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Yale Nemerson

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James J Hathcock; Elena Rusinova; Heikki Vaananen; Yale Nemerson
Lipid-bound factor Xa regulates tissue factor activity.
James J Hathcock; Elena Rusinova; Harry Andree; Yale Nemerson
Phospholipid surfaces regulate the delivery of substrate to tissue factor:VIIa and the removal of product.
Vladimir Y Bogdanov; R I Kirk; C Miller; James J Hathcock; S Vele; M Gazdoiu; Yale Nemerson; Mark B Taubman
Identification and characterization of murine alternatively spliced tissue factor.

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All Publications

2007: James J Hathcock; Elena Rusinova; Heikki Vaananen; Yale Nemerson
Lipid-bound factor Xa regulates tissue factor activity.
Biochemistry 2007;46(20):6134-40.
2006: James J Hathcock; Elena Rusinova; Harry Andree; Yale Nemerson
Phospholipid surfaces regulate the delivery of substrate to tissue factor:VIIa and the removal of product.
Blood cells, molecules & diseases 2006;36(2):194-8.
2006: Vladimir Y Bogdanov; R I Kirk; C Miller; James J Hathcock; S Vele; M Gazdoiu; Yale Nemerson; Mark B Taubman
Identification and characterization of murine alternatively spliced tissue factor.
Journal of thrombosis and haemostasis : JTH 2006;4(1):158-67.
2005: James J Hathcock; Yale Nemerson
Up against the wall.
Blood 2005;106(4):1505; author reply 1506-7.
2005: James J Hathcock; Elena Rusinova; Rodney D Gentry; Harry Andree; Yale Nemerson
Phospholipid regulates the activation of factor X by tissue factor/factor VIIa (TF/VIIa) via substrate and product interactions.
Biochemistry 2005;44(22):8187-97.
2005: Björn Szotowski; Petra Goldin-Lang; Silvio Antoniak; Vladimir Y Bogdanov; Delano Pathirana; Matthias Pauschinger; Andrea Dörner; Uwe Kuehl; Sarah E Coupland; Yale Nemerson; Michael Hummel; Wolfgang Poller; Roland Hetzer; Heinz-Peter Schultheiss; Ursula Rauch
Alterations in myocardial tissue factor expression and cellular localization in dilated cardiomyopathy.
Journal of the American College of Cardiology 2005;45(7):1081-9.
2004: James J Hathcock; Yale Nemerson
Platelet deposition inhibits tissue factor activity: in vitro clots are impermeable to factor Xa.
Blood 2004;104(1):123-7.
2004: Didier Moatti; Oana Vele; Yale Nemerson
Induction of fractalkine by endothelial cells under shear stress.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2004;15(2):197.
2003: Jacques Himber; C Wohlgensinger; S Roux; Lisa A Damico; John T Fallon; Daniel Kirchhofer; Yale Nemerson; Markus A Riederer
Inhibition of tissue factor limits the growth of venous thrombus in the rabbit.
Journal of thrombosis and haemostasis : JTH 2003;1(5):889-95.
2003: Vladimir Y Bogdanov; Viji Balasubramanian; James J Hathcock; Oana Vele; Mark Lieb; Yale Nemerson
Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein.
Nature medicine 2003;9(4):458-62.
2003: Antonia Sambola; Julio Osende; James J Hathcock; Michael Degen; Yale Nemerson; Valentin Fuster; Jill Crandall; Juan J Badimon
Role of risk factors in the modulation of tissue factor activity and blood thrombogenicity.
Circulation 2003;107(7):973-7.
2002: Viji Balasubramanian; Oana Vele; Yale Nemerson
Local shear conditions and platelet aggregates regulate the incorporation and activity of circulating tissue factor in ex-vivo thrombi.
Thrombosis and haemostasis 2002;88(5):822-6.
2002: Viji Balasubramanian; Eric Grabowski; Alessandra Bini; Yale Nemerson
Platelets, circulating tissue factor, and fibrin colocalize in ex vivo thrombi: real-time fluorescence images of thrombus formation and propagation under defined flow conditions.
Blood 2002;100(8):2787-92.
2002: Yale Nemerson
A simple experiment and a weakening paradigm: the contribution of blood to propensity for thrombus formation.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(9):1369.
2002: Jacques Himber; Dorothée Kling; John T Fallon; Yale Nemerson; Markus A Riederer
In situ localization of tissue factor in human thrombi.
Blood 2002;99(11):4249-50.
