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Kenneth Nephew

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Heejoon Chae; Seong-Whan Lee; Kenneth P Nephew; Jinwoo Park; Sun Kim
Comparative analysis using K-mer and K-flank patterns provides evidence for CpG island sequence evolution in mammalian genomes.
James W Antoon; Bridgette Collins-Burow; Steven Elliott; Elizabeth C Martin; Seungyoon Nam; Kenneth P Nephew; Ashley M Nitzchke; Lyndsay Vanhoy Rhodes; Virgilio A Salvo; Scott Wadsworth; Matthew E Burow
Inhibition of p38 mitogen-activated protein kinase alters microRNA expression and reverses epithelial-to-mesenchymal transition.
Gianpiero Di Leva; Marco Galasso; Michela Garofalo; Pierluigi Gasparini; Marilena V Iorio; Meng Li; Guido Marcucci; Kenneth P Nephew; Apollinaire Ngankeu; Gerard Nuovo; Danilo Perrotti; Claudia Piovan; Kimerly A Powell; Santhanam Ramasamy; Cristian Taccioli; Hansjuerg Alder; Laura Anderlucci; Brad Bolon; Anna Bratasz; Daniel Briskin; Douglas G Cheung; Carlo M Croce
Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status.

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2013: Heejoon Chae; Seong-Whan Lee; Kenneth P Nephew; Jinwoo Park; Sun Kim
Comparative analysis using K-mer and K-flank patterns provides evidence for CpG island sequence evolution in mammalian genomes.
Nucleic acids research 2013;41(9):4783-91.
2013: James W Antoon; Bridgette Collins-Burow; Steven Elliott; Elizabeth C Martin; Seungyoon Nam; Kenneth P Nephew; Ashley M Nitzchke; Lyndsay Vanhoy Rhodes; Virgilio A Salvo; Scott Wadsworth; Matthew E Burow
Inhibition of p38 mitogen-activated protein kinase alters microRNA expression and reverses epithelial-to-mesenchymal transition.
International journal of oncology 2013;42(4):1139-50.
2013: Gianpiero Di Leva; Marco Galasso; Michela Garofalo; Pierluigi Gasparini; Marilena V Iorio; Meng Li; Guido Marcucci; Kenneth P Nephew; Apollinaire Ngankeu; Gerard Nuovo; Danilo Perrotti; Claudia Piovan; Kimerly A Powell; Santhanam Ramasamy; Cristian Taccioli; Hansjuerg Alder; Laura Anderlucci; Brad Bolon; Anna Bratasz; Daniel Briskin; Douglas G Cheung; Carlo M Croce
Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status.
PLoS genetics 2013;9(3):e1003311.
2013: Curt Balch; Kenneth P Nephew
Epigenetic targeting therapies to overcome chemotherapy resistance.
Advances in experimental medicine and biology 2013;754():285-311.
2012: Hyungro Lee; Suresh Marru; Seungyoon Nam; Kenneth P Nephew; Patanachai Tangchaisin; Youngik Yang; Heejoon Chae; Donghoon Choi; Chathura Herath; Sun Kim
BioVLAB-MMIA: a cloud environment for microRNA and mRNA integrated analysis (MMIA) on Amazon EC2.
IEEE transactions on nanobioscience 2012;11(3):266-72.
2012: Melyssa R Bratton; Daniel E Frigo; John A McLachlan; Kenneth P Nephew; Chris Segar; Thomas E Wiese; Matthew E Burow
The organochlorine o,p'-DDT plays a role in coactivator-mediated MAPK crosstalk in MCF-7 breast cancer cells.
Environmental health perspectives 2012;120(9):1291-6.
2012: Yi-Te Yo; Mu-Hsien Yu; Curt Balch; Michael W Y Chan; Cheng-Chang Chang; Chi-Kuan Chen; Rui-Lan Huang; Tim Huang; Ya-Wen Lin; Kenneth P Nephew; Huey-Kang Sytwu; Yu-Chi Wang; Hung-Cheng Lai
Growth inhibition of ovarian tumor-initiating cells by niclosamide.
Molecular cancer therapeutics 2012;11(8):1703-12.
2012: Curt Balch; Brett Ballard; Man-Wook Hur; Alan Hyslop; Christina Melki; Kaleb Naegeli; Seungyoon Nam; Elizabeth Reilly; Kenneth P Nephew
A unique histone deacetylase inhibitor alters microRNA expression and signal transduction in chemoresistant ovarian cancer cells.
Cancer biology & therapy 2012;13(8):681-93.
2012: Daniela Matei; Jeanne Schilder; Changyu Shen; Yan Zeng; Alesha Arnold; William A Berry; Fang Fang; Hui-Ming (Tim) Huang; Kenneth P Nephew
Epigenetic resensitization to platinum in ovarian cancer.
Cancer research 2012;72(9):2197-205.
2012: Bu-Nam Jeon; Kyung-Sup Kim; Minjung Kim; Min-Kyeong Kim; Dong-In Koh; Kyung-Ryul Lee; Kenneth P Nephew; Juyong Yoon; Chae-Ok Yun; Kang-Yell Choi; Won-Il Choi; Sung-Yi Hong; Man-Wook Hur
KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A.
Cancer research 2012;72(5):1137-48.
2012: Baishen Chen; Ju Chen; Kevin J Cullen; Michael G House; Kenneth P Nephew; Zhongmin Guo
Role of neurofilament light polypeptide in head and neck cancer chemoresistance.
Molecular cancer research : MCR 2012;10(3):305-15.
