Stephen Neidle

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Hsu Shang-Te Danny; Varnai Peter; Bugaut Anthony; Reszka Anthony P; Neidle Stephen; Balasubramanian Shankar
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.
Cuenca Francisco; Moore Michael J B; Johnson Karin; Guyen Bérangère; De Cian Anne; Neidle Stephen
Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells.
Rahman Khondaker M; Reszka Anthony P; Gunaratnam Mekala; Haider Shozeb M; Howard Philip W; Fox Keith R; Neidle Stephen; Thurston David E
Biaryl polyamides as a new class of DNA quadruplex-binding ligands.

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All Publications

2009: Hsu Shang-Te Danny; Varnai Peter; Bugaut Anthony; Reszka Anthony P; Neidle Stephen; Balasubramanian Shankar
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.
Journal of the American Chemical Society 2009;131(37):13399-409.
2009: Cuenca Francisco; Moore Michael J B; Johnson Karin; Guyen Bérangère; De Cian Anne; Neidle Stephen
Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells.
Bioorganic & medicinal chemistry letters 2009;19(17):5109-13.
2009: Rahman Khondaker M; Reszka Anthony P; Gunaratnam Mekala; Haider Shozeb M; Howard Philip W; Fox Keith R; Neidle Stephen; Thurston David E
Biaryl polyamides as a new class of DNA quadruplex-binding ligands.
Chemical communications (Cambridge, England) 2009;(27):4097-9.
2009: Gunaratnam Mekala; Green Colin; Moreira João Bruno; Moorhouse Adam D; Kelland Lloyd R; Moses John E; Neidle Stephen
G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo.
Biochemical pharmacology 2009;78(2):115-22.
2009: Balasubramanian Shankar; Neidle Stephen
G-quadruplex nucleic acids as therapeutic targets.
Current opinion in chemical biology 2009;13(3):345-53.
2009: Neidle Stephen
The structures of quadruplex nucleic acids and their drug complexes.
Current opinion in structural biology 2009;19(3):239-50.
2009: Gunaratnam Mekala; Swank Stephen; Haider Shozeb M; Galesa Katja; Reszka Anthony P; Beltran Monica; Cuenca Francisco; Fletcher Jonathan A; Neidle Stephen
Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.
Journal of medicinal chemistry 2009;52(12):3774-83.
2009: Haider Shozeb M; Neidle Stephen
A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes.
Biochemical Society transactions 2009;37(Pt 3):583-8.
2009: Nguyen Binh; Neidle Stephen; Wilson W David
A role for water molecules in DNA-ligand minor groove recognition.
Accounts of chemical research 2009;42(1):11-21.
2008: Drewe William C; Neidle Stephen
Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers.
Chemical communications (Cambridge, England) 2008;(42):5295-7.
2008: Zagotto Giuseppe; Sissi Claudia; Lucatello Lorena; Pivetta Claudia; Cadamuro Sergio A; Fox Keith R; Neidle Stephen; Palumbo Manlio
Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation.
Journal of medicinal chemistry 2008;51(18):5566-74.
2008: Parkinson Gary N; Cuenca Francisco; Neidle Stephen
Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes.
Journal of molecular biology 2008;381(5):1145-56.
2008: Reed Julie; Gunaratnam Mekala; Beltran Monica; Reszka Anthony P; Vilar Ramon; Neidle Stephen
TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules.
Analytical biochemistry 2008;380(1):99-105.
2008: Neidle Stephen; Parkinson Gary N
Quadruplex DNA crystal structures and drug design.
Biochimie 2008;90(8):1184-96.
2008: Haider Shozeb; Parkinson Gary N; Neidle Stephen
Molecular dynamics and principal components analysis of human telomeric quadruplex multimers.
Biophysical journal 2008;95(1):296-311.
2008: Moorhouse Adam D; Haider Shozeb; Gunaratnam Mekala; Munnur Deeksha; Neidle Stephen; Moses John E
Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands.
Molecular bioSystems 2008;4(6):629-42.
2008: Campbell Nancy H; Parkinson Gary N; Reszka Anthony P; Neidle Stephen
Structural basis of DNA quadruplex recognition by an acridine drug.
Journal of the American Chemical Society 2008;130(21):6722-4.
2008: Todd Alan K; Neidle Stephen
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements.
Nucleic acids research 2008;36(8):2700-4.
2008: Cuenca Francisco; Greciano Olga; Gunaratnam Mekala; Haider Shozeb; Munnur Deeksha; Nanjunda Rupesh; Wilson W David; Neidle Stephen
Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.
Bioorganic & medicinal chemistry letters 2008;18(5):1668-73.
