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Jørn Nerup

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Linkage Disequilibrium

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TOP 3
Borg Rikke; Nerup Jørn; Nathan David M; Kuenen Judith; Zheng Hui; Schoenfeld David; Heine Robert J;
[Glycated haemoglobin may in future be reported as estimated mean blood glucose concentration--secondary publication]
Concannon Patrick; Chen Wei-Min; Julier Cécile; Morahan Grant; Akolkar Beena; Erlich Henry A; Hilner Joan E; Nerup Jørn; Nierras Concepcion; Pociot Flemming; Todd John A; Rich Stephen S;
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.
Gylvin T; Ek J; Nolsøe R; Albrechtsen A; Andersen G; Bergholdt R; Brorsson C; Bang-Berthelsen C H; Hansen T; Karlsen A E; Billestrup N; Borch-Johnsen K; Jørgensen T; Pedersen O; Mandrup-Poulsen T; Nerup J; Pociot F
Functional SOCS1 polymorphisms are associated with variation in obesity in whites.

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All Publications

2009: Borg Rikke; Nerup Jørn; Nathan David M; Kuenen Judith; Zheng Hui; Schoenfeld David; Heine Robert J;
[Glycated haemoglobin may in future be reported as estimated mean blood glucose concentration--secondary publication]
Ugeskrift for laeger 2009;171(45):3262-5.
2009: Concannon Patrick; Chen Wei-Min; Julier Cécile; Morahan Grant; Akolkar Beena; Erlich Henry A; Hilner Joan E; Nerup Jørn; Nierras Concepcion; Pociot Flemming; Todd John A; Rich Stephen S;
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.
Diabetes 2009;58(4):1018-22.
2009: Gylvin T; Ek J; Nolsøe R; Albrechtsen A; Andersen G; Bergholdt R; Brorsson C; Bang-Berthelsen C H; Hansen T; Karlsen A E; Billestrup N; Borch-Johnsen K; Jørgensen T; Pedersen O; Mandrup-Poulsen T; Nerup J; Pociot F
Functional SOCS1 polymorphisms are associated with variation in obesity in whites.
Diabetes, obesity & metabolism 2009;11(3):196-203.
2009: Rich S S; Akolkar B; Concannon P; Erlich H; Hilner J; Julier C; Morahan G; Nerup J; Nierras C; Pociot F; Todd J A
Results of the MHC fine mapping workshop.
Diabetes, obesity & metabolism 2009;11 Suppl 1():108-9.
2008: Concannon Patrick; Onengut-Gumuscu Suna; Todd John A; Smyth Deborah J; Pociot Flemming; Bergholdt Regine; Akolkar Beena; Erlich Henry A; Hilner Joan E; Julier Cécile; Morahan Grant; Nerup Jørn; Nierras Concepcion R; Chen Wei-Min; Rich Stephen S;
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.
Diabetes 2008;57(10):2858-61.
2008: Reusens B; Sparre T; Kalbe L; Bouckenooghe T; Theys N; Kruhøffer M; Orntoft T F; Nerup J; Remacle C
The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation.
Diabetologia 2008;51(5):836-45.
2008: Johannesen Jesper; Eising Stefanie; Kohlwes Susanne; Riis Susanne; Beck Maiken; Carstensen Bendix; Bendtson Inger; Nerup Jørn
Treatment of Danish adolescent diabetic patients with CSII - a matched study to MDI.
Pediatric diabetes 2008;9(1):23-8.
2008: Wägner Ana M; Cloos Paul; Bergholdt Regine; Eising Stefanie; Brorsson Caroline; Stalhut Martin; Christgau Stephan; Nerup Jørn; Pociot Flemming
Posttranslational Protein Modifications in Type 1 Diabetes - Genetic Studies with PCMT1, the Repair Enzyme Protein Isoaspartate Methyltransferase (PIMT) Encoding Gene.
The review of diabetic studies : RDS 2008;5(4):225-31.
2007: Eising Stefanie; Svensson Jannet; Skogstrand Kristin; Nilsson Anita; Lynch Kristian; Andersen Paal Skytt; Lernmark Ake; Hougaard David M; Pociot Flemming; Nørgaard-Pedersen Bent; Nerup Jørn
Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study.
Paediatric and perinatal epidemiology 2007;21(6):507-17.
2007: Lie Benedicte A; Viken Marte K; Akselsen Hanne E; Flåm Siri T; Pociot Flemming; Nerup Jørn; Kockum Ingrid; Cambon-Thomsen Anne; Thorsby Erik; Undlien Dag E
Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease.
Human immunology 2007;68(7):592-8.
2007: Bergholdt R; Karlsen A E; Hagedorn P H; Aalund M; Nielsen J H; Kruhøffer M; Orntoft T; Wang H; Wollheim C B; Nerup J; Pociot F
Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets.
Genes and immunity 2007;8(3):232-8.
2007: Wägner A M; Cloos P; Bergholdt R; Boissy P; Andersen T L; Henriksen D B; Christiansen C; Christgau S; Pociot F; Nerup J
Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase?
Diabetologia 2007;50(3):676-81.
2007: Bergholdt Regine; Størling Zenia M; Lage Kasper; Karlberg E Olof; Olason Páll I; Aalund Mogens; Nerup Jørn; Brunak Søren; Workman Christopher T; Pociot Flemming
Integrative analysis for finding genes and networks involved in diabetes and other complex diseases.
Genome biology 2007;8(11):R253.
2006: Skovhus K V; Bergholdt R; Erichsen C; Sparre T; Nerup J; Karlsen A E; Pociot F
Identification and characterization of secretagogin promoter activity.
Scandinavian journal of immunology 2006;64(6):639-45.
2006: Christensen Ulla Bjerre; Larsen Peter Mose; Fey Stephen; Karlsen Allan E; Pociot Flemming; Nerup Jørn; Sparre Thomas
Different islet protein expression profiles during spontaneous diabetes development vs. allograft rejection in BB-DP rats.
Autoimmunity 2006;39(4):315-21.
