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Andre Nel

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Oxidative Stress

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Publications

TOP 3
Xia Tian; Kovochich Michael; Liong Monty; Meng Huan; Kabehie Sanaz; George Saji; Zink Jeffrey I; Nel Andre E
Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs.
Godwin Hilary A; Chopra Kabir; Bradley Kenneth A; Cohen Yoram; Harthorn Barbara Herr; Hoek Eric M V; Holden Patricia; Keller Arturo A; Lenihan Hunter S; Nisbet Roger M; Nel Andre E
The University of California Center for the Environmental Implications of Nanotechnology.
Kovochich Michael; Espinasse Benjamin; Auffan Melanie; Hotze Ernest M; Wessel Lauren; Xia Tian; Nel Andre E; Wiesner Mark R
Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition.

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All Publications

2009: Xia Tian; Kovochich Michael; Liong Monty; Meng Huan; Kabehie Sanaz; George Saji; Zink Jeffrey I; Nel Andre E
Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs.
ACS nano 2009;3(10):3273-86.
2009: Godwin Hilary A; Chopra Kabir; Bradley Kenneth A; Cohen Yoram; Harthorn Barbara Herr; Hoek Eric M V; Holden Patricia; Keller Arturo A; Lenihan Hunter S; Nisbet Roger M; Nel Andre E
The University of California Center for the Environmental Implications of Nanotechnology.
Environmental science & technology 2009;43(17):6453-7.
2009: Kovochich Michael; Espinasse Benjamin; Auffan Melanie; Hotze Ernest M; Wessel Lauren; Xia Tian; Nel Andre E; Wiesner Mark R
Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition.
Environmental science & technology 2009;43(16):6378-84.
2009: Li Ning; Wang Meiying; Bramble Lori A; Schmitz Debra A; Schauer James J; Sioutas Constantinos; Harkema Jack R; Nel Andre E
The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential.
Environmental health perspectives 2009;117(7):1116-23.
2009: Nel Andre E; Mädler Lutz; Velegol Darrell; Xia Tian; Hoek Eric M V; Somasundaran Ponisseril; Klaessig Fred; Castranova Vince; Thompson Mike
Understanding biophysicochemical interactions at the nano-bio interface.
Nature materials 2009;8(7):543-57.
2009: Zhang Lifeng; Wang Meiying; Kang Xuedong; Boontheung Pinmanee; Li Ning; Nel Andre E; Loo Joseph A
Oxidative stress and asthma: proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid.
Journal of proteome research 2009;8(4):1631-8.
2009: Xia Tian; Li Ning; Nel Andre E
Potential health impact of nanoparticles.
Annual review of public health 2009;30():137-50.
2009: Araujo Jesus A; Nel Andre E
Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress.
Particle and fibre toxicology 2009;6():24.
2008: Xia Tian; Kovochich Michael; Liong Monty; Mädler Lutz; Gilbert Benjamin; Shi Haibin; Yeh Joanne I; Zink Jeffrey I; Nel Andre E
Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.
ACS nano 2008;2(10):2121-34.
2008: Schröder Nicolas W J; Crother Timothy R; Naiki Yoshikazu; Chen Shuang; Wong Michelle H; Yilmaz Atilla; Slepenkin Anatoly; Schulte Danica; Alsabeh Randa; Doherty Terence M; Peterson Ellena; Nel Andre E; Arditi Moshe
Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization.
The Journal of allergy and clinical immunology 2008;122(3):595-602.e5.
2008: Liong Monty; Lu Jie; Kovochich Michael; Xia Tian; Ruehm Stefan G; Nel Andre E; Tamanoi Fuyuhiko; Zink Jeffrey I
Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.
ACS nano 2008;2(5):889-96.
2008: Kleinman M T; Araujo J A; Nel A; Sioutas C; Campbell A; Cong P Q; Li H; Bondy S C
Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways.
Toxicology letters 2008;178(2):127-30.
2008: Kim Hyon-Jeen; Barajas Berenice; Wang Meiying; Nel Andre E
Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells.