2007: Gunaratnam Mekala; Greciano Olga; Martins Cristina; Reszka Anthony P; Schultes Christoph M; Morjani Hamid; Riou Jean-Francois; Neidle Stephen
Mechanism of acridine-based telomerase inhibition and telomere shortening.
Biochemical pharmacology 2007;74(5):679-89.
2007: Lee Michael P H; Parkinson Gary N; Hazel Pascale; Neidle Stephen
Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel.
Journal of the American Chemical Society 2007;129(33):10106-7.
2007: Munde Manoj; Lee Michael; Neidle Stephen; Arafa Reem; Boykin David W; Liu Yang; Bailly Christian; Wilson W David
Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex.
Journal of the American Chemical Society 2007;129(17):5688-98.
2007: Martins Cristina; Gunaratnam Mekala; Stuart John; Makwana Vaidahi; Greciano Olga; Reszka Anthony P; Kelland Lloyd R; Neidle Stephen
Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.
Bioorganic & medicinal chemistry letters 2007;17(8):2293-8.
2007: Parkinson Gary N; Ghosh Ragini; Neidle Stephen
Structural basis for binding of porphyrin to human telomeres.
Biochemistry 2007;46(9):2390-7.
2007: White Elizabeth W; Tanious Farial; Ismail Mohamed A; Reszka Anthony P; Neidle Stephen; Boykin David W; Wilson W David
Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge.
Biophysical chemistry 2007;126(1-3):140-53.
2007: Todd Alan K; Haider Shozeb M; Parkinson Gary N; Neidle Stephen
Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter.
Nucleic acids research 2007;35(17):5799-808.
2007: Milroy Lech-Gustav; Zinzalla Giovanna; Prencipe Giuseppe; Michel Patrick; Ley Steven V; Gunaratnam Mekala; Beltran Monica; Neidle Stephen
Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives.
Angewandte Chemie (International ed. in English) 2007;46(14):2493-6.
2006: Moorhouse Adam D; Santos Ana Mafalda; Gunaratnam Mekala; Moore Michael; Neidle Stephen; Moses John E
Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry.
Journal of the American Chemical Society 2006;128(50):15972-3.
2006: Redman James E; Ladame Sylvain; Reszka Anthony P; Neidle Stephen; Balasubramanian Shankar
Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library.
Organic & biomolecular chemistry 2006;4(23):4364-9.
2006: Moore Michael J B; Cuenca Francisco; Searcey Mark; Neidle Stephen
Synthesis of distamycin A polyamides targeting G-quadruplex DNA.
Organic & biomolecular chemistry 2006;4(18):3479-88.
2006: Evans David A; Neidle Stephen
Virtual screening of DNA minor groove binders.
Journal of medicinal chemistry 2006;49(14):4232-8.
2006: Fernando Himesh; Reszka Anthony P; Huppert Julian; Ladame Sylvain; Rankin Sarah; Venkitaraman Ashok R; Neidle Stephen; Balasubramanian Shankar
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene.
Biochemistry 2006;45(25):7854-60.
2006: Hazel Pascale; Parkinson Gary N; Neidle Stephen
Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex.
Journal of the American Chemical Society 2006;128(16):5480-7.
2006: Le Sann Christine; Baron Anne; Mann John; van den Berg Hendrik; Gunaratnam Mekala; Neidle Stephen
New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity.
Organic & biomolecular chemistry 2006;4(7):1305-12.
2006: Franceschin Marco; Rossetti Luigi; D'Ambrosio Anna; Schirripa Stefano; Bianco Armandodoriano; Ortaggi Giancarlo; Savino Maria; Schultes Christoph; Neidle Stephen
Natural and synthetic G-quadruplex interactive berberine derivatives.
Bioorganic & medicinal chemistry letters 2006;16(6):1707-11.
2006: Ladame Sylvain; Schouten James A; Roldan Jose; Redman James E; Neidle Stephen; Balasubramanian Shankar
Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein.
Biochemistry 2006;45(5):1393-9.
2006: Moore Michael J B; Schultes Christoph M; Cuesta Javier; Cuenca Francisco; Gunaratnam Mekala; Tanious Farial A; Wilson W David; Neidle Stephen
Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.
Journal of medicinal chemistry 2006;49(2):582-99.
2006: Campbell Nancy H; Evans David A; Lee Michael P H; Parkinson Gary N; Neidle Stephen
Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure.
Bioorganic & medicinal chemistry letters 2006;16(1):15-9.
2006: Burge Sarah; Parkinson Gary N; Hazel Pascale; Todd Alan K; Neidle Stephen
Quadruplex DNA: sequence, topology and structure.
Nucleic acids research 2006;34(19):5402-15.