2006: Bergholdt R; Eising S; Nerup J; Pociot F
Increased prevalence of Down's syndrome in individuals with type 1 diabetes in Denmark: A nationwide population-based study.
Diabetologia 2006;49(6):1179-82.
2006: Karlsen Allan E; Størling Zenia M; Sparre Thomas; Larsen Martin R; Mahmood Amer; Størling Joachim; Roepstorff Peter; Wrzesinski Krzysztof; Larsen Peter Mose; Fey Stephen; Nielsen Karin; Heding Peter; Ricordi Camillo; Johannesen Jesper; Kristiansen Ole P; Christensen Ulla B; Kockum Ingrid; Luthman Holger; Nerup Jørn; Pociot Flemming
Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3.
Biochemical and biophysical research communications 2006;344(1):406-15.
2006: Blomhoff A; Olsson M; Johansson S; Akselsen H E; Pociot F; Nerup J; Kockum I; Cambon-Thomsen A; Thorsby E; Undlien D E; Lie B A
Linkage disequilibrium and haplotype blocks in the MHC vary in an HLA haplotype specific manner assessed mainly by DRB1*03 and DRB1*04 haplotypes.
Genes and immunity 2006;7(2):130-40.
2006: Halban Philippe A; Ferrannini Ele; Nerup Jørn
Diabetes research investment in the European Union.
Nature medicine 2006;12(1):70-2.
2006: Johansen A; Jensen D P; Bergholdt R; Mortensen H B; Pociot F; Nerup J; Hansen T; Pedersen O;
IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?
Diabetes, obesity & metabolism 2006;8(1):75-82.
2005: Concannon Patrick; Erlich Henry A; Julier Cecile; Morahan Grant; Nerup Jørn; Pociot Flemming; Todd John A; Rich Stephen S;
Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families.
Diabetes 2005;54(10):2995-3001.
2005: Gylvin T; Bergholdt R; Nerup J; Pociot F
To: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900-905.
Diabetologia 2005;48(10):2183-4.
2005: Sparre T; Ejrnaes Sprinkel A M; Bjerre Christensen U; Karlsen A E; Pociot F; Nerup J
Anaesthesia-induced hyperglycaemia early in life is not predictive for development of diabetes in diabetes-prone BB rats.
Acta diabetologica 2005;42(2):95-8.
2005: Bergholdt Regine; Taxvig Camilla; Eising Stefanie; Nerup Jørn; Pociot Flemming
CBLB variants in type 1 diabetes and their genetic interaction with CTLA4.
Journal of leukocyte biology 2005;77(4):579-85.
2005: Kalbe L; Leunda A; Sparre T; Meulemans C; Ahn M-T; Orntoft T; Kruhoffer M; Reusens B; Nerup J; Remacle C
Nutritional regulation of proteases involved in fetal rat insulin secretion and islet cell proliferation.
The British journal of nutrition 2005;93(3):309-16.
2005: Bergholdt R; Nerup J; Pociot F
Fine mapping of a region on chromosome 21q21.11-q22.3 showing linkage to type 1 diabetes.
Journal of medical genetics 2005;42(1):17-25.
2004: Nielsen K; Kruhøffer M; Orntoft T; Sparre T; Wang H; Wollheim C; Jørgensen M C; Nerup J; Karlsen A E
Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity.
Diabetologia 2004;47(12):2185-99.
2004: Karlsen A E; Heding P E; Frobøse H; Rønn S G; Kruhøffer M; Orntoft T F; Darville M; Eizirik D L; Pociot F; Nerup J; Mandrup-Poulsen T; Billestrup N
Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Diabetologia 2004;47(11):1998-2011.
2004: Johannesen Jesper; Pie Angeles; Karlsen Allan Ertmann; Larsen Zenia Marian; Jensen Allan; Vissing Henrik; Kristiansen Ole Peter; Pociot Flemming; Nerup Jørn;
Is mortalin a candidate gene for T1DM ?
Autoimmunity 2004;37(6-7):423-30.
2004: Gylvin T; Nolsøe R; Hansen T; Nielsen E M D; Bergholdt R; Karlsen A E; Billestrup N; Borch-Johnsen K; Pedersen O; Mandrup-Poulsen T; Nerup J; Pociot F
Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.
Diabetologia 2004;47(7):1273-7.
2004: Sparre T; Christensen U Bjerre; Gotfredsen C F; Larsen P Mose; Fey S J; Hjernø K; Roepstorff P; Pociot F; Karlsen A E; Nerup J
Changes in expression of IL-1 beta influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats.
Diabetologia 2004;47(5):892-908.
2004: Bergholdt R; Ghandil P; Johannesen J; Kristiansen O P; Kockum I; Luthman H; Rønningen K S; Nerup J; Julier C; Pociot F
Genetic and functional evaluation of an interleukin-12 polymorphism (IDDM18) in families with type 1 diabetes.
Journal of medical genetics 2004;41(4):e39.
2004: Pociot Flemming; Karlsen Allan E; Pedersen Claus B; Aalund Mogens; Nerup Jørn;
Novel analytical methods applied to type 1 diabetes genome-scan data.
American journal of human genetics 2004;74(4):647-60.
2004: Larsen Z M; Johannesen J; Kristiansen O P; Nerup J; Pociot F;
Evidence for linkage on chromosome 4p16.1 in Type 1 diabetes Danish families and complete mutation scanning of the WFS1 (Wolframin) gene.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(3):218-22.
2004: Nielsen K; Sparre T; Larsen M R; Nielsen M; Fey S J; Mose Larsen P; Roepstorff P; Nerup J; Karlsen A E
Protein expression changes in a cell system of beta-cell maturation reflect an acquired sensitivity to IL-1beta.
Diabetologia 2004;47(1):62-74.
2004: Bergholdt Regine; Heding Peter; Nielsen Karin; Nolsøe Runa; Sparre Thomas; Størling Joachim; Nerup Jørn; Pociot Flemming; Mandrup-Poulsen Thomas
Type 1 database mellitus: an inflammatory disease of the islet.
Advances in experimental medicine and biology 2004;552():129-53.