The Journal of allergy and clinical immunology 2008;121(5):1255-1261.e7.
2008: Li Ning; Xia Tian; Nel Andre E
The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles.
Free radical biology & medicine 2008;44(9):1689-99.
2008: Chatila Talal A; Li Ning; Garcia-Lloret Maria; Kim Hyon-Jeen; Nel Andre E
T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets.
The Journal of allergy and clinical immunology 2008;121(4):812-23; quiz 824-5.
2008: Araujo Jesus A; Barajas Berenice; Kleinman Michael; Wang Xuping; Bennett Brian J; Gong Ke Wei; Navab Mohamad; Harkema Jack; Sioutas Constantinos; Lusis Aldons J; Nel Andre E
Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress.
Circulation research 2008;102(5):589-96.
2008: Riedl Marc A; Nel Andre E
Importance of oxidative stress in the pathogenesis and treatment of asthma.
Current opinion in allergy and clinical immunology 2008;8(1):49-56.
2008: Xia Tian; Kovochich Michael; Liong Monty; Zink Jeffrey I; Nel Andre E
Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways.
ACS nano 2008;2(1):85-96.
2008: Ayres Jon G; Borm Paul; Cassee Flemming R; Castranova Vincent; Donaldson Ken; Ghio Andy; Harrison Roy M; Hider Robert; Kelly Frank; Kooter Ingeborg M; Marano Francelyne; Maynard Robert L; Mudway Ian; Nel Andre; Sioutas Constantinos; Smith Steve; Baeza-Squiban Armelle; Cho Art; Duggan Sean; Froines John
Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential--a workshop report and consensus statement.
Inhalation toxicology 2008;20(1):75-99.
2007: Jung EunMi Juliana; Avliyakulov Nuraly K; Boontheung Pinmanee; Loo Joseph A; Nel Andre E
Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis.
Proteomics 2007;7(21):3906-18.
2007: Shi Haibin; Xia Tian; Nel Andre E; Yeh Joanne I
Part II: coordinated biosensors--development of enhanced nanobiosensors for biological and medical applications.
Nanomedicine (London, England) 2007;2(5):599-614.
2007: Kim Hyon-Jeen; Barajas Berenice; Chan Ray Chun-Fai; Nel Andre E
Glutathione depletion inhibits dendritic cell maturation and delayed-type hypersensitivity: implications for systemic disease and immunosenescence.
The Journal of allergy and clinical immunology 2007;119(5):1225-33.
2007: Gong Ke Wei; Zhao Wei; Li Ning; Barajas Berenice; Kleinman Michael; Sioutas Constantinos; Horvath Steve; Lusis Aldons J; Nel Andre; Araujo Jesus A
Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells.
Genome biology 2007;8(7):R149.
2007: Xia Tian; Kovochich Michael; Nel Andre E
Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease.
Frontiers in bioscience : a journal and virtual library 2007;12():1238-46.
2006: Xia Tian; Kovochich Michael; Brant Jonathan; Hotze Matt; Sempf Joan; Oberley Terry; Sioutas Constantinos; Yeh Joanne I; Wiesner Mark R; Nel Andre E
Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm.
Nano letters 2006;6(8):1794-807.
2006: Chan Ray Chun-Fai; Wang Meiying; Li Ning; Yanagawa Yoshiki; Onoé Kazunori; Lee James J; Nel Andre E
Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation.
The Journal of allergy and clinical immunology 2006;118(2):455-65.
2006: Phalen Robert F; Oldham Michael J; Nel Andre E
Tracheobronchial particle dose considerations for in vitro toxicology studies.
Toxicological sciences : an official journal of the Society of Toxicology 2006;92(1):126-32.
2006: Gilmour M Ian; Jaakkola Maritta S; London Stephanie J; Nel Andre E; Rogers Christine A
How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma.
Environmental health perspectives 2006;114(4):627-33.
2006: Nel Andre; Xia Tian; Mädler Lutz; Li Ning
Toxic potential of materials at the nanolevel.
Science (New York, N.Y.) 2006;311(5761):622-7.