2006: Hazel Pascale; Parkinson Gary N; Neidle Stephen
Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures.
Nucleic acids research 2006;34(7):2117-27.
2005: Miao Yi; Lee Michael P H; Parkinson Gary N; Batista-Parra Adalgisa; Ismail Mohamed A; Neidle Stephen; Boykin David W; Wilson W David
Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove.
Biochemistry 2005;44(45):14701-8.
2005: Rankin Sarah; Reszka Anthony P; Huppert Julian; Zloh Mire; Parkinson Gary N; Todd Alan K; Ladame Sylvain; Balasubramanian Shankar; Neidle Stephen
Putative DNA quadruplex formation within the human c-kit oncogene.
Journal of the American Chemical Society 2005;127(30):10584-9.
2005: Neidle Stephen; Thurston David E
Chemical approaches to the discovery and development of cancer therapies.
Nature reviews. Cancer 2005;5(4):285-96.
2005: Burger Angelika M; Dai Fangping; Schultes Christoph M; Reszka Anthony P; Moore Michael J; Double John A; Neidle Stephen
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.
Cancer research 2005;65(4):1489-96.
2005: Casely-Hayford Maxwell A; Pors Klaus; Patterson Laurence H; Gerner Clive; Neidle Stephen; Searcey Mark
Truncated azinomycin analogues intercalate into DNA.
Bioorganic & medicinal chemistry letters 2005;15(3):653-6.
2005: Todd Alan K; Johnston Matthew; Neidle Stephen
Highly prevalent putative quadruplex sequence motifs in human DNA.
Nucleic acids research 2005;33(9):2901-7.
2004: Hazel Pascale; Huppert Julian; Balasubramanian Shankar; Neidle Stephen
Loop-length-dependent folding of G-quadruplexes.
Journal of the American Chemical Society 2004;126(50):16405-15.
2004: Harrison R John; Reszka Anthony P; Haider Shozeb M; Romagnoli Barbara; Morrell James; Read Martin A; Gowan Sharon M; Incles Christopher M; Kelland Lloyd R; Neidle Stephen
Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.
Bioorganic & medicinal chemistry letters 2004;14(23):5845-9.
2004: Mallena Sirish; Lee Michael P H; Bailly Christian; Neidle Stephen; Kumar Arvind; Boykin David W; Wilson W David
Thiophene-based diamidine forms a "super" at binding minor groove agent.
Journal of the American Chemical Society 2004;126(42):13659-69.
2004: Incles Christopher M; Schultes Christoph M; Kempski Helena; Koehler Heike; Kelland Lloyd R; Neidle Stephen
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells.
Molecular cancer therapeutics 2004;3(10):1201-6.
2004: Ladame Sylvain; Schouten James A; Stuart John; Roldan Jose; Neidle Stephen; Balasubramanian Shankar
Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform.
Organic & biomolecular chemistry 2004;2(20):2925-31.
2004: Neidle Stephen
Stephen Neidle on cancer therapy and G-quadruplex inhibitors. Interview by Joanna De Souza.
Drug discovery today 2004;9(18):778-81.
2004: Schultes Christoph M; Guyen Bérangère; Cuesta Javier; Neidle Stephen
Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(16):4347-51.
2004: Guyen Berangere; Schultes Christoph M; Hazel Pascale; Mann John; Neidle Stephen
Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase.
Organic & biomolecular chemistry 2004;2(7):981-8.
2004: Nguyen Binh; Hamelberg Donald; Bailly Christian; Colson Pierre; Stanek Jaroslav; Brun Reto; Neidle Stephen; Wilson W David
Characterization of a novel DNA minor-groove complex.
Biophysical journal 2004;86(2):1028-41.
2003: Keppler Melanie D; James Peter L; Neidle Stephen; Brown Tom; Fox Keith R
DNA sequence specificity of triplex-binding ligands.
European journal of biochemistry / FEBS 2003;270(24):4982-92.
2003: Incles Christopher M; Schultes Christoph M; Kelland Lloyd R; Neidle Stephen
Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor.
Molecular pharmacology 2003;64(5):1101-8.
2003: Harrison R John; Cuesta Javier; Chessari Gianni; Read Martin A; Basra Sanji K; Reszka Anthony P; Morrell James; Gowan Sharon M; Incles Christopher M; Tanious Farial A; Wilson W David; Kelland Lloyd R; Neidle Stephen
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.
Journal of medicinal chemistry 2003;46(21):4463-76.
2003: Johansson Eric; Parkinson Gary N; Denny William A; Neidle Stephen
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form.
Journal of medicinal chemistry 2003;46(19):4009-20.
