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Benjamin Neel

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TOP 3
Gordon Chan; Shengqing Gu; Benjamin G Neel
Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis.
Matthew J Smith; Benjamin G Neel; Mitsuhiko Ikura
NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
Francis J Alenghat; Quentin J Baca; David E Golan; Clifford A Lowell; Takashi Matozaki; Benjamin G Neel; Lily I Pao; Nooreen T Rubin; Kenneth D Swanson
Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.

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2013: Gordon Chan; Shengqing Gu; Benjamin G Neel
Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis.
Blood 2013;121(18):3594-8.
2013: Matthew J Smith; Benjamin G Neel; Mitsuhiko Ikura
NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(12):4574-9.
2012: Francis J Alenghat; Quentin J Baca; David E Golan; Clifford A Lowell; Takashi Matozaki; Benjamin G Neel; Lily I Pao; Nooreen T Rubin; Kenneth D Swanson
Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.
Journal of cell science 2012;125(Pt 22):5535-45.
2012: Ziqiang Yang; Mitsuhiko Ikura; Senthil K Muthuswamy; Masataka Umitsu; Bin Xue; Benjamin G Neel
The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.
Molecular cell 2012;47(3):469-83.
2012: Benjamin G Neel; Nancy A Speck
Tyrosyl phosphorylation toggles a Runx1 switch.
Genes & development 2012;26(14):1520-6.
2012: Ben Tran; Tong Zhang; Lincoln Stein; Philippe L Bedard; Andrew M K Brown; Janet E Dancey; Thomas J Hudson; Suzanne Kamel-Reid; John D McPherson; Benjamin G Neel; Nicole Onetto; Patricia Shaw; Lillian L Siu
Cancer genomics: technology, discovery, and translation.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(6):647-60.
2012: Fawaz G Haj; Hong-Mei Han; Ali Kinkhabwala; Benjamin G Neel; Vassilis Roukos; Ola Sabet; Sabine Wimmer-Kleikamp; Claude Antony; Martin Bierbaum; Markus Grabenbauer; Philippe I H Bastiaens
Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B.
PloS one 2012;7(5):e36633.
2012: Carl Owen; Andy Welch; Abdelali Agouni; Kendra K Bence; Alicja Czopek; Olga Göransson; Louise Grant; Robert Judson; Barbara B Kahn; Emma K Lees; George D Mcilroy; Nimesh Mody; Benjamin G Neel; Mirela Delibegović
Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
PloS one 2012;7(2):e32700.
2011: Kim Loh; Benjamin G Neel; Alexander Reichenbach; Stephanie Simonds; Natalie A Sims; Florian Wiede; Sheng Zhang; Xinmei Zhang; Zhong-Yin Zhang; Zane B Andrews; Kendra K Bence; Dana Briggs; Michael Alexander cowley; Pablo J Enriori; Atsushi Fukushima; Sandra Galic; Christine Hauser; Barbara B Kahn; Tony Tiganis
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
Cell metabolism 2011;14(5):684-99.
2011: Gordon Chan; Laurene S Cheung; Wentian Yang; Michael Milyavsky; Ashley D Sanders; Shengqing Gu; Wan Xing Hong; Aurora X Liu; Xiaonan Wang; Mary Barbara; Tarun Sharma; Joehleen Gavin; Jeffery L Kutok; Norman N Iscove; Kevin M Shannon; John E Dick; Benjamin G Neel; Benjamin S Braun
Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.
Blood 2011;117(16):4253-61.
2011: Jocelyn M Stewart; Patricia A Shaw; Craig Gedye; Marcus Q Bernardini; Benjamin G Neel; Laurie Ailles
Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(16):6468-73.
2011: Talita M Marin; Kimberly Keith; Benjamin Davies; David A Conner; Prajna Guha; Demetrios Kalaitzidis; Xue Wu; Jessica Lauriol; Bo Wang; Michael Bauer; Roderick Bronson; Kleber G Franchini; Benjamin G Neel; Maria I Kontaridis
Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.
