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Thumbi Ndung'u

Research Profile

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HIV-1

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HIV Infections

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TOP 3
Andrew L Ferguson; Jaclyn K Mann; Thumbi Ndung'u; Saleha Omarjee; Bruce D Walker; Arup K Chakraborty
Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design.
Vivek Naranbhai; Thumbi Ndung'u; Marcus Altfeld; Quarraisha Abdool Karim; Salim S Abdool Karim; William H Carr
Changes in Natural Killer cell activation and function during primary HIV-1 Infection.
Denis R Chopera; Laura A Cotton; Debra de Assis Rosa; Clive Gray; Salim Abdool Karim; Jaclyn K Mann; Darren P Martin; Eric Martin; Toshiyuki Miura; Koleka Patience Mlisana; Thumbi Ndung'u; Nobubelo K Ngandu; Roman Ntale; Florencia Pereyra; Bruce D Walker; Carolyn Williamson; Zenda Woodman; Alexander Zawaira; Mark Alan Brockman; Zabrina L Brumme; Jonathan M Carlson
Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.

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All Publications

2013: Andrew L Ferguson; Jaclyn K Mann; Thumbi Ndung'u; Saleha Omarjee; Bruce D Walker; Arup K Chakraborty
Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design.
Immunity 2013;38(3):606-17.
2013: Vivek Naranbhai; Thumbi Ndung'u; Marcus Altfeld; Quarraisha Abdool Karim; Salim S Abdool Karim; William H Carr
Changes in Natural Killer cell activation and function during primary HIV-1 Infection.
PloS one 2013;8(1):e53251.
2012: Denis R Chopera; Laura A Cotton; Debra de Assis Rosa; Clive Gray; Salim Abdool Karim; Jaclyn K Mann; Darren P Martin; Eric Martin; Toshiyuki Miura; Koleka Patience Mlisana; Thumbi Ndung'u; Nobubelo K Ngandu; Roman Ntale; Florencia Pereyra; Bruce D Walker; Carolyn Williamson; Zenda Woodman; Alexander Zawaira; Mark Alan Brockman; Zabrina L Brumme; Jonathan M Carlson
Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.
Journal of virology 2012;86(24):13423-33.
2012: Derseree Archary; Saikat Boliar; Hoosen M Coovadia; Cynthia A Derdeyn; Anne-Sophie Dugast; Michelle L Gordon; Philip J R Goulder; Elin S Gray; Tandile Hermanus; Maphuti Madiga; Lynn Morris; Rong Rong; Lise Werner; Galit Alter; Thumbi Ndung'u
Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection.
Virology 2012;433(2):410-20.
2012: Henrik N Kløverpris; Alasdair J Leslie; Thumbi Ndung'u; Lynn Riddell; Dewald Steyn; Mary van der Stok; Cloete van Vuuren; Bruce D Walker; Søren Buus; Jonathan M Carlson; Mary Carrington; Fabian Chen; John Frater; Dominique Goedhals; Mikkel Harndahl; Kuan-Hsiang Gary Huang; Nasreen Ismail; Philip J R Goulder
HIV control through a single nucleotide on the HLA-B locus.
Journal of virology 2012;86(21):11493-500.
2012: Vivek Naranbhai; Thumbi Ndung'u; Quarraisha Abdool-Karim; Salim S Abdool-Karim; Marcus Altfeld; William H Carr
Natural killer cell function in women at high risk for HIV acquisition: insights from a microbicide trial.
AIDS (London, England) 2012;26(14):1745-53.
2012: Raabya Rossenkhan; TK Sebunya; Laura M Smeaton; Ibou Thior; Max Essex; Simani Gaseitsiwe; Jose E Hagan; Jean Leidner; Shahin Lockman; Joseph Makhema; Mompati Mmalane; sikhulile moyo; ROSEMARY MUSONDA; Thumbi Ndung'u; Vladimir Novitsky; Roger Shapiro
Infant feeding practices were not associated with breast milk HIV-1 RNA levels in a randomized clinical trial in Botswana.
AIDS and behavior 2012;16(5):1260-4.
2012: Thumbi Ndung'u; Robin A Weiss
On HIV diversity.
AIDS (London, England) 2012;26(10):1255-60.
2012: Thumbi Ndung'u
Resistance fighter. Interview by Brendan Borrell.
Scientific American 2012;306(6):80-3.