2003: Incles Christopher M; Schultes Christoph M; Neidle Stephen
Telomerase inhibitors in cancer therapy: current status and future directions.
Current opinion in investigational drugs (London, England : 2000) 2003;4(6):675-85.
2003: Neidle Stephen; Parkinson Gary N
The structure of telomeric DNA.
Current opinion in structural biology 2003;13(3):275-83.
2003: Joubert Alexandra; Sun Xiao-Wen; Johansson Eric; Bailly Christian; Mann John; Neidle Stephen
Sequence-selective targeting of long stretches of the DNA minor groove by a novel dimeric bis-benzimidazole.
Biochemistry 2003;42(20):5984-92.
2003: Clark George R; Pytel Patrycja D; Squire Christopher J; Neidle Stephen
Structure of the first parallel DNA quadruplex-drug complex.
Journal of the American Chemical Society 2003;125(14):4066-7.
2003: Bailly Christian; Chessari Gianni; Carrasco Carolina; Joubert Alexandra; Mann John; Wilson W David; Neidle Stephen
Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition.
Nucleic acids research 2003;31(5):1514-24.
2003: Cuesta Javier; Read Martin A; Neidle Stephen
The design of G-quadruplex ligands as telomerase inhibitors.
Mini reviews in medicinal chemistry 2003;3(1):11-21.
2003: Haider Shozeb M; Parkinson Gary N; Neidle Stephen
Structure of a G-quadruplex-ligand complex.
Journal of molecular biology 2003;326(1):117-25.
2002: Nguyen Binh; Lee Michael P H; Hamelberg Donald; Joubert Alexandra; Bailly Christian; Brun Reto; Neidle Stephen; Wilson W David
Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove.
Journal of the American Chemical Society 2002;124(46):13680-1.
2002: Ladame Sylvain; Harrison R John; Neidle Stephen; Balasubramanian Shankar
Solid-phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates.
Organic letters 2002;4(15):2509-12.
2002: Haider Shozeb; Parkinson Gary N; Neidle Stephen
Crystal structure of the potassium form of an Oxytricha nova G-quadruplex.
Journal of molecular biology 2002;320(2):189-200.
2002: Parkinson Gary N; Lee Michael P H; Neidle Stephen
Crystal structure of parallel quadruplexes from human telomeric DNA.
Nature 2002;417(6891):876-80.
2002: Neidle Stephen; Parkinson Gary
Telomere maintenance as a target for anticancer drug discovery.
Nature reviews. Drug discovery 2002;1(5):383-93.
2002: Gowan Sharon M; Harrison John R; Patterson Lisa; Valenti Melanie; Read Martin A; Neidle Stephen; Kelland Lloyd R
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity.
Molecular pharmacology 2002;61(5):1154-62.
2001: Li J L; Harrison R J; Reszka A P; Brosh R M; Bohr V A; Neidle S; Hickson I D
Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands.
Biochemistry 2001;40(50):15194-202.
2001: Keppler M D; Neidle S; Fox K R
Stabilisation of TG- and AG-containing antiparallel DNA triplexes by triplex-binding ligands.
Nucleic acids research 2001;29(9):1935-42.
2001: Read M; Harrison R J; Romagnoli B; Tanious F A; Gowan S H; Reszka A P; Wilson W D; Kelland L R; Neidle S
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):4844-9.
2001: Mann J; Baron A; Opoku-Boahen Y; Johansson E; Parkinson G; Kelland L R; Neidle S
A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity.
Journal of medicinal chemistry 2001;44(2):138-44.
2000: Simpson I J; Lee M; Kumar A; Boykin D W; Neidle S
DNA minor groove interactions and the biological activity of 2,5-bis.
Bioorganic & medicinal chemistry letters 2000;10(23):2593-7.
2000: Parkinson G N; Skelly J V; Neidle S
Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme.
Journal of medicinal chemistry 2000;43(20):3624-31.
2000: Caprio V; Guyen B; Opoku-Boahen Y; Mann J; Gowan S M; Kelland L M; Read M A; Neidle S
A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline.
Bioorganic & medicinal chemistry letters 2000;10(18):2063-6.
2000: Mazur S; Tanious F A; Ding D; Kumar A; Boykin D W; Simpson I J; Neidle S; Wilson W D
A thermodynamic and structural analysis of DNA minor-groove complex formation.
Journal of molecular biology 2000;300(2):321-37.
2000: Neidle S; Harrison R J; Reszka A P; Read M A
Structure-activity relationships among guanine-quadruplex telomerase inhibitors.
Pharmacology & therapeutics 2000;85(3):133-9.
2000: Neidle S; Read M A
G-quadruplexes as therapeutic targets.
