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Masahiko Negishi

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Kosuke Saito; Rick Moore; Masahiko Negishi
Nuclear receptor CAR specifically activates the two-pore K+ channel Kcnk1 gene in male mouse livers, which attenuates phenobarbital-induced hepatic hyperplasia.
Shingo Mutoh; Rick Moore; Lee Pedersen; Lalith Perera; Mack Sobhany; Tatsuya Sueyoshi; Masahiko Negishi
Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling.
Mack Sobhany; Nobuo Sugiura; Y Kakuta; Koji Kimata; Masahiko Negishi
The structural basis for a coordinated reaction catalyzed by a bifunctional glycosyltransferase in chondroitin biosynthesis.

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All Publications

2013: Kosuke Saito; Rick Moore; Masahiko Negishi
Nuclear receptor CAR specifically activates the two-pore K+ channel Kcnk1 gene in male mouse livers, which attenuates phenobarbital-induced hepatic hyperplasia.
Toxicological sciences : an official journal of the Society of Toxicology 2013;132(1):151-61.
2013: Shingo Mutoh; Rick Moore; Lee Pedersen; Lalith Perera; Mack Sobhany; Tatsuya Sueyoshi; Masahiko Negishi
Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling.
Science signaling 2013;6(274):ra31.
2012: Mack Sobhany; Nobuo Sugiura; Y Kakuta; Koji Kimata; Masahiko Negishi
The structural basis for a coordinated reaction catalyzed by a bifunctional glycosyltransferase in chondroitin biosynthesis.
The Journal of biological chemistry 2012;287(43):36022-8.
2012: Sawako Shindo; Masahiko Negishi; Tsutomu Sakuma; James Squires
Phosphorylation of serine 212 confers novel activity to human estrogen receptor α.
Steroids 2012;77(5):448-53.
2011: Yuichi Yamazaki; Rick Moore; Masahiko Negishi
Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver.
Laboratory investigation; a journal of technical methods and pathology 2011;91(11):1624-33.
2011: Makoto Osabe; Masahiko Negishi
Active ERK1/2 protein interacts with the phosphorylated nuclear constitutive active/androstane receptor (CAR; NR1I3), repressing dephosphorylation and sequestering CAR in the cytoplasm.
The Journal of biological chemistry 2011;286(41):35763-9.
2011: Susumu Kodama; Joyce A Goldstein; Fardin Hosseinpour; Masahiko Negishi
Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure.
Nucleic acids research 2011;39(19):8392-403.
2011: Hiroki Kamino; Rick Moore; Masahiko Negishi
Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines.
Cancer genetics 2011;204(7):382-91.
2011: Hiroki Kamino; Yuichi Yamazaki; Kosuke Saito; Daichi Takizawa; Satoru Kakizaki; Rick Moore; Masahiko Negishi
Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors.
International journal of oncology 2011;38(6):1511-20.
2011: Susumu Kodama; Masahiko Negishi
Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.
The Journal of biological chemistry 2011;286(5):3570-8.
2011: Tatsuya Sueyoshi; Kellie Vinal; Tyler S Woodrum; William D Green; Rick Moore; Masahiko Negishi
Garlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver.
PloS one 2011;6(6):e21229.
2010: Yoshihiro Konno; Hiroki Kamino; Rick Moore; Fred Lih; Kenneth B Tomer; Darryl C Zeldin; Joyce A Goldstein; Masahiko Negishi
The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(7):1177-82.
2010: Yukio Yamamoto; Rick Moore; Richard A Flavell; Binfeng Lu; Masahiko Negishi
Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B.
PloS one 2010;5(4):e10121.
2010: Yoshihiro Konno; Rick Moore; Nobuhiro Kamiya; Masahiko Negishi
Nuclear xenobiotic receptor PXR-null mouse exhibits hypophosphatemia and represses the Na/Pi-cotransporter SLC34A2.
Pharmacogenetics and genomics 2010;20(1):9-17.