2012: Christina Thobakgale; Ildiko Toth; Bruce D Walker; Todd M Allen; Galit Alter; Suzane Bazner; Mary Carrington; Lena Fadda; Kimberly Lane; Thumbi Ndung'u; Florencia Pereyra; Eric S Rosenberg; Marcus Altfeld
Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection.
Journal of virology 2012;86(12):6986-93.
2012: Marianne W Mureithi; Vivek Naranbhai; Thumbi Ndung'u; Danielle Poole; Shabashini Reddy; Sengeziwe Sibeko; Lise Werner; Quarraisha Abdool-Karim; Salim Abdool Karim; Marcus Altfeld; Nompumelelo P Mkhwanazi
Preservation HIV-1-specific IFNγ+ CD4+ T-cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial.
Journal of acquired immune deficiency syndromes (1999) 2012;60(2):124-7.
2012: Jonathan M Carlson; John Frater; Philip J R Goulder; Carl Kadie; Jennifer Listgarten; Thumbi Ndung'u; Nico Pfeifer; Roger Shapiro; Vincent Tan; Bruce D Walker; Zabrina L Brumme; David Heckerman
Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.
Journal of virology 2012;86(9):5230-43.
2012: Taryn N Green; Anneke Grobler; Yolanda Lie; Elizabeth D Anton; Mohendran Archary; Raziya Bobat; Hoosen Coovadia; Michelle L Gordon; Nagavelli Padayachi; Jacqueline D Reeves; Thumbi Ndung'u
Drug resistance and coreceptor usage in HIV type 1 subtype C-infected children initiating or failing highly active antiretroviral therapy in South Africa.
AIDS research and human retroviruses 2012;28(4):324-32.
2012: Jaclyn K Wright; Jessica L Prince; Mark Alan Brockman; Zabrina L Brumme; Daniel T Claiborne; Philip J R Goulder; Eric Hunter; Vanessa L Naidoo; Thumbi Ndung'u
Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity.
Journal of virology 2012;86(6):3193-9.
2012: Philippa C Matthews; Zenele Mncube; Thumbi Ndung'u; Anthony Ogwu; Paolo Paioni; Rebecca Payne; Roger Shapiro; Dewald Steyn; Cloete van Vuuren; Bruce D Walker; Jonathan M Carlson; John Frater; Dominique Goedhals; David Heckerman; Kuan-Hsiang Gary Huang; Pieter Jooste; Jennifer Listgarten; Philip J R Goulder
Co-operative additive effects between HLA alleles in control of HIV-1.
PloS one 2012;7(10):e47799.
2012: Jessica E Mitchell; Thumbi Ndung'u; Mona Pillay; Bruce D Walker; Shivan Chetty; Pamla Govender; Manjeetha Jaggernath; Anne Kasmar; Paul Klenerman; Victoria O Kasprowicz
Prospective monitoring reveals dynamic levels of T cell immunity to Mycobacterium tuberculosis in HIV infected individuals.
PloS one 2012;7(6):e37920.
2011: Vanessa B Kerry; Patrick T Lee; Thumbi Ndung'u; Rochelle P Walensky; V Frederick I B Kayanja; David R Bangsberg
Managing the demand for global health education.
PLoS medicine 2011;8(11):e1001118.
2011: Vinod B Patel; Ravesh Singh; Cathy Connolly; Victoria Kasprowicz; Thumbi Ndung'u; Keertan Dheda
Comparative utility of cytokine levels and quantitative RD-1-specific T cell responses for rapid immunodiagnosis of tuberculous meningitis.
Journal of clinical microbiology 2011;49(11):3971-6.
2011: Ashika Singh; Henry Sunpath; Nagavelli Padayachi; Jacqueline D Reeves; Elizabeth D Anton; Taryn N Green; Keshni Hiramen; Daniel R Kuritzkes; Yolanda Lie; Richard Murphy; Thumbi Ndung'u
Drug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment options.
Journal of acquired immune deficiency syndromes (1999) 2011;58(3):233-40.
2011: Paradise Madlala; Koleka Patience Mlisana; Lise Werner; Cheryl A Winkler; Salim S Abdool-Karim; Ping An; Frauke Christ; zeger debyser; Rik Gijsbers; Anneleen Hombrouck; Thumbi Ndung'u
Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression.
AIDS (London, England) 2011;25(14):1711-9.