Biopolymers 2000;56(3):195-208.
1999: Read M A; Wood A A; Harrison J R; Gowan S M; Kelland L R; Dosanjh H S; Neidle S
Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships.
Journal of medicinal chemistry 1999;42(22):4538-46.
1999: Skelly J V; Sanderson M R; Suter D A; Baumann U; Read M A; Gregory D S; Bennett M; Hobbs S M; Neidle S
Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954).
Journal of medicinal chemistry 1999;42(21):4325-30.
1999: Harrison R J; Gowan S M; Kelland L R; Neidle S
Human telomerase inhibition by substituted acridine derivatives.
Bioorganic & medicinal chemistry letters 1999;9(17):2463-8.
1999: Perry P J; Gowan S M; Read M A; Kelland L R; Neidle S
Design, synthesis and evaluation of human telomerase inhibitors based upon a tetracyclic structural motif.
Anti-cancer drug design 1999;14(4):373-82.
1999: Keppler M D; Read M A; Perry P J; Trent J O; Jenkins T C; Reszka A P; Neidle S; Fox K R
Stabilization of DNA triple helices by a series of mono- and disubstituted amidoanthraquinones.
European journal of biochemistry / FEBS 1999;263(3):817-25.
1999: Perry P J; Read M A; Davies R T; Gowan S M; Reszka A P; Wood A A; Kelland L R; Neidle S
2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase.
Journal of medicinal chemistry 1999;42(14):2679-84.
1999: Aymami J; Nunn C M; Neidle S
DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand.
Nucleic acids research 1999;27(13):2691-8.
1998: Perry P J; Reszka A P; Wood A A; Read M A; Gowan S M; Dosanjh H S; Trent J O; Jenkins T C; Kelland L R; Neidle S
Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.
Journal of medicinal chemistry 1998;41(24):4873-84.
1998: Perry P J; Gowan S M; Reszka A P; Polucci P; Jenkins T C; Kelland L R; Neidle S
1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.
Journal of medicinal chemistry 1998;41(17):3253-60.
1998: Nunn C M; Neidle S
Structure of the DNA decamer d(GGCAATTGCG) contains both major- and minor-groove binding G.(G.C) base triplets.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 4):577-83.
1998: Guerri A; Simpson I J; Neidle S
Visualisation of extensive water ribbons and networks in a DNA minor-groove drug complex.
Nucleic acids research 1998;26(12):2873-8.
1998: Neidle S; Nunn C M
Crystal structures of nucleic acids and their drug complexes.
Natural product reports 1998;15(1):1-15.
1998: Adzhubei I A; Adzhubei A A; Neidle S
An Integrated Sequence-Structure Database incorporating matching mRNA sequence, amino acid sequence and protein three-dimensional structure data.
Nucleic acids research 1998;26(1):327-31.
1997: Cassidy S A; Slickers P; Trent J O; Capaldi D C; Roselt P D; Reese C B; Neidle S; Fox K R
Recognition of GC base pairs by triplex forming oligonucleotides containing nucleosides derived from 2-aminopyridine.
Nucleic acids research 1997;25(24):4891-8.
1997: Nunn C M; Trent J O; Neidle S
A model for the [C+-GxC]n triple helix derived from observation of the C+-GxC base triplet in a crystal structure.
FEBS letters 1997;416(1):86-9.
1997: Wood A A; Nunn C M; Trent J O; Neidle S
Sequence-dependent crossed helix packing in the crystal structure of a B-DNA decamer yields a detailed model for the Holliday junction.
Journal of molecular biology 1997;269(5):827-41.
1997: Nunn C M; Neidle S
Structure of the A-DNA octamer d(GGCATGCC).
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 3):269-73.
1997: Clark G R; Boykin D W; Czarny A; Neidle S
Structure of a bis-amidinium derivative of hoechst 33258 complexed to dodecanucleotide d(CGCGAATTCGCG)2: the role of hydrogen bonding in minor groove drug-DNA recognition.
Nucleic acids research 1997;25(8):1510-5.
1997: Nunn C M; Garman E; Neidle S
Crystal structure of the DNA decamer d(CGCAATTGCG) complexed with the minor groove binding drug netropsin.
Biochemistry 1997;36(16):4792-9.
1996: Clark G R; Squire C J; Gray E J; Leupin W; Neidle S
Designer DNA-binding drugs: the crystal structure of a meta-hydroxy analogue of Hoechst 33258 bound to d(CGCGAATTCGCG)2.
Nucleic acids research 1996;24(24):4882-9.
1996: Adzhubei A A; Adzhubei I A; Krasheninnikov I A; Neidle S
Non-random usage of 'degenerate' codons is related to protein three-dimensional structure.
