FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Len Neckers

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Mouse

Phenomena

Phosphorylation

Disorders

Physiology

Signal Transduction

Co-author Network

Publications

TOP 3
Soichiro Yoshida; Didier Picard; Carole Sourbier; Manabu Tatokoro; Jane Trepel; Shinji Tsutsumi; Evangelia Vartholomaiou; Wanping Xu; Kristin Beebe; Yang Chen; Hiroshi Fukushima; Hisashi Hasumi; Kazunori Kihara; Fumitaka Koga; Min-Jung Lee; Sunmin Lee; Naoto Miyajima; Robert P Mohney; Guillaume Muhlebach; Ken Nakamura; Len Neckers
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.
Carole Sourbier; Jane Trepel; Thomas L Prince; Ranjala Ratnayake; Bradley T Scroggins; John A Beutler; Min-Jung Lee; Sunmin Lee; Young H Lee; W Marston Linehan; Peter Literati Nagy; Len Neckers
Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality.
Alessio Giubellino; Michael Landau; Min-Jung Lee; Len Neckers; Brad Scroggins; Carole Sourbier; Jane B Trepel; Weiwen Ying; Petra Bullova; Karel Pacak
Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Len Neckers (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Soichiro Yoshida; Didier Picard; Carole Sourbier; Manabu Tatokoro; Jane Trepel; Shinji Tsutsumi; Evangelia Vartholomaiou; Wanping Xu; Kristin Beebe; Yang Chen; Hiroshi Fukushima; Hisashi Hasumi; Kazunori Kihara; Fumitaka Koga; Min-Jung Lee; Sunmin Lee; Naoto Miyajima; Robert P Mohney; Guillaume Muhlebach; Ken Nakamura; Len Neckers
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(17):E1604-12.
2013: Carole Sourbier; Jane Trepel; Thomas L Prince; Ranjala Ratnayake; Bradley T Scroggins; John A Beutler; Min-Jung Lee; Sunmin Lee; Young H Lee; W Marston Linehan; Peter Literati Nagy; Len Neckers
Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality.
Cancer cell 2013;23(2):228-37.
2013: Alessio Giubellino; Michael Landau; Min-Jung Lee; Len Neckers; Brad Scroggins; Carole Sourbier; Jane B Trepel; Weiwen Ying; Petra Bullova; Karel Pacak
Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma.
PloS one 2013;8(2):e56083.
2013: Dimitra Bourboulia; Noah Gavil; HuiYing Han; Biju Isaac; Sandra M Jensen-Taubman; Len Neckers; Beiyang Wei; William G Stetler-Stevenson
TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells.
Oncotarget 2013;4(1):166-76.
2012: Aki Iwai; Sandra M Jensen-Taubman; Sunmin Lee; Naoto Miyajima; Mehdi Mollapour; Armine K Smith; William G Stetler-Stevenson; David Sun; Jane B Trepel; Shinji Tsutsumi; Xiaolin Wu; Soichiro Yoshida; Brian S Blagg; Dimitra Bourboulia; Alison C Donnelly; Len Neckers
Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells.
Cell cycle (Georgetown, Tex.) 2012;11(19):3649-55.
2012: Wanping Xu; Kristin Beebe; Anthony Couvillon; Min-Jung Lee; Robert L Matts; Yoshihiko Miyata; Mehdi Mollapour; Zach Palchick; Chrisostomos Prodromou; Bradley T Scroggins; Marco Siderius; Jane B Trepel; Suiquan Wang; Len Neckers
Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine.
Molecular cell 2012;47(3):434-43.
2012: Wanping Xu; Len Neckers
The double edge of the HSP90-CDC37 chaperone machinery: opposing determinants of kinase stability and activity.
Future oncology (London, England) 2012;8(8):939-42.
2012: Yeong Sang Kim; Vineet Kumar; Sunmin Lee; Sanjay V Malhotra; Len Neckers; Aki Iwai; Jane B Trepel
Methoxychalcone inhibitors of androgen receptor translocation and function.
Bioorganic & medicinal chemistry letters 2012;22(5):2105-9.
2012: Céline Douarre; Len Neckers; Benu Brata Das; Ilaria Dalla Rosa; Christophe E Redon; Carole Sourbier; Hongliang Zhang; Yves Pommier
Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.
PloS one 2012;7(7):e41094.