2006: Li Ning; Nel Andre E
Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma.
Antioxidants & redox signaling 2006;8(1-2):88-98.
2006: Xia Tian; Kovochich Michael; Nel Andre
The role of reactive oxygen species and oxidative stress in mediating particulate matter injury.
Clinics in occupational and environmental medicine 2006;5(4):817-36.
2005: Kim Hyon-Jeen; Nel Andre E
The role of phase II antioxidant enzymes in protecting memory T cells from spontaneous apoptosis in young and old mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):2948-59.
2005: Wang Meiying; Xiao Gary Guishan; Li Ning; Xie Yongming; Loo Joseph A; Nel Andre E
Use of a fluorescent phosphoprotein dye to characterize oxidative stress-induced signaling pathway components in macrophage and epithelial cultures exposed to diesel exhaust particle chemicals.
Electrophoresis 2005;26(11):2092-108.
2005: Nel André
Atmosphere. Air pollution-related illness: effects of particles.
Science (New York, N.Y.) 2005;308(5723):804-6.
2005: Xiao Gary Guishan; Nel Andre E; Loo Joseph A
Nitrotyrosine-modified proteins and oxidative stress induced by diesel exhaust particles.
Electrophoresis 2005;26(1):280-92.
2004: Bernstein Jonathan A; Alexis Neil; Barnes Charles; Bernstein I Leonard; Bernstein Jonathan A; Nel Andre; Peden David; Diaz-Sanchez David; Tarlo Susan M; Williams P Brock
Health effects of air pollution.
The Journal of allergy and clinical immunology 2004;114(5):1116-23.
2004: Xia Tian; Korge Paavo; Weiss James N; Li Ning; Venkatesen M Indira; Sioutas Constantinos; Nel Andre
Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity.
Environmental health perspectives 2004;112(14):1347-58.
2004: Li Ning; Alam Jawed; Venkatesan M Indira; Eiguren-Fernandez Arantza; Schmitz Debra; Di Stefano Emma; Slaughter Ndaisha; Killeen Erin; Wang Xiaorong; Huang Aaron; Wang Meiying; Miguel Antonio H; Cho Arthur; Sioutas Constantinos; Nel Andre E
Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3467-81.
2004: Tu Xiaolin; Huang Aaron; Bae David; Slaughter Ndaisha; Whitelegge Julian; Crother Timothy; Bickel Perry E; Nel Andre
Proteome analysis of lipid rafts in Jurkat cells characterizes a raft subset that is involved in NF-kappaB activation.
Journal of proteome research 2004;3(3):445-54.
2003: Li Ning; Hao Minqi; Phalen Robert F; Hinds William C; Nel Andre E
Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects.
Clinical immunology (Orlando, Fla.) 2003;109(3):250-65.
2003: Xiao Gary Guishan; Wang Meiying; Li Ning; Loo Joseph A; Nel Andre E
Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line.
The Journal of biological chemistry 2003;278(50):50781-90.
2003: Hao Minqi; Comier Stephania; Wang Meiying; Lee James J; Nel Andre
Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models.
The Journal of allergy and clinical immunology 2003;112(5):905-14.
2003: Slaughter Ndaisha; Laux Isett; Tu Xiaolin; Whitelegge Julian; Zhu Xiaoming; Effros Rita; Bickel Perry; Nel Andre
The flotillins are integral membrane proteins in lipid rafts that contain TCR-associated signaling components: implications for T-cell activation.
Clinical immunology (Orlando, Fla.) 2003;108(2):138-51.
2003: Lippmann Morton; Frampton Mark; Schwartz Joel; Dockery Douglas; Schlesinger Richard; Koutrakis Petros; Froines John; Nel Andre; Finkelstein Jack; Godleski John; Kaufman Joel; Koenig Jane; Larson Tim; Luchtel Dan; Liu L-J Sally; Oberdorster Gunter; Peters Annette; Sarnat Jeremy; Sioutas Constantinos; Suh Helen; Sullivan Jeff; Utell Mark; Wichmann Erich; Zelikoff Judith
The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans.
