Eric Nestler

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Covington Herbert E; Maze Ian; LaPlant Quincey C; Vialou Vincent F; Ohnishi Yoshinori N; Berton Olivier; Fass Dan M; Renthal William; Rush Augustus J; Wu Emma Y; Ghose Subroto; Krishnan Vaishnav; Russo Scott J; Tamminga Carol; Haggarty Stephen J; Nestler Eric J
Antidepressant actions of histone deacetylase inhibitors.
Berton Olivier; Guigoni Céline; Li Qin; Bioulac Bernard H; Aubert Incarnation; Gross Christian E; Dileone Ralph J; Nestler Eric J; Bezard Erwan
Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease.
Winstanley Catharine A; Green Thomas A; Theobald David E H; Renthal William; LaPlant Quincey; DiLeone Ralph J; Chakravarty Sumana; Nestler Eric J
DeltaFosB induction in orbitofrontal cortex potentiates locomotor sensitization despite attenuating the cognitive dysfunction caused by cocaine.

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All Publications

2009: Covington Herbert E; Maze Ian; LaPlant Quincey C; Vialou Vincent F; Ohnishi Yoshinori N; Berton Olivier; Fass Dan M; Renthal William; Rush Augustus J; Wu Emma Y; Ghose Subroto; Krishnan Vaishnav; Russo Scott J; Tamminga Carol; Haggarty Stephen J; Nestler Eric J
Antidepressant actions of histone deacetylase inhibitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(37):11451-60.
2009: Berton Olivier; Guigoni Céline; Li Qin; Bioulac Bernard H; Aubert Incarnation; Gross Christian E; Dileone Ralph J; Nestler Eric J; Bezard Erwan
Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease.
Biological psychiatry 2009;66(6):554-61.
2009: Winstanley Catharine A; Green Thomas A; Theobald David E H; Renthal William; LaPlant Quincey; DiLeone Ralph J; Chakravarty Sumana; Nestler Eric J
DeltaFosB induction in orbitofrontal cortex potentiates locomotor sensitization despite attenuating the cognitive dysfunction caused by cocaine.
Pharmacology, biochemistry, and behavior 2009;93(3):278-84.
2009: Watanabe Hiroyuki; Henriksson Richard; Ohnishi Yoshinori N; Ohnishi Yoko H; Harper Clive; Sheedy Donna; Garrick Therese; Nyberg Fred; Nestler Eric J; Bakalkin Georgy; Yakovleva Tatjana
FOSB proteins in the orbitofrontal and dorsolateral prefrontal cortices of human alcoholics.
Addiction biology 2009;14(3):294-7.
2009: Hedges V L; Chakravarty S; Nestler E J; Meisel R L
Delta FosB overexpression in the nucleus accumbens enhances sexual reward in female Syrian hamsters.
Genes, brain, and behavior 2009;8(4):442-9.
2009: Renthal William; Nestler Eric J
Histone acetylation in drug addiction.
Seminars in cell & developmental biology 2009;20(4):387-94.
2009: Wilkinson Matthew B; Xiao Guanghua; Kumar Arvind; LaPlant Quincey; Renthal William; Sikder Devanjan; Kodadek Thomas J; Nestler Eric J
Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(24):7820-32.
2009: Feder Adriana; Nestler Eric J; Charney Dennis S
Psychobiology and molecular genetics of resilience.
Nature reviews. Neuroscience 2009;10(6):446-57.
2009: Renthal William; Kumar Arvind; Xiao Guanghua; Wilkinson Matthew; Covington Herbert E; Maze Ian; Sikder Devanjan; Robison Alfred J; LaPlant Quincey; Dietz David M; Russo Scott J; Vialou Vincent; Chakravarty Sumana; Kodadek Thomas J; Stack Ashley; Kabbaj Mohamed; Nestler Eric J
Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.
Neuron 2009;62(3):335-48.
2009: Dietz D M; Dietz K C; Nestler E J; Russo S J
Molecular mechanisms of psychostimulant-induced structural plasticity.
Pharmacopsychiatry 2009;42 Suppl 1():S69-78.
2009: LaPlant Quincey; Chakravarty Sumana; Vialou Vincent; Mukherjee Shibani; Koo Ja Wook; Kalahasti Geetha; Bradbury Kathryn R; Taylor Shameeke V; Maze Ian; Kumar Arvind; Graham Ami; Birnbaum Shari G; Krishnan Vaishnav; Truong Hoang-Trang; Neve Rachael L; Nestler Eric J; Russo Scott J
Role of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female mice.
Biological psychiatry 2009;65(10):874-80.
2009: Freet Christopher S; Steffen Cathy; Nestler Eric J; Grigson Patricia S
Overexpression of DeltaFosB is associated with attenuated cocaine-induced suppression of saccharin intake in mice.
Behavioral neuroscience 2009;123(2):397-407.
2009: Graham Danielle L; Krishnan Vaishnav; Larson Erin B; Graham Ami; Edwards Scott; Bachtell Ryan K; Simmons Diana; Gent Lana M; Berton Olivier; Bolanos Carlos A; DiLeone Ralph J; Parada Luis F; Nestler Eric J; Self David W
Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward.
Biological psychiatry 2009;65(8):696-701.
2009: Russo Scott J; Wilkinson Matthew B; Mazei-Robison Michelle S; Dietz David M; Maze Ian; Krishnan Vaishnav; Renthal William; Graham Ami; Birnbaum Shari G; Green Thomas A; Robison Bruce; Lesselyong Alan; Perrotti Linda I; Bolaños Carlos A; Kumar Arvind; Clark Michael S; Neumaier John F; Neve Rachael L; Bhakar Asha L; Barker Philip A; Nestler Eric J
Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(11):3529-37.
2009: Lutter Michael; Nestler Eric J
Homeostatic and hedonic signals interact in the regulation of food intake.
The Journal of nutrition 2009;139(3):629-32.
2009: Dinieri Jennifer A; Nemeth Christina L; Parsegian Aram; Carle Tiffany; Gurevich Vsevolod V; Gurevich Eugenia; Neve Rachael L; Nestler Eric J; Carlezon William A
Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(6):1855-9.
2009: Wallace Deanna L; Han Ming-Hu; Graham Danielle L; Green Thomas A; Vialou Vincent; Iñiguez Sergio D; Cao Jun-Li; Kirk Anne; Chakravarty Sumana; Kumar Arvind; Krishnan Vaishnav; Neve Rachael L; Cooper Don C; Bolaños Carlos A; Barrot Michel; McClung Colleen A; Nestler Eric J
CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits.
Nature neuroscience 2009;12(2):200-9.
2009: Nestler Eric J
Epigenetic mechanisms in psychiatry.
Biological psychiatry 2009;65(3):189-90.
2009: Winstanley Catharine A; Bachtell Ryan K; Theobald David E H; Laali Samuel; Green Thomas A; Kumar Arvind; Chakravarty Sumana; Self David W; Nestler Eric J
Increased impulsivity during withdrawal from cocaine self-administration: role for DeltaFosB in the orbitofrontal cortex.
Cerebral cortex (New York, N.Y. : 1991) 2009;19(2):435-44.
2009: Ulery-Reynolds P G; Castillo M A; Vialou V; Russo S J; Nestler E J
Phosphorylation of DeltaFosB mediates its stability in vivo.
Neuroscience 2009;158(2):369-72.
2009: Renthal William; Nestler Eric J
Chromatin regulation in drug addiction and depression.
Dialogues in clinical neuroscience 2009;11(3):257-68.
2009: Nestler Eric J
Effects of drugs of abuse on the brain during development. Foreword.
Developmental neuroscience 2009;31(1-2):6.
2009: Russo Scott J; Mazei-Robison Michelle S; Ables Jessica L; Nestler Eric J
Neurotrophic factors and structural plasticity in addiction.
Neuropharmacology 2009;56 Suppl 1():73-82.
2008: Borrelli Emiliana; Nestler Eric J; Allis C David; Sassone-Corsi Paolo
Decoding the epigenetic language of neuronal plasticity.
Neuron 2008;60(6):961-74.
2008: Teegarden Sarah L; Nestler Eric J; Bale Tracy L
Delta FosB-mediated alterations in dopamine signaling are normalized by a palatable high-fat diet.
Biological psychiatry 2008;64(11):941-50.
2008: Jiang Yan; Langley Brett; Lubin Farah D; Renthal William; Wood Marcelo A; Yasui Dag H; Kumar Arvind; Nestler Eric J; Akbarian Schahram; Beckel-Mitchener Andrea C
Epigenetics in the nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(46):11753-9.
2008: Krishnan Vaishnav; Nestler Eric J
The molecular neurobiology of depression.
Nature 2008;455(7215):894-902.
2008: Wallace Deanna L; Vialou Vincent; Rios Loretta; Carle-Florence Tiffany L; Chakravarty Sumana; Kumar Arvind; Graham Danielle L; Green Thomas A; Kirk Anne; Iñiguez Sergio D; Perrotti Linda I; Barrot Michel; DiLeone Ralph J; Nestler Eric J; Bolaños-Guzmán Carlos A
The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(41):10272-7.
2008: Iñiguez Sergio D; Warren Brandon L; Neve Rachael L; Nestler Eric J; Russo Scott J; Bolaños-Guzmán Carlos A
Insulin receptor substrate-2 in the ventral tegmental area regulates behavioral responses to cocaine.
Behavioral neuroscience 2008;122(5):1172-7.
2008: Kim Kyoung-Shim; Lee Ko-Woon; Baek In-Sun; Lim Chae-Moon; Krishnan Vaishnav; Lee Ja-Kyeong; Nestler Eric J; Han Pyung-Lim
Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior.
Journal of neurochemistry 2008;107(1):105-15.
2008: Nestler Eric J
Review. Transcriptional mechanisms of addiction: role of DeltaFosB.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1507):3245-55.
2008: Krishnan Vaishnav; Han Ming-Hu; Mazei-Robison Michelle; Iñiguez Sergio D; Ables Jessica L; Vialou Vincent; Berton Olivier; Ghose Subroto; Covington Herbert E; Wiley Matthew D; Henderson Ross P; Neve Rachael L; Eisch Amelia J; Tamminga Carol A; Russo Scott J; Bolaños Carlos A; Nestler Eric J
AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli.