2011: Mopo Radebe; Mary van der Stok; Bruce D Walker; Jaclyn K Wright; Marcus Altfeld; Ingrid V Bassett; Karen Bishop; Fundisiwe Chonco; Zenele Mncube; Kriebashnie Nair; Thumbi Ndung'u
Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection.
The Journal of infectious diseases 2011;204(5):768-76.
2011: Christina Thobakgale; Gareth Tudor-Williams; Bruce D Walker; Andrew Prendergast; Hendrik Streeck; Marcus Altfeld; Fundisiwe Chonco; Philip J R Goulder; Lungile Maphumulo; Nompumelelo Mkhwanazi; Zenele Mncube; Thumbi Ndung'u
Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection.
AIDS research and human retroviruses 2011;27(9):1005-12.
2011: Vladimir Novitsky; Bruce D Walker; Rui Wang; Joseph Makhema; Thumbi Ndung'u; Hermann Bussmann; Fundisiwe Chonco; Victor De Gruttola; M Essex
Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection.
AIDS (London, England) 2011;25(12):1515-22.
2011: Thumbi Ndung'u
TRIM E3 ligases in HIV infection: can these intrinsic immunity factors be harnessed for novel vaccines or therapies?
Virulence 2011;2(4):360-6.
2011: Zaza M Ndhlovu; Thumbi Ndung'u; Alicja Piechocka-Trocha; Seanna Vine; Dan H Barouch; Philip J R Goulder; Kegakilwe C Koofhethile; Ashley McMullen; Bruce D Walker
Mosaic HIV-1 Gag antigens can be processed and presented to human HIV-specific CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(12):6914-24.
2011: Manju Mamtani; Srinivas Mummidi; Veron Ramsuran; Minh-Hieu Pham; Robert Maldonado; Kazi Begum; Maria Soledad Valera; Racquel Sanchez; JOHN ENRIQUE CASTIBLANCO; Hemant Kulkharni ; Thumbi Ndung'u; Weijing He; Juan-Manuel Anaya; Sunil Ahuja
Influence of variations in CCL3L1 and CCR5 on tuberculosis in a northwestern Colombian population.
The Journal of infectious diseases 2011;203(11):1590-4.
2011: W D Francois Venter; Thumbi Ndung'u; Quarraisha Abdool Karim
Case records of the Massachusetts General Hospital. Case 15-2011. A 19-year-old South African woman with headache, fatigue, and vaginal discharge.
The New England journal of medicine 2011;364(20):1956-64.
2011: Philippa C Matthews; Emily Adland; Jennifer Listgarten; Alasdair Leslie; Nompumelelo Mkhwanazi; Jonathan M Carlson; Mikkel Harndahl; Anette Stryhn; Rebecca P Payne; Anthony Ogwu; Kuan-Hsiang Gary Huang; John Frater; Paolo Paioni; Henrik Kloverpris; Pieter Jooste; Dominique Goedhals; Cloete van Vuuren; Dewald Steyn; Lynn Riddell; Fabian Chen; Graz Luzzi; Thambiah Balachandran; Thumbi Ndung'u; Soren Buus; Mary Carrington; Roger Shapiro; David Heckerman; Philip J R Goulder
HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(10):5675-86.
2011: Veron Ramsuran; Hemant Kulkharni ; Weijing He; Koleka Patience Mlisana; Edwina J Wright; Lise Werner; JOHN ENRIQUE CASTIBLANCO; Rahul Dhanda; Tuan Le; Matthew J Dolan; Weihua Guan; Robin A Weiss; Robert Clark; Sunil Ahuja; Salim S Abdool Karim; Thumbi Ndung'u
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011;52(10):1248-56.
2011: Marianne W Mureithi; Kristen Cohen; Ramona Moodley; Danielle Poole; Zenele Mncube; Anne Kasmar; D Branch Moody; Philip J R Goulder; Bruce D Walker; Marcus Altfeld; Thumbi Ndung'u
Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection.
AIDS research and human retroviruses 2011;27(5):501-9.
2011: Jaclyn K Wright; Vladimir Novitsky; Mark Alan Brockman; Zabrina L Brumme; Chanson J Brumme; Jonathan M Carlson; David Heckerman; Bingxia Wang; Elena Losina; Mopo Leshwedi; Mary van der Stok; Lungile Maphumulo; Nompumelelo Mkhwanazi; Fundisiwe Chonco; Philip J R Goulder; Max Essex; Bruce D Walker; Thumbi Ndung'u
Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.
