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Richard Needleman

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Spectroscopy, Fourier Transform Infrared

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TOP 3
Monica Bame; Richard Needleman; Patricia A Pentiak; William S A Brusilow
Effect of sex on lifespan, disease progression, and the response to methionine sulfoximine in the SOD1 G93A mouse model for ALS.
Amruta A Jambekar; Richard Needleman; Luca Nicolosi; Elena Palma; Valeria Petronilli; Andrea Rasola; Paolo Bernardi; Federica Chiara; William S A Brusilow
A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure.
Farhad Ghoddoussi; matthew galloway; Amruta Jambekar; Monica Bame; Richard Needleman; William S A Brusilow
Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS.

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All Publications

2012: Monica Bame; Richard Needleman; Patricia A Pentiak; William S A Brusilow
Effect of sex on lifespan, disease progression, and the response to methionine sulfoximine in the SOD1 G93A mouse model for ALS.
Gender medicine 2012;9(6):524-35.
2011: Amruta A Jambekar; Richard Needleman; Luca Nicolosi; Elena Palma; Valeria Petronilli; Andrea Rasola; Paolo Bernardi; Federica Chiara; William S A Brusilow
A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure.
Liver international : official journal of the International Association for the Study of the Liver 2011;31(8):1209-21.
2010: Farhad Ghoddoussi; matthew galloway; Amruta Jambekar; Monica Bame; Richard Needleman; William S A Brusilow
Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS.
Journal of the neurological sciences 2010;290(1-2):41-7.
2004: Ming Liu; William S A Brusilow; Richard Needleman
Activity of the yeast Tat2p tryptophan permease is sensitive to the anti-tumor agent 4-phenylbutyrate.
Current genetics 2004;46(5):256-68.
2003: Akio Maeda; Judith Herzfeld; Marina Belenky; Richard Needleman; Robert B Gennis; Sergei P Balashov; Thomas G Ebrey
Water-mediated hydrogen-bonded network on the cytoplasmic side of the Schiff base of the L photointermediate of bacteriorhodopsin.
Biochemistry 2003;42(48):14122-9.
2002: Andrew Grzanowski; Richard Needleman; William S A Brusilow
Immunosuppressant-like effects of phenylbutyrate on growth inhibition of Saccharomyces cerevisiae.
Current genetics 2002;41(3):142-9.
2002: Shinji Hashimoto; Masato Sasaki; Hideo Takeuchi; Richard Needleman; Janos K Lanyi
Changes in hydrogen bonding and environment of tryptophan residues on helix F of bacteriorhodopsin during the photocycle: a time-resolved ultraviolet resonance Raman study.
Biochemistry 2002;41(20):6495-503.
2002: Leonid S Brown; Richard Needleman; Janos K Lanyi
Conformational change of the E-F interhelical loop in the M photointermediate of bacteriorhodopsin.
Journal of molecular biology 2002;317(3):471-8.
2001: Shahab Rouhani; Jean-Philippe Cartailler; Marc T Facciotti; Peter J Walian; Richard Needleman; Janos K Lanyi; Robert M Glaeser; Hartmut Luecke
Crystal structure of the D85S mutant of bacteriorhodopsin: model of an O-like photocycle intermediate.
Journal of molecular biology 2001;313(3):615-28.
2001: Andrei K Dioumaev; Leonid S Brown; Richard Needleman; Janos K Lanyi
Coupling of the reisomerization of the retinal, proton uptake, and reprotonation of Asp-96 in the N photointermediate of bacteriorhodopsin.
Biochemistry 2001;40(38):11308-17.
2001: Satoru Yamaguchi; Koka Yonebayashi; H Konishi; Satoru Tuzi; Akira Naito; Janos K Lanyi; Richard Needleman; Hazime Saitô
Cytoplasmic surface structure of bacteriorhodopsin consisting of interhelical loops and C-terminal alpha helix, modified by a variety of environmental factors as studied by (13)C-NMR.
European journal of biochemistry / FEBS 2001;268(8):2218-28.
