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Jørn Nerup

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Joanna M M Howson; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion Nierras; Flemming Pociot; Marian Rewers; Stephen S Rich; Jin-Xiong She; Deborah J Smyth; Helen Stevens; John A Todd; Neil M Walker; Beena Akolkar; Patrick Concannon; Jason D Cooper; George S Eisenbarth; Henry A Erlich
Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes.
Grant Morahan; Munish Mehta; Ian James; Wei-Min Chen; Beena Akolkar; Henry A Erlich; Joan E Hilner; Cécile Julier; Jørn Nerup; Concepcion Nierras; Flemming Pociot; John A Todd; Stephen S Rich
Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.
Stefanie Eising; Anita Nilsson; Bendix Carstensen; David M Hougaard; Bent Nørgaard-Pedersen; Jørn Nerup; Ake Lernmark; Flemming Pociot
Danish children born with glutamic acid decarboxylase-65 and islet antigen-2 autoantibodies at birth had an increased risk to develop type 1 diabetes.

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2012: Joanna M M Howson; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion Nierras; Flemming Pociot; Marian Rewers; Stephen S Rich; Jin-Xiong She; Deborah J Smyth; Helen Stevens; John A Todd; Neil M Walker; Beena Akolkar; Patrick Concannon; Jason D Cooper; George S Eisenbarth; Henry A Erlich
Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes.
Diabetes 2012;61(11):3012-7.
2011: Grant Morahan; Munish Mehta; Ian James; Wei-Min Chen; Beena Akolkar; Henry A Erlich; Joan E Hilner; Cécile Julier; Jørn Nerup; Concepcion Nierras; Flemming Pociot; John A Todd; Stephen S Rich
Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.
Diabetes 2011;60(3):1030-40.
2011: Stefanie Eising; Anita Nilsson; Bendix Carstensen; David M Hougaard; Bent Nørgaard-Pedersen; Jørn Nerup; Ake Lernmark; Flemming Pociot
Danish children born with glutamic acid decarboxylase-65 and islet antigen-2 autoantibodies at birth had an increased risk to develop type 1 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2011;164(2):247-52.
2010: Flemming Pociot; Beena Akolkar; Patrick Concannon; Henry A Erlich; Cécile Julier; Grant Morahan; Concepcion R Nierras; John A Todd; Stephen S Rich; Jørn Nerup
Genetics of type 1 diabetes: what's next?
Diabetes 2010;59(7):1561-71.
2009: S S Rich; B Akolkar; Patrick Concannon; Henry A Erlich; Joan E Hilner; C Julier; Grant Morahan; Jørn Nerup; C Nierras; Flemming Pociot; John A Todd
Current status and the future for the genetics of type I diabetes.
Genes and immunity 2009;10 Suppl 1():S128-31.
2009: S S Rich; B Akolkar; Patrick Concannon; Henry A Erlich; Joan E Hilner; C Julier; Grant Morahan; Jørn Nerup; C Nierras; Flemming Pociot; John A Todd
Overview of the Type I Diabetes Genetics Consortium.
Genes and immunity 2009;10 Suppl 1():S1-4.
2009: Rikke Borg; Jørn Nerup; David M Nathan; Judith Kuenen; Hui Zheng; David Schoenfeld; Robert J Heine
[Glycated haemoglobin may in future be reported as estimated mean blood glucose concentration--secondary publication].
Ugeskrift for laeger 2009;171(45):3262-5.
2009: Jeffrey C Barrett; David G Clayton; Patrick Concannon; Beena Akolkar; Jason D Cooper; Henry A Erlich; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion Nierras; Vincent Plagnol; Flemming Pociot; Helen Schuilenburg; Deborah J Smyth; Helen Stevens; John A Todd; Neil M Walker; Stephen S Rich
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Nature genetics 2009;41(6):703-7.
2009: Patrick Concannon; Wei-Min Chen; Cécile Julier; Grant Morahan; Beena Akolkar; Henry A Erlich; Joan E Hilner; Jørn Nerup; Concepcion Nierras; Flemming Pociot; John A Todd; Stephen S Rich
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.
Diabetes 2009;58(4):1018-22.
2009: T Gylvin; Jakob Ek; Runa Louise Nolsoe; Anders Albrechtsen; Gitte Andersen; Regine Bergholdt; C Brorsson; C H Bang-Berthelsen; Torben Hansen; Allan E Karlsen; Nils Billestrup; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Functional SOCS1 polymorphisms are associated with variation in obesity in whites.
Diabetes, obesity & metabolism 2009;11(3):196-203.
2009: S S Rich; B Akolkar; P Concannon; Henry A Erlich; Joan E Hilner; C Julier; Grant Morahan; Jørn Nerup; C Nierras; Flemming Pociot; John A Todd
Results of the MHC fine mapping workshop.
Diabetes, obesity & metabolism 2009;11 Suppl 1():108-9.
2008: Patrick Concannon; Suna Onengut-Gumuscu; John A Todd; Deborah J Smyth; Flemming Pociot; Regine Bergholdt; Beena Akolkar; Henry A Erlich; Joan E Hilner; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion R Nierras; Wei-Min Chen; Stephen S Rich
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.
Diabetes 2008;57(10):2858-61.
2008: Brigitte Reusens; Thomas Sparre; L Kalbe; T Bouckenooghe; N Theys; M Kruhøffer; Torben F Orntoft; Jørn Nerup; Claude Remacle
The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation.
Diabetologia 2008;51(5):836-45.
2008: Jesper Johannesen; Stefanie Eising; Susanne Kohlwes; Susanne Riis; Maiken Beck; Bendix Carstensen; Inger Bendtson; Jørn Nerup
Treatment of Danish adolescent diabetic patients with CSII - a matched study to MDI.
Pediatric diabetes 2008;9(1):23-8.
2008: Ana M Wägner; Paul Cloos; Regine Bergholdt; Stefanie Eising; Caroline Brorsson; Martin Stahlhut; Stephan Christgau; Jørn Nerup; Flemming Pociot
Posttranslational Protein Modifications in Type 1 Diabetes - Genetic Studies with PCMT1, the Repair Enzyme Protein Isoaspartate Methyltransferase (PIMT) Encoding Gene.
The review of diabetic studies : RDS 2008;5(4):225-31.
2007: Stefanie Eising; Jannet Svensson; Kristin Skogstrand; Anita Nilsson; Kristian Lynch; Paal Skytt Andersen; Ake Lernmark; David M Hougaard; Flemming Pociot; Bent Nørgaard-Pedersen; Jørn Nerup
Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study.
Paediatric and perinatal epidemiology 2007;21(6):507-17.
2007: Benedicte Lie; Marte K Viken; Hanne E Akselsen; Siri T Flåm; Flemming Pociot; Jørn Nerup; Ingrid Kockum; Anne Cambon-Thomsen; Erik Thorsby; DAG UNDLIEN
Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease.
