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Kenneth Neet

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Hrishikesh M Mehta; Sang B Woo; Kenneth E Neet
Comparison of nerve growth factor receptor binding models using heterodimeric muteins.
Suraporn Matragoon; Barbara A Mysona; Kenneth E Neet; Bindu A Pillai; Mohammed A Abdelsaid; Mohammed M H Al-Gayyar; Susan C Fagan; Azza B El-Remessy
Electroporation-mediated gene delivery of cleavage-resistant pro-nerve growth factor causes retinal neuro- and vascular degeneration.
Tahar Aboulkassim; Fouad Brahimi; Edith Hamel; Kenneth E Neet; Xin-Kang Tong; Tak Pan Wong; Sang B Woo; Yiu Chung Tse; H Uri Saragovi
Ligand-dependent TrkA activity in brain differentially affects spatial learning and long-term memory.

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All Publications

2012: Hrishikesh M Mehta; Sang B Woo; Kenneth E Neet
Comparison of nerve growth factor receptor binding models using heterodimeric muteins.
Journal of neuroscience research 2012;90(12):2259-71.
2012: Suraporn Matragoon; Barbara A Mysona; Kenneth E Neet; Bindu A Pillai; Mohammed A Abdelsaid; Mohammed M H Al-Gayyar; Susan C Fagan; Azza B El-Remessy
Electroporation-mediated gene delivery of cleavage-resistant pro-nerve growth factor causes retinal neuro- and vascular degeneration.
Molecular vision 2012;18():2993-3003.
2011: Tahar Aboulkassim; Fouad Brahimi; Edith Hamel; Kenneth E Neet; Xin-Kang Tong; Tak Pan Wong; Sang B Woo; Yiu Chung Tse; H Uri Saragovi
Ligand-dependent TrkA activity in brain differentially affects spatial learning and long-term memory.
Molecular pharmacology 2011;80(3):498-508.
2011: Yujing Bai; S Fabian Lerner; Kenneth E Neet; Delia Sivori; Sang B Woo; H Uri Saragovi
During glaucoma, alpha2-macroglobulin accumulates in aqueous humor and binds to nerve growth factor, neutralizing neuroprotection.
Investigative ophthalmology & visual science 2011;52(8):5260-5.
2010: Yujing Bai; Pauline Dergham; Hinyu Nedev; Jing Xu; Alba Galan; Jose Carlos Rivera; Shi ZhiHua; Hrishikesh M Mehta; Sang B Woo; Marinko V Sarunic; Kenneth E Neet; H Uri Saragovi
Chronic and acute models of retinal neurodegeneration TrkA activity are neuroprotective whereas p75NTR activity is neurotoxic through a paracrine mechanism.
The Journal of biological chemistry 2010;285(50):39392-400.
2010: Mary-Louise Rogers; Sheree Bailey; Dusan Matusica; Ian Nicholson; Hakan Muyderman; Promila C Pagadala; Kenneth E Neet; Heddy Zola; Peter J Macardle; Robert A Rush
ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex.
Journal of neuroimmunology 2010;226(1-2):93-103.
2009: Sidharth Mahapatra; Hrishikesh Mehta; Sang B Woo; Kenneth E Neet
Identification of critical residues within the conserved and specificity patches of nerve growth factor leading to survival or differentiation.
The Journal of biological chemistry 2009;284(48):33600-13.
2009: Raheleh Masoudi; Maria S Ioannou; Michael D Coughlin; Promila Pagadala; Kenneth E Neet; Oliver Clewes; Shelley J Allen; David Dawbarn; Margaret Fahnestock
Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors.
The Journal of biological chemistry 2009;284(27):18424-33.
2008: Kenneth E Neet; Gopal Thinakaran
Thematic minireview series on the molecular basis of Alzheimer disease.
The Journal of biological chemistry 2008;283(44):29613-4.
2008: Jacqueline Boutilier; Claire Ceni; Promila C Pagdala; Alison Forgie; Kenneth E Neet; Philip A Barker
Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation.
The Journal of biological chemistry 2008;283(19):12709-16.
2007: Ljubica Ivanisevic; WenHua Zheng; Sang B Woo; Kenneth E Neet; H Uri Saragovi
TrkA receptor "hot spots" for binding of NT-3 as a heterologous ligand.
The Journal of biological chemistry 2007;282(23):16754-63.
2006: Promila C Pagadala; Laura A Dvorak; Kenneth E Neet
Construction of a mutated pro-nerve growth factor resistant to degradation and suitable for biophysical and cellular utilization.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17939-43.
2004: Houman Vaghefi; Kenneth E Neet
Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation.
Oncogene 2004;23(49):8078-87.
2004: Houman Vaghefi; Allison L Hughes; Kenneth E Neet
Nerve growth factor withdrawal-mediated apoptosis in naive and differentiated PC12 cells through p53/caspase-3-dependent and -independent pathways.