2001: Satoru Yamaguchi; Satoru Tuzi; Koka Yonebayashi; Akira Naito; Richard Needleman; Janos K Lanyi; Hazime Saitô
Surface dynamics of bacteriorhodopsin as revealed by (13)C NMR studies on [(13)C]Ala-labeled proteins: detection of millisecond or microsecond motions in interhelical loops and C-terminal alpha-helix.
Journal of biochemistry 2001;129(3):373-82.
2000: wenzhong xiao; Leonid S Brown; Richard Needleman; Janos K Lanyi; YK Shin
Light-induced rotation of a transmembrane alpha-helix in bacteriorhodopsin.
Journal of molecular biology 2000;304(5):715-21.
2000: Y Kawase; Michikazu Tanio; Atushi Kira; Satoru Yamaguchi; Satoru Tuzi; Akira Naito; M Kataoka; Janos K Lanyi; Richard Needleman; Hazime Saitô
Alteration of conformation and dynamics of bacteriorhodopsin induced by protonation of Asp 85 and deprotonation of Schiff base as studied by 13C NMR.
Biochemistry 2000;39(47):14472-80.
2000: Hartmut Luecke; Brigitte Schobert; Jean-Philippe Cartailler; HT Richter; Anja Rosengarth; Richard Needleman; Janos K Lanyi
Coupling photoisomerization of retinal to directional transport in bacteriorhodopsin.
Journal of molecular biology 2000;300(5):1237-55.
2000: Satoru Yamaguchi; Satoru Tuzi; Michikazu Tanio; Akira Naito; Janos K Lanyi; Richard Needleman; Hazime Saitô
Irreversible conformational change of bacterio-opsin induced by binding of retinal during its reconstitution to bacteriorhodopsin, as studied by (13)C NMR.
Journal of biochemistry 2000;127(5):861-9.
2000: Hideki Kandori; N Kinoshita; Y Yamazaki; A Maeda; Yoshinori Shichida; Richard Needleman; Janos K Lanyi; M Bizounok; Judith Herzfeld; Jan Raap; Johan Lugtenburg
Local and distant protein structural changes on photoisomerization of the retinal in bacteriorhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4643-8.
2000: Leonid S Brown; Richard Needleman; Janos K Lanyi
Origins of deuterium kinetic isotope effects on the proton transfers of the bacteriorhodopsin photocycle.
Biochemistry 2000;39(5):938-45.
1999: J E Millerd; A Rohrbacher; N J Brock; C K Chau; P Smith; Richard Needleman
Improved sensitivity in blue-membrane bacteriorhodopsin films.
Optics letters 1999;24(19):1355-7.
1999: Michikazu Tanio; Satoru Tuzi; Satoru Yamaguchi; R Kawaminami; Akira Naito; Richard Needleman; Janos K Lanyi; Hazime Saitô
Conformational changes of bacteriorhodopsin along the proton-conduction chain as studied with (13)C NMR of [3-(13)C]Ala-labeled protein: arg(82) may function as an information mediator.
Biophysical journal 1999;77(3):1577-84.
1999: Andrei K Dioumaev; Leonid S Brown; Richard Needleman; Janos K Lanyi
Fourier transform infrared spectra of a late intermediate of the bacteriorhodopsin photocycle suggest transient protonation of Asp-212.
Biochemistry 1999;38(31):10070-8.
1999: Hideki Kandori; N Kinoshita; Y Yamazaki; A Maeda; Yoshinori Shichida; Richard Needleman; Janos K Lanyi; M Bizounok; Judith Herzfeld; Jan Raap; Johan Lugtenburg
Structural change of threonine 89 upon photoisomerization in bacteriorhodopsin as revealed by polarized FTIR spectroscopy.
Biochemistry 1999;38(30):9676-83.
1999: Y S Chon; Hideki Kandori; Jun Sasaki; Janos K Lanyi; Richard Needleman; A Maeda
Existence of two L photointermediates of halorhodopsin from Halobacterium salinarium, differing in their protein and water FTIR bands.
