Klaus Neubert

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Physiology

Lymphocyte Activation

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Reinhold Dirk; Goihl Alexander; Wrenger Sabine; Reinhold Annegret; Kühlmann Ulrike C; Faust Jürgen; Neubert Klaus; Thielitz Anja; Brocke Stefan; Täger Michael; Ansorge Siegfried; Bank Ute
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Ansorge Siegfried; Bank Ute; Heimburg Anke; Helmuth Martin; Koch Gudrun; Tadje Janine; Lendeckel Uwe; Wolke Carmen; Neubert Klaus; Faust Jürgen; Fuchs Petra; Reinhold Dirk; Thielitz Anja; Täger Michael
Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions.
Thielitz Anja; Vetter Robert W; Schultze Bianca; Wrenger Sabine; Simeoni Luca; Ansorge Siegfried; Neubert Klaus; Faust Jürgen; Lindenlaub Petra; Gollnick Harald P M; Reinhold Dirk
Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts.

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All Publications

2009: Reinhold Dirk; Goihl Alexander; Wrenger Sabine; Reinhold Annegret; Kühlmann Ulrike C; Faust Jürgen; Neubert Klaus; Thielitz Anja; Brocke Stefan; Täger Michael; Ansorge Siegfried; Bank Ute
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2009;47(3):268-74.
2009: Ansorge Siegfried; Bank Ute; Heimburg Anke; Helmuth Martin; Koch Gudrun; Tadje Janine; Lendeckel Uwe; Wolke Carmen; Neubert Klaus; Faust Jürgen; Fuchs Petra; Reinhold Dirk; Thielitz Anja; Täger Michael
Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2009;47(3):253-61.
2008: Thielitz Anja; Vetter Robert W; Schultze Bianca; Wrenger Sabine; Simeoni Luca; Ansorge Siegfried; Neubert Klaus; Faust Jürgen; Lindenlaub Petra; Gollnick Harald P M; Reinhold Dirk
Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts.
The Journal of investigative dermatology 2008;128(4):855-66.
2008: Wrenger Sabine; Faust Jurgen; Mrestani-Klaus Carmen; Brandt Wolfgang; Thielitz Anja; Neubert Klaus; Reinhold Dirk
Non-substrate peptides influencing dipeptidyl peptidase IV/CD26 activity and immune cell function.
Frontiers in bioscience : a journal and virtual library 2008;13():3194-201.
2008: Reinhold Dirk; Bank Ute; Täger Michael; Ansorge Siegfried; Wrenger Sabine; Thielitz Anja; Lendeckel Uwe; Faust Jürgen; Neubert Klaus; Brocke Stefan
DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis.
Frontiers in bioscience : a journal and virtual library 2008;13():2356-63.
2007: Knütter Ilka; Hartrodt Bianka; Tóth Géza; Keresztes Attila; Kottra Gabor; Mrestani-Klaus Carmen; Born Ilona; Daniel Hannelore; Neubert Klaus; Brandsch Matthias
Synthesis and characterization of a new and radiolabeled high-affinity substrate for H+/peptide cotransporters.
The FEBS journal 2007;274(22):5905-14.
2007: Reinhold Dirk; Biton Aliza; Goihl Alexander; Pieper Stefanie; Lendeckel Uwe; Faust Jürgen; Neubert Klaus; Bank Ute; Täger Michael; Ansorge Siegfried; Brocke Stefan
Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses.
Annals of the New York Academy of Sciences 2007;1110():402-9.
2007: Biegel Annegret; Gebauer Sabine; Hartrodt Bianka; Knütter Ilka; Neubert Klaus; Brandsch Matthias; Thondorf Iris
Recognition of 2-aminothiazole-4-acetic acid derivatives by the peptide transporters PEPT1 and PEPT2.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2007;32(1):69-76.
2007: Thielitz Anja; Reinhold Dirk; Vetter Robert; Bank Ute; Helmuth Martin; Hartig Roland; Wrenger Sabine; Wiswedel Ingrid; Lendeckel Uwe; Kähne Thilo; Neubert Klaus; Faust Jürgen; Zouboulis Christos C; Ansorge Siegfried; Gollnick Harald
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation.
The Journal of investigative dermatology 2007;127(5):1042-51.
2007: Preller Vera; Gerber Annegret; Wrenger Sabine; Togni Mauro; Marguet Didier; Tadje Janine; Lendeckel Uwe; Röcken Christoph; Faust Jürgen; Neubert Klaus; Schraven Burkhart; Martin Roland; Ansorge Siegfried; Brocke Stefan; Reinhold Dirk
TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4632-40.