Human immunology 2007;68(7):592-8.
2007: Regine Bergholdt; Allan E Karlsen; P H Hagedorn; M Aalund; Jens H Nielsen; Mogens Kruhøffer; T Orntoft; H Wang; C B Wollheim; Jørn Nerup; Flemming Pociot
Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets.
Genes and immunity 2007;8(3):232-8.
2007: A M Wägner; Paul Cloos; Regine Bergholdt; Patrice Boissy; Thomas L Andersen; Dennis B Henriksen; C Christiansen; Stephan Christgau; Flemming Pociot; Jørn Nerup
Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase?
Diabetologia 2007;50(3):676-81.
2007: Regine Bergholdt; Zenia M Størling; Kasper Lage; E Olof Karlberg; Páll I Olason; Mogens Aalund; Jørn Nerup; Søren Brunak; Christopher T Workman; Flemming Pociot
Integrative analysis for finding genes and networks involved in diabetes and other complex diseases.
Genome biology 2007;8(11):R253.
2006: K V Skovhus; Regine Bergholdt; C Erichsen; Thomas Sparre; Jørn Nerup; Allan E Karlsen; Flemming Pociot
Identification and characterization of secretagogin promoter activity.
Scandinavian journal of immunology 2006;64(6):639-45.
2006: Ulla Bjerre Christensen; Peter Mose Larsen; Stephen Fey; Allan E Karlsen; Flemming Pociot; Jørn Nerup; Thomas Sparre
Different islet protein expression profiles during spontaneous diabetes development vs. allograft rejection in BB-DP rats.
Autoimmunity 2006;39(4):315-21.
2006: Regine Bergholdt; Stefanie Eising; Jørn Nerup; Flemming Pociot
Increased prevalence of Down's syndrome in individuals with type 1 diabetes in Denmark: A nationwide population-based study.
Diabetologia 2006;49(6):1179-82.
2006: Allan E Karlsen; Zenia M Størling; Thomas Sparre; Martin R Larsen; Amer Mahmood; Joachim Størling; Peter Roepstorff; Krzysztof Wrzesinski; Peter Mose Larsen; Stephen Fey; Karin Nielsen; Peter E Heding; Camillo Ricordi; Jesper Johannesen; Ole P Kristiansen; Ulla Bjerre Christensen; Ingrid Kockum; Holger Luthman; Jørn Nerup; Flemming Pociot
Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3.
Biochemical and biophysical research communications 2006;344(1):406-15.
2006: Anne Blomhoff; M Olsson; S Johansson; Hanne E Akselsen; Flemming Pociot; Jørn Nerup; Ingrid Kockum; Anne Cambon-Thomsen; Erik Thorsby; DAG UNDLIEN; Benedicte Lie
Linkage disequilibrium and haplotype blocks in the MHC vary in an HLA haplotype specific manner assessed mainly by DRB1*03 and DRB1*04 haplotypes.
Genes and immunity 2006;7(2):130-40.
2006: Philippe A Halban; Ele Ferrannini; Jørn Nerup
Diabetes research investment in the European Union.
Nature medicine 2006;12(1):70-2.
2006: Anders Johansen; Dorit P Jensen; Regine Bergholdt; H B Mortensen; Flemming Pociot; Jørn Nerup; Torben Hansen; Oluf Pedersen
IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?
Diabetes, obesity & metabolism 2006;8(1):75-82.
2005: Patrick Concannon; Henry A Erlich; Cécile Julier; Grant Morahan; Jørn Nerup; Flemming Pociot; John A Todd; Stephen S Rich
Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families.
Diabetes 2005;54(10):2995-3001.
2005: T Gylvin; Regine Bergholdt; Jørn Nerup; Flemming Pociot
To: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900-905.
Diabetologia 2005;48(10):2183-4.
2005: Thomas Sparre; A M Ejrnaes Sprinkel; U Bjerre Christensen; Allan E Karlsen; Flemming Pociot; Jørn Nerup
Anaesthesia-induced hyperglycaemia early in life is not predictive for development of diabetes in diabetes-prone BB rats.
Acta diabetologica 2005;42(2):95-8.
2005: Regine Bergholdt; Camilla Taxvig; Stefanie Eising; Jørn Nerup; Flemming Pociot
CBLB variants in type 1 diabetes and their genetic interaction with CTLA4.
Journal of leukocyte biology 2005;77(4):579-85.
2005: L Kalbe; A Leunda; Thomas Sparre; C Meulemans; Marie-Thérèse Ahn; Torben F Orntoft; Mogens Kruhoffer; Brigitte Reusens; Jørn Nerup; Claude Remacle
Nutritional regulation of proteases involved in fetal rat insulin secretion and islet cell proliferation.
The British journal of nutrition 2005;93(3):309-16.
2005: Regine Bergholdt; Jørn Nerup; Flemming Pociot
Fine mapping of a region on chromosome 21q21.11-q22.3 showing linkage to type 1 diabetes.
Journal of medical genetics 2005;42(1):17-25.
2004: K Nielsen; Mogens Kruhøffer; T Orntoft; Thomas Sparre; H Wang; C Wollheim; M C Jørgensen; Jørn Nerup; Allan E Karlsen
Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity.
Diabetologia 2004;47(12):2185-99.
2004: Allan E Karlsen; Peter E Heding; H Frobøse; Sif G Rønn; Mogens Kruhøffer; T F Orntoft; Martine I Darville; Decio L Eizirik; Flemming Pociot; Jørn Nerup; Thomas Mandrup-Poulsen; Nils Billestrup
Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Diabetologia 2004;47(11):1998-2011.
2004: Jesper Johannesen; Angeles Pie; Allan E Karlsen; Zenia Marian Larsen; Allan Jensen; Henrik Vissing; Ole P Kristiansen; Flemming Pociot; Jørn Nerup
Is mortalin a candidate gene for T1DM ?
Autoimmunity 2004;37(6-7):423-30.
2004: T Gylvin; Runa Louise Nolsoe; Torben Hansen; E M D Nielsen; Regine Bergholdt; Allan E Karlsen; Nils Billestrup; Knut Borch-Johnsen; Oluf Pedersen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.
Diabetologia 2004;47(7):1273-7.
2004: Thomas Sparre; Ulla Bjerre Christensen; C F Gotfredsen; Peter Mose Larsen; Stephen Fey; K Hjernø; Peter Roepstorff; Flemming Pociot; Allan E Karlsen; Jørn Nerup
Changes in expression of IL-1 beta influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats.
Diabetologia 2004;47(5):892-908.
2004: Regine Bergholdt; Pegah Ghandil; Jesper Johannesen; Ole P Kristiansen; Ingrid Kockum; H Luthman; Kjersti S Rønningen; Jørn Nerup; Cécile Julier; Flemming Pociot
Genetic and functional evaluation of an interleukin-12 polymorphism (IDDM18) in families with type 1 diabetes.
Journal of medical genetics 2004;41(4):e39.