2002: Diana Bonderman; Alexander Teml; Johannes Jakowitsch; Christopher Adlbrecht; Mariann Gyöngyösi; Wolfgang Sperker; Harald Lass; Wilhelm Mosgoeller; Dietmar Glogar; Peter Probst; Gerald Maurer; Yale Nemerson; Irene M Lang
Coronary no-reflow is caused by shedding of active tissue factor from dissected atherosclerotic plaque.
Blood 2002;99(8):2794-800.
2001: William Konigsberg; Daniel Kirchhofer; Markus A Riederer; Yale Nemerson
The TF:VIIa complex: clinical significance, structure-function relationships and its role in signaling and metastasis.
Thrombosis and haemostasis 2001;86(3):757-71.
2000: Ursula Rauch; Yale Nemerson
Circulating tissue factor and thrombosis.
Current opinion in hematology 2000;7(5):273-7.
2000: Alison D Schecter; B Spirn; M Rossikhina; peter giesen; Vladimir Y Bogdanov; John T Fallon; E A Fisher; Lynn M Schnapp; Yale Nemerson; Mark B Taubman
Release of active tissue factor by human arterial smooth muscle cells.
Circulation research 2000;87(2):126-32.
2000: Ursula Rauch; Diana Bonderman; B Bohrmann; Juan J Badimon; Jacques Himber; Markus A Riederer; Yale Nemerson
Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor.
Blood 2000;96(1):170-5.
2000: Yale Nemerson
Tissue factor in neutrophils.
Thrombosis and haemostasis 2000;83(6):802.
2000: Ursula Rauch; Yale Nemerson
Tissue factor, the blood, and the arterial wall.
Trends in cardiovascular medicine 2000;10(4):139-43.
2000: Yale Nemerson
A different view of thrombosis.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2000;11 Suppl 1():S1-2.
2000: peter giesen; BS Fyfe; John T Fallon; Merce Roque; Milton Mendlowitz; M Rossikhina; A Guha; Juan J Badimon; Yale Nemerson; Mark B Taubman
Intimal tissue factor activity is released from the arterial wall after injury.
Thrombosis and haemostasis 2000;83(4):622-8.
2000: peter giesen; Yale Nemerson
Tissue factor on the loose.
Seminars in thrombosis and hemostasis 2000;26(4):379-84.
1999: J Zemsky; Elena Rusinova; Yale Nemerson; L A Luck; J B Alexander Ross
Probing local environments of tryptophan residues in proteins: comparison of 19F nuclear magnetic resonance results with the intrinsic fluorescence of soluble human tissue factor.
Proteins 1999;37(4):709-16.
1999: Mark B Taubman; peter giesen; Alison D Schecter; Yale Nemerson
Regulation of the procoagulant response to arterial injury.
Thrombosis and haemostasis 1999;82(2):801-5.
1999: peter giesen; Ursula Rauch; B Bohrmann; D Kling; Mercè Roqué; John T Fallon; Juan J Badimon; Jacques Himber; Markus A Riederer; Yale Nemerson
Blood-borne tissue factor: another view of thrombosis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2311-5.
1999: Marina Camera; peter giesen; J Fallon; B M Aufiero; M Taubman; Elena Tremoli; Yale Nemerson
Cooperation between VEGF and TNF-alpha is necessary for exposure of active tissue factor on the surface of human endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(3):531-7.
1998: S David Gertz; John T Fallon; R Gallo; Mark B Taubman; Shmuel Banai; WL Barry; Lawrence W Gimple; Yale Nemerson; S Thiruvikraman; S S Naidu; James H Chesebro; V Fuster; Ian J Sarembock; Juan J Badimon
Hirudin reduces tissue factor expression in neointima after balloon injury in rabbit femoral and porcine coronary arteries.
Circulation 1998;98(6):580-7.
1998: Connie L Hall; Mark B Taubman; Yale Nemerson; Vincent T Turitto
Factor Xa generation at the surface of cultured rat vascular smooth muscle cells in an in vitro flow system.
Journal of biomechanical engineering 1998;120(4):484-90.
1998: Yale Nemerson; peter giesen
Some thoughts about localization and expression of tissue factor.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1998;9 Suppl 1():S45-7.
1997: Alison D Schecter; Barrett J Rollins; Y J Zhang; Israel F Charo; John T Fallon; M Rossikhina; peter giesen; Yale Nemerson; Mark B Taubman
Tissue factor is induced by monocyte chemoattractant protein-1 in human aortic smooth muscle and THP-1 cells.
The Journal of biological chemistry 1997;272(45):28568-73.