2003: Sparre Thomas; Bergholdt Regine; Nerup Jørn; Pociot Flemming
Application of genomics and proteomics in Type 1 diabetes pathogenesis research.
Expert review of molecular diagnostics 2003;3(6):743-57.
2003: Sparre T; Reusens B; Cherif H; Larsen M R; Roepstorff P; Fey S J; Mose Larsen P; Remacle C; Nerup J
Intrauterine programming of fetal islet gene expression in rats--effects of maternal protein restriction during gestation revealed by proteome analysis.
Diabetologia 2003;46(11):1497-511.
2003: Johansson Stefan; Lie Benedicte A; Cambon-Thomsen Anne; Pociot Flemming; Nerup Jørn; Kockum Ingrid; Thorsby Erik; Undlien Dag E
No evidence of type 1 diabetes susceptibility genes in the region centromeric of the HLA complex.
Human immunology 2003;64(10):951-9.
2003: Johannesen Jesper; Karlsen Allan E; Pociot Flemming; Roenn Sif G; Nerup Jørn
Strain dependent rat iNOS promoter activity--correlation to identified WT1 transcription factor binding site.
Autoimmunity 2003;36(3):167-75.
2003: Johansson S; Lie B A; Pociot F; Nerup J; Cambon-Thomsen A; Kockum I; Thorsby E; Undlien D E
HLA associations in type 1 diabetes: DPB1 alleles may act as markers of other HLA-complex susceptibility genes.
Tissue antigens 2003;61(5):344-51.
2003: Sparre Thomas; Sprinkel Anne M Ejrnaes; Christensen Ulla Bjerre; Karlsen Allan E; Pociot Flemming; Nerup Jørn
Prophylactic insulin treatment of syngeneically transplanted pre-diabetic BB-DP rats.
Autoimmunity 2003;36(2):99-109.
2003: Johansson S; Lie B A; Todd J A; Pociot F; Nerup J; Cambon-Thomsen A; Kockum I; Akselsen H E; Thorsby E; Undlien D E
Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and -DRB1.
Genes and immunity 2003;4(1):46-53.
2002: Svensson Jannet; Carstensen Bendix; Mølbak AnneGrete; Christau Bjørn; Mortensen Henrik B; Nerup Jørn; Borch-Johnsen Knut
Increased risk of childhood type 1 diabetes in children born after 1985.
Diabetes care 2002;25(12):2197-201.
2002: Sparre T; Christensen U Bjerre; Mose Larsen P; Fey S J; Wrzesinski K; Roepstorff P; Mandrup-Poulsen T; Pociot F; Karlsen A E; Nerup J
IL-1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis.
Diabetologia 2002;45(11):1550-61.
2002: Gylvin T; Bergholdt R; Nerup J; Pociot F
Characterization of a nuclear-factor-kappa B (NFkappaB) genetic marker in type 1 diabetes (T1DM) families.
Genes and immunity 2002;3(7):430-2.
2002: Field L L; Larsen Z; Pociot F; Nerup J; Tobias R; Bonnevie-Nielsen V
Evidence for a locus (IDDM16) in the immunoglobulin heavy chain region on chromosome 14q32.3 producing susceptibility to type 1 diabetes.
Genes and immunity 2002;3(6):338-44.
2001: Larsen Z M; Angelo A D; Cattaneo M; Nerup J; Biunno I; Zollo M; Pociot F
Complete mutation scanning of the human SEL 1L gene: a candidate gene for type 1 diabetes.
Acta diabetologica 2001;38(4):191-2.
2001: Heding P E; Karlsen A E; Veijola R; Nerup J; Pociot F
No evidence of a functionally significant polymorphism of the BCL2 gene in Danish, Finnish and Basque type 1 diabetes families.
Genes and immunity 2001;2(7):398-400.
2001: Karlsen A E; Rønn S G; Lindberg K; Johannesen J; Galsgaard E D; Pociot F; Nielsen J H; Mandrup-Poulsen T; Nerup J; Billestrup N
Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12191-6.
2001: Remacle C; Reusens B; Kalbe L; Hales C N; Ozanne S E; Bréant B; Polak M; Rees W D; McKinnon C M; Olsen S F; Nerup J; Tamarit J; Reik W
Early malnutrition and programming of adult degenerative diseases: experimental, epidemiological and preventive studies.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2001;11(4 Suppl):99-102.
2001: Johannesen J; Pociot F; Karlsen A E; Mandrup-Poulsen T; Nerup J
Strain-dependent difference in inducible nitric oxide synthesis (iNOS) expression in rat pancreatic islets correlates with interferon regulating factor 1 (IRF-1) and heat shock protein 70 (HSP70) expression.
European cytokine network 2001;12(3):501-9.
2001: Pociot F; Larsen Z M; Zavattari P; Deidda E; Nerup J; Cattaneo M; Chiaramonte R; Comi P; Sabbadini M; Zollo M; Biunno I; Cucca F
No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility.
Diabetes/metabolism research and reviews 2001;17(4):292-5.
2001: Johannesen J; Pie A; Pociot F; Kristiansen O P; Karlsen A E; Nerup J;
Linkage of the human inducible nitric oxide synthase gene to type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2001;86(6):2792-6.
2001: Larsen P M; Fey S J; Larsen M R; Nawrocki A; Andersen H U; Kähler H; Heilmann C; Voss M C; Roepstorff P; Pociot F; Karlsen A E; Nerup J
Proteome analysis of interleukin-1beta--induced changes in protein expression in rat islets of Langerhans.
Diabetes 2001;50(5):1056-63.
2001: Karlsen A E; Sparre T; Nielsen K; Nerup J; Pociot F
Proteome analysis--a novel approach to understand the pathogenesis of Type 1 diabetes mellitus.
Disease markers 2001;17(4):205-16.
2000: Bergholdt R; Larsen Z M; Andersen N A; Johannesen J; Kristiansen O P; Mandrup-Poulsen T; Nerup J; Pociot F;
Characterization of new polymorphisms in the 5' UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level.
Genes and immunity 2000;1(8):495-500.