Journal of virology 2011;85(8):3996-4006.
2011: Boris Julg; Eshia Moodley; Ying Qi; Danni Ramduth; Shabashini Reddy; Zenele Mncube; Xiaojiang Gao; Philip J R Goulder; Roger Detels; Thumbi Ndung'u; Bruce D Walker; Mary Carrington
Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.
The Journal of infectious diseases 2011;203(6):803-9.
2011: Vivek Naranbhai; Pat Bartman; Dudu Ndlovu; Pamela Ramkalawon; Thumbi Ndung'u; Douglas Wilson; Marcus Altfeld; William H Carr
Impact of blood processing variations on natural killer cell frequency, activation, chemokine receptor expression and function.
Journal of immunological methods 2011;366(1-2):28-35.
2011: Hayley Crawford; Philippa C Matthews; Malinda Schaefer; Jonathan M Carlson; Alasdair Leslie; William Kilembe; Susan Allen; Thumbi Ndung'u; David Heckerman; Eric Hunter; Philip J R Goulder
The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms.
Journal of virology 2011;85(3):1384-90.
2011: Victoria O Kasprowicz; Sebastian Brown; Shivan Chetty; Fundisiwe Chonco; Cheryl L Day; Helen A Fletcher; Pamla Govender; Kuan-Hsiang Gary Huang; Anne Kasmar; Ajit Lalvani; Cheryl McClurg; Kerry Millington; Jessica E Mitchell; Nompumelelo Mkhwanazi; Thumbi Ndung'u; Bruce D Walker; Daniel P Webster; Paul Klenerman
A molecular assay for sensitive detection of pathogen-specific T-cells.
PloS one 2011;6(8):e20606.
2011: Kuan-Hsiang Gary Huang; Dominique Goedhals; Jonathan M Carlson; Mark Alan Brockman; Swati Mishra; Zabrina L Brumme; Stephen Hickling; Christopher S W Tang; Toshiyuki Miura; Chris Seebregts; David Heckerman; Thumbi Ndung'u; Bruce Walker; Paul Klenerman; Dewald Steyn; Philip J R Goulder; Rodney Phillips; Cloete van Vuuren; John Frater
Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations.
PloS one 2011;6(4):e19018.
2011: Hannah O Ajoge; Michelle L Gordon; Tulio de Oliveira; Taryn N Green; Sani Ibrahim; Oladapo S Shittu; Stephen O Olonitola; Aliyu A Ahmad; Thumbi Ndung'u
Genetic characteristics, coreceptor usage potential and evolution of Nigerian HIV-1 subtype G and CRF02_AG isolates.
PloS one 2011;6(3):e17865.
2011: Malene Erup Larsen; Henrik Kloverpris; Anette Stryhn; Catherine K Koofhethile; Stuart Sims; Thumbi Ndung'u; Philip Goulder; Søren Buus; Morten Nielsen
HLArestrictor--a tool for patient-specific predictions of HLA restriction elements and optimal epitopes within peptides.
Immunogenetics 2011;63(1):43-55.
2011: Ravesh Singh; Gaurav Gaiha; Lise Werner; Kevin McKim; Koleka Patience Mlisana; Jeremy Luban; Bruce D Walker; Salim S Abdool Karim; Abraham L Brass; Thumbi Ndung'u
Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection.
Journal of virology 2011;85(1):208-16.
2010: Isobella Honeyborne; Francisco M Codoñer; Alasdair Leslie; Gareth Tudor-Williams; Graz Luzzi; Thumbi Ndung'u; Bruce D Walker; Philip J R Goulder; Julia G Prado
HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation.
Journal of virology 2010;84(21):11279-88.
2010: Jaclyn K Wright; Zabrina L Brumme; Jonathan M Carlson; David Heckerman; Carl M Kadie; Chanson J Brumme; Bingxia Wang; Elena Losina; Toshiyuki Miura; Fundisiwe Chonco; Mary van der Stok; Zenele Mncube; Karen Bishop; Philip J R Goulder; Bruce D Walker; Mark Alan Brockman; Thumbi Ndung'u
Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.
Journal of virology 2010;84(20):10820-31.