2012: Seungyoon Nam; Sun Kim; Changhyuk Kwon; Xinghua Long; Kenneth P Nephew
An integrative analysis of cellular contexts, miRNAs and mRNAs reveals network clusters associated with antiestrogen-resistant breast cancer cells.
BMC genomics 2012;13():732.
2012: Heng-Yi Wu; Pengyue Zheng; Tim H M Huang; Guanglong Jiang; Yunlong Liu; Kenneth P Nephew; Lang Li
A modulator based regulatory network for ERα signaling pathway.
BMC genomics 2012;13 Suppl 6():S6.
2012: Mingxiang Teng; Guohua Wang; Yadong Wang; Tim H M Huang; Seongho Kim; Lang Li; Yunlong Liu; Kenneth P Nephew; Changyu Shen; Curt Balch
Empirical bayes model comparisons for differential methylation analysis.
Comparative and functional genomics 2012;2012():376706.
2012: James W Antoon; Barbara S Beckman; Steven Elliott; Rongye Lai; Elizabeth C Martin; Kenneth P Nephew; Ashley M Nitschke; Lyndsay V Rhodes; Virgilio A Salvo; Bin Shan; Amanda P Struckhoff; Nam Seung Yoon; Matthew E Burow
Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistance.
Scientific reports 2012;2():539.
2012: Mingxiang Teng; Yadong Wang; Curt Balch; Hui-Ming (Tim) Huang; Meng Li; Yunlong Liu; Kenneth P Nephew; Lang Li
The influence of cis-regulatory elements on DNA methylation fidelity.
PloS one 2012;7(3):e32928.
2012: Syreeta L Tilghman; Thomas E Wiese; Melyssa R Bratton; Meng Li; Elizabeth C Martin; John A McLachlan; Kenneth P Nephew; Lyndsay Vanhoy Rhodes; Chris Segar; Matthew E Burow
Endocrine disruptor regulation of microRNA expression in breast carcinoma cells.
PloS one 2012;7(3):e32754.
2012: Lyndsay Vanhoy Rhodes; Chris Segar; Matthew E Burow; Jennifer L Driver; Steven Elliott; Meng Li; Elizabeth C Martin; Seung Yoon Nam; Kenneth P Nephew; Ashley M Nitschke; Bridgette M Collins-Burow
The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells.
Oncology reports 2012;27(1):10-6.
2011: Dayong Wu; Chunpeng Zhang; Kenneth P Nephew; Yanping Shen; Qianben Wang
Androgen receptor-driven chromatin looping in prostate cancer.
Trends in endocrinology and metabolism: TEM 2011;22(12):474-80.
2011: Lyndsay Vanhoy Rhodes; Virgilio A Salvo; Chandra R Tate; Syreeta L Tilghman; Yun Zhu; Bridgette M Collins-Burow; Steven Elliott; Shannon E Muir; Kenneth P Nephew; Melyssa R Bratton; Matthew E Burow
Effects of SDF-1-CXCR4 signaling on microRNA expression and tumorigenesis in estrogen receptor-alpha (ER-α)-positive breast cancer cells.
Experimental cell research 2011;317(18):2573-81.
2011: Chunpeng Zhang; Debra L Zynger; Dayong Wu; Jindan Yu; Myles Brown; Hongyan Chen; Zhong Chen; Steven K Clinton; Jérôme Eeckhoute; Hui-Ming (Tim) Huang; Wei Li; Jun Luo; Kenneth P Nephew; Jennifer M Thomas-Ahner; Liguo Wang; Qianben Wang
Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer.
Cancer research 2011;71(21):6738-48.
2011: Sebastian Vaughan; Henning Walczak; Robert C Bast; Andy Berchuck; Jonathan S Berek; David D Bowtell; James D Brenton; George Coukos; Jermaine I Coward; Christopher C Crum; Ronny Drapkin; Dariush Etemadmoghadam; Michael Friedlander; Hani Gabra; Stan B Kaye; Ernst Lengyel; Douglas A Levine; Chris J Lord; Iain A McNeish; Usha Menon; Gordon B Mills; Kenneth P Nephew; Amit M Oza; Anil K Sood; Euan A Stronach; Frances R Balkwill
Rethinking ovarian cancer: recommendations for improving outcomes.
Nature reviews. Cancer 2011;11(10):719-25.
2011: M Danielle Bareford; Matthew E Burow; Nichola Cruickshanks; Paul B Fisher; Steven Grant; Hossein A Hamed; Richard G Moran; Kenneth P Nephew; Yong Tang; Paul Dent
Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells.
Autophagy 2011;7(10):1261-2.
2011: Baishen Chen; Kevin J Cullen; Michael G House; Kenneth P Nephew; Xi Rao; Zhongmin Guo
GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response.
Cancer letters 2011;309(1):37-45.
2011: M Danielle Bareford; Matthew E Burow; Nichola Cruickshanks; Patrick Eulitt; Paul B Fisher; Steven Grant; Hossein A Hamed; Nisan Hubbard; Richard G Moran; Kenneth P Nephew; Margaret A Park; Yong Tang; Gary Tye; Adly Yacoub; Paul Dent
Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells.
Cancer research 2011;71(14):4955-67.
2011: I-Wen Teng; Kuen-Daw Tsai; Shaw-Jenq Tsai; Min-Jen Tseng; Chi-Sheng Wu; Kun-Tu Yeh; Kenneth P Nephew; H Sunny Sun; Yu-Sun Chang; Pei-Yi Chu; Pei-Chi Hou; Shu-Huei Hsiao; Hui-Ming (Tim) Huang; Long-Bin Jeng; Victor X Jin; Kuan-Der Lee; Yu-Wei Leu
Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells.
Cancer research 2011;71(13):4653-63.