2000: Kristiansen O P; Nolsøe R L; Holst H; Reker S; Larsen Z M; Johannesen J; Nerup J; Pociot F; Mandrup-Poulsen T;
The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes.
Immunogenetics 2000;52(1-2):107-11.
2000: John N E; Andersen H U; Fey S J; Larsen P M; Roepstorff P; Larsen M R; Pociot F; Karlsen A E; Nerup J; Green I C; Mandrup-Poulsen T
Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.
Diabetes 2000;49(11):1819-29.
2000: Johannesen J; Pociot F; Kristiansen O P; Karlsen A E; Nerup J;
No evidence for linkage in the promoter region of the inducible nitric oxide synthase gene (NOS2) in a Danish type 1 diabetes population.
Genes and immunity 2000;1(6):362-6.
2000: Nolsøe R L; Kristiansen O P; Sangthongpitag K; Larsen Z M; Johannesen J; Karlsen A E; Pociot F; Nerup J; Verge C F; Mandrup-Poulsen T
Complete molecular scanning of the human Fas gene: mutational analysis and linkage studies in families with type I diabetes mellitus. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
Diabetologia 2000;43(6):800-8.
2000: Kristiansen O P; Pociot F; Bennett E P; Clausen H; Johannesen J; Nerup J; Mandrup-Poulsen T
IDDM7 links to insulin-dependent diabetes mellitus in Danish multiplex families but linkage is not explained by novel polymorphisms in the candidate gene GALNT3. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
Human mutation 2000;15(3):295-6.
2000: Karlsen A E; Pavlovic D; Nielsen K; Jensen J; Andersen H U; Pociot F; Mandrup-Poulsen T; Eizirik D L; Nerup J
Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism.
The Journal of clinical endocrinology and metabolism 2000;85(2):830-6.
2000: Kristiansen O P; Pociot F; Johannesen J; Bergholdt R; Dinarello C A; Nerup J; Mandrup-Poulsen T
Linkage disequilibrium testing of four interleukin-1 gene-cluster polymorphisms in Danish multiplex families with insulin-dependent diabetes mellitus.
Cytokine 2000;12(2):171-5.
2000: Christensen U B; Larsen P M; Fey S J; Andersen H U; Nawrocki A; Sparre T; Mandrup-Poulsen T; Nerup J
Islet protein expression changes during diabetes development in islet syngrafts in BB-DP rats and during rejection of BB-DP islet allografts.
Autoimmunity 2000;32(1):1-15.
1999: Nielsen K; Karlsen A E; Deckert M; Madsen O D; Serup P; Mandrup-Poulsen T; Nerup J
Beta-cell maturation leads to in vitro sensitivity to cytotoxins.
Diabetes 1999;48(12):2324-32.
1999: O'Brien T; Karlsen A E; Andersen H U; Mandrup-Poulsen T; Nerup J
Absence of toxicity associated with adenoviral-mediated transfer of the beta-galactosidase reporter gene to neonatal rat islets in vitro.
Diabetes research and clinical practice 1999;44(3):157-63.
1999: Lorenzen T; Pociot F; Johannesen J; Kristiansen O P; Nerup J
A population-based survey of frequencies of self-reported spontaneous and induced abortions in Danish women with Type 1 diabetes mellitus. Danish IDDM Epidemiology and Genetics Group.
Diabetic medicine : a journal of the British Diabetic Association 1999;16(6):472-6.
1999: Parving H H; Tarnow L; Nielsen F S; Rossing P; Mandrup-Poulsen T; Osterby R; Nerup J
Cyclosporine nephrotoxicity in type 1 diabetic patients. A 7-year follow-up study.
Diabetes care 1999;22(3):478-83.
1999: Lie B A; Todd J A; Pociot F; Nerup J; Akselsen H E; Joner G; Dahl-Jørgensen K; Rønningen K S; Thorsby E; Undlien D E
The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene.
American journal of human genetics 1999;64(3):793-800.
1999: Larsen Z M; Kristiansen O P; Mato E; Johannesen J; Puig-Domingo M; de Leiva A; Nerup J; Pociot F
IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34 in genetic susceptibility to type 1 diabetes (insulin-dependent).
Autoimmunity 1999;31(1):35-42.
1999: Kristiansen O P; Larsen Z M; Johannesen J; Nerup J; Mandrup-Poulsen T; Pociot F
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
Human mutation 1999;14(1):67-70.
1998: Møller A M; Dalgaard L T; Pociot F; Nerup J; Hansen T; Pedersen O
Mutations in the hepatocyte nuclear factor-1alpha gene in Caucasian families originally classified as having Type I diabetes.
Diabetologia 1998;41(12):1528-31.
1998: Pociot F; Hansen P M; Karlsen A E; Langdahl B L; Johannesen J; Nerup J
TGF-beta1 gene mutations in insulin-dependent diabetes mellitus and diabetic nephropathy.
Journal of the American Society of Nephrology : JASN 1998;9(12):2302-7.
1998: Esposito L; Hill N J; Pritchard L E; Cucca F; Muxworthy C; Merriman M E; Wilson A; Julier C; Delepine M; Tuomilehto J; Tuomilehto-Wolf E; Ionesco-Tirgoviste C; Nistico' L; Buzzetti R; Pozzilli P; Ferrari M; Bosi E; Pociot F; Nerup J; Bain S C; Todd J A
Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group.
Diabetes 1998;47(11):1797-9.
1998: Nakagawa Y; Kawaguchi Y; Twells R C; Muxworthy C; Hunter K M; Wilson A; Merriman M E; Cox R D; Merriman T; Cucca F; McKinney P A; Shield J P; Tuomilehto J; Tuomilehto-Wolf E; Ionesco-Tirgoviste C; Nisticò L; Buzzetti R; Pozzilli P; Joner G; Thorsby E; Undlien D E; Pociot F; Nerup J; Rönningen K S; Bain S C; Todd J A;
Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13.
American journal of human genetics 1998;63(2):547-56.
1998: Duun E H; Nygaard B; Nerup J
[Thyrotoxicosis at the onset of diabetes mellitus. Report of five cases]
Ugeskrift for laeger 1998;160(29):4327-30.
