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Torben Neelands

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TOP 3
Xu-Feng Zhang; Michael F Jarvis; Steve McGaraughty; Carol S Surowy; Betty Yao; Di Zhang; Torben R Neelands
Development and validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel openers using QPatch HT.
Regina M Reilly; Robert G Schmidt; Jason A Segreti; Teresa M Turner; Eric A Voight; LaGeisha Lewis; Patrick W Mantyh; Heath A McDonald; Torben R Neelands; Madhavi Pai; Pamela S Puttfarcken; Jun Chen; Jerome F Daanen; Connie R Faltynek; Pamela H Franklin; Joseph R Ghilardi; Arthur Gomtsyan; Ping Han; Shailen K Joshi; Michael E Kort; Philip R Kym
Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature.
Xu-Feng Zhang; Ping Han; Prisca Honore; Steve McGaraughty; Torben R Neelands; Carol S Surowy; Di Zhang
Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel.

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All Publications

2013: Xu-Feng Zhang; Michael F Jarvis; Steve McGaraughty; Carol S Surowy; Betty Yao; Di Zhang; Torben R Neelands
Development and validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel openers using QPatch HT.
Assay and drug development technologies 2013;11(1):17-24.
2012: Regina M Reilly; Robert G Schmidt; Jason A Segreti; Teresa M Turner; Eric A Voight; LaGeisha Lewis; Patrick W Mantyh; Heath A McDonald; Torben R Neelands; Madhavi Pai; Pamela S Puttfarcken; Jun Chen; Jerome F Daanen; Connie R Faltynek; Pamela H Franklin; Joseph R Ghilardi; Arthur Gomtsyan; Ping Han; Shailen K Joshi; Michael E Kort; Philip R Kym
Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature.
The Journal of pharmacology and experimental therapeutics 2012;342(2):416-28.
2011: Xu-Feng Zhang; Ping Han; Prisca Honore; Steve McGaraughty; Torben R Neelands; Carol S Surowy; Di Zhang
Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel.
The Journal of general physiology 2011;138(3):341-52.
2011: Timothy A Vortherms; Di Zhang; Carol S Surowy; Andrew M Swensen; Rama Thimmapaya; C Brent Putman; Diana L Donnelly-Roberts; Richard S Janis; Michael F Jarvis; James T Limberis; Ruth L Martin; Marian T Namovic; Torben R Neelands; Wende Niforatos; Victoria E Scott
Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011;60(7):683-93.
2010: Pamela S Puttfarcken; Ping Han; Shailen K Joshi; Torben R Neelands; Donna M Gauvin; Scott J Baker; La Geisha R Lewis; Bruce R Bianchi; Joe Mikusa; John R Koenig; Richard J Perner; Michael E Kort; Prisca Honore; Connie R Faltynek; Philip R Kym; Regina M Reilly
A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model.
Pain 2010;150(2):319-26.
2010: Torben R Neelands; Xu-Feng Zhang; Heath McDonald; Pamela S Puttfarcken
Differential effects of temperature on acid-activated currents mediated by TRPV1 and ASIC channels in rat dorsal root ganglion neurons.
Brain research 2010;1329():55-66.
2009: Alla Korepanova; Ana Pereda-Lopez; Larry R Solomon; Karl A Walter; Marc R Lake; Bruce R Bianchi; Heath A McDonald; Torben R Neelands; Jianwei Shen; Edmund D Matayoshi; Robert B Moreland; Mark L Chiu
Expression and purification of human TRPV1 in baculovirus-infected insect cells for structural studies.
Protein expression and purification 2009;65(1):38-50.
2009: Prisca Honore; Prasant Chandran; Gricelda Hernandez; Donna M Gauvin; Joe Mikusa; Chengmin Zhong; Shailen K Joshi; Joseph R Ghilardi; Molly A Sevcik; Ryan M Fryer; Jason A Segreti; Patricia N Banfor; Kennan Marsh; Torben R Neelands; Erol Bayburt; Jerome F Daanen; Arthur Gomtsyan; Abel Lee; Michael E Kort; Regina M Reilly; Carol S Surowy; Philip R Kym; Patrick W Mantyh; James P Sullivan; Michael F Jarvis; Connie R Faltynek
Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia.