The Journal of biological chemistry 2004;279(15):15604-14.
2003: Shivanand P Lad; Kenneth E Neet; Elliott J Mufson
Nerve growth factor: structure, function and therapeutic implications for Alzheimer's disease.
Current drug targets. CNS and neurological disorders 2003;2(5):315-34.
2003: Shivanand P Lad; Kenneth E Neet
Activation of the mitogen-activated protein kinase pathway through p75NTR: a common mechanism for the neurotrophin family.
Journal of neuroscience research 2003;73(5):614-26.
2003: Shivanand P Lad; Daniel A Peterson; Ralph A Bradshaw; Kenneth E Neet
Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site.
The Journal of biological chemistry 2003;278(27):24808-17.
2003: Todd C Pappas; Francesco Decorti; Nancy J Macdonald; Kenneth E Neet; Giulio Taglialatela
Tumour necrosis factor-alpha- vs. growth factor deprivation-promoted cell death: different receptor requirements for mediating nerve growth factor-promoted rescue.
Aging cell 2003;2(2):83-92.
2002: Kenneth E Neet; J Ching Lee
Biophysical characterization of proteins in the post-genomic era of proteomics.
Molecular & cellular proteomics : MCP 2002;1(6):415-20.
2001: Gregory M Ross; Igor L Shamovsky; Sang B Woo; Joan I Post; P N Vrkljan; Gail M Lawrance; Mark Solc; Suzanne Dostaler; Kenneth E Neet; Richard J Riopelle
The binding of zinc and copper ions to nerve growth factor is differentially affected by pH: implications for cerebral acidosis.
Journal of neurochemistry 2001;78(3):515-23.
2001: Kenneth E Neet; R B Campenot
Receptor binding, internalization, and retrograde transport of neurotrophic factors.
Cellular and molecular life sciences : CMLS 2001;58(8):1021-35.
2001: A L Hughes; D Messineo-Jones; Shivanand P Lad; Kenneth E Neet
Distinction between differentiation, cell cycle, and apoptosis signals in PC12 cells by the nerve growth factor mutant delta9/13, which is selective for the p75 neurotrophin receptor.
Journal of neuroscience research 2001;63(1):10-9.
1998: H Uri Saragovi; W Zheng; S Maliartchouk; G M DiGugliemo; Yogesh Mawal; A Kamen; Sang B Woo; A Claudio Cuello; T Debeir; Kenneth E Neet
A TrkA-selective, fast internalizing nerve growth factor-antibody complex induces trophic but not neuritogenic signals.
The Journal of biological chemistry 1998;273(52):34933-40.
1998: Kenneth E Neet
Enzyme catalytic power minireview series.
The Journal of biological chemistry 1998;273(40):25527-8.
1998: Sang B Woo; C Whalen; Kenneth E Neet
Characterization of the recombinant extracellular domain of the neurotrophin receptor TrkA and its interaction with nerve growth factor (NGF).
Protein science : a publication of the Protein Society 1998;7(4):1006-16.
1996: Sang B Woo; Kenneth E Neet
Characterization of histidine residues essential for receptor binding and activity of nerve growth factor.
The Journal of biological chemistry 1996;271(40):24433-41.
1995: X Z Campbell; Kenneth E Neet
Hierarchical analysis of the nerve growth factor-dependent and nerve growth factor-independent differentiation signaling pathways in PC12 cells with protein kinase inhibitors.
Journal of neuroscience research 1995;42(2):207-19.
1995: Sang B Woo; D E Timm; Kenneth E Neet
Alteration of NH2-terminal residues of nerve growth factor affects activity and Trk binding without affecting stability or conformation.
The Journal of biological chemistry 1995;270(11):6278-85.
1994: Kenneth E Neet; D E Timm
Conformational stability of dimeric proteins: quantitative studies by equilibrium denaturation.
Protein science : a publication of the Protein Society 1994;3(12):2167-74.
1994: D E Timm; P L de Haseth; Kenneth E Neet
Comparative equilibrium denaturation studies of the neurotrophins: nerve growth factor, brain-derived neurotrophic factor, neurotrophin 3, and neurotrophin 4/5.
Biochemistry 1994;33(15):4667-76.
1994: D E Timm; A H Ross; Kenneth E Neet
Circular dichroism and crosslinking studies of the interaction between four neurotrophins and the extracellular domain of the low-affinity neurotrophin receptor.
Protein science : a publication of the Protein Society 1994;3(3):451-8.
1994: J Nanduri; S M Vroegop; Stephen Buxser; Kenneth E Neet
Immunological determinants of nerve growth factor involved in p140trk (Trk) receptor binding.
Journal of neuroscience research 1994;37(4):433-44.
1994: K R Singh; L K Taylor; X Z Campbell; A P Fields; Kenneth E Neet
A bryostatin-sensitive protein kinase C required for nerve growth factor activity.
