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Daniel Nebert

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Marina Gálvez-Peralta; Marian L Miller; Jing Chen; Zhanquan Shi; Daniel W Nebert
Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct.
Ming-Jie Liu; Daniel W Nebert; Ryan E Pavlovicz; Charlie J Pyle; Andrew C Rudawsky; Mark D Wewers; Shengying Bao; Marina Gálvez-Peralta; David W Killilea; Chenglong Li; Daren L Knoell
ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB.
Daniel W Nebert; Kjell Wikvall; Walter L Miller
Human cytochromes P450 in health and disease.

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All Publications

2013: Marina Gálvez-Peralta; Marian L Miller; Jing Chen; Zhanquan Shi; Daniel W Nebert
Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct.
International journal of cancer. Journal international du cancer 2013;132(9):2065-75.
2013: Ming-Jie Liu; Daniel W Nebert; Ryan E Pavlovicz; Charlie J Pyle; Andrew C Rudawsky; Mark D Wewers; Shengying Bao; Marina Gálvez-Peralta; David W Killilea; Chenglong Li; Daren L Knoell
ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB.
Cell reports 2013;3(2):386-400.
2013: Daniel W Nebert; Kjell Wikvall; Walter L Miller
Human cytochromes P450 in health and disease.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013;368(1612):20120431.
2013: Daniel W Nebert; Ge Zhang; Elliot S Vesell
Genetic risk prediction: individualized variability in susceptibility to toxicants.
Annual review of pharmacology and toxicology 2013;53():355-75.
2013: Chad Brocker; Christopher Carpenter; Sarah Carpenter; Hans-Hubert Kirch; David Kopečný; Simeon O Kotchoni; Daniel W Nebert; Melpomene Vasiliou; Xiping Wang; Andrew J Wood; Yucheng Zhang; Vasilis Vasiliou
Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics.
Planta 2013;237(1):189-210.
2013: A N Fullenkamp; E N Haynes; Daniel W Nebert; P Succop; L Meloncon
Erratum to: Perceptions of genetic research in three rural Appalachian Ohio communities.
Journal of community genetics 2013;4(1):19.
2013: Amy N Fullenkamp; Erin N Haynes; Lisa Meloncon; Paul Succop; Daniel W Nebert
Perceptions of genetic research in three rural Appalachian Ohio communities.
Journal of community genetics 2013;4(1):9-17.
2012: Katerina Levova; Michaela Moserova; Daniel W Nebert; David H Phillips; Heinz H Schmeiser; Volker M Arlt; Eva Frei; Marie Stiborova
NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.
Toxicology and applied pharmacology 2012;265(3):360-7.
2012: Daniel W Nebert; Bin Wang; Chen Yin; Marina Gálvez-Peralta; E Ben Hay; Lei He; Elisabet Johansson; Hong Li; Manoocher Soleimani
ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition.
Metallomics : integrated biometal science 2012;4(11):1218-25.
2012: Ying Chen; Christine P Curran; Daniel W Nebert; Krishna V Patel; Michael T Williams; Charles V Vorhees
Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm(-/-) knockout mice.
Neurotoxicology and teratology 2012;34(4):450-7.
2012: Y Chen; Christine P Curran; Daniel W Nebert; K V Patel; Michael T Williams; Charles V Vorhees
Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo-/- knockout mice.
Genes, brain, and behavior 2012;11(3):269-77.
2012: Marie Stiborová; Frantisek Bárta; Eva Frei; Katerina Levová; Daniel W Nebert; David H Phillips; Heinz H Schmeiser; Zhanquan Shi; Volker M Arlt
Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.
Toxicological sciences : an official journal of the Society of Toxicology 2012;125(2):345-58.
2012: Ying Chen; Mansi Krishan; Daniel W Nebert; Howard G Shertzer
Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis.
Chemical research in toxicology 2012;25(1):94-100.
2012: Marina Gálvez-Peralta; Lei He; Lucia F Jorge-Nebert; Marian L Miller; Scott Afton; Bryan L Eppert; Bin Wang; Daniel W Nebert
ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero.
PloS one 2012;7(5):e36055.
2011: Eric L Kendig; Mansi Krishan; Daniel W Nebert; Scott N Schneider; Ying Chen; Mary Beth Genter; Elisabet Johansson; Howard G Shertzer
Lipid metabolism and body composition in Gclm(-/-) mice.
Toxicology and applied pharmacology 2011;257(3):338-48.
2011: Volker M Arlt; František Bárta; James D Evans; Eva Frei; Kateřina Levová; Daniel W Nebert; David H Phillips; Heinz H Schmeiser; Zhanquan Shi; Marie Stiborová
Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.
Chemical research in toxicology 2011;24(10):1710-9.
2011: Christine P Curran; Mary Beth Genter; Daniel W Nebert; Krishna V Patel; Tori L Schaefer; Matthew R Skelton; Michael T Williams; Charles V Vorhees
In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes.
Environmental health perspectives 2011;119(9):1286-93.
2011: Eric R Waits; Daniel W Nebert
Genetic architecture of susceptibility to PCB126-induced developmental cardiotoxicity in zebrafish.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(2):466-75.
2011: Bin Wang; Timothy P Dalton; Hongbin Dong; Lei He; Daniel W Nebert
Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn²⁺/(HCO₃⁻)₂ transporter expression.
Biochemical and biophysical research communications 2011;410(2):289-94.
2011: Brian Jackson; Daniel W Nebert; David C Thompson; Konstandinos Vasiliou; William Black; Chad Brocker; Vasilis Vasiliou
Update on the aldehyde dehydrogenase gene (ALDH) superfamily.
Human genomics 2011;5(4):283-303.
2011: Jun Ozeki; Shigeyuki Uno; Michitaka Ogura; Mihwa Choi; Tetsuyo Maeda; Kenichi Sakurai; Sadanori Matsuo; Sadao Amano; Daniel W Nebert; Makoto Makishima
Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice.
Toxicology 2011;280(1-2):10-7.
2011: Christine P Curran; Charles V Vorhees; Michael T Williams; Mary Beth Genter; Marian L Miller; Daniel W Nebert
In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(1):189-208.
2010: Ying Chen; Elisabet Johansson; Yi Yang; Marian L Miller; Dongxiao Shen; David J Orlicky; Howard G Shertzer; Vasilis Vasiliou; Daniel W Nebert; Timothy P Dalton
Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc-knockout mice, providing a model for hepatic cirrhosis.
Journal of hepatology 2010;53(6):1085-94.
2010: Zhanquan Shi; Nadine Dragin; Marian L Miller; Keith F Stringer; Elisabet Johansson; Jing Chen; Shigeyuki Uno; Frank J Gonzalez; Carlos A Rubio; Daniel W Nebert
Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.
International journal of cancer. Journal international du cancer 2010;127(10):2334-50.
2010: Chad Brocker; David Thompson; Akiko Matsumoto; Daniel W Nebert; Vasilis Vasiliou
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Human genomics 2010;5(1):30-55.
2010: Daniel W Nebert; Marina Gálvez-Peralta; Zhanquan Shi; Nadine Dragin
Inbreeding and epigenetics: beneficial as well as deleterious effects.
Nature reviews. Genetics 2010;11(9):662.
2010: Chad Brocker; Christopher Carpenter; Daniel W Nebert; Vasilis Vasiliou
Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family.