2009: Jennifer E Adair; Vandy Stober; Mack Sobhany; Lisheng Zhuo; John D Roberts; Masahiko Negishi; Koji Kimata; Stavros Garantziotis
Inter-alpha-trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin binding.
The Journal of biological chemistry 2009;284(25):16922-30.
2009: Kaoru Inoue; Masahiko Negishi
Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4alpha.
FEBS letters 2009;583(12):2126-30.
2009: Yoshihiro Konno; Susumu Kodama; Rick Moore; Nobuhiro Kamiya; Masahiko Negishi
Nuclear xenobiotic receptor pregnane X receptor locks corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) onto the CYP24A1 promoter to attenuate vitamin D3 activation.
Molecular pharmacology 2009;75(2):265-71.
2008: Mack Sobhany; Y Kakuta; Nobuo Sugiura; Koji Kimata; Masahiko Negishi
The chondroitin polymerase K4CP and the molecular mechanism of selective bindings of donor substrates to two active sites.
The Journal of biological chemistry 2008;283(47):32328-33.
2008: Yukio Yamamoto; Masahiko Negishi
The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(7):1189-93.
2008: Makoto Osabe; Junko Sugatani; Akiko Takemura; Yasuhiro Yamazaki; Akira Ikari; Naomi Kitamura; Masahiko Negishi; Masao Miwa
Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation.
Biochemical and biophysical research communications 2008;369(4):1027-33.
2008: Kaoru Inoue; Masahiko Negishi
Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 2B6 gene.
The Journal of biological chemistry 2008;283(16):10425-32.
2008: Tatsuya Sueyoshi; Rick Moore; Junko Sugatani; Yonehiro Matsumura; Masahiko Negishi
PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor.
Molecular pharmacology 2008;73(4):1113-21.
2008: Yoshihiro Konno; Masahiko Negishi; Susumu Kodama
The roles of nuclear receptors CAR and PXR in hepatic energy metabolism.
Drug metabolism and pharmacokinetics 2008;23(1):8-13.
2007: Susumu Kodama; Rick Moore; Yukio Yamamoto; Masahiko Negishi
Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene.
The Biochemical journal 2007;407(3):373-81.
2007: Fardin Hosseinpour; Yoav Timsit; Chika Koike; Kenji Matsui; Yukio Yamamoto; Rick Moore; Masahiko Negishi
Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver.
FEBS letters 2007;581(25):4937-42.
2007: Chika Koike; Rick Moore; Masahiko Negishi
Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes.
Molecular pharmacology 2007;71(5):1217-21.
2007: Kouichi Nakamura; Rick Moore; Masahiko Negishi; Tatsuya Sueyoshi
Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver.
The Journal of biological chemistry 2007;282(13):9768-76.
2007: Yoav E Timsit; Masahiko Negishi
CAR and PXR: the xenobiotic-sensing receptors.
Steroids 2007;72(3):231-46.
2007: Eric S Tien; Kenji Matsui; Rick Moore; Masahiko Negishi
The nuclear receptor constitutively active/androstane receptor regulates type 1 deiodinase and thyroid hormone activity in the regenerating mouse liver.
The Journal of pharmacology and experimental therapeutics 2007;320(1):307-13.
2006: Jonathan P Jackson; Stephen S Ferguson; Masahiko Negishi; Joyce A Goldstein
Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(12):2003-10.
2006: E S Tien; Masahiko Negishi
Nuclear receptors CAR and PXR in the regulation of hepatic metabolism.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(10-11):1152-63.
2006: Kaoru Inoue; Christoph H Borchers; Masahiko Negishi
Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics.
The Biochemical journal 2006;398(1):125-33.
2006: Yukio Yamamoto; Rick Moore; Holly A Hess; Grace L Guo; Frank J Gonzalez; Kenneth S Korach; Robert R Maronpot; Masahiko Negishi
Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity.
The Journal of biological chemistry 2006;281(24):16625-31.
2006: Fardin Hosseinpour; Rick Moore; Masahiko Negishi; Tatsuya Sueyoshi
Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor.
Molecular pharmacology 2006;69(4):1095-102.