2011: Kun-Tu Yeh; Gary C W Chen; Lin-Yu Chen; Tze-Ho Chen; Yu-Hsin Chen; Jian-Liang Chou; Daniel E Deatherage; Hui-Ming (Tim) Huang; Yi-Wen Huang; Hung-Cheng Lai; Huey-Jen Lin; Ru-Inn Lin; Kenneth P Nephew; Her-Young Su; Pearlly S Yan; Hui-Wen Yang; Chia-Ming Yeh; Michael W Y Chan
Aberrant TGFβ/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer.
Epigenetics : official journal of the DNA Methylation Society 2011;6(6):727-39.
2011: Feng C Zhou; Yokesh Balaraman; MingXiang Teng; Yunlong Liu; Singh Rabindra; Kenneth P Nephew
Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation.
Alcoholism, clinical and experimental research 2011;35(4):735-46.
2011: X Rao; G Di Leva; M Li; F Fang; C Devlin; C Hartman-Frey; M E Burow; M Ivan; C M Croce; Kenneth P Nephew
MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways.
Oncogene 2011;30(9):1082-97.
2011: Lyndsay Vanhoy Rhodes; Sarah P Short; Nicole F Neel; Virgilio A Salvo; Yun Zhu; Steven Elliott; Yongkun Wei; Dihua Yu; Menghong Sun; Shannon E Muir; Juan P Fonseca; Melyssa R Bratton; Chris Segar; Syreeta Latatia Tilghman; Tammy Sobolik-Delmaire; Linda W Horton; Snjezana Zaja-Milatovic; Bridgette M Collins-Burow; Scott Wadsworth; Barbara S Beckman; Charles E Wood; Suzanne A W Fuqua; Kenneth P Nephew; Paul Dent; Rebecca A Worthylake; Tyler J Curiel; Mien-Chie Hung; Ann Richmond; Matthew Burow
Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer.
Cancer research 2011;71(2):603-13.
2011: Brian A Kennedy; Kenneth P Nephew; Binhua Tang; Michael W Y Chan; Daniel E Deatherage; Fei Gu; Hui-Ming (Tim) Huang; Victor X Jin
ChIP-seq defined genome-wide map of TGFβ/SMAD4 targets: implications with clinical outcome of ovarian cancer.
PloS one 2011;6(7):e22606.
2011: Changyu Shen; Todd C Skaar; Mingxiang Teng; Guohua Wang; Yadong Wang; Zhiping Wang; Pearlly Yan; Yuming Zhao; David A Flockhart; Hui-Ming (Tim) Huang; Yiwen Huang; Yunlong Liu; Kenneth P Nephew; Lang Li
A modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer.
BMC systems biology 2011;5():67.
2010: John Foley; Nicole K Nickerson; Seungyoon Nam; Kah Tan Allen; Jennifer L Gilmore; Kenneth P Nephew; David J Riese
EGFR signaling in breast cancer: bad to the bone.
Seminars in cell & developmental biology 2010;21(9):951-60.
2010: Clint Mitchell; Adly Yacoub; Hamed Hossein; Aditi Pandya Martin; M Danielle Bareford; Patrick Eulitt; Chen Yang; Kenneth P Nephew; Paul Dent
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.
Cancer biology & therapy 2010;10(9):903-17.
2010: Sharmila A Bapat; Victor Jin; Nicholas Berry; Curt Balch; Neeti Sharma; Nawneet Kurrey; Shu Zhang; Fang Fang; Xun Lan; Meng Li; Brian Kennedy; Robert M Bigsby; Hui-Ming (Tim) Huang; Kenneth P Nephew
Multivalent epigenetic marks confer microenvironment-responsive epigenetic plasticity to ovarian cancer cells.
Epigenetics : official journal of the DNA Methylation Society 2010;5(8):716-29.
2010: Fang Fang; Curt Balch; Jeanne Schilder; Timothy Breen; Shu Zhang; Changyu Shen; Lang Li; Carol Kulesavage; Anthony J Snyder; Kenneth P Nephew; Daniela E Matei
A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer.
Cancer 2010;116(17):4043-53.
2010: Curtis Balch; Hui-Ming (Tim) Huang; Daniela E Matei; Kenneth P Nephew
Role of epigenomics in ovarian and endometrial cancers.
Epigenomics 2010;2(3):419-47.
2010: Pei-Yin Hsu; Hang-Kai Hsu; Gregory A C Singer; Pearlly S Yan; Benjamin A T Rodriguez; Joseph C Liu; Yu-I Weng; Daniel E Deatherage; Zhong Chen; Julia S Pereira; Ricardo Lopez; Jose Russo; Qianben Wang; Coral A Lamartiniere; Kenneth P Nephew; Hui-Ming (Tim) Huang
Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping.
Genome research 2010;20(6):733-44.
2010: Mi Jeong Kwon; Sung-Su Kim; Yoon-La Choi; Hun Soon Jung; Curt Balch; Su-Hyeong Kim; Yong-Sang Song; Victor E Marquez; Kenneth P Nephew; Young Kee Shin
Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications.
Carcinogenesis 2010;31(6):974-83.
2010: Emily L Rickert; Sean Oriana; Cori Hartman-Frey; Xinghua Long; Timothy T Webb; Kenneth P Nephew; Ross V Weatherman
Synthesis and characterization of fluorescent 4-hydroxytamoxifen conjugates with unique antiestrogenic properties.
Bioconjugate chemistry 2010;21(5):903-10.