Human genomics 2010;4(6):411-20.
2010: Zhanquan Shi; Nadine Dragin; Marina Gálvez-Peralta; Lucia F Jorge-Nebert; Marian L Miller; Bin Wang; Daniel W Nebert
Organ-specific roles of CYP1A1 during detoxication of dietary benzo[a]pyrene.
Molecular pharmacology 2010;78(1):46-57.
2010: Brian C Jackson; Christopher Carpenter; Daniel W Nebert; Vasilis Vasiliou
Update of human and mouse forkhead box (FOX) gene families.
Human genomics 2010;4(5):345-52.
2010: Brian C Jackson; Daniel W Nebert; Vasilis Vasiliou
Update of human and mouse matrix metalloproteinase families.
Human genomics 2010;4(3):194-201.
2010: Yunxia Fan; Gregory P Boivin; Erik S Knudsen; Daniel W Nebert; Ying Xia; Alvaro Puga
The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis.
Cancer research 2010;70(1):212-20.
2010: Lucia F Jorge-Nebert; Zhengwen Jiang; Ranajit Chakraborty; Joanna Watson; Li Jin; Stephen T McGarvey; Ranjan Deka; Daniel W Nebert
Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations.
Human mutation 2010;31(1):27-40.
2009: William Black; Dimitrios Stagos; Satori A Marchitti; Daniel W Nebert; Keith F Tipton; Amos Bairoch; Vasilis Vasiliou
Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature.
Pharmacogenetics and genomics 2009;19(11):893-902.
2009: Chad N Brocker; Vasilis Vasiliou; Daniel W Nebert
Evolutionary divergence and functions of the ADAM and ADAMTS gene families.
Human genomics 2009;4(1):43-55.
2009: Ying Chen; Elisabet Johansson; Yunxia Fan; Howard G Shertzer; Vasilis Vasiliou; Daniel W Nebert; Timothy P Dalton
Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit.
Free radical biology & medicine 2009;47(4):410-8.
2009: Lei He; Bin Wang; Everett B Hay; Daniel W Nebert
Discovery of ZIP transporters that participate in cadmium damage to testis and kidney.
Toxicology and applied pharmacology 2009;238(3):250-7.
2009: Daniel W Nebert
Given the complexity of the human genome, can 'personalised medicine' or 'individualised drug therapy' ever be achieved?
Human genomics 2009;3(4):299-300.
2009: Sarah C Sim; Walter L Miller; Xiao-Bo Zhong; Wiebke Arlt; Tsutomu Ogata; Xinxin Ding; C Roland Wolf; Christa E Flück; Amit V Pandey; Colin Henderson; Todd D Porter; Ann K Daly; Daniel W Nebert; Magnus Ingelman-Sundberg
Nomenclature for alleles of the cytochrome P450 oxidoreductase gene.
Pharmacogenetics and genomics 2009;19(7):565-6.
2009: Shigeyuki Uno; Kaori Endo; Yuji Ishida; Chise Tateno; Makoto Makishima; Katsutoshi Yoshizato; Daniel W Nebert
CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines.
Toxicology and applied pharmacology 2009;237(1):119-26.
2009: Vasilis Vasiliou; Konstandinos Vasiliou; Daniel W Nebert
Human ATP-binding cassette (ABC) transporter family.
Human genomics 2009;3(3):281-90.
2009: Hongbin Dong; Timothy P Dalton; Marian L Miller; Ying Chen; Shigeyuki Uno; Zhanquan Shi; Howard G Shertzer; Seema Bansal; Narayan G Avadhani; Daniel W Nebert
Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle.
Molecular pharmacology 2009;75(3):555-67.
2009: Lei He; Konstandinos Vasiliou; Daniel W Nebert
Analysis and update of the human solute carrier (SLC) gene superfamily.
Human genomics 2009;3(2):195-206.
2008: Zhanquan Shi; Ying Chen; Hongbin Dong; Robyn M Amos-Kroohs; Daniel W Nebert
Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor.
Biochemical and biophysical research communications 2008;376(4):775-80.
2008: Tsviya Olender; Doron Lancet; Daniel W Nebert
Update on the olfactory receptor (OR) gene superfamily.
Human genomics 2008;3(1):87-97.
2008: Ci Ma; Scott N Schneider; Marian Miller; Daniel W Nebert; Caroline Lind; Sandy M Roda; Scott E Afton; Joseph A Caruso; Mary Beth Genter
Manganese accumulation in the mouse ear following systemic exposure.
Journal of biochemical and molecular toxicology 2008;22(5):305-10.
2008: Nadine Dragin; Zhanquan Shi; Rajat Madan; Christopher L Karp; Maureen Sartor; Chi Chen; Frank J Gonzalez; Daniel W Nebert
Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse.
Molecular pharmacology 2008;73(6):1844-56.
2008: Jonathan A Bernstein; Ge Zhang; Li Jin; Carol Abbott; Daniel W Nebert
Olfactory receptor gene polymorphisms and nonallergic vasomotor rhinitis.
The Journal of asthma : official journal of the Association for the Care of Asthma 2008;45(4):287-92.
2008: Kuppuswami Girijashanker; Lei He; Manoocher Soleimani; Jodie M Reed; Hong Li; Zhiwei Liu; Bin Wang; Timothy P Dalton; Daniel W Nebert
Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter.
Molecular pharmacology 2008;73(5):1413-23.
2008: Walter C Prozialeck; Joshua R Edwards; Daniel W Nebert; James M Woods; Aaron Barchowsky; William D Atchison
The vascular system as a target of metal toxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2008;102(2):207-18.
2008: Shigeyuki Uno; Nadine Dragin; Marian L Miller; Timothy P Dalton; Frank J Gonzalez; Daniel W Nebert
Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract.
Free radical biology & medicine 2008;44(4):570-83.
2008: Zhiwei Liu; Hong Li; Manoocher Soleimani; Kuppuswami Girijashanker; Jodie M Reed; Lei He; Timothy P Dalton; Daniel W Nebert
Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking.
Biochemical and biophysical research communications 2008;365(4):814-20.
2008: Daniel W Nebert; Ge Zhang; Elliot S Vesell
From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions.
Drug metabolism reviews 2008;40(2):187-224.
2007: Nadine Dragin; Shigeyuki Uno; Bin Wang; Timothy P Dalton; Daniel W Nebert
Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line.
Biochemical and biophysical research communications 2007;359(3):635-42.
2007: Yi Yang; Ying Chen; Elisabet Johansson; Scott N Schneider; Howard G Shertzer; Daniel W Nebert; Timothy P Dalton
Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase.
Biochemical pharmacology 2007;74(2):372-81.
2007: Howard G Shertzer; Mary Beth Genter; Glenn Talaska; Christine P Curran; Daniel W Nebert; Timothy P Dalton
7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes.
Carcinogenesis 2007;28(6):1371-8.
2007: Ying Chen; Yi Yang; Marian L Miller; Dongxiao Shen; Howard G Shertzer; Keith F Stringer; Bin Wang; Scott N Schneider; Daniel W Nebert; Timothy P Dalton
Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure.
Hepatology (Baltimore, Md.) 2007;45(5):1118-28.