Biochemistry 1999;38(29):9449-55.
1999: Michikazu Tanio; S Inoue; K Yokota; T Seki; Satoru Tuzi; Richard Needleman; Janos K Lanyi; Akira Naito; Hazime Saitô
Long-distance effects of site-directed mutations on backbone conformation in bacteriorhodopsin from solid state NMR of [1-13C]Val-labeled proteins.
Biophysical journal 1999;77(1):431-42.
1999: György Váró; Leonid S Brown; Richard Needleman; Janos K Lanyi
Binding of calcium ions to bacteriorhodopsin.
Biophysical journal 1999;76(6):3219-26.
1999: Leonid S Brown; Richard Needleman; Janos K Lanyi
Functional roles of aspartic acid residues at the cytoplasmic surface of bacteriorhodopsin.
Biochemistry 1999;38(21):6855-61.
1999: Satoru Tuzi; Satoru Yamaguchi; Michikazu Tanio; H Konishi; S Inoue; Akira Naito; Richard Needleman; Janos K Lanyi; Hazime Saitô
Location of a cation-binding site in the loop between helices F and G of bacteriorhodopsin as studied by 13C NMR.
Biophysical journal 1999;76(3):1523-31.
1999: Toshihiko Oka; Hironari Kamikubo; Fumio Tokunaga; Janos K Lanyi; Richard Needleman; Mikio Kataoka
Conformational change of helix G in the bacteriorhodopsin photocycle: investigation with heavy atom labeling and x-ray diffraction.
Biophysical journal 1999;76(2):1018-23.
1998: Michikazu Tanio; Satoru Tuzi; Satoru Yamaguchi; H Konishi; Akira Naito; Richard Needleman; Janos K Lanyi; Hazime Saitô
Evidence of local conformational fluctuations and changes in bacteriorhodopsin, dependent on lipids, detergents and trimeric structure, as studied by 13C NMR.
Biochimica et biophysica acta 1998;1375(1-2):84-92.
1998: Leonid S Brown; Andrei K Dioumaev; Richard Needleman; Janos K Lanyi
Connectivity of the retinal Schiff base to Asp85 and Asp96 during the bacteriorhodopsin photocycle: the local-access model.
Biophysical journal 1998;75(3):1455-65.
1998: Andrei K Dioumaev; Leonid S Brown; Richard Needleman; Janos K Lanyi
Partitioning of free energy gain between the photoisomerized retinal and the protein in bacteriorhodopsin.
Biochemistry 1998;37(28):9889-93.
1998: Leonid S Brown; Andrei K Dioumaev; Richard Needleman; Janos K Lanyi
Local-access model for proton transfer in bacteriorhodopsin.
Biochemistry 1998;37(11):3982-93.
1998: Andrei K Dioumaev; HT Richter; Leonid S Brown; Michikazu Tanio; Satoru Tuzi; H Saito; Y Kimura; Richard Needleman; Janos K Lanyi
Existence of a proton transfer chain in bacteriorhodopsin: participation of Glu-194 in the release of protons to the extracellular surface.
Biochemistry 1998;37(8):2496-506.
1998: Y Yamazaki; Hideki Kandori; Richard Needleman; Janos K Lanyi; A Maeda
Interaction of the protonated Schiff base with the peptide backbone of valine 49 and the intervening water molecule in the N photointermediate of bacteriorhodopsin.
Biochemistry 1998;37(6):1559-64.
1998: Satoru Yamaguchi; Satoru Tuzi; T Seki; Michikazu Tanio; Richard Needleman; Janos K Lanyi; Akira Naito; Hazime Saitô
Stability of the C-terminal alpha-helical domain of bacteriorhodopsin that protrudes from the membrane surface, as studied by high-resolution solid-state 13C NMR.
Journal of biochemistry 1998;123(1):78-86.
1997: Toshihiko Oka; Hironari Kamikubo; Fumio Tokunaga; Janos K Lanyi; Richard Needleman; Mikio Kataoka
X-ray diffraction studies of bacteriorhodopsin. Determination of the positions of mercury label at several engineered cysteine residues.