Environmental health perspectives 2003;111(8):1074-92.
2003: Li Ning; Sioutas Constantinos; Cho Arthur; Schmitz Debra; Misra Chandan; Sempf Joan; Wang Meiying; Oberley Terry; Froines John; Nel Andre
Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage.
Environmental health perspectives 2003;111(4):455-60.
2002: Li Ning; Wang Meiying; Oberley Terry D; Sempf Joan M; Nel Andre E
Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4531-41.
2002: Zhang Ke; Zhang Ling; Zhu Daocheng; Bae David; Nel Andre; Saxon Andrew
CD40-mediated p38 mitogen-activated protein kinase activation is required for immunoglobulin class switch recombination to IgE.
The Journal of allergy and clinical immunology 2002;110(3):421-8.
2002: Nel Andre E; Slaughter Ndaisha
T-cell activation through the antigen receptor. Part 2: role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy.
The Journal of allergy and clinical immunology 2002;109(6):901-15.
2002: Li Ning; Kim Seongheon; Wang Meiying; Froines John; Sioutas Constantinos; Nel Andre
Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter.
Inhalation toxicology 2002;14(5):459-86.
2002: Nel Andre E
T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse.
The Journal of allergy and clinical immunology 2002;109(5):758-70.
2002: Whitekus Michael J; Li Ning; Zhang Min; Wang Meiying; Horwitz Marcus A; Nelson Sally K; Horwitz Lawrence D; Brechun Nicholas; Diaz-Sanchez David; Nel Andre E
Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(5):2560-7.
2002: Yuan Jingzhen; Bae David; Cantrell Doreen; Nel Andre E; Rozengurt Enrique
Protein kinase D is a downstream target of protein kinase Ctheta.
Biochemical and biophysical research communications 2002;291(3):444-52.
2001: Laux I; Nel A
Evidence that oxidative stress-induced apoptosis by menadione involves Fas-dependent and Fas-independent pathways.
Clinical immunology (Orlando, Fla.) 2001;101(3):335-44.
2001: Nel A E; Diaz-Sanchez D; Li N
The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress.
Current opinion in pulmonary medicine 2001;7(1):20-6.
2000: Khoshnan A; Bae D; Tindell C A; Nel A E
The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6933-40.
2000: Diaz-Sanchez D; Jyrala M; Ng D; Nel A; Saxon A
In vivo nasal challenge with diesel exhaust particles enhances expression of the CC chemokines rantes, MIP-1alpha, and MCP-3 in humans.
Clinical immunology (Orlando, Fla.) 2000;97(2):140-5.
2000: Li N; Venkatesan M I; Miguel A; Kaplan R; Gujuluva C; Alam J; Nel A
Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3393-401.
2000: Laux I; Khoshnan A; Tindell C; Bae D; Zhu X; June C H; Effros R B; Nel A
Response differences between human CD4(+) and CD8(+) T-cells during CD28 costimulation: implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging.
Clinical immunology (Orlando, Fla.) 2000;96(3):187-97.
2000: Hiura T S; Li N; Kaplan R; Horwitz M; Seagrave J C; Nel A E
The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2703-11.
2000: Khoshnan A; Tindell C; Laux I; Bae D; Bennett B; Nel A E
The NF-kappa B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1743-54.
1999: Casillas A M; Hiura T; Li N; Nel A E
Enhancement of allergic inflammation by diesel exhaust particles: permissive role of reactive oxygen species.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 1999;83(6 Pt 2):624-9.
1999: Hiura T S; Kaszubowski M P; Li N; Nel A E
Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5582-91.
1999: Khoshnan A; Kempiak S J; Bennett B L; Bae D; Xu W; Manning A M; June C H; Nel A E
Primary human CD4+ T cells contain heterogeneous I kappa B kinase complexes: role in activation of the IL-2 promoter.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5444-52.
1999: Kempiak S J; Hiura T S; Nel A E
The Jun kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter: proof of cross-talk with the I kappa B kinase cascade.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3176-87.