Biological psychiatry 2008;64(8):691-700.
2008: Potenza Marc N; Brodkin Edward S; Yang Bao-Zhu; Birnbaum Shari G; Nestler Eric J; Gelernter Joel
Quantitative trait locus analysis identifies rat genomic regions related to amphetamine-induced locomotion and Galpha(i3) levels in nucleus accumbens.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(11):2735-46.
2008: Krishnan Vaishnav; Berton Olivier; Nestler Eric
The use of animal models in psychiatric research and treatment.
The American journal of psychiatry 2008;165(9):1109.
2008: Pulipparacharuvil Suprabha; Renthal William; Hale Carly F; Taniguchi Makoto; Xiao Guanghua; Kumar Arvind; Russo Scott J; Sikder Devanjan; Dewey Colleen M; Davis Maya M; Greengard Paul; Nairn Angus C; Nestler Eric J; Cowan Christopher W
Cocaine regulates MEF2 to control synaptic and behavioral plasticity.
Neuron 2008;59(4):621-33.
2008: Renthal William; Nestler Eric J
Epigenetic mechanisms in drug addiction.
Trends in molecular medicine 2008;14(8):341-50.
2008: Krishnan Vaishnav; Graham Ami; Mazei-Robison Michelle S; Lagace Diane C; Kim Kyoung-Shim; Birnbaum Shari; Eisch Amelia J; Han Pyung-Lim; Storm Daniel R; Zachariou Venetia; Nestler Eric J
Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting.
Biological psychiatry 2008;64(4):336-43.
2008: Renthal William; Carle Tiffany L; Maze Ian; Covington Herbert E; Truong Hoang-Trang; Alibhai Imran; Kumar Arvind; Montgomery Rusty L; Olson Eric N; Nestler Eric J
Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(29):7344-9.
2008: Lutter Michael; Sakata Ichiro; Osborne-Lawrence Sherri; Rovinsky Sherry A; Anderson Jason G; Jung Saendy; Birnbaum Shari; Yanagisawa Masashi; Elmquist Joel K; Nestler Eric J; Zigman Jeffrey M
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress.
Nature neuroscience 2008;11(7):752-3.
2008: Zachariou Venetia; Liu Rongjian; LaPlant Quincey; Xiao Guanghua; Renthal William; Chan Guy C; Storm Daniel R; Aghajanian George; Nestler Eric J
Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies.
Biological psychiatry 2008;63(11):1013-21.
2008: Perrotti L I; Weaver R R; Robison B; Renthal W; Maze I; Yazdani S; Elmore R G; Knapp D J; Selley D E; Martin B R; Sim-Selley L; Bachtell R K; Self D W; Nestler E J
Distinct patterns of DeltaFosB induction in brain by drugs of abuse.
Synapse (New York, N.Y.) 2008;62(5):358-69.
2008: Charlton Joanna J; Allen Patrick B; Psifogeorgou Kassi; Chakravarty Sumana; Gomes Ivone; Neve Rachael L; Devi Lakshmi A; Greengard Paul; Nestler Eric J; Zachariou Venetia
Multiple actions of spinophilin regulate mu opioid receptor function.
Neuron 2008;58(2):238-47.
2008: Krystal John H; Carter Cameron S; Geschwind Daniel; Manji Husseini K; March John S; Nestler Eric J; Zubieta Jon-Kar; Charney Dennis S; Goldman David; Gur Raquel E; Lieberman Jeffrey A; Roy-Byrne Peter; Rubinow David R; Anderson Stewart A; Barondes Samuel; Berman Karen F; Blair James; Braff David L; Brown E Sherwood; Calabrese Joseph R; Carlezon William A; Cook Edwin H; Davidson Richard J; Davis Michael; Desimone Robert; Drevets Wayne C; Duman Ronald S; Essock Susan M; Faraone Stephen V; Freedman Robert; Friston Karl J; Gelernter Joel; Geller Barbara; Gill Michael; Gould Elizabeth; Grace Anthony A; Grillon Christian; Gueorguieva Ralitza; Hariri Ahmad R; Innis Robert B; Jones Edward G; Kleinman Joel E; Koob George F; Krystal Andrew D; Leibenluft Ellen; Levinson Douglas F; Levitt Pat R; Lewis David A; Liberzon Israel; Lipska Barbara K; Marder Stephen R; Markou Athina; Mason Graeme F; McDougle Christopher J; McEwen Bruce S; McMahon Francis J; Meaney Michael J; Meltzer Herbert Y; Merikangas Kathleen R; Meyer-Lindenberg Andreas; Mirnics Károly; Monteggia Lisa M; Neumeister Alexander; O'Brien Charles P; Owen Michael J; Pine Daniel S; Rapoport Judith L; Rauch Scott L; Robbins Trevor W; Rosenbaum Jerrold F; Rosenberg David R; Ross Christopher A; Rush A John; Sackeim Harold A; Sanacora Gerard; Schatzberg Alan F; Shaham Yavin; Siever Larry J; Sunderland Trey; Tecott Laurence H; Thase Michael E; Todd Richard D; Weissman Myrna M; Yehuda Rachel; Yoshikawa Takeo; Young Elizabeth A; McCandless R
It is time to take a stand for medical research and against terrorism targeting medical scientists.
Biological psychiatry 2008;63(8):725-7.
2008: Lutter Michael; Krishnan Vaishnav; Russo Scott J; Jung Saendy; McClung Colleen A; Nestler Eric J
Orexin signaling mediates the antidepressant-like effect of calorie restriction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(12):3071-5.
2008: Green Thomas A; Alibhai Imran N; Unterberg Stephen; Neve Rachael L; Ghose Subroto; Tamminga Carol A; Nestler Eric J
Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(9):2025-32.
2008: Huang Yanhua H; Lin Ying; Brown Travis E; Han Ming-Hu; Saal Daniel B; Neve Rachael L; Zukin R Suzanne; Sorg Barbara A; Nestler Eric J; Malenka Robert C; Dong Yan
CREB modulates the functional output of nucleus accumbens neurons: a critical role of N-methyl-D-aspartate glutamate receptor (NMDAR) receptors.
The Journal of biological chemistry 2008;283(5):2751-60.
2008: Steiner Michel A; Marsicano Giovanni; Nestler Eric J; Holsboer Florian; Lutz Beat; Wotjak Carsten T
Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice.
Psychoneuroendocrinology 2008;33(1):54-67.
2008: McClung Colleen A; Nestler Eric J
Neuroplasticity mediated by altered gene expression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(1):3-17.
2007: Renthal William; Maze Ian; Krishnan Vaishnav; Covington Herbert E; Xiao Guanghua; Kumar Arvind; Russo Scott J; Graham Ami; Tsankova Nadia; Kippin Tod E; Kerstetter Kerry A; Neve Rachael L; Haggarty Stephen J; McKinsey Timothy A; Bassel-Duby Rhonda; Olson Eric N; Nestler Eric J
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.
Neuron 2007;56(3):517-29.
2007: Krishnan Vaishnav; Han Ming-Hu; Graham Danielle L; Berton Olivier; Renthal William; Russo Scott J; Laplant Quincey; Graham Ami; Lutter Michael; Lagace Diane C; Ghose Subroto; Reister Robin; Tannous Paul; Green Thomas A; Neve Rachael L; Chakravarty Sumana; Kumar Arvind; Eisch Amelia J; Self David W; Lee Francis S; Tamminga Carol A; Cooper Donald C; Gershenfeld Howard K; Nestler Eric J
Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions.
Cell 2007;131(2):391-404.
2007: Winstanley Catharine A; LaPlant Quincey; Theobald David E H; Green Thomas A; Bachtell Ryan K; Perrotti Linda I; DiLeone Ralph J; Russo Scott J; Garth William J; Self David W; Nestler Eric J
DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(39):10497-507.
2007: Berton Olivier; Covington Herbert E; Ebner Karl; Tsankova Nadia M; Carle Tiffany L; Ulery Paula; Bhonsle Akshay; Barrot Michel; Krishnan Vaishnav; Singewald Georg M; Singewald Nicolas; Birnbaum Shari; Neve Rachael L; Nestler Eric J
Induction of deltaFosB in the periaqueductal gray by stress promotes active coping responses.
Neuron 2007;55(2):289-300.
2007: Jorissen Helena J M M; Ulery Paula G; Henry Lisa; Gourneni Sreekrishna; Nestler Eric J; Rudenko Gabby
Dimerization and DNA-binding properties of the transcription factor DeltaFosB.
Biochemistry 2007;46(28):8360-72.
2007: Wolf Daniel H; Nestler Eric J; Russell David S
Regulation of neuronal PLCgamma by chronic morphine.
Brain research 2007;1156():9-20.
2007: Carle Tiffany L; Ohnishi Yoshinori N; Ohnishi Yoko H; Alibhai Imran N; Wilkinson Matthew B; Kumar Arvind; Nestler Eric J
Proteasome-dependent and -independent mechanisms for FosB destabilization: identification of FosB degron domains and implications for DeltaFosB stability.
The European journal of neuroscience 2007;25(10):3009-19.
2007: Tsankova Nadia; Renthal William; Kumar Arvind; Nestler Eric J
Epigenetic regulation in psychiatric disorders.
Nature reviews. Neuroscience 2007;8(5):355-67.
2007: Roybal Kole; Theobold David; Graham Ami; DiNieri Jennifer A; Russo Scott J; Krishnan Vaishnav; Chakravarty Sumana; Peevey Joseph; Oehrlein Nathan; Birnbaum Shari; Vitaterna Martha H; Orsulak Paul; Takahashi Joseph S; Nestler Eric J; Carlezon William A; McClung Colleen A
Mania-like behavior induced by disruption of CLOCK.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6406-11.
2007: Alibhai Imran N; Green Thomas A; Potashkin Judith A; Nestler Eric J
Regulation of fosB and DeltafosB mRNA expression: in vivo and in vitro studies.
Brain research 2007;1143():22-33.
2007: Taylor Jane R; Lynch Wendy J; Sanchez Hayde; Olausson Peter; Nestler Eric J; Bibb James A
Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4147-52.