2011: Kamalika Moulick; Len Neckers; Stephen D Nimer; Fabiana Perna; Nagavarakishore Pillarsetty; Anna Rodina; Peter Smith-Jones; Tony Taldone; Ly P Vu; Danuta Zatorska; Xinyang Zhao; Hongliang Zong; Hediye Erdjument-Bromage; Erica M Gomes DaGama; Steven S Gross; Monica L Guzman; Katerina Hatzi; Thomas Ku; Steven M Larson; Ross Levine; Jason S Lewis; Ari Melnick; James H Ahn; Mary Alpaugh; Kristin Beebe; Eloisi Caldas Lopes; Leandro Cerchietti; Gabriela Chiosis
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.
Nature chemical biology 2011;7(11):818-26.
2011: Wanping Xu; Jane Trepel; Len Neckers
Ras, ROS and proteotoxic stress: a delicate balance.
Cancer cell 2011;20(3):281-2.
2011: Thomas Prince; Len Neckers
A network of its own: the unique interactome of the Hsp90 cochaperone, Sba1/p23.
Molecular cell 2011;43(2):159-60.
2011: Mehdi Mollapour; Jane Trepel; Shinji Tsutsumi; Yeong Sang Kim; Len Neckers
Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity.
Oncotarget 2011;2(5):407-17.
2011: Mehdi Mollapour; Shinji Tsutsumi; Andrew Truman; Wanping Xu; Cara K Vaughan; Kristin Beebe; Anna Konstantinova; Srinivas Vourganti; Barry Panaretou; Peter W Piper; Jane Trepel; Chrisostomos Prodromou; Laurence H Pearl; Len Neckers
Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity.
Molecular cell 2011;41(6):672-81.
2011: Mehdi Mollapour; Len Neckers
Detecting HSP90 phosphorylation.
Methods in molecular biology (Clifton, N.J.) 2011;787():67-74.
2010: Cara K Vaughan; Len Neckers; Peter W Piper
Understanding of the Hsp90 molecular chaperone reaches new heights.
Nature structural & molecular biology 2010;17(12):1400-4.
2010: Hye Sik Kong; Sunmin Lee; Kristin Beebe; Bradley Scroggins; Gopal Gupta; Min-Jung Lee; Yun-Jin Jung; Jane Trepel; Len Neckers
Emetine promotes von Hippel-Lindau-independent degradation of hypoxia-inducible factor-2α in clear cell renal carcinoma.
Molecular pharmacology 2010;78(6):1072-8.
2010: Carole Sourbier; Vladimir Valera-Romero; Alessio Giubellino; Youfeng Yang; Sunil Sudarshan; Len Neckers; W Marston Linehan
Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma.
Cell cycle (Georgetown, Tex.) 2010;9(20):4183-9.
2010: José Garcia; Sofia Barluenga; Kristin Beebe; Len Neckers; Nicolas Winssinger
Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(32):9767-71.
2010: Jane Trepel; Mehdi Mollapour; Giuseppe Giaccone; Len Neckers
Targeting the dynamic HSP90 complex in cancer.
Nature reviews. Cancer 2010;10(8):537-49.
2010: Mehdi Mollapour; Shinji Tsutsumi; Len Neckers
Hsp90 phosphorylation, Wee1 and the cell cycle.
Cell cycle (Georgetown, Tex.) 2010;9(12):2310-6.
2010: Mehdi Mollapour; Shinji Tsutsumi; Alison C Donnelly; Kristin Beebe; Mari J Tokita; Min-Jung Lee; Sunmin Lee; Giulia Morra; Dimitra Bourboulia; Bradley T Scroggins; Giorgio Colombo; Brian S Blagg; Barry Panaretou; William Stetler-Stevenson; Jane Trepel; Peter W Piper; Chrisostomos Prodromou; Laurence H Pearl; Len Neckers
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.
Molecular cell 2010;37(3):333-43.
2010: W Marston Linehan; Gennady Bratslavsky; Peter A Pinto; Laura S Schmidt; Len Neckers; Donald Bottaro; Ramaprasad Srinivasan
Molecular diagnosis and therapy of kidney cancer.
Annual review of medicine 2010;61():329-43.
2010: Youfeng Yang; Vladimir A Valera; Hesed Padilla-Nash; Carole Sourbier; Cathy D Vocke; Manish Vira; Mones Abu-Asab; Gennady Bratslavsky; Maria Tsokos; Maria J Merino; Peter A Pinto; Ramaprasad Srinivasan; Thomas Ried; Len Neckers; W Marston Linehan
UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.
Cancer genetics and cytogenetics 2010;196(1):45-55.