2010: Alasdair Leslie; Philippa C Matthews; Jennifer Listgarten; Jonathan M Carlson; Carl Kadie; Thumbi Ndung'u; Christian Brander; Hoosen Coovadia; Bruce D Walker; David Heckerman; Philip J R Goulder
Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.
Journal of virology 2010;84(19):9879-88.
2010: Nompumelelo Mkhwanazi; Christina Thobakgale; Mary van der Stok; Shabashini Reddy; Zenele Mncube; Fundisiwe Chonco; Bruce D Walker; Marcus Altfeld; Philip J R Goulder; Thumbi Ndung'u
Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.
Virology 2010;405(2):483-91.
2010: Vinod B Patel; Ravesh Singh; Cathy Connolly; yacoob coovadia; Abdool K C Peer; Priyashini Parag; Victoria Kasprowicz; Alimuddin Zumla; Thumbi Ndung'u; Keertan Dheda
Cerebrospinal T-cell responses aid in the diagnosis of tuberculous meningitis in a human immunodeficiency virus- and tuberculosis-endemic population.
American journal of respiratory and critical care medicine 2010;182(4):569-77.
2010: Marianne W Mureith; J Judy Chang; Jeffrey D Lifson; Thumbi Ndung'u; Marcus Altfeld
Exposure to HIV-1-encoded Toll-like receptor 8 ligands enhances monocyte response to microbial encoded Toll-like receptor 2/4 ligands.
AIDS (London, England) 2010;24(12):1841-8.
2010: Tammy M Meyers; Thumbi Ndung'u
Case records of the Massachusetts General Hospital. Case 18-2010. A 7-year-old boy with elevated HIV RNA levels despite antiretroviral medications.
The New England journal of medicine 2010;362(24):2305-12.
2010: B Julg; K L Williams; Sharon Reddy; Karen Bishop; Y Qi; M Carrington; Philip J R Goulder; Thumbi Ndung'u; Bruce D Walker
Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.
Journal of virology 2010;84(11):5540-9.
2010: Ambrose H W Wong; Katie Williams; Sharon Reddy; Douglas Wilson; Janet Giddy; Galit Alter; Musie Ghebremichael; Mary N Carrington; Thumbi Ndung'u; Bruce D Walker; Marcus Altfeld; William H Carr
Alterations in natural killer cell receptor profiles during HIV type 1 disease progression among chronically infected South African adults.
AIDS research and human retroviruses 2010;26(4):459-69.
2010: Anju Bansal; Jonathan Carlson; Jiyu Yan; Olusimidele T Akinsiku; Malinda Schaefer; Steffanie Sabbaj; Anne Bet; David N Levy; Sonya Heath; Jianming "James" Tang; Richard A Kaslow; Bruce D Walker; Thumbi Ndung'u; Philip J R Goulder; David Heckerman; Eric Hunter; Paul A Goepfert
CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription.
The Journal of experimental medicine 2010;207(1):51-9.
2010: Kavidha Reddy; Lise Werner; Cheryl A Winkler; Salim S Abdool-Karim; Koleka Patience Mlisana; Thumbi Ndung'u
APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral load.
AIDS (London, England) 2010;24(2):195-204.
2010: Derseree Archary; Michelle L Gordon; Taryn N Green; Hoosen M Coovadia; Philip J R Goulder; Thumbi Ndung'u
HIV-1 subtype C envelope characteristics associated with divergent rates of chronic disease progression.
Retrovirology 2010;7():92.
2010: Morgane Rolland; Jonathan M Carlson; Siriphan Manocheewa; J Victor Swain; Erinn Lanxon-Cookson; Wenjie Deng; Christine M Rousseau; Dana N Raugi; Gerald Learn; Brandon S Maust; Hoosen Coovadia; Thumbi Ndung'u; Philip J R Goulder; Bruce D Walker; Christian Brander; David E Heckerman; James I Mullins
Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
PloS one 2010;5(9):.
2010: Julia G Prado; Andrew Prendergast; Christina Thobakgale; Claudia Molina; Gareth Tudor-Williams; Thumbi Ndung'u; Bruce D Walker; Philip J R Goulder
Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate.
Journal of virology 2010;84(1):492-502.
2009: Raabya Rossenkhan; Thumbi Ndung'u; TK Sebunya; Jose E Hagan; Roger Shapiro; Vladimir Novitsky; sikhulile moyo; Ibou Thior; Shahin Lockman; Rebecca Mitchell; Soyeon Kim; ROSEMARY MUSONDA; Erik van Widenfelt; Joseph Makhema; Max Essex
Temporal reduction of HIV type 1 viral load in breast milk by single-dose nevirapine during prevention of MTCT.