1999: Hiura T S; Kempiak S J; Nel A E
Activation of the human RANTES gene promoter in a macrophage cell line by lipopolysaccharide is dependent on stress-activated protein kinases and the IkappaB kinase cascade: implications for exacerbation of allergic inflammation by environmental pollutants.
Clinical immunology (Orlando, Fla.) 1999;90(3):287-301.
1999: Abreu-Martin M T; Palladino A A; Faris M; Carramanzana N M; Nel A E; Targan S R
Fas activates the JNK pathway in human colonic epithelial cells: lack of a direct role in apoptosis.
The American journal of physiology 1999;276(3 Pt 1):G599-605.
1998: Nel A; Gujuluva C
Latex antigens: identification and use in clinical and experimental studies, including crossreactivity with food and pollen allergens.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 1998;81(5 Pt 1):388-96; quiz 397-8.
1998: Nel A E; Diaz-Sanchez D; Ng D; Hiura T; Saxon A
Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system.
The Journal of allergy and clinical immunology 1998;102(4 Pt 1):539-54.
1998: Faris M; Latinis K M; Kempiak S J; Koretzky G A; Nel A
Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter.
Molecular and cellular biology 1998;18(9):5414-24.
1998: Ng D; Kokot N; Hiura T; Faris M; Saxon A; Nel A
Macrophage activation by polycyclic aromatic hydrocarbons: evidence for the involvement of stress-activated protein kinases, activator protein-1, and antioxidant response elements.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):942-51.
1998: Faris M; Kokot N; Latinis K; Kasibhatla S; Green D R; Koretzky G A; Nel A
The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):134-44.
1998: Faris M; Ensoli B; Kokot N; Nel A E
Inflammatory cytokines induce the expression of basic fibroblast growth factor (bFGF) isoforms required for the growth of Kaposi's sarcoma and endothelial cells through the activation of AP-1 response elements in the bFGF promoter.
AIDS (London, England) 1998;12(1):19-27.
1997: Casillas A M; Nel A E
An update on the immunopathogenesis of asthma as an inflammatory disease enhanced by environmental pollutants.
Allergy and asthma proceedings : the official journal of regional and state allergy societies 1997;18(4):227-33.
1997: Faris M; Kokot N; Stahl N; Nel A E
Involvement of Stat3 in interleukin-6-induced IgM production in a human B-cell line.
Immunology 1997;90(3):350-7.
1996: Faris M; Kokot N; Lee L; Nel A E
Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in jurkat T cells. Evidence for the importance of Ras in a pathway that is controlled by dual receptor stimulation.
The Journal of biological chemistry 1996;271(44):27366-73.
1996: Faris M; Ensoli B; Stahl N; Yancopoulos G; Nguyen A; Wang S; Nel A E
Differential activation of the extracellular signal-regulated kinase, Jun kinase and Janus kinase-Stat pathways by oncostatin M and basic fibroblast growth factor in AIDS-derived Kaposi's sarcoma cells.
AIDS (London, England) 1996;10(4):369-78.
1995: Fenghao X; Saxon A; Nguyen A; Ke Z; Diaz-Sanchez D; Nel A
Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-gamma activation site-like sequence upstream of the I epsilon exon in a human B cell line. Evidence for the involvement of Janus kinase 3 and interleukin-4 Stat.
The Journal of clinical investigation 1995;96(2):907-14.
1995: Nel A E; Gupta S; Lee L; Ledbetter J A; Kanner S B
Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR.
The Journal of biological chemistry 1995;270(31):18428-36.
1995: Kumar G; Wang S; Gupta S; Nel A
The membrane immunoglobulin receptor utilizes a Shc/Grb2/hSOS complex for activation of the mitogen-activated protein kinase cascade in a B-cell line.
The Biochemical journal 1995;307 ( Pt 1)():215-23.
1995: Targan S R; Deem R L; Liu M; Wang S; Nel A
Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):664-75.
1994: Kumar G; Gupta S; Wang S; Nel A E
Involvement of Janus kinases, p52shc, Raf-1, and MEK-1 in the IL-6-induced mitogen-activated protein kinase cascade of a growth-responsive B cell line.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4436-47.
