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Michael Neuberger

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Anita Chandra; Michael S Neuberger; Simon Andrews; Febe Van Maldegem; Cristina Rada
Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice.
Benjamin Jm Taylor; Yee Ling Wu; Peter J Campbell; Serena Nik-Zainal; Cristina Rada; Keiran Raine; Lucy A Stebbings; Michael R Stratton; Michael S Neuberger
DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.
Julien Häsler; Cristina Rada; Michael S Neuberger
The cytoplasmic AID complex.

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2013: Anita Chandra; Michael S Neuberger; Simon Andrews; Febe Van Maldegem; Cristina Rada
Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice.
Cell cycle (Georgetown, Tex.) 2013;12(5):732-42.
2013: Benjamin Jm Taylor; Yee Ling Wu; Peter J Campbell; Serena Nik-Zainal; Cristina Rada; Keiran Raine; Lucy A Stebbings; Michael R Stratton; Michael S Neuberger
DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.
eLife 2013;2():e00534.
2012: Julien Häsler; Cristina Rada; Michael S Neuberger
The cytoplasmic AID complex.
Seminars in immunology 2012;24(4):273-80.
2012: Kristin Kemmerich; Felix A Dingler; Cristina Rada; Michael S Neuberger
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
Nucleic acids research 2012;40(13):6016-25.
2012: Michael S Neuberger
Wartime discoveries on amino acids: functions in protein structure and as a dietary nitrogen source.
The Biochemical journal 2012;2012(1):1-5.
2011: Yasuhiro Uchimura; Cristina Rada; Lance F Barton; Michael S Neuberger
REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase.
The Journal of experimental medicine 2011;208(12):2385-91.
2011: Julien Häsler; Cristina Rada; Michael S Neuberger
Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A).
Proceedings of the National Academy of Sciences of the United States of America 2011;108(45):18366-71.
2011: Sara Pruzina; Quentin J Sattentau; Sueli M Vieira; Gareth T Williams; Marianne Brüggemann; Sarah L Davies; Simon A Jeffs; Galina Kaneva; Alicia Martín-López; Michael S Neuberger
Human monoclonal antibodies to HIV-1 gp140 from mice bearing YAC-based human immunoglobulin transloci.
Protein engineering, design & selection : PEDS 2011;24(10):791-9.
2011: Karuna Ganesh; Michael S Neuberger
The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(4):1123-32.
2011: Julia I Ellyard; Amelie S Benk; Benjamin Taylor; Cristina Rada; Michael S Neuberger
The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin.
European journal of immunology 2011;41(2):485-90.
2011: Meng Wang; Cristina Rada; Michael S Neuberger
A high-throughput assay for DNA deaminases.
Methods in molecular biology (Clifton, N.J.) 2011;718():171-84.
2010: Meng Wang; Cristina Rada; Michael S Neuberger
Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.
The Journal of experimental medicine 2010;207(1):141-53.
2009: Meng Wang; Zizhen Yang; Cristina Rada; Michael S Neuberger
AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity.
Nature structural & molecular biology 2009;16(7):769-76.
2009: Roland Geisberger; Cristina Rada; Michael S Neuberger
The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(16):6736-41.
2008: Silvestro G Conticello; Karuna Ganesh; Kanmin Xue; Mason Lu; Cristina Rada; Michael S Neuberger
Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1.
Molecular cell 2008;31(4):474-84.
2008: Marc-Andre Langlois; Michael S Neuberger
Human APOBEC3G can restrict retroviral infection in avian cells and acts independently of both UNG and SMUG1.
Journal of virology 2008;82(9):4660-4.
2007: Javier Di noia; Gareth T Williams; Denice T Y Chan; Jean-Marie Buerstedde; Geoff S Baldwin; Michael S Neuberger
Dependence of antibody gene diversification on uracil excision.
The Journal of experimental medicine 2007;204(13):3209-19.
2007: Michael S Neuberger; Cristina Rada
Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.
The Journal of experimental medicine 2007;204(1):7-10.
2007: Silvestro G Conticello; Marc-Andre Langlois; Zizhen Yang; Michael S Neuberger
DNA deamination in immunity: AID in the context of its APOBEC relatives.