2006: Mack Sobhany; Masahiko Negishi
Characterization of specific donor binding to alpha1,4-N-acetylhexosaminyltransferase EXTL2 using isothermal titration calorimetry.
Methods in enzymology 2006;416():3-12.
2006: Susumu Kodama; Masahiko Negishi
Phenobarbital confers its diverse effects by activating the orphan nuclear receptor car.
Drug metabolism reviews 2006;38(1-2):75-87.
2005: Chika Koike; Rick Moore; Masahiko Negishi
Localization of the nuclear receptor CAR at the cell membrane of mouse liver.
FEBS letters 2005;579(30):6733-6.
2005: Stephen S Ferguson; Yuping Chen; Edward LeCluyse; Masahiko Negishi; Joyce A Goldstein
Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.
Molecular pharmacology 2005;68(3):747-57.
2005: Mack Sobhany; Jian Dong; Masahiko Negishi
Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase.
The Journal of biological chemistry 2005;280(25):23441-5.
2005: Akiko Ueda; Kenji Matsui; Yukio Yamamoto; Lars C Pedersen; Tatsuya Sueyoshi; Masahiko Negishi
Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR.
The Biochemical journal 2005;388(Pt 2):623-30.
2005: Junko Sugatani; Shinichi Nishitani; Kasumi Yamakawa; Kouichi Yoshinari; Tatsuya Sueyoshi; Masahiko Negishi; Masao Miwa
Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1.
Molecular pharmacology 2005;67(3):845-55.
2005: Karen Swales; Satoru Kakizaki; Yukio Yamamoto; Kaoru Inoue; Kaoru Kobayashi; Masahiko Negishi
Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells.
The Journal of biological chemistry 2005;280(5):3458-66.
2005: Junko Sugatani; Tatsuya Sueyoshi; Masahiko Negishi; Masao Miwa
Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocorticoid receptor.
Methods in enzymology 2005;400():92-104.
2004: E James Squires; Tatsuya Sueyoshi; Masahiko Negishi
Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.
The Journal of biological chemistry 2004;279(47):49307-14.
2004: Andrea F Moon; Suzanne C Edavettal; Joseph M Krahn; Eva M Munoz; Masahiko Negishi; Robert J Linhardt; Jian Liu; Lars C Pedersen
Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1.
The Journal of biological chemistry 2004;279(43):45185-93.
2004: Yukio Yamamoto; Rick Moore; Thomas L Goldsworthy; Masahiko Negishi; Robert R Maronpot
The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice.
Cancer research 2004;64(20):7197-200.
2004: Susumu Kodama; Chika Koike; Masahiko Negishi; Yukio Yamamoto
Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.
Molecular and cellular biology 2004;24(18):7931-40.
2004: Karen Swales; Masahiko Negishi
CAR, driving into the future.
Molecular endocrinology (Baltimore, Md.) 2004;18(7):1589-98.
2004: Suzanne C Edavettal; Karen A Lee; Masahiko Negishi; Robert J Linhardt; Jian Liu; Lars C Pedersen
Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1.
The Journal of biological chemistry 2004;279(24):25789-97.
2004: Jonathan P Jackson; Stephen S Ferguson; Rick Moore; Masahiko Negishi; Joyce A Goldstein
The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29.
Molecular pharmacology 2004;65(6):1397-404.
2004: Yuping Chen; Stephen S Ferguson; Masahiko Negishi; Joyce A Goldstein
Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor.
The Journal of pharmacology and experimental therapeutics 2004;308(2):495-501.
2003: Kaoru Inoue; Mack Sobhany; Thomas R Transue; Keiji Oguma; Lars C Pedersen; Masahiko Negishi
Structural analysis by X-ray crystallography and calorimetry of a haemagglutinin component (HA1) of the progenitor toxin from Clostridium botulinum.
Microbiology (Reading, England) 2003;149(Pt 12):3361-70.
2003: Karen A Lee; Hirotoshi Fuda; Young C Lee; Masahiko Negishi; Charles A Strott; Lars C Pedersen
Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms.
The Journal of biological chemistry 2003;278(45):44593-9.