Photochemistry and photobiology 1997;66(6):768-73.
1997: TE Thorgeirsson; wenzhong xiao; Leonid S Brown; Richard Needleman; Janos K Lanyi; YK Shin
Transient channel-opening in bacteriorhodopsin: an EPR study.
Journal of molecular biology 1997;273(5):951-7.
1997: S Hashimoto; K Obata; H Takeuchi; Richard Needleman; J K Lanyi
Ultraviolet resonance Raman spectra of Trp-182 and Trp-189 in bacteriorhodopsin: novel information on the structure of Trp-182 and its steric interaction with retinal.
Biochemistry 1997;36(39):11583-90.
1997: M Hatanaka; R Kashima; Hideki Kandori; N Friedman; M Sheves; Richard Needleman; Janos K Lanyi; A Maeda
Trp86 --> Phe replacement in bacteriorhodopsin affects a water molecule near Asp85 and light adaptation.
Biochemistry 1997;36(18):5493-8.
1997: Hideki Kandori; Y Yamazaki; M Hatanaka; Richard Needleman; Leonid S Brown; HT Richter; Janos K Lanyi; A Maeda
Time-resolved fourier transform infrared study of structural changes in the last steps of the photocycles of Glu-204 and Leu-93 mutants of bacteriorhodopsin.
Biochemistry 1997;36(17):5134-41.
1997: A Maeda; Hideki Kandori; Y Yamazaki; S Nishimura; M Hatanaka; Y S Chon; Jun Sasaki; Richard Needleman; Janos K Lanyi
Intramembrane signaling mediated by hydrogen-bonding of water and carboxyl groups in bacteriorhodopsin and rhodopsin.
Journal of biochemistry 1997;121(3):399-406.
1997: Jianyong Wang; O Sirenko; Richard Needleman
Genomic footprinting of Mig1p in the MAL62 promoter. Binding is dependent upon carbon source and competitive with the Mal63p activator.
The Journal of biological chemistry 1997;272(7):4613-22.
1996: Leonid S Brown; Richard Needleman; Janos K Lanyi
Interaction of proton and chloride transfer pathways in recombinant bacteriorhodopsin with chloride transport activity: implications for the chloride translocation mechanism.
Biochemistry 1996;35(50):16048-54.
1996: HT Richter; Richard Needleman; Hideki Kandori; A Maeda; Janos K Lanyi
Relationship of retinal configuration and internal proton transfer at the end of the bacteriorhodopsin photocycle.
Biochemistry 1996;35(48):15461-6.
1996: HT Richter; Richard Needleman; Janos K Lanyi
Perturbed interaction between residues 85 and 204 in Tyr-185-->Phe and Asp-85-->Glu bacteriorhodopsins.
Biophysical journal 1996;71(6):3392-8.
1996: Y S Chon; Jun Sasaki; Hideki Kandori; Leonid S Brown; Janos K Lanyi; Richard Needleman; A Maeda
Hydration of the counterion of the Schiff base in the chloride-transporting mutant of bacteriorhodopsin: FTIR and FT-raman studies of the effects of anion binding when Asp85 is replaced with a neutral residue.
Biochemistry 1996;35(45):14244-50.
1996: Satoru Tuzi; Satoru Yamaguchi; Akira Naito; Richard Needleman; Janos K Lanyi; Hazime Saitô
Conformation and dynamics of [3-13C]Ala- labeled bacteriorhodopsin and bacterioopsin, induced by interaction with retinal and its analogs, as studied by 13C nuclear magnetic resonance.
Biochemistry 1996;35(23):7520-7.
1996: G Váró; Leonid S Brown; Richard Needleman; Janos K Lanyi
Proton transport by halorhodopsin.
Biochemistry 1996;35(21):6604-11.
1996: M Hatanaka; Jun Sasaki; Hideki Kandori; T G Ebrey; Richard Needleman; Janos K Lanyi; A Maeda
Effects of arginine-82 on the interactions of internal water molecules in bacteriorhodopsin.
