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Lucia Negri

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Milena De Felice; Pietro Melchiorri; Michael H Ossipov; Frank Porreca; Todd W Vanderah; Lucia Negri
Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression.
Lucia Negri; Roberta Lattanzi
Bv8/PK2 and prokineticin receptors: a druggable pronociceptive system.
Rossella Miele; Roberta Lattanzi; Maria Carmela Bonaccorsi di Patti; Alessandro Paiardini; Lucia Negri; Donatella Barra
Expression of Bv8 in Pichia pastoris to identify structural features for receptor binding.

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All Publications

2012: Milena De Felice; Pietro Melchiorri; Michael H Ossipov; Frank Porreca; Todd W Vanderah; Lucia Negri
Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression.
Neuroscience letters 2012;521(1):40-5.
2012: Lucia Negri; Roberta Lattanzi
Bv8/PK2 and prokineticin receptors: a druggable pronociceptive system.
Current opinion in pharmacology 2012;12(1):62-6.
2010: Rossella Miele; Roberta Lattanzi; Maria Carmela Bonaccorsi di Patti; Alessandro Paiardini; Lucia Negri; Donatella Barra
Expression of Bv8 in Pichia pastoris to identify structural features for receptor binding.
Protein expression and purification 2010;73(1):10-4.
2009: Elisa Giannini; Roberta Lattanzi; Annalisa Nicotra; Antonio F Campese; Paola Grazioli; Isabella Screpanti; Gianfranco Balboni; Severo Salvadori; Paola Sacerdote; Lucia Negri
The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14646-51.
2009: Steven Ballet; Debby Feytens; Rien De Wachter; Magali De Vlaeminck; Ewa D Marczak; Severo Salvadori; Chris de Graaf; Didier Rognan; Lucia Negri; Roberta Lattanzi; Lawrence H Lazarus; Dirk Tourwé; Gianfranco Balboni
Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.
Bioorganic & medicinal chemistry letters 2009;19(2):433-7.
2008: Gianfranco Balboni; Ilaria Lazzari; Claudio Trapella; Lucia Negri; Roberta Lattanzi; Elisa Giannini; Annalisa Nicotra; Pietro Melchiorri; Sergio Visentin; Chiara De Nuccio; Severo Salvadori
Triazine compounds as antagonists at Bv8-prokineticin receptors.
Journal of medicinal chemistry 2008;51(23):7635-9.
2008: Silvia Franchi; Elisa Giannini; Donatella Lattuada; Roberta Lattanzi; Hui Tian; Pietro Melchiorri; Lucia Negri; Alberto E Panerai; Paola Sacerdote
The prokineticin receptor agonist Bv8 decreases IL-10 and IL-4 production in mice splenocytes by activating prokineticin receptor-1.
BMC immunology 2008;9():60.
2007: Vito de Novellis; Lucia Negri; Roberta Lattanzi; Francesca Rossi; Enza Palazzo; Ida Marabese; Elisa Giannini; Daniela Vita; Pietro Melchiorri; Sabatino Maione
The prokineticin receptor agonist Bv8 increases GABA release in the periaqueductal grey and modifies RVM cell activities and thermoceptive reflexes in the rat.
The European journal of neuroscience 2007;26(11):3068-78.
2007: Severo Salvadori; Claudio Trapella; Stella Fiorini; Lucia Negri; Roberta Lattanzi; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Gianfranco Balboni
A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic.
Bioorganic & medicinal chemistry 2007;15(22):6876-81.
2007: Lucia Negri; Roberta Lattanzi; Elisa Giannini; Pietro Melchiorri
Bv8/Prokineticin proteins and their receptors.
Life sciences 2007;81(14):1103-16.
2007: Laura Biondi; Fernando Filira; Elisa Giannini; Marina Gobbo; Roberta Lattanzi; Lucia Negri; Raniero Rocchi
Novel glycosylated [Lys(7)]-dermorphin analogues: synthesis, biological activity and conformational investigations.
Journal of peptide science : an official publication of the European Peptide Society 2007;13(3):179-89.