Advances in immunology 2007;94():37-73.
2007: Javier Di noia; Michael S Neuberger
Molecular mechanisms of antibody somatic hypermutation.
Annual review of biochemistry 2007;76():1-22.
2007: Silvestro G Conticello; Marc-Andre Langlois; Michael S Neuberger
Insights into DNA deaminases.
Nature structural & molecular biology 2007;14(1):7-9.
2006: Kanmin Xue; Cristina Rada; Michael S Neuberger
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.
The Journal of experimental medicine 2006;203(9):2085-94.
2006: Donna A MacDuff; Michael S Neuberger; Reuben S Harris
MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells.
Molecular immunology 2006;43(8):1099-108.
2006: Javier Di noia; Cristina Rada; Michael S Neuberger
SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.
The EMBO journal 2006;25(3):585-95.
2005: Marie C Mikl; Ian N Watt; Mason Lu; Wolf Reik; Sarah L Davies; Michael S Neuberger; Cristina Rada
Mice deficient in APOBEC2 and APOBEC3.
Molecular and cellular biology 2005;25(16):7270-7.
2005: Michael S Neuberger; Javier Di noia; Rupert C L Beale; Gareth T Williams; Zizhen Yang; Cristina Rada
Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.
Nature reviews. Immunology 2005;5(2):171-8.
2005: Silvestro G Conticello; Cornelia J F Thomas; Svend K Petersen-Mahrt; Michael S Neuberger
Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases.
Molecular biology and evolution 2005;22(2):367-77.
2005: Marc-Andre Langlois; Rupert C L Beale; Silvestro G Conticello; Michael S Neuberger
Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities.
Nucleic acids research 2005;33(6):1913-23.
2004: Cristina Rada; Javier Di noia; Michael S Neuberger
Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation.
Molecular cell 2004;16(2):163-71.
2004: Rupert C L Beale; Svend K Petersen-Mahrt; Ian N Watt; Reuben S Harris; Cristina Rada; Michael S Neuberger
Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo.
Journal of molecular biology 2004;337(3):585-96.
2004: Javier Di noia; Michael S Neuberger
Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.
European journal of immunology 2004;34(2):504-8.
2003: Silvestro G Conticello; Reuben S Harris; Michael S Neuberger
The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G.
Current biology : CB 2003;13(22):2009-13.
2003: Mats Bemark; Michael S Neuberger
By-products of immunoglobulin somatic hypermutation.
Genes, chromosomes & cancer 2003;38(1):32-9.
2003: Reuben S Harris; Ann M Sheehy; Heather M Craig; Michael H Malim; Michael S Neuberger
DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses.
Nature immunology 2003;4(7):641-3.
2003: Reuben S Harris; Kate N Bishop; Ann M Sheehy; Heather M Craig; Svend K Petersen-Mahrt; Ian N Watt; Michael S Neuberger; Michael H Malim
DNA deamination mediates innate immunity to retroviral infection.
Cell 2003;113(6):803-9.
2003: Michael S Neuberger; Reuben S Harris; Javier Di noia; Svend K Petersen-Mahrt
Immunity through DNA deamination.
Trends in biochemical sciences 2003;28(6):305-12.
2003: Svend K Petersen-Mahrt; Michael S Neuberger
In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1).
The Journal of biological chemistry 2003;278(22):19583-6.
2002: Reuben S Harris; Svend K Petersen-Mahrt; Michael S Neuberger
RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.
Molecular cell 2002;10(5):1247-53.
2002: Sarah J Cumbers; Gareth T Williams; Sarah L Davies; Richard L Grenfell; Shunichi Takeda; Facundo D Batista; Julian E Sale; Michael S Neuberger
Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines.
Nature biotechnology 2002;20(11):1129-34.
2002: Cristina Rada; Gareth T Williams; Hilde Nilsen; Deborah E Barnes; Tomas Lindahl; Michael S Neuberger
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice.
Current biology : CB 2002;12(20):1748-55.
2002: Javier Di noia; Michael S Neuberger
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.
Nature 2002;419(6902):43-8.