2004: Flemming Pociot; Allan E Karlsen; Claus B Pedersen; Mogens Aalund; Jørn Nerup
Novel analytical methods applied to type 1 diabetes genome-scan data.
American journal of human genetics 2004;74(4):647-60.
2004: Zenia Marian Larsen; Jesper Johannesen; Ole P Kristiansen; Jørn Nerup; Flemming Pociot
Evidence for linkage on chromosome 4p16.1 in Type 1 diabetes Danish families and complete mutation scanning of the WFS1 (Wolframin) gene.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(3):218-22.
2004: Regine Bergholdt; Peter E Heding; Karin Nielsen; Runa Louise Nolsoe; Thomas Sparre; Joachim Størling; Jørn Nerup; Flemming Pociot; Thomas Mandrup-Poulsen
Type 1 database mellitus: an inflammatory disease of the islet.
Advances in experimental medicine and biology 2004;552():129-53.
2004: K Nielsen; Thomas Sparre; Martin R Larsen; M Nielsen; Stephen Fey; P Mose Larsen; Peter Roepstorff; Jørn Nerup; Allan E Karlsen
Protein expression changes in a cell system of beta-cell maturation reflect an acquired sensitivity to IL-1beta.
Diabetologia 2004;47(1):62-74.
2003: Thomas Sparre; Regine Bergholdt; Jørn Nerup; Flemming Pociot
Application of genomics and proteomics in Type 1 diabetes pathogenesis research.
Expert review of molecular diagnostics 2003;3(6):743-57.
2003: Thomas Sparre; Brigitte Reusens; H Cherif; Martin R Larsen; Peter Roepstorff; Stephen Fey; P Mose Larsen; Claude Remacle; Jørn Nerup
Intrauterine programming of fetal islet gene expression in rats--effects of maternal protein restriction during gestation revealed by proteome analysis.
Diabetologia 2003;46(11):1497-511.
2003: Stefan Johansson; Benedicte Lie; Anne Cambon-Thomsen; Flemming Pociot; Jørn Nerup; Ingrid Kockum; Erik Thorsby; DAG UNDLIEN
No evidence of type 1 diabetes susceptibility genes in the region centromeric of the HLA complex.
Human immunology 2003;64(10):951-9.
2003: Jesper Johannesen; Allan E Karlsen; Flemming Pociot; Sif G Roenn; Jørn Nerup
Strain dependent rat iNOS promoter activity--correlation to identified WT1 transcription factor binding site.
Autoimmunity 2003;36(3):167-75.
2003: S Johansson; Benedicte Lie; Flemming Pociot; Jørn Nerup; Anne Cambon-Thomsen; Ingrid Kockum; Erik Thorsby; DAG UNDLIEN
HLA associations in type 1 diabetes: DPB1 alleles may act as markers of other HLA-complex susceptibility genes.
Tissue antigens 2003;61(5):344-51.
2003: Thomas Sparre; Anne M Ejrnaes Sprinkel; Ulla Bjerre Christensen; Allan E Karlsen; Flemming Pociot; Jørn Nerup
Prophylactic insulin treatment of syngeneically transplanted pre-diabetic BB-DP rats.
Autoimmunity 2003;36(2):99-109.
2003: S Johansson; Benedicte Lie; J A Todd; Flemming Pociot; Jørn Nerup; Anne Cambon-Thomsen; Ingrid Kockum; Hanne E Akselsen; Erik Thorsby; DAG UNDLIEN
Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and -DRB1.
Genes and immunity 2003;4(1):46-53.
2002: Jannet Svensson; Bendix Carstensen; AnneGrete Mølbak; Bjørn Christau; Henrik B Mortensen; Jørn Nerup; Knut Borch-Johnsen
Increased risk of childhood type 1 diabetes in children born after 1985.
Diabetes care 2002;25(12):2197-201.
2002: Thomas Sparre; Ulla Bjerre Christensen; P Mose Larsen; Stephen Fey; Krzysztof Wrzesinski; Peter Roepstorff; Thomas Mandrup-Poulsen; Flemming Pociot; Allan E Karlsen; Jørn Nerup
IL-1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis.
Diabetologia 2002;45(11):1550-61.
2002: T Gylvin; Regine Bergholdt; Jørn Nerup; Flemming Pociot
Characterization of a nuclear-factor-kappa B (NFkappaB) genetic marker in type 1 diabetes (T1DM) families.
Genes and immunity 2002;3(7):430-2.
2002: L Leigh Field; Zenia Marian Larsen; Flemming Pociot; Jørn Nerup; Rose Tobias; Vagn Bonnevie-Nielsen
Evidence for a locus (IDDM16) in the immunoglobulin heavy chain region on chromosome 14q32.3 producing susceptibility to type 1 diabetes.
Genes and immunity 2002;3(6):338-44.
2001: Zenia Marian Larsen; Anna D'Angelo; M Cattaneo; Jørn Nerup; Ida Biunno; Massimo Zollo; Flemming Pociot
Complete mutation scanning of the human SEL 1L gene: a candidate gene for type 1 diabetes.
Acta diabetologica 2001;38(4):191-2.
2001: Peter E Heding; Allan E Karlsen; Riitta Veijola; Jørn Nerup; Flemming Pociot
No evidence of a functionally significant polymorphism of the BCL2 gene in Danish, Finnish and Basque type 1 diabetes families.
Genes and immunity 2001;2(7):398-400.
2001: Allan E Karlsen; Sif G Rønn; Karen Lindberg; Jesper Johannesen; Elisabeth D Galsgaard; Flemming Pociot; Jens H Nielsen; Thomas Mandrup-Poulsen; Jørn Nerup; Nils Billestrup
Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12191-6.
2001: Claude Remacle; Brigitte Reusens; L Kalbe; C N Hales; Susan E Ozanne; Bernadette Bréant; M Polak; William D Rees; Caroline McKinnon; S F Olsen; Jørn Nerup; J Tamarit; Wolf Reik
Early malnutrition and programming of adult degenerative diseases: experimental, epidemiological and preventive studies.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2001;11(4 Suppl):99-102.
2001: Jesper Johannesen; Flemming Pociot; Allan E Karlsen; Thomas Mandrup-Poulsen; Jørn Nerup
Strain-dependent difference in inducible nitric oxide synthesis (iNOS) expression in rat pancreatic islets correlates with interferon regulating factor 1 (IRF-1) and heat shock protein 70 (HSP70) expression.
European cytokine network 2001;12(3):501-9.
2001: Flemming Pociot; Zenia Marian Larsen; Patrizia Zavattari; Elisabetta Deidda; Jørn Nerup; M Cattaneo; Raffaella Chiaramonte; Paola Comi; M Sabbadini; Massimo Zollo; Ida Biunno; Francesco Cucca
No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility.
Diabetes/metabolism research and reviews 2001;17(4):292-5.