2003: Kaoru Kobayashi; Tatsuya Sueyoshi; Kaoru Inoue; Rick Moore; Masahiko Negishi
Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells.
Molecular pharmacology 2003;64(5):1069-75.
2003: Yuping Chen; Stephen S Ferguson; Masahiko Negishi; Joyce A Goldstein
Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter.
Molecular pharmacology 2003;64(2):316-24.
2003: Kouichi Yoshinari; Kaoru Kobayashi; Rick Moore; Takeshi Kawamoto; Masahiko Negishi
Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital.
FEBS letters 2003;548(1-3):17-20.
2003: Sergei Shevtsov; Evgeniy V Petrotchenko; Lars C Pedersen; Masahiko Negishi
Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase.
Environmental health perspectives 2003;111(7):884-8.
2003: Lars C Pedersen; Jian Dong; Fumiyasu Taniguchi; Hiroshi Kitagawa; Joseph M Krahn; Lee G Pedersen; Kazuyuki Sugahara; Masahiko Negishi
Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis.
The Journal of biological chemistry 2003;278(16):14420-8.
2003: Masahiko Negishi; Jian Dong; Thomas A Darden; Lee G Pedersen; Lars C Pedersen
Glucosaminylglycan biosynthesis: what we can learn from the X-ray crystal structures of glycosyltransferases GlcAT1 and EXTL2.
Biochemical and biophysical research communications 2003;303(2):393-8.
2003: Y Kakuta; L Li; Lars C Pedersen; Lee G Pedersen; Masahiko Negishi
Heparan sulphate N-sulphotransferase activity: reaction mechanism and substrate recognition.
Biochemical Society transactions 2003;31(2):331-4.
2003: Satoru Kakizaki; Yukio Yamamoto; Akiko Ueda; Rick Moore; Tatsuya Sueyoshi; Masahiko Negishi
Phenobarbital induction of drug/steroid-metabolizing enzymes and nuclear receptor CAR.
Biochimica et biophysica acta 2003;1619(3):239-42.
2003: Anna Gorokhov; Masahiko Negishi; Eric F Johnson; Lars C Pedersen; Lalith Perera; Thomas A Darden; Lee G Pedersen
Explicit water near the catalytic I helix Thr in the predicted solution structure of CYP2A4.
Biophysical journal 2003;84(1):57-68.
2003: Yukio Yamamoto; Takeshi Kawamoto; Masahiko Negishi
The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity.
Archives of biochemistry and biophysics 2003;409(1):207-11.
2002: Stephen S Ferguson; Edward LeCluyse; Masahiko Negishi; Joyce A Goldstein
Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.
Molecular pharmacology 2002;62(3):737-46.
2002: Lars C Pedersen; Thomas A Darden; Masahiko Negishi
Crystal structure of beta 1,3-glucuronyltransferase I in complex with active donor substrate UDP-GlcUA.
The Journal of biological chemistry 2002;277(24):21869-73.
2002: Akiko Ueda; Satoru Kakizaki; Masahiko Negishi; Tatsuya Sueyoshi
Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR.
Molecular pharmacology 2002;61(6):1284-8.
2002: Lars C Pedersen; Evgeniy V Petrotchenko; Sergei Shevtsov; Masahiko Negishi
Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction.
The Journal of biological chemistry 2002;277(20):17928-32.
2002: Junko Sugatani; Kasumi Yamakawa; Kouichi Yoshinari; Takashi Machida; Hitoshi Takagi; Masatomo Mori; Satoru Kakizaki; Tatsuya Sueyoshi; Masahiko Negishi; Masao Miwa
Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia.
Biochemical and biophysical research communications 2002;292(2):492-7.
2002: Satoru Kakizaki; Sohrab Karami; Masahiko Negishi
Retinoic acids repress constitutive active receptor-mediated induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene of the CYP2B10 gene in mouse primary hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(2):208-11.
2002: Tatsuya Sueyoshi; Rick Moore; Jean-Marc Pascussi; Masahiko Negishi
Direct expression of fluorescent protein-tagged nuclear receptor CAR in mouse liver.