2002: Susana Magadán; Mónica Valladares; E Suarez; Isabel Sanjuán; Ana Molina; C Ayling; Sarah L Davies; Xiangang Zou; Gareth T Williams; Michael S Neuberger; Marianne Brüggemann; ÁFRICA GONZÁLEZ-FERNÁNDEZ; F Diaz-Espada; A González-Fernandez
Production of antigen-specific human monoclonal antibodies: comparison of mice carrying IgH/kappa or IgH/kappa/lambda transloci.
BioTechniques 2002;33(3):680, 682, 684 passim.
2002: Michael S Neuberger
Novartis Medal Lecture. Antibodies: a paradigm for the evolution of molecular recognition.
Biochemical Society transactions 2002;30(4):341-50.
2002: Svend K Petersen-Mahrt; Reuben S Harris; Michael S Neuberger
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification.
Nature 2002;418(6893):99-103.
2002: Reuben S Harris; Julian E Sale; Svend K Petersen-Mahrt; Michael S Neuberger
AID is essential for immunoglobulin V gene conversion in a cultured B cell line.
Current biology : CB 2002;12(5):435-8.
2002: Astrid Lanoue; Facundo D Batista; Mairi Stewart; Michael S Neuberger
Interaction of CD22 with alpha2,6-linked sialoglycoconjugates: innate recognition of self to dampen B cell autoreactivity?
European journal of immunology 2002;32(2):348-55.
2001: Michael R Ehrenstein; Cristina Rada; A M Jones; César Milstein; Michael S Neuberger
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14553-8.
2001: R S Harris; Debbie Croom-Carter; Alan B Rickinson; Michael S Neuberger
Epstein-Barr virus and the somatic hypermutation of immunoglobulin genes in Burkitt's lymphoma cells.
Journal of virology 2001;75(21):10488-92.
2001: Julian E Sale; D M Calandrini; M Takata; S Takeda; Michael S Neuberger
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation.
Nature 2001;412(6850):921-6.
2001: Facundo D Batista; D Iber; Michael S Neuberger
B cells acquire antigen from target cells after synapse formation.
Nature 2001;411(6836):489-94.
2001: CJ Jolly; Michael S Neuberger
Somatic hypermutation of immunoglobulin kappa transgenes: association of mutability with demethylation.
Immunology and cell biology 2001;79(1):18-22.
2001: Julian E Sale; Mats Bemark; Gareth T Williams; CJ Jolly; Michael R Ehrenstein; Cristina Rada; César Milstein; Michael S Neuberger
In vivo and in vitro studies of immunoglobulin gene somatic hypermutation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1405):21-8.
2000: Mats Bemark; Julian E Sale; H J Kim; C Berek; R A Cosgrove; Michael S Neuberger
Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity.
The Journal of experimental medicine 2000;192(10):1509-14.
2000: Mats Bemark; A A Khamlichi; S L Davies; Michael S Neuberger
Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro.
Current biology : CB 2000;10(19):1213-6.
2000: Charles Mary; Catherine Laporte; D Parzy; ML Santiago; F Stefani; Frédéric Lajaunias; R Michael E Parkhouse; TL O'Keefe; Michael S Neuberger; Shozo Izui; Luc Reininger
Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):2987-96.
2000: Michael S Neuberger; J Scott
Immunology. RNA editing AIDs antibody diversification?
Science (New York, N.Y.) 2000;289(5485):1705-6.
2000: Gareth T Williams; CJ Jolly; J Köhler; Michael S Neuberger
The contribution of somatic hypermutation to the diversity of serum immunoglobulin: dramatic increase with age.
Immunity 2000;13(3):409-17.
2000: Mats Bemark; Michael S Neuberger
The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line.
Oncogene 2000;19(30):3404-10.
2000: Michael R Ehrenstein; H Terence Cook; Michael S Neuberger
Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies.
The Journal of experimental medicine 2000;191(7):1253-8.
2000: Michael S Neuberger; Michael R Ehrenstein; Cristina Rada; Julian E Sale; Facundo D Batista; G Williams; César Milstein
Memory in the B-cell compartment: antibody affinity maturation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1395):357-60.