2006: Reinhold Dirk; Biton Aliza; Pieper Stefanie; Lendeckel Uwe; Faust Jürgen; Neubert Klaus; Bank Ute; Täger Michael; Ansorge Siegfried; Brocke Stefan
Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.
International immunopharmacology 2006;6(13-14):1935-42.
2006: Bank Ute; Heimburg Anke; Helmuth Martin; Stefin Sofia; Lendeckel Uwe; Reinhold Dirk; Faust Jürgen; Fuchs Petra; Sens Bianca; Neubert Klaus; Täger Michael; Ansorge Siegfried
Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)--a novel approach for the treatment of inflammatory bowel disease.
International immunopharmacology 2006;6(13-14):1925-34.
2006: Biegel A; Knütter I; Hartrodt B; Gebauer S; Theis S; Luckner P; Kottra G; Rastetter M; Zebisch K; Thondorf I; Daniel H; Neubert K; Brandsch M
The renal type H+/peptide symporter PEPT2: structure-affinity relationships.
Amino acids 2006;31(2):137-56.
2006: Wrenger Sabine; Faust Jürgen; Friedrich Daniel; Hoffmann Torsten; Hartig Roland; Lendeckel Uwe; Kähne Thilo; Thielitz Anja; Neubert Klaus; Reinhold Dirk
Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function.
Journal of leukocyte biology 2006;80(3):621-9.
2006: Metzner L; Neubert K; Brandsch M
Substrate specificity of the amino acid transporter PAT1.
Amino acids 2006;31(2):111-7.
2006: Biegel Annegret; Gebauer Sabine; Brandsch Matthias; Neubert Klaus; Thondorf Iris
Structural requirements for the substrates of the H+/peptide cotransporter PEPT2 determined by three-dimensional quantitative structure-activity relationship analysis.
Journal of medicinal chemistry 2006;49(14):4286-96.
2006: Thielitz Anja; Reinhold Dirk; Vetter Robert; Lendeckel Uwe; Kähne Thilo; Bank Ute; Helmuth Martin; Neubert Klaus; Faust Jürgen; Hartig Roland; Wrenger Sabine; Zouboulis Christos C; Ansorge Siegfried; Gollnick Harald
Possible role of DP IV inhibitors in acne therapy.
Advances in experimental medicine and biology 2006;575():163-7.
2006: Wrenger Sabine; Guth Bianca; Schultze Bianca; Hoffmann Torsten; Friedrich Daniel; Kähne Thilo; Faust Jürgen; Neubert Klaus; Reinhold Dirk
Expression of dipeptidyl peptidase IV-like enzymes in human peripheral blood mononuclear cells.
Advances in experimental medicine and biology 2006;575():87-91.
2006: Stöckel-Maschek Angela; Stiebitz Beate; Senns Bianca; Lindner Nils; Mögelin Werner; Neubert Klaus
Phosphorus-containing inhibitors of proteolytic enzymes.
Advances in experimental medicine and biology 2006;575():19-26.
2005: Metzner Linda; Kottra Gabor; Neubert Klaus; Daniel Hannelore; Brandsch Matthias
Serotonin, L-tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(11):1468-73.
2005: Kowalczyk Wioleta; Prahl Adam; Dawidowska Olga; Derdowska Izabela; Sobolewski Dariusz; Hartrodt Bianca; Neubert Klaus; Slaninová Jirina; Lammek Bernard
The influence of 1-aminocyclopentane-1-carboxylic acid at position 2 or 3 of AVP and its analogues on their pharmacological properties.
Journal of peptide science : an official publication of the European Peptide Society 2005;11(9):584-8.
2005: Stöckel-Maschek Angela; Stiebitz Beate; Koelsch Regine; Neubert Klaus
Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors.
Bioorganic & medicinal chemistry 2005;13(16):4806-20.
2005: Biegel Annegret; Gebauer Sabine; Hartrodt Bianka; Brandsch Matthias; Neubert Klaus; Thondorf Iris
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.
Journal of medicinal chemistry 2005;48(13):4410-9.
2004: Kowalczyk W; Derdowska I; Dawidowska O; Prahl A; Hartrodt B; Neubert K; Slaninová J; Lammek B
Analogues of arginine vasopressin modified in the N-terminal part of the molecule with enantiomers of N-methylphenylalanine.
The journal of peptide research : official journal of the American Peptide Society 2004;63(5):420-5.
2004: Dawidowska O; Prahl A; Kowalczyk W; Derdowska I; Lammek B; Wierzba T H; Juzwa W; Neubert K; Zabrocki J; Olejniczak B
Potent bradykinin antagonists containing N-benzylglycine or N-benzyl-l-alanine in position 8.