2007: Olson Valerie G; Green Thomas A; Neve Rachael L; Nestler Eric J
Regulation of morphine reward and feeding by CREB in the lateral hypothalamus.
Synapse (New York, N.Y.) 2007;61(2):110-3.
2007: Olson Valerie G; Nestler Eric J
Topographical organization of GABAergic neurons within the ventral tegmental area of the rat.
Synapse (New York, N.Y.) 2007;61(2):87-95.
2007: Ulery Paula G; Nestler Eric J
Regulation of DeltaFosB transcriptional activity by Ser27 phosphorylation.
The European journal of neuroscience 2007;25(1):224-30.
2007: Russo Scott J; Bolanos Carlos A; Theobald David E; DeCarolis Nathan A; Renthal William; Kumar Arvind; Winstanley Catharine A; Renthal Nora E; Wiley Matthew D; Self David W; Russell David S; Neve Rachael L; Eisch Amelia J; Nestler Eric J
IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates.
Nature neuroscience 2007;10(1):93-9.
2007: Monteggia Lisa M; Luikart Bryan; Barrot Michel; Theobold David; Malkovska Irena; Nef Serge; Parada Luis F; Nestler Eric J
Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors.
Biological psychiatry 2007;61(2):187-97.
2006: Olausson Peter; Jentsch J David; Tronson Natalie; Neve Rachel L; Nestler Eric J; Taylor Jane R
DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(36):9196-204.
2006: Green Thomas A; Alibhai Imran N; Hommel Jonathan D; DiLeone Ralph J; Kumar Arvind; Theobald David E; Neve Rachael L; Nestler Eric J
Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(32):8235-42.
2006: Allen P B; Zachariou V; Svenningsson P; Lepore A C; Centonze D; Costa C; Rossi S; Bender G; Chen G; Feng J; Snyder G L; Bernardi G; Nestler E J; Yan Z; Calabresi P; Greengard P
Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity.
Neuroscience 2006;140(3):897-911.
2006: Nestler Eric J; Carlezon William A
The mesolimbic dopamine reward circuit in depression.
Biological psychiatry 2006;59(12):1151-9.
2006: Ulery Paula G; Rudenko Gabby; Nestler Eric J
Regulation of DeltaFosB stability by phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(19):5131-42.
2006: Han Ming-Hu; Bolaños Carlos A; Green Thomas A; Olson Valerie G; Neve Rachael L; Liu Rong-Jian; Aghajanian George K; Nestler Eric J
Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(17):4624-9.
2006: Dong Yan; Green Thomas; Saal Daniel; Marie Helene; Neve Rachael; Nestler Eric J; Malenka Robert C
CREB modulates excitability of nucleus accumbens neurons.
Nature neuroscience 2006;9(4):475-7.
2006: Tsankova Nadia M; Berton Olivier; Renthal William; Kumar Arvind; Neve Rachel L; Nestler Eric J
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action.
Nature neuroscience 2006;9(4):519-25.
2006: Kim Kyoung-Shim; Lee Ko-Woon; Lee Kang-Woo; Im Joo-Young; Yoo Ji Yeoun; Kim Seung-Woo; Lee Ja-Kyeong; Nestler Eric J; Han Pyung-Lim
Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3908-13.
2006: Zachariou Venetia; Sgambato-Faure Véronique; Sasaki Teresa; Svenningsson Per; Berton Olivier; Fienberg Allen A; Nairn Angus C; Greengard Paul; Nestler Eric J
Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine action.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(3):555-62.
2006: Berton Olivier; McClung Colleen A; Dileone Ralph J; Krishnan Vaishnav; Renthal William; Russo Scott J; Graham Danielle; Tsankova Nadia M; Bolanos Carlos A; Rios Maribel; Monteggia Lisa M; Self David W; Nestler Eric J
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress.
Science (New York, N.Y.) 2006;311(5762):864-8.
2006: Tamminga Carol A; Nestler Eric J
Pathological gambling: focusing on the addiction, not the activity.
The American journal of psychiatry 2006;163(2):180-1.
2006: Berton Olivier; Nestler Eric J
New approaches to antidepressant drug discovery: beyond monoamines.
Nature reviews. Neuroscience 2006;7(2):137-51.
2006: Zachariou Venetia; Bolanos Carlos A; Selley Dana E; Theobald David; Cassidy Michael P; Kelz Max B; Shaw-Lutchman Tamara; Berton Olivier; Sim-Selley Laura J; Dileone Ralph J; Kumar Arvind; Nestler Eric J
An essential role for DeltaFosB in the nucleus accumbens in morphine action.
Nature neuroscience 2006;9(2):205-11.
2006: Hyman Steven E; Malenka Robert C; Nestler Eric J
Neural mechanisms of addiction: the role of reward-related learning and memory.
Annual review of neuroscience 2006;29():565-98.
2005: Nestler Eric J
The neurobiology of cocaine addiction.
Science & practice perspectives / a publication of the National Institute on Drug Abuse, National Institutes of Health 2005;3(1):4-10.
2005: Colvis Christine M; Pollock Jonathan D; Goodman Richard H; Impey Soren; Dunn John; Mandel Gail; Champagne Frances A; Mayford Mark; Korzus Edward; Kumar Arvind; Renthal William; Theobald David E H; Nestler Eric J
Epigenetic mechanisms and gene networks in the nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(45):10379-89.
2005: Nestler Eric J
Is there a common molecular pathway for addiction?
Nature neuroscience 2005;8(11):1445-9.
2005: Kumar Arvind; Choi Kwang-Ho; Renthal William; Tsankova Nadia M; Theobald David E H; Truong Hoang-Trang; Russo Scott J; Laplant Quincey; Sasaki Teresa S; Whistler Kimberly N; Neve Rachael L; Self David W; Nestler Eric J
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum.
Neuron 2005;48(2):303-14.
2005: Neve Rachael L; Neve Kim A; Nestler Eric J; Carlezon William A
Use of herpes virus amplicon vectors to study brain disorders.
BioTechniques 2005;39(3):381-91.
2005: Carlezon William A; Duman Ronald S; Nestler Eric J
The many faces of CREB.
Trends in neurosciences 2005;28(8):436-45.
2005: McClung Colleen A; Nestler Eric J; Zachariou Venetia
Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(25):6005-15.
2005: McClung Colleen A; Sidiropoulou Kyriaki; Vitaterna Martha; Takahashi Joseph S; White Francis J; Cooper Donald C; Nestler Eric J
Regulation of dopaminergic transmission and cocaine reward by the Clock gene.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9377-81.
2005: Olson Valerie G; Zabetian Cyrus P; Bolanos Carlos A; Edwards Scott; Barrot Michel; Eisch Amelia J; Hughes Thomas; Self David W; Neve Rachael L; Nestler Eric J
Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(23):5553-62.
2005: Barrot Michel; Wallace Deanna L; Bolaños Carlos A; Graham Danielle L; Perrotti Linda I; Neve Rachael L; Chambliss Heather; Yin Jerry C; Nestler Eric J
Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8357-62.
2005: Bolaños Carlos A; Neve Rachael L; Nestler Eric J
Phospholipase C gamma in distinct regions of the ventral tegmental area differentially regulates morphine-induced locomotor activity.
Synapse (New York, N.Y.) 2005;56(3):166-9.
2005: Perrotti Linda I; Bolaños Carlos A; Choi Kwang-Ho; Russo Scott J; Edwards Scott; Ulery Paula G; Wallace Deanna L; Self David W; Nestler Eric J; Barrot Michel
DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment.
The European journal of neuroscience 2005;21(10):2817-24.
2005: Hsu Richard; Taylor Jane R; Newton Samuel S; Alvaro John D; Haile Colin; Han G; Hruby Victor J; Nestler Eric J; Duman Ronald S
Blockade of melanocortin transmission inhibits cocaine reward.
The European journal of neuroscience 2005;21(8):2233-42.
2005: Lucas Guillaume; Compan Valérie; Charnay Yves; Neve Rachael L; Nestler Eric J; Bockaert Joël; Barrot Michel; Debonnel Guy
Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists.
Biological psychiatry 2005;57(8):918-25.
2005: Georgescu Dan; Sears Robert M; Hommel Jonathan D; Barrot Michel; Bolaños Carlos A; Marsh Donald J; Bednarek Maria A; Bibb James A; Maratos-Flier Eleftheria; Nestler Eric J; DiLeone Ralph J
The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(11):2933-40.
2004: McClung Colleen A; Ulery Paula G; Perrotti Linda I; Zachariou Venetia; Berton Olivier; Nestler Eric J
DeltaFosB: a molecular switch for long-term adaptation in the brain.
Brain research. Molecular brain research 2004;132(2):146-54.
2004: Perrotti Linda I; Hadeishi Yuki; Ulery Paula G; Barrot Michel; Monteggia Lisa; Duman Ronald S; Nestler Eric J
Induction of deltaFosB in reward-related brain structures after chronic stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(47):10594-602.
2004: Monteggia Lisa M; Barrot Michel; Powell Craig M; Berton Olivier; Galanis Victor; Gemelli Terry; Meuth Sven; Nagy Andreas; Greene Robert W; Nestler Eric J
Essential role of brain-derived neurotrophic factor in adult hippocampal function.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10827-32.
2004: Tsankova Nadia M; Kumar Arvind; Nestler Eric J
Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(24):5603-10.
2004: Tecott Laurence H; Nestler Eric J
Neurobehavioral assessment in the information age.
Nature neuroscience 2004;7(5):462-6.
2004: Powell Craig M; Schoch Susanne; Monteggia Lisa; Barrot Michel; Matos Maria F; Feldmann Nicole; Südhof Thomas C; Nestler Eric J
The presynaptic active zone protein RIM1alpha is critical for normal learning and memory.
Neuron 2004;42(1):143-53.
2004: Nestler Eric J
Historical review: Molecular and cellular mechanisms of opiate and cocaine addiction.
Trends in pharmacological sciences 2004;25(4):210-8.
2004: Potenza Marc N; Brodkin Edward S; Joe Bina; Luo Xingguang; Remmers Elaine F; Wilder Ronald L; Nestler Eric J; Gelernter Joel
Genomic regions controlling corticosterone levels in rats.