Methods in enzymology 2002;357():205-13.
2002: Akiko Ueda; Hisham K Hamadeh; Heather K Webb; Yukio Yamamoto; Tatsuya Sueyoshi; Cynthia A Afshari; Jurgen Lehmann; Masahiko Negishi
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital.
Molecular pharmacology 2002;61(1):1-6.
2001: Masahiko Negishi; Lee G Pedersen; Evgeniy V Petrotchenko; Sergei Shevtsov; Anna Gorokhov; Y Kakuta; Lars C Pedersen
Structure and function of sulfotransferases.
Archives of biochemistry and biophysics 2001;390(2):149-57.
2001: D Blizard; Tatsuya Sueyoshi; Masahiko Negishi; Shangara S Dehal; David Kupfer
Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(6):781-5.
2001: Junko Sugatani; H Kojima; Akiko Ueda; Satoru Kakizaki; Kouichi Yoshinari; Q H Gong; Ida S Owens; Masahiko Negishi; Tatsuya Sueyoshi
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.
Hepatology (Baltimore, Md.) 2001;33(5):1232-8.
2001: I Zelko; Tatsuya Sueyoshi; Takeshi Kawamoto; Rick Moore; Masahiko Negishi
The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver.
Molecular and cellular biology 2001;21(8):2838-46.
2001: Evgeniy V Petrotchenko; Lars C Pedersen; Christoph H Borchers; Kenneth B Tomer; Masahiko Negishi
The dimerization motif of cytosolic sulfotransferases.
FEBS letters 2001;490(1-2):39-43.
2001: Kouichi Yoshinari; Tatsuya Sueyoshi; Rick Moore; Masahiko Negishi
Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYB2B1 gene by phenobarbital in rat livers.
Molecular pharmacology 2001;59(2):278-84.
2001: K Yoshinari; Evgeniy V Petrotchenko; Lars C Pedersen; Masahiko Negishi
Crystal structure-based studies of cytosolic sulfotransferase.
Journal of biochemical and molecular toxicology 2001;15(2):67-75.
2001: Tatsuya Sueyoshi; Masahiko Negishi
Phenobarbital response elements of cytochrome P450 genes and nuclear receptors.
Annual review of pharmacology and toxicology 2001;41():123-43.
2000: Anna Gorokhov; Lalith Perera; Thomas A Darden; Masahiko Negishi; Lars C Pedersen; Lee G Pedersen
Heparan sulfate biosynthesis: a theoretical study of the initial sulfation step by N-deacetylase/N-sulfotransferase.
Biophysical journal 2000;79(6):2909-17.
2000: Lars C Pedersen; K Tsuchida; H Kitagawa; K Sugahara; Thomas A Darden; Masahiko Negishi
Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I.
The Journal of biological chemistry 2000;275(44):34580-5.
2000: Takeshi Kawamoto; Satoru Kakizaki; Kouichi Yoshinari; Masahiko Negishi
Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene.
Molecular endocrinology (Baltimore, Md.) 2000;14(11):1897-905.
2000: I Zelko; Masahiko Negishi
Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes.
Biochemical and biophysical research communications 2000;277(1):1-6.
2000: Lars C Pedersen; Evgeniy V Petrotchenko; Masahiko Negishi
Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase.
FEBS letters 2000;475(1):61-4.
1999: Evgeniy V Petrotchenko; M E Doerflein; Y Kakuta; Lars C Pedersen; Masahiko Negishi
Substrate gating confers steroid specificity to estrogen sulfotransferase.
The Journal of biological chemistry 1999;274(42):30019-22.
1999: Tatsuya Sueyoshi; N Yokomori; Kenneth S Korach; Masahiko Negishi
Developmental action of estrogen receptor-alpha feminizes the growth hormone-Stat5b pathway and expression of Cyp2a4 and Cyp2d9 genes in mouse liver.
Molecular pharmacology 1999;56(3):473-7.
1999: Takeshi Kawamoto; Tatsuya Sueyoshi; I Zelko; Rick Moore; K Washburn; Masahiko Negishi
Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene.