1998: Lorenzen T; Pociot F; Stilgren L; Kristiansen O P; Johannesen J; Olsen P B; Walmar A; Larsen A; Albrechtsen N C; Eskildsen P C; Andersen O O; Nerup J
Predictors of IDDM recurrence risk in offspring of Danish IDDM patients. Danish IDDM Epidemiology and Genetics Group.
Diabetologia 1998;41(6):666-73.
1998: Merriman T R; Eaves I A; Twells R C; Merriman M E; Danoy P A; Muxworthy C E; Hunter K M; Cox R D; Cucca F; McKinney P A; Shield J P; Baum J D; Tuomilehto J; Tuomilehto-Wolf E; Ionesco-Tirgoviste C; Joner G; Thorsby E; Undlien D E; Pociot F; Nerup J; Ronningen K S; Bain S C; Todd J A
Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6).
Human molecular genetics 1998;7(3):517-24.
1998: Kristiansen O P; Zamani M; Johannesen J; Mandrup-Poulsen T; Cassiman J J; Nerup J; Pociot F
Linkage and association between a CD4 gene polymorphism and IDDM in Danish IDDM patients. The Danish IDDM Epidemiology and Genetics Group, and The Danish Study Group of Diabetes in Childhood.
Diabetes 1998;47(2):281-3.
1998: Christensen U B; Sparre T; Cooke A; Andersen H U; Mandrup-Poulsen T; Nerup J
Syngeneic islet transplantation in prediabetic BB-DP rats--a synchronized model for studying beta-cell destruction during the development of IDDM.
Autoimmunity 1998;28(2):91-107.
1997: Bennett S T; Wilson A J; Esposito L; Bouzekri N; Undlien D E; Cucca F; Nisticò L; Buzzetti R; Bosi E; Pociot F; Nerup J; Cambon-Thomsen A; Pugliese A; Shield J P; McKinney P A; Bain S C; Polychronakos C; Todd J A
Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.
Nature genetics 1997;17(3):350-2.
1997: Johannesen J; Karlsen A E; Nerup J; Pociot F
No association or linkage to IDDM of an interferon regulatory factor-1 gene polymorphism in a Danish population. The Danish Study Group for Diabetes in Childhood.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 1997;24(5):377-83.
1997: Andersen H U; Fey S J; Larsen P M; Nawrocki A; Hejnaes K R; Mandrup-Poulsen T; Nerup J
Interleukin-1beta induced changes in the protein expression of rat islets: a computerized database.
Electrophoresis 1997;18(11):2091-103.
1997: Mauricio D; Andersen H U; Larsen C M; Karlsen A E; Mandrup-Poulsen T; Nerup J
Dexamethasone prevents interleukin-1beta-mediated inhibition of rat islet insulin secretion without decreasing nitric oxide production.
Cytokine 1997;9(8):563-9.
1997: Merriman T; Twells R; Merriman M; Eaves I; Cox R; Cucca F; McKinney P; Shield J; Baum D; Bosi E; Pozzilli P; Nisticò L; Buzzetti R; Joner G; Rønningen K S; Thorsby E; Undlien D; Pociot F; Nerup J; Bain S; Barnett A; Todd J
Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21.
Human molecular genetics 1997;6(7):1003-10.
1997: Pociot F; Veijola R; Johannesen J; Hansen P M; Lorenzen T; Karlsen A E; Reijonen H; Knip M; Nerup J
Analysis of an interferon-gamma gene (IFNG) polymorphism in Danish and Finnish insulin-dependent diabetes mellitus (IDDM) patients and control subjects. Danish Study Group of Diabetes in Childhood.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997;17(2):87-93.
1997: Delépine M; Pociot F; Habita C; Hashimoto L; Froguel P; Rotter J; Cambon-Thomsen A; Deschamps I; Djoulah S; Weissenbach J; Nerup J; Lathrop M; Julier C
Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6.
American journal of human genetics 1997;60(1):174-87.
1996: Zamani M; Pociot F; Spaepen M; Raeymaekers P; Nerup J; Cassiman J J
Linkage and association of the HLA gene complex with IDDM in 81 Danish families: strong linkage between DR beta 1Lys71+ and IDDM.
Journal of medical genetics 1996;33(11):899-905.
1996: Metcalfe K A; Hitman G A; Pociot F; Bergholdt R; Tuomilehto-Wolf E; Tuomilehto J; Viswanathan M; Ramachandran A; Nerup J
An association between type 1 diabetes and the interleukin-1 receptor type 1 gene. The DiMe Study Group. Childhood Diabetes in Finland.
Human immunology 1996;51(1):41-8.
1996: Thorsteinsson S L; Hansen A; Thorsteinsson B; Nerup J; Koch C
[Glucose tolerance in patients with cystic fibrosis]
Ugeskrift for laeger 1996;158(44):6269-73.
1996: Reimers J I; Rasmussen A K; Karlsen A E; Bjerre U; Liang H; Morin O; Andersen H U; Mandrup-Poulsen T; Burger A G; Feldt-Rasmussen U; Nerup J
Interleukin-1 beta inhibits rat thyroid cell function in vivo and in vitro by an NO-independent mechanism and induces hypothyroidism and accelerated thyroiditis in diabetes-prone BB rats.
The Journal of endocrinology 1996;151(1):147-57.
1996: Zamani M; Pociot F; Raeymaekers P; Nerup J; Cassiman J J
Linkage of type I diabetes to 15q26 (IDDM3) in the Danish population.
Human genetics 1996;98(4):491-6.
1996: Bennett S T; Wilson A J; Cucca F; Nerup J; Pociot F; McKinney P A; Barnett A H; Bain S C; Todd J A
IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.
Journal of autoimmunity 1996;9(3):415-21.
1996: Reimers J I; Andersen H U; Mauricio D; Pociot F; Karlsen A E; Petersen J S; Mandrup-Poulsen T; Nerup J
Strain-dependent differences in sensitivity of rat beta-cells to interleukin 1 beta in vitro and in vivo: association with islet nitric oxide synthesis.
Diabetes 1996;45(6):771-8.