2010: Shivaani Kummar; Martin E Gutierrez; Erin R Gardner; Xiaohong Chen; William D Figg; Maria Zajac-Kaye; Min Chen; Seth M Steinberg; Christine A Muir; Mary Ann Yancey; Yvonne R Horneffer; Lamin Juwara; Giovanni Melillo; S Percy Ivy; Maria Merino; Len Neckers; Patricia S Steeg; BA Conley; Giuseppe Giaccone; James Doroshow; Anthony J Murgo
Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies.
European journal of cancer (Oxford, England : 1990) 2010;46(2):340-7.
2009: Sofia Barluenga; Jean-Gonzague Fontaine; Cuihua Wang; Kais Aouadi; Ruihong Chen; Kristin Beebe; Len Neckers; Nicolas Winssinger
Inhibition of HSP90 with pochoximes: SAR and structure-based insights.
Chembiochem : a European journal of chemical biology 2009;10(17):2753-9.
2009: Shinji Tsutsumi; Mehdi Mollapour; Christian Graf; Chung-Tien Lee; Bradley T Scroggins; Wanping Xu; Lenka Haslerova; Martin Hessling; Anna A Konstantinova; Jane Trepel; Barry Panaretou; Johannes Buchner; Matthias P Mayer; Chrisostomos Prodromou; Len Neckers
Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain.
Nature structural & molecular biology 2009;16(11):1141-7.
2009: Bradley T Scroggins; Len Neckers
Just say NO: nitric oxide regulation of Hsp90.
EMBO reports 2009;10(10):1093-4.
2009: Sunil Sudarshan; Carole Sourbier; Hye Sik Kong; Karen Block; Vladimir A Valera Romero; Youfeng Yang; Cynthia Galindo; Mehdi Mollapour; Bradley Scroggins; Norman Goode; Min-Jung Lee; Campbell W Gourlay; Jane Trepel; W Marston Linehan; Len Neckers
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.
Molecular and cellular biology 2009;29(15):4080-90.
2009: Suiquan Wang; Itai Pashtan; Shinji Tsutsumi; Wanping Xu; Len Neckers
Cancer cells harboring MET gene amplification activate alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors.
Cell cycle (Georgetown, Tex.) 2009;8(13):2050-6.
2009: Shinji Tsutsumi; Kristin Beebe; Len Neckers
Impact of heat-shock protein 90 on cancer metastasis.
Future oncology (London, England) 2009;5(5):679-88.
2009: W Marston Linehan; Peter A Pinto; Gennady Bratslavsky; Elizabeth Pfaffenroth; Maria Merino; Cathy D Vocke; Jorge R Toro; Donald Bottaro; Len Neckers; Laura S Schmidt; Ramaprasad Srinivasan
Hereditary kidney cancer: unique opportunity for disease-based therapy.
Cancer 2009;115(10 Suppl):2252-61.
2009: Len Neckers; Mehdi Mollapour; Shinji Tsutsumi
The complex dance of the molecular chaperone Hsp90.
Trends in biochemical sciences 2009;34(5):223-6.
2009: Len Neckers; Shinji Tsutsumi; Mehdi Mollapour
Visualizing the twists and turns of a molecular chaperone.
Nature structural & molecular biology 2009;16(3):235-6.
2009: Yeong Sang Kim; S V Alarcon; S Lee; Mao-Jung Lee; Giuseppe Giaccone; Len Neckers; Jane Trepel
Update on Hsp90 inhibitors in clinical trial.
Current topics in medicinal chemistry 2009;9(15):1479-92.
2008: Len Neckers; Utpal Tatu
Molecular chaperones in pathogen virulence: emerging new targets for therapy.
Cell host & microbe 2008;4(6):519-27.
2008: Akihiro Yano; Shinji Tsutsumi; Shiro Soga; Min-Jung Lee; Jane Trepel; Hiroyuki Osada; Len Neckers
Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15541-6.
2008: Cara K Vaughan; Mehdi Mollapour; Jennifer R Smith; Andrew Truman; Bin Hu; Valerie M Good; Barry Panaretou; Len Neckers; Paul A Clarke; Paul Workman; Peter W Piper; Chrisostomos Prodromou; Laurence H Pearl
Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.
Molecular cell 2008;31(6):886-95.
2008: Itai Pashtan; Shinji Tsutsumi; Suiquan Wang; Wanping Xu; Len Neckers
Targeting Hsp90 prevents escape of breast cancer cells from tyrosine kinase inhibition.
Cell cycle (Georgetown, Tex.) 2008;7(18):2936-41.
2008: Yukihiro Asami; Hideaki Kakeya; Yusuke Komi; Soichi Kojima; Kiyohiro Nishikawa; Kristin Beebe; Len Neckers; Hiroyuki Osada
Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation.