Molecular and cellular biology 1999;19(9):6318-22.
1999: Y Kakuta; Tatsuya Sueyoshi; Masahiko Negishi; Lars C Pedersen
Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1.
The Journal of biological chemistry 1999;274(16):10673-6.
1999: Tatsuya Sueyoshi; Takeshi Kawamoto; I Zelko; Paavo Honkakoski; Masahiko Negishi
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene.
The Journal of biological chemistry 1999;274(10):6043-6.
1998: Y Kakuta; Evgeniy V Petrotchenko; Lars C Pedersen; Masahiko Negishi
The sulfuryl transfer mechanism. Crystal structure of a vanadate complex of estrogen sulfotransferase and mutational analysis.
The Journal of biological chemistry 1998;273(42):27325-30.
1998: Paavo Honkakoski; I Zelko; Tatsuya Sueyoshi; Masahiko Negishi
The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene.
Molecular and cellular biology 1998;18(10):5652-8.
1998: Tatsuya Sueyoshi; Y Kakuta; Lars C Pedersen; F E Wall; Lee G Pedersen; Masahiko Negishi
A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase.
FEBS letters 1998;433(3):211-4.
1998: Y Kakuta; Lee G Pedersen; Lars C Pedersen; Masahiko Negishi
Conserved structural motifs in the sulfotransferase family.
Trends in biochemical sciences 1998;23(4):129-30.
1998: Paavo Honkakoski; Rick Moore; K A Washburn; Masahiko Negishi
Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene.
Molecular pharmacology 1998;53(4):597-601.
1998: I Zelko; R Kobayashi; Paavo Honkakoski; Masahiko Negishi
Molecular cloning and characterization of a novel nuclear protein kinase in mice.
Archives of biochemistry and biophysics 1998;352(1):31-6.
1998: Y Kakuta; Lars C Pedersen; K Chae; W C Song; DA LeBlanc; R London; Charles Carter; Masahiko Negishi
Mouse steroid sulfotransferases: substrate specificity and preliminary X-ray crystallographic analysis.
Biochemical pharmacology 1998;55(3):313-7.
1998: Paavo Honkakoski; Masahiko Negishi
Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes.
Journal of biochemical and molecular toxicology 1998;12(1):3-9.
1997: Paavo Honkakoski; Masahiko Negishi
The structure, function, and regulation of cytochrome P450 2A enzymes.
Drug metabolism reviews 1997;29(4):977-96.
1997: Shuanfang Li; K A Washburn; Rick Moore; T Uno; Christina Teng; Retha R Newbold; john alan mclachlan; Masahiko Negishi
Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus.
Cancer research 1997;57(19):4356-9.
1997: N Yokomori; K Nishio; K Aida; Masahiko Negishi
Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.
The Journal of steroid biochemistry and molecular biology 1997;62(4):307-14.
1997: Paavo Honkakoski; Masahiko Negishi
Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene.
The Journal of biological chemistry 1997;272(23):14943-9.
1996: Masahiko Negishi; T Uno; Thomas A Darden; Tatsuya Sueyoshi; Lee G Pedersen
Structural flexibility and functional versatility of mammalian P450 enzymes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(7):683-9.
1996: Paavo Honkakoski; Rick Moore; J Gynther; Masahiko Negishi
Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes.
The Journal of biological chemistry 1996;271(16):9746-53.
1996: Masahiko Negishi; M Iwasaki; R O Juvonen; Tatsuya Sueyoshi; Thomas A Darden; Lee G Pedersen
Structural flexibility and functional versatility of cytochrome P450 and rapid evolution.
Mutation research 1996;350(1):43-50.
1996: Masahiko Negishi; T Uno; Paavo Honkakoski; Tatsuya Sueyoshi; Thomas A Darden; L P Pedersen
The roles of individual amino acids in altering substrate specificity of the P450 2a4/2a5 enzymes.
Biochimie 1996;78(8-9):685-94.
1995: N Yokomori; R Kobayashi; Rick Moore; Tatsuya Sueyoshi; Masahiko Negishi
A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.