The journal of peptide research : official journal of the American Peptide Society 2004;63(1):29-35.
2004: Knütter Ilka; Hartrodt Bianka; Theis Stephan; Foltz Martin; Rastetter Matthias; Daniel Hannelore; Neubert Klaus; Brandsch Matthias
Analysis of the transport properties of side chain modified dipeptides at the mammalian peptide transporter PEPT1.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;21(1):61-7.
2003: Gebauer Sabine; Knütter Ilka; Hartrodt Bianka; Brandsch Matthias; Neubert Klaus; Thondorf Iris
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.
Journal of medicinal chemistry 2003;46(26):5725-34.
2003: Stöckel-Maschek Angela; Stiebitz Beate; Koelsch Regine; Neubert Klaus
A continuous fluorimetric assay for aminopeptidase P detailed analysis of product inhibition.
Analytical biochemistry 2003;322(1):60-7.
2003: Stirnweiss Jörg; Hartrodt Bianka; Greksch Gisela; Stürzebecher Uta; Böhmer Frank-D; Neubert Klaus; Liebmann Claus
Tyr-c[D-Orn-Tyr(Bzl)-Pro-Gly]: a novel antiproliferative acting somatostatin receptor agonist with mu-opioid receptor-sensitizing properties.
British journal of pharmacology 2003;140(1):13-22.
2003: Lorey Susan; Stöckel-Maschek Angela; Faust Jürgen; Brandt Wolfgang; Stiebitz Beate; Gorrell Mark D; Kähne Thilo; Mrestani-Klaus Carmen; Wrenger Sabine; Reinhold Dirk; Ansorge Siegfried; Neubert Klaus
Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites.
European journal of biochemistry / FEBS 2003;270(10):2147-56.
2003: Bukowska Alicja; Tadje Janine; Arndt Marco; Wolke Carmen; Kähne Thilo; Bartsch Jaqueline; Faust Jürgen; Neubert Klaus; Hashimoto Yuichi; Lendeckel Uwe
Transcriptional regulation of cytosol and membrane alanyl-aminopeptidase in human T cell subsets.
Biological chemistry 2003;384(4):657-65.
2003: Faust Jürgen; Fuchs Petra; Wrenger Sabine; Reinhold Dirk; Stöckel-Maschek Angela; Kähne Thilo; Ansorge Siegfried; Neubert Klaus
Dipeptidyl peptidase IV inhibitors with the N-terminal MXP sequence: structure-activity-relationships.
Advances in experimental medicine and biology 2003;524():175-9.
2003: Lendeckel Uwe; Arndt Marco; Bukowska Alicja; Tadje Janine; Wolke Carmen; Kähne Thilo; Neubert Klaus; Faust Jürgen; Ittenson Annelore; Ansorge Siegfried; Reinhold Dirk
Synergistic action of DPIV and APN in the regulation of T cell function.
Advances in experimental medicine and biology 2003;524():123-31.
2003: Stöckel-Maschek Angela; Stiebitz Beate; Faust Jürgen; Born Ilona; Kähne Thilo; Gorrell Mark D; Neubert Klaus
Different inhibition mechanisms of dipeptidyl peptidase IV by tryptophan containing peptides and amides.
Advances in experimental medicine and biology 2003;524():69-72.
2003: Mrestani-Klaus Carmen; Brandt Wolfgang; Faust Jürgen; Wrenger Sabine; Reinhold Dirk; Ansorge Siegfried; Neubert Klaus
New results on the conformations of potent DP IV (CD26) inhibitors bearing the N-terminal MWP structural motif.
Advances in experimental medicine and biology 2003;524():65-8.
2002: Lorey Susan; Faust Jurgen; Mrestani-Klaus Carmen; Kähne Thilo; Ansorge Siegfried; Neubert Klaus; Bühling Frank
Transcellular proteolysis demonstrated by novel cell surface-associated substrates of dipeptidyl peptidase IV (CD26).
The Journal of biological chemistry 2002;277(36):33170-7.
2002: Reinhold Dirk; Kähne Thilo; Steinbrecher Andreas; Wrenger Sabine; Neubert Klaus; Ansorge Siegfried; Brocke Stefan
The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity.
Biological chemistry 2002;383(7-8):1133-8.
2002: Knütter Ilka; Rubio-Aliaga Isabel; Boll Michael; Hause Gerd; Daniel Hannelore; Neubert Klaus; Brandsch Matthias
H+-peptide cotransport in the human bile duct epithelium cell line SK-ChA-1.
American journal of physiology. Gastrointestinal and liver physiology 2002;283(1):G222-9.