1994: Gupta S; Weiss A; Kumar G; Wang S; Nel A
The T-cell antigen receptor utilizes Lck, Raf-1, and MEK-1 for activating mitogen-activated protein kinase. Evidence for the existence of a second protein kinase C-dependent pathway in an Lck-negative Jurkat cell mutant.
The Journal of biological chemistry 1994;269(25):17349-57.
1994: Nel A E; Taylor L K; Kumar G P; Gupta S; Wang S C; Williams K; Liao O; Swanson K; Landreth G E
Activation of a novel serine/threonine kinase that phosphorylates c-Fos upon stimulation of T and B lymphocytes via antigen and cytokine receptors.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(9):4347-57.
1993: Amaral M C; Miles S; Kumar G; Nel A E
Oncostatin-M stimulates tyrosine protein phosphorylation in parallel with the activation of p42MAPK/ERK-2 in Kaposi's cells. Evidence that this pathway is important in Kaposi cell growth.
The Journal of clinical investigation 1993;92(2):848-57.
1993: Daeipour M; Kumar G; Amaral M C; Nel A E
Recombinant IL-6 activates p42 and p44 mitogen-activated protein kinases in the IL-6 responsive B cell line, AF-10.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):4743-53.
1993: Amaral M C; Casillas A M; Nel A E
Contrasting effects of two tumour promoters, phorbol myristate acetate and okadaic acid, on T-cell responses and activation of p42 MAP-kinase/ERK-2.
Immunology 1993;79(1):24-31.
1993: Fairhurst R M; Daeipour M; Amaral M C; Nel A E
Activation of mitogen-activated protein kinase/ERK-2 in phytohaemagglutin in blasts by recombinant interleukin-2: contrasting features with CD3 activation.
Immunology 1993;79(1):112-8.
1993: Casillas A M; Amaral K; Chegini-Farahani S; Nel A E
Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate.
The Biochemical journal 1993;290 ( Pt 2)():545-50.
1993: Sydora B C; Mixter P F; Holcombe H R; Eghtesady P; Williams K; Amaral M C; Nel A; Kronenberg M
Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(6):2179-91.
1992: Raines M A; Golde D W; Daeipour M; Nel A E
Granulocyte-macrophage colony-stimulating factor activates microtubule-associated protein 2 kinase in neutrophils via a tyrosine kinase-dependent pathway.
Blood 1992;79(12):3350-4.
1991: Casillas A; Hanekom C; Williams K; Katz R; Nel A E
Stimulation of B-cells via the membrane immunoglobulin receptor or with phorbol myristate 13-acetate induces tyrosine phosphorylation and activation of a 42-kDa microtubule-associated protein-2 kinase.
The Journal of biological chemistry 1991;266(28):19088-94.
1991: Nel A E; Hanekom C; Hultin L
Protein kinase C plays a role in the induction of tyrosine phosphorylation of lymphoid microtubule-associated protein-2 kinase. Evidence for a CD3-associated cascade that includes pp56lck and that is defective in HPB-ALL.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(6):1933-9.
1991: Pollack S; Ledbetter J A; Katz R; Williams K; Akerley B; Franklin K; Schieven G; Nel A E
Evidence for involvement of glycoprotein-CD45 phosphatase in reversing glycoprotein-CD3-induced microtubule-associated protein-2 kinase activity in Jurkat T-cells.
The Biochemical journal 1991;276 ( Pt 2)():481-5.
1991: Nel A E; Ledbetter J A; Williams K; Ho P; Akerley B; Franklin K; Katz R
Activation of MAP-2 kinase activity by the CD2 receptor in Jurkat T cells can be reversed by CD45 phosphatase.
Immunology 1991;73(2):129-33.
1990: Hofmann B; Nishanian P; Baldwin R L; Insixiengmay P; Nel A; Fahey J L
HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(11):3699-705.