Biological psychiatry 2004;55(6):634-41.
2004: Nestler Eric J; Malenka Robert C
The addicted brain.
Scientific American 2004;290(3):78-85.
2004: Chen Jingshan; Newton Samuel S; Zeng Ling; Adams David H; Dow Anthoni L; Madsen Torsten M; Nestler Eric J; Duman Ronald S
Downregulation of the CCAAT-enhancer binding protein beta in deltaFosB transgenic mice and by electroconvulsive seizures.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(1):23-31.
2004: Nestler Eric J
Molecular mechanisms of drug addiction.
Neuropharmacology 2004;47 Suppl 1():24-32.
2004: Bolaños Carlos A; Nestler Eric J
Neurotrophic mechanisms in drug addiction.
Neuromolecular medicine 2004;5(1):69-83.
2004: Chao Jennifer; Nestler Eric J
Molecular neurobiology of drug addiction.
Annual review of medicine 2004;55():113-32.
2003: Bolaños Carlos A; Barrot Michel; Berton Olivier; Wallace-Black Deanna; Nestler Eric J
Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood.
Biological psychiatry 2003;54(12):1317-29.
2003: Eisch Amelia J; Bolaños Carlos A; de Wit Joris; Simonak Ryan D; Pudiak Cindy M; Barrot Michel; Verhaagen Joost; Nestler Eric J
Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression.
Biological psychiatry 2003;54(10):994-1005.
2003: Zachariou Venetia; Georgescu Dan; Sanchez Nick; Rahman Zia; DiLeone Ralph; Berton Olivier; Neve Rachael L; Sim-Selley Laura J; Selley Dana E; Gold Stephen J; Nestler Eric J
Essential role for RGS9 in opiate action.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13656-61.
2003: McClung Colleen A; Nestler Eric J
Regulation of gene expression and cocaine reward by CREB and DeltaFosB.
Nature neuroscience 2003;6(11):1208-15.
2003: Nestler Eric J
Obituary: Patricia S. Goldman-Rakic (1937-2003).
Nature 2003;425(6957):471.
2003: Bolaños Carlos A; Perrotti Linda I; Edwards Scott; Eisch Amelia J; Barrot Michel; Olson Valerie G; Russell David S; Neve Rachael L; Nestler Eric J
Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(20):7569-76.
2003: Rahman Zia; Schwarz Johannes; Gold Stephen J; Zachariou Venetia; Wein Marc N; Choi Kwang Ho; Kovoor Abraham; Chen Ching Kang; DiLeone Ralph J; Schwarz Sigrid C; Selley Dana E; Sim-Selley Laura J; Barrot Michel; Luedtke Robert R; Self David; Neve Rachael L; Lester Henry A; Simon Melvin I; Nestler Eric J
RGS9 modulates dopamine signaling in the basal ganglia.
Neuron 2003;38(6):941-52.
2003: DiLeone Ralph J; Georgescu Dan; Nestler Eric J
Lateral hypothalamic neuropeptides in reward and drug addiction.
Life sciences 2003;73(6):759-68.
2003: Haberstock-Debic Helena; Wein Marc; Barrot Michel; Colago Eric E O; Rahman Zia; Neve Rachael L; Pickel Virginia M; Nestler Eric J; von Zastrow Mark; Svingos Adena L
Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(10):4324-32.
2003: Georgescu Dan; Zachariou Venetia; Barrot Michel; Mieda Michihiro; Willie Jon T; Eisch Amelia J; Yanagisawa Masashi; Nestler Eric J; DiLeone Ralph J
Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(8):3106-11.
2003: Peakman M-C; Colby C; Perrotti L I; Tekumalla P; Carle T; Ulery P; Chao J; Duman C; Steffen C; Monteggia L; Allen M R; Stock J L; Duman R S; McNeish J D; Barrot M; Self D W; Nestler E J; Schaeffer E
Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine.
Brain research 2003;970(1-2):73-86.
2003: Shaw-Lutchman Tamara Z; Impey Soren; Storm Daniel; Nestler Eric J
Regulation of CRE-mediated transcription in mouse brain by amphetamine.
Synapse (New York, N.Y.) 2003;48(1):10-7.
2003: Colby Christina R; Whisler Kim; Steffen Cathy; Nestler Eric J; Self David W
Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(6):2488-93.
2003: Gold Stephen J; Han Ming-Hu; Herman Amy E; Ni Yan G; Pudiak Cindy M; Aghajanian George K; Liu Rong-Jian; Potts Bryan W; Mumby Susanne M; Nestler Eric J
Regulation of RGS proteins by chronic morphine in rat locus coeruleus.
The European journal of neuroscience 2003;17(5):971-80.
2003: Norrholm S D; Bibb J A; Nestler E J; Ouimet C C; Taylor J R; Greengard P
Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5.
Neuroscience 2003;116(1):19-22.
2002: Newton Samuel S; Thome Johannes; Wallace Tanya L; Shirayama Yukihikko; Schlesinger Lee; Sakai Norio; Chen Jingshan; Neve Rachael; Nestler Eric J; Duman Ronald S
Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(24):10883-90.
2002: Carlezon William A; Nestler Eric J
Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?
Trends in neurosciences 2002;25(12):610-5.
2002: Nestler Eric J
Common molecular and cellular substrates of addiction and memory.
Neurobiology of learning and memory 2002;78(3):637-47.
2002: Nestler Eric J
From neurobiology to treatment: progress against addiction.
Nature neuroscience 2002;5 Suppl():1076-9.
2002: Chao Jennifer R; Ni Yan G; Bolaños Carlos A; Rahman Zia; DiLeone Ralph J; Nestler Eric J
Characterization of the mouse adenylyl cyclase type VIII gene promoter: regulation by cAMP and CREB.
The European journal of neuroscience 2002;16(7):1284-94.
2002: Nestler Eric J; Gould Elizabeth; Manji Husseini; Buncan Maja; Duman Ronald S; Greshenfeld Howard K; Hen Ren; Koester Susan; Lederhendler Israel; Meaney Michael; Robbins Trevor; Winsky Lois; Zalcman Steve
Preclinical models: status of basic research in depression.
Biological psychiatry 2002;52(6):503-28.
2002: Werme Martin; Messer Chad; Olson Lars; Gilden Lauren; Thorén Peter; Nestler Eric J; Brené Stefan
Delta FosB regulates wheel running.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):8133-8.
2002: Gold Stephen J; Heifets Boris D; Pudiak Cindy M; Potts Bryan W; Nestler Eric J
Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures.
Journal of neurochemistry 2002;82(4):828-38.
2002: Barrot Michel; Olivier Jocelien D A; Perrotti Linda I; DiLeone Ralph J; Berton Olivier; Eisch Amelia J; Impey Soren; Storm Daniel R; Neve Rachael L; Yin Jerry C; Zachariou Venetia; Nestler Eric J
CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11435-40.
2002: Jentsch J David; Olausson Peter; Nestler Eric J; Taylor Jane R
Stimulation of protein kinase a activity in the rat amygdala enhances reward-related learning.
Biological psychiatry 2002;52(2):111-8.
2002: Chen Jingshan; Kelz Max B; Zeng Guoqi; Steffen Cathy; Shockett Penny E; Terwilliger Gordon; Schatz David G; Nestler Eric J
Inducible, reversible hair loss in transgenic mice.
Transgenic research 2002;11(3):241-7.
2002: Sakai Norio; Thome Johannes; Newton Samuel S; Chen Jingshan; Kelz Max B; Steffen Cathy; Nestler Eric J; Duman Ronald S
Inducible and brain region-specific CREB transgenic mice.
Molecular pharmacology 2002;61(6):1453-64.
2002: Akbarian Schahram; Rios Maribel; Liu Rong-Jian; Gold Stephen J; Fong Hiu-Fai; Zeiler Steve; Coppola Vincenzo; Tessarollo Lino; Jones Kevin R; Nestler Eric J; Aghajanian George K; Jaenisch Rudolf
Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(10):4153-62.
2002: Nakagawa Shin; Kim Ji-Eun; Lee Rena; Malberg Jessica E; Chen Jingshan; Steffen Cathy; Zhang Ya-Jun; Nestler Eric J; Duman Ronald S
Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(9):3673-82.
2002: Shaw-Lutchman Tamara Z; Barrot Michel; Wallace Tanya; Gilden Lauren; Zachariou Venetia; Impey Soren; Duman Ronald S; Storm Daniel; Nestler Eric J
Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(9):3663-72.
2002: Nestler Eric J; Barrot Michel; DiLeone Ralph J; Eisch Amelia J; Gold Stephen J; Monteggia Lisa M
Neurobiology of depression.
Neuron 2002;34(1):13-25.
2002: Mower Amanda F; Liao David S; Nestler Eric J; Neve Rachael L; Ramoa Ary S
cAMP/Ca2+ response element-binding protein function is essential for ocular dominance plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(6):2237-45.
2002: Sims N A; Sabatakos G; Chen J-S; Kelz M B; Nestler E J; Baron R
Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass.
Bone 2002;30(1):32-9.
2001: Brãuer A U; Savaskan N E; Kole M H; Plaschke M; Monteggia L M; Nestler E J; Simburger E; Deisz R A; Ninnemann O; Nitsch R
Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2689-701.
2001: Tekumalla P K; Calon F; Rahman Z; Birdi S; Rajput A H; Hornykiewicz O; Di Paolo T; Bédard P J; Nestler E J
Elevated levels of DeltaFosB and RGS9 in striatum in Parkinson's disease.
Biological psychiatry 2001;50(10):813-6.
2001: Nestler E J
Psychogenomics: opportunities for understanding addiction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(21):8324-7.
2001: Ang E; Chen J; Zagouras P; Magna H; Holland J; Schaeffer E; Nestler E J
Induction of nuclear factor-kappaB in nucleus accumbens by chronic cocaine administration.
Journal of neurochemistry 2001;79(1):221-4.
2001: Nestler E J; Barrot M; Self D W
DeltaFosB: a sustained molecular switch for addiction.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11042-6.
