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Claus Nerlov

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Natalija Buza-Vidas; Valeriu B Cismasiu; Sten Eirik W Jacobsen; Sidinh Luc; Michael Lutteropp; Adam J Mead; Luca Melchiori; Susan Moore; Deborah Atkinson; Tiphaine Bouriez-Jones; Donal O'Carroll; Petter S Woll; Claus Nerlov
Dicer is selectively important for the earliest stages of erythroid development.
Oxana Bereshchenko; Adriana Gambardella; Luisa Luciani; Elena Mancini; Carlo Riccardi; Claus Nerlov
Pontin is essential for murine hematopoietic stem cell survival.
K Reckzeh; M Rehn; Oxana Bereshchenko; Sten Eirik W Jacobsen; S Kharazi; A Mead; Claus Nerlov; Jörg Cammenga
Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.

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All Publications

2012: Natalija Buza-Vidas; Valeriu B Cismasiu; Sten Eirik W Jacobsen; Sidinh Luc; Michael Lutteropp; Adam J Mead; Luca Melchiori; Susan Moore; Deborah Atkinson; Tiphaine Bouriez-Jones; Donal O'Carroll; Petter S Woll; Claus Nerlov
Dicer is selectively important for the earliest stages of erythroid development.
Blood 2012;120(12):2412-6.
2012: Oxana Bereshchenko; Adriana Gambardella; Luisa Luciani; Elena Mancini; Carlo Riccardi; Claus Nerlov
Pontin is essential for murine hematopoietic stem cell survival.
Haematologica 2012;97(9):1291-4.
2012: K Reckzeh; M Rehn; Oxana Bereshchenko; Sten Eirik W Jacobsen; S Kharazi; A Mead; Claus Nerlov; Jörg Cammenga
Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.
Leukemia 2012;26(7):1527-36.
2012: Sidinh Luc; Tiago C Luis; Michael Lutteropp; Iain C Macaulay; Sahoko Matsuoka; Adam J Mead; Takuo Mizukami; Claus Nerlov; Roger Patient; Alejandra Sanjuan-Pla; Shamit Soneji; Petter S Woll; Stephen J Loughran; Kristina Anderson; Deborah Atkinson; Clare Blackburn; Hanane Boukarabila; Tiphaine Bouriez-Jones; John Brown; Natalija Buza-Vidas; Cintia Carella; Marella de Bruijn; Aniela Domanski; Sara Duarte; Tariq Enver; Alison Farley; Helen Ferry; Isabelle Godin; Anne Hultquist; Sten Eirik W Jacobsen
The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.
Nature immunology 2012;13(4):412-9.
2012: Elena Mancini; Susan Moore; Daniel Bilbao; Amit Grover; Sten Eirik Jacobsen; Sidinh Luc; Luisa Luciani; Donal O'Carroll; Kasper D Rasmussen; Alejandra Sanjuan-Pla; Agnes Zay; Claus Nerlov
FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors.
The EMBO journal 2012;31(2):351-65.
2012: Marie S Hasemann; Claus Nerlov; Thomas Å Pedersen; Mikkel Bruhn Schuster; Kim Theilgaard-Mönch; Anne-Katrine Frank; Bo T Porse
Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.
PloS one 2012;7(6):e38841.
2011: Shabnam Kharazi; Sidinh Luc; Zhi Ma; Anna Mansour; Kristina Masson; Adam J Mead; Claus Nerlov; Kristian Reckzeh; Lars Rönnstrand; Ewa Sitnicka; Toshio Suda; Fumio Arai; Debbie Atkinson; Charlotta Böiers; Natalija Buza-Vidas; Jörg Cammenga; Helen Ferry; Anne Hultquist; Sten Eirik W Jacobsen
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
Blood 2011;118(13):3613-21.
2011: Olga Ermakova; Lukasz Piszczek; Luisa Luciani; Florence M G Cavalli; Tiago Ferreira; Dominika Farley; Stefania Rizzo; Rosa Chiara Paolicelli; Mumna Banchaabouchi; Claus Nerlov; Richard Moriggl; Nicholas M Luscombe; Cornelius Gross
Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.
EMBO molecular medicine 2011;3(1):50-66.
2010: Claus Nerlov
Transcriptional and translational control of C/EBPs: the case for "deep" genetics to understand physiological function.
BioEssays : news and reviews in molecular, cellular and developmental biology 2010;32(8):680-6.
2009: Oxana Bereshchenko; Elena Mancini; Susan Moore; Daniel Bilbao; Robert Månsson; Sidinh Luc; Amit Grover; Sten Eirik W Jacobsen; David Bryder; Claus Nerlov
Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.