2006: Francesco E Pontieri; Roberta Lattanzi; Dario Benincasa; Michele Cavallari; Lucia Negri; Francesco Orzi
Effects of the intravenous administration of [Lys7]dermorphin on local cerebral glucose utilization in the rat.
European journal of pharmacology 2006;544(1-3):17-20.
2006: Lucia Negri; Roberta Lattanzi; Elisa Giannini; Pietro Melchiorri
Modulators of pain: Bv8 and prokineticins.
Current neuropharmacology 2006;4(3):207-15.
2006: Steven Ballet; Severo Salvadori; Claudio Trapella; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Lucia Negri; Elisa Giannini; Roberta Lattanzi; Dirk Tourwé; Gianfranco Balboni
New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.
Journal of medicinal chemistry 2006;49(13):3990-3.
2006: Lucia Negri; Roberta Lattanzi; Elisa Giannini; Mariantonella Colucci; Federica Margheriti; Pietro Melchiorri; Vittorio Vellani; Hui Tian; Milena De Felice; Frank Porreca
Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(25):6716-27.
2006: M. Eugenio Vázquez; Juan B Blanco; Severo Salvadori; Claudio Trapella; Roberto Argazzi; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Lucia Negri; Elisa Giannini; Roberta Lattanzi; Mariantonella Colucci; Gianfranco Balboni
6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.
Journal of medicinal chemistry 2006;49(12):3653-8.
2006: Vittorio Vellani; Mariantonella Colucci; Roberta Lattanzi; Elisa Giannini; Lucia Negri; Pietro Melchiorri; Peter A McNaughton
Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(19):5109-16.
2006: Cataldo Martucci; Silvia Franchi; Elisa Giannini; Hui Tian; Pietro Melchiorri; Lucia Negri; Paola Sacerdote
Bv8, the amphibian homologue of the mammalian prokineticins, induces a proinflammatory phenotype of mouse macrophages.
British journal of pharmacology 2006;147(2):225-34.
2005: Gianfranco Balboni; Remo Guerrini; Severo Salvadori; Lucia Negri; Elisa Giannini; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
Journal of medicinal chemistry 2005;48(26):8112-4.
2005: Lucia Negri; Roberta Lattanzi; Elisa Giannini; Mariantonella Colucci; Giuseppina Mignogna; Donatella Barra; Fabio Grohovaz; Franca Codazzi; Alessandra Kaiser; Günther Kreil; Pietro Melchiorri
Biological activities of Bv8 analogues.
British journal of pharmacology 2005;146(5):625-32.
2005: Roberta Lattanzi; Mariana Spetea; Falko Schüllner; Silvia B Rief; Roland Krassnig; Lucia Negri; Helmut Schmidhammer
Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities.
Journal of medicinal chemistry 2005;48(9):3372-8.
2004: Gianfranco Balboni; Severo Salvadori; Alessandro Dal Piaz; Fabrizio Bortolotti; Roberto Argazzi; Lucia Negri; Roberta Lattanzi; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic.
Journal of medicinal chemistry 2004;47(26):6541-6.
2004: Laura Biondi; Elisa Giannini; Fernando Filira; Marina Gobbo; Lucia Negri; Raniero Rocchi
[D-Ala2]-Deltorphin I peptoid and retropeptoid analogues: synthesis, biological activity and conformational investigations.
Journal of peptide science : an official publication of the European Peptide Society 2004;10(9):578-87.
2004: Gianfranco Balboni; Severo Salvadori; Remo Guerrini; Lucia Negri; Elisa Giannini; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism.
Journal of medicinal chemistry 2004;47(16):4066-71.
2004: Antonella D'Ambrosio; Lia Noviello; Lucia Negri; Helmut Schmidhammer; Francesca Quintieri
Effect of novel non-peptidic delta opioid receptor antagonists on human T and B cell activation.
Life sciences 2004;75(1):63-75.