The Journal of clinical investigation 2011;121(3):1026-43.
2010: Eva Nievergall; Peter W Janes; Carolin Stegmayer; Mary E Vail; Fawaz G Haj; Shyh Wei Teng; Benjamin G Neel; Philippe I H Bastiaens; Martin Lackmann
PTP1B regulates Eph receptor function and trafficking.
The Journal of cell biology 2010;191(6):1189-203.
2010: Frank S David; Luise Cullen-McEwen; Xue Sue Wu; Stephen R Zins; Julie Lin; John F Bertram; Benjamin G Neel
Regulation of kidney development by Shp2: an unbiased stereological analysis.
Anatomical record (Hoboken, N.J. : 2007) 2010;293(12):2147-53.
2010: Rodney A Stewart; Takaomi Sanda; Hans R Widlund; Shizhen Zhu; Kenneth D Swanson; Aeron D Hurley; Mohamed Bentires-Alj; David E Fisher; Maria I Kontaridis; A Thomas Look; Benjamin G Neel
Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis.
Developmental cell 2010;18(5):750-62.
2010: Mohammad T Mazhab-Jafari; Christopher B Marshall; Matthew Smith; Geneviève M C Gasmi-Seabrook; Vuk Stambolic; Robert Rottapel; Benjamin G Neel; Mitsuhiko Ikura
Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.
The Journal of biological chemistry 2010;285(8):5132-6.
2009: Gordon Chan; Demetrios Kalaitzidis; Tatiana Usenko; Jeffery L Kutok; Wentian Yang; M Golam Mohi; Benjamin G Neel
Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.
Blood 2009;113(18):4414-24.
2009: Mirela Delibegovic; Derek Zimmer; Caitlin Kauffman; Kimberly Rak; Eun-Gyoung Hong; You-Ree Cho; Jason K Kim; Barbara B Kahn; Benjamin G Neel; Kendra K Bence
Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.
Diabetes 2009;58(3):590-9.
2008: Kenneth D Swanson; Yong Tang; Derek F Ceccarelli; Florence Poy; Jan P Sliwa; Benjamin G Neel; Michael J Eck
The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch.
Molecular cell 2008;32(4):564-75.
2008: Janice M Zabolotny; Young-Bum Kim; Laura A Welsh; Erin E Kershaw; Benjamin G Neel; Barbara B Kahn
Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.
The Journal of biological chemistry 2008;283(21):14230-41.
2008: Maria I Kontaridis; Wentian Yang; Kendra K Bence; Darragh Cullen; Bo Wang; Natalya Bodyak; Qingen Ke; Aleksander Hinek; Peter M Kang; Ronglih Liao; Benjamin G Neel
Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways.
Circulation 2008;117(11):1423-35.
2008: Kenneth D Swanson; Jordan M Winter; Marcelo Reis; Mohamed Bentires-Alj; Heidi Greulich; Rupinder Grewal; Ralph Hruban; Charles J Yeo; Yosuf Yassin; Oleg Iartchouk; Kate Montgomery; Susan P Whitman; Michael A Caligiuri; Mignon L Loh; D Gary Gilliland; A Thomas Look; Raju Kucherlapati; Scott E Kern; Matthew Meyerson; Benjamin G Neel
SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients.
Genes, chromosomes & cancer 2008;47(3):253-9.
2007: Mirela Delibegovic; Kendra K Bence; Nimesh Mody; Eun-Gyoung Hong; Hwi Jin Ko; Jason K Kim; Barbara B Kahn; Benjamin G Neel
Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.
Molecular and cellular biology 2007;27(21):7727-34.
2007: Bingzhong Xue; Young-Bum Kim; Anna Lee; Elena Toschi; Susan Bonner-Weir; C Ronald Kahn; Benjamin G Neel; Barbara B Kahn
Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
The Journal of biological chemistry 2007;282(33):23829-40.