2007: Bin Wang; Scott N Schneider; Nadine Dragin; Kuppuswami Girijashanker; Timothy P Dalton; Lei He; Marian L Miller; Keith F Stringer; Manoocher Soleimani; Douglas D Richardson; Daniel W Nebert
Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line.
American journal of physiology. Cell physiology 2007;292(4):C1523-35.
2007: Xiaochao Ma; Jeffrey R Idle; Michael A Malfatti; Kristopher W Krausz; Daniel W Nebert; Chong-Sheng Chen; James S Felton; David J Waxman; Frank J Gonzalez
Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Carcinogenesis 2007;28(3):732-7.
2006: Howard G Shertzer; Mary Beth Genter; Dongxiao Shen; Daniel W Nebert; Ying Chen; Timothy P Dalton
TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone.
Toxicology and applied pharmacology 2006;217(3):363-74.
2006: Daniel W Nebert; Timothy P Dalton
The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis.
Nature reviews. Cancer 2006;6(12):947-60.
2006: Daniel W Nebert; Elliot S Vesell
Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics.
Trends in pharmacological sciences 2006;27(11):580-6.
2006: Venkata Ramesh Dasari; Hindupur K Anandatheerthavarada; Marie-Anne Robin; Ettickan Boopathi; Gopa Biswas; Ji-Kang Fang; Daniel W Nebert; Narayan G Avadhani
Role of protein kinase C-mediated protein phosphorylation in mitochondrial translocation of mouse CYP1A1, which contains a non-canonical targeting signal.
The Journal of biological chemistry 2006;281(41):30834-47.
2006: Mary Beth Genter; Jennifer L Marlowe; J Kevin Kerzee; Nadine Dragin; Alvaro Puga; Timothy P Dalton; Daniel W Nebert
Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs.
Biochemical and biophysical research communications 2006;348(1):120-3.
2006: Magnus Ingelman-Sundberg; Sarah C Sim; Daniel W Nebert
Coffee, myocardial infarction, and CYP nomenclature.
JAMA : the journal of the American Medical Association 2006;296(7):764-5; author reply 765-6.
2006: Nadine Dragin; Timothy P Dalton; Marian L Miller; Howard G Shertzer; Daniel W Nebert
For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.
The Journal of biological chemistry 2006;281(27):18591-600.
2006: Lei He; Kuppuswami Girijashanker; Timothy P Dalton; Jodie Reed; Hong Li; Manoocher Soleimani; Daniel W Nebert
ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties.
Molecular pharmacology 2006;70(1):171-80.
2006: Ge Zhang; Daniel W Nebert; Ranajit Chakraborty; Li Jin
Statistical power of association using the extreme discordant phenotype design.
Pharmacogenetics and genomics 2006;16(6):401-13.
2006: Zhengwen Jiang; Nadine Dragin; Lucia F Jorge-Nebert; Martha V Martin; F Peter Guengerich; Eleni Aklillu; Magnus Ingelman-Sundberg; George J Hammons; Beverly D Lyn-Cook; Fred F Kadlubar; Shannon N Saldana; Michael Sorter; Alexander Vinks; Nassr Nassr; Oliver Von Richter; Li Jin; Daniel W Nebert
Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype.
Pharmacogenetics and genomics 2006;16(5):359-67.
2006: Mary Beth Genter; Corey D Clay; Timothy P Dalton; Hongbin Dong; Daniel W Nebert; Howard G Shertzer
Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment.
Biochemical and biophysical research communications 2006;342(4):1375-81.
2006: Shigeyuki Uno; Timothy P Dalton; Nadine Dragin; Christine P Curran; Sandrine Derkenne; Marian L Miller; Howard G Shertzer; Frank J Gonzalez; Daniel W Nebert
Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.
Molecular pharmacology 2006;69(4):1103-14.
2006: Vasilis Vasiliou; David Ross; Daniel W Nebert
Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family.
Human genomics 2006;2(5):329-35.
2006: Yifeng Li; Dandan Zhang; Wei Jin; Chunhong Shao; Pengrong Yan; Congjian Xu; Haihui Sheng; Yan Liu; Jinde Yu; Yuying Xie; Yingnan Zhao; Daru Lu; Daniel W Nebert; Donald C Harrison; Wei Huang; Li Jin
Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.
The Journal of clinical investigation 2006;116(2):506-11.
2006: Christine P Curran; Kevin A Miller; Timothy P Dalton; Charles V Vorhees; Marian L Miller; Howard G Shertzer; Daniel W Nebert
Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl.
Toxicological sciences : an official journal of the Society of Toxicology 2006;89(2):454-64.
2006: Daniel W Nebert
Comparison of gene expression in cell culture to that in the intact animal: relevance to drugs and environmental toxicants. Focus on "development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes".
American journal of physiology. Cell physiology 2006;290(1):C37-41.
2005: Ying Chen; Howard G Shertzer; Scott N Schneider; Daniel W Nebert; Timothy P Dalton
Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels.
The Journal of biological chemistry 2005;280(40):33766-74.
2005: Peter I Mackenzie; Karl Walter Bock; Brian Burchell; Chantal Guillemette; Shin-ichi Ikushiro; Takashi Iyanagi; John O Miners; Ida S Owens; Daniel W Nebert
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.
Pharmacogenetics and genomics 2005;15(10):677-85.
2005: Connie Cheung; Xiaochao Ma; Kristopher W Krausz; Shioko Kimura; Lionel Feigenbaum; Timothy P Dalton; Daniel W Nebert; Jeffrey R Idle; Frank J Gonzalez
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.
Chemical research in toxicology 2005;18(9):1471-8.
2005: Daniel W Nebert
Inter-individual susceptibility to environmental toxicants--a current assessment.
Toxicology and applied pharmacology 2005;207(2 Suppl):34-42.
2005: Dongxiao Shen; Timothy P Dalton; Daniel W Nebert; Howard G Shertzer
Glutathione redox state regulates mitochondrial reactive oxygen production.
The Journal of biological chemistry 2005;280(27):25305-12.
2005: Sandrine Derkenne; Christine P Curran; Howard G Shertzer; Timothy P Dalton; Nadine Dragin; Daniel W Nebert
Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice.
Pharmacogenetics and genomics 2005;15(7):503-11.
2005: Vasilis Vasiliou; Daniel W Nebert
Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family.
Human genomics 2005;2(2):138-43.
2005: Peter Greaves; Bruce Clothier; Reginald Davies; Fiona M Higginson; Richard E Edwards; Timothy P Dalton; Daniel W Nebert; Andrew G Smith
Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse.
Biochemical and biophysical research communications 2005;331(1):147-52.
2005: Hekun Liu; Sizhong Zhang; Jianyin Lin; Hai Li; Aimin Huang; Cuiying Xiao; Xuefei Li; Zhi-Guang Su; Chunting Wang; Daniel W Nebert; Bing Zhou; Keqin Zheng; Jiajun Shi; Guixin Li; Dejia Huang
Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese.
Metabolism: clinical and experimental 2005;54(5):568-72.
2005: Timothy P Dalton; Lei He; Bin Wang; Marian L Miller; Li Jin; Keith F Stringer; Xiaoqing Chang; C Stuart Baxter; Daniel W Nebert
Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3401-6.