AIDS research and human retroviruses 2009;25(12):1261-4.
2009: Nesri Padayatchi; E Stiefvater; K Naidoo; K Naidoo; Thumbi Ndung'u; Quarraisha Abdool-Karim
Expanding HIV surveillance to include TB patients in resource-limited settings with a generalized epidemic.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2009;13(12):1447-9.
2009: Ashika Singh; Taryn Page; Penny L Moore; Rachel L Allgaier; Keshni Hiramen; Hoosen M Coovadia; Bruce D Walker; Lynn Morris; Thumbi Ndung'u
Functional and genetic analysis of coreceptor usage by dualtropic HIV-1 subtype C isolates.
Virology 2009;393(1):56-67.
2009: Christina Thobakgale; Andrew Prendergast; Hayley Crawford; Nompumelelo Mkhwanazi; Danni Ramduth; Sharon Reddy; Claudia Molina; Zenele Mncube; Alasdair Leslie; Julia G Prado; Fundi Chonco; Wendy Mphatshwe; Gareth Tudor-Williams; Prakash Jeena; Natasha Blanckenberg; Krista Dong; Photini Kiepiela; Hoosen Coovadia; Thumbi Ndung'u; Bruce D Walker; Philip J R Goulder
Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.
Journal of virology 2009;83(19):10234-44.
2009: Zabrina Brumme; Bingxia Wang; Kriebashne Nair; Chanson Brumme; Chantal de Pierres; Shabashini Reddy; Boris Julg; Eshia Moodley; Christina Thobakgale; Zhigang Lu; Mary van der Stok; Karen Bishop; Zenele Mncube; Fundisiwe Chonco; Yuko Yuki; Nicole Frahm; Christian Brander; Mary Carrington; Kenneth Freedberg; Photini Kiepiela; Philip Goulder; Bruce Walker; Thumbi Ndung'u; Elena Losina
Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009;49(6):956-64.
2009: Dshanta D Naicker; Lise Werner; Emil Kormuth; Jo-Ann Passmore; Koleka Patience Mlisana; Salim Abdool Karim; Thumbi Ndung'u
Interleukin-10 promoter polymorphisms influence HIV-1 susceptibility and primary HIV-1 pathogenesis.
The Journal of infectious diseases 2009;200(3):448-52.
2009: Shamman Sewram; Ravesh Singh; Emil Kormuth; Lise Werner; Koleka Patience Mlisana; S S Abdool Karim; Thumbi Ndung'u
Human TRIM5alpha expression levels and reduced susceptibility to HIV-1 infection.
The Journal of infectious diseases 2009;199(11):1657-63.
2009: Boris Julg; Shabashini Reddy; Mary van der Stok; Smita Kulkarni; Ying Qi; Sara Bass; Bert Gold; Michael A Nalls; George W Nelson; Bruce D Walker; Mary Carrington; Thumbi Ndung'u
Lack of Duffy antigen receptor for chemokines: no influence on HIV disease progression in an African treatment-naive population.
Cell host & microbe 2009;5(5):413-5; author reply 418-9.
2009: Philippa C Matthews; Alasdair Leslie; Aris Katzourakis; Hayley Crawford; Rebecca Payne; Andrew Prendergast; Karen Power; Anthony D Kelleher; Paul Klenerman; Jonathan Carlson; David Heckerman; Thumbi Ndung'u; Bruce D Walker; Todd M Allen; Oliver G Pybus; Philip J R Goulder
HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering.
Journal of virology 2009;83(9):4605-15.
2009: Hayley Crawford; Wendy Lumm; Alasdair Leslie; Malinda Schaefer; Debrah Boeras; Julia G Prado; Jianming Tang; Paul Farmer; Thumbi Ndung'u; Shabir Lakhi; Jill Gilmour; Paul A Goepfert; Bruce D Walker; Richard A Kaslow; Joseph Mulenga; Susan Allen; Philip J R Goulder; Eric Hunter
Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients.
The Journal of experimental medicine 2009;206(4):909-21.