2007: Lily I Pao; Kong-Peng Lam; Joel M Henderson; Jeffery L Kutok; Marat Alimzhanov; Lars Nitschke; Matthew L Thomas; Benjamin G Neel; Klaus Rajewsky
B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.
Immunity 2007;27(1):35-48.
2007: Christian P Kratz; Charlotte M Niemeyer; C Thomas; S Bauhuber; Verena Matejas; Eva Bergsträsser; Christian Flotho; N J Flores; Oskar A Haas; Henrik Hasle; Marry M van den Heuvel-Eibrink; Raju Kucherlapati; Peter Lang; Amy E Roberts; Jan Starý; Brigitte Strahm; Kenneth D Swanson; Monika M Trebo; Marco Zecca; Benjamin G Neel; Franco Locatelli; Mignon L Loh; Martin Zenker
Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemia.
Leukemia 2007;21(5):1108-9.
2007: Mohamed Bentires-Alj; Benjamin G Neel
Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.
Cancer research 2007;67(6):2420-4.
2007: M Golam Mohi; Benjamin G Neel
The role of Shp2 (PTPN11) in cancer.
Current opinion in genetics & development 2007;17(1):23-30.
2007: Ana Kasirer-Friede; Barry Moran; Jennifer Nagrampa-Orje; Ken Swanson; Zaverio M Ruggeri; Burkhart Schraven; Benjamin G Neel; Gary A Koretzky; Sanford J Shattil
ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.
Blood 2007;109(3):1018-25.
2007: Lily I Pao; Karen Badour; Katherine A Siminovitch; Benjamin G Neel
Nonreceptor protein-tyrosine phosphatases in immune cell signaling.
Annual review of immunology 2007;25():473-523.
2007: Shrikrishna Dadke; Sophie Cotteret; Shu-Chin Yip; Zahara M Jaffer; Fawaz G Haj; Alexey Ivanov; Frank Rauscher; Ke Shuai; Tony Ng; Benjamin G Neel; Jonathan Chernoff
Regulation of protein tyrosine phosphatase 1B by sumoylation.
Nature cell biology 2007;9(1):80-5.
2007: Amy E Roberts; Toshiyuki Araki; Kenneth D Swanson; Kate T Montgomery; Taryn A Schiripo; Victoria A Joshi; Li Li; Yosuf Yassin; Alex M Tamburino; Benjamin G Neel; Raju Kucherlapati
Germline gain-of-function mutations in SOS1 cause Noonan syndrome.
Nature genetics 2007;39(1):70-4.
2006: Min Yu; Jincai Luo; Wentian Yang; Yongping Wang; Masao Mizuki; Yuzuru Kanakura; Peter Besmer; Benjamin G Neel; Haihua Gu
The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway.
The Journal of biological chemistry 2006;281(39):28615-26.
2006: Kendra K Bence; Mirela Delibegovic; Bingzhong Xue; Cem Z Gorgun; Gökhan S Hotamisligil; Benjamin G Neel; Barbara B Kahn
Neuronal PTP1B regulates body weight, adiposity and leptin action.
Nature medicine 2006;12(8):917-24.
2006: Maria I Kontaridis; Kenneth D Swanson; Frank S David; David Barford; Benjamin G Neel
PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects.
The Journal of biological chemistry 2006;281(10):6785-92.
2006: Mohamed Bentires-Alj; Maria I Kontaridis; Benjamin G Neel
Stops along the RAS pathway in human genetic disease.
Nature medicine 2006;12(3):283-5.
2006: Wentian Yang; Lori D Klaman; Binbin Chen; Toshiyuki Araki; Hisashi Harada; Sheila M Thomas; Elizabeth L George; Benjamin G Neel
An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival.
Developmental cell 2006;10(3):317-27.
2006: Min Yu; Cliff A Lowell; Benjamin G Neel; Haihua Gu
Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2421-9.