Molecular and cellular biology 1995;15(10):5355-62.
1995: Tatsuya Sueyoshi; L J Park; Rick Moore; R O Juvonen; Masahiko Negishi
Molecular engineering of microsomal P450 2a-4 to a stable, water-soluble enzyme.
Archives of biochemistry and biophysics 1995;322(1):265-71.
1995: Tatsuya Sueyoshi; R Kobayashi; K Nishio; K Aida; Rick Moore; T Wada; H Handa; Masahiko Negishi
A nuclear factor (NF2d9) that binds to the male-specific P450 (Cyp 2d-9) gene in mouse liver.
Molecular and cellular biology 1995;15(8):4158-66.
1995: W C Song; R Moore; john alan mclachlan; Masahiko Negishi
Molecular characterization of a testis-specific estrogen sulfotransferase and aberrant liver expression in obese and diabetogenic C57BL/KsJ-db/db mice.
Endocrinology 1995;136(6):2477-84.
1995: M Iwasaki; Thomas A Darden; Lee G Pedersen; Masahiko Negishi
Altering the regiospecificity of androstenedione hydroxylase activity in P450s 2a-4/5 by a mutation of the residue at position 481.
Biochemistry 1995;34(15):5054-9.
1995: N Yokomori; Rick Moore; Masahiko Negishi
Sexually dimorphic DNA demethylation in the promoter of the Slp (sex-limited protein) gene in mouse liver.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1302-6.
1995: M Iwasaki; D G Davis; Thomas A Darden; Lee G Pedersen; Masahiko Negishi
Multiple steroid-binding orientations: alteration of regiospecificity of dehydroepiandrosterone 2- and 7-hydroxylase activities of cytochrome P-450 2a-5 by mutation of residue 209.
The Biochemical journal 1995;306 ( Pt 1)():29-33.
1994: M Iwasaki; Thomas A Darden; Carol Parker; Kenneth B Tomer; Lee G Pedersen; Masahiko Negishi
Inherent versatility of P-450 oxygenase. Conferring dehydroepiandrosterone hydroxylase activity to P-450 2a-4 by a single amino acid mutation at position 117.
The Journal of biological chemistry 1994;269(12):9079-83.
1994: K Aida; Rick Moore; Masahiko Negishi
Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.
Genomics 1994;19(3):564-6.
1993: K Aida; Masahiko Negishi
A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.
Journal of molecular endocrinology 1993;11(2):213-22.
1993: R O Juvonen; M Iwasaki; Tatsuya Sueyoshi; Masahiko Negishi
Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.
The Biochemical journal 1993;294 ( Pt 1)():31-4.
1993: M Iwasaki; R L Lindberg; R O Juvonen; Masahiko Negishi
Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.
The Biochemical journal 1993;291 ( Pt 2)():569-73.
1993: M Iwasaki; Thomas A Darden; Lee G Pedersen; D G Davis; R O Juvonen; Tatsuya Sueyoshi; Masahiko Negishi
Engineering mouse P450coh to a novel corticosterone 15 alpha-hydroxylase and modeling steroid-binding orientation in the substrate pocket.
The Journal of biological chemistry 1993;268(2):759-62.
1992: R O Juvonen; M Iwasaki; Masahiko Negishi
Roles of residues 129 and 209 in the alteration by cytochrome b5 of hydroxylase activities in mouse 2A P450S.
Biochemistry 1992;31(46):11519-23.
1992: R L Lindberg; R Juvonen; Masahiko Negishi
Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.
Pharmacogenetics 1992;2(1):32-7.
1991: R O Juvonen; M Iwasaki; Masahiko Negishi
Structural function of residue-209 in coumarin 7-hydroxylase (P450coh). Enzyme-kinetic studies and site-directed mutagenesis.
The Journal of biological chemistry 1991;266(25):16431-5.
1991: K Aida; Masahiko Negishi
Posttranscriptional regulation of coumarin 7-hydroxylase induction by xenobiotics in mouse liver: mRNA stabilization by pyrazole.