2010: Gianpiero Di Leva; Pierluigi Gasparini; Claudia Piovan; Apollinaire Ngankeu; Michela Garofalo; Cristian Taccioli; Marilena V Iorio; Meng Li; Stefano Volinia; Hansjuerg Alder; Tatsuya Nakamura; Gerard Nuovo; Yunlong Liu; Kenneth P Nephew; Carlo M Croce
MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer.
Journal of the National Cancer Institute 2010;102(10):706-21.
2010: Jian-Liang Chou; Her-Young Su; Lin-Yu Chen; Yu-Ping Liao; Corinna Hartman-Frey; Yi-Hui Lai; Hui-Wen Yang; Daniel E Deatherage; Chieh-Ti Kuo; Yi-Wen Huang; Pearlly S Yan; Shu-Huei Hsiao; Chien-Kuo Tai; Huey-Jen L Lin; Ramana V Davuluri; Tai-Kuang Chao; Kenneth P Nephew; Hui-Ming (Tim) Huang; Hung-Cheng Lai; Michael W Y Chan
Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer.
Laboratory investigation; a journal of technical methods and pathology 2010;90(3):414-25.
2010: Xinghua Long; Meiyun Fan; Kenneth P Nephew
Estrogen receptor-alpha-interacting cytokeratins potentiate the antiestrogenic activity of fulvestrant.
Cancer biology & therapy 2010;9(5):389-96.
2010: Daniela Matei; Kenneth P Nephew
Epigenetic therapies for chemoresensitization of epithelial ovarian cancer.
Gynecologic oncology 2010;116(2):195-201.
2010: Kasi McCune; Poornima Bhat-Nakshatri; Mangesh Thorat; Kenneth P Nephew; Sunil Badve; Harikrishna Nakshatri
Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet.
Cancer research 2010;70(2):685-96.
2010: Curtis Balch; Kenneth P Nephew
The role of chromatin, microRNAs, and tumor stem cells in ovarian cancer.
Cancer biomarkers : section A of Disease markers 2010;8(4-5):203-21.
2010: Jaesik Jeong; Lang Li; Yunlong Liu; Kenneth P Nephew; Hui-Ming (Tim) Huang; Changyu Shen
An empirical Bayes model for gene expression and methylation profiles in antiestrogen resistant breast cancer.
BMC medical genomics 2010;3():55.
2010: Guohua Wang; Yadong Wang; Changyu Shen; Yi-wen Huang; Kun Huang; Hui-Ming (Tim) Huang; Kenneth P Nephew; Lang Li; Yunlong Liu
RNA polymerase II binding patterns reveal genomic regions involved in microRNA gene regulation.
PloS one 2010;5(11):e13798.
2009: Aditi Pandya Martin; Clint Mitchell; Mohamed Rahmani; Kenneth P Nephew; Steven Grant; Paul Dent
Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy.
Cancer biology & therapy 2009;8(21):2084-96.
2009: Yunlong Liu; Yokesh Balaraman; Guohua Wang; Kenneth P Nephew; Feng C Zhou
Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation.
Epigenetics : official journal of the DNA Methylation Society 2009;4(7):500-11.
2009: Yi-Wen Huang; Rachel A Jansen; Enrica Fabbri; Dustin Potter; Sandya Liyanarachchi; Michael W Y Chan; Joseph C Liu; Anne P G Crijns; Robert Brown; Kenneth P Nephew; Ate G J van der Zee; David E Cohn; Pearlly S Yan; Hui-Ming (Tim) Huang; Huey-Jen L Lin
Identification of candidate epigenetic biomarkers for ovarian cancer detection.
Oncology reports 2009;22(4):853-61.
2009: Curt Balch; Fang Fang; Daniela Matei; Hui-Ming (Tim) Huang; Kenneth P Nephew
Minireview: epigenetic changes in ovarian cancer.
Endocrinology 2009;150(9):4003-11.
2009: Seungyoon Nam; Meng Li; Kwangmin Choi; Curtis Balch; Sun Kim; Kenneth P Nephew
MicroRNA and mRNA integrated analysis (MMIA): a web tool for examining biological functions of microRNA expression.
Nucleic acids research 2009;37(Web Server issue):W356-62.
2009: Ya-Ting Yang; Curt Balch; Samuel K Kulp; Michael R Mand; Kenneth P Nephew; Ching-Shih Chen
A rationally designed histone deacetylase inhibitor with distinct antitumor activity against ovarian cancer.
Neoplasia (New York, N.Y.) 2009;11(6):552-63, 3 p following 563.
2009: Fuxiao Xin; Meng Li; Curt Balch; Michael Thomson; Meiyun Fan; Yunlong Liu; Scott M Hammond; Sun Kim; Kenneth P Nephew
Computational analysis of microRNA profiles and their target genes suggests significant involvement in breast cancer antiestrogen resistance.
Bioinformatics (Oxford, England) 2009;25(4):430-4.
2009: Kenneth P Nephew
What will it take to obtain DNA methylation markers for early cervical cancer detection?
Gynecologic oncology 2009;112(2):291-2.
2009: Kenneth P Nephew; Curt Balch; Shu Zhang; Hui-Ming (Tim) Huang
Epigenetics and ovarian cancer.
Cancer treatment and research 2009;149():131-46.
2009: Huaxia Qin; Michael W Y Chan; Sandya Liyanarachchi; Curtis Balch; Dustin Potter; Irene J Souriraj; Alfred S L Cheng; Francisco J Agosto-Perez; Elena V Nikonova; Pearlly S Yan; Huey-Jen Lin; Kenneth P Nephew; Joel Saltz; Louise C Showe; Hui-Ming (Tim) Huang; Ramana V Davuluri
An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules.
BMC systems biology 2009;3():73.