2006: Mohamed Bentires-Alj; Susana G Gil; Richard Chan; Zhigang C Wang; Yongping Wang; Naoko Imanaka; Lyndsay N Harris; Andrea Richardson; Benjamin G Neel; Haihua Gu
A role for the scaffolding adapter GAB2 in breast cancer.
Nature medicine 2006;12(1):114-21.
2005: Heike Keilhack; Frank S David; Malcolm McGregor; Lewis C Cantley; Benjamin G Neel
Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes.
The Journal of biological chemistry 2005;280(35):30984-93.
2005: Mauro Togni; Kenneth D Swanson; S Reimann; Stefanie Kliche; A C Pearce; Luca Simeoni; Dirk Reinhold; Jürgen Wienands; Benjamin G Neel; Burkhart Schraven; Annegret Gerber
Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.
Molecular and cellular biology 2005;25(18):8052-63.
2005: Shu-Yue Ren; Elisabeth Bolton; M Golam Mohi; Andrea Morrione; Benjamin G Neel; Tomasz Skorski
Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.
Molecular and cellular biology 2005;25(18):8001-8.
2005: Elena G Arias-Salgado; Fawaz G Haj; Christophe Dubois; Barry Moran; Ana Kasirer-Friede; Barbara C Furie; Bruce Furie; Benjamin G Neel; Sanford J Shattil
PTP-1B is an essential positive regulator of platelet integrin signaling.
The Journal of cell biology 2005;170(5):837-45.
2005: Ursula G B Haider; Thomas U Roos; Maria I Kontaridis; Benjamin G Neel; Dan Sorescu; Kathy K Griendling; Angelika M Vollmar; Verena M Dirsch
Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2.
Molecular pharmacology 2005;68(1):41-8.
2005: Shairaz Baksh; Stella Tommasi; Sarah Fenton; Victor C Yu; L Miguel Martins; Gerd P Pfeifer; Farida Latif; Julian Downward; Benjamin G Neel
The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death.
Molecular cell 2005;18(6):637-50.
2005: Fawaz G Haj; Janice M Zabolotny; Young-Bum Kim; Barbara B Kahn; Benjamin G Neel
Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.
The Journal of biological chemistry 2005;280(15):15038-46.
2005: M Golam Mohi; Ifor Williams; Charles R Dearolf; Gordon Chan; Jeffery L Kutok; Sarah Cohen; Kelly Morgan; Christina L Boulton; Hirokazu Shigematsu; Heike Keilhack; Koichi Akashi; D Gary Gilliland; Benjamin G Neel
Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.
Cancer cell 2005;7(2):179-91.
2005: Sandra Galic; Christine Hauser; Barbara B Kahn; Fawaz G Haj; Benjamin G Neel; Nicholas K Tonks; Tony Tiganis
Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.
Molecular and cellular biology 2005;25(2):819-29.
2004: Mohamed Bentires-Alj; J Guillermo Paez; Frank S David; Heike Keilhack; Balazs Halmos; Katsuhiko Naoki; John M Maris; Andrea Richardson; Alberto Bardelli; David J Sugarbaker; William G Richards; Jinyan Du; Luc Girard; John D Minna; Mignon L Loh; David E Fisher; Victor E Velculescu; Bert Vogelstein; Matthew Meyerson; William R Sellers; Benjamin G Neel
Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.
Cancer research 2004;64(24):8816-20.
2004: Toshiyuki Araki; M Golam Mohi; Fraz A Ismat; Roderick T Bronson; Ifor Williams; Jeffery L Kutok; Wentian Yang; Lily I Pao; D Gary Gilliland; Jonathan A Epstein; Benjamin G Neel
Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.
Nature medicine 2004;10(8):849-57.
2004: Janice M Zabolotny; Fawaz G Haj; Young-Bum Kim; Hyo-Jeong Kim; Gerald I Shulman; Jason K Kim; Benjamin G Neel; Barbara B Kahn
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
The Journal of biological chemistry 2004;279(23):24844-51.