2002: Theis Stephan; Knutter Ilka; Hartrodt Bianka; Brandsch Matthias; Kottra Gabor; Neubert Klaus; Daniel Hannelore
Synthesis and characterization of high affinity inhibitors of the H+/peptide transporter PEPT2.
The Journal of biological chemistry 2002;277(9):7287-92.
2002: Theis Stephan; Hartrodt Bianka; Kottra Gabor; Neubert Klaus; Daniel Hannelore
Defining minimal structural features in substrates of the H(+)/peptide cotransporter PEPT2 using novel amino acid and dipeptide derivatives.
Molecular pharmacology 2002;61(1):214-21.
2001: Knütter I; Theis S; Hartrodt B; Born I; Brandsch M; Daniel H; Neubert K
A novel inhibitor of the mammalian peptide transporter PEPT1.
Biochemistry 2001;40(14):4454-8.
2001: Steinbrecher A; Reinhold D; Quigley L; Gado A; Tresser N; Izikson L; Born I; Faust J; Neubert K; Martin R; Ansorge S; Brocke S
Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):2041-8.
2001: Derdowska I; Prahl A; Neubert K; Hartrodt B; Kania A; Dobrowolski D; Melhem S; Trzeciak H I; Wierzba T; Lammek B
New analogues of bradykinin containing a conformationally restricted dipeptide fragment in their molecules.
The journal of peptide research : official journal of the American Peptide Society 2001;57(1):11-8.
2000: Arndt M; Lendeckel U; Spiess A; Faust J; Neubert K; Reinhold D; Ansorge S
Dipeptidyl peptidase IV (DP IV/CD26) mRNA expression in PWM-stimulated T-cells is suppressed by specific DP IV inhibition, an effect mediated by TGF-beta(1).
Biochemical and biophysical research communications 2000;274(2):410-4.
2000: Wrenger S; Faust J; Mrestani-Klaus C; Fengler A; Stockel-Maschek A; Lorey S; Kahne T; Brandt W; Neubert K; Ansorge S; Reinhold D
Down-regulation of T cell activation following inhibition of dipeptidyl peptidase IV/CD26 by the N-terminal part of the thromboxane A2 receptor.
The Journal of biological chemistry 2000;275(29):22180-6.
2000: Stöckel-Maschek A; Mrestani-Klaus C; Stiebitz B; Demuth H; Neubert K
Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases.
Biochimica et biophysica acta 2000;1479(1-2):15-31.
2000: Vetter R; Reinhold D; Bühling F; Lendeckel U; Born I; Faust J; Neubert K; Ansorge S; Gollnick H
DNA synthesis in cultured human keratinocytes and HaCaT keratinocytes is reduced by specific inhibition of dipeptidyl peptidase IV (CD26) enzymatic activity.
Advances in experimental medicine and biology 2000;477():167-71.
2000: Wrenger S; Reinhold D; Faust J; Mrestani-Klaus C; Brandt W; Fengler A; Neubert K; Ansorge S
Effects of nonapeptides derived from the N-terminal structure of human immunodeficiency virus-1 (HIV-1) Tat on suppression of CD26-dependent T cell growth.
Advances in experimental medicine and biology 2000;477():161-5.
2000: Reinhold D; Hemmer B; Gran B; Steinbrecher A; Brocke S; Kähne T; Wrenger S; Born I; Faust J; Neubert K; Martin R; Ansorge S
Dipeptidyl peptidase IV (CD26): role in T cell activation and autoimmune disease.
Advances in experimental medicine and biology 2000;477():155-60.
2000: Steinbrecher A; Reinhold D; Quigley L; Gado A; Tresser N; Izikson L; Born I; Faust J; Neubert K; Martin R; Ansorge S; Brocke S
Dipeptidyl peptidase IV in inflammatory CNS disease.
Advances in experimental medicine and biology 2000;477():145-53.
2000: Arndt M; Reinhold D; Lendeckel U; Spiess A; Faust J; Neubert K; Ansorge S
Specific inhibitors of dipeptidyl peptidase IV suppress mRNA expression of DP IV/CD26 and cytokines.
Advances in experimental medicine and biology 2000;477():139-43.
2000: Kähne T; Reinhold D; Neubert K; Born I; Faust J; Ansorge S
Signal transduction events induced or affected by inhibition of the catalytic activity of dipeptidyl peptidase IV (DP IV, CD26).
Advances in experimental medicine and biology 2000;477():131-7.
2000: Mrestani-Klaus C; Fengler A; Faust J; Brandt W; Wrenger S; Reinhold D; Ansorge S; Neubert K
N-terminal HIV-1 Tat nonapeptides as inhibitors of dipeptidyl peptidase IV. Conformational characterization.
