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Sriram Neelamegham

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Physiology

Anatomy

Neutrophils

Phenomena

Chemicals & Drugs

Concepts & Ideas

Procedures

Flow Cytometry

Activities & Behaviors

Computer Simulation

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Co-Publications
Name
13
Simon, Scott
9
Matta, Khushi
8
Shankaran, Harish
8
Smith, Wayne
5
Taylor, AD
4
Zhang, Yi
4
Chandrasekaran, EV
4
Alexandridis, Paschalis
3
Beauharnois, Mark
3
Burns, Alan
3
Hellums, David
3
Xue, Jun
2
Xia, Jie
2
Vanderslice, Peter
2
Locke, Robert

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Publications

TOP 3
Themistou Efrosyni; Singh Indrajeet; Shang Chengwei; Balu-Iyer Sathy V; Alexandridis Paschalis; Neelamegham Sriram
Application of fluorescence spectroscopy to quantify shear-induced protein conformation change.
Jayakumar Deepak; Marathe Dhananjay D; Neelamegham Sriram
Detection of site-specific glycosylation in proteins using flow cytometry.
Singh Indrajeet; Themistou Efrosyni; Porcar Lionel; Neelamegham Sriram
Fluid shear induces conformation change in human blood protein von Willebrand factor in solution.

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All Publications

2009: Themistou Efrosyni; Singh Indrajeet; Shang Chengwei; Balu-Iyer Sathy V; Alexandridis Paschalis; Neelamegham Sriram
Application of fluorescence spectroscopy to quantify shear-induced protein conformation change.
Biophysical journal 2009;97(9):2567-76.
2009: Jayakumar Deepak; Marathe Dhananjay D; Neelamegham Sriram
Detection of site-specific glycosylation in proteins using flow cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(10):866-73.
2009: Singh Indrajeet; Themistou Efrosyni; Porcar Lionel; Neelamegham Sriram
Fluid shear induces conformation change in human blood protein von Willebrand factor in solution.
Biophysical journal 2009;96(6):2313-20.
2008: Liu Gang; Marathe Dhananjay D; Matta Khushi L; Neelamegham Sriram
Systems-level modeling of cellular glycosylation reaction networks: O-linked glycan formation on natural selectin ligands.
Bioinformatics (Oxford, England) 2008;24(23):2740-7.
2008: Marathe Dhananjay D; Chandrasekaran E V; Lau Joseph T Y; Matta Khushi L; Neelamegham Sriram
Systems-level studies of glycosyltransferase gene expression and enzyme activity that are associated with the selectin binding function of human leukocytes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(12):4154-67.
2008: Xiao Zhihua; Visentin Gian P; Dayananda Kannayakanahalli M; Neelamegham Sriram
Immune complexes formed following the binding of anti-platelet factor 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion.
Blood 2008;112(4):1091-100.
2008: Diamond Scott L; Lawrence Michael B; Neelamegham Sriram
Harry L. Goldsmith, Ph.d.
Annals of biomedical engineering 2008;36(4):523-6.
2008: Zhang Yi; Hayenga Heather N; Sarantos Melissa R; Simon Scott I; Neelamegham Sriram
Differential regulation of neutrophil CD18 integrin function by di- and tri-valent cations: manganese vs. gadolinium.
Annals of biomedical engineering 2008;36(4):647-60.
2008: Liu Gang; Neelamegham Sriram
In silico Biochemical Reaction Network Analysis (IBRENA): a package for simulation and analysis of reaction networks.
Bioinformatics (Oxford, England) 2008;24(8):1109-11.
2008: Chandrasekaran E V; Xue Jun; Xia Jie; Locke Robert D; Matta Khushi L; Neelamegham Sriram
Reversible sialylation: synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid from cytidine 5'-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products.
Biochemistry 2008;47(1):320-30.
2006: Singh Indrajeet; Shankaran Harish; Beauharnois Mark E; Xiao Zhihua; Alexandridis Paschalis; Neelamegham Sriram