2005: Zhengwen Jiang; Timothy P Dalton; Li Jin; Bin Wang; Yutaka Tsuneoka; Howard G Shertzer; Ranjan Deka; Daniel W Nebert
Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
Human mutation 2005;25(2):196-206.
2005: Daniel W Nebert
Role of host susceptibility to toxicity and cancer caused by pesticides: cytochromes P450.
Journal of biochemical and molecular toxicology 2005;19(3):184-6.
2004: Heather Elizabeth Kleiner-Hancock; Suryanarayana V Vulimiri; William B Hatten; Melissa J Reed; Daniel W Nebert; Colin R Jefcoate; John DiGiovanni
Role of cytochrome p4501 family members in the metabolic activation of polycyclic aromatic hydrocarbons in mouse epidermis.
Chemical research in toxicology 2004;17(12):1667-74.
2004: Daniel W Nebert
Conflicts of interests: declarations for all.
Environmental health perspectives 2004;112(17):A980.
2004: Timothy P Dalton; Ying Chen; Scott N Schneider; Daniel W Nebert; Howard G Shertzer
Genetically altered mice to evaluate glutathione homeostasis in health and disease.
Free radical biology & medicine 2004;37(10):1511-26.
2004: Daniel W Nebert; Vasilis Vasiliou
Analysis of the glutathione S-transferase (GST) gene family.
Human genomics 2004;1(6):460-4.
2004: Daniel W Nebert; Elliot S Vesell
Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead.
European journal of pharmacology 2004;500(1-3):267-80.
2004: Douglas G Mashek; Karin E Bornfeldt; Rosalind A Coleman; Johannes Berger; David A Bernlohr; Paul Black; Concetta C DiRusso; Steven A Farber; Wen Guo; Naohiro Hashimoto; Varsha K Khodiyar; Frans A Kuypers; Lois J Maltais; Daniel W Nebert; Alessandra Renieri; Jean E Schaffer; Andreas Stahl; Paul A Watkins; Vasilis Vasiliou; Tokuo T Yamamoto
Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.
Journal of lipid research 2004;45(10):1958-61.
2004: Daniel W Nebert; Nickolas A Sophos; Vasilis Vasiliou; David Nelson
Cyclophilin nomenclature problems, or, 'a visit from the sequence police'.
Human genomics 2004;1(5):381-8.
2004: Daniel W Nebert; Timothy P Dalton; Allan B Okey; Frank J Gonzalez
Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.
The Journal of biological chemistry 2004;279(23):23847-50.
2004: Kelan Zhang; Sizhong Zhang; Keqin Zheng; Yiping Hou; Linchuan Liao; Yong He; Li Zhang; Daniel W Nebert; Jiajun Shi; Zhi-Guang Su; Cuiying Xiao
Novel P143L polymorphism of the LCAT gene is associated with dyslipidemia in Chinese patients who have coronary atherosclerotic heart disease.
Biochemical and biophysical research communications 2004;318(1):4-10.
2004: Shigeyuki Uno; Timothy P Dalton; Sandrine Derkenne; Christine P Curran; Marian L Miller; Howard G Shertzer; Daniel W Nebert
Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation.
Molecular pharmacology 2004;65(5):1225-37.
2004: Shigeyuki Uno; Timothy P Dalton; Peter R Sinclair; Nadia Gorman; Bin Wang; Andrew G Smith; Marian L Miller; Howard G Shertzer; Daniel W Nebert
Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria.
Toxicology and applied pharmacology 2004;196(3):410-21.
2004: Cathy Wu; Daniel W Nebert
Update on genome completion and annotations: Protein Information Resource.
Human genomics 2004;1(3):229-33.
2004: Howard G Shertzer; Corey D Clay; Mary Beth Genter; Mark Chames; Scott N Schneider; Greg Oakley; Daniel W Nebert; Timothy P Dalton
Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes.
Free radical biology & medicine 2004;36(5):618-31.
2004: Howard G Shertzer; Corey D Clay; Mary Beth Genter; Scott N Schneider; Daniel W Nebert; Timothy P Dalton
Cyp1a2 protects against reactive oxygen production in mouse liver microsomes.
Free radical biology & medicine 2004;36(5):605-17.
2004: David Nelson; Daniel W Nebert
The truth about mouse, human, worms and yeast.
Human genomics 2004;1(2):146-9.
2004: David Nelson; Darryl C Zeldin; Susan M G Hoffman; Lois J Maltais; Hester M Wain; Daniel W Nebert
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.
Pharmacogenetics 2004;14(1):1-18.
2003: Shigeyuki Uno; Bin Wang; Howard G Shertzer; Daniel W Nebert; Timothy P Dalton
Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele.
Biochemical and biophysical research communications 2003;312(2):494-9.
2003: Daniel W Nebert; Hester M Wain
Update on human genome completion and annotations: gene nomenclature.
Human genomics 2003;1(1):66-71.
2003: Yutaka Tsuneoka; Timothy P Dalton; Marian L Miller; Corey D Clay; Howard G Shertzer; Glenn Talaska; Mario Medvedovic; Daniel W Nebert
4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice.
Journal of the National Cancer Institute 2003;95(16):1227-37.
2003: Matthew Z Dieter; Sarah L Freshwater; Marian L Miller; Howard G Shertzer; Timothy P Dalton; Daniel W Nebert
Pharmacological rescue of the 14CoS/14CoS mouse: hepatocyte apoptosis is likely caused by endogenous oxidative stress.
Free radical biology & medicine 2003;35(4):351-67.
2003: Marian L Miller; Anastasia Andringa; Lloyd T Turner; Timothy P Dalton; Sandrine Derkenne; Daniel W Nebert
Preservation of the negative image of tooth enamel with dental impression material enhances morphometric measurements of gingival overgrowth.
Microscopy research and technique 2003;60(5):528-36.
2003: Ralph C Nichols; Sandra Cooper; Heidi W Trask; Nadia Gorman; Timothy P Dalton; Daniel W Nebert; Jacqueline F Sinclair; Peter R Sinclair
Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.
Biochemical pharmacology 2003;65(4):545-50.
2003: Daniel W Nebert; Lucia Jorge-Nebert; Elliot S Vesell
Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 2003;3(6):361-70.
2003: Andrew G Smith; Reginald Davies; Timothy P Dalton; Marian L Miller; David J Judah; Joan Riley; Timothy W Gant; Daniel W Nebert
Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse.
EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences 2003;111(1T):45-51.
2002: Daniel W Nebert
Transcription factors and cancer: an overview.
Toxicology 2002;181-182():131-41.
2002: Yi Yang; Matthew Z Dieter; Ying Chen; Howard G Shertzer; Daniel W Nebert; Timothy P Dalton
Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response.
The Journal of biological chemistry 2002;277(51):49446-52.
2002: Daniel W Nebert
Proposal for an allele nomenclature system based on the evolutionary divergence of haplotypes.
Human mutation 2002;20(6):463-72.
2002: Zhi-Guang Su; Si Z Zhang; Yi-ping Hou; T Li; Daniel W Nebert; Li Zhang; De-jia Huang; Lin-chuan Liao; Cui-ying Xiao
Single-nucleotide polymorphisms in the lipoprotein lipase gene associated with coronary heart disease in Chinese.
European journal of pharmacology 2002;454(1):9-18.