Pain 2009;142(1-2):27-35.
2008: Heath A McDonald; Torben R Neelands; Michael Kort; Ping Han; Melissa H Vos; Connie R Faltynek; Robert B Moreland; Pamela S Puttfarcken
Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia.
European journal of pharmacology 2008;596(1-3):62-9.
2008: Carol S Surowy; Torben R Neelands; Bruce R Bianchi; Steve McGaraughty; Rachid El Kouhen; Ping Han; Katharine L Chu; Heath A McDonald; Melissa Vos; Wende Niforatos; Erol K Bayburt; Arthur Gomtsyan; Abel Lee; Prisca Honore; James P Sullivan; Michael F Jarvis; Connie R Faltynek
(R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo.
The Journal of pharmacology and experimental therapeutics 2008;326(3):879-88.
2008: Jun Chen; Xu-Feng Zhang; Michael E Kort; Jeffrey R Huth; Chaohong Sun; Laura J Miesbauer; Steven C Cassar; Torben R Neelands; Victoria E Scott; Robert B Moreland; Regina M Reilly; Philip J Hajduk; Philip R Kym; Charles W Hutchins; Connie R Faltynek
Molecular determinants of species-specific activation or blockade of TRPA1 channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(19):5063-71.
2008: Xu-Feng Zhang; Jun Chen; Connie R Faltynek; Robert B Moreland; Torben R Neelands
Transient receptor potential A1 mediates an osmotically activated ion channel.
The European journal of neuroscience 2008;27(3):605-11.
2007: Bruce R Bianchi; Rachid El Kouhen; Torben R Neelands; Abel Lee; Arthur Gomtsyan; Shirish N Raja; Sriajan N Vaidyanathan; Bruce W Surber; Heath A McDonald; Carol S Surowy; Connie R Faltynek; Robert B Moreland; Michael F Jarvis; Pamela S Puttfarcken
[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor.
The Journal of pharmacology and experimental therapeutics 2007;323(1):285-93.
2007: Wende Niforatos; Xu-Feng Zhang; Marc R Lake; Karl A Walter; Torben R Neelands; Thomas F Holzman; Victoria E Scott; Connie R Faltynek; Robert B Moreland; Jun Chen
Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597).
Molecular pharmacology 2007;71(5):1209-16.
2006: Melissa H Vos; Torben R Neelands; Heath A McDonald; Won Choi; Paul Kroeger; Pamela S Puttfarcken; Connie R Faltynek; Robert B Moreland; Ping Han
TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells.
Journal of neurochemistry 2006;99(4):1088-102.
2006: M Cui; Prisca Honore; Chengmin Zhong; Donna M Gauvin; Joe Mikusa; Gricelda Hernandez; Prasant Chandran; Arthur Gomtsyan; B Brown; Erol K Bayburt; Kennan Marsh; Bruce R Bianchi; Heath McDonald; Wende Niforatos; Torben R Neelands; Robert B Moreland; Michael W Decker; Chih Hung Lee; James P Sullivan; Connie R Faltynek
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(37):9385-93.
2006: S K Joshi; Joe Mikusa; Gricelda Hernandez; Scott Baker; Char-Chang Shieh; Torben R Neelands; Xu-Feng Zhang; Wende Niforatos; Karen Kage; Ping Han; Douglas Krafte; Connie R Faltynek; James P Sullivan; Michael F Jarvis; Prisca Honore
Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states.
Pain 2006;123(1-2):75-82.
2005: Rama Thimmapaya; Torben R Neelands; Wende Niforatos; Rachel Davis-Taber; Won Choi; C Brent Putman; Paul Kroeger; jeremy packer; Murali Gopalakrishnan; Connie R Faltynek; Carol S Surowy; Victoria E Scott
Distribution and functional characterization of human Nav1.3 splice variants.
The European journal of neuroscience 2005;22(1):1-9.
2005: Rachid El Kouhen; Carol S Surowy; Bruce R Bianchi; Torben R Neelands; Heath A McDonald; Wende Niforatos; Arthur Gomtsyan; Abel Lee; Prisca Honore; James P Sullivan; Michael F Jarvis; Connie R Faltynek
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid.
The Journal of pharmacology and experimental therapeutics 2005;314(1):400-9.