2001: Jesper Johannesen; A Pie; Flemming Pociot; Ole P Kristiansen; Allan E Karlsen; Jørn Nerup
Linkage of the human inducible nitric oxide synthase gene to type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2001;86(6):2792-6.
2001: Peter Mose Larsen; Stephen Fey; Martin R Larsen; Artur Nawrocki; HU Andersen; H Kähler; C Heilmann; M C Voss; Peter Roepstorff; Flemming Pociot; Allan E Karlsen; Jørn Nerup
Proteome analysis of interleukin-1beta--induced changes in protein expression in rat islets of Langerhans.
Diabetes 2001;50(5):1056-63.
2001: Allan E Karlsen; Thomas Sparre; K Nielsen; Jørn Nerup; Flemming Pociot
Proteome analysis--a novel approach to understand the pathogenesis of Type 1 diabetes mellitus.
Disease markers 2001;17(4):205-16.
2000: Regine Bergholdt; Zenia Marian Larsen; NA Andersen; Jesper Johannesen; Ole P Kristiansen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Characterization of new polymorphisms in the 5' UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level.
Genes and immunity 2000;1(8):495-500.
2000: Ole P Kristiansen; Runa Louise Nolsoe; H Holst; Sine Reker Hadrup; Zenia Marian Larsen; Jesper Johannesen; Jørn Nerup; Flemming Pociot; Thomas Mandrup-Poulsen
The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes.
Immunogenetics 2000;52(1-2):107-11.
2000: NE John; HU Andersen; Stephen Fey; Peter Mose Larsen; Peter Roepstorff; Martin R Larsen; Flemming Pociot; Allan E Karlsen; Jørn Nerup; Irene C Green; Thomas Mandrup-Poulsen
Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.
Diabetes 2000;49(11):1819-29.
2000: Jesper Johannesen; Flemming Pociot; Ole P Kristiansen; Allan E Karlsen; Jørn Nerup
No evidence for linkage in the promoter region of the inducible nitric oxide synthase gene (NOS2) in a Danish type 1 diabetes population.
Genes and immunity 2000;1(6):362-6.
2000: Runa Louise Nolsoe; Ole P Kristiansen; K Sangthongpitag; Zenia Marian Larsen; Jesper Johannesen; Allan E Karlsen; Flemming Pociot; Jørn Nerup; CF Verge; Thomas Mandrup-Poulsen
Complete molecular scanning of the human Fas gene: mutational analysis and linkage studies in families with type I diabetes mellitus. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
Diabetologia 2000;43(6):800-8.
2000: Ole P Kristiansen; Flemming Pociot; E P Bennett; H Clausen; Jesper Johannesen; Jørn Nerup; Thomas Mandrup-Poulsen
IDDM7 links to insulin-dependent diabetes mellitus in Danish multiplex families but linkage is not explained by novel polymorphisms in the candidate gene GALNT3. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
Human mutation 2000;15(3):295-6.
2000: Allan E Karlsen; D Pavlovic; K Nielsen; J Jensen; HU Andersen; Flemming Pociot; Thomas Mandrup-Poulsen; Decio L Eizirik; Jørn Nerup
Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism.
The Journal of clinical endocrinology and metabolism 2000;85(2):830-6.
2000: Ole P Kristiansen; Flemming Pociot; Jesper Johannesen; Regine Bergholdt; C A Dinarello; Jørn Nerup; Thomas Mandrup-Poulsen
Linkage disequilibrium testing of four interleukin-1 gene-cluster polymorphisms in Danish multiplex families with insulin-dependent diabetes mellitus.
Cytokine 2000;12(2):171-5.
2000: Ulla Bjerre Christensen; Peter Mose Larsen; Stephen Fey; HU Andersen; Artur Nawrocki; Thomas Sparre; Thomas Mandrup-Poulsen; Jørn Nerup
Islet protein expression changes during diabetes development in islet syngrafts in BB-DP rats and during rejection of BB-DP islet allografts.
Autoimmunity 2000;32(1):1-15.
1999: K Nielsen; Allan E Karlsen; M Deckert; O D Madsen; Palle Serup; Thomas Mandrup-Poulsen; Jørn Nerup
Beta-cell maturation leads to in vitro sensitivity to cytotoxins.
Diabetes 1999;48(12):2324-32.
1999: T O'Brien; Allan E Karlsen; HU Andersen; Thomas Mandrup-Poulsen; Jørn Nerup
Absence of toxicity associated with adenoviral-mediated transfer of the beta-galactosidase reporter gene to neonatal rat islets in vitro.
Diabetes research and clinical practice 1999;44(3):157-63.
1999: T Lorenzen; Flemming Pociot; Jesper Johannesen; Ole P Kristiansen; Jørn Nerup
A population-based survey of frequencies of self-reported spontaneous and induced abortions in Danish women with Type 1 diabetes mellitus. Danish IDDM Epidemiology and Genetics Group.
Diabetic medicine : a journal of the British Diabetic Association 1999;16(6):472-6.
1999: Hans-Henrik Parving; Lise Tarnow; Flemming S Nielsen; Peter Rossing; Thomas Mandrup-Poulsen; R Osterby; Jørn Nerup
Cyclosporine nephrotoxicity in type 1 diabetic patients. A 7-year follow-up study.
Diabetes care 1999;22(3):478-83.
1999: Benedicte Lie; J A Todd; Flemming Pociot; Jørn Nerup; Hanne E Akselsen; Geir Joner; Knut Dahl-Jørgensen; Kjersti S Rønningen; Erik Thorsby; DAG UNDLIEN
The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene.
American journal of human genetics 1999;64(3):793-800.
1999: Zenia Marian Larsen; Ole P Kristiansen; E Mato; Jesper Johannesen; M Puig-Domingo; Alberto de Leiva; Jørn Nerup; Flemming Pociot
IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34 in genetic susceptibility to type 1 diabetes (insulin-dependent).
Autoimmunity 1999;31(1):35-42.
1999: Ole P Kristiansen; Zenia Marian Larsen; Jesper Johannesen; Jørn Nerup; Thomas Mandrup-Poulsen; Flemming Pociot
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
Human mutation 1999;14(1):67-70.
1998: AM Møller; Louise Torp Dalgaard; Flemming Pociot; Jørn Nerup; Torben Hansen; Oluf Pedersen
Mutations in the hepatocyte nuclear factor-1alpha gene in Caucasian families originally classified as having Type I diabetes.
Diabetologia 1998;41(12):1528-31.
1998: Flemming Pociot; PM Hansen; Allan E Karlsen; B L Langdahl; Jesper Johannesen; Jørn Nerup
TGF-beta1 gene mutations in insulin-dependent diabetes mellitus and diabetic nephropathy.
Journal of the American Society of Nephrology : JASN 1998;9(12):2302-7.