Biochemistry 1996;35(20):6308-12.
1996: K C Hsu; G W Rayfield; Richard Needleman
Reversal of the surface charge asymmetry in purple membrane due to single amino acid substitutions.
Biophysical journal 1996;70(5):2358-65.
1996: Y Yamazaki; Satoru Tuzi; Hazime Saitô; Hideki Kandori; Richard Needleman; Janos K Lanyi; A Maeda
Hydrogen bonds of water and C==O groups coordinate long-range structural changes in the L photointermediate of bacteriorhodopsin.
Biochemistry 1996;35(13):4063-8.
1996: HT Richter; Leonid S Brown; Richard Needleman; Janos K Lanyi
A linkage of the pKa's of asp-85 and glu-204 forms part of the reprotonation switch of bacteriorhodopsin.
Biochemistry 1996;35(13):4054-62.
1996: Hironari Kamikubo; M Kataoka; G Váró; Toshihiko Oka; Fumio Tokunaga; Richard Needleman; Janos K Lanyi
Structure of the N intermediate of bacteriorhodopsin revealed by x-ray diffraction.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1386-90.
1996: J Wang; Richard Needleman
Removal of Mig1p binding site converts a MAL63 constitutive mutant derived by interchromosomal gene conversion to glucose insensitivity.
Genetics 1996;142(1):51-63.
1996: G Váró; Richard Needleman; Janos K Lanyi
Protein structural change at the cytoplasmic surface as the cause of cooperativity in the bacteriorhodopsin photocycle.
Biophysical journal 1996;70(1):461-7.
1995: Leonid S Brown; J Sasaki; Hideki Kandori; A Maeda; Richard Needleman; Janos K Lanyi
Glutamic acid 204 is the terminal proton release group at the extracellular surface of bacteriorhodopsin.
The Journal of biological chemistry 1995;270(45):27122-6.
1995: G Váró; Richard Needleman; Janos K Lanyi
Light-driven chloride ion transport by halorhodopsin from Natronobacterium pharaonis. 2. Chloride release and uptake, protein conformation change, and thermodynamics.
Biochemistry 1995;34(44):14500-7.
1995: G Váró; Leonid S Brown; J Sasaki; Hideki Kandori; A Maeda; Richard Needleman; Janos K Lanyi
Light-driven chloride ion transport by halorhodopsin from Natronobacterium pharaonis. 1. The photochemical cycle.
Biochemistry 1995;34(44):14490-9.
1995: Leonid S Brown; G Váró; Richard Needleman; Janos K Lanyi
Functional significance of a protein conformation change at the cytoplasmic end of helix F during the bacteriorhodopsin photocycle.
Biophysical journal 1995;69(5):2103-11.
1995: Jun Sasaki; Leonid S Brown; Y S Chon; Hideki Kandori; A Maeda; Richard Needleman; Janos K Lanyi
Conversion of bacteriorhodopsin into a chloride ion pump.
Science (New York, N.Y.) 1995;269(5220):73-5.
1995: Y Yamazaki; M Hatanaka; Hideki Kandori; Jun Sasaki; W F Karstens; Jan Raap; Johan Lugtenburg; M Bizounok; Judith Herzfeld; Richard Needleman
Water structural changes at the proton uptake site (the Thr46-Asp96 domain) in the L intermediate of bacteriorhodopsin.
Biochemistry 1995;34(21):7088-93.
1995: G Váró; László Zimányi; X Fan; L Sun; Richard Needleman; Janos K Lanyi
Photocycle of halorhodopsin from Halobacterium salinarium.
Biophysical journal 1995;68(5):2062-72.
1995: O I Sirenko; B Ni; Richard Needleman
Purification and binding properties of the Mal63p activator of Saccharomyces cerevisiae.
Current genetics 1995;27(6):509-16.
1995: Y Cao; Leonid S Brown; J Sasaki; A Maeda; Richard Needleman; Janos K Lanyi
Relationship of proton release at the extracellular surface to deprotonation of the schiff base in the bacteriorhodopsin photocycle.