Cancer science 2008;99(9):1853-8.
2008: Yoonsoo Park; Akihito Kubo; Takefumi Komiya; Amy Coxon; Kristin Beebe; Len Neckers; Paul S Meltzer; Frederic J Kaye
Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras.
Cell cycle (Georgetown, Tex.) 2008;7(15):2384-91.
2008: Avital Lev; Kazuyo Takeda; Damien Zanker; Jason C Maynard; Peniel Dimberu; Elizabeth Waffarn; James Gibbs; Nir Netzer; Michael F Princiotta; Len Neckers; Didier Picard; Christopher V Nicchitta; Weisan Chen; Yoram Reiter; Jack R Bennink; jon yewdell
The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation.
Immunity 2008;28(6):787-98.
2008: Tomohiro Kajiguchi; Sunmin Lee; Min-Jung Lee; Jane Trepel; Len Neckers
KIT regulates tyrosine phosphorylation and nuclear localization of beta-catenin in mast cell leukemia.
Leukemia research 2008;32(5):761-70.
2008: Shinji Tsutsumi; B Scroggins; F Koga; Mao-Jung Lee; Jane Trepel; Sara J Felts; C Carreras; Len Neckers
A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion.
Oncogene 2008;27(17):2478-87.
2008: Sofia Barluenga; Cuihua Wang; Jean-Gonzague Fontaine; Kaïss Aouadi; Kristin Beebe; Shinji Tsutsumi; Len Neckers; Nicolas Winssinger
Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor.
Angewandte Chemie (International ed. in English) 2008;47(23):4432-5.
2008: Mariëlle I Gallegos-Ruiz; Karijn Floor; Paul Roepman; José A Rodriguez; Gerrit A Meijer; Wolter J Mooi; Ewa Jassem; Jacek Niklinski; Thomas Muley; nico van zandwijk; Egbert F Smit; Kristin Beebe; Len Neckers; Bauke Ylstra; Giuseppe Giaccone
Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target.
PloS one 2008;3(3):e0001722.
2007: Tomohiro Kajiguchi; Eun Joo Chung; Sunmin Lee; A Stine; Hitoshi Kiyoi; Tomoki Naoe; Mark Levis; Len Neckers; Jane Trepel
FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells.
Leukemia 2007;21(12):2476-84.
2007: Len Neckers; Adam Kern; Shinji Tsutsumi
Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells.
Chemistry & biology 2007;14(11):1204-6.
2007: Bradley T Scroggins; Len Neckers
Post-translational modification of heat-shock protein 90: impact on chaperone function.
Expert opinion on drug discovery 2007;2(10):1403-14.
2007: Shinji Tsutsumi; Len Neckers
Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis.
Cancer science 2007;98(10):1536-9.
2007: Wanping Xu; Shiro Soga; Kristin Beebe; M-J Lee; Yeong Sang Kim; Jane Trepel; Len Neckers
Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition.
British journal of cancer 2007;97(6):741-4.
2007: Gennady Bratslavsky; Sunil Sudarshan; Len Neckers; W Marston Linehan
Pseudohypoxic pathways in renal cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(16):4667-71.
2007: Len Neckers
Heat shock protein 90: the cancer chaperone.
Journal of biosciences 2007;32(3):517-30.
2007: Wanping Xu; Len Neckers
Targeting the molecular chaperone heat shock protein 90 provides a multifaceted effect on diverse cell signaling pathways of cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(6):1625-9.
2007: Sunil Sudarshan; W Marston Linehan; Len Neckers
HIF and fumarate hydratase in renal cancer.
British journal of cancer 2007;96(3):403-7.
2007: Sunil Sudarshan; Peter A Pinto; Len Neckers; W Marston Linehan
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
Nature clinical practice. Urology 2007;4(2):104-10.
2007: W Marston Linehan; Peter A Pinto; Ramaprasad Srinivasan; Maria Merino; Peter Choyke; Lynda Choyke; Jonathan Coleman; Jorge Toro; Gladys Glenn; Cathy D Vocke; Berton Zbar; Laura S Schmidt; Donald Bottaro; Len Neckers
Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(2 Pt 2):671s-679s.
2007: Bradley T Scroggins; Kenneth Robzyk; Dongxia Wang; Monica G Marcu; Shinji Tsutsumi; Kristin Beebe; Robert J Cotter; Sara J Felts; David O Toft; Larry M Karnitz; Neal Rosen; Len Neckers
An acetylation site in the middle domain of Hsp90 regulates chaperone function.