Advances in experimental medicine and biology 2000;477():125-9.
2000: Stöckel-Maschek A; Stiebitz B; Born I; Faust J; Mögelin W; Neubert K
Potent inhibitors of dipeptidyl peptidase IV and their mechanisms of inhibition.
Advances in experimental medicine and biology 2000;477():117-23.
2000: Lorey S; Faust J; Bühling F; Ansorge S; Neubert K
A new type of fluorogenic substrates for determination of cellular dipeptidyl peptidase IV (DP IV/CD26) activity.
Advances in experimental medicine and biology 2000;477():111-5.
2000: Lendeckel U; Kähne T; Riemann D; Neubert K; Arndt M; Reinhold D
Review: the role of membrane peptidases in immune functions.
Advances in experimental medicine and biology 2000;477():1-24.
1999: Brandsch M; Knütter I; Thunecke F; Hartrodt B; Born I; Börner V; Hirche F; Fischer G; Neubert K
Decisive structural determinants for the interaction of proline derivatives with the intestinal H+/peptide symporter.
European journal of biochemistry / FEBS 1999;266(2):502-8.
1999: Kahne T; Lendeckel U; Wrenger S; Neubert K; Ansorge S; Reinhold D
Dipeptidyl peptidase IV: a cell surface peptidase involved in regulating T cell growth (review).
International journal of molecular medicine 1999;4(1):3-15.
1998: Kähne T; Neubert K; Faust J; Ansorge S
Early phosphorylation events induced by DPIV/CD26-specific inhibitors.
Cellular immunology 1998;189(1):60-6.
1998: Mrestani-Klaus C; Fengler A; Brandt W; Faust J; Wrenger S; Reinhold D; Ansorge S; Neubert K
1H NMR conformational study on N-terminal nonapeptide sequences of HIV-1 Tat protein: a contribution to structure-activity relationships.
Journal of peptide science : an official publication of the European Peptide Society 1998;4(6):400-10.
1998: Börner V; Fei Y J; Hartrodt B; Ganapathy V; Leibach F H; Neubert K; Brandsch M
Transport of amino acid aryl amides by the intestinal H+/peptide cotransport system, PEPT1.
European journal of biochemistry / FEBS 1998;255(3):698-702.
1998: Reinhold D; Hemmer B; Gran B; Born I; Faust J; Neubert K; McFarland H F; Martin R; Ansorge S
Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones.
Journal of neuroimmunology 1998;87(1-2):203-9.
1998: Reinhold D; Vetter R W; Mnich K; Bühling F; Lendeckel U; Born I; Faust J; Neubert K; Gollnick H; Ansorge S
Dipeptidyl peptidase IV (DP IV, CD26) is involved in regulation of DNA synthesis in human keratinocytes.
FEBS letters 1998;428(1-2):100-4.
1998: Brandsch M; Thunecke F; Küllertz G; Schutkowski M; Fischer G; Neubert K
Evidence for the absolute conformational specificity of the intestinal H+/peptide symporter, PEPT1.
The Journal of biological chemistry 1998;273(7):3861-4.
1997: Wrenger S; Hoffmann T; Faust J; Mrestani-Klaus C; Brandt W; Neubert K; Kraft M; Olek S; Frank R; Ansorge S; Reinhold D
The N-terminal structure of HIV-1 Tat is required for suppression of CD26-dependent T cell growth.
The Journal of biological chemistry 1997;272(48):30283-8.
1997: Reinhold D; Bank U; Bühling F; Lendeckel U; Faust J; Neubert K; Ansorge S
Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells.
Immunology 1997;91(3):354-60.
1997: Reinhold D; Bank U; Bühling F; Täger M; Born I; Faust J; Neubert K; Ansorge S
Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-beta 1 (TGF-beta 1) in stimulated mouse splenocytes and thymocytes.
Immunology letters 1997;58(1):29-35.
1997: Schutkowski M; Jakob M; Landgraf G; Born I; Neubert K; Fischer G
Probing substrate backbone function in prolyl oligopeptidase catalysis--large positional effects of peptide bond monothioxylation.
European journal of biochemistry / FEBS 1997;245(2):381-5.
1997: Lorey S; Faust J; Hermanns U; Bühling F; Ansorge S; Neubert K
New fluorogenic dipeptidyl peptidase IV/CD26 substrates and inhibitors.
Advances in experimental medicine and biology 1997;421():157-60.