2004: Lucia Negri; Roberta Lattanzi; Elisa Giannini; Milena De Felice; Antonella Colucci; Pietro Melchiorri
Bv8, the amphibian homologue of the mammalian prokineticins, modulates ingestive behaviour in rats.
British journal of pharmacology 2004;142(1):181-91.
2003: Gianfranco Balboni; Severo Salvadori; Remo Guerrini; Lucia Negri; Elisa Giannini; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism.
Bioorganic & medicinal chemistry 2003;11(24):5435-41.
2003: Laura Biondi; Elisa Giannini; Fernando Filira; Marina Gobbo; Mauro Marastoni; Lucia Negri; Barbara Scolaro; Roberto Tomatisc; Raniero Rocchi
Synthesis, conformation and biological activity of dermorphin and deltorphin I analogues containing N-alkylglycine in place of residues in position 1, 3, 5 and 6.
Journal of peptide science : an official publication of the European Peptide Society 2003;9(10):638-48.
2003: Fernando Filira; Barbara Biondi; Laura Biondi; Elisa Giannini; Marina Gobbo; Lucia Negri; Raniero Rocchi
Opioid peptides: synthesis and biological properties of [(N gamma-glucosyl,N gamma-methoxy)-alpha, gamma-diamino-(S)-butanoyl]4-deltorphin-1-neoglycopeptide and related analogues.
Organic & biomolecular chemistry 2003;1(17):3059-63.
2002: Gianfranco Balboni; Severo Salvadori; Remo Guerrini; Lucia Negri; Elisa Giannini; Yunden Jinsmaa; Sharon D Bryant; Lawrence H Lazarus
Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.
Journal of medicinal chemistry 2002;45(25):5556-63.
2002: Lucia Negri; Roberta Lattanzi; Elisa Giannini; Alessio Metere; Mariantonella Colucci; Donatella Barra; Günther Kreil; Pietro Melchiorri
Nociceptive sensitization by the secretory protein Bv8.
British journal of pharmacology 2002;137(8):1147-54.
2002: Roberta Lattanzi; Lucia Negri; Helmut Schmidhammer; Elisa Giannini
Antinociceptive activity of a novel buprenorphine analogue.
Life sciences 2002;70(18):2177-85.
2001: Roberta Lattanzi; Lucia Negri; Elisa Giannini; Helmut Schmidhammer; J Schutz; Giovanna Improta
HS-599: a novel long acting opioid analgesic does not induce place-preference in rats.
British journal of pharmacology 2001;134(2):441-7.
2001: Rafael Maldonado; Cinzia Severini; H W D Matthes; Jerome Becker; Pietro Melchiorri; Lucia Negri
Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene.
British journal of pharmacology 2001;132(7):1485-92.
2001: Susan Slowe; Siân Clarke; I Lena; Robin J Goody; Roberta Lattanzi; Lucia Negri; Frédéric Simonin; H W D Matthes; Dominique Filliol; Jerome Becker; Ian Kitchen
Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of mu-, delta- or kappa-opioid receptor knockout mice.
Neuroscience 2001;106(3):469-80.
2000: Lucia Negri; Pietro Melchiorri; Roberta Lattanzi
Pharmacology of amphibian opiate peptides.
Peptides 2000;21(11):1639-47.
1999: Lucia Negri; Maria Broccardo; Roberta Lattanzi; Pietro Melchiorri
Effects of antisense oligonucleotides on brain delta-opioid receptor density and on SNC80-induced locomotor stimulation and colonic transit inhibition in rats.
British journal of pharmacology 1999;128(7):1554-60.
1999: C Mollay; C Wechselberger; Giuseppina Mignogna; Lucia Negri; Pietro Melchiorri; Donatella Barra; Günther Kreil
Bv8, a small protein from frog skin and its homologue from snake venom induce hyperalgesia in rats.
European journal of pharmacology 1999;374(2):189-96.
1999: Lucia Negri; Roberta Lattanzi; Anna Borsodi; G Toth; Severo Salvadori
Differential knockdown of delta-opioid receptor subtypes in the rat brain by antisense oligodeoxynucleotides targeting mRNA.