FEBS letters 1996;399(1-2):78-82.
1996: Bates P J; Laughton C A; Jenkins T C; Capaldi D C; Roselt P D; Reese C B; Neidle S
Efficient triple helix formation by oligodeoxyribonucleotides containing alpha- or beta-2-amino-5-(2-deoxy-D-ribofuranosyl) pyridine residues.
Nucleic acids research 1996;24(21):4176-84.
1996: Trent J O; Clark G R; Kumar A; Wilson W D; Boykin D W; Hall J E; Tidwell R R; Blagburn B L; Neidle S
Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2.
Journal of medicinal chemistry 1996;39(23):4554-62.
1996: Clark G R; Gray E J; Neidle S; Li Y H; Leupin W
Isohelicity and phasing in drug--DNA sequence recognition: crystal structure of a tris(benzimidazole)--oligonucleotide complex.
Biochemistry 1996;35(43):13745-52.
1996: Laughton C A; Tanious F; Nunn C M; Boykin D W; Wilson W D; Neidle S
A crystallographic and spectroscopic study of the complex between d(CGCGAATTCGCG)2 and 2,5-bis(4-guanylphenyl)furan, an analogue of berenil. Structural origins of enhanced DNA-binding affinity.
Biochemistry 1996;35(18):5655-61.
1996: Nunn C M; Neidle S
The high resolution crystal structure of the DNA decamer d(AGGCATGCCT).
Journal of molecular biology 1996;256(2):340-51.
1995: Bates P J; Macaulay V M; McLean M J; Jenkins T C; Reszka A P; Laughton C A; Neidle S
Characteristics of triplex-directed photoadduct formation by psoralen-linked oligodeoxynucleotides.
Nucleic acids research 1995;23(21):4283-9.
1995: Spink N; Nunn C M; Vojtechovsky J; Berman H M; Neidle S
Crystal structure of a DNA decamer showing a novel pseudo four-way helix-helix junction.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10767-71.
1995: Macaulay V M; Bates P J; McLean M J; Rowlands M G; Jenkins T C; Ashworth A; Neidle S
Inhibition of aromatase expression by a psoralen-linked triplex-forming oligonucleotide targeted to a coding sequence.
FEBS letters 1995;372(2-3):222-8.
1995: Wood A A; Nunn C M; Czarny A; Boykin D W; Neidle S
Variability in DNA minor groove width recognised by ligand binding: the crystal structure of a bis-benzimidazole compound bound to the DNA duplex d(CGCGAATTCGCG)2.
Nucleic acids research 1995;23(18):3678-84.
1995: Bates P J; Dosanjh H S; Kumar S; Jenkins T C; Laughton C A; Neidle S
Detection and kinetic studies of triplex formation by oligodeoxynucleotides using real-time biomolecular interaction analysis (BIA).
Nucleic acids research 1995;23(18):3627-32.
1995: Fox K R; Polucci P; Jenkins T C; Neidle S
A molecular anchor for stabilizing triple-helical DNA.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7887-91.
1995: Adzhubei A A; Laughton C A; Neidle S
An approach to protein homology modelling based on an ensemble of NMR structures: application to the Sox-5 HMG-box protein.
Protein engineering 1995;8(7):615-25.
1995: Nunn C M; Neidle S
Sequence-dependent drug binding to the minor groove of DNA: crystal structure of the DNA dodecamer d(CGCAAATTTGCG)2 complexed with propamidine.
Journal of medicinal chemistry 1995;38(13):2317-25.
1995: Ford K G; Neidle S
Perturbations in DNA structure upon interaction with porphyrins revealed by chemical probes, DNA footprinting and molecular modelling.
Bioorganic & medicinal chemistry 1995;3(6):671-7.
1995: Neidle S; Snook C F; Murrer B A; Barnard C F
Bis(acetato)amminedichloro(cyclohexylamine)platinum(IV), an orally active anticancer drug.
Acta crystallographica. Section C, Crystal structure communications 1995;51 ( Pt 5)():822-4.
1995: Hardcastle I R; Rowlands M G; Houghton J; Parr I B; Potter G A; Jarman M; Edwards K J; Laughton C A; Trent J O; Neidle S
Rationally designed analogues of tamoxifen with improved calmodulin antagonism.
Journal of medicinal chemistry 1995;38(2):241-8.
1994: Nunn C M; Jenkins T C; Neidle S
Crystal structure of gamma-oxapentamidine complexed with d(CGCGAATTCGCG)2. The effects of drug structural change on DNA minor-groove recognition.
European journal of biochemistry / FEBS 1994;226(3):953-61.
1994: Jenkins T C; Hurley L H; Neidle S; Thurston D E
Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking.