1998: L Esposito; N J Hill; L E Pritchard; Francesco Cucca; CE Muxworthy; Marilyn E Merriman; A Wilson; Cécile Julier; M Delepine; Jaakko Tuomilehto; Eva Tuomilehto-Wolf; C Ionesco-Tirgoviste; L Nistico'; Raffaella Buzzetti; Paolo Pozzilli; M Ferrari; Emanuele Bosi; Flemming Pociot; Jørn Nerup; SC Bain; John A Todd
Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group.
Diabetes 1998;47(11):1797-9.
1998: Y Nakagawa; Y Kawaguchi; Rebecca C J Twells; CE Muxworthy; Kara M Hunter; A Wilson; Marilyn E Merriman; Roger D Cox; Tony R Merriman; Francesco Cucca; PA McKinney; Julian P H Shield; Jaakko Tuomilehto; Eva Tuomilehto-Wolf; C Ionesco-Tirgoviste; Lorenza Nisticò; R Buzzetti; Paolo Pozzilli; Geir Joner; Erik Thorsby; DAG UNDLIEN; Flemming Pociot; Jørn Nerup; K S Rönningen; SC Bain; John A Todd
Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13.
American journal of human genetics 1998;63(2):547-56.
1998: E H Duun; B Nygaard; Jørn Nerup
[Thyrotoxicosis at the onset of diabetes mellitus. Report of five cases].
Ugeskrift for laeger 1998;160(29):4327-30.
1998: T Lorenzen; Flemming Pociot; L Stilgren; Ole P Kristiansen; Jesper Johannesen; P B Olsen; A Walmar; A Larsen; N C Albrechtsen; P C Eskildsen; O O Andersen; Jørn Nerup
Predictors of IDDM recurrence risk in offspring of Danish IDDM patients. Danish IDDM Epidemiology and Genetics Group.
Diabetologia 1998;41(6):666-73.
1998: Tony R Merriman; Iain A Eaves; Rebecca C J Twells; Marilyn E Merriman; Patrick Danoy; CE Muxworthy; Kara M Hunter; Roger D Cox; Francesco Cucca; PA McKinney; Julian P H Shield; JD Baum; Jaakko Tuomilehto; Eva Tuomilehto-Wolf; C Ionesco-Tirgoviste; Geir Joner; Erik Thorsby; DAG UNDLIEN; Flemming Pociot; Jørn Nerup; Kjersti S Ronningen; SC Bain; John A Todd
Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6).
Human molecular genetics 1998;7(3):517-24.
1998: Ole P Kristiansen; M Zamani; Jesper Johannesen; Thomas Mandrup-Poulsen; J J Cassiman; Jørn Nerup; Flemming Pociot
Linkage and association between a CD4 gene polymorphism and IDDM in Danish IDDM patients. The Danish IDDM Epidemiology and Genetics Group, and The Danish Study Group of Diabetes in Childhood.
Diabetes 1998;47(2):281-3.
1998: Ulla Bjerre Christensen; Thomas Sparre; A Cooke; HU Andersen; Thomas Mandrup-Poulsen; Jørn Nerup
Syngeneic islet transplantation in prediabetic BB-DP rats--a synchronized model for studying beta-cell destruction during the development of IDDM.
Autoimmunity 1998;28(2):91-107.
1997: Simon T Bennett; AJ Wilson; L Esposito; N Bouzekri; DAG UNDLIEN; Francesco Cucca; Lorenza Nisticò; R Buzzetti; E Bosi; Flemming Pociot; Jørn Nerup; Anne Cambon-Thomsen; Alberto Pugliese; Julian P H Shield; PA McKinney; SC Bain; Constantin Polychronakos; John A Todd
Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.
Nature genetics 1997;17(3):350-2.
1997: Jesper Johannesen; Allan E Karlsen; Jørn Nerup; Flemming Pociot
No association or linkage to IDDM of an interferon regulatory factor-1 gene polymorphism in a Danish population. The Danish Study Group for Diabetes in Childhood.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 1997;24(5):377-83.
1997: HU Andersen; Stephen Fey; Peter Mose Larsen; Artur Nawrocki; K R Hejnaes; Thomas Mandrup-Poulsen; Jørn Nerup
Interleukin-1beta induced changes in the protein expression of rat islets: a computerized database.
Electrophoresis 1997;18(11):2091-103.
1997: D Mauricio; HU Andersen; Claus Morten Larsen; Allan E Karlsen; Thomas Mandrup-Poulsen; Jørn Nerup
Dexamethasone prevents interleukin-1beta-mediated inhibition of rat islet insulin secretion without decreasing nitric oxide production.
Cytokine 1997;9(8):563-9.
1997: Tony R Merriman; Rebecca C J Twells; Marilyn E Merriman; Iain A Eaves; R Cox; Francesco Cucca; Patricia McKinney; Julian P H Shield; D Baum; E Bosi; P Pozzilli; Lorenza Nisticò; Raffaella Buzzetti; Geir Joner; K S Rønningen; K Rønningen; Erik Thorsby; DAG UNDLIEN; Flemming Pociot; Jørn Nerup; S Bain; A Barnett; J Todd
Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21.
Human molecular genetics 1997;6(7):1003-10.
1997: Flemming Pociot; Riitta Veijola; Jesper Johannesen; PM Hansen; T Lorenzen; Allan E Karlsen; Helena Reijonen; Mikael Knip; Jørn Nerup
Analysis of an interferon-gamma gene (IFNG) polymorphism in Danish and Finnish insulin-dependent diabetes mellitus (IDDM) patients and control subjects. Danish Study Group of Diabetes in Childhood.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997;17(2):87-93.
1997: Marc Delépine; Flemming Pociot; C Habita; L Hashimoto; philippe froguel; J Rotter; A Cambon-Thomsen; I Deschamps; S Djoulah; J Weissenbach; Jørn Nerup; Mark Lathrop; Cécile Julier
Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6.
American journal of human genetics 1997;60(1):174-87.
1996: M Zamani; Flemming Pociot; M Spaepen; Petra Raeymaekers; Jørn Nerup; Jean-Jacques Cassiman
Linkage and association of the HLA gene complex with IDDM in 81 Danish families: strong linkage between DR beta 1Lys71+ and IDDM.
Journal of medical genetics 1996;33(11):899-905.
1996: K A Metcalfe; Graham A Hitman; Flemming Pociot; R Bergholdt; Eva Tuomilehto-Wolf; J Tuomilehto; M Viswanathan; A Ramachandran; Jørn Nerup
An association between type 1 diabetes and the interleukin-1 receptor type 1 gene. The DiMe Study Group. Childhood Diabetes in Finland.
Human immunology 1996;51(1):41-8.
1996: S L Thorsteinsson; A Hansen; B Thorsteinsson; Jørn Nerup; Christian Koch
[Glucose tolerance in patients with cystic fibrosis].
Ugeskrift for laeger 1996;158(44):6269-73.
