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Andreas Nerlich

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Peter H Killian; Emanuel Kronski; Katharina M Michalik; Andreas G Nerlich; Ulrich Pfeffer; Christian P Sommerhoff; Simonetta Astigiano; Ottavia Barbieri; Beatrice E Bachmeier
Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2.
Christoph J Siepe; Axel Stäbler; Ulrike Szeimies; Christoph Weiler; Elisabeth Haas; Franziska Heider; Wolfgang Hitzl; Andreas G Nerlich; Michael H Mayer
Influence of lumbar intervertebral disc degeneration on the outcome of total lumbar disc replacement: a prospective clinical, histological, X-ray and MRI investigation.
Christoph Weiler; Norbert Boos; T Kirchner; Andreas G Nerlich; M Schietzsch; K Wuertz
Age-related changes in human cervical, thoracal and lumbar intervertebral disc exhibit a strong intra-individual correlation.

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2012: Peter H Killian; Emanuel Kronski; Katharina M Michalik; Andreas G Nerlich; Ulrich Pfeffer; Christian P Sommerhoff; Simonetta Astigiano; Ottavia Barbieri; Beatrice E Bachmeier
Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2.
Carcinogenesis 2012;33(12):2507-19.
2012: Christoph J Siepe; Axel Stäbler; Ulrike Szeimies; Christoph Weiler; Elisabeth Haas; Franziska Heider; Wolfgang Hitzl; Andreas G Nerlich; Michael H Mayer
Influence of lumbar intervertebral disc degeneration on the outcome of total lumbar disc replacement: a prospective clinical, histological, X-ray and MRI investigation.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2012;21(11):2287-99.
2012: Christoph Weiler; Norbert Boos; T Kirchner; Andreas G Nerlich; M Schietzsch; K Wuertz
Age-related changes in human cervical, thoracal and lumbar intervertebral disc exhibit a strong intra-individual correlation.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2012;21 Suppl 6():S810-8.
2011: P Scheiermann; Florian Weis; I Rösch; R Huf; F Janner; S N Kunz; Andreas G Nerlich; Oliver Peschel
Unusual presentation of Streptococcus pneumoniae-induced septic shock 36 years after splenectomy.
Infection 2011;39(3):283-5.
2011: Thomas Liebscher; Mathias Haefeli; Karin Wuertz; Andreas G Nerlich; Norbert Boos
Age-related variation in cell density of human lumbar intervertebral disc.
Spine 2011;36(2):153-9.
2011: Christoph Weiler; Veronique Weiler; Karin Wuertz; Christoph J Siepe; Norbert Boos; Andreas Korge; Mercedes Lopez-Ramos; H Michael Mayer; Andreas G Nerlich
Histological analysis of surgical lumbar intervertebral disc tissue provides evidence for an association between disc degeneration and increased body mass index.
BMC research notes 2011;4():497.
2011: Marina Klawitter; Marco Mehr; Andreas G Nerlich; Lilian Quero; Jivko Stoyanov; Nikolaus Aebli; Alessando Bertolo; Norbert Boos; Juergen Klasen; Karin Wuertz
Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration.
Journal of negative results in biomedicine 2011;10():9.
2011: Lilian Quero; Marina Klawitter; Andreas G Nerlich; Massimo Leonardi; Norbert Boos; Karin Wuertz
Bupivacaine--the deadly friend of intervertebral disc cells?
The spine journal : official journal of the North American Spine Society 2011;11(1):46-53.
2010: Christoph Weiler; Andreas G Nerlich; Rainer Schaaf; Beatrice E Bachmeier; Karin Wuertz; Norbert Boos
Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2010;19(10):1761-70.
2010: Beatrice E Bachmeier; Peter Killian; Ulrich Pfeffer; Andreas G Nerlich
Novel aspects for the application of Curcumin in chemoprevention of various cancers.
Frontiers in bioscience (Scholar edition) 2010;2():697-717.
2009: Andreas G Nerlich; Oliver Peschel; Eduard Egarter-Vigl
New evidence for Otzi's final trauma.
Intensive care medicine 2009;35(6):1138-9.
2009: Beatrice E Bachmeier; Cristina M Iancu; Peter H Killian; Emanuel Kronski; Valentina Mirisola; Giovanna Angelini; Marianne Jochum; Andreas G Nerlich; Ulrich Pfeffer
Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells.
Molecular cancer 2009;8():129.
2008: Beatrice E Bachmeier; Andreas G Nerlich; Valentina Mirisola; Marianne Jochum; Ulrich Pfeffer
Lineage infidelity and expression of melanocytic markers in human breast cancer.