2002: Albert P Senft; Timothy P Dalton; Daniel W Nebert; Mary Beth Genter; Alvaro Puga; Richard J Hutchinson; J Kevin Kerzee; Shigeyuki Uno; Howard G Shertzer
Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor.
Free radical biology & medicine 2002;33(9):1268-78.
2002: Daniel W Nebert; David W Russell
Clinical importance of the cytochromes P450.
Lancet 2002;360(9340):1155-62.
2002: Zhi-Guang Su; Sizhong Zhang; Daniel W Nebert; Li Zhang; Dejia Huang; Yiping Hou; Linchuan Liao; Cuiying Xiao
A novel allele in the promoter of the hepatic lipase is associated with increased concentration of HDL-C and decreased promoter activity.
Journal of lipid research 2002;43(10):1595-601.
2002: Howard G Shertzer; Timothy P Dalton; Glenn Talaska; Daniel W Nebert
Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-/-) knockout mice.
Toxicology and applied pharmacology 2002;181(1):32-7.
2002: Willy A Solis; Timothy P Dalton; Matthew Z Dieter; Sarah L Freshwater; Judy M Harrer; Lei He; Howard G Shertzer; Daniel W Nebert
Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress.
Biochemical pharmacology 2002;63(9):1739-54.
2002: Nadia Gorman; Kerry L Ross; Heidi S Walton; William J Bement; Juliana G Szakacs; Glenn S Gerhard; Timothy P Dalton; Daniel W Nebert; Richard S Eisenstein; Jacqueline F Sinclair; Peter R Sinclair
Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron.
Hepatology (Baltimore, Md.) 2002;35(4):912-21.
2002: Daniel W Nebert; Amy L Roe; Susan E Vandale; Eula Bingham; Greg Oakley
NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE review.
Genetics in medicine : official journal of the American College of Medical Genetics 2002;4(2):62-70.
2002: Willy A Solis; Nicole L Childs; Michael Weedon; Lei He; Daniel W Nebert; Timothy P Dalton
Retrovirally expressed metal response element-binding transcription factor-1 normalizes metallothionein-1 gene expression and protects cells against zinc, but not cadmium, toxicity.
Toxicology and applied pharmacology 2002;178(2):93-101.
2002: Daniel W Nebert; Gary W Stuart; Willy A Solis; Michael J Carvan
Use of reporter genes and vertebrate DNA motifs in transgenic zebrafish as sentinels for assessing aquatic pollution.
Environmental health perspectives 2002;110(1):A15.
2002: Albert P Senft; Timothy P Dalton; Daniel W Nebert; Mary Beth Genter; Richard J Hutchinson; Howard G Shertzer
Dioxin increases reactive oxygen production in mouse liver mitochondria.
Toxicology and applied pharmacology 2002;178(1):15-21.
2001: Shigeyuki Uno; Timothy P Dalton; Howard G Shertzer; Mary Beth Genter; David Warshawsky; Glenn Talaska; Daniel W Nebert
Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels.
Biochemical and biophysical research communications 2001;289(5):1049-56.
2001: Daniel W Nebert; Eula Bingham
Pharmacogenomics: out of the lab and into the community.
Trends in biotechnology 2001;19(12):519-23.
2001: Andrew G Smith; Bruce Clothier; P Carthew; Nicole L Childs; Peter R Sinclair; Daniel W Nebert; Timothy P Dalton
Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicology and applied pharmacology 2001;173(2):89-98.
2001: C Zaccaro; Sarah M Sweitzer; Sandra Pipino; Nadia Gorman; Peter R Sinclair; Jacqueline F Sinclair; Daniel W Nebert; Francesco De Matteis
Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice.
Biochemical pharmacology 2001;61(7):843-9.
2001: Matthew Z Dieter; Sarah L Freshwater; Willy A Solis; Daniel W Nebert; Timothy P Dalton
Tyrphostin [correction of Tryphostin] AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements.
Biochemical pharmacology 2001;61(2):215-25.
2000: Daniel W Nebert
Extreme discordant phenotype methodology: an intuitive approach to clinical pharmacogenetics.
European journal of pharmacology 2000;410(2-3):107-120.
2000: Timothy P Dalton; Matthew Z Dieter; Yi Yang; Howard G Shertzer; Daniel W Nebert
Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.
Biochemical and biophysical research communications 2000;279(2):324-9.
2000: Peter R Sinclair; Nadia Gorman; Heidi S Walton; William J Bement; Juliana G Szakacs; Frank J Gonzalez; Timothy P Dalton; Daniel W Nebert; Jacqueline F Sinclair
Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone.
Archives of biochemistry and biophysics 2000;384(2):383-90.
2000: Daniel W Nebert
Drug-metabolizing enzymes, polymorphisms and interindividual response to environmental toxicants.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2000;38(9):857-61.
2000: Daniel W Nebert; Matthew Z Dieter
The evolution of drug metabolism.
Pharmacology 2000;61(3):124-35.
2000: Timothy P Dalton; Willy A Solis; Daniel W Nebert; Michael J Carvan
Characterization of the MTF-1 transcription factor from zebrafish and trout cells.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2000;126(3):325-35.
2000: Daniel W Nebert
Suggestions for the nomenclature of human alleles: relevance to ecogenetics, pharmacogenetics and molecular epidemiology.
Pharmacogenetics 2000;10(4):279-90.
2000: Michael J Carvan; Willy A Solis; L Gedamu; Daniel W Nebert
Activation of transcription factors in zebrafish cell cultures by environmental pollutants.
Archives of biochemistry and biophysics 2000;376(2):320-7.
2000: Vasilis Vasiliou; T Buetler; David Eaton; Daniel W Nebert
Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines.
Biochemical pharmacology 2000;59(6):703-12.
2000: T P Dalton; M L Miller; X Wu; A Menon; E Cianciolo; Ross Allan McKinnon; P W Smith; L J Robinson; Daniel W Nebert
Refining the mouse chromosomal location of Cdm, the major gene associated with susceptibility to cadmium-induced testicular necrosis.
Pharmacogenetics 2000;10(2):141-51.
2000: Timothy P Dalton; Matthew Z Dieter; R S Matlib; Nicole L Childs; Howard G Shertzer; Mary Beth Genter; Daniel W Nebert
Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery.
Biochemical and biophysical research communications 2000;267(1):184-9.
2000: Daniel W Nebert; Timothy P Dalton; G W Stuart; Michael J Carvan
"Gene-swap knock-in" cassette in mice to study allelic differences in human genes.
Annals of the New York Academy of Sciences 2000;919():148-70.
2000: Michael J Carvan; Timothy P Dalton; G W Stuart; Daniel W Nebert
Transgenic zebrafish as sentinels for aquatic pollution.
Annals of the New York Academy of Sciences 2000;919():133-47.
2000: Peter R Sinclair; Nadia Gorman; Heidi S Walton; William J Bement; Timothy P Dalton; Jacqueline F Sinclair; Andrew G Smith; Daniel W Nebert
CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.
Toxicology and applied pharmacology 2000;162(1):60-7.
2000: Daniel W Nebert; A L Roe; Matthew Z Dieter; Willy A Solis; Yi Yang; Timothy P Dalton
Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis.
Biochemical pharmacology 2000;59(1):65-85.
1999: Howard G Shertzer; Alvaro Puga; C y Chang; P Smith; Daniel W Nebert; Kenneth D R Setchell; Timothy P Dalton
Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.