1996: Mauricio D; Mandrup-Poulsen T; Nerup J
Vitamin D analogues in insulin-dependent diabetes mellitus and other autoimmune diseases: a therapeutic perspective.
Diabetes/metabolism reviews 1996;12(1):57-68.
1996: Andersen H U; Mauricio D; Karlsen A E; Mandrup-Poulsen T; Nielsen J H; Nerup J
Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(2):251-9.
1996: Mandrup-Poulsen T; Nerup J; Reimers J I; Pociot F; Andersen H U; Karlsen A; Bjerre U; Bergholdt R
Cytokines and the endocrine system. II. Roles in substrate metabolism, modulation of thyroidal and pancreatic endocrine cell functions and autoimmune endocrine diseases.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(1):21-30.
1996: Christensen U B; Mauricio D; Reimers J I; Andersen H U; Kalland T; Nerup J; Mandrup-Poulsen T
Linomide increases plasma corticosterone in normal rats, but does not prevent the inhibitory action of IL-1 on beta-cells in vivo or ex vivo.
Autoimmunity 1996;23(4):257-68.
1995: Mandrup-Poulsen T; Nerup J; Reimers J I; Pociot F; Andersen H U; Karlsen A; Bjerre U; Bergholdt R
Cytokines and the endocrine system. I. The immunoendocrine network.
European journal of endocrinology / European Federation of Endocrine Societies 1995;133(6):660-71.
1995: Bergholdt R; Karlsen A E; Johannesen J; Hansen P M; Dinarello C A; Nerup J; Pociot F
Characterization of polymorphisms of an interleukin 1 receptor type 1 gene (IL1RI) promotor region (P2) and their relation to insulin-dependent diabetes mellitus (IDDM). The Danish Study Group of Diabetes in Childhood.
Cytokine 1995;7(7):727-33.
1995: Lanng S; Hansen A; Thorsteinsson B; Nerup J; Koch C
Glucose tolerance in patients with cystic fibrosis: five year prospective study.
BMJ (Clinical research ed.) 1995;311(7006):655-9.
1995: Andersen H U; Larsen P M; Fey S J; Karlsen A E; Mandrup-Poulsen T; Nerup J
Two-dimensional gel electrophoresis of rat islet proteins. Interleukin 1 beta-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide.
Diabetes 1995;44(4):400-7.
1995: Mandrup-Poulsen T; Wogensen L D; Jensen M; Svensson P; Nilsson P; Emdal T; Mølvig J; Dinarello C A; Nerup J
Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury.
Critical care medicine 1995;23(1):26-33.
1994: Petersen J S; Dyrberg T; Karlsen A E; Mølvig J; Michelsen B; Nerup J; Mandrup-Poulsen T
Glutamic acid decarboxylase (GAD65) autoantibodies in prediction of beta-cell function and remission in recent-onset IDDM after cyclosporin treatment. The Canadian-European Randomized Control Trial Group.
Diabetes 1994;43(11):1291-6.
1994: Mandrup-Poulsen T; Pociot F; Mølvig J; Shapiro L; Nilsson P; Emdal T; Røder M; Kjems L L; Dinarello C A; Nerup J
Monokine antagonism is reduced in patients with IDDM.
Diabetes 1994;43(10):1242-7.
1994: Nerup J; Mandrup-Poulsen T; Helqvist S; Andersen H U; Pociot F; Reimers J I; Cuartero B G; Karlsen A E; Bjerre U; Lorenzen T
On the pathogenesis of IDDM.
Diabetologia 1994;37 Suppl 2():S82-9.
1994: Reimers J I; Bjerre U; Mandrup-Poulsen T; Nerup J
Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases.
Cytokine 1994;6(5):512-20.
1994: Nørgaard K; Pociot F; Hobolth N; Andersen O; Nerup J
[Familial aggregation of insulin-dependent diabetes mellitus in Denmark. A nation-wide population study]
Ugeskrift for laeger 1994;156(33):4710-3.
1994: Lanng S; Thorsteinsson B; Nerup J; Koch C
Diabetes mellitus in cystic fibrosis: effect of insulin therapy on lung function and infections.
Acta paediatrica (Oslo, Norway : 1992) 1994;83(8):849-53.
1994: Lanng S; Thorsteinsson B; Røder M E; Nerup J; Koch C
Insulin sensitivity and insulin clearance in cystic fibrosis patients with normal and diabetic glucose tolerance.
Clinical endocrinology 1994;41(2):217-23.
1994: Andersen H U; Jørgensen K H; Egeberg J; Mandrup-Poulsen T; Nerup J
Nicotinamide prevents interleukin-1 effects on accumulated insulin release and nitric oxide production in rat islets of Langerhans.
Diabetes 1994;43(6):770-7.
1994: Gerling I C; Karlsen A E; Chapman H D; Andersen H U; Boel E; Cunningham J M; Nerup J; Leiter E H
The inducible nitric oxide synthase gene, Nos2, maps to mouse chromosome 11.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(5):318-20.
1994: Lorenzen T; Pociot F; Hougaard P; Nerup J
Long-term risk of IDDM in first-degree relatives of patients with IDDM.
Diabetologia 1994;37(3):321-7.
1994: Lanng S; Thorsteinsson B; Lund-Andersen C; Nerup J; Schiøtz P O; Koch C
Diabetes mellitus in Danish cystic fibrosis patients: prevalence and late diabetic complications.
Acta paediatrica (Oslo, Norway : 1992) 1994;83(1):72-7.
1994: Reimers J I; Mørch L; Markholst H; Wogensen L D; Andersen H U; Mandrup-Poulsen T; Nerup J
Interleukin-1 beta (IL-1) does not reduce the diabetes incidence in diabetes-prone BB rats.
Autoimmunity 1994;17(2):105-18.
1994: Pociot F; Rønningen K S; Bergholdt R; Lorenzen T; Johannesen J; Ye K; Dinarello C A; Nerup J
Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes--evidence for polygenicity in man. Danish Study Group of Diabetes in Childhood.
Autoimmunity 1994;19(3):169-78.