Biochemistry 1994;33(2):542-51.
1994: M T Kasaian; James Jacobberger; Kenneth E Neet
Flow cytometric analysis of fluorescein-labeled nerve growth factor binding to A875 human melanoma cells.
Experimental cell research 1994;210(1):77-85.
1993: M A Kumar; D E Timm; Kenneth E Neet; W G Owen; W J Peumans; A G Rao
Characterization of the lectin from the bulbs of Eranthis hyemalis (winter aconite) as an inhibitor of protein synthesis.
The Journal of biological chemistry 1993;268(33):25176-83.
1992: M E Karpen; P L de Haseth; Kenneth E Neet
Differences in the amino acid distributions of 3(10)-helices and alpha-helices.
Protein science : a publication of the Protein Society 1992;1(10):1333-42.
1992: D E Timm; P Vissavajjhala; A H Ross; Kenneth E Neet
Spectroscopic and chemical studies of the interaction between nerve growth factor (NGF) and the extracellular domain of the low affinity NGF receptor.
Protein science : a publication of the Protein Society 1992;1(8):1023-31.
1992: Y Luo; Kenneth E Neet
The unprocessed C-terminal dipeptide of recombinant beta-nerve growth factor determines three stable forms with distinct biological activities.
The Journal of biological chemistry 1992;267(17):12275-83.
1992: D E Timm; Kenneth E Neet
Equilibrium denaturation studies of mouse beta-nerve growth factor.
Protein science : a publication of the Protein Society 1992;1(2):236-44.
1990: M T Kasaian; Kenneth E Neet
A comparison of nerve growth factor binding protocols with native and mutant PC12 cells.
Neurochemical research 1990;15(12):1167-74.
1990: M E Karpen; Kenneth E Neet; P L de Haseth
A common pentapeptide conformation occurs in viral acid proteases and other proteins.
Journal of molecular biology 1990;216(2):201-6.
1990: David M Katz; M Erb; R Lillis; Kenneth E Neet
Trophic regulation of nodose ganglion cell development: evidence for an expanded role of nerve growth factor during embryogenesis in the rat.
Experimental neurology 1990;110(1):1-10.
1990: S X Lin; Kenneth E Neet
Demonstration of a slow conformational change in liver glucokinase by fluorescence spectroscopy.
The Journal of biological chemistry 1990;265(17):9670-5.
1990: Kenneth E Neet; R P Keenan; P S Tippett
Observation of a kinetic slow transition in monomeric glucokinase.
Biochemistry 1990;29(3):770-7.
1989: M T Kasaian; Kenneth E Neet
Nerve growth factor in human amniotic and cerebrospinal fluid.
BioFactors (Oxford, England) 1989;2(2):99-104.
1989: S X Lin; W K Vogel; Kenneth E Neet
Stoichiometry of slow binding of palmitoyl-CoA to liver glucokinase.
International journal of peptide and protein research 1989;34(4):333-9.
1989: W K Vogel; R P Keenan; C W Gelev; Kenneth E Neet
The regulatory kinetic properties of porcine hepatic glucokinase.
Molecular and cellular biochemistry 1989;86(2):171-9.
1989: D S Reinhold; Kenneth E Neet
The lack of a role for protein kinase C in neurite extension and in the induction of ornithine decarboxylase by nerve growth factor in PC12 cells.
The Journal of biological chemistry 1989;264(6):3538-44.
1989: M E Karpen; P L de Haseth; Kenneth E Neet
Comparing short protein substructures by a method based on backbone torsion angles.
Proteins 1989;6(2):155-67.
1988: M T Kasaian; Kenneth E Neet
Internalization of nerve growth factor by PC12 cells. A description of cellular pools.
The Journal of biological chemistry 1988;263(11):5083-90.
1984: A G Rao; Kenneth E Neet
Subunit interactions of 7 S nerve growth factor. Gamma-esterase activity, rates, and conformational changes during reassociation.
The Journal of biological chemistry 1984;259(1):73-9.
1983: P S Tippett; Kenneth E Neet
Interconversions between different sulfhydryl-related kinetic states in glucokinase.
Archives of biochemistry and biophysics 1983;222(1):285-98.
1982: A G Rao; Kenneth E Neet
Tryptophan residues of the gamma subunit of 7S nerve growth factor: intrinsic fluorescence, solute quenching, and N-bromosuccinimide oxidation.
Biochemistry 1982;21(26):6843-50.
1982: P S Tippett; Kenneth E Neet
An allosteric model for the inhibition of glucokinase by long chain acyl coenzyme A.
The Journal of biological chemistry 1982;257(21):12846-52.
1982: P S Tippett; Kenneth E Neet
Specific inhibition of glucokinase by long chain acyl coenzymes A below the critical micelle concentration.
The Journal of biological chemistry 1982;257(21):12839-45.