Antisense & nucleic acid drug development 1999;9(2):203-11.
1999: Lucia Negri; Roberta Lattanzi; Fabio Tabacco; L Orrù; Cinzia Severini; Barbara Scolaro; Raniero Rocchi
Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.
Journal of medicinal chemistry 1999;42(3):400-4.
1998: H W D Matthes; C Smadja; O Valverde; Jean-Luc Vonesch; Arthur S Foutz; Eliane Boudinot; Monique Denavit-Saubié; Cinzia Severini; Lucia Negri; Bernard P Roques; Rafael Maldonado; Jerome Becker
Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(18):7285-95.
1998: Lucia Negri; Roberta Lattanzi; Fabio Tabacco; Barbara Scolaro; Raniero Rocchi
Glycodermorphins: opioid peptides with potent and prolonged analgesic activity and enhanced blood-brain barrier penetration.
British journal of pharmacology 1998;124(7):1516-22.
1998: C Wechselberger; Cinzia Severini; Günther Kreil; Lucia Negri
A new opioid peptide predicted from cloned cDNAs from skin of Pachymedusa dacnicolor and Agalychnis annae.
FEBS letters 1998;429(1):41-3.
1998: Lucia Negri; Roberta Lattanzi; Fabio Tabacco; Pietro Melchiorri
Respiratory and cardiovascular effects of the mu-opioid receptor agonist [Lys7]dermorphin in awake rats.
British journal of pharmacology 1998;124(2):345-55.
1997: L Noviello; S Papadia; M R Capobianchi; Lucia Negri
Immunomodulatory responses to delta-opioid receptor ligands in human lymphocytes.
European journal of pharmacology 1997;332(2):R1-2.
1997: Lucia Negri; Cinzia Severini; Roberta Lattanzi; Rosa Luisa Potenza; Pietro Melchiorri
Postnatal development of delta-opioid receptor subtypes in mice.
British journal of pharmacology 1997;120(6):989-94.
1996: Pietro Melchiorri; Lucia Negri
The dermorphin peptide family.
General pharmacology 1996;27(7):1099-107.
1996: Lucia Negri; L Noviello; V Noviello
Antinociceptive and behavioral effects of synthetic deltorphin analogs.
European journal of pharmacology 1996;296(1):9-16.
1996: Lucia Negri; Pietro Melchiorri; Raniero Rocchi; Barbara Scolaro
Opioid receptor affinity and analgesic activity of O- and C-glycosylated opioid peptides.
Acta physiologica Hungarica 1996;84(4):441-3.
1995: Lucia Negri; Giovanna Improta; Roberta Lattanzi; R L Potenza; F Luchetti; Pietro Melchiorri
Interaction between the mu-agonist dermorphin and the delta-agonist [D-Ala2, Glu4]deltorphin in supraspinal antinociception and delta-opioid receptor binding.
British journal of pharmacology 1995;116(7):2931-8.
1995: Lucia Negri; Roberta Lattanzi; Pietro Melchiorri
Production of antinociception by peripheral administration of [Lys7]dermorphin, a naturally occurring peptide with high affinity for mu-opioid receptors.
British journal of pharmacology 1995;114(1):57-66.
1994: Donatella Barra; Giuseppina Mignogna; Maurizio Simmaco; Piero Pucci; Cinzia Severini; Giuliana Falconieri-Erspamer; Lucia Negri; Vittorio Erspamer
[D-Leu2]deltorphin, a 17 amino acid opioid peptide from the skin of the Brazilian hylid frog, Phyllomedusa burmeisteri.
Peptides 1994;15(2):199-202.
1993: Tindaro G Renda; Lucia Negri; I Tooyama; C Casu; Pietro Melchiorri
Autoradiographic study on [3H]-[D-Ala2]-deltorphin-I binding sites in the rat brain.
Neuroreport 1993;4(10):1143-6.