1993: Mandrup-Poulsen T; Reimers J I; Andersen H U; Pociot F; Karlsen A E; Bjerre U; Nerup J
Nicotinamide treatment in the prevention of insulin-dependent diabetes mellitus.
Diabetes/metabolism reviews 1993;9(4):295-309.
1993: Pociot F; Lorenzen T; Nerup J
A manganese superoxide dismutase (SOD2) gene polymorphism in insulin-dependent diabetes mellitus.
Disease markers 1993;11(5-6):267-74.
1993: Pociot F; Wilson A G; Nerup J; Duff G W
No independent association between a tumor necrosis factor-alpha promotor region polymorphism and insulin-dependent diabetes mellitus.
European journal of immunology 1993;23(11):3050-3.
1993: Pociot F; Rønningen K S; Nerup J
Polymorphic analysis of the human MHC-linked heat shock protein 70 (HSP70-2) and HSP70-Hom genes in insulin-dependent diabetes mellitus (IDDM).
Scandinavian journal of immunology 1993;38(5):491-5.
1993: Pociot F; Nørgaard K; Hobolth N; Andersen O; Nerup J
A nationwide population-based study of the familial aggregation of type 1 (insulin-dependent) diabetes mellitus in Denmark. Danish Study Group of Diabetes in Childhood.
Diabetologia 1993;36(9):870-5.
1993: Zumsteg U; Reimers J I; Pociot F; Mørch L; Helqvist S; Brendel M; Alejandro R; Mandrup-Poulsen T; Dinarello C A; Nerup J
Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats.
Diabetologia 1993;36(8):759-66.
1993: Wogensen L; Jensen M; Svensson P; Worsaae H; Welinder B; Nerup J
Pancreatic beta-cell function and interleukin-1 beta in plasma during the acute phase response in patients with major burn injuries.
European journal of clinical investigation 1993;23(5):311-9.
1993: Mandrup-Poulsen T; Zumsteg U; Reimers J; Pociot F; Mørch L; Helqvist S; Dinarello C A; Nerup J
Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic beta-cell destruction in insulin-dependent diabetes mellitus.
Cytokine 1993;5(3):185-91.
1993: Lanng S; Thorsteinsson B; Røder M E; Orskov C; Holst J J; Nerup J; Koch C
Pancreas and gut hormone responses to oral glucose and intravenous glucagon in cystic fibrosis patients with normal, impaired, and diabetic glucose tolerance.
Acta endocrinologica 1993;128(3):207-14.
1993: Lanng S; Thorsteinsson B; Pociot F; Marshall M O; Madsen H O; Schwartz M; Nerup J; Koch C
Diabetes mellitus in cystic fibrosis: genetic and immunological markers.
Acta paediatrica (Oslo, Norway : 1992) 1993;82(2):150-4.
1993: Pociot F; Briant L; Jongeneel C V; Mölvig J; Worsaae H; Abbal M; Thomsen M; Nerup J; Cambon-Thomsen A
Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus.
European journal of immunology 1993;23(1):224-31.
1992: Lanng S; Thorsteinsson B; Nerup J; Koch C
Influence of the development of diabetes mellitus on clinical status in patients with cystic fibrosis.
European journal of pediatrics 1992;151(9):684-7.
1992: Pociot F; Mølvig J; Wogensen L; Worsaae H; Nerup J
A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro.
European journal of clinical investigation 1992;22(6):396-402.
1992: Wogensen L D; Reimers J; Nerup J; Kolb-Bachofen V; Kröncke K D; Almdal T; Mandrup-Poulsen T
Repetitive in vivo treatment with human recombinant interleukin-1 beta modifies beta-cell function in normal rats.
Diabetologia 1992;35(4):331-9.
1991: Reimers J; Wogensen L D; Welinder B; Hejnaes K R; Poulsen S S; Nilsson P; Nerup J
The pharmacokinetics, distribution and degradation of human recombinant interleukin 1 beta in normal rats.
Scandinavian journal of immunology 1991;34(5):597-610.
1991: Lanng S; Thorsteinsson B; Erichsen G; Nerup J; Koch C
Glucose tolerance in cystic fibrosis.
Archives of disease in childhood 1991;66(5):612-6.
1991: Wogensen L; Reimers J; Mandrup-Poulsen T; Nerup J
Repeated intraperitoneal injections of interleukin 1 beta induce glucose intolerance in normal rats.
Acta endocrinologica 1991;124(4):470-8.
1991: Helqvist S; Polla B S; Johannesen J; Nerup J
Heat shock protein induction in rat pancreatic islets by recombinant human interleukin 1 beta.
Diabetologia 1991;34(3):150-6.
1991: Pociot F; Mølvig J; Wogensen L; Worsaae H; Dalbøge H; Baek L; Nerup J
A tumour necrosis factor beta gene polymorphism in relation to monokine secretion and insulin-dependent diabetes mellitus.
Scandinavian journal of immunology 1991;33(1):37-49.
1991: Helqvist S; Zumsteg U W; Spinas G A; Palmer J P; Mandrup-Poulsen T; Egeberg J; Nerup J
Repetitive exposure of pancreatic islets to interleukin-1 beta. An in vitro model of pre-diabetes?
Autoimmunity 1991;10(4):311-8.
1990: Johannesen J; Helqvist S; Nerup J
Not all insulin secretagogues sensitize pancreatic islets to recombinant human interleukin 1 beta.
Acta endocrinologica 1990;123(4):445-52.
1990: Mølvig J; Pociot F; Baek L; Worsaae H; Dall Wogensen L; Christensen P; Staub-Nielsen L; Mandrup-Poulsen T; Manogue K; Nerup J
Monocyte function in IDDM patients and healthy individuals.
Scandinavian journal of immunology 1990;32(3):297-311.
1990: Helqvist S; Bouchelouche P N; Johannesen J; Nerup J
Interleukin 1 beta increases the cytosolic free sodium concentration in isolated rat islets of Langerhans.
Scandinavian journal of immunology 1990;32(1):53-8.
1990: Mølvig J; Sehested Hansen B; Worsaae H; Hejnaes K R; Helle M; Dalbøge H; Nerup J
Comparison of biological and immunological activities of human monocyte-derived interleukin 1 beta and human recombinant interleukin 1 beta.