1990: Nel A E; Pollack S; Landreth G; Ledbetter J A; Hultin L; Williams K; Katz R; Akerley B
CD-3-mediated activation of MAP-2 kinase can be modified by ligation of the CD4 receptor. Evidence for tyrosine phosphorylation during activation of this kinase.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(3):971-9.
1990: Nel A E; Hanekom C; Rheeder A; Williams K; Pollack S; Katz R; Landreth G E
Stimulation of MAP-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(7):2683-9.
1989: Shephard E G; Beer S M; Anderson R; Strachan A F; Nel A E; de Beer F C
Generation of biologically active C-reactive protein peptides by a neutral protease on the membrane of phorbol myristate acetate-stimulated neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(9):2974-81.
1989: Hanekom C; Nel A; Gittinger C; Rheeder A; Landreth G
Complexing of the CD-3 subunit by a monoclonal antibody activates a microtubule-associated protein 2 (MAP-2) serine kinase in Jurkat cells.
The Biochemical journal 1989;262(2):449-56.
1988: Nel A E; Vandenplas M; Wooten M M; Cooper R; Vandenplas S; Rheeder A; Daniels J
Cholera toxin partially inhibits the T-cell response to phytohaemagglutinin through the ADP-ribosylation of a 45 kDa membrane protein.
The Biochemical journal 1988;256(2):383-90.
1988: Anderson R; Beyers A D; Savage J E; Nel A E
Apparent involvement of phospholipase A2, but not protein kinase C, in the pro-oxidative interactions of clofazimine with human phagocytes.
Biochemical pharmacology 1988;37(24):4635-41.
1988: Beyers A D; Hanekom C; Rheeder A; Strachan A F; Wooten M W; Nel A E
Characterization of protein kinase C and its isoforms in human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3463-70.
1988: Nel A E; De Beer M C; Shephard E G; Strachan A F; Vandenplas M L; De Beer F C
Phosphorylation of human serum amyloid A protein by protein kinase C.
The Biochemical journal 1988;255(1):29-34.
1988: Schwalb G; Beyers A D; Anderson R; Nel A E
Promotion of DNA strand breaks in cocultured mononuclear leukocytes by protein kinase C-dependent prooxidative interactions of benoxaprofen, human polymorphonuclear leukocytes, and ultraviolet radiation.
Cancer research 1988;48(11):3094-9.
1987: Anderson R; Lukey P T; Dippenaar U; Eftychis H A; Findlay G H; Wooten M W; Nel A E
Dithranol mediates pro-oxidative inhibition of polymorphonuclear leukocyte migration and lymphocyte proliferation.
The British journal of dermatology 1987;117(4):405-18.
1987: Nel A E; Schabort I; Rheeder A; Bouic P; Wooten M W
Inhibition of antibodies to CD3 surface antigen and phytohemagglutinin-mediated T cellular responses by inhibiting Ca2+/phospholipid-dependent protein kinase activity with the aid of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(7):2230-6.
1987: Nel A E; Wooten M W; Galbraith R M
Molecular signaling mechanisms in T-lymphocyte activation pathways: a review and future prospects.
Clinical immunology and immunopathology 1987;44(2):167-86.
1987: Krayer J W; Emerson D L; Goldschmidt-Clermont P J; Nel A E; Werner P A; Galbraith R M
Qualitative and quantitative studies of Gc (vitamin D-binding protein) in normal subjects and patients with periodontal disease.
Journal of periodontal research 1987;22(4):259-63.
1987: Nel A E; Bouic P; Lattanze G R; Stevenson H C; Miller P; Dirienzo W; Stefanini G F; Galbraith R M
Reaction of T lymphocytes with anti-T3 induces translocation of C-kinase activity to the membrane and specific substrate phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(10):3519-24.
1986: Stefanini G F; Dirienzo W; Arnaud P; Nel A; Canonica G W; Fudenberg H H
Inhibitory effect of an antibody against alpha 1-acid glycoprotein (alpha 1-AGP) on autologous mixed lymphocyte reaction and anti-T3 T-lymphocyte activation.
Cellular immunology 1986;103(1):65-72.