Cancer cell 2009;16(5):390-400.
2009: Ann-Marie Bröske; Lena Vockentanz; Shabnam Kharazi; Matthew Huska; Elena Mancini; Marina Scheller; Christiane Kuhl; Andreas Enns; Marco Prinz; Rudolf Jaenisch; Claus Nerlov; Achim Leutz; Miguel Andrade; Sten Eirik W Jacobsen; Frank Rosenbauer
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.
Nature genetics 2009;41(11):1207-15.
2009: Daniela Ruffell; Foteini Mourkioti; Adriana Gambardella; Peggy Kirstetter; Rodolphe G Lopez; Nadia Rosenthal; Claus Nerlov
A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(41):17475-80.
2009: Rodolphe G Lopez; Susana Garcia-Silva; Susan J Moore; Oksana Bereshchenko; Ana B Martinez-Cruz; Olga Ermakova; Elke Kurz; Jesus Paramio; Claus Nerlov
C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation.
Nature cell biology 2009;11(10):1181-90.
2009: Claus Nerlov
Targeting a chronic problem: elimination of cancer stem cells in CML.
The EMBO journal 2009;28(3):167-8.
2009: Francesca Diella; Sophie Chabanis; Katja Luck; Claudia Chica; Chenna Ramu; Claus Nerlov; Toby J Gibson
KEPE--a motif frequently superimposed on sumoylation sites in metazoan chromatin proteins and transcription factors.
Bioinformatics (Oxford, England) 2009;25(1):1-5.
2008: Joachim Weischenfeldt; Inge Damgaard; David Bryder; Kim Theilgaard-Mönch; Lina A Thoren; Omid Niazi; Sten Eirik W Jacobsen; Claus Nerlov; Bo T Porse
NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.
Genes & development 2008;22(10):1381-96.
2008: Jens Nygren; Karina Liuba; Martin Breitbach; Simon Stott; Lina Thorén; Wilhelm Roell; Caroline Geisen; Philipp Sasse; Deniz Kirik; Anders Björklund; Claus Nerlov; Bernd K Fleischmann; Stefan Jovinge; Sten Eirik W Jacobsen
Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.
Nature cell biology 2008;10(5):584-92.
2008: Marie S Hasemann; Inge Damgaard; Mikkel Bruhn Schuster; Kim Theilgaard-Mönch; Annette B Sørensen; Alan Mrsic; Thijs Krugers; Bauke Ylstra; Finn Skou Pedersen; Claus Nerlov; Bo T Porse
Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen.
Blood 2008;111(8):4309-21.
2008: Peggy Kirstetter; Mikkel B Schuster; Oksana Bereshchenko; Susan Moore; Heidi Dvinge; Elke Kurz; Kim Theilgaard-Mönch; Robert Månsson; Thomas A Pedersen; Thomas Pabst; Evelin Schrock; Bo T Porse; Sten Eirik W Jacobsen; Paul Bertone; Daniel G Tenen; Claus Nerlov
Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.
Cancer cell 2008;13(4):299-310.
2008: Claus Nerlov
C/EBPs: recipients of extracellular signals through proteome modulation.
Current opinion in cell biology 2008;20(2):180-5.
2007: Lars Nilsson; Patrik Edén; Eleonor Olsson; Robert Månsson; Ingbritt Astrand-Grundström; Bodil Strömbeck; Kim Theilgaard-Mönch; Kristina Anderson; Robert Hast; Eva Hellström-Lindberg; Jan Samuelsson; Gösta Bergh; Claus Nerlov; Bertil Johansson; Mikael Sigvardsson; Ake Borg; Sten Eirik W Jacobsen
The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes.
Blood 2007;110(8):3005-14.
2007: Claus Nerlov
The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control.
Trends in cell biology 2007;17(7):318-24.
2007: T Fujimoto; Kristina Anderson; S E W Jacobsen; S-I Nishikawa; Claus Nerlov
Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.
The EMBO journal 2007;26(9):2361-70.
2007: Kristina Anderson; Corinne Rusterholz; Robert Månsson; Christina T Jensen; Karl Bacos; Sasan Zandi; Yutaka Sasaki; Claus Nerlov; Mikael Sigvardsson; Sten Eirik W Jacobsen
Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes.
Blood 2007;109(9):3697-705.
2007: Thomas Askov Pedersen; Oxana Bereshchenko; Susana Garcia-Silva; Olga Ermakova; Elke Kurz; Susanne Mandrup; Bo T Porse; Claus Nerlov
Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo.
The EMBO journal 2007;26(4):1081-93.
