; Paul Rowland; Virginie Soleil; Kathrine J Smith; Steven Stanway; Geoffrey Stemp; Sharon Sweitzer; Pam Theobald; David Vesey; Daryl S Walter; John Ward; Gareth Wayne
BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
Bioorganic & medicinal chemistry letters 2008;18(3):1011-6.
2008: Brian Clarke; Emmanuel Demont; Colin Dingwall; Rachel Dunsdon; Andrew Faller; Julie Hawkins; Ishrut Hussain; David MacPherson; Graham Maile; Rosalie Matico; Peter Milner; Julie Mosley; Alan Naylor; Alistair O'Brien; Sally Redshaw; David Riddell; Paul Rowland; Virginie Soleil; Kathrine J Smith; Steven Stanway; Geoffrey Stemp; Sharon Sweitzer; Pam Theobald; David Vesey; Daryl S Walter; John Ward; Gareth Wayne
BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
Bioorganic & medicinal chemistry letters 2008;18(3):1017-21.
2007: Adrian Hall; Susan H Brown; Anita Chowdhury; Gerard M P Giblin; Mairi Gibson; Mark P Healy; David G Livermore; Richard J Wilson; Alan Naylor; D Anthony Rawlings; Shilina Roman; Emma Ward; Caroline Willay
Identification and optimization of novel 1,3,4-oxadiazole EP1 receptor antagonists.
Bioorganic & medicinal chemistry letters 2007;17(16):4450-5.
2007: Gerard M P Giblin; Celestine T O'Shaughnessy; Alan Naylor; William L Mitchell; Andrew J Eatherton; Brian P Slingsby; D Anthony Rawlings; Paul Goldsmith; Andrew J Brown; Claudine Haslam; Nicholas M Clayton; Alex W Wilson; Iain P Chessell; Andrew R Wittington; Richard Green
Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain.
Journal of medicinal chemistry 2007;50(11):2597-600.
2007: Stephen C McKeown; Adrian Hall; Richard Blunt; Susan H Brown; Iain P Chessell; Anita Chowdhury; Gerard M P Giblin; Mark P Healy; Matthew R Johnson; Olivier Lorthioir; Anton D Michel; Alan Naylor; Xiao Q Lewell; Shilina Roman; Stephen P Watson; Wendy J Winchester; Richard J Wilson
Identification of novel glycine sulfonamide antagonists for the EP1 receptor.
Bioorganic & medicinal chemistry letters 2007;17(6):1750-4.
2007: Adrian Hall; Stephen Atkinson; Susan H Brown; Iain P Chessell; Anita Chowdhury; Gerard M P Giblin; Paul Goldsmith; Mark P Healy; Karamjit S Jandu; Matthew R Johnson; Anton D Michel; Alan Naylor; Jennifer Sweeting
Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists.
Bioorganic & medicinal chemistry letters 2007;17(5):1200-5.
2007: Adrian Hall; Susan H Brown; Iain P Chessell; Anita Chowdhury; Nicholas M Clayton; Tanya Coleman; Gerard M P Giblin; Beverley Hammond; Mark P Healy; Matthew R Johnson; Ann Metcalf; Anton D Michel; Alan Naylor; Riccardo Novelli; David J Spalding; Jennifer Sweeting; Lisa A Winyard
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists. Structure-activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives.
Bioorganic & medicinal chemistry letters 2007;17(4):916-20.
2007: Adrian Hall; Susan H Brown; Iain P Chessell; Anita Chowdhury; Nicholas M Clayton; Tanya Coleman; Gerard M P Giblin; Beverley Hammond; Mark P Healy; Matthew R Johnson; Ann Metcalf; Anton D Michel; Alan Naylor; Riccardo Novelli; David J Spalding; Jennifer Sweeting
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists: Structure-activity relationships of 4- and 5-substituted benzoic acid derivatives.
Bioorganic & medicinal chemistry letters 2007;17(3):732-5.
2007: Gerard M P Giblin; Rino A Bit; Susan H Brown; Helene Chaignot; Anita Chowdhury; Iain P Chessell; Nicholas M Clayton; Tanya Coleman; Adrian Hall; Beverley Hammond; David N Hurst; Anton D Michel; Alan Naylor; Riccardo Novelli; Tiziana Scoccitti; David J Spalding; Sac P Tang; Alex W Wilson; Rich Wilson
The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain.
Bioorganic & medicinal chemistry letters 2007;17(2):385-9.
2006: Jason Witherington; Emma L Blaney; Vincent Bordas; Richard L Elliott; Alessandra Gaiba; Neil Garton; Philip M Green; Alan Naylor; David G Smith; David J Spalding; Andrew K Takle; Robert W Ward
Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists.