1986: Goldschmidt-Clermont P J; Van Alstyne E L; Day J R; Emerson D L; Nel A E; Lazarchick J; Galbraith R M
Group-specific component (vitamin D binding protein) prevents the interaction between G-actin and profilin.
Biochemistry 1986;25(21):6467-72.
1986: Nel A E; Dirienzo W; Stefanini G F; Wooten M W; Canonica G W; Lattanze G R; Stevenson H C; Miller P; Fudenberg H H; Galbraith R M
Inhibition of T3 mediated T-cell proliferation by Ca2+-channel blockers and inhibitors of Ca2+/phospholipid-dependent kinase.
Scandinavian journal of immunology 1986;24(3):283-90.
1986: Goldschmidt-Clermont P J; Allen R C; Nel A E; Emerson D L; Day J R; Galbraith R M
Gc (vitamin D-binding protein) binds the 33.5 K tryptic fragment of actin.
Life sciences 1986;38(8):735-42.
1986: Nel A E; Wooten M W; Landreth G E; Goldschmidt-Clermont P J; Stevenson H C; Miller P J; Galbraith R M
Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin.
The Biochemical journal 1986;233(1):145-9.
1985: Nel A E; Navailles M; Rosberger D F; Landreth G E; Goldschmidt-Clermont P J; Baldwin G J; Galbraith R M
Phorbol ester induces tyrosine phosphorylation in normal and abnormal human B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(5):3448-53.
1985: Nel A E; Navailles M; Emerson D L; Goldschmidt-Clermont P; Pathak S K; Tsang K Y; Galbraith R M
Altered configuration of Gc on the plasma membrane of transformed and malignant human B lymphocytes.
Clinical immunology and immunopathology 1985;37(2):191-202.
1985: Wooten M W; Nel A E; Goldschmidt-Clermont P J; Galbraith R M; Wrenn R W
Identification of a major endogenous substrate for phospholipid/Ca2+-dependent kinase in pancreatic acini as Gc (vitamin D-binding protein).
FEBS letters 1985;191(1):97-101.
1985: Goldschmidt-Clermont P J; Galbraith R M; Emerson D L; Werner P A; Nel A E; Lee W M
Accurate quantitation of native Gc in serum and estimation of endogenous Gc: G-actin complexes by rocket immunoelectrophoresis.
Clinica chimica acta; international journal of clinical chemistry 1985;148(3):173-83.
1985: Goldschmidt-Clermont P J; Galbraith R M; Emerson D L; Marsot F; Nel A E; Arnaud P
Distinct sites on the G-actin molecule bind group-specific component and deoxyribonuclease I.
The Biochemical journal 1985;228(2):471-7.
1985: Nel A E; Wooten M W; Goldschmidt-Clermont P J; Miller P J; Stevenson H C; Galbraith R M
Polymyxin B causes coordinate inhibition of phorbol ester-induced C-kinase activity and proliferation of B lymphocytes.
Biochemical and biophysical research communications 1985;128(3):1364-72.
1985: Petrini M; Galbraith R M; Emerson D L; Nel A E; Arnaud P
Structural studies of T lymphocyte Fc receptors. Association of Gc protein with IgG binding to Fc gamma.
The Journal of biological chemistry 1985;260(3):1804-10.
1985: Nel A E; Strachan A F; Welke H E; de Beer F C
Acute phase response in bronchiectasis and bronchus carcinoma.
Respiration; international review of thoracic diseases 1985;47(3):196-200.
1984: Nel A E; Landreth G E; Goldschmidt-Clermont P J; Tung H E; Galbraith R M
Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin.
Biochemical and biophysical research communications 1984;125(3):859-66.
1984: de Beer F C; Nel A E; Gie R P; Donald P R; Strachan A F
Serum amyloid A protein and C-reactive protein levels in pulmonary tuberculosis: relationship to amyloidosis.
Thorax 1984;39(3):196-200.
1984: Nel A E; Strachan A F; Welke H E; de Beer F C
Acute phase response in bronchiectasis and bronchus carcinoma.
Respiration; international review of thoracic diseases 1984;45(4):406-10.

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