1997: Alison D Schecter; peter giesen; O Taby; C L Rosenfield; M Rossikhina; BS Fyfe; D Stave Kohtz; John T Fallon; Yale Nemerson; Mark B Taubman
Tissue factor expression in human arterial smooth muscle cells. TF is present in three cellular pools after growth factor stimulation.
The Journal of clinical investigation 1997;100(9):2276-85.
1997: Robert D McBane; Randall S Miller; Nancy L Hassinger; James H Chesebro; Yale Nemerson; Whyte G Owen
Tissue prothrombin. Universal distribution in smooth muscle.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2430-6.
1997: Mark B Taubman; John T Fallon; Alison D Schecter; peter giesen; Milton Mendlowitz; BS Fyfe; J D Marmur; Yale Nemerson
Tissue factor in the pathogenesis of atherosclerosis.
Thrombosis and haemostasis 1997;78(1):200-4.
1997: Vincenzo Toschi; R Gallo; Maddalena Lettino; John T Fallon; S David Gertz; A Fernández-Ortiz; James H Chesebro; Lina Badimon; Yale Nemerson; Valentin Fuster; Juan J Badimon
Tissue factor modulates the thrombogenicity of human atherosclerotic plaques.
Circulation 1997;95(3):594-9.
1996: O Taby; C L Rosenfield; V Bogdanov; Yale Nemerson; Mark B Taubman
Cloning of the rat tissue factor cDNA and promoter: identification of a serum-response region.
Thrombosis and haemostasis 1996;76(5):697-702.
1996: Yale Nemerson
Analysis of the kinetics of factor X activation by tissue factor-factor VIIA.
Haemostasis 1996;26 Suppl 4():98-101.
1996: S V Thiruvikraman; A Guha; J Roboz; Mark B Taubman; Yale Nemerson; J T Fallon
In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors VIIa and X.
Laboratory investigation; a journal of technical methods and pathology 1996;75(4):451-61.
1996: Jonathan D Marmur; S V Thiruvikraman; BS Fyfe; A Guha; Samin K Sharma; John A Ambrose; J T Fallon; Yale Nemerson; Mark B Taubman
Identification of active tissue factor in human coronary atheroma.
Circulation 1996;94(6):1226-32.
1995: R Gentry; L Ye; Yale Nemerson
Surface-mediated enzymatic reactions: simulations of tissue factor activation of factor X on a lipid surface.
Biophysical journal 1995;69(2):362-71.
1995: R Gentry; L Ye; Yale Nemerson
A microscopic model of enzyme kinetics.
Biophysical journal 1995;69(2):356-61.
1995: Yale Nemerson
Tissue factor: then and now.
Thrombosis and haemostasis 1995;74(1):180-4.
1995: Harry Andree; Yale Nemerson
Tissue factor: regulation of activity by flow and phospholipid surfaces.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1995;6(3):189-97.
1995: Yale Nemerson
Life at the transport rate limit.
Seminars in hematology 1995;32(2):126-9.
1995: Yale Nemerson
The function of factor VIIa in hemophilia A: an hypothesis.
Advances in experimental medicine and biology 1995;386():157-61.
1994: Charles J Lockwood; Graciela Krikun; Csaba Papp; S Aigner; Yale Nemerson; Frederick Schatz
Biological mechanisms underlying RU 486 clinical effects: inhibition of endometrial stromal cell tissue factor content.
The Journal of clinical endocrinology and metabolism 1994;79(3):786-90.
1994: Graciela Krikun; Charles J Lockwood; Xiao-Xuan Wu; X D Zhou; Seth Guller; C Calandri; A Guha; Yale Nemerson; Jacob H Rand
The expression of the placental anticoagulant protein, annexin V, by villous trophoblasts: immunolocalization and in vitro regulation.
Placenta 1994;15(6):601-12.
1994: P B Contino; C A Hasselbacher; J B Alexander Ross; Yale Nemerson
Use of an oriented transmembrane protein to probe the assembly of a supported phospholipid bilayer.
Biophysical journal 1994;67(3):1113-6.
1994: Harry Andree; P B Contino; D Repke; R Gentry; Yale Nemerson
Transport rate limited catalysis on macroscopic surfaces: the activation of factor X in a continuous flow enzyme reactor.
Biochemistry 1994;33(14):4368-74.
1994: P B Contino; Harry Andree; Yale Nemerson
Flow dependence of factor X activation by tissue factor-factor VIIa.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1994;45(1):81-90.
1993: Charles J Lockwood; Yale Nemerson; Graciela Krikun; VA Hausknecht; L Markiewicz; M Alvarez; Seth Guller; Frederick Schatz
Steroid-modulated stromal cell tissue factor expression: a model for the regulation of endometrial hemostasis and menstruation.