2001: Pliakas A M; Carlson R R; Neve R L; Konradi C; Nestler E J; Carlezon W A
Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(18):7397-403.
2001: Akbarian S; Bates B; Liu R J; Skirboll S L; Pejchal T; Coppola V; Sun L D; Fan G; Kucera J; Wilson M A; Tessarollo L; Kosofsky B E; Taylor J R; Bothwell M; Nestler E J; Aghajanian G K; Jaenisch R
Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal.
Molecular psychiatry 2001;6(5):593-604.
2001: Haile C N; Hiroi N; Nestler E J; Kosten T A
Differential behavioral responses to cocaine are associated with dynamics of mesolimbic dopamine proteins in Lewis and Fischer 344 rats.
Synapse (New York, N.Y.) 2001;41(3):179-90.
2001: Nestler E J
Neurobiology. Total recall-the memory of addiction.
Science (New York, N.Y.) 2001;292(5525):2266-7.
2001: Hwang C K; D'Souza U M; Eisch A J; Yajima S; Lammers C H; Yang Y; Lee S H; Kim Y M; Nestler E J; Mouradian M M
Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7558-63.
2001: Josselyn S A; Shi C; Carlezon W A; Neve R L; Nestler E J; Davis M
Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(7):2404-12.
2001: Bibb J A; Chen J; Taylor J R; Svenningsson P; Nishi A; Snyder G L; Yan Z; Sagawa Z K; Ouimet C C; Nairn A C; Nestler E J; Greengard P
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.
Nature 2001;410(6826):376-80.
2001: Nestler E J
Molecular basis of long-term plasticity underlying addiction.
Nature reviews. Neuroscience 2001;2(2):119-28.
2001: Nestler E J; Landsman D
Learning about addiction from the genome.
Nature 2001;409(6822):834-5.
2001: Chen A C; Eisch A J; Sakai N; Takahashi M; Nestler E J; Duman R S
Regulation of GFRalpha-1 and GFRalpha-2 mRNAs in rat brain by electroconvulsive seizure.
Synapse (New York, N.Y.) 2001;39(1):42-50.
2001: Nestler E J
Molecular neurobiology of addiction.
The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions 2001;10(3):201-17.
2000: Kelz M B; Nestler E J
deltaFosB: a molecular switch underlying long-term neural plasticity.
Current opinion in neurology 2000;13(6):715-20.
2000: Malberg J E; Eisch A J; Nestler E J; Duman R S
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(24):9104-10.
2000: Chen J; Zhang Y; Kelz M B; Steffen C; Ang E S; Zeng L; Nestler E J
Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: role of [Delta]FosB.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(24):8965-71.
2000: Nestler E J
Genes and addiction.
Nature genetics 2000;26(3):277-81.
2000: Kelz M B; Kuszak J R; Yang Y; Ma W; Steffen C; Al-Ghoul K; Zhang Y J; Chen J; Nestler E J; Spector A
DeltaFosB-induced cataract.
Investigative ophthalmology & visual science 2000;41(11):3523-38.
2000: Monteggia L M; Eisch A J; Tang M D; Kaczmarek L K; Nestler E J
Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain.
Brain research. Molecular brain research 2000;81(1-2):129-39.
2000: Sabatakos G; Sims N A; Chen J; Aoki K; Kelz M B; Amling M; Bouali Y; Mukhopadhyay K; Ford K; Nestler E J; Baron R
Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis.
Nature medicine 2000;6(9):985-90.
2000: Carlezon W A; Kosten T A; Nestler E J
Behavioral interactions caused by combined administration of morphine and MK-801 in rats.
Psychopharmacology 2000;151(2-3):261-72.
2000: Nankova B B; Rivkin M; Kelz M; Nestler E J; Sabban E L
Fos-related antigen 2: potential mediator of the transcriptional activation in rat adrenal medulla evoked by repeated immobilization stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(15):5647-53.
2000: Eisch A J; Barrot M; Schad C A; Self D W; Nestler E J
Opiates inhibit neurogenesis in the adult rat hippocampus.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7579-84.
2000: Brené S; Messer C; Okado H; Hartley M; Heinemann S F; Nestler E J
Regulation of GluR2 promoter activity by neurotrophic factors via a neuron-restrictive silencer element.
The European journal of neuroscience 2000;12(5):1525-33.
2000: Messer C J; Eisch A J; Carlezon W A; Whisler K; Shen L; Wolf D H; Westphal H; Collins F; Russell D S; Nestler E J
Role for GDNF in biochemical and behavioral adaptations to drugs of abuse.
Neuron 2000;26(1):247-57.
2000: Carlezon W A; Haile C N; Coppersmith R; Hayashi Y; Malinow R; Neve R L; Nestler E J
Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(5):RC62.
2000: Carlezon W A; Nestler E J; Neve R L
Herpes simplex virus-mediated gene transfer as a tool for neuropsychiatric research.
Critical reviews in neurobiology 2000;14(1):47-67.
2000: Jolas T; Nestler E J; Aghajanian G K
Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an up-regulation of the cyclic AMP pathway.
Neuroscience 2000;95(2):433-43.
1999: Messer C J; Son J H; Joh T H; Beck K D; Nestler E J
Regulation of tyrosine hyroxylase gene transcription in ventral midbrain by glial cell line-derived neurotrophic factor.
Synapse (New York, N.Y.) 1999;34(3):241-3.
1999: Nestler E J; Alreja M; Aghajanian G K
Molecular control of locus coeruleus neurotransmission.
Biological psychiatry 1999;46(9):1131-9.
1999: Potenza M N; Gold S J; Roby-Shemkowitz A; Lerner M R; Nestler E J
Effects of regulators of G protein-signaling proteins on the functional response of the mu-opioid receptor in a melanophore-based assay.
The Journal of pharmacology and experimental therapeutics 1999;291(2):482-91.
1999: Wolf D H; Numan S; Nestler E J; Russell D S
Regulation of phospholipase Cgamma in the mesolimbic dopamine system by chronic morphine administration.
Journal of neurochemistry 1999;73(4):1520-8.
1999: Kelz M B; Chen J; Carlezon W A; Whisler K; Gilden L; Beckmann A M; Steffen C; Zhang Y J; Marotti L; Self D W; Tkatch T; Baranauskas G; Surmeier D J; Neve R L; Duman R S; Picciotto M R; Nestler E J
Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine.
Nature 1999;401(6750):272-6.
1999: Atkins J B; Chlan-Fourney J; Nye H E; Hiroi N; Carlezon W A; Nestler E J
Region-specific induction of deltaFosB by repeated administration of typical versus atypical antipsychotic drugs.
Synapse (New York, N.Y.) 1999;33(2):118-28.
1999: Nestler E J; Kelz M B; Chen J
DeltaFosB: a molecular mediator of long-term neural and behavioral plasticity.
Brain research 1999;835(1):10-7.
1999: Charney D S; Innis R B; Nestler E J; Davis K L; Nemeroff C B; Weinberger D R
Increasing public trust and confidence in psychiatric research.
Biological psychiatry 1999;46(1):1-2.
1999: Horger B A; Iyasere C A; Berhow M T; Messer C J; Nestler E J; Taylor J R
Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(10):4110-22.
1999: Ni Y G; Gold S J; Iredale P A; Terwilliger R Z; Duman R S; Nestler E J
Region-specific regulation of RGS4 (Regulator of G-protein-signaling protein type 4) in brain by stress and glucocorticoids: in vivo and in vitro studies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(10):3674-80.
1999: Hiroi N; Fienberg A A; Haile C N; Alburges M; Hanson G R; Greengard P; Nestler E J
Neuronal and behavioural abnormalities in striatal function in DARPP-32-mutant mice.
The European journal of neuroscience 1999;11(3):1114-8.
1999: Rahman Z; Gold S J; Potenza M N; Cowan C W; Ni Y G; He W; Wensel T G; Nestler E J
Cloning and characterization of RGS9-2: a striatal-enriched alternatively spliced product of the RGS9 gene.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(6):2016-26.
1999: Carlezon W A; Rasmussen K; Nestler E J
AMPA antagonist LY293558 blocks the development, without blocking the expression, of behavioral sensitization to morphine.
Synapse (New York, N.Y.) 1999;31(4):256-62.
1999: Eisch A J; Lammers C H; Yajima S; Mouradian M M; Nestler E J
In vivo regulation of glial cell line-derived neurotrophic factor-inducible transcription factor by kainic acid.
Neuroscience 1999;94(2):629-36.
1999: Brodkin E S; Kosten T A; Haile C N; Heninger G R; Carlezon W A; Jatlow P; Remmers E F; Wilder R L; Nestler E J
Dark Agouti and Fischer 344 rats: differential behavioral responses to morphine and biochemical differences in the ventral tegmental area.
Neuroscience 1999;88(4):1307-15.
1998: Carlezon W A; Thome J; Olson V G; Lane-Ladd S B; Brodkin E S; Hiroi N; Duman R S; Neve R L; Nestler E J
Regulation of cocaine reward by CREB.
Science (New York, N.Y.) 1998;282(5397):2272-5.
1998: Numan S; Lane-Ladd S B; Zhang L; Lundgren K H; Russell D S; Seroogy K B; Nestler E J
Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(24):10700-8.
1998: Boundy V A; Gold S J; Messer C J; Chen J; Son J H; Joh T H; Nestler E J
Regulation of tyrosine hydroxylase promoter activity by chronic morphine in TH9.0-LacZ transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(23):9989-95.
1998: Coven E; Ni Y; Widnell K L; Chen J; Walker W H; Habener J F; Nestler E J
Cell type-specific regulation of CREB gene expression: mutational analysis of CREB promoter activity.
Journal of neurochemistry 1998;71(5):1865-74.
1998: Nestler E J
Antidepressant treatments in the 21st century.
Biological psychiatry 1998;44(7):526-33.
1998: Brodkin E S; Carlezon W A; Haile C N; Kosten T A; Heninger G R; Nestler E J
Genetic analysis of behavioral, neuroendocrine, and biochemical parameters in inbred rodents: initial studies in Lewis and Fischer 344 rats and in A/J and C57BL/6J mice.
Brain research 1998;805(1-2):55-68.