1997: Reinhold D; Kähne T; Täger M; Lendeckel U; Bühling F; Bank U; Wrenger S; Faust J; Neubert K; Ansorge S
The effect of anti-CD26 antibodies on DNA synthesis and cytokine production (IL-2, IL-10 and IFN-gamma) depends on enzymatic activity of DP IV/CD26.
Advances in experimental medicine and biology 1997;421():149-55.
1997: Bühling F; Reinhold D; Lendeckel U; Faust J; Neubert K; Ansorge S
CD26 is involved in regulation of cytokine production in natural killer cells.
Advances in experimental medicine and biology 1997;421():141-7.
1997: Stöckel A; Stiebitz B; Neubert K
Specific inhibitors of aminopeptidase P. Peptides and pseudopeptides of 2-hydroxy-3-amino acids.
Advances in experimental medicine and biology 1997;421():31-5.
1996: Lendeckel U; Wex T; Reinhold D; Kähne T; Frank K; Faust J; Neubert K; Ansorge S
Induction of the membrane alanyl aminopeptidase gene and surface expression in human T-cells by mitogenic activation.
The Biochemical journal 1996;319 ( Pt 3)():817-21.
1996: Wrenger S; Reinhold D; Hoffmann T; Kraft M; Frank R; Faust J; Neubert K; Ansorge S
The N-terminal X-X-Pro sequence of the HIV-1 Tat protein is important for the inhibition of dipeptidyl peptidase IV (DP IV/CD26) and the suppression of mitogen-induced proliferation of human T cells.
FEBS letters 1996;383(3):145-9.
1996: Mrestani-Klaus C; Brandt W; Schmidt R; Neubert K; Schiller P W
Proton NMR conformational analysis of cyclic beta-casomorphin analogues of the type Tyr-cyclo[N omega-D-Orn-Xaa-Yaa-Gly-].
Archiv der Pharmazie 1996;329(3):133-42.
1996: Reinhold D; Wrenger S; Bank U; Bühling F; Hoffmann T; Neubert K; Kraft M; Frank R; Ansorge S
CD26 mediates the action of HIV-1 Tat protein on DNA synthesis and cytokine production in U937 cells.
Immunobiology 1996;195(1):119-28.
1995: Brandt W; Lehmann T; Thondorf I; Born I; Schutkowski M; Rahfeld J U; Neubert K; Barth A
A model of the active site of dipeptidyl peptidase IV predicted by comparative molecular field analysis and molecular modelling simulations.
International journal of peptide and protein research 1995;46(6):494-507.
1995: Hoffmann T; Reinhold D; Kähne T; Faust J; Neubert K; Frank R; Ansorge S
Inhibition of dipeptidyl peptidase IV (DP IV) by anti-DP IV antibodies and non-substrate X-X-Pro- oligopeptides ascertained by capillary electrophoresis.
Journal of chromatography. A 1995;716(1-2):355-62.
1995: Kähne T; Neubert K; Ansorge S
Enzymatic activity of DPIV/CD26 is involved in PMA-induced hyperphosphorylation of p56lck.
Immunology letters 1995;46(1-2):189-93.
1995: Schutkowski M; Mrestani-Klaus C; Neubert K
Synthesis of dipeptide 4-nitroanilides containing non-proteinogenic amino acids.
International journal of peptide and protein research 1995;45(3):257-65.
1995: Bühling F; Junker U; Reinhold D; Neubert K; Jäger L; Ansorge S
Functional role of CD26 on human B lymphocytes.
Immunology letters 1995;45(1-2):47-51.
1994: Reinhold D; Bank U; Bühling F; Kähne T; Kunt D; Faust J; Neubert K; Ansorge S
Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) specifically suppress proliferation and modulate cytokine production of strongly CD26 expressing U937 cells.
Immunobiology 1994;192(1-2):121-36.
1994: Schmidt R; Vogel D; Mrestani-Klaus C; Brandt W; Neubert K; Chung N N; Lemieux C; Schiller P W
Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects.
Journal of medicinal chemistry 1994;37(8):1136-44.
1994: Schutkowski M; Neubert K; Fischer G
Influence on proline-specific enzymes of a substrate containing the thioxoaminoacyl-prolyl peptide bond.
European journal of biochemistry / FEBS 1994;221(1):455-61.
1994: Friebe S; Hartrodt B; Neubert K; Krauss G J
High-performance liquid chromatographic separation of cis-trans isomers of proline-containing peptides. II. Fractionation in different cyclodextrin systems.
Journal of chromatography. A 1994;661(1-2):7-12.
1993: Hegen M; Mittrücker H W; Hug R; Demuth H U; Neubert K; Barth A; Fleischer B
Enzymatic activity of CD26 (dipeptidylpeptidase IV) is not required for its signalling function in T cells.