2009: Meng Li; Curt Balch; John S Montgomery; Mikyoung Jeong; Jae Hoon Chung; Pearlly Yan; Hui-Ming (Tim) Huang; Sun Kim; Kenneth P Nephew
Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer.
BMC medical genomics 2009;2():34.
2009: Kenneth P Nephew; Curt Balch; David G Skalnik
Methyl group acceptance assay for the determination of global DNA methylation levels.
Methods in molecular biology (Clifton, N.J.) 2009;507():35-41.
2008: Michael Wy Chan; Yi-Wen Huang; Corinna Hartman-Frey; Chieh-Ti Kuo; Daniel Deatherage; Huaxia Qin; Alfred S L Cheng; Pearlly S Yan; Ramana V Davuluri; Hui-Ming (Tim) Huang; Kenneth P Nephew; Huey-Jen L Lin
Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer.
Neoplasia (New York, N.Y.) 2008;10(9):908-19.
2008: Meng Li; Hyun-il Henry Paik; Curt Balch; Yoosung Kim; Lang Li; Hui-Ming (Tim) Huang; Kenneth P Nephew; Sun Kim
Enriched transcription factor binding sites in hypermethylated gene promoters in drug resistant cancer cells.
Bioinformatics (Oxford, England) 2008;24(16):1745-8.
2008: Xinghua Long; Meiyun Fan; Robert M Bigsby; Kenneth P Nephew
Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms.
Molecular cancer therapeutics 2008;7(7):2096-108.
2008: Nicholas B Berry; Meiyun Fan; Kenneth P Nephew
Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome.
Molecular endocrinology (Baltimore, Md.) 2008;22(7):1535-51.
2008: Shu Zhang; Curt Balch; Michael W Chan; Hung-Cheng Lai; Daniela Matei; Jeanne M Schilder; Pearlly S Yan; Hui-Ming (Tim) Huang; Kenneth P Nephew
Identification and characterization of ovarian cancer-initiating cells from primary human tumors.
Cancer research 2008;68(11):4311-20.
2008: Bailin Tan; Xinghua Long; Harikrishna Nakshatri; Kenneth P Nephew; Robert M Bigsby
Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase.
Journal of molecular endocrinology 2008;40(5):199-210.
2008: Alfred S L Cheng; Aedín C Culhane; Michael W Y Chan; Chinnambally R Venkataramu; Mathias Ehrich; Aejaz Nasir; Benjamin A T Rodriguez; Joseph Liu; Pearlly S Yan; John Quackenbush; Kenneth P Nephew; Timothy J Yeatman; Hui-Ming (Tim) Huang
Epithelial progeny of estrogen-exposed breast progenitor cells display a cancer-like methylome.
Cancer research 2008;68(6):1786-96.
2008: Changhua Zhou; Ashley M Nitschke; Wei Xiong; Qiang Zhang; Yan Tang; Michael Bloch; Steven Elliott; Yun Zhu; Lindsey Bazzone; David Yu; Christopher B Weldon; Rachel Schiff; john alan mclachlan; Barbara Beckman; Thomas E Wiese; Kenneth P Nephew; Bin Shan; Matthew Burow; Guangdi Wang
Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype.
Breast cancer research : BCR 2008;10(6):R105.
2008: Weixing Feng; Yunlong Liu; Jiejun Wu; Kenneth P Nephew; Hui-Ming (Tim) Huang; Lang Li
A Poisson mixture model to identify changes in RNA polymerase II binding quantity using high-throughput sequencing technology.
BMC genomics 2008;9 Suppl 2():S23.
2008: Guohua Wang; Xin Wang; Yadong Wang; Jack Y Yang; Lang Li; Kenneth P Nephew; Howard J Edenberg; Feng C Zhou; Yunlong Liu
Identification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome.
BMC genomics 2008;9 Suppl 1():S19.
2008: S Kim; M Li; H Paik; Kenneth P Nephew; Huidong Shi; R Kramer; D Xu; Hui-Ming (Tim) Huang
Predicting DNA methylation susceptibility using CpG flanking sequences.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2008;():315-26.
2007: Curt Balch; Kenneth P Nephew; Hui-Ming (Tim) Huang; Sharmila A Bapat
Epigenetic "bivalently marked" process of cancer stem cell-driven tumorigenesis.
BioEssays : news and reviews in molecular, cellular and developmental biology 2007;29(9):842-5.
2007: Meiyun Fan; Emily L Rickert; Lei Chen; Syed A Aftab; Kenneth P Nephew; Ross V Weatherman
Characterization of molecular and structural determinants of selective estrogen receptor downregulators.
Breast cancer research and treatment 2007;103(1):37-44.
2007: Liguo Zhang; Kenneth P Nephew; Patricia J Gallagher
Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes.
The Journal of biological chemistry 2007;282(16):11795-804.
2007: Phillip H Abbosh; X Li; L Li; T A Gardner; C Kao; Kenneth P Nephew
A conditionally replicative, Wnt/beta-catenin pathway-based adenovirus therapy for anaplastic thyroid cancer.
Cancer gene therapy 2007;14(4):399-408.
2006: Meiyun Fan; Pearlly S Yan; Cori Hartman-Frey; Lei Chen; Henry Paik; Samuel L Oyer; Jonathan D Salisbury; Alfred S L Cheng; Lang Li; Phillip H Abbosh; Hui-Ming (Tim) Huang; Kenneth P Nephew
Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant.
Cancer research 2006;66(24):11954-66.
2006: Lang Li; Alfred S L Cheng; Victor X Jin; Henry H Paik; Meiyun Fan; Xiaoman Li; Wei Zhang; Jason Robarge; Curtis Balch; Ramana V Davuluri; Sun Kim; Hui-Ming (Tim) Huang; Kenneth P Nephew
A mixture model-based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-alpha.