2009: Christine M Rousseau; David W Lockhart; Jennifer Listgarten; Stephen N Maley; Carl Kadie; Gerald Learn; David C Nickle; David E Heckerman; Wenjie Deng; Christian Brander; Thumbi Ndung'u; Hoosen Coovadia; Philip J R Goulder; Bette T Korber; Bruce D Walker; James I Mullins
Rare HLA drive additional HIV evolution compared to more frequent alleles.
AIDS research and human retroviruses 2009;25(3):297-303.
2009: Vinod B Patel; Ahmed I Bhigjee; Hoosain F Paruk; Ravesh Singh; Richard Meldau; Cathy Connolly; Thumbi Ndung'u; Keertan Dheda
Utility of a novel lipoarabinomannan assay for the diagnosis of tuberculous meningitis in a resource-poor high-HIV prevalence setting.
Cerebrospinal fluid research 2009;6():13.
2008: Philippa C Matthews; Andrew Prendergast; Alasdair Leslie; Hayley Crawford; Rebecca Payne; Christine M Rousseau; Morgane Rolland; Isobella Honeyborne; Jonathan Carlson; Carl Kadie; Christian Brander; Karen Bishop; Nonkululeko Mlotshwa; James I Mullins; Hoosen Coovadia; Thumbi Ndung'u; Bruce D Walker; David Heckerman; Philip J R Goulder
Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.
Journal of virology 2008;82(17):8548-59.
2008: Christine M Rousseau; Marcus G Daniels; Jonathan M Carlson; Carl Kadie; Hayley Crawford; Andrew Prendergast; Philippa Matthews; Rebecca Payne; Morgane Rolland; Dana N Raugi; Brandon S Maust; Gerald Learn; David C Nickle; Hoosen Coovadia; Thumbi Ndung'u; Nicole Frahm; Christian Brander; Bruce D Walker; Philip J R Goulder; Tanmoy Bhattacharya; David E Heckerman; Bette T Korber; James I Mullins
HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.
Journal of virology 2008;82(13):6434-46.
2007: Daisuke Watanabe; Mark Alan Brockman; Thumbi Ndung'u; Lydia Mathews; William Lucas; Cynthia G Murphy; Barbara K Felber; George Pavlakis; Neal A Deluca; David M Knipe
Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector.
Virology 2007;357(2):186-98.
2006: Roger L Shapiro; Ibou Thior; Peter B Gilbert; Shahin Lockman; C William Wester; Laura M Smeaton; Lisa Stevens; S Jody Heymann; Thumbi Ndung'u; Simani Gaseitsiwe; Vladimir Novitsky; Joseph Makhema; Stephen W Lagakos; Max Essex
Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana.
AIDS (London, England) 2006;20(9):1281-8.
2006: Vladimir Novitsky; Peter B Gilbert; Kimberly Shea; Mary Fran McLane; Natasha Rybak; Ilyana Klein; Ibou Thior; Thumbi Ndung'u; Tun-Hou Lee; Myron E Essex
Interactive association of proviral load and IFN-gamma-secreting T cell responses in HIV-1C infection.
Virology 2006;349(1):142-55.
2006: Thumbi Ndung'u; Enoch Sepako; Mary Fran McLane; Fatima Chand; Keabetswe Bedi; Simani Gaseitsiwe; Florence Doualla-Bell; Trevor Peter; Ibou Thior; sikhulile moyo; Peter B Gilbert; Vladimir Novitsky; Max Essex
HIV-1 subtype C in vitro growth and coreceptor utilization.
Virology 2006;347(2):247-60.
2005: Thumbi Ndung'u; Simani Gaseitsiwe; Enoch Sepako; Florence Doualla-Bell; Trevor Peter; Soyeon Kim; Ibou Thior; Vladimir Novitsky; Max Essex
Major histocompatibility complex class II (HLA-DRB and -DQB) allele frequencies in Botswana: association with human immunodeficiency virus type 1 infection.
Clinical and diagnostic laboratory immunology 2005;12(9):1020-8.
2005: Roger L Shapiro; Thumbi Ndung'u; Shahin Lockman; Laura M Smeaton; Ibou Thior; C William Wester; Lisa Stevens; Gaseene Sebetso; Simani Gaseitsiwe; Trevor Peter; Max Essex
Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk.
The Journal of infectious diseases 2005;192(5):713-9.