Solution structure of human von Willebrand factor studied using small angle neutron scattering.
The Journal of biological chemistry 2006;281(50):38266-75.
2006: Chandrasekaran E V; Xue Jun; Neelamegham Sriram; Matta Khushi L
The pattern of glycosyl- and sulfotransferase activities in cancer cell lines: a predictor of individual cancer-associated distinct carbohydrate structures for the structural identification of signature glycans.
Carbohydrate research 2006;341(8):983-94.
2006: Xiao Zhihua; Goldsmith Harry L; McIntosh Fiona A; Shankaran Harish; Neelamegham Sriram
Biomechanics of P-selectin PSGL-1 bonds: shear threshold and integrin-independent cell adhesion.
Biophysical journal 2006;90(6):2221-34.
2006: Beauharnois Mark E; Neelamegham Sriram; Matta Khushi L
Quantitative measurement of selectin-ligand interactions: assays to identify a sweet pill in a library of carbohydrates.
Methods in molecular biology (Clifton, N.J.) 2006;347():343-58.
2005: Chandrasekaran E V; Xue Jun; Xia Jie; Chawda Ram; Piskorz Conrad; Locke Robert D; Neelamegham Sriram; Matta Khushi L
Analysis of the specificity of sialyltransferases toward mucin core 2, globo, and related structures. identification of the sialylation sequence and the effects of sulfate, fucose, methyl, and fluoro substituents of the carbohydrate chain in the biosynthesis of selectin and siglec ligands, and novel sialylation by cloned alpha2,3(O)sialyltransferase.
Biochemistry 2005;44(47):15619-35.
2005: Beauharnois Mark E; Lindquist Kevin C; Marathe Dhananjay; Vanderslice Peter; Xia Jie; Matta Khushi L; Neelamegham Sriram
Affinity and kinetics of sialyl Lewis-X and core-2 based oligosaccharides binding to L- and P-selectin.
Biochemistry 2005;44(27):9507-19.
2005: Liu Gang; Swihart Mark T; Neelamegham Sriram
Sensitivity, principal component and flux analysis applied to signal transduction: the case of epidermal growth factor mediated signaling.
Bioinformatics (Oxford, England) 2005;21(7):1194-202.
2004: McDonough Daniel B; McIntosh Fiona A; Spanos Constantina; Neelamegham Sriram; Goldsmith Harry L; Simon Scott I
Cooperativity between selectins and beta2-integrins define neutrophil capture and stable adhesion in shear flow.
Annals of biomedical engineering 2004;32(9):1179-92.
2004: Chandrasekaran E V; Lakhaman Sukhwinder S; Chawda Ram; Piskorz Conrad F; Neelamegham Sriram; Matta Khushi L
Identification of physiologically relevant substrates for cloned Gal: 3-O-sulfotransferases (Gal3STs): distinct high affinity of Gal3ST-2 and LS180 sulfotransferase for the globo H backbone, Gal3ST-3 for N-glycan multiterminal Galbeta1, 4GlcNAcbeta units and 6-sulfoGalbeta1, 4GlcNAcbeta, and Gal3ST-4 for the mucin core-2 trisaccharide.
The Journal of biological chemistry 2004;279(11):10032-41.
2004: Neelamegham Sriram
Transport features, reaction kinetics and receptor biomechanics controlling selectin and integrin mediated cell adhesion.
Cell communication & adhesion 2004;11(1):35-50.
2004: Shankaran Harish; Neelamegham Sriram
Hydrodynamic forces applied on intercellular bonds, soluble molecules, and cell-surface receptors.
Biophysical journal 2004;86(1 Pt 1):576-88.
2003: Zhang Yi; Neelamegham Sriram
PPLATE: a computer program for analysis of parallel-plate flow chamber experimental data.
Journal of immunological methods 2003;278(1-2):319-21.
2003: Zhang Yi; Neelamegham Sriram
An analysis tool to quantify the efficiency of cell tethering and firm-adhesion in the parallel-plate flow chamber.
Journal of immunological methods 2003;278(1-2):305-17.
2003: Shankaran Harish; Alexandridis Paschalis; Neelamegham Sriram
Aspects of hydrodynamic shear regulating shear-induced platelet activation and self-association of von Willebrand factor in suspension.