Immunobiology 1993;189(5):483-93.
1993: Hoffmann T; Faust J; Neubert K; Ansorge S
Dipeptidyl peptidase IV (CD 26) and aminopeptidase N (CD 13) catalyzed hydrolysis of cytokines and peptides with N-terminal cytokine sequences.
FEBS letters 1993;336(1):61-4.
1993: Reinhold D; Bank U; Bühling F; Neubert K; Mattern T; Ulmer A J; Flad H D; Ansorge S
Dipeptidyl peptidase IV (CD26) on human lymphocytes. Synthetic inhibitors of and antibodies against dipeptidyl peptidase IV suppress the proliferation of pokeweed mitogen-stimulated peripheral blood mononuclear cells, and IL-2 and IL-6 production.
Immunobiology 1993;188(4-5):403-14.
1992: Rüthrich H L; Grecksch G; Schmidt R; Neubert K
Linear and cyclic beta-casomorphin analogues with high analgesic activity.
Peptides 1992;13(3):483-5.
1991: Schmidt R; Neubert K; Barth A; Liebmann C; Schnittler M; Chung N N; Schiller P W
Structure-activity relationships of cyclic beta-casomorphin-5 analogues.
Peptides 1991;12(6):1175-80.
1991: Rahfeld J; Schutkowski M; Faust J; Neubert K; Barth A; Heins J
Extended investigation of the substrate specificity of dipeptidyl peptidase IV from pig kidney.
Biological chemistry Hoppe-Seyler 1991;372(5):313-8.
1991: Schön E; Born I; Demuth H U; Faust J; Neubert K; Steinmetzer T; Barth A; Ansorge S
Dipeptidyl peptidase IV in the immune system. Effects of specific enzyme inhibitors on activity of dipeptidyl peptidase IV and proliferation of human lymphocytes.
Biological chemistry Hoppe-Seyler 1991;372(5):305-11.
1991: Liebmann C; Schnittler M; Hartrodt B; Born I; Neubert K
Structure-activity studies of novel casomorphin analogues: binding profiles towards mu 1-, mu 2- and delta -opioid receptors.
Die Pharmazie 1991;46(5):345-8.
1991: Liebmann C; Mentz P; Schnittler M; Schrader U; Neubert K; Barth A
Nonopioid effects of beta-casomorphin-5 in guinea pig heart: alterations to the beta-adrenoceptor-G-protein complex and inhibition of myocardial responses to isoproterenol.
Peptides 1991;12(2):265-70.
1991: Rahfeld J; Schierhorn M; Hartrodt B; Neubert K; Heins J
Are diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) inhibitors or substrates of dipeptidyl peptidase IV?
Biochimica et biophysica acta 1991;1076(2):314-6.
1990: Schnittler M; Liebmann C; Schrader U; Schulze H P; Neubert K; Repke H
[3H]naloxone as an opioid receptor label: analysis of binding site heterogeneity and use for determination of opioid affinities of casomorphin analogues.
Biomedica biochimica acta 1990;49(4):209-18.
1989: Heiduschka P; Dittrich J; Heins J; Neubert K; Barth A
[Application of dipeptidylpeptidase IV in formation of the peptide bond]
Die Pharmazie 1989;44(11):778-80.
1989: Schön E; Demuth H U; Eichmann E; Horst H J; Körner I J; Kopp J; Mattern T; Neubert K; Noll F; Ulmer A J
Dipeptidyl peptidase IV in human T lymphocytes. Impaired induction of interleukin 2 and gamma interferon due to specific inhibition of dipeptidyl peptidase IV.
Scandinavian journal of immunology 1989;29(2):127-32.
1988: Heins J; Welker P; Schönlein C; Born I; Hartrodt B; Neubert K; Tsuru D; Barth A
Mechanism of proline-specific proteinases: (I) Substrate specificity of dipeptidyl peptidase IV from pig kidney and proline-specific endopeptidase from Flavobacterium meningosepticum.
Biochimica et biophysica acta 1988;954(2):161-9.
1988: Mentz P; Neubert K; Hoffmann S; Liebmann C; Barth A
Effects of beta-casomorphin in isolated heart preparations.
Die Pharmazie 1988;43(4):271-3.
1988: Castiglione-Morelli M A; Hartrodt B; Neubert K; Temussi P A; Trivellone E
Conformational analysis of morphiceptin by NMR spectroscopy.
Biochemical and biophysical research communications 1988;152(2):512-8.
1988: Seliger E; Blumenauer V; Heins J; Neubert K; Kaltwasser P; Schöneich C; Bergleiter R
[Detection of dipeptidyl peptidase IV in follicular fluid--initial report]
Zentralblatt für Gynäkologie 1988;110(20):1312-4.