Molecular cell 2007;25(1):151-9.
2007: Wanping Xu; Xitong Yuan; Kristin Beebe; Zhexin Xiang; Len Neckers
Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.
Molecular and cellular biology 2007;27(1):220-8.
2006: Jean-Baptiste Lattouf; Ramaprasad Srinivasan; Peter A Pinto; W Marston Linehan; Len Neckers
Mechanisms of disease: the role of heat-shock protein 90 in genitourinary malignancy.
Nature clinical practice. Urology 2006;3(11):590-601.
2006: Edward G Mimnaugh; Wanping Xu; Michele Vos; Xitong Yuan; Len Neckers
Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade.
Molecular cancer research : MCR 2006;4(9):667-81.
2006: Fumitaka Koga; Wanping Xu; Tatiana S Karpova; James G McNally; Roland Baron; Len Neckers
Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11318-22.
2006: Gabriela Chiosis; Len Neckers
Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive.
ACS chemical biology 2006;1(5):279-84.
2006: Qingfeng Yang; You-Sun Kim; Yong Lin; Joseph Lewis; Len Neckers; Zheng-gang Liu
Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK.
EMBO reports 2006;7(6):622-7.
2006: Monica G Marcu; Yun-Jin Jung; Sunmin Lee; Eun Joo Chung; Min-Jung Lee; Jane Trepel; Len Neckers
Curcumin is an inhibitor of p300 histone acetylatransferase.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2006;2(2):169-74.
2006: Len Neckers
Using natural product inhibitors to validate Hsp90 as a molecular target in cancer.
Current topics in medicinal chemistry 2006;6(11):1163-71.
2006: Len Neckers
Chaperoning oncogenes: Hsp90 as a target of geldanamycin.
Handbook of experimental pharmacology 2006;(172):259-77.
2005: Jason Gotlib; Caroline Berubé; Joseph D Growney; Ching-Cheng Chen; Tracy I George; Christopher Williams; Tomohiro Kajiguchi; Jia Ruan; Stan L Lilleberg; Jeffrey A Durocher; Jack H Lichy; Yanfeng Wang; Pamela S Cohen; Daniel A Arber; Michael C Heinrich; Len Neckers; Stephen J Galli; D Gary Gilliland; Steven Coutré
Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation.
Blood 2005;106(8):2865-70.
2005: Jennifer S. Isaacs; Yun Jin Jung; David R Mole; Sunmin Lee; Carlos Torres-Cabala; Yuen-Li Chung; Maria Merino; Jane Trepel; Berton Zbar; Jorge Toro; Peter J Ratcliffe; W Marston Linehan; Len Neckers
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.
Cancer cell 2005;8(2):143-53.
2005: Wanping Xu; Xitong Yuan; Zhexin Xiang; Edward G Mimnaugh; Monica G Marcu; Len Neckers
Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.
Nature structural & molecular biology 2005;12(2):120-6.
2004: James L Mulshine; Len Neckers
Epithelial-directed drug delivery: influence of formulation and delivery devices.
Lung cancer (Amsterdam, Netherlands) 2004;46(3):387-92.
2004: W Marston Linehan; James R Vasselli; Ramaprasad Srinivasan; McClellan Walther; Maria Merino; Peter Choyke; Cathy D Vocke; Laura Schmidt; Jennifer S. Isaacs; Gladys Glenn; Jorge Toro; Berton Zbar; Donald Bottaro; Len Neckers
Genetic basis of cancer of the kidney: disease-specific approaches to therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 2):6282S-9S.
2004: Yong-Sok Lee; Monica G Marcu; Len Neckers
Quantum chemical calculations and mutational analysis suggest heat shock protein 90 catalyzes trans-cis isomerization of geldanamycin.
Chemistry & biology 2004;11(7):991-8.
2004: Edward G Mimnaugh; Wanping Xu; Michele Vos; Xitong Yuan; Jennifer S. Isaacs; Kheem S Bisht; David Gius; Len Neckers
Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.
Molecular cancer therapeutics 2004;3(5):551-66.
2004: Bennett Kaufman; Orit Scharf; Jeffrey Arbeit; Margaret Ashcroft; J Martin Brown; Richard K Bruick; J Donald Chapman; Sydney M Evans; Amato J Giaccia; Adrian L Harris; Eric Huang; Randall Johnson; William Kaelin; Cameron J Koch; Patrick Maxwell; James Mitchell; Len Neckers; Garth Powis; Joseph Rajendran; Gregg L Semenza; Jonathan Simons; Erik Storkebaum; Michael J Welch; Murray Whitelaw; Giovanni Melillo; S Percy Ivy
Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.