2000: Facundo D Batista; Michael S Neuberger
B cells extract and present immobilized antigen: implications for affinity discrimination.
The EMBO journal 2000;19(4):513-20.
2000: Michael S Neuberger; Julian E Sale; S J Cumbers; CJ Jolly; Mats Bemark; Michael R Ehrenstein; Astrid Lanoue; Marianne Brüggemann; Facundo D Batista; Sarah L Davies; Gareth T Williams
Diversification and selection mechanisms for the production of protein repertoires: lessons from the immune system.
Applied biochemistry and biotechnology 2000;83(1-3):53-60; discussion 60-2, 145-53.
1999: IC Nicholson; Xiangang Zou; AV Popov; G P Cook; E M Corps; S Humphries; C Ayling; Beatriz Goyenechea; Jian Xian; Michael J Taussig; Michael S Neuberger; Marianne Brüggemann
Antibody repertoires of four- and five-feature translocus mice carrying human immunoglobulin heavy chain and kappa and lambda light chain yeast artificial chromosomes.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6898-906.
1999: Michael R Ehrenstein; Michael S Neuberger
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.
The EMBO journal 1999;18(12):3484-90.
1999: TL O'Keefe; Gareth T Williams; Facundo D Batista; Michael S Neuberger
Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies.
The Journal of experimental medicine 1999;189(8):1307-13.
1999: Michael S Neuberger; Astrid Lanoue; Michael R Ehrenstein; Facundo D Batista; Julian E Sale; Gareth T Williams
Antibody diversification and selection in the mature B-cell compartment.
Cold Spring Harbor symposia on quantitative biology 1999;64():211-6.
1998: Julian E Sale; Michael S Neuberger
TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line.
Immunity 1998;9(6):859-69.
1998: Michael R Ehrenstein; TL O'Keefe; Sarah L Davies; Michael S Neuberger
Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10089-93.
1998: César Milstein; Michael S Neuberger; R Staden
Both DNA strands of antibody genes are hypermutation targets.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8791-4.
1998: Cristina Rada; Michael R Ehrenstein; Michael S Neuberger; César Milstein
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting.
Immunity 1998;9(1):135-41.
1998: TL O'Keefe; Gareth T Williams; Sarah L Davies; Michael S Neuberger
Mice carrying a CD20 gene disruption.
Immunogenetics 1998;48(2):125-32.
1998: Facundo D Batista; Michael S Neuberger
Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate.
Immunity 1998;8(6):751-9.
1998: Michael S Neuberger; Michael R Ehrenstein; N Klix; CJ Jolly; J Yélamos; Cristina Rada; César Milstein
Monitoring and interpreting the intrinsic features of somatic hypermutation.
Immunological reviews 1998;162():107-16.
1998: N Klix; CJ Jolly; Sarah L Davies; Marianne Brüggemann; Gareth T Williams; Michael S Neuberger
Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain.
European journal of immunology 1998;28(1):317-26.
1997: Michael S Neuberger
Antigen receptor signaling gives lymphocytes a long life.
Cell 1997;90(6):971-3.
1997: Beatriz Goyenechea; N Klix; J Yélamos; Gareth T Williams; A Riddell; Michael S Neuberger; César Milstein
Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.
The EMBO journal 1997;16(13):3987-94.
1997: V R Aluvihare; A A Khamlichi; Gareth T Williams; L Adorini; Michael S Neuberger
Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: importance depends on the nature of the antigen-antibody interaction.
The EMBO journal 1997;16(12):3553-62.
1997: Y M Teh; Michael S Neuberger
The immunoglobulin (Ig)alpha and Igbeta cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice.
The Journal of experimental medicine 1997;185(10):1753-8.
1997: CJ Jolly; N Klix; Michael S Neuberger
Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice.
Nucleic acids research 1997;25(10):1913-9.
1996: TL O'Keefe; Gareth T Williams; Sarah L Davies; Michael S Neuberger
Hyperresponsive B cells in CD22-deficient mice.
Science (New York, N.Y.) 1996;274(5288):798-801.