1996: J I Reimers; A K Rasmussen; Allan E Karlsen; U Bjerre; H Liang; O Morin; HU Andersen; Thomas Mandrup-Poulsen; A G Burger; U Feldt-Rasmussen; Jørn Nerup
Interleukin-1 beta inhibits rat thyroid cell function in vivo and in vitro by an NO-independent mechanism and induces hypothyroidism and accelerated thyroiditis in diabetes-prone BB rats.
The Journal of endocrinology 1996;151(1):147-57.
1996: M Zamani; Flemming Pociot; Petra Raeymaekers; Jørn Nerup; Jean-Jacques Cassiman
Linkage of type I diabetes to 15q26 (IDDM3) in the Danish population.
Human genetics 1996;98(4):491-6.
1996: Simon T Bennett; AJ Wilson; Francesco Cucca; Jørn Nerup; Flemming Pociot; P A McKinney; A H Barnett; S C Bain; John A Todd
IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.
Journal of autoimmunity 1996;9(3):415-21.
1996: J I Reimers; HU Andersen; D Mauricio; Flemming Pociot; Allan E Karlsen; J S Petersen; Thomas Mandrup-Poulsen; Jørn Nerup
Strain-dependent differences in sensitivity of rat beta-cells to interleukin 1 beta in vitro and in vivo: association with islet nitric oxide synthesis.
Diabetes 1996;45(6):771-8.
1996: D Mauricio; Thomas Mandrup-Poulsen; Jørn Nerup
Vitamin D analogues in insulin-dependent diabetes mellitus and other autoimmune diseases: a therapeutic perspective.
Diabetes/metabolism reviews 1996;12(1):57-68.
1996: HU Andersen; D Mauricio; Allan E Karlsen; Thomas Mandrup-Poulsen; J H Nielsen; Jørn Nerup
Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(2):251-9.
1996: U B Christensen; D Mauricio; J I Reimers; HU Andersen; T Kalland; Jørn Nerup; Thomas Mandrup-Poulsen
Linomide increases plasma corticosterone in normal rats, but does not prevent the inhibitory action of IL-1 on beta-cells in vivo or ex vivo.
Autoimmunity 1996;23(4):257-68.
1996: Thomas Mandrup-Poulsen; Jørn Nerup; J I Reimers; Flemming Pociot; HU Andersen; Allan E Karlsen; U Bjerre; R Bergholdt
Cytokines and the endocrine system. II. Roles in substrate metabolism, modulation of thyroidal and pancreatic endocrine cell functions and autoimmune endocrine diseases.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(1):21-30.
1995: Thomas Mandrup-Poulsen; Jørn Nerup; J I Reimers; Flemming Pociot; HU Andersen; Allan E Karlsen; U Bjerre; R Bergholdt
Cytokines and the endocrine system. I. The immunoendocrine network.
European journal of endocrinology / European Federation of Endocrine Societies 1995;133(6):660-71.
1995: R Bergholdt; Allan E Karlsen; Jesper Johannesen; PM Hansen; C A Dinarello; Jørn Nerup; Flemming Pociot
Characterization of polymorphisms of an interleukin 1 receptor type 1 gene (IL1RI) promotor region (P2) and their relation to insulin-dependent diabetes mellitus (IDDM). The Danish Study Group of Diabetes in Childhood.
Cytokine 1995;7(7):727-33.
1995: Susanne Lanng; A Hansen; B Thorsteinsson; Jørn Nerup; Christian Koch
Glucose tolerance in patients with cystic fibrosis: five year prospective study.
BMJ (Clinical research ed.) 1995;311(7006):655-9.
1995: HU Andersen; Peter Mose Larsen; Stephen Fey; Allan E Karlsen; Thomas Mandrup-Poulsen; Jørn Nerup
Two-dimensional gel electrophoresis of rat islet proteins. Interleukin 1 beta-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide.
Diabetes 1995;44(4):400-7.
1995: Thomas Mandrup-Poulsen; L D Wogensen; M Jensen; P Svensson; P Nilsson; T Emdal; J Mølvig; C A Dinarello; Jørn Nerup
Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury.
Critical care medicine 1995;23(1):26-33.
1994: JS Petersen; Thomas Dyrberg; Allan E Karlsen; J Mølvig; Birgitte K Michelsen; Jørn Nerup; Thomas Mandrup-Poulsen
Glutamic acid decarboxylase (GAD65) autoantibodies in prediction of beta-cell function and remission in recent-onset IDDM after cyclosporin treatment. The Canadian-European Randomized Control Trial Group.
Diabetes 1994;43(11):1291-6.
1994: Thomas Mandrup-Poulsen; Flemming Pociot; J Mølvig; L Shapiro; P Nilsson; T Emdal; ME Røder; L L Kjems; C A Dinarello; Jørn Nerup
Monokine antagonism is reduced in patients with IDDM.
Diabetes 1994;43(10):1242-7.
1994: Jørn Nerup; Thomas Mandrup-Poulsen; S Helqvist; HU Andersen; Flemming Pociot; J I Reimers; B G Cuartero; Allan E Karlsen; U Bjerre; T Lorenzen
On the pathogenesis of IDDM.
Diabetologia 1994;37 Suppl 2():S82-9.
1994: J I Reimers; U Bjerre; Thomas Mandrup-Poulsen; Jørn Nerup
Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases.
Cytokine 1994;6(5):512-20.
1994: K Nørgaard; Flemming Pociot; N Hobolth; O Andersen; Jørn Nerup
[Familial aggregation of insulin-dependent diabetes mellitus in Denmark. A nation-wide population study].
Ugeskrift for laeger 1994;156(33):4710-3.
1994: Susanne Lanng; B Thorsteinsson; Jørn Nerup; Christian Koch
Diabetes mellitus in cystic fibrosis: effect of insulin therapy on lung function and infections.
Acta paediatrica (Oslo, Norway : 1992) 1994;83(8):849-53.
1994: Susanne Lanng; B Thorsteinsson; ME Røder; Jørn Nerup; Christian Koch
Insulin sensitivity and insulin clearance in cystic fibrosis patients with normal and diabetic glucose tolerance.
Clinical endocrinology 1994;41(2):217-23.
1994: HU Andersen; K H Jørgensen; J Egeberg; Thomas Mandrup-Poulsen; Jørn Nerup
Nicotinamide prevents interleukin-1 effects on accumulated insulin release and nitric oxide production in rat islets of Langerhans.
Diabetes 1994;43(6):770-7.
1994: I C Gerling; Allan E Karlsen; H D Chapman; HU Andersen; E Boel; J M Cunningham; Jørn Nerup; Edward H Leiter
The inducible nitric oxide synthase gene, Nos2, maps to mouse chromosome 11.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(5):318-20.
1994: T Lorenzen; Flemming Pociot; Philip Hougaard; Jørn Nerup
Long-term risk of IDDM in first-degree relatives of patients with IDDM.
Diabetologia 1994;37(3):321-7.
1994: Susanne Lanng; B Thorsteinsson; C Lund-Andersen; Jørn Nerup; P O Schiøtz; Christian Koch
Diabetes mellitus in Danish cystic fibrosis patients: prevalence and late diabetic complications.