Cancer research 2004;64(9):3350-6.
2004: Jennifer S. Isaacs; Yun-Jin Jung; Len Neckers
Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway.
The Journal of biological chemistry 2004;279(16):16128-35.
2003: Wanping Xu; Xitong Yuan; Yun Jin Jung; Yongping Yang; Andrea Basso; Neal Rosen; Eun Joo Chung; Jane Trepel; Len Neckers
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.
Cancer research 2003;63(22):7777-84.
2003: Len Neckers; S Percy Ivy
Heat shock protein 90.
Current opinion in oncology 2003;15(6):419-24.
2003: Yun-Jin Jung; Jennifer S. Isaacs; Sunmin Lee; Jane Trepel; Len Neckers
IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2115-7.
2003: Len Neckers
Screening for inducers of kinase degradation.
Chemistry & biology 2003;10(7):587-9.
2003: Len Neckers
Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification.
Current medicinal chemistry 2003;10(9):733-9.
2003: YunJin Jung; Jennifer S. Isaacs; Sunmin Lee; Jane Trepel; Zheng-Gang Liu; Len Neckers
Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation.
The Biochemical journal 2003;370(Pt 3):1011-7.
2003: Jennifer S. Isaacs; Wanping Xu; Len Neckers
Heat shock protein 90 as a molecular target for cancer therapeutics.
Cancer cell 2003;3(3):213-7.
2003: Yun-Jin Jung; Jennifer S. Isaacs; Sunmin Lee; Jane Trepel; Len Neckers
Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1alpha protein.
The Journal of biological chemistry 2003;278(9):7445-52.
2003: M Nakamura; T Matsuo; J Stauffer; Len Neckers; Carol Jeanne Thiele
Retinoic acid decreases targeting of p27 for degradation via an N-myc-dependent decrease in p27 phosphorylation and an N-myc-independent decrease in Skp2.
Cell death and differentiation 2003;10(2):230-9.
2003: Gabriela Chiosis; Henri Huezo; Neal Rosen; Edward G Mimnaugh; Luke Whitesell; Len Neckers
17AAG: low target binding affinity and potent cell activity--finding an explanation.
Molecular cancer therapeutics 2003;2(2):123-9.
2002: Monica G Marcu; Melissa Doyle; Anne Bertolotti; David Ron; Linda Hendershot; Len Neckers
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
Molecular and cellular biology 2002;22(24):8506-13.
2002: Len Neckers; Katharine Neckers
Heat-shock protein 90 inhibitors as novel cancer chemotherapeutic agents.
Expert opinion on emerging drugs 2002;7(2):277-88.
2002: Wanping Xu; Monica G Marcu; Xitong Yuan; Edward G Mimnaugh; Winston Patterson; Len Neckers
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12847-52.
2002: Len Neckers
Heat shock protein 90 inhibition by 17-allylamino-17- demethoxygeldanamycin: a novel therapeutic approach for treating hormone-refractory prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(5):962-6.
2002: Xiaodan Yu; Z Sheng Guo; Monica G Marcu; Len Neckers; Dao Nguyen; G Aaron Chen; David S Schrump
Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228.
Journal of the National Cancer Institute 2002;94(7):504-13.
2002: Len Neckers
Heat shock protein 90 is a rational molecular target in breast cancer.
Breast disease 2002;15():53-60.
2002: Len Neckers
Hsp90 inhibitors as novel cancer chemotherapeutic agents.
Trends in molecular medicine 2002;8(4 Suppl):S55-61.
2001: Edward G Mimnaugh; Ganesh L Kayastha; N B McGovern; Sang-Gu Hwang; Monica G Marcu; Jane Trepel; Shi-Ying Cai; Vincent T Marchesi; Len Neckers
Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli.
Cell death and differentiation 2001;8(12):1182-96.
2001: Manasses K Yunmbam; Qingdi Q Li; Edward G Mimnaugh; Ganesh L Kayastha; Jing Jie Yu; L N Jones; Len Neckers; Eddie Reed
Effect of the proteasome inhibitor ALLnL on cisplatin sensitivity in human ovarian tumor cells.
International journal of oncology 2001;19(4):741-8.
2001: E B Agnew; Richard H Wilson; Jean L Grem; Len Neckers; DQ Bi; Chris H Takimoto
Measurement of the novel antitumor agent 17-(allylamino)-17-demethoxygeldanamycin in human plasma by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2001;755(1-2):237-43.