1996: Kerstin B Meyer; Y M Teh; Michael S Neuberger
The Ig kappa 3'-enhancer triggers gene expression in early B lymphocytes but its activity is enhanced on B cell activation.
International immunology 1996;8(10):1561-8.
1996: S D Wagner; G Gross; G P Cook; Sarah L Davies; Michael S Neuberger
Antibody expression from the core region of the human IgH locus reconstructed in transgenic mice using bacteriophage P1 clones.
Genomics 1996;35(3):405-14.
1996: Marianne Brüggemann; Michael S Neuberger
Strategies for expressing human antibody repertoires in transgenic mice.
Immunology today 1996;17(8):391-7.
1996: CJ Jolly; S D Wagner; Cristina Rada; N Klix; César Milstein; Michael S Neuberger
The targeting of somatic hypermutation.
Seminars in immunology 1996;8(3):159-68.
1996: S D Wagner; J G Elvin; P Norris; J M McGregor; Michael S Neuberger
Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D).
International immunology 1996;8(5):701-5.
1996: S D Wagner; Michael S Neuberger
Somatic hypermutation of immunoglobulin genes.
Annual review of immunology 1996;14():441-57.
1995: S D Wagner; César Milstein; Michael S Neuberger
Codon bias targets mutation.
Nature 1995;376(6543):732.
1995: J Yélamos; N Klix; Beatriz Goyenechea; F Lozano; Y L Chui; A González Fernández; Richard Pannell; Michael S Neuberger; ÁFRICA GONZÁLEZ-FERNÁNDEZ
Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.
Nature 1995;376(6537):225-9.
1995: G P Cook; K B Meyer; Michael S Neuberger; S Pettersson
Regulated activity of the IgH intron enhancer (E mu) in the T lymphocyte lineage.
International immunology 1995;7(1):89-95.
1994: ÁFRICA GONZÁLEZ-FERNÁNDEZ; S K Gupta; Richard Pannell; Michael S Neuberger; César Milstein
Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12614-8.
1994: S D Wagner; AV Popov; Sarah L Davies; Jian Xian; Michael S Neuberger; Marianne Brüggemann
The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci.
European journal of immunology 1994;24(11):2672-81.
1994: S D Wagner; Gareth T Williams; T Larson; Michael S Neuberger; D Kitamura; K Rajewsky; Jian Xian; Marianne Brüggemann
Antibodies generated from human immunoglobulin miniloci in transgenic mice.
Nucleic acids research 1994;22(8):1389-93.
1994: A G Betz; César Milstein; ÁFRICA GONZÁLEZ-FERNÁNDEZ; Richard Pannell; T Larson; Michael S Neuberger
Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region.
Cell 1994;77(2):239-48.
1994: Gareth T Williams; C J Peaker; K J Patel; Michael S Neuberger
The alpha/beta sheath and its cytoplasmic tyrosines are required for signaling by the B-cell antigen receptor but not for capping or for serine/threonine-kinase recruitment.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(2):474-8.
1993: Gareth T Williams; P Dariavach; Ashok R Venkitaraman; D J Gilmore; Michael S Neuberger
Membrane immunoglobulin without sheath or anchor.
Molecular immunology 1993;30(16):1427-32.
1993: K J Patel; Michael S Neuberger
Antigen presentation by the B cell antigen receptor is driven by the alpha/beta sheath and occurs independently of its cytoplasmic tyrosines.
Cell 1993;74(5):939-46.
1993: A G Betz; Michael S Neuberger; César Milstein
Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes.
Immunology today 1993;14(8):405-11.
1993: N P Davies; I R Rosewell; J C Richardson; G P Cook; Michael S Neuberger; B H Brownstein; M L Norris; Marianne Brüggemann
Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin kappa locus.
Bio/technology (Nature Publishing Company) 1993;11(8):911-4.
1993: C J Peaker; Michael S Neuberger
Association of CD22 with the B cell antigen receptor.
European journal of immunology 1993;23(6):1358-63.
1993: Michael S Neuberger; K J Patel; P Dariavach; Keats Nelms; C J Peaker; Gareth T Williams
The mouse B-cell antigen receptor: definition and assembly of the core receptor of the five immunoglobulin isotypes.
