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Diane Nepomuceno

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Pascal Bonaventure; Nicholas I Carruthers; Wenying Chai; Peter De Boer; Jianing Di; Wilhelmus Drinkenburg; Christine Dugovic; Curt A Dvorak; Lisa Dvorak; Ian Fraser; Michelle Kramer; Brian Lord; Diane Nepomuceno; Steve Sands; Jonathan Shelton; Jaskaran Singh; Sue Wilson; Abdellah Ahnaou; Leah Aluisio; Kirk Bertelsen; Timothy W Lovenberg
Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder.
Lily Alvarez-Jaimes; Miroslav Cik; S Timothy Motley; Diane Nepomuceno; James R Shoblock; Emily Stocking; Steven W Sutton; Pascal Bonaventure
In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency.
Devin M Swanson; Victoria D Wong; John R Atack; Pascal Bonaventure; Curt A Dvorak; Lisa K Dvorak; JIll Jablonowski; Timothy W Lovenberg; Kirsten Morton; Diane Nepomuceno; Dale A Rudolph; Mark Seierstad; Chandra Shah; Nicholas I Carruthers
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.

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All Publications

2012: Pascal Bonaventure; Nicholas I Carruthers; Wenying Chai; Peter De Boer; Jianing Di; Wilhelmus Drinkenburg; Christine Dugovic; Curt A Dvorak; Lisa Dvorak; Ian Fraser; Michelle Kramer; Brian Lord; Diane Nepomuceno; Steve Sands; Jonathan Shelton; Jaskaran Singh; Sue Wilson; Abdellah Ahnaou; Leah Aluisio; Kirk Bertelsen; Timothy W Lovenberg
Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder.
The Journal of pharmacology and experimental therapeutics 2012;342(2):429-40.
2012: Lily Alvarez-Jaimes; Miroslav Cik; S Timothy Motley; Diane Nepomuceno; James R Shoblock; Emily Stocking; Steven W Sutton; Pascal Bonaventure
In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency.
PloS one 2012;7(2):e30792.
2011: Devin M Swanson; Victoria D Wong; John R Atack; Pascal Bonaventure; Curt A Dvorak; Lisa K Dvorak; JIll Jablonowski; Timothy W Lovenberg; Kirsten Morton; Diane Nepomuceno; Dale A Rudolph; Mark Seierstad; Chandra Shah; Nicholas I Carruthers
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.
Bioorganic & medicinal chemistry letters 2011;21(18):5552-6.
2011: Dale A Rudolph; Curt A Dvorak; Lisa Dvorak; Diane Nepomuceno; Pascal Bonaventure; Timothy W Lovenberg; Nicholas I Carruthers
Novel tetrahydropyrido[3,2-c]pyrroles as 5-HT(7) antagonists.
Bioorganic & medicinal chemistry letters 2011;21(1):42-4.
2010: Alejandro Santillan; Kelly J McClure; Brett D Allison; Brian Lord; Jamin D Boggs; Kirsten L Morton; Anita M Everson; Diane Nepomuceno; Michael A Letavic; Alice Lee-Dutra; Timothy W Lovenberg; Nicholas I Carruthers; Cheryl A Grice
Indole- and benzothiophene-based histamine H3 antagonists.
Bioorganic & medicinal chemistry letters 2010;20(21):6226-30.
2010: Michael A Letavic; Leah Aluisio; John R Atack; Pascal Bonaventure; Nicholas I Carruthers; Christine Dugovic; Anita Everson; Mark A Feinstein; Ian C Fraser; Kenway Hoey; Xiaohui Jiang; John M Keith; Tatiana Koudriakova; Perry Leung; Brian Lord; Timothy W Lovenberg; Kiev S Ly; Kirsten L Morton; S Timothy Motley; Diane Nepomuceno; Michele Rizzolio; Raymond Rynberg; Kia Sepassi; Jonathan Shelton
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
Bioorganic & medicinal chemistry letters 2010;20(14):4210-4.
2010: Diane Nepomuceno; Steve Sutton; Jingxue Yu; Jessica Zhu; Changlu Liu; Timothy W Lovenberg; Pascal Bonaventure
Mutagenesis studies of neuropeptide S identify a suitable peptide tracer for neuropeptide S receptor binding studies and peptides selectively activating the I(107) variant of human neuropeptide S receptor.
European journal of pharmacology 2010;635(1-3):27-33.