2001: Wanping Xu; Edward G Mimnaugh; Meredith Defelice; Christopher V Nicchitta; Monica G Marcu; Y Yarden; Len Neckers
Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90.
The Journal of biological chemistry 2001;276(5):3702-8.
2001: Qingdi Q Li; Manasses K Yunmbam; X Zhong; Jing Jie Yu; Edward G Mimnaugh; Len Neckers; Eddie Reed
Lactacystin enhances cisplatin sensitivity in resistant human ovarian cancer cell lines via inhibition of DNA repair and ERCC-1 expression.
Cellular and molecular biology (Noisy-le-Grand, France) 2001;47 Online Pub():OL61-72.
2000: Edward G Mimnaugh; Manasses K Yunmbam; Qingdi Q Li; Paolo Bonvini; Sang-Gu Hwang; Jane Trepel; Eddie Reed; Len Neckers
Prevention of cisplatin-DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors.
Biochemical pharmacology 2000;60(9):1343-54.
2000: Mercedes Garayoa; Alfredo Martínez; Sunmin Lee; Rubén Pío; Won G An; Len Neckers; Jane Trepel; Luis M Montuenga; H Ryan; R Johnson; M Gassmann; Frank Cuttitta
Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.
Molecular endocrinology (Baltimore, Md.) 2000;14(6):848-62.
2000: Joseph Lewis; Anne Devin; A Miller; Yong Lin; Y Rodriguez; Len Neckers; Zheng-gang Liu
Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation.
The Journal of biological chemistry 2000;275(14):10519-26.
2000: Paolo Bonvini; S G Hwang; M El-Gamil; P Robbins; J S Kim; Jane Trepel; Len Neckers
Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells.
Biochimica et biophysica acta 2000;1495(3):308-18.
2000: Monica G Marcu; TW Schulte; Len Neckers
Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins.
Journal of the National Cancer Institute 2000;92(3):242-8.
2000: Len Neckers
Effects of geldanamycin and other naturally occurring small molecule antagonists of heat shock protein 90 on HER2 protein expression.
Breast disease 2000;11():49-59.
1999: Len Neckers; TW Schulte; Edward G Mimnaugh
Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity.
Investigational new drugs 1999;17(4):361-73.
1999: Paolo Bonvini; S G Hwang; M El-Gamil; P Robbins; Len Neckers; Jane Trepel
Melanoma cell lines contain a proteasome-sensitive, nuclear cytoskeleton-associated pool of beta-catenin.
Annals of the New York Academy of Sciences 1999;886():208-11.
1998: Mikhail V Blagosklonny; Won G An; Larisa Y Romanova; Jane Trepel; Tito Fojo; Len Neckers
p53 inhibits hypoxia-inducible factor-stimulated transcription.
The Journal of biological chemistry 1998;273(20):11995-8.
1997: Edward G Mimnaugh; H Y Chen; James Davie; J E Celis; Len Neckers
Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response.
Biochemistry 1997;36(47):14418-29.
1997: Luke Whitesell; P Sutphin; Won G An; TW Schulte; Mikhail V Blagosklonny; Len Neckers
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Oncogene 1997;14(23):2809-16.
1997: E Kyle; Len Neckers; Chris H Takimoto; Gregory A Curt; Raymond C Bergan
Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity.
Molecular pharmacology 1997;51(2):193-200.
1997: Won G An; R C Schnur; Len Neckers; Mikhail V Blagosklonny
Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity.
Cancer chemotherapy and pharmacology 1997;40(1):60-4.
1996: Edward G Mimnaugh; C Chavany; Len Neckers
Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin.
The Journal of biological chemistry 1996;271(37):22796-801.
1996: Raymond C Bergan; E Kyle; Phuongmai Nguyen; Jane Trepel; C Ingui; Len Neckers
Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-1-integrin.
Clinical & experimental metastasis 1996;14(4):389-98.
1996: Mikhail V Blagosklonny; Jeffrey A Toretsky; S Bohen; Len Neckers
Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8379-83.
1996: Raymond C Bergan; Frances T Hakim; Gretchen N Schwartz; E Kyle; R Cepada; J M Szabo; D Fowler; Ronald E Gress; Len Neckers
Electroporation of synthetic oligodeoxynucleotides: a novel technique for ex vivo bone marrow purging.
Blood 1996;88(2):731-41.
1996: Raymond C Bergan; Len Neckers
How do antisense oligodeoxynucleotides inhibit the growth of chronic myelogenous leukemia cells?
Blood 1996;87(9):4019-20.