Chemico-biological interactions 1999;123(1):31-49.
1999: Vasilis Vasiliou; S F Reuter; S Williams; Alvaro Puga; Daniel W Nebert
Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): gene structure and regulation of constitutive and dioxin-inducible expression.
Pharmacogenetics 1999;9(5):569-80.
1999: Vasilis Vasiliou; Amos Bairoch; K F Tipton; Daniel W Nebert
Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping.
Pharmacogenetics 1999;9(4):421-34.
1999: A Dey; J E Jones; Daniel W Nebert
Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization.
Biochemical pharmacology 1999;58(3):525-37.
1999: Daniel W Nebert; Magnus Ingelman-Sundberg; A K Daly
Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues.
Drug metabolism reviews 1999;31(2):467-87.
1999: Charles V Vorhees; LaRonda L Morford; S L Inman; Tracy M Reed; MA Schilling; GD Cappon; Mary S Moran; Daniel W Nebert
Genetic differences in spatial learning between Dark Agouti and Sprague-Dawley strains: possible correlation with the CYP2D2 polymorphism in rats treated neonatally with methamphetamine.
Pharmacogenetics 1999;9(2):171-81.
1998: Howard G Shertzer; Daniel W Nebert; Alvaro Puga; M Ary; David M Sonntag; K Dixon; L J Robinson; E Cianciolo; Timothy P Dalton
Dioxin causes a sustained oxidative stress response in the mouse.
Biochemical and biophysical research communications 1998;253(1):44-8.
1998: A Dey; Daniel W Nebert
Markedly increased constitutive CYP1A1 mRNA levels in the fertilized ovum of the mouse.
Biochemical and biophysical research communications 1998;251(2):657-61.
1998: C T Fitzgerald; Daniel W Nebert; Alvaro Puga
Regulation of mouse Ah receptor (Ahr) gene basal expression by members of the Sp family of transcription factors.
DNA and cell biology 1998;17(9):811-22.
1998: Andrew Maier; J Micka; K Miller; T Denko; Ching-yi Chang; Daniel W Nebert
Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype.
Environmental health perspectives 1998;106(7):421-6.
1998: Mary Beth Genter; H C Liang; J Gu; X Ding; M Negishi; Ross Allan McKinnon; Daniel W Nebert
Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse.
Biochemical pharmacology 1998;55(11):1819-26.
1998: Charles V Vorhees; Tracy M Reed; MA Schilling; J E Fisher; Mary S Moran; GD Cappon; Daniel W Nebert
CYP2D1 polymorphism in methamphetamine-treated rats: genetic differences in neonatal mortality and effects on spatial learning and acoustic startle.
Neurotoxicology and teratology 1998;20(3):265-73.
1998: Peter R Sinclair; Nadia Gorman; Timothy P Dalton; Heidi S Walton; William J Bement; Jacqueline F Sinclair; Andrew G Smith; Daniel W Nebert
Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.
The Biochemical journal 1998;330 ( Pt 1)():149-53.
1998: M Yu; G A Jamieson; George Leikauf; Daniel W Nebert
Phospholipase A2 activation and increases in specific prostaglandins in the oxidatively stressed 14CoS/14CoS mouse hepatocyte line.
Biochemical pharmacology 1998;55(2):193-200.
1997: H C Liang; Ross Allan McKinnon; Daniel W Nebert
Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice.
Biochemical pharmacology 1997;54(10):1127-31.
1997: Peter I Mackenzie; Ida S Owens; Brian Burchell; Karl Walter Bock; Amos Bairoch; A Bélanger; Sylvie Fournel-Gigleux; M Green; Dean W Hum; Takashi Iyanagi; D Lancet; P Louisot; Jacques Magdalou; Jayanta Roy-Chowdhury; Joseph K Ritter; H Schachter; Thomas R Tephly; K F Tipton; Daniel W Nebert
The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.
Pharmacogenetics 1997;7(4):255-69.
1997: X X He; Daniel W Nebert; Vasilis Vasiliou; H Zhu; Howard G Shertzer
Genetic differences in alcohol drinking preference between inbred strains of mice.
Pharmacogenetics 1997;7(3):223-33.
1997: Vasilis Vasiliou; S F Reuter; Daniel W Nebert
Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice.
Biochemical and biophysical research communications 1997;233(3):631-6.
1997: J Micka; A Milatovich; A Menon; G A Grabowski; Alvaro Puga; Daniel W Nebert
Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility.
Pharmacogenetics 1997;7(2):95-101.
1997: Daniel W Nebert; Michael J Carvan
Ecogenetics: from ecology to health.
Toxicology and industrial health 1997;13(2-3):163-92.
1997: Alvaro Puga; Daniel W Nebert; Ross Allan McKinnon; A G Menon
Genetic polymorphisms in human drug-metabolizing enzymes: potential uses of reverse genetics to identify genes of toxicological relevance.
Critical reviews in toxicology 1997;27(2):199-222.
1997: Daniel W Nebert; JJ Duffy
How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress.
Biochemical pharmacology 1997;53(3):249-54.
1997: Vasilis Vasiliou; S F Reuter; TY Shiao; Alvaro Puga; Daniel W Nebert
Mouse dioxin-inducible Ahd4 gene. Structure of the 5' flanking region and transcriptional regulation.
Advances in experimental medicine and biology 1997;414():37-46.
1996: C T FitzGerald; P Fernandez-Salguero; F J Gonzalez; Daniel W Nebert; Alvaro Puga
Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins.
Archives of biochemistry and biophysics 1996;333(1):170-8.
1996: Daniel W Nebert; Ross Allan McKinnon; Alvaro Puga
Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer.
DNA and cell biology 1996;15(4):273-80.
1996: Vasilis Vasiliou; C A Kozak; R Lindahl; Daniel W Nebert
Mouse microsomal Class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping.
DNA and cell biology 1996;15(3):235-45.
1996: H C Liang; H Li; Ross Allan McKinnon; JJ Duffy; steven potter; Alvaro Puga; Daniel W Nebert
Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1671-6.
1996: David Nelson; L Koymans; T Kamataki; J J Stegeman; R Feyereisen; D J Waxman; M R Waterman; O Gotoh; M J Coon; R W Estabrook; I C Gunsalus; Daniel W Nebert
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.
Pharmacogenetics 1996;6(1):1-42.
1996: Alvaro Puga; J Micka; C Y Chang; H C Liang; Daniel W Nebert
Role of molecular biology in risk assessment.
Advances in experimental medicine and biology 1996;387():395-404.
1995: Vasilis Vasiliou; Alvaro Puga; C Y Chang; M W Tabor; Daniel W Nebert
Interaction between the Ah receptor and proteins binding to the AP-1-like electrophile response element (EpRE) during murine phase II [Ah] battery gene expression.
Biochemical pharmacology 1995;50(12):2057-68.
1995: J L Duh; H Zhu; Howard G Shertzer; Daniel W Nebert; Alvaro Puga
The Y-box motif mediates redox-dependent transcriptional activation in mouse cells.
The Journal of biological chemistry 1995;270(51):30499-507.
1995: Vasilis Vasiliou; Howard G Shertzer; Rui-Ming Liu; M Sainsbury; Daniel W Nebert
Response of [Ah] battery genes to compounds that protect against menadione toxicity.