The Journal of clinical endocrinology and metabolism 1993;77(4):1014-9.
1993: Jonathan D Marmur; M Rossikhina; A Guha; BS Fyfe; Victor L Friedrich; Milton Mendlowitz; Yale Nemerson; Mark B Taubman
Tissue factor is rapidly induced in arterial smooth muscle after balloon injury.
The Journal of clinical investigation 1993;91(5):2253-9.
1993: E Waxman; William R Laws; Thomas M Laue; Yale Nemerson; J B Alexander Ross
Human factor VIIa and its complex with soluble tissue factor: evaluation of asymmetry and conformational dynamics by ultracentrifugation and fluorescence anisotropy decay methods.
Biochemistry 1993;32(12):3005-12.
1993: Mark B Taubman; Jonathan D Marmur; C L Rosenfield; A Guha; S Nichtberger; Yale Nemerson
Agonist-mediated tissue factor expression in cultured vascular smooth muscle cells. Role of Ca2+ mobilization and protein kinase C activation.
The Journal of clinical investigation 1993;91(2):547-52.
1993: Charles J Lockwood; Yale Nemerson; Seth Guller; Graciela Krikun; M Alvarez; VA Hausknecht; E Gurpide; Frederick Schatz
Progestational regulation of human endometrial stromal cell tissue factor expression during decidualization.
The Journal of clinical endocrinology and metabolism 1993;76(1):231-6.
1992: Yale Nemerson
The tissue factor pathway of blood coagulation.
Seminars in hematology 1992;29(3):170-6.
1992: E Waxman; J B Alexander Ross; Thomas M Laue; A Guha; S V Thiruvikraman; T C Lin; William Konigsberg; Yale Nemerson
Tissue factor and its extracellular soluble domain: the relationship between intermolecular association with factor VIIa and enzymatic activity of the complex.
Biochemistry 1992;31(16):3998-4003.
1991: Charles J Lockwood; R Bach; A Guha; X D Zhou; W A Miller; Yale Nemerson
Amniotic fluid contains tissue factor, a potent initiator of coagulation.
American journal of obstetrics and gynecology 1991;165(5 Pt 1):1335-41.
1991: Yale Nemerson; V T Turitto
The effect of flow on hemostasis and thrombosis.
Thrombosis and haemostasis 1991;66(3):272-6.
1991: P Contino; D Repke; Yale Nemerson
A continuous flow reactor system for the study of blood coagulation.
Thrombosis and haemostasis 1991;66(1):138-40.
1991: C H Gemmell; V T Turitto; Yale Nemerson
Factors affecting the interaction of tissue factor/factor VII with factor X in a heterogeneous tubular reactor.
Thrombosis and haemostasis 1991;65(2):139-43.
1990: C H Gemmell; G J Broze; V T Turitto; Yale Nemerson
Utilization of a continuous flow reactor to study the lipoprotein-associated coagulation inhibitor (LACI) that inhibits tissue factor.
Blood 1990;76(11):2266-71.
1990: C H Gemmell; Yale Nemerson; V Turitto
The effects of shear rate on the enzymatic activity of the tissue factor-factor VIIa complex.
Microvascular research 1990;40(3):327-40.
1990: D Repke; C H Gemmell; A Guha; V T Turitto; G J Broze; Yale Nemerson
Hemophilia as a defect of the tissue factor pathway of blood coagulation: effect of factors VIII and IX on factor X activation in a continuous-flow reactor.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7623-7.
1988: C H Gemmell; V T Turitto; Yale Nemerson
Flow as a regulator of the activation of factor X by tissue factor.
Blood 1988;72(4):1404-6.
1988: R Bach; W H Konigsberg; Yale Nemerson
Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine.
Biochemistry 1988;27(12):4227-31.
1988: Yale Nemerson
Tissue factor and hemostasis.
Blood 1988;71(1):1-8.
1987: Yale Nemerson
Tissue factor and the initiation of blood coagulation.
Advances in experimental medicine and biology 1987;214():83-94.
1986: R Bach; R Gentry; Yale Nemerson
Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine.
Biochemistry 1986;25(14):4007-20.
1986: Yale Nemerson; R Gentry
An ordered addition, essential activation model of the tissue factor pathway of coagulation: evidence for a conformational cage.
Biochemistry 1986;25(14):4020-33.
1985: Yale Nemerson; D Repke
Tissue factor accelerates the activation of coagulation factor VII: the role of a bifunctional coagulation cofactor.
Thrombosis research 1985;40(3):351-8.