2004: Jie Chen; Paul A McLean; Benjamin G Neel; Gbolahan Okunade; Gary E Shull; Henry H Wortis
CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity.
Nature immunology 2004;5(6):651-7.
2004: M Golam Mohi; Christina L Boulton; Ting-Lei Gu; David W Sternberg; Donna Neuberg; James D Griffin; D Gary Gilliland; Benjamin G Neel
Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3130-5.
2004: Camilla Persson; Catrine Sävenhed; Annie Bourdeau; Michel L Tremblay; Boyka Markova; Frank-D Böhmer; Fawaz G Haj; Benjamin G Neel; Ari Elson; Carl-Henrik Heldin; Lars Rönnstrand; Arne Ostman; Carina Hellberg
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
Molecular and cellular biology 2004;24(5):2190-201.
2004: Si Qing Zhang; Wentian Yang; Maria I Kontaridis; Trever Bivona; Gengyun Wen; Toshiyuki Araki; Jincai Luo; Julie A Thompson; Burkhart L Schraven; Mark R Philips; Benjamin G Neel
Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.
Molecular cell 2004;13(3):341-55.
2004: Jake A Kushner; Fawaz G Haj; Lori D Klaman; Matthew A Dow; Barbara B Kahn; Benjamin G Neel; Morris F White
Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.
Diabetes 2004;53(1):61-6.
2003: Toshiyuki Araki; Hiroyuki Nawa; Benjamin G Neel
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.
The Journal of biological chemistry 2003;278(43):41677-84.
2003: Haihua Gu; Benjamin G Neel
The "Gab" in signal transduction.
Trends in cell biology 2003;13(3):122-30.
2003: Sarah H Bates; Walter H Stearns; Trevor A Dundon; Markus Schubert; Annette W K Tso; Yongping Wang; Alexander S Banks; Hugh J Lavery; Asma K Haq; Eleftheria Maratos-Flier; Benjamin G Neel; Michael W Schwartz; Martin G Myers Jr
STAT3 signalling is required for leptin regulation of energy balance but not reproduction.
Nature 2003;421(6925):856-9.
2003: Fawaz G Haj; Boyka Markova; Lori D Klaman; Frank D Bohmer; Benjamin G Neel
Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B.
The Journal of biological chemistry 2003;278(2):739-44.
2002: Susan J Miller; David Y Lou; David C Seldin; William Stratton Lane; Benjamin G Neel
Direct identification of PTEN phosphorylation sites.
FEBS letters 2002;528(1-3):145-53.
2002: Martin Sattler; M Golam Mohi; Yuri B Pride; Laura R Quinnan; Nicole A Malouf; klaus podar; Franck Gesbert; Hiromi Iwasaki; Shaoguang Li; Richard A Van Etten; Haihua Gu; James D Griffin; Benjamin G Neel
Critical role for Gab2 in transformation by BCR/ABL.
Cancer cell 2002;1(5):479-92.
2002: Si Qing Zhang; William G Tsiaras; Toshiyuki Araki; Gengyun Wen; Liliana Minichiello; Ruediger Klein; Benjamin G Neel
Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.
Molecular and cellular biology 2002;22(12):4062-72.
2002: Lei Jin; Paul A McLean; Benjamin G Neel; Henry H Wortis
Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling.
The Journal of experimental medicine 2002;195(9):1199-205.
2002: Janice M Zabolotny; Kendra K Bence-Hanulec; Alain Stricker-Krongrad; Fawaz G Haj; Yongping Wang; Yasuhiko Minokoshi; Young-Bum Kim; Joel K Elmquist; Louis A Tartaglia; Barbara B Kahn; Benjamin G Neel
PTP1B regulates leptin signal transduction in vivo.
Developmental cell 2002;2(4):489-95.
2002: Fawaz G Haj; Peter J Verveer; Anthony Squire; Benjamin G Neel; Philippe I H Bastiaens
Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum.
Science (New York, N.Y.) 2002;295(5560):1708-11.