International journal of oncology 2008;33(5):1011-5.
2008: Beatrice E Bachmeier; Andreas G Nerlich; Helmut Rohrbach; Erwin D Schleicher; Ulrich Friess
Maillard products as biomarkers in cancer.
Annals of the New York Academy of Sciences 2008;1126():283-7.
2008: Beatrice E Bachmeier; Isabelle V Mohrenz; Valentina Mirisola; Erwin Schleicher; Francesco Romeo; Clara Höhneke; Marianne Jochum; Andreas G Nerlich; Ulrich Pfeffer
Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB.
Carcinogenesis 2008;29(4):779-89.
2007: Stefan Strasser; Albert Zink; Gerald Kada; Peter Hinterdorfer; Oliver Peschel; Wolfgang M Heckl; Andreas G Nerlich; Stefan Thalhammer
Age determination of blood spots in forensic medicine by force spectroscopy.
Forensic science international 2007;170(1):8-14.
2007: Andreas G Nerlich; Beatrice E Bachmeier
Paleopathology of malignant tumours supports the concept of human vulnerability to cancer.
Nature reviews. Cancer 2007;7(7):563.
2007: Guenther Paesold; Andreas G Nerlich; Norbert Boos
Biological treatment strategies for disc degeneration: potentials and shortcomings.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2007;16(4):447-68.
2007: Andreas G Nerlich; Beatrice E Bachmeier; Erwin Schleicher; Helmut Rohrbach; Guenther Paesold; Norbert Boos
Immunomorphological analysis of RAGE receptor expression and NF-kappaB activation in tissue samples from normal and degenerated intervertebral discs of various ages.
Annals of the New York Academy of Sciences 2007;1096():239-48.
2007: Beatrice E Bachmeier; Andreas G Nerlich; Christoph Weiler; Guenther Paesold; Marianne Jochum; Norbert Boos
Analysis of tissue distribution of TNF-alpha, TNF-alpha-receptors, and the activating TNF-alpha-converting enzyme suggests activation of the TNF-alpha system in the aging intervertebral disc.
Annals of the New York Academy of Sciences 2007;1096():44-54.
2007: Beatrice E Bachmeier; Andreas G Nerlich; Cristina M Iancu; Michele Cilli; Erwin Schleicher; Roberta Vené; Raffaella Dell'Eva; Marianne Jochum; Adriana Albini; Ulrich Pfeffer
The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;19(1-4):137-52.
2006: Andreas G Nerlich; Helmut Rohrbach; Beatrice E Bachmeier; Albert Zink
Malignant tumors in two ancient populations: An approach to historical tumor epidemiology.
Oncology reports 2006;16(1):197-202.
2006: Mathias Haefeli; Fabian Kalberer; Daniel Saegesser; Andreas G Nerlich; Norbert Boos; Guenther Paesold
The course of macroscopic degeneration in the human lumbar intervertebral disc.
Spine 2006;31(14):1522-31.
2005: Beatrice E Bachmeier; Helmut Rohrbach; Johann De Waal; Marianne Jochum; Andreas G Nerlich
Enhanced expression and activation of major matrix metalloproteinases in distinct topographic areas of invasive breast carcinomas.
International journal of oncology 2005;26(5):1203-7.
2005: Beatrice E Bachmeier; Adriana Albini; Roberta Vené; Roberto Benelli; Douglas M Noonan; Cora Weigert; Christoph Weiler; Ralf Lichtinghagen; Marianne Jochum; Andreas G Nerlich
Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines.
Experimental cell research 2005;305(1):83-98.
2005: Beatrice E Bachmeier; Roberta Vené; Cristina M Iancu; Ulrich Pfeffer; Barbara Mayer; Douglas M Noonan; Adriana Albini; Marianne Jochum; Andreas G Nerlich
Transcriptional control of cell density dependent regulation of matrix metalloproteinase and TIMP expression in breast cancer cell lines.
Thrombosis and haemostasis 2005;93(4):761-9.
2005: Beatrice E Bachmeier; Cristina M Iancu; Marianne Jochum; Andreas G Nerlich
Matrix metalloproteinases in cancer: comparison of known and novel aspects of their inhibition as a therapeutic approach.
Expert review of anticancer therapy 2005;5(1):149-63.
2005: Andreas G Nerlich; Beatrice E Bachmeier; Norbert Boos
Expression of fibronectin and TGF-beta1 mRNA and protein suggest altered regulation of extracellular matrix in degenerated disc tissue.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2005;14(1):17-26.
2005: Christoph Weiler; Andreas G Nerlich; Beatrice E Bachmeier; Norbert Boos
Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls.