Journal of medicinal chemistry 1994;37(26):4529-37.
1994: Neidle S; Goodwin G H
A homology-based molecular model of the proline-rich homeodomain protein Prh, from haematopoietic cells.
FEBS letters 1994;345(2-3):93-8.
1994: Spink N; Brown D G; Skelly J V; Neidle S
Sequence-dependent effects in drug-DNA interaction: the crystal structure of Hoechst 33258 bound to the d(CGCAAATTTGCG)2 duplex.
Nucleic acids research 1994;22(9):1607-12.
1993: Nunn C M; Jenkins T C; Neidle S
Crystal structure of d(CGCGAATTCGCG) complexed with propamidine, a short-chain homologue of the drug pentamidine.
Biochemistry 1993;32(50):13838-43.
1993: Greenidge P A; Jenkins T C; Neidle S
DNA minor groove recognition properties of pentamidine and its analogs: a molecular modeling study.
Molecular pharmacology 1993;43(6):982-8.
1993: Jenkins T C; Lane A N; Neidle S; Brown D G
NMR and molecular modeling studies of the interaction of berenil and pentamidine with d(CGCAAATTTGCG)2.
European journal of biochemistry / FEBS 1993;213(3):1175-84.
1993: Laughton C A; Zvelebil M J; Neidle S
A detailed molecular model for human aromatase.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):399-407.
1993: Skelly J V; Edwards K J; Jenkins T C; Neidle S
Crystal structure of an oligonucleotide duplex containing G.G base pairs: influence of mispairing on DNA backbone conformation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(3):804-8.
1992: Laughton C A; Neidle S
Prediction of the structure of the Y+.R-.R(+)-type DNA triple helix by molecular modelling.
Nucleic acids research 1992;20(24):6535-41.
1992: Tanious F A; Jenkins T C; Neidle S; Wilson W D
Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs.
Biochemistry 1992;31(46):11632-40.
1992: Edwards K J; Jenkins T C; Neidle S
Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties.
Biochemistry 1992;31(31):7104-9.
1992: Edwards K J; Brown D G; Spink N; Skelly J V; Neidle S
Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2. An examination of propeller twist and minor-groove water structure at 2.2 A resolution.
Journal of molecular biology 1992;226(4):1161-73.
1992: Edwards K J; Laughton C A; Neidle S
A note on the conformational flexibility of the antiestrogenic drug tamoxifen: preferred conformations in the free state and bound to the protein calmodulin.
Acta crystallographica. Section B, Structural science 1992;48 ( Pt 4)():511-4.
1992: Herzyk P; Neidle S; Goodfellow J M
Conformation and dynamics of drug-DNA intercalation.
Journal of biomolecular structure & dynamics 1992;10(1):97-139.
1992: Brown D G; Sanderson M R; Garman E; Neidle S
Crystal structure of a berenil-d(CGCAAATTTGCG) complex. An example of drug-DNA recognition based on sequence-dependent structural features.
Journal of molecular biology 1992;226(2):481-90.
1992: Edwards K J; Laughton C A; Neidle S
A molecular modeling study of the interactions between the antiestrogen drug tamoxifen and several derivatives, and the calcium-binding protein calmodulin.
Journal of medicinal chemistry 1992;35(15):2753-61.
1992: Agbandje M; Jenkins T C; McKenna R; Reszka A P; Neidle S
Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives.
Journal of medicinal chemistry 1992;35(8):1418-29.
1992: Neidle S; Wilman D E
X-ray studies on anti-tumour triazenes. Structures of 1-(4-carbamoylphenyl)-3,3-dimethyltriazene 1-oxide and 3,3-dimethyl-1-(4-nitrophenyl)triazene.
Acta crystallographica. Section B, Structural science 1992;48 ( Pt 2)():213-7.
1992: Neidle S
Minor-groove width and accessibility in B-DNA drug and protein complexes.
FEBS letters 1992;298(1):97-9.
1991: McKenna R; Neidle S; Wilson W D
Structures of 1-(3,3-dimethylamino)propyl naphtho[2,1-b]thiophene-4- carboxylate and N-(3,3-dimethylamino)propyl-8-methoxynaphtho[2,1- b]thiophene-4-carboxamide, intercalators into double-helical DNA.
Acta crystallographica. Section C, Crystal structure communications 1991;47 ( Pt 11)():2511-3.
1991: Walton A R; Jenkins T C; Neidle S
Studies on 1,3-diaryltriazene analogues of berenil: molecules with potential GC base-pair selectivity.
Acta crystallographica. Section B, Structural science 1991;47 ( Pt 5)():771-5.