Scandinavian journal of immunology 1990;31(2):225-35.
1990: Wogensen L D; Kolb-Bachofen V; Christensen P; Dinarello C A; Mandrup-Poulsen T; Martin S; Nerup J
Functional and morphological effects of interleukin-1 beta on the perfused rat pancreas.
Diabetologia 1990;33(1):15-23.
1990: Wogensen L; Helqvist S; Pociot F; Johannesen J; Reimers J; Mandrup-Poulsen T; Nerup J
Intra-peritoneal administration of interleukin-1 beta induces impaired insulin release from the perfused rat pancreas.
Autoimmunity 1990;7(1):1-12.
1990: Mandrup-Poulsen T; Helqvist S; Wogensen L D; Mølvig J; Pociot F; Johannesen J; Nerup J
Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells.
Current topics in microbiology and immunology 1990;164():169-93.
1989: Mølvig J; Sønderstrup McDevitt G; Thomsen M; Bosmann B; Blangero C; de Preval C; Baek L; Nerup J
Characterization of PPD-specific T-cell lines generated in type I (insulin-dependent) diabetic and healthy individuals.
Scandinavian journal of immunology 1989;30(5):615-29.
1989: Palmer J P; Helqvist S; Spinas G A; Mølvig J; Mandrup-Poulsen T; Andersen H U; Nerup J
Interaction of beta-cell activity and IL-1 concentration and exposure time in isolated rat islets of Langerhans.
Diabetes 1989;38(10):1211-6.
1989: Helqvist S; Bouchelouche P; Andersen H U; Nerup J
Modulation of calcium flux influences interleukin 1 beta effects on insulin release from isolated islets of Langerhans.
Acta endocrinologica 1989;121(3):447-55.
1989: Helqvist S; Sehested Hansen B; Johannesen J; Ullits Andersen H; Hoiriis Nielsen J; Nerup J
Interleukin 1 induces new protein formation in isolated rat islets of Langerhans.
Acta endocrinologica 1989;121(1):136-40.
1989: Andersen H U; Mandrup-Poulsen T; Egeberg J; Helqvist S; Nerup J
Genetically determined differences in newborn rat islet sensitivity to interleukin-1 in vitro: no association with the diabetes prone phenotype in the BB-rat.
Acta endocrinologica 1989;120(1):92-8.
1989: Zerbib A; Mølvig J; Thomsen M; Coppin H; Cambon-Thomsen A; Sommer E; Nerup J; De Preval C
Restriction fragment length polymorphism of HLA and non-HLA genes in DR3/4 heterozygous Danish insulin-dependent diabetic patients and healthy individuals: reassessment of the influence of alpha DX and insulin-linked polymorphic loci, and new splits of DQw3 haplotypes.
Disease markers 1989;7(1):27-41.
1989: Mandrup-Poulsen T; Helqvist S; Mølvig J; Wogensen L D; Nerup J
Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus.
Autoimmunity 1989;4(3):191-218; discussion 219-34.
1988: Nerup J; Mandrup-Poulsen T; Mølvig J; Helqvist S; Wogensen L; Egeberg J
Mechanisms of pancreatic beta-cell destruction in type I diabetes.
Diabetes care 1988;11 Suppl 1():16-23.
1988: Spinas G A; Palmer J P; Mandrup-Poulsen T; Andersen H; Nielsen J H; Nerup J
The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration.
Acta endocrinologica 1988;119(2):307-11.
1988: Mølvig J; Baek L; Christensen P; Manogue K R; Vlassara H; Platz P; Nielsen L S; Svejgaard A; Nerup J
Endotoxin-stimulated human monocyte secretion of interleukin 1, tumour necrosis factor alpha, and prostaglandin E2 shows stable interindividual differences.
Scandinavian journal of immunology 1988;27(6):705-16.
1988: Wogensen L D; Mandrup-Poulsen T; Markholst H; Mølvig J; Lernmark A; Holst J J; Dinarello C A; Nerup J
Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas.
Acta endocrinologica 1988;117(3):302-6.
1988: Thomsen M; Mølvig J; Zerbib A; de Preval C; Abbal M; Dugoujon J M; Ohayon E; Svejgaard A; Cambon-Thomsen A; Nerup J
The susceptibility to insulin-dependent diabetes mellitus is associated with C4 allotypes independently of the association with HLA-DQ alleles in HLA-DR3,4 heterozygotes.
Immunogenetics 1988;28(5):320-7.
1988: Hansen B S; Nielsen J H; Linde S; Spinas G A; Welinder B S; Mandrup-Poulsen T; Nerup J
Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets.
Biomedica biochimica acta 1988;47(4-5):305-9.
1987: Mandrup-Poulsen T; Bendtzen K; Dinarello C A; Nerup J
Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(12):4077-82.
1987: Spinas G A; Hansen B S; Linde S; Kastern W; Mølvig J; Mandrup-Poulsen T; Dinarello C A; Nielsen J H; Nerup J
Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans.
Diabetologia 1987;30(7):474-80.
1987: Mandrup-Poulsen T; Spinas G A; Prowse S J; Hansen B S; Jørgensen D W; Bendtzen K; Nielsen J H; Nerup J
Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics.
Diabetes 1987;36(5):641-7.
1987: Mandrup-Poulsen T; Egeberg J; Nerup J; Bendtzen K; Nielsen J H; Dinarello C A
Ultrastructural studies of time-course and cellular specificity of interleukin-1 mediated islet cytotoxicity.
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology 1987;95(2):55-63.
1986: Spinas G A; Mandrup-Poulsen T; Mølvig J; Baek L; Bendtzen K; Dinarello C A; Nerup J
Low concentrations of interleukin-1 stimulate and high concentrations inhibit insulin release from isolated rat islets of Langerhans.
Acta endocrinologica 1986;113(4):551-8.
1986: Mandrup-Poulsen T; Bendtzen K; Nerup J; Egeberg J; Nielsen J H
Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans.
Allergy 1986;41(4):250-9.

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