Blood 2003;101(7):2637-45.
2002: Zhang Yi; Neelamegham Sriram
Estimating the efficiency of cell capture and arrest in flow chambers: study of neutrophil binding via E-selectin and ICAM-1.
Biophysical journal 2002;83(4):1934-52.
2002: Neelamegham Sriram; Matta Khushi L
Liposomes containing ligands. Binding specificity to selectins.
Methods in molecular biology (Clifton, N.J.) 2002;199():175-91.
2001: Ahmed F; Alexandridis P; Shankaran H; Neelamegham S
The ability of poloxamers to inhibit platelet aggregation depends on their physicochemical properties.
Thrombosis and haemostasis 2001;86(6):1532-9.
2001: Shankaran H; Neelamegham S
Nonlinear flow affects hydrodynamic forces and neutrophil adhesion rates in cone-plate viscometers.
Biophysical journal 2001;80(6):2631-48.
2001: Shankaran H; Neelamegham S
Effect of secondary flow on biological experiments in the cone-plate viscometer: methods for estimating collision frequency, wall shear stress and inter-particle interactions in non-linear flow.
Biorheology 2001;38(4):275-304.
2000: Neelamegham S; Taylor A D; Shankaran H; Smith C W; Simon S I
Shear and time-dependent changes in Mac-1, LFA-1, and ICAM-3 binding regulate neutrophil homotypic adhesion.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3798-805.
2000: Hentzen E R; Neelamegham S; Kansas G S; Benanti J A; McIntire L V; Smith C W; Simon S I
Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1.
Blood 2000;95(3):911-20.
1998: Lynam E; Sklar L A; Taylor A D; Neelamegham S; Edwards B S; Smith C W; Simon S I
Beta2-integrins mediate stable adhesion in collisional interactions between neutrophils and ICAM-1-expressing cells.
Journal of leukocyte biology 1998;64(5):622-30.
1998: Konstantopoulos K; Neelamegham S; Burns A R; Hentzen E; Kansas G S; Snapp K R; Berg E L; Hellums J D; Smith C W; McIntire L V; Simon S I
Venous levels of shear support neutrophil-platelet adhesion and neutrophil aggregation in blood via P-selectin and beta2-integrin.
Circulation 1998;98(9):873-82.
1998: Neelamegham S; Taylor A D; Burns A R; Smith C W; Simon S I
Hydrodynamic shear shows distinct roles for LFA-1 and Mac-1 in neutrophil adhesion to intercellular adhesion molecule-1.
Blood 1998;92(5):1626-38.
1998: Simon S I; Neelamegham S; Taylor A; Smith C W
The multistep process of homotypic neutrophil aggregation: a review of the molecules and effects of hydrodynamics.
Cell adhesion and communication 1998;6(2-3):263-76.
1997: Tsang Y T; Neelamegham S; Hu Y; Berg E L; Burns A R; Smith C W; Simon S I
Synergy between L-selectin signaling and chemotactic activation during neutrophil adhesion and transmigration.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4566-77.
1997: McIntyre B W; Woodside D G; Caruso D A; Wooten D K; Simon S I; Neelamegham S; Revelle J K; Vanderslice P
Regulation of human T lymphocyte coactivation with an alpha4 integrin antagonist peptide.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4180-6.
1997: Neelamegham S; Taylor A D; Hellums J D; Dembo M; Smith C W; Simon S I
Modeling the reversible kinetics of neutrophil aggregation under hydrodynamic shear.
Biophysical journal 1997;72(4):1527-40.
1996: Taylor A D; Neelamegham S; Hellums J D; Smith C W; Simon S I
Molecular dynamics of the transition from L-selectin- to beta 2-integrin-dependent neutrophil adhesion under defined hydrodynamic shear.
Biophysical journal 1996;71(6):3488-500.
1996: Neelamegham S; Simon S I; McIntyre B W; Zygourakis K
Induction of homotypic lymphocyte aggregation: evidence for a novel activation state of the beta1 integrin.
Journal of leukocyte biology 1996;59(6):872-82.

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