Bioorganic & medicinal chemistry letters 2006;16(21):5538-41.
2006: Adrian Hall; Stephen Atkinson; Susan H Brown; Iain P Chessell; Anita Chowdhury; Nicholas M Clayton; Tanya Coleman; Gerard M P Giblin; Robert J Gleave; Beverley Hammond; Mark P Healy; Matthew R Johnson; Anton D Michel; Alan Naylor; Riccardo Novelli; David J Spalding; Sac P Tang
Structure-activity relationships of 1,5-biaryl pyrroles as EP1 receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(14):3657-62.
2006: Adrian Hall; Rino A Bit; Susan H Brown; Helene Chaignot; Iain P Chessell; Tanya Coleman; Gerard M P Giblin; David N Hurst; Ian R Kilford; Xiao Q Lewell; Anton D Michel; Shiyam Mohamed; Alan Naylor; Riccardo Novelli; Lee Skinner; David J Spalding; Sac P Tang; Richard J Wilson
Discovery of novel biaryl heterocyclic EP1 receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(10):2666-71.
2006: Jason Witherington; Vincent Bordas; Alessandra Gaiba; Phil M Green; Alan Naylor; Nigel Parr; David G Smith; Andrew K Takle; Robert W Ward
Pyridone derivatives as potent and selective VLA-4 integrin antagonists.
Bioorganic & medicinal chemistry letters 2006;16(8):2256-9.
2006: Andrew K Takle; Murray J B Brown; Susannah Davies; David K Dean; Gerraint Francis; Alessandra Gaiba; Alex W Hird; Frank D King; Peter J Lovell; Alan Naylor; Alastair D Reith; Jon G Steadman; David M Wilson
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
Bioorganic & medicinal chemistry letters 2006;16(2):378-81.
2006: Yiangos Yiangou; Paul Facer; Pascal F Durrenberger; Iain P Chessell; Alan Naylor; Chas Bountra; Richard R Banati; Praveen Anand
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.
BMC neurology 2006;6():12.
2005: Sharon Bingham; Paul J Beswick; Chas Bountra; Terry Brown; Ian B Campbell; Iain P Chessell; Nick Clayton; Sue D Collins; Philip T Davey; Helen Goodland; Norman Gray; Claudine Haslam; Jonathan P Hatcher; A Jackie Hunter; Fiona Lucas; Graham Murkitt; Alan Naylor; Elizabeth Pickup; Becky Sargent; Scott G Summerfield; Alexander Stevens; Sharon C Stratton; Joanne Wiseman
The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.
The Journal of pharmacology and experimental therapeutics 2005;312(3):1161-9.
2004: Paul J Beswick; Sharon Bingham; Chas Bountra; Terry Brown; Kerry Browning; Ian Campbell; Iain P Chessell; Nick Clayton; Sue Collins; John Corfield; Stephen Guntrip; Claudine Haslam; Paul Lambeth; Fiona Lucas; Neil Mathews; Graham Murkit; Alan Naylor; Neil Pegg; Elizabeth Pickup; Hazel Player; Helen Price; Alexander Stevens; Sharon Stratton; Joanne Wiseman
Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(21):5445-8.
2004: Pascal F Durrenberger; Paul Facer; Roy A Gray; Iain P Chessell; Alan Naylor; Chas Bountra; Richard B Banati; Rolfe Birch; Praveen Anand
Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury.
Journal of the peripheral nervous system : JPNS 2004;9(1):15-25.
2003: Jason Witherington; Vincent Bordas; Alessandra Gaiba; Alan Naylor; Anthony D Rawlings; Brian P Slingsby; David G Smith; Andrew K Takle; Robert W Ward
6-heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).
Bioorganic & medicinal chemistry letters 2003;13(18):3059-62.
2003: Jason Witherington; Vincent Bordas; Alessandra Gaiba; Neil S Garton; Alan Naylor; Anthony D Rawlings; Brian P Slingsby; David G Smith; Andrew K Takle; Robert W Ward
6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).
Bioorganic & medicinal chemistry letters 2003;13(18):3055-7.
1998: C L Branch; G Burton; G J Clarke; S Coulton; J D Douglas; A J Eglington; A W Guest; JD Hinks; N W Hird; R K Holland; E Hunt; S J Knott; S F Moss; Alan Naylor; MJ Pearson; Andrew K Takle
Novel C-2 substituted carbapenem derivatives. Part IV. Synthesis and biological activity of five membered heteroaromatic derivatives.
The Journal of antibiotics 1998;51(2):210-20.