1991: Herzyk P; Goodfellow J M; Neidle S
Molecular dynamics simulations of dinucleoside and dinucleoside-drug crystal hydrates.
Journal of biomolecular structure & dynamics 1991;9(2):363-86.
1990: Laughton C A; Neidle S
Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity.
Journal of medicinal chemistry 1990;33(11):3055-60.
1990: Orozco M; Laughton C A; Herzyk P; Neidle S
Molecular-mechanics modelling of drug-DNA structures; the effects of differing dielectric treatment on helix parameters and comparison with a fully solvated structural model.
Journal of biomolecular structure & dynamics 1990;8(2):359-73.
1990: Webster G D; Sanderson M R; Skelly J V; Neidle S; Swann P F; Li B F; Tickle I J
Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6693-7.
1990: Laughton C A; McKenna R; Neidle S; Jarman M; McCague R; Rowlands M G
Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.
Journal of medicinal chemistry 1990;33(9):2673-9.
1990: Laughton C A; Neidle S; Zvelebil M J; Sternberg M J
A molecular model for the enzyme cytochrome P450(17 alpha), a major target for the chemotherapy of prostatic cancer.
Biochemical and biophysical research communications 1990;171(3):1160-7.
1990: Clark G R; Brown D G; Sanderson M R; Chwalinski T; Neidle S; Veal J M; Jones R L; Wilson W D; Zon G; Garman E
Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study.
Nucleic acids research 1990;18(18):5521-8.
1990: Laughton C A; Jenkins T C; Fox K R; Neidle S
Interaction of berenil with the tyrT DNA sequence studied by footprinting and molecular modelling. Implications for the design of sequence-specific DNA recognition agents.
Nucleic acids research 1990;18(15):4479-88.
1990: Brown D G; Sanderson M R; Skelly J V; Jenkins T C; Brown T; Garman E; Stuart D I; Neidle S
Crystal structure of a berenil-dodecanucleotide complex: the role of water in sequence-specific ligand binding.
The EMBO journal 1990;9(4):1329-34.
1990: Skelly J V; Suter D A; Kuroda R; Neidle S; Hancock J F; Drake A
Conformational effects of nucleotide exchange in ras p21 proteins as studied by fluorescence spectroscopy.
FEBS letters 1990;262(1):127-30.
1989: Neidle S; Urpi L; Serafinowski P; Whitby D
The anti-conformation of 2',3'-dideoxy nucleosides may be essential for anti-HIV activity: evidence from the crystal structure of 2',3'-dideoxy formycin A.
Biochemical and biophysical research communications 1989;161(2):910-6.
1989: McKenna R; Beveridge A J; Jenkins T C; Neidle S; Denny W A
Molecular modelling of DNA-antitumour drug intercalation interactions: correlation of structural and energetic features with biological properties for a series of phenylquinoline-8-carboxamide compounds.
Molecular pharmacology 1989;35(5):720-8.
1989: Skelly J V; Suter D A; Knox R J; Garman E; Stuart D I; Sanderson M R; Roberts J J; Neidle S
Preliminary crystallographic data for NAD(P)H quinone reductase isolated from the Walker 256 rat carcinoma cell line.
Journal of molecular biology 1989;205(3):623-4.
1988: Abraham Z H; Agbandje M; Neidle S; Acheson R M
Experimental DNA-binding and computer modelling studies on an analogue of the anti-tumor drug amsacrine.
Journal of biomolecular structure & dynamics 1988;6(3):471-88.
1988: Neidle S; Pearl L H; Herzyk P; Berman H M
A molecular model for proflavine-DNA intercalation.
Nucleic acids research 1988;16(18):8999-9016.
1988: Collier D A; Neidle S
Synthesis, molecular modeling, DNA binding, and antitumor properties of some substituted amidoanthraquinones.
Journal of medicinal chemistry 1988;31(4):847-57.
1987: Wilson W D; Chandrasekaran S; Kusuma S; Boykin D W; Neidle S
The influence of intercalator structure on DNA binding strength: the importance of side chain orientation.
Journal of biomolecular structure & dynamics 1987;5(2):327-44.
1987: Hudson B D; Kuroda R; Denny W A; Neidle S
Crystallographic and molecular mechanics calculations on the anti-tumor drugs N-[(2-dimethylamino)ethyl]-and N-[(2-dimethyl-amino)butyl]-9-aminoacridine-4-carboxamides and their dications: implications for models of DNA-binding.
Journal of biomolecular structure & dynamics 1987;5(1):145-58.
1985: Aggarwal A; Neidle S
Variability in the geometry of RNA double helices generated from dinucleoside building-blocks.
Journal of biomolecular structure & dynamics 1985;2(6):1235-43.

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