Biochemical pharmacology 1995;50(11):1885-91.
1995: Pedro Fernandez-Salguero; Thierry Pineau; David M Hilbert; T McPhail; S S Lee; Shioko Kimura; Daniel W Nebert; Stuart Rudikoff; Jerrold M Ward; Frank J Gonzalez
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor.
Science (New York, N.Y.) 1995;268(5211):722-6.
1995: Howard G Shertzer; Vasilis Vasiliou; Rui-Ming Liu; M W Tabor; Daniel W Nebert
Enzyme induction by L-buthionine (S,R)-sulfoximine in cultured mouse hepatoma cells.
Chemical research in toxicology 1995;8(3):431-6.
1995: Vasilis Vasiliou; S F Reuter; C A Kozak; Daniel W Nebert
Mouse class 3 aldehyde dehydrogenases.
Advances in experimental medicine and biology 1995;372():151-8.
1994: Vasilis Vasiliou; M J Theurer; Alvaro Puga; S F Reuter; Daniel W Nebert
Mouse dioxin-inducible NAD(P)H: menadione oxidoreductase: NMO1 cDNA sequence and genetic differences in mRNA levels.
Pharmacogenetics 1994;4(6):341-8.
1994: Ross Allan McKinnon; Daniel W Nebert
Possible role of cytochromes P450 in lupus erythematosus and related disorders.
Lupus 1994;3(6):473-8.
1994: France Carrier; C Y Chang; J L Duh; Daniel W Nebert; Alvaro Puga
Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT).
Biochemical pharmacology 1994;48(9):1767-78.
1994: Rui-Ming Liu; Vasilis Vasiliou; H Zhu; J L Duh; M W Tabor; Alvaro Puga; Daniel W Nebert; M Sainsbury; Howard G Shertzer
Regulation of [Ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[1,2-b]indole in mouse hepatoma cell lines.
Carcinogenesis 1994;15(10):2347-52.
1994: P J Wedlund; Shioko Kimura; Frank J Gonzalez; Daniel W Nebert
1462V mutation in the human CYP1A1 gene: lack of correlation with either the Msp I 1.9 kb (M2) allele or CYP1A1 inducibility in a three-generation family of east Mediterranean descent.
Pharmacogenetics 1994;4(1):21-6.
1994: Daniel W Nebert
Drug-metabolizing enzymes in ligand-modulated transcription.
Biochemical pharmacology 1994;47(1):25-37.
1994: Daniel W Nebert
Drug metabolism and signal transduction: possible role of Ah receptor and arachidonic acid cascade in protection from ethanol toxicity.
EXS 1994;71():231-40.
1994: Daniel W Nebert; Ross Allan McKinnon
Cytochrome P450: evolution and functional diversity.
Progress in liver diseases 1994;12():63-97.
1993: Daniel W Nebert
Elevated estrogen 16 alpha-hydroxylase activity: is this a genotoxic or nongenotoxic biomarker in human breast cancer risk?
Journal of the National Cancer Institute 1993;85(23):1888-91.
1993: C Chang; D R Smith; V S Prasad; CL Sidman; Daniel W Nebert; Alvaro Puga
Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice.
Pharmacogenetics 1993;3(6):312-21.
1993: Vasilis Vasiliou; S F Reuter; C A Kozak; Daniel W Nebert
Mouse dioxin-inducible cytosolic aldehyde dehydrogenase-3: AHD4 cDNA sequence, genetic mapping, and differences in mRNA levels.
Pharmacogenetics 1993;3(6):281-90.
1993: L F Jorge; T D Arias; U Griese; Daniel W Nebert; M Eichelbaum
Evolutionary pharmacogenetics of CYP2D6 in Ngawbe Guaymi of Panama: allele-specific PCR detection of the CYP2D6B allele and RFLP analysis.
Pharmacogenetics 1993;3(5):231-8.
1993: Rui-Ming Liu; Daniel W Nebert; Howard G Shertzer
Menadione toxicity in two mouse liver established cell lines having striking genetic differences in quinone reductase activity and glutathione concentrations.
Toxicology and applied pharmacology 1993;122(1):101-7.
1993: Daniel W Nebert; Alvaro Puga; Vasilis Vasiliou
Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction.
Annals of the New York Academy of Sciences 1993;685():624-40.
1993: Vasilis Vasiliou; Alvaro Puga; Daniel W Nebert
Mouse class 3 aldehyde dehydrogenases: positive and negative regulation of gene expression.
Advances in experimental medicine and biology 1993;328():131-9.
1993: A L Pilon; C A Kozak; Daniel W Nebert; Alvaro Puga
Localization of the murine Hmg1 gene, encoding an HMG-box protein, to mouse chromosome 2.
Mammalian genome : official journal of the International Mammalian Genome Society 1993;4(10):612-4.
1992: Vasilis Vasiliou; Alvaro Puga; Daniel W Nebert
Negative regulation of the murine cytosolic aldehyde dehydrogenase-3 (Aldh-3c) gene by functional CYP1A1 and CYP1A2 proteins.
Biochemical and biophysical research communications 1992;187(1):413-9.
1992: Alvaro Puga; Daniel W Nebert; France Carrier
Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1.
DNA and cell biology 1992;11(4):269-81.
1992: France Carrier; R A Owens; Daniel W Nebert; Alvaro Puga
Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.
Molecular and cellular biology 1992;12(4):1856-63.
1992: H C Liang; Howard G Shertzer; Daniel W Nebert
"Oxidative stress" response in liver of an untreated newborn mouse having a 1.2-centimorgan deletion on chromosome 7.
Biochemical and biophysical research communications 1992;182(3):1160-5.
1992: Alvaro Puga; B Raychaudhuri; Daniel W Nebert
Transcriptional derepression of the murine Cyp1a-1 gene by mevinolin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):777-85.
1991: D D Petersen; A N Kong; L F Jorge; Daniel W Nebert; T D Arias
Debrisoquine polymorphism: novel CYP2D6 gene Bam HI restriction fragment length polymorphism in the Ngawbé Guaymí Indian of Panama.
Pharmacogenetics 1991;1(3):136-42.
1991: Daniel W Nebert; D D Petersen; Alvaro Puga
Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin.
Pharmacogenetics 1991;1(2):68-78.
1991: S J Haque; D D Petersen; Daniel W Nebert; P I Mackenzie
Isolation, sequence, and developmental expression of rat UGT2B2: the gene encoding a constitutive UDP glucuronosyltransferase that metabolizes etiocholanolone and androsterone.
DNA and cell biology 1991;10(7):515-24.
1991: A Dey; Daniel W Nebert; Keiko Ozato
The AP-1 site and the cAMP- and serum response elements of the c-fos gene are constitutively occupied in vivo.
DNA and cell biology 1991;10(7):537-44.
1991: Daniel W Nebert
Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions.
Molecular endocrinology (Baltimore, Md.) 1991;5(9):1203-14.
1991: Daniel W Nebert
Identification of genetic differences in drug metabolism: prediction of individual risk of toxicity or cancer.
Hepatology (Baltimore, Md.) 1991;14(2):398-401.
1991: Daniel W Nebert
Role of genetics and drug metabolism in human cancer risk.
Mutation research 1991;247(2):267-81.