Biophysical journal 1995;68(4):1518-30.
1995: Y Yamazaki; Jun Sasaki; M Hatanaka; Hideki Kandori; A Maeda; Richard Needleman; T Shinada; K Yoshihara; Leonid S Brown; Janos K Lanyi
Interaction of tryptophan-182 with the retinal 9-methyl group in the L intermediate of bacteriorhodopsin.
Biochemistry 1995;34(2):577-82.
1994: M Kataoka; Hironari Kamikubo; Fumio Tokunaga; Leonid S Brown; Y Yamazaki; A Maeda; M Sheves; Richard Needleman; Janos K Lanyi
Energy coupling in an ion pump. The reprotonation switch of bacteriorhodopsin.
Journal of molecular biology 1994;243(4):621-38.
1994: Leonid S Brown; Y Gat; Mordechai Sheves; Y Yamazaki; A Maeda; Richard Needleman; Janos K Lanyi
The retinal Schiff base-counterion complex of bacteriorhodopsin: changed geometry during the photocycle is a cause of proton transfer to aspartate 85.
Biochemistry 1994;33(40):12001-11.
1994: Leonid S Brown; Y Yamazaki; A Maeda; L Sun; Richard Needleman; Janos K Lanyi
The proton transfers in the cytoplasmic domain of bacteriorhodopsin are facilitated by a cluster of interacting residues.
Journal of molecular biology 1994;239(3):401-14.
1994: Jun Sasaki; Janos K Lanyi; Richard Needleman; T Yoshizawa; A Maeda
Complete identification of C = O stretching vibrational bands of protonated aspartic acid residues in the difference infrared spectra of M and N intermediates versus bacteriorhodopsin.
Biochemistry 1994;33(11):3178-84.
1994: Nir Friedman; S Druckmann; J Lanyi; Richard Needleman; Aaron Lewis; Michael Ottolenghi; Mordechai Sheves
A covalent link between the chromophore and the protein backbone of bacteriorhodopsin is not required for forming a photochemically active pigment analogous to the wild type.
Biochemistry 1994;33(8):1971-6.
1994: A Maeda; Jun Sasaki; Y Yamazaki; Richard Needleman; Janos K Lanyi
Interaction of aspartate-85 with a water molecule and the protonated Schiff base in the L intermediate of bacteriorhodopsin: a Fourier-transform infrared spectroscopic study.
Biochemistry 1994;33(7):1713-7.
1993: M Kataoka; K Mihara; Hironari Kamikubo; Richard Needleman; Janos K Lanyi; Fumio Tokunaga
Trimeric mutant bacteriorhodopsin, D85N, shows a monophasic CD spectrum.
FEBS letters 1993;333(1-2):111-3.
1993: Y Cao; Leonid S Brown; Richard Needleman; Janos K Lanyi
Relationship of proton uptake on the cytoplasmic surface and reisomerization of the retinal in the bacteriorhodopsin photocycle: an attempt to understand the complex kinetics of the pH changes and the N and O intermediates.
Biochemistry 1993;32(38):10239-48.
1993: Leonid S Brown; László Zimányi; Richard Needleman; Michael Ottolenghi; Janos K Lanyi
Photoreaction of the N intermediate of bacteriorhodopsin, and its relationship to the decay kinetics of the M intermediate.
Biochemistry 1993;32(30):7679-85.
1993: László Zimányi; Y Cao; Richard Needleman; Michael Ottolenghi; Janos K Lanyi
Pathway of proton uptake in the bacteriorhodopsin photocycle.
Biochemistry 1993;32(30):7669-78.
1993: Leonid S Brown; L Bonet; Richard Needleman; Janos K Lanyi
Estimated acid dissociation constants of the Schiff base, Asp-85, and Arg-82 during the bacteriorhodopsin photocycle.
Biophysical journal 1993;65(1):124-30.
1993: Y Cao; G Váró; A L Klinger; D M Czajkowsky; Mark S Braiman; Richard Needleman; Janos K Lanyi
Proton transfer from Asp-96 to the bacteriorhodopsin Schiff base is caused by a decrease of the pKa of Asp-96 which follows a protein backbone conformational change.