2001: B Bruecher-Encke; James D Griffin; Benjamin G Neel; U Lorenz
Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation.
Leukemia 2001;15(9):1424-32.
2001: Haihua Gu; K Saito; Lori D Klaman; J Shen; Tony Fleming; Y Wang; JC Pratt; G Lin; B Lim; Jean-Pierre Kinet; Benjamin G Neel
Essential role for Gab2 in the allergic response.
Nature 2001;412(6843):186-90.
2001: Janice M Zabolotny; Young-Bum Kim; Odile D Peroni; Jason K Kim; Michael Aleksander Pani; Olivier Boss; Lori D Klaman; S Kamatkar; Gerald I Shulman; Barbara B Kahn; Benjamin G Neel
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5187-92.
2001: Dwayne Barber; Bryan K Beattie; Jacqueline M Mason; Melody H-H Nguyen; M Yoakim; Benjamin G Neel; Alan D D'Andrea; David A Frank
A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation.
Blood 2001;97(8):2230-7.
2001: Christian Bjørbaek; R M Buchholz; SM Davis; Sarah H Bates; Dominique D Pierroz; H Gu; Benjamin G Neel; Martin G Myers Jr; Jeffrey S Flier
Divergent roles of SHP-2 in ERK activation by leptin receptors.
The Journal of biological chemistry 2001;276(7):4747-55.
2000: JC Pratt; V E Igras; H Maeda; Shairaz Baksh; Erwin W Gelfand; Steven J Burakoff; Benjamin G Neel; Haihua Gu
Cutting edge: gab2 mediates an inhibitory phosphatidylinositol 3'-kinase pathway in T cell antigen receptor signaling.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4158-63.
2000: Haihua Gu; H Maeda; James J Moon; JD Lord; M Yoakim; Brad H Nelson; Benjamin G Neel
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway.
Molecular and cellular biology 2000;20(19):7109-20.
2000: Lori D Klaman; Olivier Boss; Odile D Peroni; Jason K Kim; J L Martino; Janice M Zabolotny; N Moghal; M Lubkin; Young-Bum Kim; A H Sharpe; Alain Stricker-Krongrad; Gerald I Shulman; Benjamin G Neel; Barbara B Kahn
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.
Molecular and cellular biology 2000;20(15):5479-89.
2000: C L Venable; EU Frevert; Young-Bum Kim; B M Fischer; S Kamatkar; Benjamin G Neel; Barbara B Kahn
Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation.
The Journal of biological chemistry 2000;275(24):18318-26.
2000: Binbin Chen; R T Bronson; Lori D Klaman; T G Hampton; J F Wang; P J Green; Terry Magnuson; Pamela S Douglas; J P Morgan; Benjamin G Neel
Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis.
Nature genetics 2000;24(3):296-9.
2000: A M O'Reilly; S Pluskey; Steven E Shoelson; Benjamin G Neel
Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps.
Molecular and cellular biology 2000;20(1):299-311.
1999: John Francis Timms; Kenneth D Swanson; Anne Marie-Cardine; M Raab; C E Rudd; B Schraven; Benjamin G Neel
SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages.
Current biology : CB 1999;9(16):927-30.
1999: Barbara A Miller; Dwayne Barber; LL Bell; Bryan K Beattie; Min-Ying Zhang; Benjamin G Neel; M Yoakim; Lawrence Rothblum; Joseph Y Cheung
Identification of the erythropoietin receptor domain required for calcium channel activation.
The Journal of biological chemistry 1999;274(29):20465-72.
1999: Lewis C Cantley; Benjamin G Neel
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4240-5.
1999: E S Oh; Haihua Gu; T M Saxton; John Francis Timms; S Hausdorff; EU Frevert; Barbara B Kahn; T Pawson; Benjamin G Neel; Sheila M Thomas
Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.
Molecular and cellular biology 1999;19(4):3205-15.