Acta paediatrica (Oslo, Norway : 1992) 1994;83(1):72-7.
1994: J I Reimers; L Mørch; H Markholst; L D Wogensen; HU Andersen; Thomas Mandrup-Poulsen; Jørn Nerup
Interleukin-1 beta (IL-1) does not reduce the diabetes incidence in diabetes-prone BB rats.
Autoimmunity 1994;17(2):105-18.
1994: Flemming Pociot; K S Rønningen; R Bergholdt; T Lorenzen; Jesper Johannesen; K Ye; C A Dinarello; Jørn Nerup
Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes--evidence for polygenicity in man. Danish Study Group of Diabetes in Childhood.
Autoimmunity 1994;19(3):169-78.
1993: Thomas Mandrup-Poulsen; J I Reimers; HU Andersen; Flemming Pociot; Allan E Karlsen; U Bjerre; Jørn Nerup
Nicotinamide treatment in the prevention of insulin-dependent diabetes mellitus.
Diabetes/metabolism reviews 1993;9(4):295-309.
1993: Flemming Pociot; T Lorenzen; Jørn Nerup
A manganese superoxide dismutase (SOD2) gene polymorphism in insulin-dependent diabetes mellitus.
Disease markers 1993;11(5-6):267-74.
1993: Flemming Pociot; A G Wilson; Jørn Nerup; G W Duff
No independent association between a tumor necrosis factor-alpha promotor region polymorphism and insulin-dependent diabetes mellitus.
European journal of immunology 1993;23(11):3050-3.
1993: Flemming Pociot; K S Rønningen; Jørn Nerup
Polymorphic analysis of the human MHC-linked heat shock protein 70 (HSP70-2) and HSP70-Hom genes in insulin-dependent diabetes mellitus (IDDM).
Scandinavian journal of immunology 1993;38(5):491-5.
1993: Flemming Pociot; K Nørgaard; N Hobolth; O Andersen; Jørn Nerup
A nationwide population-based study of the familial aggregation of type 1 (insulin-dependent) diabetes mellitus in Denmark. Danish Study Group of Diabetes in Childhood.
Diabetologia 1993;36(9):870-5.
1993: U Zumsteg; J I Reimers; Flemming Pociot; L Mørch; S Helqvist; M Brendel; Rodolfo Alejandro; Thomas Mandrup-Poulsen; C A Dinarello; Jørn Nerup
Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats.
Diabetologia 1993;36(8):759-66.
1993: L Wogensen; M Jensen; P Svensson; H Worsaae; B Welinder; Jørn Nerup
Pancreatic beta-cell function and interleukin-1 beta in plasma during the acute phase response in patients with major burn injuries.
European journal of clinical investigation 1993;23(5):311-9.
1993: Thomas Mandrup-Poulsen; U Zumsteg; J Reimers; Flemming Pociot; L Mørch; S Helqvist; C A Dinarello; Jørn Nerup
Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic beta-cell destruction in insulin-dependent diabetes mellitus.
Cytokine 1993;5(3):185-91.
1993: Susanne Lanng; B Thorsteinsson; ME Røder; Cathrine Orskov; Jens Juul Holst; Jørn Nerup; Christian Koch
Pancreas and gut hormone responses to oral glucose and intravenous glucagon in cystic fibrosis patients with normal, impaired, and diabetic glucose tolerance.
Acta endocrinologica 1993;128(3):207-14.
1993: Susanne Lanng; B Thorsteinsson; Flemming Pociot; M O Marshall; Hans O Madsen; Marianne Schwartz; Jørn Nerup; Christian Koch
Diabetes mellitus in cystic fibrosis: genetic and immunological markers.
Acta paediatrica (Oslo, Norway : 1992) 1993;82(2):150-4.
1993: Flemming Pociot; L Briant; Victor Jongeneel; J Mölvig; H Worsaae; M Abbal; M Thomsen; Jørn Nerup; Anne Cambon-Thomsen
Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus.
European journal of immunology 1993;23(1):224-31.
1992: Susanne Lanng; B Thorsteinsson; Jørn Nerup; Christian Koch
Influence of the development of diabetes mellitus on clinical status in patients with cystic fibrosis.
European journal of pediatrics 1992;151(9):684-7.
1992: Flemming Pociot; J Mølvig; L Wogensen; H Worsaae; Jørn Nerup
A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro.
European journal of clinical investigation 1992;22(6):396-402.
1992: L D Wogensen; J Reimers; Jørn Nerup; V Kolb-Bachofen; K D Kröncke; T Almdal; Thomas Mandrup-Poulsen
Repetitive in vivo treatment with human recombinant interleukin-1 beta modifies beta-cell function in normal rats.
Diabetologia 1992;35(4):331-9.
1991: J Reimers; L D Wogensen; B Welinder; K R Hejnaes; S S Poulsen; P Nilsson; Jørn Nerup
The pharmacokinetics, distribution and degradation of human recombinant interleukin 1 beta in normal rats.
Scandinavian journal of immunology 1991;34(5):597-610.
1991: Susanne Lanng; B Thorsteinsson; G Erichsen; Jørn Nerup; Christian Koch
Glucose tolerance in cystic fibrosis.
Archives of disease in childhood 1991;66(5):612-6.
1991: L Wogensen; J Reimers; Thomas Mandrup-Poulsen; Jørn Nerup
Repeated intraperitoneal injections of interleukin 1 beta induce glucose intolerance in normal rats.
Acta endocrinologica 1991;124(4):470-8.
1991: S Helqvist; B S Polla; Jesper Johannesen; Jørn Nerup
Heat shock protein induction in rat pancreatic islets by recombinant human interleukin 1 beta.
Diabetologia 1991;34(3):150-6.
1991: Flemming Pociot; J Mølvig; L Wogensen; H Worsaae; H Dalbøge; L Baek; Jørn Nerup
A tumour necrosis factor beta gene polymorphism in relation to monokine secretion and insulin-dependent diabetes mellitus.
Scandinavian journal of immunology 1991;33(1):37-49.
1991: S Helqvist; U W Zumsteg; G A Spinas; J P Palmer; Thomas Mandrup-Poulsen; J Egeberg; Jørn Nerup
Repetitive exposure of pancreatic islets to interleukin-1 beta. An in vitro model of pre-diabetes?
Autoimmunity 1991;10(4):311-8.
1990: Jesper Johannesen; S Helqvist; Jørn Nerup
Not all insulin secretagogues sensitize pancreatic islets to recombinant human interleukin 1 beta.
Acta endocrinologica 1990;123(4):445-52.
1990: J Mølvig; Flemming Pociot; L Baek; H Worsaae; L Dall Wogensen; P Christensen; L Staub-Nielsen; Thomas Mandrup-Poulsen; K Manogue; Jørn Nerup
Monocyte function in IDDM patients and healthy individuals.