2010: Emily M Stocking; Leah Aluisio; John R Atack; Pascal Bonaventure; Nicholas I Carruthers; Christine Dugovic; Anita Everson; Ian Fraser; Xiaohui Jiang; Perry Leung; Brian Lord; Kiev S Ly; Kirsten L Morton; Diane Nepomuceno; Chandravadan R Shah; Jonathan Shelton; Akinola Soyode-Johnson; Michael A Letavic
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.
Bioorganic & medicinal chemistry letters 2010;20(9):2755-60.
2010: James R Shoblock; Natalie Welty; Diane Nepomuceno; Brian Lord; Leah Aluisio; Ian Fraser; S Timothy Motley; Steve W Sutton; Kirsten Morton; Ruggero Galici; John R Atack; Lisa Dvorak; Devin M Swanson; Nicholas I Carruthers; Curt Dvorak; Timothy W Lovenberg; Pascal Bonaventure
In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor.
Psychopharmacology 2010;208(2):265-77.
2009: Changlu Liu; Chester Kuei; Steven Sutton; Jonathan Shelton; Jessica Zhu; Diane Nepomuceno; Mohammed Akhter Hossain; John D Wade; Ross A D Bathgate; Pascal Bonaventure; Timothy W Lovenberg
Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7.
Annals of the New York Academy of Sciences 2009;1160():31-7.
2008: Michael A Letavic; John M Keith; Kiev S Ly; Pascal Bonaventure; Mark A Feinstein; Brian Lord; Kirsten L Miller; S Timothy Motley; Diane Nepomuceno; Steven W Sutton; Nicholas I Carruthers
2-Aryloxymethylmorpholine histamine H(3) antagonists.
Bioorganic & medicinal chemistry letters 2008;18(21):5796-9.
2008: Brock T Shireman; Curt A Dvorak; Dale A Rudolph; Pascal Bonaventure; Diane Nepomuceno; Lisa Dvorak; Kirsten L Miller; Timothy W Lovenberg; Nicholas I Carruthers
2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists.
Bioorganic & medicinal chemistry letters 2008;18(6):2103-8.
2008: Kiev S Ly; Michael A Letavic; John M Keith; Jennifer M Miller; Emily M Stocking; Ann J Barbier; Pascal Bonaventure; Brian Lord; Xiaohui Jiang; Jamin D Boggs; Lisa Dvorak; Kirsten L Miller; Diane Nepomuceno; Sandy J Wilson; Nicholas I Carruthers
Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(1):39-43.
2007: Chester Kuei; Steven Sutton; Pascal Bonaventure; Cindy Pudiak; Jonathan Shelton; Jessica Zhu; Diane Nepomuceno; Jiejun Wu; Jingcai Chen; Fredrik Kamme; Mark Seierstad; Michael D Hack; Ross A D Bathgate; Mohammed Akhter Hossain; John D Wade; John Atack; Timothy W Lovenberg; Changlu Liu
R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.
The Journal of biological chemistry 2007;282(35):25425-35.
2005: Elo Eriste; Ake Norberg; Diane Nepomuceno; Chester Kuei; Fredrik Kamme; Da-Thao Tran; Kerstin Strupat; Hans Jörnvall; Changlu Liu; Timothy W Lovenberg; Rannar Sillard
A novel form of neurotensin post-translationally modified by arginylation.
The Journal of biological chemistry 2005;280(42):35089-97.
2005: Changlu Liu; Pascal Bonaventure; Steven W Sutton; Jingcai Chen; Chester Kuei; Diane Nepomuceno; Timothy W Lovenberg
Recent progress in relaxin-3-related research.
Annals of the New York Academy of Sciences 2005;1041():47-60.
2005: Pascal Bonaventure; Diane Nepomuceno; Kirsten Miller; Jingcai Chen; Chester Kuei; Fredrik Kamme; Da-Thao Tran; Timothy W Lovenberg; Changlu Liu
Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog.
European journal of pharmacology 2005;513(3):181-92.
2005: Changlu Liu; Chester Kuei; Steven Sutton; Jingcai Chen; Pascal Bonaventure; Jiejun Wu; Diane Nepomuceno; Fredrik Kamme; Da-Thao Tran; Jessica Zhu; Tracey Wilkinson; Ross A D Bathgate; Elo Eriste; Rannar Sillard; Timothy W Lovenberg
INSL5 is a high affinity specific agonist for GPCR142 (GPR100).
The Journal of biological chemistry 2005;280(1):292-300.