1998: Haihua Gu; JC Pratt; Steven J Burakoff; Benjamin G Neel
Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation.
Molecular cell 1998;2(6):729-40.
1998: N Moghal; Benjamin G Neel
Integration of growth factor, extracellular matrix, and retinoid signals during bronchial epithelial cell differentiation.
Molecular and cellular biology 1998;18(11):6666-78.
1998: Y Wu; MJ Nadler; L A Brennan; G D Gish; John Francis Timms; Noemi Fusaki; J Jongstra-Bilen; N Tada; T Pawson; Joan E Wither; Benjamin G Neel; Nobumichi Hozumi
The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1.
Current biology : CB 1998;8(18):1009-17.
1998: John Francis Timms; K Carlberg; Haihua Gu; H Chen; S Kamatkar; MJ Nadler; Larry R Rohrschneider; Benjamin G Neel
Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages.
Molecular and cellular biology 1998;18(7):3838-50.
1998: David Van Vactor; A M O'Reilly; Benjamin G Neel
Genetic analysis of protein tyrosine phosphatases.
Current opinion in genetics & development 1998;8(1):112-26.
1998: A M O'Reilly; Benjamin G Neel
Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction.
Molecular and cellular biology 1998;18(1):161-77.
1997: MJ Nadler; Paul A McLean; Benjamin G Neel; Henry H Wortis
B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4233-43.
1997: MJ Nadler; Binbin Chen; J S Anderson; Henry H Wortis; Benjamin G Neel
Protein-tyrosine phosphatase SHP-1 is dispensable for FcgammaRIIB-mediated inhibition of B cell antigen receptor activation.
The Journal of biological chemistry 1997;272(32):20038-43.
1997: Haihua Gu; James D Griffin; Benjamin G Neel
Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells.
The Journal of biological chemistry 1997;272(26):16421-30.
1997: V I Shifrin; R J Davis; Benjamin G Neel
Phosphorylation of protein-tyrosine phosphatase PTP-1B on identical sites suggests activation of a common signaling pathway during mitosis and stress response in mammalian cells.
The Journal of biological chemistry 1997;272(5):2957-62.
1996: U Lorenz; Kodi S Ravichandran; Steven J Burakoff; Benjamin G Neel
Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9624-9.
1996: U Lorenz; A D Bergemann; H N Steinberg; John G Flanagan; X Li; S J Galli; Benjamin G Neel
Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1.
The Journal of experimental medicine 1996;184(3):1111-26.
1996: H E Chen; S Chang; T Trub; Benjamin G Neel
Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1.
Molecular and cellular biology 1996;16(7):3685-97.
1996: A M Bennett; S F Hausdorff; A M O'Reilly; R M Freeman; Benjamin G Neel
Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression.
Molecular and cellular biology 1996;16(3):1189-202.
1995: Keiji Itoh; T L Tang; Benjamin G Neel; Sergei Y Sokol
Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase.
Development (Cambridge, England) 1995;121(12):3979-88.
1995: M David; H E Chen; S Goelz; Andrew C Larner; Benjamin G Neel
Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1.
Molecular and cellular biology 1995;15(12):7050-8.
1995: N Moghal; Benjamin G Neel
Evidence for impaired retinoic acid receptor-thyroid hormone receptor AF-2 cofactor activity in human lung cancer.
Molecular and cellular biology 1995;15(7):3945-59.
1995: S F Hausdorff; A M Bennett; Benjamin G Neel; Morris J Birnbaum
Different signaling roles of SHPTP2 in insulin-induced GLUT1 expression and GLUT4 translocation.
The Journal of biological chemistry 1995;270(22):12965-8.
1995: Ursula Klingmüller; U Lorenz; L C Cantley; Benjamin G Neel; Harvey Lodish
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.
Cell 1995;80(5):729-38.
1995: T L Tang; R M Freeman; A M O'Reilly; Benjamin G Neel; Sergei Y Sokol
The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development.
Cell 1995;80(3):473-83.