1991: D D Petersen; C E McKinney; K Ikeya; Hana Haleem-Smith; A E Bale; O W McBride; Daniel W Nebert
Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.
American journal of human genetics 1991;48(4):720-5.
1991: Daniel W Nebert
Polymorphism of human CYP2D genes involved in drug metabolism: possible relationship to individual cancer risk.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1991;3(3):93-6.
1991: Daniel W Nebert; David Nelson; M J Coon; R W Estabrook; R Feyereisen; Y Fujii-Kuriyama; F J Gonzalez; F P Guengerich; I C Gunsalus; E F Johnson
The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.
DNA and cell biology 1991;10(1):1-14.
1990: Frank J Gonzalez; S Y Liu; C A Kozak; Daniel W Nebert
Decreased Hnf-1 gene expression in mice homozygous for a 1.2-centiMorgan deletion on chromosome 7.
DNA and cell biology 1990;9(10):771-6.
1990: B RayChaudhuri; Daniel W Nebert; Alvaro Puga
The murine Cyp1a-1 gene negatively regulates its own transcription and that of other members of the aromatic hydrocarbon-responsive [Ah] gene battery.
Molecular endocrinology (Baltimore, Md.) 1990;4(12):1773-81.
1990: R A Owens; Daniel W Nebert
Expression of the chloramphenicol acetyltransferase (CAT) reporter gene by the murine Cyp1a-2 (cytochrome P3(450)) promoter in hepatoma cell cultures.
Biochemical and biophysical research communications 1990;172(3):1109-15.
1990: Daniel W Nebert; D D Petersen; A J Fornace
Cellular responses to oxidative stress: the [Ah] gene battery as a paradigm.
Environmental health perspectives 1990;88():13-25.
1990: Alvaro Puga; B Raychaudhuri; K Salata; Y H Zhang; Daniel W Nebert
Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity.
DNA and cell biology 1990;9(6):425-36.
1990: Frank J Gonzalez; Daniel W Nebert
Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation.
Trends in genetics : TIG 1990;6(6):182-6.
1990: A Puga; Daniel W Nebert
Evolution of the P450 gene superfamily and regulation of the murine Cyp1a1 gene.
Biochemical Society transactions 1990;18(1):7-10.
1989: S W Bigelow; A C Collins; Daniel W Nebert
Selective mouse breeding for short ethanol sleep time has led to high levels of hepatic aromatic hydrocarbon (Ah) receptor.
Biochemical pharmacology 1989;38(20):3565-72.
1989: Albert J Fornace; Daniel W Nebert; M Christine Hollander; J D Luethy; M Papathanasiou; J Fargnoli; Nikki J Holbrook
Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.
Molecular and cellular biology 1989;9(10):4196-203.
1989: A Dey; Heiner Westphal; Daniel W Nebert
Cell-specific induction of mouse Cyp1a1 mRNA during development.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7446-50.
1989: John Jones; Daniel W Nebert
Transcriptional start site in the mouse Cyp1a1 (cytochrome P1450) gene.
DNA (Mary Ann Liebert, Inc.) 1989;8(7):527-34.
1989: K Ikeya; Anil K Jaiswal; R A Owens; John Jones; Daniel W Nebert; S Kimura
Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.
Molecular endocrinology (Baltimore, Md.) 1989;3(9):1399-408.
1989: D D Petersen; F J Gonzalez; V Rapic; C A Kozak; J Y Lee; John Jones; Daniel W Nebert
Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6699-703.
1989: L A Neuhold; Y Shirayoshi; Keiko Ozato; John Jones; Daniel W Nebert
Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction.
Molecular and cellular biology 1989;9(6):2378-86.
1989: Daniel W Nebert; David Nelson; M Adesnik; M J Coon; R W Estabrook; F J Gonzalez; F P Guengerich; I C Gunsalus; E F Johnson; Wilfred Byron Kemper
The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci.
DNA (Mary Ann Liebert, Inc.) 1989;8(1):1-13.
1989: Daniel W Nebert; John Jones
Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene.
The International journal of biochemistry 1989;21(3):243-52.
1988: S Percy Ivy; A Tulpule; C R Fairchild; S D Averbuch; Charles E Myers; Daniel W Nebert; W M Baird; Kenneth H Cowan
Altered regulation of P-450IA1 expression in a multidrug-resistant MCF-7 human breast cancer cell line.
The Journal of biological chemistry 1988;263(35):19119-25.
1988: Frank J Gonzalez; Radek C Skoda; Shioko Kimura; M Umeno; Uli Zanger; Daniel W Nebert; Harry V Gelboin; James P Hardwick; Urs A Meyer
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.
Nature 1988;331(6155):442-6.
1988: Frank J Gonzalez; FRancis VILBOIS; James P Hardwick; O W McBride; Daniel W Nebert; Harry V Gelboin; Urs A Meyer
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.
Genomics 1988;2(2):174-9.
1988: Daniel W Nebert
Genes encoding drug-metabolizing enzymes: possible role in human disease.
Basic life sciences 1988;43():45-64.
1987: Anil K Jaiswal; L A Neuhold; Daniel W Nebert
Human P45IA1 upstream regulatory sequences expressing the chloramphenicol acetyltransferase gene. Effect of Ha-MSV enhancer and comparison of transient with stable transformation assays.
Biochemical and biophysical research communications 1987;148(2):857-63.
1987: Daniel W Nebert; Anil K Jaiswal; U A Meyer; F J Gonzalez
Human P-450 genes: evolution, regulation and possible role in carcinogenesis.
Biochemical Society transactions 1987;15(4):586-9.
1987: Shioko Kimura; Hana Haleem-Smith; O Hankinson; Daniel W Nebert
Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast.
The EMBO journal 1987;6(7):1929-33.
1987: Anil K Jaiswal; F J Gonzalez; Daniel W Nebert
Comparison of human mouse P1450 upstream regulatory sequences in liver- and nonliver-derived cell lines.
Molecular endocrinology (Baltimore, Md.) 1987;1(4):312-20.
1987: Daniel W Nebert; M Adesnik; M J Coon; R W Estabrook; F J Gonzalez; F P Guengerich; I C Gunsalus; E F Johnson; Wilfred Byron Kemper; W Levin
The P450 gene superfamily: recommended nomenclature.
DNA (Mary Ann Liebert, Inc.) 1987;6(1):1-11.
1987: S Kimura; J C Donovan; Daniel W Nebert
Expression of the mouse P(1)450 gene during differentiation without foreign chemical stimulation.
Journal of experimental pathology 1987;3(1):61-74.
1987: Anil K Jaiswal; Daniel W Nebert; O W McBride; F J Gonzalez
Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15.
Journal of experimental pathology 1987;3(1):1-17.
1986: L A Neuhold; F J Gonzalez; Anil K Jaiswal; Daniel W Nebert
Dioxin-inducible enhancer region upstream from the mouse P(1)450 gene and interaction with a heterologous SV40 promoter.
DNA (Mary Ann Liebert, Inc.) 1986;5(5):403-11.
1986: S W Bigelow; Daniel W Nebert
The murine aromatic hydrocarbon responsiveness locus: a comparison of receptor levels and several inducible enzyme activities among recombinant inbred lines.
Journal of biochemical toxicology 1986;1(1):1-14.