Scandinavian journal of immunology 1990;32(3):297-311.
1990: S Helqvist; P N Bouchelouche; Jesper Johannesen; Jørn Nerup
Interleukin 1 beta increases the cytosolic free sodium concentration in isolated rat islets of Langerhans.
Scandinavian journal of immunology 1990;32(1):53-8.
1990: J Mølvig; B Sehested Hansen; H Worsaae; K R Hejnaes; M Helle; H Dalbøge; Jørn Nerup
Comparison of biological and immunological activities of human monocyte-derived interleukin 1 beta and human recombinant interleukin 1 beta.
Scandinavian journal of immunology 1990;31(2):225-35.
1990: L D Wogensen; V Kolb-Bachofen; P Christensen; C A Dinarello; Thomas Mandrup-Poulsen; S Martin; Jørn Nerup
Functional and morphological effects of interleukin-1 beta on the perfused rat pancreas.
Diabetologia 1990;33(1):15-23.
1990: L Wogensen; S Helqvist; Flemming Pociot; Jesper Johannesen; J Reimers; Thomas Mandrup-Poulsen; Jørn Nerup
Intra-peritoneal administration of interleukin-1 beta induces impaired insulin release from the perfused rat pancreas.
Autoimmunity 1990;7(1):1-12.
1990: Thomas Mandrup-Poulsen; S Helqvist; L D Wogensen; J Mølvig; Flemming Pociot; Jesper Johannesen; Jørn Nerup
Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells.
Current topics in microbiology and immunology 1990;164():169-93.
1989: J Mølvig; G Sønderstrup McDevitt; M Thomsen; B Bosmann; C Blangero; C de Preval; L Baek; Jørn Nerup
Characterization of PPD-specific T-cell lines generated in type I (insulin-dependent) diabetic and healthy individuals.
Scandinavian journal of immunology 1989;30(5):615-29.
1989: J P Palmer; S Helqvist; G A Spinas; J Mølvig; Thomas Mandrup-Poulsen; HU Andersen; Jørn Nerup
Interaction of beta-cell activity and IL-1 concentration and exposure time in isolated rat islets of Langerhans.
Diabetes 1989;38(10):1211-6.
1989: S Helqvist; P Bouchelouche; HU Andersen; Jørn Nerup
Modulation of calcium flux influences interleukin 1 beta effects on insulin release from isolated islets of Langerhans.
Acta endocrinologica 1989;121(3):447-55.
1989: S Helqvist; B Sehested Hansen; Jesper Johannesen; H Ullits Andersen; J Hoiriis Nielsen; Jørn Nerup
Interleukin 1 induces new protein formation in isolated rat islets of Langerhans.
Acta endocrinologica 1989;121(1):136-40.
1989: HU Andersen; Thomas Mandrup-Poulsen; J Egeberg; S Helqvist; Jørn Nerup
Genetically determined differences in newborn rat islet sensitivity to interleukin-1 in vitro: no association with the diabetes prone phenotype in the BB-rat.
Acta endocrinologica 1989;120(1):92-8.
1989: A Zerbib; J Mølvig; M Thomsen; helene coppin; Anne Cambon-Thomsen; E Sommer; Jørn Nerup; C De Preval
Restriction fragment length polymorphism of HLA and non-HLA genes in DR3/4 heterozygous Danish insulin-dependent diabetic patients and healthy individuals: reassessment of the influence of alpha DX and insulin-linked polymorphic loci, and new splits of DQw3 haplotypes.
Disease markers 1989;7(1):27-41.
1989: Thomas Mandrup-Poulsen; S Helqvist; J Mølvig; L D Wogensen; Jørn Nerup
Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus.
Autoimmunity 1989;4(3):191-218; discussion 219-34.
1988: Jørn Nerup; Thomas Mandrup-Poulsen; J Mølvig; S Helqvist; L Wogensen; J Egeberg
Mechanisms of pancreatic beta-cell destruction in type I diabetes.
Diabetes care 1988;11 Suppl 1():16-23.
1988: G A Spinas; J P Palmer; Thomas Mandrup-Poulsen; H Andersen; J H Nielsen; Jørn Nerup
The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration.
Acta endocrinologica 1988;119(2):307-11.
1988: J Mølvig; L Baek; P Christensen; K R Manogue; H Vlassara; P Platz; L S Nielsen; A Svejgaard; Jørn Nerup
Endotoxin-stimulated human monocyte secretion of interleukin 1, tumour necrosis factor alpha, and prostaglandin E2 shows stable interindividual differences.
Scandinavian journal of immunology 1988;27(6):705-16.
1988: L D Wogensen; Thomas Mandrup-Poulsen; H Markholst; J Mølvig; A Lernmark; J J Holst; C A Dinarello; Jørn Nerup
Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas.
Acta endocrinologica 1988;117(3):302-6.
1988: M Thomsen; J Mølvig; A Zerbib; C de Preval; Michel Abbal; Jean-Michel Dugoujon; E Ohayon; A Svejgaard; Anne Cambon-Thomsen; Jørn Nerup
The susceptibility to insulin-dependent diabetes mellitus is associated with C4 allotypes independently of the association with HLA-DQ alleles in HLA-DR3,4 heterozygotes.
Immunogenetics 1988;28(5):320-7.
1988: B S Hansen; Jens H Nielsen; S Linde; G A Spinas; B S Welinder; Thomas Mandrup-Poulsen; Jørn Nerup
Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets.
Biomedica biochimica acta 1988;47(4-5):305-9.
1987: T Mandrup-Poulsen; K Bendtzen; C A Dinarello; Jørn Nerup
Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(12):4077-82.
1987: G A Spinas; B S Hansen; S Linde; W Kastern; J Mølvig; Thomas Mandrup-Poulsen; C A Dinarello; Jens H Nielsen; Jørn Nerup
Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans.
Diabetologia 1987;30(7):474-80.
1987: Thomas Mandrup-Poulsen; G A Spinas; Stephen James Prowse; B S Hansen; D W Jørgensen; K Bendtzen; J H Nielsen; Jørn Nerup
Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics.
Diabetes 1987;36(5):641-7.
1987: Thomas Mandrup-Poulsen; J Egeberg; Jørn Nerup; K Bendtzen; J H Nielsen; C A Dinarello
Ultrastructural studies of time-course and cellular specificity of interleukin-1 mediated islet cytotoxicity.
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology 1987;95(2):55-63.
1986: G A Spinas; Thomas Mandrup-Poulsen; J Mølvig; L Baek; K Bendtzen; C A Dinarello; Jørn Nerup
Low concentrations of interleukin-1 stimulate and high concentrations inhibit insulin release from isolated rat islets of Langerhans.
Acta endocrinologica 1986;113(4):551-8.
1986: Thomas Mandrup-Poulsen; K Bendtzen; Jørn Nerup; J Egeberg; J H Nielsen
Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans.
Allergy 1986;41(4):250-9.