Bioinformatics (Oxford, England) 2006;22(18):2210-6.
2006: Phillip H Abbosh; John S Montgomery; Jason A Starkey; Milos Novotny; Eleanor G Zuhowski; Merrill J Egorin; Annie P Moseman; Adam Golas; Kate M Brannon; Curtis Balch; Hui-Ming (Tim) Huang; Kenneth P Nephew
Dominant-negative histone H3 lysine 27 mutant derepresses silenced tumor suppressor genes and reverses the drug-resistant phenotype in cancer cells.
Cancer research 2006;66(11):5582-91.
2006: Susan Wei; Curtis Balch; Henry H Paik; Yoo-Sung Kim; Rae Lynn Baldwin; Sandya Liyanarachchi; Lang Li; Zailong Wang; Joseph C Wan; Ramana V Davuluri; Beth Y Karlan; Gillian Gifford; Robert Brown; Sun Kim; Hui-Ming (Tim) Huang; Kenneth P Nephew
Prognostic DNA methylation biomarkers in ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(9):2788-94.
2006: Xinghua Long; Kenneth P Nephew
Fulvestrant (ICI 182,780)-dependent interacting proteins mediate immobilization and degradation of estrogen receptor-alpha.
The Journal of biological chemistry 2006;281(14):9607-15.
2006: Alfred S L Cheng; Victor X Jin; Meiyun Fan; Laura T Smith; Sandya Liyanarachchi; Pearlly S Yan; Yu-Wei Leu; Michael W Y Chan; Christoph Plass; Kenneth P Nephew; Ramana V Davuluri; Hui-Ming (Tim) Huang
Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters.
Molecular cell 2006;21(3):393-404.
2005: Meiyun Fan; Annie Park; Kenneth P Nephew
CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha.
Molecular endocrinology (Baltimore, Md.) 2005;19(12):2901-14.
2005: Michael W Y Chan; Susan Wei; Ping Wen; Zailong Wang; Daniela Matei; Joseph C Liu; Sandya Liyanarachchi; Robert Brown; Kenneth P Nephew; Pearlly S Yan; Hui-Ming (Tim) Huang
Hypermethylation of 18S and 28S ribosomal DNAs predicts progression-free survival in patients with ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(20):7376-83.
2005: Curtis Balch; Pearlly Yan; Teresa Craft; Suzanne Young; David G Skalnik; Hui-Ming (Tim) Huang; Kenneth P Nephew
Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer.
Molecular cancer therapeutics 2005;4(10):1505-14.
2005: Phillip H Abbosh; Kenneth P Nephew
Multiple signaling pathways converge on beta-catenin in thyroid cancer.
Thyroid : official journal of the American Thyroid Association 2005;15(6):551-61.
2005: Chad A Reed; Amy K Berndtson; Kenneth P Nephew
Dose-dependent effects of 4-hydroxytamoxifen, the active metabolite of tamoxifen, on estrogen receptor-alpha expression in the rat uterus.
Anti-cancer drugs 2005;16(5):559-67.
2005: Lang Li; Huidong Shi; Constantin T Yiannoutsos; Hui-Ming (Tim) Huang; Kenneth P Nephew
Epigenetic hypothesis tests for methylation and acetylation in a triple microarray system.
Journal of computational biology : a journal of computational molecular cell biology 2005;12(3):370-90.
2005: Curtis Balch; John S Montgomery; Hyun-Il Paik; Sun Kim; Sun Kim; Hui-Ming (Tim) Huang; Kenneth P Nephew
New anti-cancer strategies: epigenetic therapies and biomarkers.
Frontiers in bioscience : a journal and virtual library 2005;10():1897-931.
2004: Yu-Wei Leu; Pearlly S Yan; Meiyun Fan; Victor X Jin; Joseph C Liu; Edward M Curran; Wade V Welshons; Susan Wei; Ramana V Davuluri; Christoph Plass; Kenneth P Nephew; Hui-Ming (Tim) Huang
Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer.
Cancer research 2004;64(22):8184-92.
2004: Curtis Balch; Hui-Ming (Tim) Huang; Robert Brown; Kenneth P Nephew
The epigenetics of ovarian cancer drug resistance and resensitization.
American journal of obstetrics and gynecology 2004;191(5):1552-72.
2004: Meiyun Fan; Harikrishna Nakshatri; Kenneth P Nephew
Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activation.
Molecular endocrinology (Baltimore, Md.) 2004;18(11):2603-15.
2004: Nicholas B Berry; Yong Mee Cho; Maureen A Harrington; Stephen D Williams; John Foley; Kenneth P Nephew
Transcriptional targeting in ovarian cancer cells using the human epididymis protein 4 promoter.
Gynecologic oncology 2004;92(3):896-904.
2004: Victor X Jin; Yu-Wei Leu; Sandya Liyanarachchi; Hao Sun; Meiyun Fan; Kenneth P Nephew; Hui-Ming (Tim) Huang; Ramana V Davuluri
Identifying estrogen receptor alpha target genes using integrated computational genomics and chromatin immunoprecipitation microarray.
Nucleic acids research 2004;32(22):6627-35.
2004: Robert M Bigsby; Andrea Caperell-Grant; Nicholas Berry; Kenneth P Nephew; Dennis Lubahn
Estrogen induces a systemic growth factor through an estrogen receptor-alpha-dependent mechanism.
Biology of reproduction 2004;70(1):178-83.