2005: Steven W Sutton; Pascal Bonaventure; Chester Kuei; Diane Nepomuceno; Jiejun Wu; Jessica Zhu; Timothy W Lovenberg; Changlu Liu
G-protein-coupled receptor (GPCR)-142 does not contribute to relaxin-3 binding in the mouse brain: further support that relaxin-3 is the physiological ligand for GPCR135.
Neuroendocrinology 2005;82(3-4):139-50.
2005: Changlu Liu; Jingcai Chen; Chester Kuei; Steven Sutton; Diane Nepomuceno; Pascal Bonaventure; Timothy W Lovenberg
Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.
Molecular pharmacology 2005;67(1):231-40.
2005: Jingcai Chen; Chester Kuei; Steven W Sutton; Pascal Bonaventure; Diane Nepomuceno; Elo Eriste; Rannar Sillard; Timothy W Lovenberg; Changlu Liu
Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species.
The Journal of pharmacology and experimental therapeutics 2005;312(1):83-95.
2004: JIll Jablonowski; Wenying Chai; Xiaobing Li; Dale A Rudolph; William V Murray; Mark A Youngman; Scott L Dax; Diane Nepomuceno; Pascal Bonaventure; Timothy W Lovenberg; Nicholas I Carruthers
Novel non-peptidic neuropeptide Y Y2 receptor antagonists.
Bioorganic & medicinal chemistry letters 2004;14(5):1239-42.
2004: Pascal Bonaventure; Diane Nepomuceno; Curt Mazur; Brian Lord; Dale A Rudolph; JIll Jablonowski; Nicholas I Carruthers; Timothy W Lovenberg
Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor.
The Journal of pharmacology and experimental therapeutics 2004;308(3):1130-7.
2004: Steven W Sutton; Pascal Bonaventure; Chester Kuei; Barbara Roland; Jingcai Chen; Diane Nepomuceno; Timothy W Lovenberg; Changlu Liu
Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing.
Neuroendocrinology 2004;80(5):298-307.
2004: Pascal Bonaventure; Diane Nepomuceno; L Hein; J Gregor Sutcliffe; Timothy W Lovenberg; Peter B Hedlund
Radioligand binding analysis of knockout mice reveals 5-hydroxytryptamine(7) receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with alpha(2) adrenergic receptors.
Neuroscience 2004;124(4):901-11.
2002: Pascal Bonaventure; Diane Nepomuceno; Annette Kwok; Wenying Chai; Xavier Langlois; René Hen; Kimberly Stark; Nicholas I Carruthers; Timothy W Lovenberg
Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice.
The Journal of pharmacology and experimental therapeutics 2002;302(1):240-8.
2001: Z Chen; Elo Eriste; AP Jonsson; Ake Norberg; Diane Nepomuceno; Timothy W Lovenberg; Tomas Bergman; S Efendic; Hans Jörnvall; Rannar Sillard
Ser(13)-phosphorylated PYY from porcine intestine with a potent biological activity.
FEBS letters 2001;492(1-2):119-22.
2000: James J McNally; Mark A Youngman; Timothy W Lovenberg; Diane Nepomuceno; S Wilson; Scott L Dax
N-acylated alpha-(3-pyridylmethyl)-beta-aminotetralin antagoinists of the human neuropeptide Y Y5 receptor.
Bioorganic & medicinal chemistry letters 2000;10(15):1641-3.
2000: Mark A Youngman; James J McNally; Timothy W Lovenberg; Allen B Reitz; N M Willard; Diane Nepomuceno; SJ Wilson; Jeffrey J Crooke; Daniel Rosenthal; Anil Vaidya; Scott L Dax
alpha-Substituted N-(sulfonamido)alkyl-beta-aminotetralins: potent and selective neuropeptide Y Y5 receptor antagonists.
Journal of medicinal chemistry 2000;43(3):346-50.
2000: James J McNally; Mark A Youngman; Timothy W Lovenberg; Diane Nepomuceno; SJ Wilson; Scott L Dax
N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl]amines: potent antagonists of human neuropeptide Y Y5 receptor.
Bioorganic & medicinal chemistry letters 2000;10(3):213-6.
1999: Elo Eriste; Ake Norberg; V Bonetto; Diane Nepomuceno; Timothy W Lovenberg; Rannar Sillard; Hans Jörnvall
A C-terminally elongated form of PHI from porcine intestine.
Cellular and molecular life sciences : CMLS 1999;56(7-8):709-13.