2007: Anna Maria Calella; Claus Nerlov; Rodolphe G Lopez; Carla Sciarretta; Oliver von Bohlen und Halbach; Oksana Bereshchenko; Liliana Minichiello
Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription.
Neural development 2007;2():4.
2006: Peggy Kirstetter; Kristina Anderson; Bo T Porse; Sten Eirik W Jacobsen; Claus Nerlov
Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.
Nature immunology 2006;7(10):1048-56.
2006: Chu Wai Liew; Kasper D Rand; Raina J Y Simpson; Wendy W Yung; Robyn E Mansfield; Merlin Crossley; Mette Proetorius-Ibba; Claus Nerlov; Flemming M Poulsen; Joel Mackay
Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.
The Journal of biological chemistry 2006;281(38):28296-306.
2006: Bo T Porse; Thomas Askov Pedersen; Marie Sigurd Hasemann; Mikkel Bruhn Schuster; Peggy Kirstetter; Tom Luedde; Inge Damgaard; Elke Kurz; Charlotte Karlskov Schjerling; Claus Nerlov
The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo.
Molecular and cellular biology 2006;26(3):1028-37.
2005: Bo T Porse; David Bryder; Kim Theilgaard-Mönch; Marie S Hasemann; Kristina Anderson; Inge Damgaard; Sten Eirik W Jacobsen; Claus Nerlov
Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.
The Journal of experimental medicine 2005;202(1):85-96.
2005: Youssef BAKRI; Sandrine Sarrazin; Ulrich P Mayer; Silke Tillmanns; Claus Nerlov; Annie Boned; Michael H Sieweke
Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate.
Blood 2005;105(7):2707-16.
2004: Claus Nerlov
C/EBPalpha mutations in acute myeloid leukaemias.
Nature reviews. Cancer 2004;4(5):394-400.
2003: Francesco D'Alo'; Lisa M Johansen; Erik A Nelson; Hanna S Radomska; Erica K. Evans; Pu Zhang; Claus Nerlov; Daniel G Tenen
The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells.
Blood 2003;102(9):3163-71.
2003: Qian-fei Wang; Rebecca Cleaves; Tanawan Kummalue; Claus Nerlov; Alan D Friedman
Cell cycle inhibition mediated by the outer surface of the C/EBPalpha basic region is required but not sufficient for granulopoiesis.
Oncogene 2003;22(17):2548-57.
2003: Richard van Wijk; Wouter W van Solinge; Claus Nerlov; Ernest Beutler; Terri Gelbart; Gert Rijksen; Omid Niazi
Disruption of a novel regulatory element in the erythroid-specific promoter of the human PKLR gene causes severe pyruvate kinase deficiency.
Blood 2003;101(4):1596-602.
2002: Jens Pedersen-Bjergaard; Mette K Andersen; Debes H Christiansen; Claus Nerlov
Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia.
Blood 2002;99(6):1909-12.
2001: Thomas Askov Pedersen; Elisabeth Kowenz-Leutz; Achim Leutz; Claus Nerlov
Cooperation between C/EBPalpha TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation.
Genes & development 2001;15(23):3208-16.
2001: Bo T Porse; X Xu; B Lindberg; U M Wewer; L Friis-Hansen; Claus Nerlov
E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo.
Cell 2001;107(2):247-58.
2000: E Querfurth; M Schuster; H Kulessa; J D Crispino; G Döderlein; Stuart H Orkin; Thomas Graf; Claus Nerlov
Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors.
Genes & development 2000;14(19):2515-25.
2000: Claus Nerlov; E Querfurth; H Kulessa; Thomas Graf
GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription.
Blood 2000;95(8):2543-51.
1999: IJ Rourke; Thomas V O Hansen; Claus Nerlov; Jens F Rehfeld; Omid Niazi
Negative cooperativity between juxtaposed E-box and cAMP/TPA responsive elements in the cholecystokinin gene promoter.
FEBS letters 1999;448(1):15-8.
1998: Claus Nerlov; Kelly M McNagny; G Döderlein; Elisabeth Kowenz-Leutz; Thomas Graf
Distinct C/EBP functions are required for eosinophil lineage commitment and maturation.
Genes & development 1998;12(15):2413-23.
1998: Claus Nerlov; Thomas Graf
PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors.
Genes & development 1998;12(15):2403-12.
1998: Kelly M McNagny; Michael H Sieweke; G Döderlein; Thomas Graf; Claus Nerlov
Regulation of eosinophil-specific gene expression by a C/EBP-Ets complex and GATA-1.
The EMBO journal 1998;17(13):3669-80.