1998: Chen J; Kelz M B; Zeng G; Sakai N; Steffen C; Shockett P E; Picciotto M R; Duman R S; Nestler E J
Transgenic animals with inducible, targeted gene expression in brain.
Molecular pharmacology 1998;54(3):495-503.
1998: Hiroi N; Marek G J; Brown J R; Ye H; Saudou F; Vaidya V A; Duman R S; Greenberg M E; Nestler E J
Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(17):6952-62.
1998: Boundy V A; Chen J; Nestler E J
Regulation of cAMP-dependent protein kinase subunit expression in CATH.a and SH-SY5Y cells.
The Journal of pharmacology and experimental therapeutics 1998;286(2):1058-65.
1998: Fienberg A A; Hiroi N; Mermelstein P G; Song W; Snyder G L; Nishi A; Cheramy A; O'Callaghan J P; Miller D B; Cole D G; Corbett R; Haile C N; Cooper D C; Onn S P; Grace A A; Ouimet C C; White F J; Hyman S E; Surmeier D J; Girault J; Nestler E J; Greengard P
DARPP-32: regulator of the efficacy of dopaminergic neurotransmission.
Science (New York, N.Y.) 1998;281(5378):838-42.
1998: Self D W; Nestler E J
Relapse to drug-seeking: neural and molecular mechanisms.
Drug and alcohol dependence 1998;51(1-2):49-60.
1998: Brené S; Messer C; Nestler E J
Expression of messenger RNAs encoding ionotropic glutamate receptors in rat brain: regulation by haloperidol.
Neuroscience 1998;84(3):813-23.
1998: Rocha B A; Scearce-Levie K; Lucas J J; Hiroi N; Castanon N; Crabbe J C; Nestler E J; Hen R
Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor.
Nature 1998;393(6681):175-8.
1998: Self D W; Genova L M; Hope B T; Barnhart W J; Spencer J J; Nestler E J
Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(5):1848-59.
1998: Nestler E J
Not-so-special K's. Let's limit K-05 awards.
Archives of general psychiatry 1998;55(1):15-6.
1998: Hiroi N; Nestler E J
Nuclear memory: gene transcription and behavior.
Advances in pharmacology (San Diego, Calif.) 1998;42():1037-41.
1997: Kosten T A; Miserendino M J; Haile C N; DeCaprio J L; Jatlow P I; Nestler E J
Acquisition and maintenance of intravenous cocaine self-administration in Lewis and Fischer inbred rat strains.
Brain research 1997;778(2):418-29.
1997: Punch L J; Self D W; Nestler E J; Taylor J R
Opposite modulation of opiate withdrawal behaviors on microinfusion of a protein kinase A inhibitor versus activator into the locus coeruleus or periaqueductal gray.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(21):8520-7.
1997: Nestler E J
Molecular mechanisms of opiate and cocaine addiction.
Current opinion in neurobiology 1997;7(5):713-9.
1997: Gold S J; Ni Y G; Dohlman H G; Nestler E J
Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):8024-37.
1997: Lane-Ladd S B; Pineda J; Boundy V A; Pfeuffer T; Krupinski J; Aghajanian G K; Nestler E J
CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7890-901.
1997: Nestler E J; Aghajanian G K
Molecular and cellular basis of addiction.
Science (New York, N.Y.) 1997;278(5335):58-63.
1997: Hiroi N; Brown J R; Haile C N; Ye H; Greenberg M E; Nestler E J
FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10397-402.
1997: Carlezon W A; Boundy V A; Haile C N; Lane S B; Kalb R G; Neve R L; Nestler E J
Sensitization to morphine induced by viral-mediated gene transfer.
Science (New York, N.Y.) 1997;277(5327):812-4.
1997: Duman R S; Heninger G R; Nestler E J
A molecular and cellular theory of depression.
Archives of general psychiatry 1997;54(7):597-606.
1997: Chen J; Kelz M B; Hope B T; Nakabeppu Y; Nestler E J
Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(13):4933-41.
1997: Malison R T; Price L H; Nestler E J; Heninger G R; Duman R S
Efficacy of papaverine addition for treatment-refractory major depression.
The American journal of psychiatry 1997;154(4):579-80.
1997: Nestler E J; Gao X M; Tamminga C A
Molecular biology, V. Immediate early genes.
The American journal of psychiatry 1997;154(3):312.
1997: Nestler E J
Schizophrenia. An emerging pathophysiology.
Nature 1997;385(6617):578-9.
1997: Nestler E J
Images in neuroscience. Molecular Biology, IV. Identifying DNA transcription factors.
The American journal of psychiatry 1997;154(2):146.
1997: Selley D E; Nestler E J; Breivogel C S; Childers S R
Opioid receptor-coupled G-proteins in rat locus coeruleus membranes: decrease in activity after chronic morphine treatment.
Brain research 1997;746(1-2):10-8.
1997: Duman R S; Nestler E J
Molecular biology, III. Tracking DNA: the Southern blot.
The American journal of psychiatry 1997;154(1):3.
1997: Charlton M E; Sweetnam P M; Fitzgerald L W; Terwilliger R Z; Nestler E J; Duman R S
Chronic ethanol administration regulates the expression of GABAA receptor alpha 1 and alpha 5 subunits in the ventral tegmental area and hippocampus.
Journal of neurochemistry 1997;68(1):121-7.
1997: Koob G F; Nestler E J
The neurobiology of drug addiction.
The Journal of neuropsychiatry and clinical neurosciences 1997;9(3):482-97.
1996: Berhow M T; Hiroi N; Kobierski L A; Hyman S E; Nestler E J
Influence of cocaine on the JAK-STAT pathway in the mesolimbic dopamine system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(24):8019-26.
1996: Kosten T A; DeCaprio J L; Nestler E J
Long-term haloperidol administration enhances and short-term administration attenuates the behavioral effects of cocaine in a place conditioning procedure.
Psychopharmacology 1996;128(3):304-12.
1996: Iredale P A; Terwilliger R; Widnell K L; Nestler E J; Duman R S
Differential regulation of corticotropin-releasing factor1 receptor expression by stress and agonist treatments in brain and cultured cells.
Molecular pharmacology 1996;50(5):1103-10.
1996: Sklair-Tavron L; Shi W X; Lane S B; Harris H W; Bunney B S; Nestler E J
Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):11202-7.
1996: Alvaro J D; Tatro J B; Quillan J M; Fogliano M; Eisenhard M; Lerner M R; Nestler E J; Duman R S
Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction.
Molecular pharmacology 1996;50(3):583-91.
1996: Berhow M T; Hiroi N; Nestler E J
Regulation of ERK (extracellular signal regulated kinase), part of the neurotrophin signal transduction cascade, in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(15):4707-15.
1996: Nestler E J; Berhow M T; Brodkin E S
Molecular mechanisms of drug addiction: adaptations in signal transduction pathways.
Molecular psychiatry 1996;1(3):190-9.
1996: Ortiz J; Fitzgerald L W; Lane S; Terwilliger R; Nestler E J
Biochemical adaptations in the mesolimbic dopamine system in response to repeated stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1996;14(6):443-52.
1996: Nestler E J
Under siege: The brain on opiates.
Neuron 1996;16(5):897-900.
1996: Krystal J H; Compere S; Nestler E J; Rasmussen K
Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats.
Physiology & behavior 1996;59(4-5):863-6.
1996: Widnell K L; Chen J S; Iredale P A; Walker W H; Duman R S; Habener J F; Nestler E J
Transcriptional regulation of CREB (cyclic AMP response element-binding protein) expression in CATH.a cells.
Journal of neurochemistry 1996;66(4):1770-3.
1996: Nye H E; Nestler E J
Induction of chronic Fos-related antigens in rat brain by chronic morphine administration.
Molecular pharmacology 1996;49(4):636-45.
1996: Nibuya M; Nestler E J; Duman R S
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(7):2365-72.
1996: Self D W; Barnhart W J; Lehman D A; Nestler E J
Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists.
Science (New York, N.Y.) 1996;271(5255):1586-9.
1996: Doucet J P; Nakabeppu Y; Bedard P J; Hope B T; Nestler E J; Jasmin B J; Chen J S; Iadarola M J; St-Jean M; Wigle N; Blanchet P; Grondin R; Robertson G S
Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of deltaFosB-like protein(s) in both the rodent and primate striatum.
The European journal of neuroscience 1996;8(2):365-81.
1996: Hyman S E; Nestler E J
Initiation and adaptation: a paradigm for understanding psychotropic drug action.
The American journal of psychiatry 1996;153(2):151-62.
1996: Harris H W; Nestler E J
Immunohistochemical studies of mesolimbic dopaminergic neurons in Fischer 344 and Lewis rats.
Brain research 1996;706(1):1-12.
1996: Fitzgerald L W; Ortiz J; Hamedani A G; Nestler E J
Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(1):274-82.
1996: Widnell K L; Self D W; Lane S B; Russell D S; Vaidya V A; Miserendino M J; Rubin C S; Duman R S; Nestler E J
Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens.
The Journal of pharmacology and experimental therapeutics 1996;276(1):306-15.
1995: Self D W; McClenahan A W; Beitner-Johnson D; Terwilliger R Z; Nestler E J
Biochemical adaptations in the mesolimbic dopamine system in response to heroin self-administration.
Synapse (New York, N.Y.) 1995;21(4):312-8.
1995: Ortiz J; Fitzgerald L W; Charlton M; Lane S; Trevisan L; Guitart X; Shoemaker W; Duman R S; Nestler E J
Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system.
Synapse (New York, N.Y.) 1995;21(4):289-98.
1995: Sklair-Tavron L; Nestler E J
Opposing effects of morphine and the neurotrophins, NT-3, NT-4, and BDNF, on locus coeruleus neurons in vitro.
Brain research 1995;702(1-2):117-25.
1995: Nye H E; Hope B T; Kelz M B; Iadarola M; Nestler E J
Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1671-80.
1995: Chen J; Nye H E; Kelz M B; Hiroi N; Nakabeppu Y; Hope B T; Nestler E J
Regulation of delta FosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments.
Molecular pharmacology 1995;48(5):880-9.
1995: Berhow M T; Russell D S; Terwilliger R Z; Beitner-Johnson D; Self D W; Lindsay R M; Nestler E J
Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system.