Biochemistry 1993;32(8):1981-90.
1993: Y N Zhang; Mostafa A El-Sayed; M L Bonet; J K Lanyi; M Chang; B Ni; Richard Needleman
Effects of genetic replacements of charged and H-bonding residues in the retinal pocket on Ca2+ binding to deionized bacteriorhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1445-9.
1992: László Zimányi; Y Cao; M Chang; B Ni; Richard Needleman; Janos K Lanyi
The two consecutive M substates in the photocycle of bacteriorhodopsin are affected specifically by the D85N and D96N residue replacements.
Photochemistry and photobiology 1992;56(6):1049-55.
1992: László Zimányi; G Váró; M Chang; B Ni; Richard Needleman; Janos K Lanyi
Pathways of proton release in the bacteriorhodopsin photocycle.
Biochemistry 1992;31(36):8535-43.
1992: A Maeda; Jun Sasaki; Yoshinori Shichida; T Yoshizawa; M Chang; B Ni; Richard Needleman; Janos K Lanyi
Structures of aspartic acid-96 in the L and N intermediates of bacteriorhodopsin: analysis by Fourier transform infrared spectroscopy.
Biochemistry 1992;31(19):4684-90.
1992: G Váró; László Zimányi; M Chang; B Ni; Richard Needleman; Janos K Lanyi
A residue substitution near the beta-ionone ring of the retinal affects the M substates of bacteriorhodopsin.
Biophysical journal 1992;61(3):820-6.
1992: S Druckmann; Nir Friedman; J K Lanyi; Richard Needleman; Michael Ottolenghi; Mordechai Sheves
The back photoreaction of the M intermediate in the photocycle of bacteriorhodopsin: mechanism and evidence for two M species.
Photochemistry and photobiology 1992;56(6):1041-7.
1991: Y Cao; G Váró; M Chang; B F Ni; Richard Needleman; Janos K Lanyi
Water is required for proton transfer from aspartate-96 to the bacteriorhodopsin Schiff base.
Biochemistry 1991;30(45):10972-9.
1991: Richard Needleman
Control of maltase synthesis in yeast.
Molecular microbiology 1991;5(9):2079-84.
1991: Richard Needleman; M Chang; B Ni; G Váró; J Fornés; S H White; Janos K Lanyi
Properties of Asp212----Asn bacteriorhodopsin suggest that Asp212 and Asp85 both participate in a counterion and proton acceptor complex near the Schiff base.
The Journal of biological chemistry 1991;266(18):11478-84.
1990: B F Ni; Richard Needleman
Identification of the upstream activating sequence of MAL and the binding sites for the MAL63 activator of Saccharomyces cerevisiae.
Molecular and cellular biology 1990;10(7):3797-800.
1990: B F Ni; M Chang; A Duschl; Janos K Lanyi; Richard Needleman
An efficient system for the synthesis of bacteriorhodopsin in Halobacterium halobium.
Gene 1990;90(1):169-72.
1989: Y S Chang; R A Dubin; Edward L Perkins; Corinne A Michels; Richard Needleman
Identification and characterization of the maltose permease in genetically defined Saccharomyces strain.
Journal of bacteriology 1989;171(11):6148-54.
1988: Y S Chang; R A Dubin; Edward L Perkins; D Forrest; Corinne A Michels; Richard Needleman
MAL63 codes for a positive regulator of maltose fermentation in Saccharomyces cerevisiae.
Current genetics 1988;14(3):201-9.
1988: Edward L Perkins; Richard Needleman
MAL64c is a global regulator of alpha-glucoside fermentation: identification of a new gene involved in melezitose fermentation.
Current genetics 1988;13(5):369-75.
1988: R A Dubin; Maureen J Charron; S R Haut; Richard Needleman; Corinne A Michels
Constitutive expression of the maltose fermentative enzymes in Saccharomyces carlsbergensis is dependent upon the mutational activation of a nonessential homolog of MAL63.
