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Cristina Bellucci

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Francesca Orlandi; Maria Novella Romanelli; Milena Salerno; Serena Scapecchi; Ivan Bello; Cristina Bellucci; Marcella Coronnello; Silvia Dei; Luca Guandalini; Dina Manetti; Cecilia Martelli; Hayette Menif; Enrico Mini; Elisabetta Teodori
New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).
Serena Scapecchi; Marta Nesi; Rosanna Matucci; Cristina Bellucci; Michela Buccioni; Silvia Dei; Luca Guandalini; Dina Manetti; Cecilia Martelli; Elisabetta Martini; Gabriella Marucci; Francesca Orlandi; Maria Novella Romanelli; Elisabetta Teodori; Roberto Cirilli
Synthesis, affinity profile and functional activity of potent chiral muscarinic antagonists with a pyrrolidinylfuran structure.
Anna Minarini; Gabriella Marucci; Cristina Bellucci; Gianluca Giorgi; Vincenzo Tumiatti; Maria Laura Bolognesi; Riccardo Matera; Michela Rosini; Carlo Melchiorre
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics.

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All Publications

2013: Francesca Orlandi; Maria Novella Romanelli; Milena Salerno; Serena Scapecchi; Ivan Bello; Cristina Bellucci; Marcella Coronnello; Silvia Dei; Luca Guandalini; Dina Manetti; Cecilia Martelli; Hayette Menif; Enrico Mini; Elisabetta Teodori
New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).
Bioorganic & medicinal chemistry 2013;21(2):456-65.
2010: Serena Scapecchi; Marta Nesi; Rosanna Matucci; Cristina Bellucci; Michela Buccioni; Silvia Dei; Luca Guandalini; Dina Manetti; Cecilia Martelli; Elisabetta Martini; Gabriella Marucci; Francesca Orlandi; Maria Novella Romanelli; Elisabetta Teodori; Roberto Cirilli
Synthesis, affinity profile and functional activity of potent chiral muscarinic antagonists with a pyrrolidinylfuran structure.
Journal of medicinal chemistry 2010;53(1):201-7.
2008: Anna Minarini; Gabriella Marucci; Cristina Bellucci; Gianluca Giorgi; Vincenzo Tumiatti; Maria Laura Bolognesi; Riccardo Matera; Michela Rosini; Carlo Melchiorre
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics.
Bioorganic & medicinal chemistry 2008;16(15):7311-20.
2007: Silvia Dei; Cristina Bellucci; Michela Buccioni; Marta Ferraroni; Luca Guandalini; Dina Manetti; Elisabetta Martini; Gabriella Marucci; Rosanna Matucci; Marta Nesi; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori
Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure.
Journal of medicinal chemistry 2007;50(6):1409-13.
2007: Vincenzo Tumiatti; Anna Minarini; Andrea Milelli; Michela Rosini; Michela Buccioni; Gabriella Marucci; Carla Ghelardini; Cristina Bellucci; Carlo Melchiorre
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.
Bioorganic & medicinal chemistry 2007;15(6):2312-21.
2006: Serena Scapecchi; Rosanna Matucci; Cristina Bellucci; Michela Buccioni; Silvia Dei; Luca Guandalini; Cecilia Martelli; Dina Manetti; Elisabetta Martini; Gabriella Marucci; Marta Nesi; Maria Novella Romanelli; Elisabetta Teodori; Fulvio Gualtieri
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.
Journal of medicinal chemistry 2006;49(6):1925-31.
2005: Silvia Dei; Piero Angeli; Cristina Bellucci; Michela Buccioni; Fulvio Gualtieri; Gabriella Marucci; Dina Manetti; Rosanna Matucci; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives.
Biochemical pharmacology 2005;69(11):1637-45.
2004: Serena Scapecchi; Elisabetta Martini; Cristina Bellucci; Michela Buccioni; Silvia Dei; Luca Guandalini; Dina Manetti; Cecilia Martelli; Gabriella Marucci; Rosanna Matucci
Molecular modulation of muscarinic antagonists. Synthesis and affinity profile of 2,2-diphenyl-2-ethylthio-acetic acid esters designed to probe the binding site cavity.
Farmaco (Società chimica italiana : 1989) 2004;59(12):971-80.
2004: Elisabetta Teodori; Elisabetta Baldi; Silvia Dei; Fulvio Gualtieri; Maria Novella Romanelli; Serena Scapecchi; Cristina Bellucci; Carla Ghelardini; Rosanna Matucci
Design, synthesis, and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain.
Journal of medicinal chemistry 2004;47(24):6070-81.
2003: Silvia Dei; Cristina Bellucci; Michela Buccioni; Marta Ferraroni; Fulvio Gualtieri; Luca Guandalini; Dina Manetti; Rosanna Matucci; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori
Synthesis and cholinergic affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)- pyrrolidine, 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their iodomethylates.
Bioorganic & medicinal chemistry 2003;11(14):3153-64.
2001: Serena Scapecchi; Gabriella Marucci; Rosanna Matucci; Piero Angeli; Cristina Bellucci; Michela Buccioni; Silvia Dei; Fulvio Gualtieri; Dina Manetti; Maria Novella Romanelli; Elisabetta Teodori
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists.
Bioorganic & medicinal chemistry 2001;9(5):1165-74.
2000: Dina Manetti; Carla Ghelardini; Alessandro Bartolini; Cristina Bellucci; Silvia Dei; Nicoletta Galeotti; Fulvio Gualtieri; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori
Design, synthesis, and preliminary pharmacological evaluation of 1, 4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents.
Journal of medicinal chemistry 2000;43(10):1969-74.
1999: Dina Manetti; Alessandro Bartolini; Pier Andrea Borea; Cristina Bellucci; Silvia Dei; Carla Ghelardini; Fulvio Gualtieri; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori; Katia Varani
Hybridized and isosteric analogues of N1-acetyl-N4-dimethyl-piperazinium iodide (ADMP) and N1-phenyl-N4-dimethyl-piperazinium iodide (DMPP) with central nicotinic action.
Bioorganic & medicinal chemistry 1999;7(3):457-65.
1999: Carla Ghelardini; Nicoletta Galeotti; Rosanna Matucci; Cristina Bellucci; Fulvio Gualtieri; Sergio Capaccioli; Alessandro Quattrone; Alessandro Bartolini
Antisense 'knockdowns' of M1 receptors induces transient anterograde amnesia in mice.
Neuropharmacology 1999;38(3):339-48.
1998: Serena Scapecchi; A Giorgi; Cristina Bellucci; Silvia Dei; Carla Ghelardini; Dina Manetti; Maria Novella Romanelli; Elisabetta Teodori
Further structure-activity relationships in the series of tropanyl esters endowed with potent antinociceptive activity.
Farmaco (Società chimica italiana : 1989) 1998;53(12):764-72.
1998: Carla Ghelardini; Nicoletta Galeotti; Fulvio Gualtieri; V Marchese; Cristina Bellucci; Alessandro Bartolini
Antinociceptive and antiamnesic properties of the presynaptic cholinergic amplifier PG-9.
The Journal of pharmacology and experimental therapeutics 1998;284(3):806-16.
1997: Carla Ghelardini; Nicoletta Galeotti; Fulvio Gualtieri; Cristina Bellucci; Dina Manetti; A Giotti; Petra Malmberg-Aiello; A Galli; Alessandro Bartolini
Antinociceptive profile of 3-alpha-tropanyl 2-(4-Cl-phenoxy)butyrate (SM-21) [corrected]: a novel analgesic with a presynaptic cholinergic mechanism of action.
The Journal of pharmacology and experimental therapeutics 1997;282(1):430-9.
1997: Carla Ghelardini; Alessandro Bartolini; Nicoletta Galeotti; Cristina Bellucci; Silvia Dei; Fulvio Gualtieri
In vitro characterization of a novel, potent and selective M3 antagonist.
Life sciences 1997;61(13):1217-26.
1996: Silvia Dei; Cristina Bellucci; Carla Ghelardini; Maria Novella Romanelli; santi spampinato
Synthesis, characterization and pharmacological profile of tropicamide enantiomers.
Life sciences 1996;58(23):2147-53.
1995: Silvia Dei; Cristina Bellucci; Fulvio Gualtieri; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori; Alessandro Bartolini; Carla Ghelardini
Analgesic, antimuscarinic activity and enantioselectivity of the four isomers of 3-quinuclidinyl tropate as compared with the enantiomers of hyoscyamine.
Farmaco (Società chimica italiana : 1989) 1995;50(5):303-9.
1989: Cristina Bellucci; Fulvio Gualtieri; Serena Scapecchi; Elisabetta Teodori; Roberta Budriesi; Alberto Chiarini
Negative inotropic and calcium antagonistic activity of alkyl and arylalkyl phosphonates.
Farmaco (Società chimica italiana : 1989) 1989;44(12):1167-91.
1985: Fulvio Gualtieri; Elisabetta Teodori; Cristina Bellucci; E Pesce; G Piacenza
SAR studies in the field of calcium(II) antagonists. Effect of modifications at the tetrasubstituted carbon of verapamil-like compounds.
Journal of medicinal chemistry 1985;28(11):1621-8.
1985: Cristina Bellucci; Elisabetta Teodori; Fulvio Gualtieri; G Piacenza
Search for new Ca++ antagonists. Lipophilic oximes and phosphonates.
Il Farmaco; edizione scientifica 1985;40(10):730-44.