1992: Lucia Negri; G F Erspamer; Cinzia Severini; R L Potenza; Pietro Melchiorri; Vittorio Erspamer
Dermorphin-related peptides from the skin of Phyllomedusa bicolor and their amidated analogs activate two mu opioid receptor subtypes that modulate antinociception and catalepsy in the rat.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):7203-7.
1992: Giuseppina Mignogna; Cinzia Severini; Maurizio Simmaco; Lucia Negri; G F Erspamer; Günther Kreil; Donatella Barra
Identification and characterization of two dermorphins from skin extracts of the Amazonian frog Phyllomedusa bicolor.
FEBS letters 1992;302(2):151-4.
1992: Pietro Melchiorri; M Maritati; Lucia Negri; Vittorio Erspamer
Long-term sensitization to the activation of cerebral delta-opioid receptors by the deltorphin Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2 in rats exposed to morphine.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):3696-700.
1991: Lucia Negri; V Noviello; F Angelucci
Behavioural effects of deltorphins in rats.
European journal of pharmacology 1991;209(3):163-8.
1991: Lucia Negri; R L Potenza; R Corsi; Pietro Melchiorri
Evidence for two subtypes of delta opioid receptors in rat brain.
European journal of pharmacology 1991;196(3):335-6.
1991: Pietro Melchiorri; Lucia Negri; Giuliana Falconieri-Erspamer; Cinzia Severini; R Corsi; M Soaje; Vittorio Erspamer; Donatella Barra
Structure-activity relationships of the delta-opioid-selective agonists, deltorphins.
European journal of pharmacology 1991;195(2):201-7.
1990: K Richter; R Egger; Lucia Negri; R Corsi; Cinzia Severini; Günther Kreil
cDNAs encoding [D-Ala2]deltorphin precursors from skin of Phyllomedusa bicolor also contain genetic information for three dermorphin-related opioid peptides.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4836-9.
1989: Vittorio Erspamer; Pietro Melchiorri; Giuliana Falconieri-Erspamer; Lucia Negri; R Corsi; Cinzia Severini; Donatella Barra; Maurizio Simmaco; Günther Kreil
Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):5188-92.
1989: Günther Kreil; Donatella Barra; Maurizio Simmaco; Vittorio Erspamer; G F Erspamer; Lucia Negri; Cinzia Severini; R Corsi; Pietro Melchiorri
Deltorphin, a novel amphibian skin peptide with high selectivity and affinity for delta opioid receptors.
European journal of pharmacology 1989;162(1):123-8.
1988: Lucia Negri; Giovanna Improta; Maria Broccardo; Pietro Melchiorri
Phyllolitorins: a new family of bombesin-like peptides.
Annals of the New York Academy of Sciences 1988;547():415-28.
1985: Lucia Negri; L Noviello; V Noviello
Effects of sauvagine, urotensin I and CRF on food intake in rats.
Peptides 1985;6 Suppl 3():53-7.
1981: Lucia Negri; Pietro Melchiorri; G F Erspamer; Vittorio Erspamer
Radioimmunoassay of dermorphin-like peptides in mammalian and non-mammalian tissues.
Peptides 1981;2 Suppl 2():45-9.
1981: Vittorio Erspamer; Pietro Melchiorri; Maria Broccardo; G F Erspamer; Paolo Falaschi; G Improota; Lucia Negri; Tindaro G Renda
The brain-gut-skin triangle: new peptides.
Peptides 1981;2 Suppl 2():7-16.
1980: Vittorio Erspamer; G F Erspamer; Giovanna Improta; Lucia Negri; R de Castiglione
Sauvagine, a new polypeptide from Phyllomedusa sauvagei skin. Occurrence in various Phyllomedusa species and pharmacological actions on rat blood pressure and diuresis.
Naunyn-Schmiedeberg's archives of pharmacology 1980;312(3):265-70.
1980: T Nakajima; T Yasuhara; Vittorio Erspamer; G F Erspamer; Lucia Negri; R Endean
Physalaemin- and bombesin-like peptides in the skin of the Australian leptodactylid frog Uperoleia rugosa.
Chemical & pharmaceutical bulletin 1980;28(3):689-95.