2003: Huidong Shi; Susan Wei; Yu-Wei Leu; Farahnaz Rahmatpanah; Joseph C Liu; Pearlly S Yan; Kenneth P Nephew; Hui-Ming (Tim) Huang
Triple analysis of the cancer epigenome: an integrated microarray system for assessing gene expression, DNA methylation, and histone acetylation.
Cancer research 2003;63(9):2164-71.
2003: Meiyun Fan; Robert M Bigsby; Kenneth P Nephew
The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2003;17(3):356-65.
2003: Kenneth P Nephew; Hui-Ming (Tim) Huang
Epigenetic gene silencing in cancer initiation and progression.
Cancer letters 2003;190(2):125-33.
2002: Jason A Bailey; Kenneth P Nephew
Strain differences in tamoxifen sensitivity of Sprague-Dawley and Fischer 344 rats.
Anti-cancer drugs 2002;13(9):939-47.
2002: Susan Wei; Chuan-Mu Chen; Gordon Strathdee; Jaturon Harnsomburana; Chi-Ren Shyu; Farahnaz Rahmatpanah; Huidong Shi; Shu-Wing Ng; Pearlly S Yan; Kenneth P Nephew; Robert Brown; Hui-Ming (Tim) Huang
Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2246-52.
2002: Meiyun Fan; Xinghua Long; Jason A Bailey; Chad A Reed; Elizabeth Osborne; Edward A Gize; Eric A Kirk; Robert M Bigsby; Kenneth P Nephew
The activating enzyme of NEDD8 inhibits steroid receptor function.
Molecular endocrinology (Baltimore, Md.) 2002;16(2):315-30.
2001: X Long; E A Gize; Kenneth P Nephew; Robert M Bigsby
Evidence for estrogenic contamination of the MAPK inhibitor PD98059.
Endocrinology 2001;142(12):5390-3.
2001: A Ahluwalia; Jean A Hurteau; Robert M Bigsby; Kenneth P Nephew
DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells.
Gynecologic oncology 2001;82(2):299-304.
2001: A Ahluwalia; P Yan; Jean A Hurteau; Robert M Bigsby; S H Jung; Hui-Ming (Tim) Huang; Kenneth P Nephew
DNA methylation and ovarian cancer. I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization.
Gynecologic oncology 2001;82(2):261-8.
2001: Horacio Cárdenas; KA Burke; Robert M Bigsby; William F Pope; Kenneth P Nephew
Estrogen receptor beta in the sheep ovary during the estrous cycle and early pregnancy.
Biology of reproduction 2001;65(1):128-34.
2001: X Long; KA Burke; Robert M Bigsby; Kenneth P Nephew
Effects of the xenoestrogen bisphenol A on expression of vascular endothelial growth factor (VEGF) in the rat.
Experimental biology and medicine (Maywood, N.J.) 2001;226(5):477-83.
2001: M Hlaing; K Nam; J Lou; William F Pope; Kenneth P Nephew
Evidence for expression of estrogen receptor cofactor messenger ribonucleic acid in the ovary and uterus of domesticated animals (sheep, cow and pig).
Life sciences 2001;68(12):1427-38.
2000: Kenneth P Nephew; S Ray; M Hlaing; A Ahluwalia; S D Wu; X Long; S M Hyder; Robert M Bigsby
Expression of estrogen receptor coactivators in the rat uterus.
Biology of reproduction 2000;63(2):361-7.
2000: KA Burke; D M Schroeder; R A Abel; S C Richardson; Robert M Bigsby; Kenneth P Nephew
Immunohistochemical detection of estrogen receptor alpha in male rat spinal cord during development.
Journal of neuroscience research 2000;61(3):329-37.
2000: Alvaro Puga; S J Barnes; C y Chang; H Zhu; Kenneth P Nephew; S A Khan; Howard G Shertzer
Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Biochemical pharmacology 2000;59(8):997-1005.
2000: Kenneth P Nephew; Elizabeth Osborne; R A Lubet; C J Grubbs; S A Khan
Effects of oral administration of tamoxifen, toremifene, dehydroepiandrosterone, and vorozole on uterine histomorphology in the rat.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 2000;223(3):288-94.
2000: X Long; Rosemary Steinmetz; Nira Ben-Jonathan; Andrea Caperell-Grant; P C Young; Kenneth P Nephew; Robert M Bigsby
Strain differences in vaginal responses to the xenoestrogen bisphenol A.
Environmental health perspectives 2000;108(3):243-7.
2000: Kenneth P Nephew; C M Choi; T C Polek; R McBride; Robert M Bigsby; S A Khan; Nader Husseinzadeh
Expression of fos and jun proto-oncogenes in benign versus malignant human uterine tissue.
Gynecologic oncology 2000;76(3):388-96.
2000: Kenneth P Nephew; X Long; Elizabeth Osborne; KA Burke; A Ahluwalia; Robert M Bigsby
Effect of estradiol on estrogen receptor expression in rat uterine cell types.
Biology of reproduction 2000;62(1):168-77.
1998: Kenneth P Nephew; C Q Sheeler; M D Dudley; S Gordon; S G Nayfield; S A Khan
Studies of dehydroepiandrosterone (DHEA) with the human estrogen receptor in yeast.
Molecular and cellular endocrinology 1998;143(1-2):133-42.
1997: DL Allen; NA Mitchner; T E Uveges; Kenneth P Nephew; S Khan; Nira Ben-Jonathan
Cell-specific induction of c-fos expression in the pituitary gland by estrogen.
Endocrinology 1997;138(5):2128-35.
1996: Kenneth P Nephew; T C Polek; S A Khan
Tamoxifen-induced proto-oncogene expression persists in uterine endometrial epithelium.