1987: Schön E; Jahn S; Kiessig S T; Demuth H U; Neubert K; Barth A; Von Baehr R; Ansorge S
The role of dipeptidyl peptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and immunoglobulin synthesis in vitro.
European journal of immunology 1987;17(12):1821-6.
1986: Liebmann C; Barth A; Neubert K; Mentz P; Hoffmann S
Effects of beta-casomorphin on 3H-ouabain binding to guinea pig heart membranes.
Die Pharmazie 1986;41(9):670-1.
1986: Kaemmer D; Neubert K; Demuth H U; Barth A
Contamination of highly purified human serum cholinesterase by dipeptidyl peptidase IV causing hydrolysis of substance P.
Die Pharmazie 1986;41(7):494-6.
1986: Liebmann C; Szücs M; Neubert K; Hartrodt B; Arold H; Barth A
Opiate receptor binding affinities of some D-amino acid substituted beta-casomorphin analogs.
Peptides 1986;7(2):195-9.
1985: Neubert K; Hartrodt B; Mehlis B; Rüger M; Bergmann J; Lindau J; Jakubke H D; Barth A
[Synthesis of cyclic and non-cyclic tachykinin partial sequences. 2. Synthesis of the homocyclic substance P(6-11) hexapeptide]
Die Pharmazie 1985;40(8):532-5.
1985: Neubert K; Bergmann J; Mansfeld J; Hartrodt B; Barth A; Jakubke H D
[Synthesis of cyclic and cyclically branched tachykinin partial sequences. 1. Synthesis of the homodet-cyclic eledoisin(6-11)-hexapeptide]
Die Pharmazie 1985;40(7):456-9.
1984: Weidhase R; Welker P; Dove S; Neubert K; Yoshimoto T; Tsuru D; Barth A
Similarities of the substrate cleavage catalyzed by proline specific endopeptidase and dipeptidyl peptidase IV.
Die Pharmazie 1984;39(12):835-7.
1984: Matthies H; Stark H; Hartrodt B; Ruethrich H L; Spieler H T; Barth A; Neubert K
Derivatives of beta-casomorphins with high analgesic potency.
Peptides 1984;5(3):463-70.
1984: Heins J; Neubert K; Barth A; Canizaro P C; Behal F J
Kinetic investigation of the hydrolysis of aminoacyl p-nitroanilides by dipeptidyl peptidase IV from human and pig kidney.
Biochimica et biophysica acta 1984;785(1-2):30-5.
1983: Ermisch A; Rühle H J; Neubert K; Hartrodt B; Landgraf R
On the blood-brain barrier to peptides: [3H]beta-casomorphin-5 uptake by eighteen brain regions in vivo.
Journal of neurochemistry 1983;41(5):1229-33.
1982: Hartrodt B; Neubert K; Jakubke H D; Baláspiri L; Telegdy G
[Synthesis of cyclo-[des(1,2-L-alanyl-glycine, 14-L-cysteine)-3-s-carboxymethyl-L-homocysteinamid, 8-D-tryptophan]-somatostatin]
Die Pharmazie 1982;37(12):821-4.
1982: Küllertz G; Neubert K; Resch B; Schönberner H
[Comparison of various chromogenic substrates for the determination of L-cystine aminopeptidase (serum oxytocinase, E.C.3.4.1.2)]
Zeitschrift für medizinische Laboratoriumsdiagnostik 1982;23(3):150-5.
1982: Hartrodt B; Neubert K; Jakubke H D; Baláspiri L; Telegdy G
[A new synthesis of somatostatin]
Die Pharmazie 1982;37(6):403-7.
1982: Hartrodt B; Neubert K; Fischer G; Schulz H; Barth A
[Synthesis and enzymatic degradation of beta-casomorphin-5 (author's transl)]
Die Pharmazie 1982;37(3):165-9.
1982: Hartrodt B; Neubert K; Fischer G; Demuth U; Yoshimoto T; Barth A
Degradation of beta-casomorphin-5 by proline-specific-endopeptidase (PSE) and post-proline- cleaving-enzyme (PPCE). Comparative studies of the beta-casomorphin-5 cleavage by dipeptidyl-peptidase IV.
Die Pharmazie 1982;37(1):72-3.
1982: Matthies H; Rüthrich H L; Stark H; Barth A; Neubert K; Hartrodt B
Deproceptin, Tyr-Pro-Phe-D-Pro-NH2, another casomorphin with remarkable analgesic action.
Acta biologica et medica Germanica 1982;41(9):K39-42.

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