Spine 2005;30(1):44-53; discussion 54.
2004: Hjalmar Hagedorn; Albert Zink; Ulrike Szeimies; Andreas G Nerlich
[Macroscopic and endoscopic examinations of the head and neck region in ancient Egyptian mummies].
HNO 2004;52(5):413-22.
2003: Andreas G Nerlich; Ulrich Sauer; Isabell Ruoss; Hjalmar Hagedorn
High frequency of TGF-beta-receptor-II mutations in microdissected tissue samples from laryngeal squamous cell carcinomas.
Laboratory investigation; a journal of technical methods and pathology 2003;83(8):1241-51.
2003: Andreas G Nerlich; Beatrice E Bachmeier; Albert Zink; Stefan Thalhammer; Eduard Egarter-Vigl
Otzi had a wound on his right hand.
Lancet 2003;362(9380):334.
2002: Norbert Boos; Sabine Weissbach; Helmut Rohrbach; Christoph Weiler; Kevin F Spratt; Andreas G Nerlich
Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science.
Spine 2002;27(23):2631-44.
2002: Andreas G Nerlich; Christoph Weiler; Jan Zipperer; Martin Narozny; Norbert Boos
Immunolocalization of phagocytic cells in normal and degenerated intervertebral discs.
Spine 2002;27(22):2484-90.
2002: Beatrice E Bachmeier; Isabell Ruoss; Hjalmar Hagedorn; Andreas G Nerlich
Molecular analysis of TGF-(beta)s and their receptors in human keratinocyte cell lines of different biological behaviour.
International journal of molecular medicine 2002;10(4):371-6.
2002: Andreas G Nerlich; Helmut Rohrbach; Albert Zink
[Paleopathology of ancient Egyptian mummies and skeletons. Investigations on the occurrence and frequency of specific diseases during various time periods in the necropolis of Thebes-West].
Der Pathologe 2002;23(5):379-85.
2002: Christoph Weiler; Andreas G Nerlich; J Zipperer; Beatrice E Bachmeier; Norbert Boos
2002 SSE Award Competition in Basic Science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2002;11(4):308-20.
2002: Hjalmar Hagedorn; Andreas G Nerlich
Analysis of sex-hormone-receptor expression in laryngeal carcinoma.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2002;259(4):205-10.
2002: Beatrice E Bachmeier; Andreas G Nerlich
Immunohistochemical pattern of cytokeratins and MMPs in human keratinocyte cell lines of different biological behaviour.
International journal of oncology 2002;20(3):495-9.
2001: Beatrice E Bachmeier; Andreas G Nerlich; Ralf Lichtinghagen; Christian P Sommerhoff
Matrix metalloproteinases (MMPs) in breast cancer cell lines of different tumorigenicity.
Anticancer research 2001;21(6A):3821-8.
2001: Hjalmar Hagedorn; A Elbertzhagen; Isabell Ruoss; Ulrich Sauer; Andreas G Nerlich
Immunohistochemical analysis of major TGF-beta isoforms and their receptors in laryngeal carcinomas.
Virchows Archiv : an international journal of pathology 2001;439(4):531-9.
2001: Hjalmar Hagedorn; U Sauer; Erwin D Schleicher; Andreas G Nerlich
Divergence in distribution and prognostic significance of major basement components in laryngeal carcinomas.
International journal of oncology 2001;18(5):1045-51.
2001: Albert Zink; U Reischl; H Wolf; Andreas G Nerlich; R Miller
Corynebacterium in ancient Egypt.
Medical history 2001;45(2):267-72.
2001: Albert Zink; Christian J Haas; U Reischl; Ulrike Szeimies; Andreas G Nerlich
Molecular analysis of skeletal tuberculosis in an ancient Egyptian population.
Journal of medical microbiology 2001;50(4):355-66.
2001: Hjalmar Hagedorn; Beatrice E Bachmeier; Andreas G Nerlich
Synthesis and degradation of basement membranes and extracellular matrix and their regulation by TGF-beta in invasive carcinomas (Review).
International journal of oncology 2001;18(4):669-81.
2000: Andreas G Nerlich; Albert Zink; Ulrike Szeimies; Hjalmar Hagedorn
Ancient Egyptian prosthesis of the big toe.
Lancet 2000;356(9248):2176-9.
2000: Albert Zink; U Reischl; H Wolf; Andreas G Nerlich
Molecular evidence of bacteremia by gastrointestinal pathogenic bacteria in an infant mummy from ancient Egypt.
Archives of pathology & laboratory medicine 2000;124(11):1614-8.