Neuroscience 1995;68(4):969-79.
1995: Fitzgerald L W; Charlton M E; Duman R S; Nestler E J
Regulation of neuronal nitric oxide synthase by chronic ethanol ingestion.
Synapse (New York, N.Y.) 1995;21(1):93-5.
1995: Ortiz J; DeCaprio J L; Kosten T A; Nestler E J
Strain-selective effects of corticosterone on locomotor sensitization to cocaine and on levels of tyrosine hydroxylase and glucocorticoid receptor in the ventral tegmental area.
Neuroscience 1995;67(2):383-97.
1995: Nestler E J; Terwilliger R Z; Duman R S
Regulation of endogenous ADP-ribosylation by acute and chronic lithium in rat brain.
Journal of neurochemistry 1995;64(5):2319-24.
1995: Rosin D L; Melia K; Knorr A M; Nestler E J; Roth R H; Duman R S
Chronic imipramine administration alters the activity and phosphorylation state of tyrosine hydroxylase in dopaminergic regions of rat brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1995;12(2):113-21.
1995: Fitzgerald L W; Deutch A Y; Gasic G; Heinemann S F; Nestler E J
Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(3 Pt 2):2453-61.
1995: Miserendino M J; Nestler E J
Behavioral sensitization to cocaine: modulation by the cyclic AMP system in the nucleus accumbens.
Brain research 1995;674(2):299-306.
1995: Ortiz J; Harris H W; Guitart X; Terwilliger R Z; Haycock J W; Nestler E J
Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: regional distribution and regulation by chronic morphine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(2):1285-97.
1995: Lee M J; Saijoh K; Nestler E J; Duman R S; Sumino K
Regional differences in expression of osteonectin mRNA after administration of cadmium to rats.
Archives of toxicology 1995;69(9):590-5.
1995: Fitzgerald L W; Nestler E J
Molecular and cellular adaptations in signal transduction pathways following ethanol exposure.
Clinical neuroscience (New York, N.Y.) 1995;3(3):165-73.
1995: Self D W; Nestler E J
Molecular mechanisms of drug reinforcement and addiction.
Annual review of neuroscience 1995;18():463-95.
1994: Nestler E J
Hard target: understanding dopaminergic neurotransmission.
Cell 1994;79(6):923-6.
1994: Duman R S; Heninger G R; Nestler E J
Molecular psychiatry. Adaptations of receptor-coupled signal transduction pathways underlying stress- and drug-induced neural plasticity.
The Journal of nervous and mental disease 1994;182(12):692-700.
1994: Widnell K L; Russell D S; Nestler E J
Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10947-51.
1994: Hope B T; Nye H E; Kelz M B; Self D W; Iadarola M J; Nakabeppu Y; Duman R S; Nestler E J
Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.
Neuron 1994;13(5):1235-44.
1994: Terwilliger R Z; Ortiz J; Guitart X; Nestler E J
Chronic morphine administration increases beta-adrenergic receptor kinase (beta ARK) levels in the rat locus coeruleus.
Journal of neurochemistry 1994;63(5):1983-6.
1994: Self D W; Terwilliger R Z; Nestler E J; Stein L
Inactivation of Gi and G(o) proteins in nucleus accumbens reduces both cocaine and heroin reinforcement.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(10):6239-47.
1994: Nestler E J
Molecular neurobiology of drug addiction.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1994;11(2):77-87.
1994: Hope B T; Kelz M B; Duman R S; Nestler E J
Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(7):4318-28.
1994: Kosten T A; Miserendino M J; Chi S; Nestler E J
Fischer and Lewis rat strains show differential cocaine effects in conditioned place preference and behavioral sensitization but not in locomotor activity or conditioned taste aversion.
The Journal of pharmacology and experimental therapeutics 1994;269(1):137-44.
1994: Trevisan L; Fitzgerald L W; Brose N; Gasic G P; Heinemann S F; Duman R S; Nestler E J
Chronic ingestion of ethanol up-regulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus.
Journal of neurochemistry 1994;62(4):1635-8.
1994: Nestler E J; Guitart X; Ortiz J; Trevisan L
Second messenger and protein phosphorylation mechanisms underlying possible genetic vulnerability to alcoholism.
Annals of the New York Academy of Sciences 1994;708():108-18.
1994: Kosten T A; Nestler E J
Clozapine attenuates cocaine conditioned place preference.
Life sciences 1994;55(1):PL9-14.
1994: Nestler E J; Alreja M; Aghajanian G K
Molecular and cellular mechanisms of opiate action: studies in the rat locus coeruleus.
Brain research bulletin 1994;35(5-6):521-8.
1994: Sklair-Tavron L; Nestler E J; Segal M
Locus coeruleus (LC)--target interaction and cAMP in control of LC development.
Brain research bulletin 1994;35(5-6):397-402.
1993: Nestler E J; Hope B T; Widnell K L
Drug addiction: a model for the molecular basis of neural plasticity.
Neuron 1993;11(6):995-1006.
1993: Beitner-Johnson D; Guitart X; Nestler E J
Glial fibrillary acidic protein and the mesolimbic dopamine system: regulation by chronic morphine and Lewis-Fischer strain differences in the rat ventral tegmental area.
Journal of neurochemistry 1993;61(5):1766-73.
1993: Miserendino M J; Guitart X; Terwilliger R Z; Chi S; Nestler E J
Individual differences in locomotor activity are associated with levels of tyrosine hydroxylase and neurofilament proteins in the ventral tegmental area of sprague-dawley rats.
Molecular and cellular neurosciences 1993;4(5):440-8.
1993: Duman R S; Terwilliger R Z; Nestler E J
Alterations in nitric oxide-stimulated endogenous ADP-ribosylation associated with long-term potentiation in rat hippocampus.
Journal of neurochemistry 1993;61(4):1542-5.
1993: Beitner-Johnson D; Nestler E J
Chronic morphine impairs axoplasmic transport in the rat mesolimbic dopamine system.
Neuroreport 1993;5(1):57-60.
1993: Beitner-Johnson D; Nestler E J
Chronic morphine decreases insulin-like growth factor-I levels in the ventral tegmental area of the rat brain.
Annals of the New York Academy of Sciences 1993;692():246-8.
1993: Vaccarino F M; Hayward M D; Le H N; Hartigan D J; Duman R S; Nestler E J
Induction of immediate early genes by cyclic AMP in primary cultures of neurons from rat cerebral cortex.
Brain research. Molecular brain research 1993;19(1-2):76-82.
1993: Xin W; Terwilliger R Z; Rimland J; Wong M L; Nestler E J; Duman R S
Characterization and functional expression of a somatostatin receptor coupled to adenylyl cyclase.
Molecular and cellular neurosciences 1993;4(3):259-66.
1993: Guitart X; Lumeng L; Li T K; Nestler E J
Alcohol-preferring and nonpreferring rats display different levels of neurofilament proteins in the ventral tegmental area.
Alcoholism, clinical and experimental research 1993;17(3):580-5.
1993: Guitart X; Kogan J H; Berhow M; Terwilliger R Z; Aghajanian G K; Nestler E J
Lewis and Fischer rat strains display differences in biochemical, electrophysiological and behavioral parameters: studies in the nucleus accumbens and locus coeruleus of drug naive and morphine-treated animals.
Brain research 1993;611(1):7-17.
1993: Bergson C; Zhao H; Saijoh K; Duman R S; Nestler E J
Ezrin and osteonectin, two proteins associated with cell shape and growth, are enriched in the locus coeruleus.
Molecular and cellular neurosciences 1993;4(1):64-73.
1993: Guitart X; Nestler E J
Second messenger and protein phosphorylation mechanisms underlying opiate addiction: studies in the rat locus coeruleus.
Neurochemical research 1993;18(1):5-13.
1993: Nestler E J
Cellular responses to chronic treatment with drugs of abuse.
Critical reviews in neurobiology 1993;7(1):23-39.
1993: Nestler E J; Bergson C M; Gultart X; Hope B T
Regulation of neural gene expression in opiate and cocaine addiction.
NIDA research monograph 1993;125():92-116.
1992: Guitart X; Beitner-Johnson D; Marby D W; Kosten T A; Nestler E J
Fischer and Lewis rat strains differ in basal levels of neurofilament proteins and their regulation by chronic morphine in the mesolimbic dopamine system.
Synapse (New York, N.Y.) 1992;12(3):242-53.
1992: Guitart X; Nestler E J
Chronic administration of lithium or other antidepressants increases levels of DARPP-32 in rat frontal cortex.
Journal of neurochemistry 1992;59(3):1164-7.
1992: Hope B; Kosofsky B; Hyman S E; Nestler E J
Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):5764-8.
1992: Nestler E J
Molecular mechanisms of drug addiction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(7):2439-50.
1992: Beitner-Johnson D; Guitart X; Nestler E J
Neurofilament proteins and the mesolimbic dopamine system: common regulation by chronic morphine and chronic cocaine in the rat ventral tegmental area.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(6):2165-76.
1992: Beitner-Johnson D; Guitart X; Nestler E J
Common intracellular actions of chronic morphine and cocaine in dopaminergic brain reward regions.
Annals of the New York Academy of Sciences 1992;654():70-87.
1992: Guitart X; Thompson M A; Mirante C K; Greenberg M E; Nestler E J
Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus.
Journal of neurochemistry 1992;58(3):1168-71.
1992: Melia K R; Rasmussen K; Terwilliger R Z; Haycock J W; Nestler E J; Duman R S
Coordinate regulation of the cyclic AMP system with firing rate and expression of tyrosine hydroxylase in the rat locus coeruleus: effects of chronic stress and drug treatments.
Journal of neurochemistry 1992;58(2):494-502.
1992: Petzel D; Ganz M B; Nestler E J; Lewis J J; Goldenring J; Akcicek F; Hayslett J P
Correlates of aldosterone-induced increases in Cai2+ and Isc suggest that Cai2+ is the second messenger for stimulation of apical membrane conductance.
The Journal of clinical investigation 1992;89(1):150-6.
1992: Kogan J H; Nestler E J; Aghajanian G K
Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus neurons in brain slices from opiate-dependent rats.