2003: Vladimir Novitsky; Peter Gilbert; Trevor Peter; Mary Fran McLane; Sarah M Gaolekwe; Natasha Rybak; Ibou Thior; Thumbi Ndung'u; Richard Marlink; Tun-Hou Lee; Max Essex
Association between virus-specific T-cell responses and plasma viral load in human immunodeficiency virus type 1 subtype C infection.
Journal of virology 2003;77(2):882-90.
2002: Vladimir Novitsky; Huyen Cao; Natasha Rybak; Peter Gilbert; Mary Fran McLane; Sarah M Gaolekwe; Trevor Peter; Ibou Thior; Thumbi Ndung'u; Richard Marlink; Tun-Hou Lee; Max Essex
Magnitude and frequency of cytotoxic T-lymphocyte responses: identification of immunodominant regions of human immunodeficiency virus type 1 subtype C.
Journal of virology 2002;76(20):10155-68.
2002: Vladimir Novitsky; U R Smith; Peter Gilbert; Mary Fran McLane; P Chigwedere; C Williamson; Thumbi Ndung'u; Ilyana Klein; Su-Yuan Chang; Trevor Peter; Ibou Thior; Brian Foley; Sarah M Gaolekwe; Natasha Rybak; Simani Gaseitsiwe; F Vannberg; Richard Marlink; Tun-Hou Lee; Max Essex
Human immunodeficiency virus type 1 subtype C molecular phylogeny: consensus sequence for an AIDS vaccine design?
Journal of virology 2002;76(11):5435-51.
2001: Thumbi Ndung'u; Yichen Lu; Boris Renjifo; Neal Touzjian; Nicholas Kushner; V Pena-Cruz; Vladimir Novitsky; Tun-Hou Lee; Max Essex
Infectious simian/human immunodeficiency virus with human immunodeficiency virus type 1 subtype C from an African isolate: rhesus macaque model.
Journal of virology 2001;75(23):11417-25.
2001: Vladimir Novitsky; Natasha Rybak; Mary Fran McLane; Peter Gilbert; P Chigwedere; Ilyana Klein; Sarah M Gaolekwe; Su-Yuan Chang; Trevor Peter; Ibou Thior; Thumbi Ndung'u; F Vannberg; Brian Foley; Richard Marlink; Tun-Hou Lee; Max Essex
Identification of human immunodeficiency virus type 1 subtype C Gag-, Tat-, Rev-, and Nef-specific elispot-based cytotoxic T-lymphocyte responses for AIDS vaccine design.
Journal of virology 2001;75(19):9210-28.
2001: Thumbi Ndung'u; Boris Renjifo; Max Essex
Construction and analysis of an infectious human Immunodeficiency virus type 1 subtype C molecular clone.
Journal of virology 2001;75(11):4964-72.
2001: Irene Koulinska; Thumbi Ndung'u; Davis Mwakagile; Gernard Msamanga; C Kagoma; Wafaie Fawzi; Max Essex; Boris Renjifo
A new human immunodeficiency virus type 1 circulating recombinant form from Tanzania.
AIDS research and human retroviruses 2001;17(5):423-31.
2000: Thumbi Ndung'u; Boris Renjifo; Vladimir Novitsky; Mary Fran McLane; Sarah M Gaolekwe; Max Essex
Molecular cloning and biological characterization of full-length HIV-1 subtype C from Botswana.
Virology 2000;278(2):390-9.
2000: Vladimir Novitsky; Sarah M Gaolekwe; Mary Fran McLane; Thumbi Ndung'u; Brian Foley; F Vannberg; Richard Marlink; Max Essex
HIV type 1 A/J recombinant with a pronounced pol gene mosaicism.
AIDS research and human retroviruses 2000;16(10):1015-20.
2000: Monty Montano; C P Nixon; Thumbi Ndung'u; Hermann Bussmann; Vladimir Novitsky; D Dickman; Max Essex
Elevated tumor necrosis factor-alpha activation of human immunodeficiency virus type 1 subtype C in Southern Africa is associated with an NF-kappaB enhancer gain-of-function.
The Journal of infectious diseases 2000;181(1):76-81.
1999: Vladimir Novitsky; Monty Montano; Mary Fran McLane; Boris Renjifo; F Vannberg; Brian Foley; Thumbi Ndung'u; M Rahman; M J Makhema; Richard Marlink; Max Essex
Molecular cloning and phylogenetic analysis of human immunodeficiency virus type 1 subtype C: a set of 23 full-length clones from Botswana.
Journal of virology 1999;73(5):4427-32.