1994: D Pei; U Lorenz; Ursula Klingmüller; Benjamin G Neel; Christopher T Walsh
Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains.
Biochemistry 1994;33(51):15483-93.
1994: A M Bennett; T L Tang; S Sugimoto; Christopher T Walsh; Benjamin G Neel
Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7335-9.
1994: S Sugimoto; T J Wandless; Steven E Shoelson; Benjamin G Neel; Christopher T Walsh
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.
The Journal of biological chemistry 1994;269(18):13614-22.
1994: R D Case; E Piccione; G Wolf; A M Benett; R J Lechleider; Benjamin G Neel; Steven E Shoelson
SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides.
The Journal of biological chemistry 1994;269(14):10467-74.
1994: J V Frangioni; N Moghal; Alan K Stuart-Tilley; Benjamin G Neel; Seth L Alper
The DNA binding domain of retinoic acid receptor beta is required for ligand-dependent suppression of proliferation. Application of general purpose mammalian coexpression vectors.
Journal of cell science 1994;107 ( Pt 4)():827-38.
1994: U Lorenz; Kodi S Ravichandran; D Pei; Christopher T Walsh; Steven J Burakoff; Benjamin G Neel
Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells.
Molecular and cellular biology 1994;14(3):1824-34.
1993: V I Shifrin; Benjamin G Neel
Growth factor-inducible alternative splicing of nontransmembrane phosphotyrosine phosphatase PTP-1B pre-mRNA.
The Journal of biological chemistry 1993;268(34):25376-84.
1993: Benjamin G Neel
Structure and function of SH2-domain containing tyrosine phosphatases.
Seminars in cell biology 1993;4(6):419-32.
1993: J V Frangioni; A Oda; M Smith; E W Salzman; Benjamin G Neel
Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets.
The EMBO journal 1993;12(12):4843-56.
1993: S Sugimoto; R J Lechleider; Steven E Shoelson; Benjamin G Neel; Christopher T Walsh
Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2.
The Journal of biological chemistry 1993;268(30):22771-6.
1993: R J Lechleider; S Sugimoto; A M Bennett; A S Kashishian; J A Cooper; Steven E Shoelson; Christopher T Walsh; Benjamin G Neel
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.
The Journal of biological chemistry 1993;268(29):21478-81.
1993: R J Lechleider; R M Freeman; Benjamin G Neel
Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2.
The Journal of biological chemistry 1993;268(18):13434-8.
1993: J V Frangioni; Benjamin G Neel
Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal.
Journal of cell science 1993;105 ( Pt 2)():481-8.
1993: J V Frangioni; Benjamin G Neel
Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins.
Analytical biochemistry 1993;210(1):179-87.
1993: D Pei; Benjamin G Neel; Christopher T Walsh
Overexpression, purification, and characterization of SHPTP1, a Src homology 2-containing protein-tyrosine-phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(3):1092-6.
1992: R M Freeman; Jorge Plutzky; Benjamin G Neel
Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11239-43.
1992: Jorge Plutzky; Benjamin G Neel; R D Rosenberg; RL Eddy; M G Byers; S Jani-Sait; TB Shows
Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6).
Genomics 1992;13(3):869-72.
1992: J V Frangioni; P H Beahm; V Shifrin; C A Jost; Benjamin G Neel
The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence.
Cell 1992;68(3):545-60.
1992: Jorge Plutzky; Benjamin G Neel; R D Rosenberg
Isolation of a src homology 2-containing tyrosine phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(3):1123-7.
1991: J F Gebert; N Moghal; J V Frangioni; D J Sugarbaker; Benjamin G Neel
High frequency of retinoic acid receptor beta abnormalities in human lung cancer.
Oncogene 1991;6(10):1859-68.
1990: Jonathan Chernoff; A R Schievella; C A Jost; Raymond L. Erikson; Benjamin G Neel
Cloning of a cDNA for a major human protein-tyrosine-phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2735-9.