1996: C Chavany; Edward G Mimnaugh; P Miller; R Bitton; Phuongmai Nguyen; Jane Trepel; Luke Whitesell; R Schnur; J Moyer; Len Neckers
p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.
The Journal of biological chemistry 1996;271(9):4974-7.
1995: Mikhail V Blagosklonny; TW Schulte; Phuongmai Nguyen; Edward G Mimnaugh; Jane Trepel; Len Neckers
Taxol induction of p21WAF1 and p53 requires c-raf-1.
Cancer research 1995;55(20):4623-6.
1995: TW Schulte; Mikhail V Blagosklonny; C Ingui; Len Neckers
Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association.
The Journal of biological chemistry 1995;270(41):24585-8.
1995: C Chavany; Y Connell; Len Neckers
Contribution of sequence and phosphorothioate content to inhibition of cell growth and adhesion caused by c-myc antisense oligomers.
Molecular pharmacology 1995;48(4):738-46.
1995: Mikhail V Blagosklonny; Jeffrey A Toretsky; Len Neckers
Geldanamycin selectively destabilizes and conformationally alters mutated p53.
Oncogene 1995;11(5):933-9.
1995: Jeffrey A Toretsky; Len Neckers; Leonard H Wexler
Detection of (11;22)(q24;q12) translocation-bearing cells in peripheral blood progenitor cells of patients with Ewing's sarcoma family of tumors.
Journal of the National Cancer Institute 1995;87(5):385-6.
1995: Raymond C Bergan; E Kyle; Y Connell; Len Neckers
Inhibition of protein-tyrosine kinase activity in intact cells by the aptameric action of oligodeoxynucleotides.
Antisense research and development 1995;5(1):33-8.
1994: Raymond C Bergan; Y Connell; B Fahmy; E Kyle; Len Neckers
Aptameric inhibition of p210bcr-abl tyrosine kinase autophosphorylation by oligodeoxynucleotides of defined sequence and backbone structure.
Nucleic acids research 1994;22(11):2150-4.
1994: Angelo Rosolen; Jeffrey A Toretsky; Len Neckers
Antisense inhibition of CHP100 C-myc expression results in reduced in vitro growth kinetics and loss of in vivo tumorigenesis.
Progress in clinical and biological research 1994;385():95-101.
1993: Raymond C Bergan; Y Connell; B Fahmy; Len Neckers
Electroporation enhances c-myc antisense oligodeoxynucleotide efficacy.
Nucleic acids research 1993;21(15):3567-73.
1993: Len Neckers; Luke Whitesell
Antisense technology: biological utility and practical considerations.
The American journal of physiology 1993;265(1 Pt 1):L1-12.
1993: Angelo Rosolen; E Kyle; C Chavany; Raymond C Bergan; E T Kalman; R Crouch; Len Neckers
Effect of over-expression of bacterial ribonuclease H on the utility of antisense MYC oligodeoxynucleotides in the monocytic leukemia cell line U937.
Biochimie 1993;75(1-2):79-87.
1992: Len Neckers; Angelo Rosolen; B Fahmy; Luke Whitesell
Specific inhibition of oncogene expression in vitro and in vivo by antisense oligonucleotides.
Annals of the New York Academy of Sciences 1992;660():37-44.
1992: Len Neckers; Luke Whitesell; Angelo Rosolen; D A Geselowitz
Antisense inhibition of oncogene expression.
Critical reviews in oncogenesis 1992;3(1-2):175-231.
1989: Yoon S Cho-Chung; Timothy Clair; Pierosandro Tagliaferri; S Ally; D Katsaros; Giampaolo Tortora; Len Neckers; T L Avery; G W Crabtree; R K Robins
Site-selective cyclic AMP analogs as new biological tools in growth control, differentiation, and proto-oncogene regulation.
Cancer investigation 1989;7(2):161-77.
1988: Pierosandro Tagliaferri; D Katsaros; Timothy Clair; S Ally; Giampaolo Tortora; Len Neckers; B Rubalcava; Z Parandoosh; Y A Chang; G R Revankar
Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues.
Cancer research 1988;48(6):1642-50.
1988: Pierosandro Tagliaferri; D Katsaros; Timothy Clair; Len Neckers; R K Robins; Yoon S Cho-Chung
Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs.
The Journal of biological chemistry 1988;263(1):409-16.
1987: D Katsaros; Giampaolo Tortora; Pierosandro Tagliaferri; Timothy Clair; S Ally; Len Neckers; R K Robins; Yoon S Cho-Chung
Site-selective cyclic AMP analogs provide a new approach in the control of cancer cell growth.
FEBS letters 1987;223(1):97-103.