Molecular and cellular biology 1988;8(3):1027-35.
1986: R A Dubin; Edward L Perkins; Richard Needleman; Corinne A Michels
Identification of a second trans-acting gene controlling maltose fermentation in Saccharomyces carlsbergensis.
Molecular and cellular biology 1986;6(8):2757-65.
1985: R A Dubin; Richard Needleman; D Gossett; Corinne A Michels
Identification of the structural gene encoding maltase within the MAL6 locus of Saccharomyces carlsbergensis.
Journal of bacteriology 1985;164(2):605-10.
1984: Richard Needleman; D B Kaback; R A Dubin; Edward L Perkins; N G Rosenberg; K A Sutherland; D B Forrest; Corinne A Michels
MAL6 of Saccharomyces: a complex genetic locus containing three genes required for maltose fermentation.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(9):2811-5.
1984: Corinne A Michels; Richard Needleman
The dispersed, repeated family of MAL loci in Saccharomyces spp.
Journal of bacteriology 1984;157(3):949-52.
1983: Richard Needleman; Corinne A Michels
Repeated family of genes controlling maltose fermentation in Saccharomyces carlsbergensis.
Molecular and cellular biology 1983;3(5):796-802.
1982: Howard Federoff; J D Cohen; T R Eccleshall; Richard Needleman; B A Buchferer; J Giacalone; J Marmur
Isolation of a maltase structural gene from Saccharomyces carlsbergensis.
Journal of bacteriology 1982;149(3):1064-70.
1980: J D Cohen; T R Eccleshall; Richard Needleman; Howard Federoff; B A Buchferer; J Marmur
Functional expression in yeast of the Escherichia coli plasmid gene coding for chloramphenicol acetyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(2):1078-82.
1978: Richard Needleman; Howard Federoff; T R Eccleshall; B Buchferer; J Marmur
Purification and characterization of an alpha-glucosidase from Saccharomyces carlsbergensis.
Biochemistry 1978;17(22):4657-61.
1978: T R Eccleshall; Richard Needleman; E M Storm; B Buchferer; J Marmur
A temperature-sensitive yeast mitochondrial mutant with altered cytochrome c oxidase subunit.
Nature 1978;273(5657):67-70.
1975: A Tzagoloff; A Akai; Richard Needleman; G Zulch
Assembly of the mitochondrial membrane system. Cytoplasmic mutants of Saccharomyces cerevisiae with lesions in enzymes of the respiratory chain and in the mitochondrial ATPase.
The Journal of biological chemistry 1975;250(20):8236-42.
1975: A Tzagoloff; A Akai; Richard Needleman
Assembly of the mitochondrial membrane system. Characterization of nuclear mutants of Saccharomyces cerevisiae with defects in mitochondrial ATPase and respiratory enzymes.
The Journal of biological chemistry 1975;250(20):8228-35.
1975: A Tzagoloff; A Akai; Richard Needleman
Assembly of the mitochondrial membrane system: isolation of nuclear and cytoplasmic mutants of Saccharomyces cerevisiae with specific defects in mitochondrial functions.
Journal of bacteriology 1975;122(3):826-31.
1975: A Tzagoloff; A Akai; Richard Needleman
Properties of cytoplasmic mutants of Saccharomyces cerevisiae with specific lesions in cytochrome oxidase.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(6):2054-7.
1975: Richard Needleman; A Tzagoloff
Breakage of yeast: a method for processing multiple samples.
Analytical biochemistry 1975;64(2):545-9.
1974: Richard Needleman; N R Eaton
Selection of yeast mutants constitutive for maltase synthesis.
Molecular & general genetics : MGG 1974;133(2):135-40.
1974: A M ten Berge; G Zoutewelle; Richard Needleman
Regulation of maltose fermentation in Saccharomyces carlsbergensis. 3. Constitutive mutations at the MAL6-locus and suppressors changing a constitutive phenotype into a maltose negative phenotype.
Molecular & general genetics : MGG 1974;131(2):113-21.