2000: Christian J Haas; Albert Zink; E Molńar; Ulrike Szeimies; U Reischl; A Marcsik; Yann Ardagna; Olivier Dutour; György Pálfi; Andreas G Nerlich
Molecular evidence for different stages of tuberculosis in ancient bone samples from Hungary.
American journal of physical anthropology 2000;113(3):293-304.
2000: H G Hagedorn; Andreas G Nerlich
Microvessel density and endothelial basement membrane composition in laryngeal squamous cell carcinomas.
Acta oto-laryngologica 2000;120(7):891-8.
2000: Christian J Haas; Albert Zink; György Pálfi; Ulrike Szeimies; Andreas G Nerlich
Detection of leprosy in ancient human skeletal remains by molecular identification of Mycobacterium leprae.
American journal of clinical pathology 2000;114(3):428-36.
2000: Beatrice E Bachmeier; Andreas G Nerlich; P Boukamp; Ralf Lichtinghagen; H Tschesche; Hans Fritz; Edwin Fink
Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and -13 and of TIMP-1.
Biological chemistry 2000;381(5-6):509-16.
1999: Albert Zink; Helmut Rohrbach; Ulrike Szeimies; Hjalmar Hagedorn; Christian J Haas; C Weyss; Beatrice E Bachmeier; Andreas G Nerlich
Malignant tumors in an ancient Egyptian population.
Anticancer research 1999;19(5B):4273-7.
1999: Annette Lebeau; Andreas G Nerlich; Ulrich Sauer; Ralf Lichtinghagen; Udo Löhrs
Tissue distribution of major matrix metalloproteinases and their transcripts in human breast carcinomas.
Anticancer research 1999;19(5B):4257-64.
1999: Andreas G Nerlich; Erwin D Schleicher
N(epsilon)-(carboxymethyl)lysine in atherosclerotic vascular lesions as a marker for local oxidative stress.
Atherosclerosis 1999;144(1):41-7.
1998: Andreas G Nerlich; Hjalmar Hagedorn; M Böheim; Erwin D Schleicher
Patients with diabetes-induced microangiopathy show a reduced frequency of carcinomas.
In vivo (Athens, Greece) 1998;12(6):667-70.
1998: Andreas G Nerlich; Annette Lebeau; Hjalmar Hagedorn; Ulrich Sauer; Erwin D Schleicher
Morphological aspects of altered basement membrane metabolism in invasive carcinomas of the breast and the larynx.
Anticancer research 1998;18(5A):3515-20.
1998: Hjalmar Hagedorn; M Schreiner; Irmi Wiest; J Tübel; Erwin D Schleicher; Andreas G Nerlich
Defective basement membrane in laryngeal carcinomas with heterogeneous loss of distinct components.
Human pathology 1998;29(5):447-54.
1998: Andreas G Nerlich; U Sauer; V Kolm-Litty; E Wagner; M Koch; Erwin D Schleicher
Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes.
Diabetes 1998;47(2):170-8.
1998: Hjalmar Hagedorn; J Tübel; Irmi Wiest; Andreas G Nerlich
In situ apoptotic and proliferation index in laryngeal squamous cell carcinomas.
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology 1998;16(3):177-84.
1998: Hjalmar Hagedorn; J Tübel; Irmi Wiest; Erwin D Schleicher; Andreas G Nerlich
Prognostic aspects of the loss of epithelial basement membrane components in preinvasive and invasive laryngeal carcinomas.
Anticancer research 1998;18(1A):201-7.
1998: Andreas G Nerlich; Peter Freisinger
Severe rhizomelic skeletal dysplasia in a museum skeleton.
Skeletal radiology 1998;27(1):46-9.
1998: Andreas G Nerlich; Norbert Boos; Irmi Wiest; M Aebi
Immunolocalization of major interstitial collagen types in human lumbar intervertebral discs of various ages.
Virchows Archiv : an international journal of pathology 1998;432(1):67-76.
1997: Andreas G Nerlich; Erwin D Schleicher; Norbert Boos
1997 Volvo Award winner in basic science studies. Immunohistologic markers for age-related changes of human lumbar intervertebral discs.
Spine 1997;22(24):2781-95.
1997: Norbert Boos; Andreas G Nerlich; Irmi Wiest; K von der Mark; M Aebi
Immunolocalization of type X collagen in human lumbar intervertebral discs during ageing and degeneration.
Histochemistry and cell biology 1997;108(6):471-80.
1997: Andreas G Nerlich; Christian J Haas; Albert Zink; Ulrike Szeimies; Hjalmar Hagedorn
Molecular evidence for tuberculosis in an ancient Egyptian mummy.
Lancet 1997;350(9088):1404.