Immunological reviews 1993;132():147-61.
1993: A G Betz; Cristina Rada; Richard Pannell; César Milstein; Michael S Neuberger
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2385-8.
1991: Ashok R Venkitaraman; Gareth T Williams; P Dariavach; Michael S Neuberger
The B-cell antigen receptor of the five immunoglobulin classes.
Nature 1991;352(6338):777-81.
1991: M J Sharpe; César Milstein; J M Jarvis; Michael S Neuberger
Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.
The EMBO journal 1991;10(8):2139-45.
1991: P Dariavach; Gareth T Williams; K Campbell; S Pettersson; Michael S Neuberger
The mouse IgH 3'-enhancer.
European journal of immunology 1991;21(6):1499-504.
1990: Marianne Brüggemann; Gareth T Williams; H M Caskey; C Teale; C Spicer; M A Surani; Michael S Neuberger
Construction, function and immunogenicity of recombinant monoclonal antibodies.
Behring Institute Mitteilungen 1990;(87):21-4.
1990: K B Meyer; M J Sharpe; M A Surani; Michael S Neuberger
The importance of the 3'-enhancer region in immunoglobulin kappa gene expression.
Nucleic acids research 1990;18(19):5609-15.
1990: G P Cook; Michael S Neuberger
Lymphoid-specific transcriptional activation by components of the IgH enhancer: studies on the E2/E3 and octanucleotide elements.
Nucleic acids research 1990;18(12):3565-71.
1990: S Pettersson; G P Cook; Marianne Brüggemann; Gareth T Williams; Michael S Neuberger
A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus.
Nature 1990;344(6262):165-8.
1990: Gareth T Williams; Ashok R Venkitaraman; D J Gilmore; Michael S Neuberger
The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface.
The Journal of experimental medicine 1990;171(3):947-52.
1989: Marianne Brüggemann; G Winter; Herman Waldmann; Michael S Neuberger
The immunogenicity of chimeric antibodies.
The Journal of experimental medicine 1989;170(6):2153-7.
1989: Marianne Brüggemann; H M Caskey; C Teale; Herman Waldmann; Gareth T Williams; M A Surani; Michael S Neuberger
A repertoire of monoclonal antibodies with human heavy chains from transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6709-13.
1989: K B Meyer; Michael S Neuberger
The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region.
The EMBO journal 1989;8(7):1959-64.
1989: Michael S Neuberger; H M Caskey; S Pettersson; Gareth T Williams; M A Surani
Isotype exclusion and transgene down-regulation in immunoglobulin-lambda transgenic mice.
Nature 1989;338(6213):350-2.
1989: S Pettersson; M J Sharpe; D R Gilmore; M A Surani; Michael S Neuberger
Cellular selection leads to age-dependent and reversible down-regulation of transgenic immunoglobulin light chain genes.
International immunology 1989;1(5):509-16.
1988: Michael S Neuberger; G P Cook
The expression of immunoglobulin genes.
Immunology today 1988;9(9):278-81.
1988: Michael S Neuberger; Gareth T Williams
The intron requirement for immunoglobulin gene expression is dependent upon the promoter.
Nucleic acids research 1988;16(14B):6713-24.
1988: Marianne Brüggemann; Michael S Neuberger
Novel antibodies by DNA manipulation.
Progress in allergy 1988;45():91-105.
1987: R Sitia; Michael S Neuberger; César Milstein
Regulation of membrane IgM expression in secretory B cells: translational and post-translational events.
The EMBO journal 1987;6(13):3969-77.
1987: Marianne Brüggemann; G T Williams; C I Bindon; M R Clark; M R Walker; Roy Jefferis; Herman Waldmann; Michael S Neuberger
Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.
The Journal of experimental medicine 1987;166(5):1351-61.
1987: A Cattaneo; Michael S Neuberger
Polymeric immunoglobulin M is secreted by transfectants of non-lymphoid cells in the absence of immunoglobulin J chain.
The EMBO journal 1987;6(9):2753-8.
1983: Michael S Neuberger
Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.
The EMBO journal 1983;2(8):1373-8.