2005: Svetlana Tertyshnikova; Ronald J Knox; Mary Jane Plym; George Thalody; Corinne Griffin; Torben R Neelands; David G Harden; Laura Signor; David Weaver; Robert A Myers; Nicholas J Lodge
BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties.
The Journal of pharmacology and experimental therapeutics 2005;313(1):250-9.
2005: Torben R Neelands; Michael F Jarvis; Ping Han; Connie R Faltynek; Carol S Surowy
Acidification of rat TRPV1 alters the kinetics of capsaicin responses.
Molecular pain 2005;1():28.
2003: Torben R Neelands; Edward C Burgard; Marie E Uchic; Heath A McDonald; Wende Niforatos; Connie R Faltynek; Kevin J Lynch; Michael F Jarvis
2', 3'-O-(2,4,6,trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X3 receptor.
British journal of pharmacology 2003;140(1):202-10.
2002: David Jacobson; Paco S Herson; Torben R Neelands; James Maylie; John P Adelman
SK channels are necessary but not sufficient for denervation-induced hyperexcitability.
Muscle & nerve 2002;26(6):817-22.
2001: Torben R Neelands; Paco S Herson; David Jacobson; John P Adelman; James Maylie
Small-conductance calcium-activated potassium currents in mouse hyperexcitable denervated skeletal muscle.
The Journal of physiology 2001;536(Pt 2):397-407.
2000: Torben R Neelands; Anthony King; Robert L Macdonald
Functional expression of L-, N-, P/Q-, and R-type calcium channels in the human NT2-N cell line.
Journal of neurophysiology 2000;84(6):2933-44.
2000: Chris T Bond; Rolf Sprengel; John M Bissonnette; Walter A Kaufmann; David Pribnow; Torben R Neelands; Thorsten Storck; M Baetscher; J Jerecic; James Maylie; Hans-Günther Knaus; Peter H Seeburg; John P Adelman
Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3.
Science (New York, N.Y.) 2000;289(5486):1942-6.
1999: J E Keen; R Khawaled; David L Farrens; Torben R Neelands; Andre F Rivard; Chris T Bond; Aaron Janowsky; Bernd Fakler; John P Adelman; James Maylie
Domains responsible for constitutive and Ca(2+)-dependent interactions between calmodulin and small conductance Ca(2+)-activated potassium channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(20):8830-8.
1999: Torben R Neelands; Robert L Macdonald
Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors.
Molecular pharmacology 1999;56(3):598-610.
1999: Torben R Neelands; J Zhang; Robert L Macdonald
GABA(A) receptors expressed in undifferentiated human teratocarcinoma NT2 cells differ from those expressed by differentiated NT2-N cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(16):7057-65.
1999: Torben R Neelands; Janet L Fisher; M Bianchi; Robert L Macdonald
Spontaneous and gamma-aminobutyric acid (GABA)-activated GABA(A) receptor channels formed by epsilon subunit-containing isoforms.
Molecular pharmacology 1999;55(1):168-78.
1998: Torben R Neelands; Lazar J Greenfield; J Zhang; Raymond Scott Turner; Robert L Macdonald
GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(13):4993-5007.
1998: D E Coling; S Bartolami; D Rhee; Torben R Neelands
Inhibition of calcium-dependent motility of cochlear outer hair cells by the protein kinase inhibitor, ML-9.
Hearing research 1998;115(1-2):175-83.
1997: N C Saxena; Torben R Neelands; Robert L Macdonald
Contrasting actions of lanthanum on different recombinant gamma-aminobutyric acid receptor isoforms expressed in L929 fibroblasts.
Molecular pharmacology 1997;51(2):328-35.
1997: Lazar J Greenfield; F Sun; Torben R Neelands; Edward C Burgard; J L Donnelly; Robert L Macdonald
Expression of functional GABAA receptors in transfected L929 cells isolated by immunomagnetic bead separation.
Neuropharmacology 1997;36(1):63-73.
1996: Edward C Burgard; E I Tietz; Torben R Neelands; Robert L Macdonald
Properties of recombinant gamma-aminobutyric acid A receptor isoforms containing the alpha 5 subunit subtype.
Molecular pharmacology 1996;50(1):119-27.