1997: Andreas G Nerlich; Irmi Wiest; E Wagner; Ulrich Sauer; Erwin D Schleicher
Gene expression and protein deposition of major basement membrane components and TGF-beta 1 in human breast cancer.
Anticancer research 1997;17(6D):4443-9.
1997: Erwin D Schleicher; E Wagner; Andreas G Nerlich
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.
The Journal of clinical investigation 1997;99(3):457-68.
1996: Andreas G Nerlich; Peter Freisinger; Jacky Bonaventure
Radiological and histological variants of thanatophoric dysplasia are associated with common mutations in FGFR-3.
American journal of medical genetics 1996;63(1):155-60.
1996: S Haraida; Andreas G Nerlich; Irmi Wiest; Erwin D Schleicher; Udo Löhrs
Distribution of basement membrane components in normal adipose tissue and in benign and malignant tumors of lipomatous origin.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1996;9(2):137-44.
1995: Andreas G Nerlich; Irmi Wiest; Erwin D Schleicher
Localization of extracellular matrix components in congenital nephrotic syndromes.
Pediatric nephrology (Berlin, Germany) 1995;9(2):145-53.
1995: Andreas G Nerlich; F Parsche; Irmi Wiest; P Schramel; U Löhrs
Extensive pulmonary haemorrhage in an Egyptian mummy.
Virchows Archiv : an international journal of pathology 1995;427(4):423-9.
1994: Andreas G Nerlich; H Stöss; H Lehmann; T Krieg; P K Müller
Pathomorphological and biochemical alterations in Ehlers-Danlos-syndrome type IV.
Pathology, research and practice 1994;190(7):697-706; discussion 706-7.
1994: Andreas G Nerlich; Erwin D Schleicher; Irmi Wiest; U Specks; Rupert Timpl
Immunohistochemical localization of collagen VI in diabetic glomeruli.
Kidney international 1994;45(6):1648-56.
1994: Andreas G Nerlich; S Haraida; Irmi Wiest
Basement membrane components as differential markers for mesenchymal tumors of various origin.
Anticancer research 1994;14(2B):683-92.
1993: Andreas G Nerlich; F Parsche; Thorsten Kirsch; Irmi Wiest; Klaus von der Mark
Immunohistochemical detection of interstitial collagens in bone and cartilage tissue remnants in an infant Peruvian mummy.
American journal of physical anthropology 1993;91(3):279-85.
1993: Andreas G Nerlich; R E Brenner; Irmi Wiest; H Lehmann; C Yang; P K Müller; K von der Mark
Immunohistochemical localization of interstitial collagens in bone tissue from patients with various forms of osteogenesis imperfecta.
American journal of medical genetics 1993;45(2):258-9.
1993: Andreas G Nerlich; Irmi Wiest; Klaus von der Mark
Immunohistochemical analysis of interstitial collagens in cartilage of different stages of osteoarthrosis.
Virchows Archiv. B, Cell pathology including molecular pathology 1993;63(4):249-55.
1992: Andreas G Nerlich; Thorsten Kirsch; Irmi Wiest; P Betz; Klaus von der Mark
Localization of collagen X in human fetal and juvenile articular cartilage and bone.
Histochemistry 1992;98(5):275-81.
1992: Andreas G Nerlich; S Majewski; N Hunzelmann; R E Brenner; B Wiebecke; P K Müller; T Kreig; K Remberger
Excessive collagen formation in fibrolamellar carcinoma of the liver: a morphological and biochemical study.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1992;5(5):580-5.
1992: Andreas G Nerlich; R E Brenner; P K Müller; K Remberger
Multifocal osteogenic sarcoma of the skull in a patient who had congenital hyperphosphatasemic skeletal dysplasia. A case report.
The Journal of bone and joint surgery. American volume 1992;74(7):1090-5.
1992: S Haraida; Andreas G Nerlich; K Bise; Irmi Wiest; Erwin D Schleicher
Comparison of various basement membrane components in benign and malignant peripheral nerve tumours.
Virchows Archiv. A, Pathological anatomy and histopathology 1992;421(4):331-8.
1991: Andreas G Nerlich; Erwin D Schleicher
Identification of lymph and blood capillaries by immunohistochemical staining for various basement membrane components.
Histochemistry 1991;96(5):449-53.
1989: Erwin D Schleicher; E M Wagner; B Olgemöller; Andreas G Nerlich; Klaus-Dieter Gerbitz
Characterization and localization of basement membrane-associated heparan sulfate proteoglycan in human tissues.
Laboratory investigation; a journal of technical methods and pathology 1989;61(3):323-32.