European journal of pharmacology 1992;211(1):47-53.
1992: Vaccarino F M; Hayward M D; Nestler E J; Duman R S; Tallman J F
Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons.
Brain research. Molecular brain research 1992;12(1-3):233-41.
1992: Aghajanian G K; Alreja M; Nestler E J; Kogan J H
Dual mechanisms of opiate dependence in the locus coeruleus.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():143A-144A.
1992: Melia K R; Nestler E J; Duman R S
Chronic imipramine treatment normalizes levels of tyrosine hydroxylase in the locus coeruleus of chronically stressed rats.
Psychopharmacology 1992;108(1-2):23-6.
1991: Colin S F; Chang H C; Mollner S; Pfeuffer T; Reed R R; Duman R S; Nestler E J
Chronic lithium regulates the expression of adenylate cyclase and Gi-protein alpha subunit in rat cerebral cortex.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10634-7.
1991: Duman R S; Terwilliger R Z; Nestler E J
Endogenous ADP-ribosylation in brain: initial characterization of substrate proteins.
Journal of neurochemistry 1991;57(6):2124-32.
1991: Rimland J; Xin W; Sweetnam P; Saijoh K; Nestler E J; Duman R S
Sequence and expression of a neuropeptide Y receptor cDNA.
Molecular pharmacology 1991;40(6):869-75.
1991: Campeau S; Hayward M D; Hope B T; Rosen J B; Nestler E J; Davis M
Induction of the c-fos proto-oncogene in rat amygdala during unconditioned and conditioned fear.
Brain research 1991;565(2):349-52.
1991: Beitner-Johnson D; Guitart X; Nestler E J
Dopaminergic brain reward regions of Lewis and Fischer rats display different levels of tyrosine hydroxylase and other morphine- and cocaine-regulated phosphoproteins.
Brain research 1991;561(1):147-50.
1991: Lovenberg T W; Nichols D E; Nestler E J; Roth R H; Mailman R B
Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors.
Brain research 1991;556(1):101-7.
1991: Beitner-Johnson D; Nestler E J
Morphine and cocaine exert common chronic actions on tyrosine hydroxylase in dopaminergic brain reward regions.
Journal of neurochemistry 1991;57(1):344-7.
1991: Terwilliger R Z; Beitner-Johnson D; Sevarino K A; Crain S M; Nestler E J
A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function.
Brain research 1991;548(1-2):100-10.
1991: Kosten T A; Marby D W; Nestler E J
Cocaine conditioned place preference is attenuated by chronic buprenorphine treatment.
Life sciences 1991;49(24):PL201-6.
1990: Duman R S; Winston S M; Clark J A; Nestler E J
Corticosterone regulates the expression of ADP-ribosylation factor messenger RNA and protein in rat cerebral cortex.
Journal of neurochemistry 1990;55(5):1813-6.
1990: Nestler E J; McMahon A; Sabban E L; Tallman J F; Duman R S
Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7522-6.
1990: Nestler E J; Terwilliger R Z; Walker J R; Sevarino K A; Duman R S
Chronic cocaine treatment decreases levels of the G protein subunits Gi alpha and Go alpha in discrete regions of rat brain.
Journal of neurochemistry 1990;55(3):1079-82.
1990: Guitart X; Hayward M; Nisenbaum L K; Beitner-Johnson D B; Haycock J W; Nestler E J
Identification of MARPP-58, a morphine- and cyclic AMP-regulated phosphoprotein of 58 kDa, as tyrosine hydroxylase: evidence for regulation of its expression by chronic morphine in the rat locus coeruleus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(8):2649-59.
1990: Hayward M D; Duman R S; Nestler E J
Induction of the c-fos proto-oncogene during opiate withdrawal in the locus coeruleus and other regions of rat brain.
Brain research 1990;525(2):256-66.
1990: Rasmussen K; Beitner-Johnson D B; Krystal J H; Aghajanian G K; Nestler E J
Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(7):2308-17.
1990: Winston S M; Hayward M D; Nestler E J; Duman R S
Chronic electroconvulsive seizures down-regulate expression of the immediate-early genes c-fos and c-jun in rat cerebral cortex.
Journal of neurochemistry 1990;54(6):1920-5.
1990: Guitart X; Nestler E J
Identification of MARPP (14-20), morphine- and cyclic AMP-regulated phosphoproteins of 14-20 kDa, as myelin basic proteins: evidence for their acute and chronic regulation by morphine in rat brain.
Brain research 1990;516(1):57-65.
1989: Guitart X; Nestler E J
Identification of morphine- and cyclic AMP-regulated phosphoproteins (MARPPs) in the locus coeruleus and other regions of rat brain: regulation by acute and chronic morphine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1989;9(12):4371-87.
1989: Nestler E J; Terwilliger R Z; Duman R S
Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex.
Journal of neurochemistry 1989;53(5):1644-7.
1989: Duman R S; Terwilliger R Z; Nestler E J; Tallman J F
Sodium and potassium regulation of guanine nucleotide-stimulated adenylate cyclase in brain.
Biochemical pharmacology 1989;38(12):1909-14.
1989: Saito N; Guitart X; Hayward M; Tallman J F; Duman R S; Nestler E J
Corticosterone differentially regulates the expression of Gs alpha and Gi alpha messenger RNA and protein in rat cerebral cortex.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3906-10.
1989: Beitner D B; Duman R S; Nestler E J
A novel action of morphine in the rat locus coeruleus: persistent decrease in adenylate cyclase.
Molecular pharmacology 1989;35(5):559-64.
1989: Nestler E J; Terwilliger R Z; Halm E
Corticosterone increases protein tyrosine kinase activity in the locus coeruleus and other monoaminergic nuclei of rat brain.
Molecular pharmacology 1989;35(3):265-70.
1989: Nestler E J; Erdos J J; Terwilliger R; Duman R S; Tallman J F
Regulation of G proteins by chronic morphine in the rat locus coeruleus.
Brain research 1989;476(2):230-9.
1989: Nestler E J; Terwilliger R; Beitner D
Regulation by chronic clonidine of adenylate cyclase and cyclic AMP-dependent protein kinase in the rat locus coeruleus.
Life sciences 1989;45(12):1073-80.
1988: Bean A J; Shepard P D; Bunney B S; Nestler E J; Roth R H
The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum.
Molecular pharmacology 1988;34(6):715-8.
1988: Sweetnam P M; Lloyd J; Gallombardo P; Malison R T; Gallager D W; Tallman J F; Nestler E J
Phosphorylation of the GABAa/benzodiazepine receptor alpha subunit by a receptor-associated protein kinase.
Journal of neurochemistry 1988;51(4):1274-84.
1988: Duman R S; Tallman J F; Nestler E J
Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.
The Journal of pharmacology and experimental therapeutics 1988;246(3):1033-9.
1988: Innis R B; Nestler E J; Aghajanian G K
Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons.
Brain research 1988;459(1):27-36.
1988: Nestler E J; Tallman J F
Chronic morphine treatment increases cyclic AMP-dependent protein kinase activity in the rat locus coeruleus.
Molecular pharmacology 1988;33(2):127-32.
1987: Sweetnam P; Nestler E; Gallombardo P; Brown S; Duman R; Bracha H S; Tallman J
Comparison of the molecular structure of GABA/benzodiazepine receptors purified from rat and human cerebellum.
Brain research 1987;388(3):223-33.
1986: Nestler E J; Greengard P
Synapsin I: a review of its distribution and biological regulation.
Progress in brain research 1986;69():323-39.
1985: Goelz S E; Nestler E J; Greengard P
Phylogenetic survey of proteins related to synapsin I and biochemical analysis of four such proteins from fish brain.
Journal of neurochemistry 1985;45(1):63-72.
1984: Nestler E J; Walaas S I; Greengard P
Neuronal phosphoproteins: physiological and clinical implications.
Science (New York, N.Y.) 1984;225(4668):1357-64.
1984: Perdahl E; Adolfsson R; Alafuzoff I; Albert K A; Nestler E J; Greengard P; Winblad B
Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multi-infarct dementia.
Journal of neural transmission 1984;60(2):133-41.
1984: Nestler E J; Greengard P
Neuron-specific phosphoproteins in mammalian brain.
Advances in cyclic nucleotide and protein phosphorylation research 1984;17():483-8.
1983: Nestler E J; Greengard P
Protein phosphorylation in the brain.
Nature 1983;305(5935):583-8.
1982: Nestler E J; Greengard P
Distribution of protein I and regulation of its state of phosphorylation in the rabbit superior cervical ganglion.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1982;2(8):1011-23.
1982: Nestler E J; Zata M; Greengard P
A diurnal rhythm in pineal protein 1 content mediated by beta-adrenergic neurotransmission.
Science (New York, N.Y.) 1982;217(4557):357-9.
1982: Fried G; Nestler E J; De Camilli P; Stjärne L; Olson L; Lundberg J M; Hökfelt T; Ouimet C C; Greengard P
Cellular and subcellular localization of protein I in the peripheral nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(8):2717-21.
1982: Nestler E J; Greengard P
Nerve impulses increase the phosphorylation state of protein I in rabbit superior cervical ganglion.
Nature 1982;296(5856):452-4.
1981: Nestler E J; Rainbow T C; McEwen B S; Greengard P
Corticosterone increases the amount of protein 1, a neuron-specific phosphoprotein, in rat hippocampus.
Science (New York, N.Y.) 1981;212(4499):1162-4.
1981: Goelz S E; Nestler E J; Chehrazi B; Greengard P
Distribution of protein I in mammalian brain as determined by a detergent-based radioimmunoassay.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(4):2130-4.
1980: Nestler E J; Greengard P
Dopamine and depolarizing agents regulate the state of phosphorylation of protein I in the mammalian superior cervical sympathetic ganglion.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(12):7479-83.
1978: Nestler E J; Beam K G; Greengard P
Nicotinic cholinergic stimulation increases cyclic GMP levels in vertebrate skeletal muscle.
Nature 1978;275(5679):451-3.
1977: Beam K G; Nestler E J; Greengard P
Increased cyclic GMP levels associated with contraction in muscle fibres of the giant barnacle.
Nature 1977;267(5611):534-6.

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