Endocrinology 1996;137(1):219-24.
1995: Kenneth P Nephew; G A Peters; S A Khan
Cellular localization of estradiol-induced c-fos messenger ribonucleic acid in the rat uterus: c-fos expression and uterine cell proliferation do not correlate strictly.
Endocrinology 1995;136(7):3007-15.
1994: Kenneth P Nephew; M Tang; S A Khan
Estrogen differentially affects c-jun expression in uterine tissue compartments.
Endocrinology 1994;134(4):1827-34.
1994: Kenneth P Nephew; Horacio Cárdenas; KE McClure; Troy L Ott; Fuller W Bazer; William F Pope
Effects of administration of human chorionic gonadotropin or progesterone before maternal recognition of pregnancy on blastocyst development and pregnancy in sheep.
Journal of animal science 1994;72(2):453-8.
1993: Kenneth P Nephew; D K Webb; K C Akcali; B C Moulton; S A Khan
Hormonal regulation and expression of the jun-D protooncogene in specific cell types of the rat uterus.
The Journal of steroid biochemistry and molecular biology 1993;46(3):281-7.
1993: Kenneth P Nephew; T C Polek; K C Akcali; S A Khan
The antiestrogen tamoxifen induces c-fos and jun-B, but not c-jun or jun-D, protooncogenes in the rat uterus.
Endocrinology 1993;133(1):419-22.
1993: Kenneth P Nephew; A E Whaley; Ronald K Christenson; Kazuhiko Imakawa
Differential expression of distinct mRNAs for ovine trophoblast protein-1 and related sheep type I interferons.
Biology of reproduction 1993;48(4):768-78.
1993: Michael L Day; S G Kurz; Kenneth P Nephew; M D Wright; Y Hu; S P Ford; William F Pope
Influence of catecholestradiol on short-lived corpora lutea in beef cows.
Domestic animal endocrinology 1993;10(2):95-102.
1993: Kazuhiko Imakawa; S D Helmer; Kenneth P Nephew; C S Meka; Ronald K Christenson
A novel role for GM-CSF: enhancement of pregnancy specific interferon production, ovine trophoblast protein-1.
Endocrinology 1993;132(4):1869-71.
1992: Kenneth P Nephew; S Xie; D M Broermann-Ridder; KE McClure; William F Pope
Influence of the embryo on intrauterine migration in sheep.
Journal of animal science 1992;70(6):1911-5.
1991: Y Hu; Kenneth P Nephew; William F Pope; Michael L Day
Uterine influences on the formation of subnormal corpora lutea in seasonally anestrous ewes.
Journal of animal science 1991;69(6):2532-7.
1991: Kenneth P Nephew; KE McClure; Troy L Ott; D H Dubois; Fuller W Bazer; William F Pope
Relationship between variation in conceptus development and differences in estrous cycle duration in ewes.
Biology of reproduction 1991;44(3):536-9.
1990: Kenneth P Nephew; KE McClure; Michael L Day; S Xie; R M Roberts; William F Pope
Effects of intramuscular administration of recombinant bovine interferon-alpha I1 during the period of maternal recognition of pregnancy.
Journal of animal science 1990;68(9):2766-70.
1990: S Xie; D M Broermann; Kenneth P Nephew; R D Geisert; William F Pope
Ovulation and early embryogenesis in swine.
Biology of reproduction 1990;43(2):236-40.
1990: Y Hu; M D Wright; R M Dyer; Kenneth P Nephew; R P Bolze; M L Day
Effects of cloprostenol sodium and clenbuterol HCl on reproductive performance in postpartum anestrous cows.
Theriogenology 1990;34(1):127-32.
1990: S Xie; D M Broermann; Kenneth P Nephew; M D Bishop; William F Pope
Relationship between oocyte maturation and fertilization on zygotic diversity in swine.
Journal of animal science 1990;68(7):2027-33.
1990: D M Broermann; S Xie; Kenneth P Nephew; W F Pope
Limitations of oviductal transfers in swine.
Theriogenology 1990;33(3):709-21.
1990: S Xie; D M Broermann; Kenneth P Nephew; Joseph S Ottobre; Michael L Day; William F Pope
Changes in follicular endocrinology during final maturation of porcine oocytes.
Domestic animal endocrinology 1990;7(1):75-82.
1990: William F Pope; S Xie; D M Broermann; Kenneth P Nephew
Causes and consequences of early embryonic diversity in pigs.
Journal of reproduction and fertility. Supplement 1990;40():251-60.
1989: Kenneth P Nephew; S P Ford; Michael L Day; William F Pope
Extension of short cycles in postpartum beef cows by intrauterine treatment with catecholestradiol.
Domestic animal endocrinology 1989;6(4):363-70.
1989: D M Broermann; S Xie; Kenneth P Nephew; William F Pope
Effects of the oviduct and wheat germ agglutinin on enzymatic digestion of porcine zona pellucidae.
Journal of animal science 1989;67(5):1324-9.
1989: Kenneth P Nephew; KE McClure; William F Pope
Embryonic migration relative to maternal recognition of pregnancy in sheep.
Journal of animal science 1989;67(4):999-1005.
1988: Joy L Pate; Kenneth P Nephew
Effects of in vivo and in vitro administration of prostaglandin F2 alpha on lipoprotein utilization in cultured bovine luteal cells.
Biology of reproduction 1988;38(3):568-76.
1987: Joy L Pate; Kenneth P Nephew; G S Zarle
Cell density influences hormonal responsiveness but not lipoprotein utilization in cultured bovine luteal cells.
Molecular and cellular endocrinology 1987;53(3):187-94.