Biochemistry 1991;30(32):8041-5.
1991: M Iwasaki; R Juvonen; R Lindberg; Masahiko Negishi
Alteration of high and low spin equilibrium by a single mutation of amino acid 209 in mouse cytochromes P450.
The Journal of biological chemistry 1991;266(6):3380-2.
1991: M Lakso; R Masaki; M Noshiro; Masahiko Negishi
Structures and characterization of sex-specific mouse cytochrome P-450 genes as members within a large family. Duplication boundary and evolution.
European journal of biochemistry / FEBS 1991;195(2):477-86.
1990: H Yoshioka; M Lang; G Wong; Masahiko Negishi
A specific cis-acting element regulates in vitro transcription of sex-dependent mouse steroid 16 alpha-hydroxylase (C-P450(16 alpha)) gene.
The Journal of biological chemistry 1990;265(24):14612-7.
1990: H Yoshioka; R Lindberg; G Wong; T Ichikawa; T Itakura; B Burkhart; Masahiko Negishi
Characterization and regulation of sex-specific mouse steroid hydroxylase genes.
Canadian journal of physiology and pharmacology 1990;68(6):754-61.
1990: B A Burkhart; L C Skow; Masahiko Negishi
Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.
Gene 1990;87(2):205-11.
1990: H N Yeowell; P D McClellan-Green; Masahiko Negishi; Joyce A Goldstein
Characterization of a cDNA for the unexpressed form of cytochrome P-450g from the (-g) rat and differentiation of its mRNA from that of the (+g) phenotype using specific oligoprobes.
Biochemistry 1990;29(3):713-8.
1989: P D McClellan-Green; Masahiko Negishi; Joyce A Goldstein
Characterization of a cDNA for rat P-450g, a highly polymorphic, male-specific cytochrome in the P-450IIC subfamily.
Biochemistry 1989;28(14):5832-9.
1989: R L Lindberg; Masahiko Negishi
Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.
Nature 1989;339(6226):632-4.
1989: T Ichikawa; T Itakura; Masahiko Negishi
Functional characterization of two cytochrome P-450s within the mouse, male-specific steroid 16 alpha-hydroxylase gene family: expression in mammalian cells and chimeric proteins.
Biochemistry 1989;28(11):4779-84.
1989: Masahiko Negishi; R Lindberg; B Burkhart; T Ichikawa; Paavo Honkakoski; M Lang
Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.
Biochemistry 1989;28(10):4169-72.
1989: R Lindberg; B Burkhart; T Ichikawa; Masahiko Negishi
The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.
The Journal of biological chemistry 1989;264(11):6465-71.
1989: G Wong; T Itakura; K Kawajiri; L Skow; Masahiko Negishi
Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization.
The Journal of biological chemistry 1989;264(5):2920-7.
1988: N Harada; Masahiko Negishi
Substrate specificities of cytochrome P-450, C-P-450(16)alpha and P-450(15)alpha, and contribution to steroid hydroxylase activities in mouse liver microsomes.
Biochemical pharmacology 1988;37(24):4778-80.
1988: M Noshiro; Masahiko Negishi
Genetic regulation of estrogen-dependent repression of female-specific testosterone 16 alpha-hydroxylase (I-P-450(16 alpha) in male mouse liver: murine Ripr locus.
Biochemistry 1988;27(17):6444-8.
1988: M Noshiro; M Lakso; K Kawajiri; Masahiko Negishi
Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.
Biochemistry 1988;27(17):6434-43.
1988: E J Squires; Masahiko Negishi
Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.
The Journal of biological chemistry 1988;263(9):4166-71.
1988: R Gasser; Masahiko Negishi; RM Philpot
Primary structures of multiple forms of cytochrome P-450 isozyme 2 derived from rabbit pulmonary and hepatic cDNAs.
Molecular pharmacology 1988;33(1):22-30.
1987: G Wong; K Kawajiri; Masahiko Negishi
Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16) alpha) in mouse liver: cDNA sequences, neonatal imprinting, and reversible regulation by androgen.
Biochemistry 1987;26(26):8683-90.